Modulation of microbiota function by gene therapy of the microbiome to prevent, treat or cure microbiome-associated diseases or disorders

ABSTRACT

The invention encompasses compositions, kits and methods for modifying bacteria, preferably naturally occurring bacteria, in situ. These can be used to treat, prevent or cure microbiome-associated diseases or disorders by modulating the molecules expressed and/or secreted by bacterial populations of the microbiome in a specific manner. The genomic modifications can modify the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health. The compositions, kits and methods of the invention do not result in the direct death of these populations or a direct significant inhibition of their growth. The invention further includes methods for screening for genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth.

REFERENCE TO SEQUENCE LISTING SUBMITTED ELECTRONICALLY

The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Apr. 8, 2021, is named EB2020-02_USreg_Sequence_listing.txt and is 629,761 bytes in size.

CROSS REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of U.S. application 63/007,191 filed Apr. 8, 2020, U.S. application 63/132,190 filed Dec. 30, 2020, U.S. application 63/137,998 filed Jan. 15, 2021, and U.S. application 63/137,989 of Jan. 15, 2021, all of which are herein incorporated by reference in their entirety.

TECHNICAL FIELD

The present invention relates to compositions, kits and methods for modifying bacteria, preferably naturally occurring bacteria, in situ.

BACKGROUND OF THE INVENTION

The human microbiota comprises bacteria, archaea, viruses, and microbial eukaryotes living in our bodies. The taxonomic composition of these communities has been extensively studied and is significantly associated with a variety of diseases and traits. This microbiota indeed consists of thousands of different bacterial species that carry hundreds of billions of genes, which is called the microbiome. This microbiome encodes for a variety of molecules (proteins, lipids, sugars, RNA, etc.) and functions that are essential and beneficial for their host, for instance the enrichment of glycans metabolism, amino acids and xenobiotics but also the regulation of our immune system. It is also responsible for the synthesis of vitamins, isoprenoids and other nutrients which results in human overall metabolism representing an amalgamation of microbial and human attributes.

Widespread deployment of sequencing technologies has revealed that most bacterial species harbor extensive genetic variation not only between hosts, but often within a host over time, and even within a host at a given time.

Isolation and sequencing of numerous strains highlight the genetic heterogeneity within a single bacterial species. Between different strains within a single bacterial species, this variation comprises single-nucleotide variants, short insertions and deletions (indels), and larger structural variants, which include duplications, deletions, insertions, inversions but also horizontal gene transfer such as prophage or plasmid acquisition and recombination events with such exogenous DNA.

Due to such variations, such strains, when co-existing in a single host, often compete with each other for their existence in a specific microbiome niche.

Interestingly, there is a growing body of recent studies based on metagenome sequencing that demonstrate that the presence of specific strains (and therefore of specific genetic signatures in the microbiome) can be directly linked to a number of pathologies, including autoimmunity, infections, inflammation, neurodegenerative diseases or tumorigenesis.

To treat microbiome-associated diseases or disorders, current approaches try to remove unwanted bacteria (and therefore the deleterious genes they carry) by using subtractive methods such as antibiotics, replicative phages, lysins, which result in the killing of deleterious bacteria but also non-deleterious bacteria.

While such strategies have proven to be beneficial on the short term by significantly reducing the load of entire bacterial populations, it can both:

-   -   induce a strong dysbiosis and indirectly lead to the short-term         overgrowth of non-targeted deleterious bacterial species or         strains. For example, bacteria such as Clostridium difficile are         known to fill the bacterial void created by antibiotic         treatment. Thus, the killing of a particular targeted species or         strain of bacteria within the microbiome can create a void that         can be filled by harmful bacteria both in the short-term and in         the long term. These bacteria can be of the same or a different         species as the targeted species.     -   lead to the emergence of antimicrobial resistance in the long         term and therefore become inefficient in excluding the species         or strain(s) carrying the genetic elements associated with the         pathology. For example, antibiotic use has been associated with         the replacement of antibiotic-sensitive strains of         Staphylococcus aureus with antibiotic-resistant strains of         Staphylococcus aureus. Therefore, The durable elimination of an         engrafted bacterial population in the microbiome can be         challenging to achieve, as the microbiome is naturally in a         state of equilibrium with different populations (strain or         species) occupying different geographic and metabolic niches. A         non-specific treatment like an antibiotic typically leads to a         return to the equilibrium that existed before treatment after a         few weeks or months. On occasion, the equilibrium will be         perturbed for longer periods of time and a dysbiosis can occur.         A targeted elimination of a population by phage therapy         (wild-type phages to engineered phages, packaged phagemids),         lysins, antimicrobial peptides, or any other targeted killing         approaches can be equally challenging as targeted bacterial         survivors will tend to quickly regrow to occupy the niche that         was left empty.

The durable elimination of a bacterial population in the microbiome can be challenging to achieve, as the microbiome is naturally in a state of equilibrium with different populations (strain or species) occupying different geographic and metabolic niches. A non-specific treatment like an antibiotic typically leads to a return to the equilibrium that existed before treatment after a few weeks or months. On occasion, the equilibrium will be perturbed for longer periods of time and a dysbiosis can occur. A targeted elimination of a population by phage therapy (wild-type phages to engineered phages, packaged phagemids), lysins, antimicrobial peptides, or any other targeted killing approaches can be equally challenging as targeted bacterial survivors will tend to quickly regrow to occupy the niche that was left empty.

For these reasons, the genetic modification of a target bacterial population in-situ whether at the strain or species level, can be an interesting alternative. It can lead to the modification of a deleterious population to remove its deleterious effect without killing the target bacteria, and in some cases even without affecting its fitness therefore not disturbing the equilibrium of the ecosystem.

In this way, no void would be created that could be filled by harmful bacteria nor would it lead to treatment resistance. Such an approach would represent a very powerful and elegant approach to treat, prevent or cure a number of microbiome-associated diseases or disorders, especially in the case of long term or chronic pathologies. The invention fulfills this need.

BRIEF SUMMARY OF INVENTION

The invention relates to methods, kits and compositions for modifying a naturally occurring bacteria in situ. In one embodiment, the method, in particular the non-therapeutic method, comprises genetically modifying a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. Preferably, the genetic modification does not lead to the death of bacteria.

In one embodiment, the method, in particular the non-therapeutic method, comprises contacting said naturally occurring bacteria with a vector encoding enzymes or systems for inducing genetic modifications. The invention also concerns a vector encoding enzymes or systems for inducing genetic modifications, for use in a therapeutic method of modifying a naturally occurring bacteria in situ and/or in vivo.

In one embodiment, said vector further comprises a conditional origin of replication which is inactive in the targeted bacteria but is active in a donor bacterial cell. In a particular embodiment, said conditional origin of replication is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs). In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase. In a particular embodiment, said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073. In a particular embodiment, said conditional origin of replication comprises or consists of the sequence SEQ ID NO: 7 or SEQ ID NO: 8.

In one embodiment, said vector is devoid of an antibiotic resistance marker.

In one embodiment, said vector is located inside a delivery vehicle that allows the transfer of the vector into bacteria, more particularly inside a bacterial virus particle. In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector located inside a delivery vehicle that allows the transfer of the vector into bacteria. Preferably, the vector located inside a delivery vehicle is a phagemid and, preferably, the delivery vehicle is a bacterial virus particle or a capsid.

In a particular embodiment, said vector is inside a bacterial virus particle, more particularly is in the form of a packaged phagemid. In one embodiment, the method comprises transducing said naturally occurring bacteria with a packaged phagemid. Preferably, the phagemid comprises a nucleic acid sequence encoding a modified nuclease that is modified to be unable to perform DNA double strand break while retaining its DNA binding capacity and that is fused to a domain to perform other types of function, such as for instance a domain to perform base editing. Preferably, the phagemid comprises a nucleic acid sequence encoding a nuclease that is an RNA guided nuclease. Preferably, the phagemid comprises a nucleic acid sequence encoding a dCas9 (dead-Cas9) or nCas9 (nickase Cas9). In one embodiment, the phagemid comprises a nucleic acid sequence encoding a dCas9 and a deaminase domain, or a nCas9 and a deaminase domain.

In one embodiment, the genetic modification is at least one point mutation(s).

In one embodiment, the genetic modification is at least one insertion or at least one deletion.

In one embodiment, the genetic modification is at least one point mutation(s), insertion and/or deletion inside a coding sequence leading to a frameshift mutation.

In one embodiment, the bacteria with the genetic modification does not have a reduced in vivo growth rate and/or fitness as compared to the same bacteria without the genetic modification.

In one embodiment, the genetic modification is in a bacterial toxin gene. In one embodiment, the genetic modification is in the ClbP gene in pks+ E. coli and results in a single amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. Preferably, the genetic modification is at S95 or K98 of the ClbP gene. More preferably, the genetic modification is selected from the group consisting of S95A, S95R and K98T¹.

In one embodiment, the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene, said beta-galactosidase gene being typically of sequence SEQ ID NO: 2323, and typically encoding a protein of sequence SEQ ID NO: 2322. Preferably, the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide, said human MYH6 cardiac peptide being typically of sequence SEQ ID NO: 2324, as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification².

In one embodiment, the method comprises genetically modifying at least one DNA sequence or gene in the naturally occurring bacteria in situ in a subject, in particular in a human. In one embodiment, the method comprises modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ wherein said naturally occurring bacteria is involved in microbiome associated disorder or disease.

In one embodiment, the method comprises genetically modifying a DNA sequence responsible for a microbiome associated disorder or disease in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. In one embodiment, the genetic modification reduces the effects of the microbiome associated disorder or disease, and the genetic modification does not lead to the death of bacteria. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In one embodiment, the method is to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the host microbiome. In one embodiment, the method comprises contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population without cleaving the DNA sequence. The invention also concerns a vector generating a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by bacteria in at least some of the bacteria of a bacterial population of a host microbiome without cleaving the DNA sequence, for use to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host, wherein said vector modifies the immunogenic profile of said bacterial population. Preferably, the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, wherein said genetic modification does not lead to the direct death of the bacteria. Preferably, the genetic modification of the DNA sequence coding for the immunogenic component results in the inability of the immune system to recognize the immunogenic component. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector encoding enzymes or systems for inducing genetic modifications.

In one embodiment, said vector further comprises a conditional origin of replication which is inactive in the targeted bacteria but is active in a donor bacterial cell. In a particular embodiment, said conditional origin of replication is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, nucleic acid, RNA, molecule or any combination thereof. In a particular embodiment, said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs). In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase. In a particular embodiment, said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073. In a particular embodiment, said conditional origin of replication comprises or consists of the sequence SEQ ID NO: 7 or SEQ ID NO: 8.

In one embodiment, said vector is devoid of an antibiotic resistance marker.

In one other embodiment, said vector comprises an auxotrophic marker.

In one embodiment, said vector is located inside a delivery vehicle that allows the transfer of the vector into bacteria, more particularly inside a bacterial virus particle.

In one embodiment, the method comprises contacting said naturally occurring bacteria with a vector located inside a delivery vehicle that allows the transfer of the vector into bacteria.

Preferably, the delivery vehicle with the vector is a packaged phagemid.

In a particular embodiment, said packaged phagemid comprises a phagemid encoding an enzyme that modifies the genome of said bacterial. Preferably, said enzyme is a base editor or a prime editor.

In one embodiment, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that modifies the genome of said bacteria. Preferably, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that is a base editor. Preferably, the method comprises transducing said bacteria with a packaged phagemid comprising a phagemid encoding an enzyme that is a prime editor.

In one embodiment, the modification is at least one point mutation(s) in a protein-encoding nucleic acid sequence that results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic i.e. not recognized by the immune system.

In one other embodiment, the genetic modification results in a change of sugar profile on the bacterial membrane.

In one other embodiment, the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of sugar profile on the bacterial membrane

In one other embodiment, the genetic modification results in a change of lipid profile on the bacterial membrane.

In one other embodiment, the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of lipid profile on the bacterial membrane.

In one embodiment, the genetic modification renders a catalytic site inactive. In one embodiment, the genetic modification renders a binding site with a human cell receptor non-functional.

In one embodiment, the genetic modification is a point mutation(s) that results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic i.e. not recognized by the immune system.

In one embodiment, the genetic modification(s) that result(s) in a change of amino acid on the protein sequence are/is chosen so that a single genetic mutation cannot revert the modified amino acid back to original.

The invention encompasses methods for screening for genetic modifications in bacteria. In one embodiment, the method comprises:

-   -   administering, to a subject, a vector designed to genetically         modify at least one base of a DNA sequence of interest in a gene         or DNA sequence of a naturally occurring bacteria without         introducing a double strand break in said DNA sequence,     -   subsequently collecting a bacterial sample from the subject, and     -   quantitating the level of bacteria containing a genetic         modification in said at least one base of a DNA sequence of         interest in said bacterial sample.

In one embodiment, the method comprises quantitating the level of bacteria not containing a genetic modification in at least one base of a DNA sequence of interest.

The invention encompasses methods for determining the efficiency of a vector at inducing genetic mutations in situ comprising:

-   -   administering, to a subject, a vector designed to genetically         modify at least one base of a DNA sequence of interest in a gene         or DNA sequence of a naturally occurring bacteria without         introducing a double strand break in said DNA sequence,     -   subsequently collecting a bacterial sample from the subject,     -   quantitating the level of bacteria containing a genetic         modification in said at least one base of a DNA sequence of         interest and quantitating the level of bacteria not containing a         genetic modification in said at least one base of a DNA sequence         of interest in said bacterial sample.

The invention also encompasses a method for modifying a naturally occurring bacteria in situ in a subject, said method comprising:

-   -   collecting a bacterial sample from the microbiome of the         subject,     -   contacting said bacterial sample with a vector designed to         genetically modify at least one base of a DNA sequence of         interest in a gene or DNA sequence of a naturally occurring         bacteria without introducing a double strand break in said DNA         sequence,     -   quantitating the level of bacteria containing a genetic         modification in said at least one base of a DNA sequence of         interest and quantitating the level of bacteria not containing a         genetic modification in said at least one base of a DNA sequence         of interest in said bacterial sample, and determining thereby         the efficiency of said vector at inducing genetic mutations in         said subject, and     -   administering, to said subject, said vector designed to         genetically modify at least one base of a DNA sequence of         interest in a gene or DNA sequence of a naturally occurring         bacteria without introducing a double strand break in said DNA         sequence, in particular when said determined efficiency is         higher than or equal to a given value.

The invention encompasses methods for determining the effect of a genetic mutation on bacterial growth comprising:

-   -   administering, to a subject, a vector designed to genetically         modify at least one base of a DNA sequence of interest in a gene         or DNA sequence of a naturally occurring bacteria, without         introducing a double strand break in said DNA sequence,     -   subsequently collecting at least two sequential bacterial         samples from the subject,     -   quantitating the level of bacteria containing a genetic         modification in said at least one base of a DNA sequence of         interest and quantitating the level of bacteria not containing a         genetic modification in said at least one base of a DNA sequence         of interest in said bacterial samples.

In one embodiment, said genetic modification is a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin but maintains the antagonistic activity.

The invention encompasses a bacteriophage, bacterial virus particle or packaged phagemid for modifying in situ a naturally occurring bacteria, said bacteriophage, bacterial virus particle or packaged phagemid comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the genome of said target bacteria without introducing a double strand break in the DNA sequence, but does not lead to the death of the target bacteria. The invention encompasses the use of said bacteriophage, bacterial virus particle or packaged phagemid, wherein the gene editing enzyme/system targets a DNA sequence or gene within the target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder. The invention encompasses a bacteriophage, bacterial virus particle or packaged phagemid comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the DNA sequence or gene within said target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder without introducing a double strand break in the DNA sequence, for use for preventing and/or treating said disease or disorder.

Furthermore, a subject's microbiome can affect the metabolism of drug, food supplement, prebiotic or even cosmetic agent, or any compound administered or produced by the host or produced by other bacteria from the host, or affect the interaction of such compounds with the host or action of such compounds on the host. The invention thus also concerns a method to modify in situ interaction of a bacteria from a microbiome of a subject with a compound administered to or produced by said subject or produced by other bacteria from said subject, by modifying at least one bacterial DNA sequence involved in the interaction of said bacteria with said compound, said bacterial DNA sequence being expressed by a bacterial population of the host microbiome, said method comprising:

contacting the bacterial population with a vector that generates a genetic modification in said at least one DNA sequence of the bacteria, involved in the interaction of said bacteria with said compound, in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence;

wherein the genetic modification of said at least one DNA sequence results in a modification of the interaction of the bacteria with said compound; and

wherein the genetic modification does not lead to the direct death of the bacteria.

Said interaction of a bacteria with a compound administered to or produced by the subject or produced by other bacteria from said subject, encompasses (i) modification of said compound by said bacteria and/or (ii) competition between said compound and a molecule produced and/or secreted by said bacteria for a ligand from said subject and/or (iii) binding/adsorption of said compound by said bacteria.

In a particular embodiment, the invention concerns a method to modify the metabolism of a given drug in a host treated with said drug, by modifying at least one drug-targeting enzyme expressed by a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the DNA sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

Said modification of the metabolism of a given drug may be selected from the group consisting of a modification preventing-transformation of a given drug into a toxic compound for the host, a modification preventing hydrolysis of a given drug thus leading to a prolonged activity of said drug, an enzymatic modification of a given drug leading to an increased and/or prolonged activity of said drug, a transformation of said given drug into an active or more active compound, a modification preventing reactivation of detoxified compounds from a given drug.

The invention encompasses compositions and methods to ensure a robust alteration of all targeted bacteria within a microbiome population, thanks to the delivery of a nuclease programmed to discriminate between target bacteria that have been genetically modified in situ and target bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. The present invention thus further concerns a method for ensuring a robust alteration of all targeted bacterial within a microbiome population, said method comprising contacting said microbiome population with a vector comprising a nucleic acid encoding a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and target bacteria in which the modification has not occurred, wherein said programmed nuclease enables the specific killing of targeted bacteria in which the modification has not occurred. In a particular embodiment, the delivery of such nuclease is either on the same DNA payload as the one containing the base-editing nuclease, or on a different payload. In other words, in a particular embodiment, the nucleic acid encoding said programmed nuclease is located on the same vector as the one comprising the nucleic acid encoding the base-editing nuclease or on a different vector. In a particular embodiment, the delivery of such nuclease is either simultaneous with or after the delivery of the payload containing the base-editing. In other words, in a particular embodiment, said vector comprising a nucleic acid encoding said programmed nuclease is administered either simultaneously or after the vector comprising the nucleic acid encoding the base-editing nuclease. If delivered simultaneously, the payload can be engineered to have a delayed targeting process for the programmed nuclease leading to DNA double strand break.

BRIEF DESCRIPTION OF DRAWINGS

In order to better understand the subject matter that is disclosed herein and to exemplify how it may be carried out in practice, embodiments will be described, by way of non-limiting example, with reference to the accompanying drawings. With specific reference to the drawings, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of embodiments of the invention.

FIG. 1 depicts a method for modifying a naturally occurring bacteria in situ. Bacteria in absence of treatment produce molecules leading to pathogenicity such as inflammation. Upon treatment in the case of non-efficient target cell modification, only a fraction of the bacterial population is genetically modified to express a modified molecule that is non-pathogenic whereas non genetically modified bacteria are still producing the pathogenic variant. This heterogenous bacterial population and their associated molecules lead to mild disease state compared to the no treatment case. Finally, in case of an efficient target cell modification of all the population or a vast majority, the pathogenic variant of the molecule is not present anymore or in quantity low enough to have no pathogenicity and reach a healthy state.

FIG. 2 depicts a method for modification of bacterial antigens in a naturally occurring bacteria in situ where the bacterial antigen mimics a human protein. The bacterial antigen is presented by an antigen presenting cell (APC) to a T cell leading to its activation and an immune response targeted towards on one side the bacterial antigen and on the other side the human protein or self-antigen thus leading to auto-immune reaction.

FIG. 3 depicts a screening method for the modification of a naturally occurring bacteria in situ. Before treatment the patient is optionally getting sampled to detect and quantify potential bacterial targets. Then the treatment is administered on different forms (oral, systemic, topical) depending on the target microbiome localization. After treatment the patient is getting sampled to detect and/or quantify bacterial targets and the genetic modifications induced by the treatment.

FIGS. 4A-B presents graphs showing base editing of mCherry on the E. coli genome after transformation in vitro. FIG. 4A) Adenine base editing (ABE=ABE8e) of mCherry. The experiment was performed in the presence (48 colonies analysed) or absence (2 colonies analysed) of a guideRNA targeting the active site of mCherry (tripeptide: M71, Y72, G73). FIG. 4B) Cytosine base editing (CBE=evoAPOBEC1-nCas9-UGI) of mCherry. The experiment was performed in the presence (48 colonies analysed) or absence (2 colonies analysed) of a guideRNA inserting a stop codon into mCherry. Fluorescence was measured by flow cytometry (arbitrary units a.u.) of individual colonies (1 dot represents a single colony after overnight incubation on agar plates).

FIGS. 5A-C presents histograms and graphs showing base editing of β-lactamase on the E. coli genome after phagemid transduction in vitro. FIG. 5A) Titers of lambda packaged phagemids comprising a base editor payload (ABE=ABE8e, CBE=evoAPOBEC1-nCas9-UGI). FIG. 5B) Multiplicity of infection (MOI)-dependent adenine base editing (ABE) targeting the active site of β-lactamase gene (K71E) on the genome. FIG. 5C) Multiplicity of infection (MOI)-dependent cytosine base editing (CBE) of β-lactamase. Editing of the active site of β-lactamase diminishes cell growth on carbenicillin plates.

FIG. 6 presents histograms showing adenine base editing of β-lactamase after transduction into E. coli in oligoMM mice in vivo. The packaged phagemids titer for the in vivo experiment was 1.5×10⁹ transduction units (tu)/μl. Stool samples were analysed 0, 6, and 48 hours post transduction (48, 96, 88 colonies, respectively). Cells were plated on streptomycin, chloramphenicol, and carbenicillin plates in order to analyse delivery and editing efficiency. Editing of the active site of β-lactamase (K71) results in a loss of cell growth on carbenicillin plates.

FIGS. 7 and 8 depict the plasmid maps of the constructed base editors. Adenine base editing was exemplarily performed by ABE8e (FIG. 7; SEQ ID NO: 2). ABE8e comprises an evolved TadA* gene fused to a nCas9 (D10A). Cytosine base editing was exemplarily performed by evoAPOBEC1-nCas9-UGI (FIG. 8; SEQ ID NO: 4). The UGI fused to the nCas9 (D10A) prevents the repair of U:G mismatches back into C:G base pairs. The DNA payloads carry a cos site for packaging into lambda phagemid particles.

FIG. 9 displays histograms showing prime editing of Red Fluorescent Protein (RFP) on the E. coli genome in vitro. The genomic RFP gene was amplified from 18 individual colonies and the resulting PCR fragments were sequenced. The editing efficiency was calculated from these data.

FIG. 10 displays a graph showing adenine base editing of β-lactamase on the E. coli genome after packaged phagemid transduction in vitro using a non-replicative payload based on a primase-helicase. An MG1655 strain encoding the β-lactamase gene was transduced in the presence or absence of the primase-helicase protein expressed inside the cell. Transduced cells were plated on LB and LB (carbenicillin) plates 2 hours post transduction at different multiplicity of infections (MOI). The next day, base editing efficiency was analyzed via colony counting.

FIG. 11 displays a picture showing transformation of a 2.3 kb payload containing the primase-origin of replication in a production strain harboring an inducible primase RBS library in trans.

FIG. 12 displays histograms comparing packaged phagemids titers obtained with a plasmid containing the primase-ori in production strains tested against 7 different primase RBS. Right column, in black, control plasmid with a p15a-derived origin of replication. Titers shown are after a 10× concentration.

FIG. 13 displays a picture comparing cells transduced with a primase-ori plasmid (top row) and a p15a-based packaged phagemids on LB agar plus 25 μg/mL chloramphenicol.

FIG. 14 displays histograms showing adenine base editing of β-lactamase after packaged phagemid transduction into E. coli in ten oligoMM mice using a non-replicative payload based on a primase-helicase. Delivery and editing efficiency of adenine base editing in vivo. The packaged phagemid titer for the in vivo experiment was 1.5*10¹⁰ tu/μl. Stool samples were analysed 24h post transduction. Cells were plated on streptomycin and streptomycin/carbenicillin in order to analyse editing efficiency (20 colonies per mouse). Editing of the active site of β-lactamase (K71) resulted in a loss of cell growth on carbenicillin plates. After 24 hours, base editing efficacy was ˜75% of the whole population on average.

TABLES

Table 1 presents gut bacterial species carrying candidate mimic peptide, amino acids sequence of related mimic peptide and Uniprot ID of bacterial and human protein containing each mimic peptide.

Table 2 presents nucleic acid sequences encoding drug-metabolizing gene products (identified by start nucleotide and end nucleotide in the listed contigs).

DETAILED DESCRIPTION OF INVENTION

The invention encompasses compositions, kits and methods, in particular non-therapeutic methods, for modifying a naturally occurring bacteria in situ. The invention further encompasses compositions, kits and methods, in particular non-therapeutic methods, for modifying a non-naturally occurring bacteria, such as one with an ex vivo genetic modification, in situ. The compositions, kits and methods of the invention genetically modify deleterious bacterial strains within the host microbiome to turn them into non-deleterious strains for the host without directly killing these strains.

The invention further encompasses modifications that improve or functionalize non deleterious bacteria. The invention further includes methods for screening for genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth or on any bacterial function, for increasing the ratio of modified bacteria vs non-modified bacteria in situ, for increasing the chance that this approach leads to a positive outcome in a patient.

Preferably, the genetic modifications are modifications of a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence. Thus, the method includes generating no cleavages in the DNA sequence, generating a nick in one strand of the DNA sequence, or generating a staggered nicks in both strands of the DNA sequence, that do not lead to a double strand break in the DNA sequence.

Provided herein are compositions, kits and methods of treating, preventing or curing microbiome-associated diseases or disorders by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function. The invention also concerns a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ for use for treating, preventing or curing a microbiome-associated disease or disorder by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in particular in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function. The invention also concerns the use of a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ in the manufacture of a medicament intended to treat, prevent or cure a microbiome-associated disease or disorder by modulating either the molecules expressed and/or secreted by bacterial populations of the microbiome or their expression/secretion levels, in particular in a specific manner that will result in the modification of the interactions between part or all of these populations and the host in a way that decreases their deleterious potential on host health, and which will not result in the direct death of these populations, a direct significant inhibition of their growth or impairment of major bacterial function.

The invention encompasses the use of a vector that can transduce with high efficiency a nucleic acid, preferably a plasmid or a phagemid, into a bacterial population within the microbiome that allows the expression of an exogenous enzyme that will modify a DNA or gene sequence. The bacterial population can be a mixed bacterial population, comprising different strains of the same species; alternatively, the bacterial population can be a mixed bacterial population, comprising different strains of different species. In some embodiments, the DNA sequence or gene has a direct or indirect effect on the interactions of the bacteria with the host. Thus, the invention encompasses vectors for use in transducing with high efficiency a nucleic acid, preferably a plasmid or a phagemid, into a bacterial population.

In some embodiments, the DNA sequence or gene having a direct effect includes a DNA sequence or gene expressing a toxin that interacts with host cells, or a bacterial protein or peptide that includes a sequence of amino acids that mimic a sequence of amino acids present in the host proteins or peptides.

In some embodiments, the DNA sequence or gene having an indirect effect includes DNA sequences or genes that encode for an enzyme expressed, displayed on the membrane or secreted by the bacteria that is involved in the internal production or modification of a sugar, lipid, metabolite or protein that is present inside the bacteria, expressed or displayed on the membrane of the bacteria, secreted by the bacteria or imported by the bacteria.

Preferably, the precise modification of the DNA sequence or gene sequence is performed so that it minimizes any effect on the ability of the bacteria to grow and interact with other microorganisms in its biological environment, but modifies its interaction with the host or its growth or resistance potential during a treatment.

Methods of Genetic Modification

The invention encompasses methods of modifying a naturally occurring bacteria in situ. Preferably, the genetic modification does not lead to the death of bacteria. More preferably, the genetic modification results in less than a 5%, 10%, 20%, or 50% growth disadvantage of the modified bacteria in vivo due to the genetic modification. Even more preferably, the genetic modification does not result in any growth disadvantage of the modified bacteria in vivo due to the modification. Preferably, the genetic modification is a modification of a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence,

In a preferred embodiment, the bacteria are contacted in situ with a vector that can transfer with high efficiency a nucleic acid into the bacteria to express an exogenous enzyme in the bacteria that results in a genetic modification. In a preferred embodiment, the exogenous enzyme can result in this genetic modification through base editing strategies where dCas9 (dead-Cas9) or nCas9 (nickase Cas9) is fused to cytosine or adenosine deaminase domain and directed to the target sequence to make the desired modification.

In a preferred embodiment, the exogenous enzyme can result in this genetic modification through prime editing strategies where dCas9 (dead-Cas9) or nCas9 (nickase Cas9) is fused to reverse transcriptase domain and directed to the target sequence to make the desired modification with the help of a pegRNA (prime editing guide RNA).

Nevertheless, the invention also contemplates introducing a double strand break or a single strand break i.e. a nick in the bacterial DNA at a specific sequence, for example with a CRISPR/Cas system, together with non-homologous end joining (NHEJ) or homologous recombination (HR) to generate the desired genetic modification. Preferably, the double strand break or the single strand break is generated in the presence of an editing template comprising homologous regions with DNA regions located around the specific sequence located in the bacterial DNA.

The genetic modification can be a point mutation(s), a deletion(s), insertion(s) or any combination thereof.

In some embodiments, the genetic modification can inactivate, reduce, increase or induce the expression of a DNA sequence or gene. The genetic modification can be in the translated or untranslated regions of a gene. The genetic modification can be in the promoter region of a gene or within any other region involved in gene regulation.

In some embodiments, the DNA sequence or gene inactivation can be a point mutation(s) inside the coding sequence (starts with start codon, ends with stop codon). More precisely, the DNA sequence or gene inactivation can be performed by a point mutation(s) converting one or several codons to stop codon (TAA, TAG, TGA). Alternatively, the DNA sequence or gene inactivation can be performed by a point mutation(s) converting the start codon (ATG, GTG, TTG) or any in-frame start codon in 5, 10, 20, 50, 100 bp of the predicted start codon into a non-start codon or a stop codon. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing rare codons inside the codon sequence. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing non-synonymous amino acid change(s) in a catalytic site making the protein inactive for the function associated to this catalytic site. Alternatively, the DNA sequence or gene inactivation can be performed by point mutation(s) introducing non-synonymous amino acid change(s) in a site involving binding other molecules where the interaction is necessary for the protein activity.

In some embodiments, the DNA sequence or gene inactivation can be a point mutation(s) outside the coding sequence. Point mutation(s) can be in the promoter region of a gene (e.g. −35 bp region, −10 bp region, transcription start site (TSS)), in the Ribosome Binding Site (RBS) of the gene or within any other region involved in regulation (e.g. transcription factor binding site, operator binding site, riboswitch . . . ).

In some embodiments, the genetic modification can lead to DNA sequence or gene activation.

In some embodiments, the genetic modification can be a point mutation(s) that revert a previously characterized mutation that inactivate, decrease or increase the activity of a gene or pathway.

In some embodiments, the genetic modification can be a point mutation(s) leading to modulation of DNA sequence or gene expression and regulation. Point mutation(s) can be in promoter region of a gene (e.g. −35 bp region, −10 bp region, transcription start site (TSS)), in the Ribosome Binding Site (RBS) of the gene, within any other region involved in regulation (e.g., transcription factor binding site, operator binding site, RNAse recognition site, riboswitch, methylation sit, etc.) or in any other DNA sequence or gene regulating the DNA sequence or gene of interest such as a repressor, an antisense RNA, an activator.

In some embodiments, the genetic modification can be point mutation(s) leading to modulation of post translational modification(s) (e.g., phosphorylation, glycosylation, acetylation, pupylation, etc.). More particularly the modification can be a point mutation in the post translational modification site. Alternatively, the genetic modification can disrupt the DNA sequence or gene responsible for post-translational modification(s).

In another embodiment, the genetic modification is a point mutation(s) that revert a mutation that leads to an increase of pathogenicity.

In a particular embodiment, the genetic modification does not integrate a phage genome or exogenous DNA into the host bacterial chromosome or endogenous plasmid(s). In a particular embodiment, the genetic modification does not result in expression of an exogenous protein from an integrated exogenous DNA in the host bacterial chromosome or endogenous plasmid(s). In a more particular embodiment, the genetic modification does not involve either NHEJ or HR endogenous repair mechanism of the host bacteria.

In some embodiments, the genetic modification results in the change in at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 35, 40, 45, 50, 100, 200, 500, etc. amino acids to a different amino acid.

The invention encompasses methods, in particular non-therapeutic methods, of modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ. Preferably, the naturally occurring bacteria is involved in microbiome associated disorder or disease. In preferred embodiments, the method comprises genetically modifying a DNA sequence responsible for the microbiome associated disorder or disease in the naturally occurring bacteria in situ, wherein the genetic modification reduces the effects of the microbiome associated disorder or disease, and wherein the genetic modification does not lead to the death of bacteria. The invention further encompasses a vector encoding enzymes or systems for inducing genetic modifications in naturally occurring bacteria in situ for use in a method for reducing the effects of a microbiome associated disorder or disease, wherein said vector genetically modifies a DNA sequence, in the naturally occurring bacterial in situ, responsible for said microbiome associated disorder or disease, and wherein the genetic modification does not lead to the death of bacteria. Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In some embodiments, the genetic modification occurs within a pathogenic bacterial DNA sequence or gene encoding a virulence factor to block pathogenesis, which de-facto might reduce the fitness of the bacteria, since virulence factor often confer a fitness advantage of the pathogenic bacteria over its bacterial competitors. This might for example lead to a lower growth-rate.

In other embodiments, the genetic modification occurs within commensal bacteria or opportunistic pathogens, and the modification has a small or no impact on the growth rate of this bacteria as a commensal bacteria.

The invention encompasses methods to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the human or animal microbiome. In preferred embodiments, the method comprises contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population, wherein the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, and wherein the genetic modification does not lead to the direct death of the bacteria. The invention further encompasses a vector encoding enzymes or systems for inducing genetic modifications for use in a method to prevent or intervene in the course of an auto-immune disease or reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the human or animal microbiome. In preferred embodiments, said vector generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population, wherein the genetic modification of the DNA sequence coding for the immunogenic component results in loss of the immunogenic effect of said immunogenic component, and wherein the genetic modification does not lead to the direct death of the bacteria.

Preferably, the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

In some embodiments, the genetic modification results in a change of amino acid in a mimic peptide and renders the mimic peptide not immunogenic or not recognized by the immune system. In some embodiments, the genetic modification results in a change of sugar profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of amino acid in a protein sequence that results in a change of sugar profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of lipid profile on the bacterial membrane. In some embodiments, the genetic modification results in a change of amino acid in a protein sequence that results in a change of lipid profile on the bacterial membrane. In some embodiments, the genetic modification results in a change at the protein sequence level leading to an inactive catalytic site. In some embodiments, the genetic modification renders a binding site with a human cell receptor non-functional. In some embodiments, the genetic modification renders the bacteria more sensitive to detection by human immune cells.

Modification of a Bacterial Toxin Gene Sequence

In some embodiment, the genetic modification is made in a toxin gene sequence so that the toxin is still produced, expressed and or secreted but renders its toxigenic effect null, resulting in the modification of one or multiple amino acids of the catalytic site of the enzyme so that it cannot exert its toxigenic effect on the host cells.

Alternatively, the genetic modification is made in a toxin gene sequence so that the toxin gene sequence is not expressed or disrupted, resulting in the inactivation of the toxin.

The targeted bacterial toxin can be an exotoxin or endotoxin. Exotoxins are generated and actively secreted; endotoxins remain part of the bacteria. The response to a bacterial toxin can involve severe inflammation and can lead to sepsis.

Preferred toxins include Colibactin of E. coli, Toxin A and other enzymes (e.g., hemolysin, leukotoxin, exfoliative toxin, enterotoxin, and toxic-shock syndrome toxin-1 (TSST-1)) from Staphylococcus aureus as described in Tam and Torres, Microbiol Spectr. 2019 March; 7(2), which is hereby incorporated by reference, and fragilysin (Bft) from Enterotoxigenic (ETBF) strains of Bacteroides fragilis, Botulinum neurotoxin, Tetanus toxin, Diphteria toxin, Anthrax toxin, Alpha toxin, Pertussis toxin, Shiga toxin, Heat-stable enterotoxin (E. coli ST), or any toxin described in Henkel et al., (Toxins from Bacteria in EXS. 2010; 100: 1-29, which is hereby incorporated by reference).

By “colibactin” is meant herein a secondary metabolite synthetized by the clbA-S genes present in the 54-kb pathogenicity pks island, a genetic island encoding a non-ribosomal peptide synthetase-polyketide synthase (NRPS-PKS) assembly line in Enterobacteriaceae. Colibactin is typically produced as a prodrug moiety that is exported in the periplasm by the efflux pump ClbM and then hydrolyzed by the periplasmic membrane-bound ClbP protein with a peptidase activity, which releases the active colibactin.

In preferred embodiments, the genetic modification is a point mutation(s) leading to toxin gene disruption such as described previously.

Preferably, the bacteria with the genetic modification do not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

Preferably, the genetic modification(s) are done so that a single genetic mutation cannot revert the activity of the toxin. This can be achieved by changing the original amino acid for another amino acid that cannot be reverted to original by a single substitution.

In one embodiment, the method comprises making a genetic modification in the ClbP gene in pks+ E. coli that result in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. In a particular embodiment, the genetic modification is in the ClbP gene in pks+ E. coli and results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, while maintaining its antagonistic activity.

As used herein, the ClbP gene is typically of sequence SEQ ID NO: 2316 and typically encodes a protein of sequence SEQ ID NO: 2317.

Preferably, the genetic modification is at codons of the ClbP gene encoding amino acids S95 or K98 of the protein encoded by the ClbP gene, in particular at codons of the ClbP gene encoding amino acids S95 or K98 of SEQ ID NO: 2317. Most preferably, the genetic modification is a mutation S95A, S95R or K98T in the ClbP gene.

In some embodiments, the genetic modification is made in a Shigella toxin gene such as, without limitation, stx1 and stx2. In some embodiments, the genetic modification is made in a E. coli toxin gene such as, without limitation, Stx1 (VT1), Stx2 (VT2), Stx2a (VT2a), Stx2b (VT2b), Stx2c (VT2c), Stx2d (VT2d), Stx2e (VT2e) and Stx2f (VT2f), Stx2h (VT2h), stx2k.

Modification of Other Bacterial Virulence Gene Sequence

In one embodiment, the modification can be made in and inactivate a virulence factor. A virulence factor can be any substance produced by a pathogen that alters host-pathogen interaction by increasing the degree of damage done to the host. Virulence factors are used by pathogens in many ways, including, for example, in cell adhesion or colonization of a niche in the host, to evade the host's immune response, to facilitate entry to and egress from host cells, to obtain nutrition from the host, or to inhibit other physiological processes in the host. Virulence factors can include enzymes, endotoxins, adhesion factors, motility factors, factors involved in complement evasion, scavenging factors and factors that promote biofilm formation.

In some embodiments, the genetic modification is made in a E. coli virulence factor gene such as, without limitation, EHEC-HlyA, fimA, fimF, fimH, neuC, kpsE, sfa, foc, iroN, aer, iha, papC, papGI, papGII, papGIII, hlyC, cnf1, hra, sat, ireA, usp ompT, ibeA, malX, fyuA, irp2, traT, afaD, ipaH, eltB, estA, bfpA, eaeA, espA, aaiC, aatA, TEM, CTX, SHV, csgA, csgB, csgC, csgD, csgE, csgF, csgG, csgH, or genes within T1SS, T2SS, T3SS, T4SS, T5SS, T6SS (secretion systems).

In one embodiment, the method comprises making a genetic modification in the FimH gene in E. coli that results in reverting the following mutations: N70S and S78N associated with AEIC strains³. In a particular embodiment, the genetic modification is made in the FimH gene in E. coli.

In the context of the invention, the FimH gene typically encodes a Type 1 fimbrin D-mannose specific adhesin. The FimH gene is typically of sequence SEQ ID NO: 2319 and typically encodes a protein of sequence SEQ ID NO: 2318.

In one embodiment, the genetic modification is made in the FimH gene in E. coli and preferably results in reverting the mutations N70S and S78N associated with AEIC strains.

In one embodiment, the method comprises making a genetic modification in the blc gene in E. coli that result in reverting the mutation G84E (G251A at the nucleotide level) potentially associated with gut inflammation⁴.

In the context of the invention, the blc gene typically encodes an Outer membrane lipoprotein Blc. The bcl gene is typically of sequence SEQ ID NO: 2321 and typically encodes a protein of sequence SEQ ID NO: 2320.

In one embodiment, the genetic modification is made in the blc gene in E. coli and preferably results in reverting the mutation G84E (G251A at the nucleotide level) potentially associated with gut inflammation.

In some embodiments, the genetic modification is made in a Yersinia pestis virulence factor gene such as, without limitation, yscF (plasmid-borne (pCDI) T3SS external needle subunit).

In some embodiments, the genetic modification is made in a Yersinia pestis virulence factor gene such as, without limitation, yscF (plasmid-borne (pCDI) T3SS external needle subunit).

In some embodiments, the genetic modification is made in a Francisella tularensis virulence factor gene such as, without limitation, fslA.

In some embodiments, the genetic modification is made in a Bacillus anthracis virulence factor gene such as, without limitation, pag (Anthrax toxin, cell-binding protective antigen).

In some embodiments, the genetic modification is made in a Vibrio cholera virulence factor gene such as, without limitation, ctxA and ctxB (cholera toxin), tcpA (toxin co-regulated pilus), and toxT (master virulence regulator).

In some embodiments, the genetic modification is made in a Pseudomonas aeruginosa virulence factor genes such as, without limitation, pyoverdine (e.g., sigma factor pvdS, biosynthetic genes pvdL, pvdI, pvdJ, pvdH, pvdA, pvdF, pvdQ, pvdN, pvdM, pvdO, pvdP, transporter genes pvdE, pvdR, pvdT, opmQ), siderophore pyochelin (e.g., pchD, pchC, pchB, pchA, pchE, pchF and pchG, and toxins (e.g., exoU, exoS and exoT).

In some embodiments, the genetic modification is made in a Klebsiella pneumoniae virulence factor gene such as, without limitation, fimA (adherence, type I fimbriae major subunit), and cps (capsular polysaccharide).

In some embodiments, the genetic modification is made in an Acinetobacter baumannii virulence factor gene such as, without limitation, ptk (capsule polymerization) and epsA (assembly).

In some embodiments, the genetic modification is made in a Salmonella enterica Typhi virulence factor gene such as, without limitation, MIA (invasion, SPI-1 regulator), ssrB (SPI-2 regulator), and those associated with bile tolerance, including efflux pump genes acrA, acrB and tolC.

In some embodiments, the genetic modification is made in a Fusobacterium nucleatum virulence factor gene such as, without limitation, FadA and TIGIT.

In some embodiments, the genetic modification is made in a Bacteroides fragilis virulence factor gene such as, without limitation, bft.

In some embodiments, the genetic modification is made in a Cutibacterium acnes porphyrins gene, a CAMP-factor (CAMP1, CAMP2, CAMP3, CAMP4), Hyaluronate lyase (HYL-IB/II, HYL-IA), Lipases (GehA, GehB), Haemolysins, Sialidases, Endoglycoceramidases, Endo-ß-N-acetylglucosaminidase, Dermatan sulphate adhesin (DsA1, DsA2), Proline-Threonine Repeats (PTRs) or in any virulence factors included on the acne associated genomic loci 1, 2, 3 (plasmid), 4 such as a tight adhesion locus (tad), Streptolysin S-associated genes (sag), nonribosomal peptide synthetases (NRPS) as described in Tomida et al⁵, which is hereby incorporated by reference.

Modification of a Mimic Peptide Gene Sequence

In some embodiments, the genetic modification is made in a mimic peptide gene sequence so that the homology with the human peptide sequence is reduced, and therefore results in the mimic peptide being not recognized anymore by the host immune system. Mimic peptides of particular interest are bacterial mimic peptides that are associated with auto-immune diseases, for example those mentioned in Negi et al.⁶, which are hereby incorporated by reference. Of particular interest are the gene sequences encoding any of the mimic peptides in S1 Table of Negi et al.

In a particular embodiment, the mimic peptide is one of the candidate mimic peptides disclosed in Table 1 below. In a particular embodiment, said mimic peptide is selected from the group consisting of the peptides of sequence SEQ ID NO: 19 to 2313.

In preferred embodiments, the mimic peptide is from Proteobacteria or Firmicutes. Of particular interest are the gene sequences encoding 24 gut bacterial peptides identified by Negi et al. with homology to four human peptides from Low molecular weight phosphotyrosine protein phosphatase, Aldehyde dehydrogenase family 3 member B1, Maleylacetoacetate isomerase and Uracil-DNA glycosylase. These gene sequences can be modified to reduce the homology with the human sequences and prevent cross-reactivity of those recognized by the host immune system with the human counterpart.

In a preferred embodiment, the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene. Preferably, the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification². Preferably the genetic modification is performed in the peptides fragment recognized as epitope by the human immune system leading to a weaker or absence of epitope recognition by the human immune system².

In a preferred embodiment, the genetic modification is in human commensal bacteria encoding a Ro60 ortholog gene. Preferably, the Ro60 protein resulting from the genetic modification shows lower homology with human Ro60 peptide as compared to the original protein. Preferably the genetic modification is performed in the DNA sequence corresponding to peptides fragment recognized as epitope by the human immune system leading to a weaker or absence of epitope recognition by the human immune system. Preferably the human bacterial commensal targeted for genetic modification are: Propionibacterium propionicum, Corynebacterium amycolatum, Actinomyces massiliensis, Bacteroides thetaiotaomicron. Even more preferably the human bacterial commensal targeted for genetic modification is Propionibacterium propionicum ⁷.

In a preferred embodiment, the genetic modification is in human commensal bacterial DNA sequence encoding a peptide that mimic insulin B 9-25, a self-epitope involved in type 1 diabetes⁸. The genetic mutation reduces homology to the insulin B9-25 epitope SHLVEALYLVCGERGFF (SEQ ID NO: 9). In a preferred embodiment, the target bacteria belong to the Firmicutes phylum. In a preferred embodiment, the target gene in the target bacteria is part of the transketolase N superfamily⁸.

In a preferred embodiment, the genetic modification is in Roseburia intestinalis encoding a peptide that mimic the epitope of the autoantigen β₂-glycoprotein I (β₂GPI), a self-epitope involved in antiphospholipid syndrome (APS). The genetic mutation is reducing homology to the T cell (β₂GPI) epitope KVSFFCKNKEKKCSY (SEQ ID NO: 10) and/or B cell epitope VSRGGMRKFIC (SEQ ID NO: 11)²⁸.

Modification of an Antibiotic-Resistance Gene Sequence

In some embodiments, the modification is made in an antibiotic-resistance gene sequence, carried on the chromosome or on a plasmid, to render the bacteria sensitive to an antibiotic without exerting a direct selective pressure on the bacteria in the absence of the related antibiotic.

In some embodiment, the genetic modification is made to revert mutations in endogenous genes, some of which are essential to the bacteria, that confer resistance to antibiotics such as: RpoB rifampicin resistant mutant, 23S rRNA erythromycin resistant mutant, GyrA (fluoro) quinolone resistant mutant, GyrB (fluoro) quinolone resistant mutant, RpsL streptomycin resistant mutant, DHFR trimethoprim resistant mutant, fusA fusidic acid resistant mutant, fmt actinonin resistant mutant, gidB streptomycin resistant mutant, ompR multidrug resistant mutant, marR multidrug resistant mutant, Ion multidrug resistant mutant, mgrB colistin resistant mutant, pmrA colistin resistant mutant, acrR multidrug resistant mutant, cysB amdinocillin resistant mutant, 16S rRNA methyltransferase.

In some embodiments, the antibiotic resistance gene can be, without limitation, GyrB, ParE, ParY, AAC(1), AAC(2′), AAC(3), AAC(6′), ANT(2″), ANT(3″), ANT(4′), ANT(6), ANT(9), APH(2″), APH(3″), APH(3′), APH(4), APH(6), APH(7″), APH(9), ArmA, RmtA, RmtB, RmtC, Sgm, AER, BLA1, CTX-M, KPC, SHV, TEM, BlaB, CcrA, IMP, NDM, VIM, ACT, AmpC, CMY, LAT, PDC, OXA β-lactamase, mecA, Omp36, OmpF, PIB, bla (blaI, blaR1) and mec (mecI, mecR1) operons, Chloramphenicol acetyltransferase (CAT), Chloramphenicol phosphotransferase, Ethambutol-resistant arabinosyltransferase (EmbB), MupA, MupB, Integral membrane protein MprF, Cfr 23S rRNA methyltransferase, Rifampin ADP-ribosyltransferase (Arr), Rifampin glycosyltransferase, Rifampin monooxygenase, Rifampin phosphotransferase, DnaA, RbpA, Rifampin-resistant beta-subunit of RNA polymerase (RpoB), Erm 23S rRNA methyltransferases, Lsa, MsrA, Vga, VgaB, Streptogramin Vgb lyase, Vat acetyltransferase, Fluoroquinolone acetyltransferase, Fluoroquinolone-resistant DNA topoisomerases, Fluoroquinolone-resistant GyrA, GyrB, ParC, Quinolone resistance protein (Qnr), FomA, FomB, FosC, FosA, FosB, FosX, VanA, VanB, VanD, VanR, VanS, Lincosamide nucleotidyltransferase (Lin), EreA, EreB, GimA, Mgt, Ole, Macrolide phosphotransferases (MPH), MefA, MefE, Mel, Streptothricin acetyltransferase (sat), Sul1, Sul2, Sul3, sulfonamide-resistant FoIP, Tetracycline inactivation enzyme TetX, TetA, TetB, TetC, Tet30, Tet31, TetM, TetO, TetQ, Tet32, Tet36, MacAB-TolC, MsbA, MsrA,VgaB, EmrD, EmrAB-TolC, NorB, GepA, MepA, AdeABC, AcrD, MexAB-OprM, mtrCDE, EmrE, adeR, acrR, baeSR, mexR, phoPQ, mtrR, or any antibiotic resistance gene described in the Comprehensive Antibiotic Resistance Database at card. mcmaster.ca/.

In preferred embodiments, the antibiotic is selected from the group consisting of penicillins such as penicillin G, penicillin K, penicillin N, penicillin 0, penicillin V, methicillin, benzylpenicillin, nafcillin, oxacillin, cloxacillin, dicloxacillin, ampicillin, amoxicillin, pivampicillin, hetacillin, bacampicillin, metampicillin, talampicillin, epicillin, carbenicillin, ticarcillin, temocillin, mezlocillin, and piperacillin; cephalosporins such as cefacetrile, cefadroxil, cephalexin, cefaloglycin, cefalonium, cephaloridine, cefalotin, cefapirin, cefatrizine, cefazaflur, cefazedone, cefazolin, cefradine, cefroxadine, ceftezole, cefaclor, cefonicid, cefprozil, cefuroxime, cefuzonam, cefmetazole, cefotetan, cefoxitin, loracarbef, cefbuperazone, cefminox, cefotetan, cefoxitin, cefotiam, cefcapene, cefdaloxime, cefdinir, cefditoren, cefetamet, cefixime, cefmenoxime, cefodizime, cefotaxime, cefovecin, cefpimizole, cefpodoxime, cefteram, ceftamere, cefti buten, ceftiofur, ceftiolene, ceftizoxime, ceftriaxone, cefoperazone, ceftazidime, latamoxef, cefclidine, cefepime, cefluprenam, cefoselis, cefozopran, cefpirome, cefquinome, flomoxef, ceftobiprole, ceftaroline, ceftolozane, cefaloram, cefaparole, cefcanel, cefedrolor, cefempidone, cefetrizole, cefivitril, cefmatilen, cefmepidium, cefoxazole, cefrotil, cefsumide, ceftioxide, cefuracetime, and nitrocefin; polymyxins such as polysporin, neosporin, polymyxin B, and polymyxin E, rifampicins such as rifampicin, rifapentine, and rifaximin; Fidaxomicin; quinolones such as cinoxacin, nalidixic acid, oxolinic acid, piromidic acid, pipemidic acid, rosoxacin, ciprofloxacin, enoxacin, fleroxacin, lomefloxacin, nadifloxacin, norfloxacin, ofloxacin, pefloxacin, rufloxacin, balofloxacin, grepafloxacin, levofloxacin, pazufloxacin, temafloxacin, tosufloxacin, clinafloxacin, gatifloxacin, gemifloxacin, moxifloxacin, sitafloxacin, trovafloxacin, prulifloxacin, delafloxacin, nemonoxacin, and zabofloxacin; sulfonamides such as sulfafurazole, sulfacetamide, sulfadiazine, sulfadimidine, sulfafurazole, sulfisomidine, sulfadoxine, sulfamethoxazole, sulfamoxole, sulfanitran, sulfadimethoxine, sulfametho-xypyridazine, sulfametoxydiazine, sulfadoxine, sulfametopyrazine, and terephtyl; macrolides such as azithromycin, clarithromycin, erythromycin, fidaxomicin, telithromycin, carbomycin A, josamycin, kitasamycin, midecamycin, oleandomycin, solithromycin, spiramycin, troleandomycin, tylosin, and roxithromycin; ketolides such as telithromycin, and cethromycin; fluoroketolides such as solithromycin; lincosamides such as lincomycin, clindamycin, and pirlimycin; tetracyclines such as demeclocycline, doxycycline, minocycline, oxytetracycline, and tetracycline; aminoglycosides such as amikacin, dibekacin, gentamicin, kanamycin, neomycin, netilmicin, sisomicin, tobramycin, paromomycin, and streptomycin; ansamycins such as geldanamycin, herbimycin, and rifaximin; carbacephems such as loracarbef; carbapenems such as ertapenem, doripenem, imipenem (or cilastatin), and meropenem; glycopeptides such as teicoplanin, vancomycin, telavancin, dalbavancin, and oritavancin; lincosamides such as clindamycin and lincomycin; lipopeptides such as daptomycin; monobactams such as aztreonam; nitrofurans such as furazolidone, and nitrofurantoin; oxazolidinones such as linezolid, posizolid, radezolid, and torezolid; teixobactin, clofazimine, dapsone, capreomycin, cycloserine, ethambutol, ethionamide, isoniazid, pyrazinamide, rifabutin, arsphenamine,chloramphenicol, fosfomycin, fusidic acid, metronidazole, mupirocin, platensimycin, quinupristin (or dalfopristin), thiamphenicol, tigecycline, tinidazole, trimethoprim, alatrofloxacin, fidaxomicin, nalidixic acid, rifampin, derivatives and combination thereof.

Modification to a Conserved Sequence

In some embodiments, the modification of the amino-acid sequence is made so that the edited sequence corresponds to an amino-acid sequence encoding for the same or a related protein/function/activity coming from one or multiple different strains from the same species, or from a related species, or from the same genus, or from any other bacteria from the microbiome. The edited sequence can correspond to a paralog, ortholog or analog of the original sequence.

This modification can reduce the potential selective pressure applied to the edited bacteria by ensuring a relatively similar function while not having the same exact amino-acid sequence.

Modification of DNA Sequences Involved in Interactions Between Bacteria and Compounds Administered to or Produced by the Subject or Produced by Other Bacteria

The invention also concerns a method to modify in situ interaction of a bacteria from a microbiome of a subject with a compound administered to or produced by said subject or produced by other bacteria from said subject, by modifying at least one bacterial DNA sequence involved in the interaction of said bacteria with said compound, said bacterial DNA sequence being expressed by a bacterial population of the host microbiome, said method comprising:

contacting the bacterial population with a vector that generates a genetic modification in said at least one DNA sequence of the bacteria, involved in the interaction of said bacteria with said compound, in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence;

wherein the genetic modification of said at least one DNA sequence results in a modification of the interaction of the bacteria with said compound; and

wherein the genetic modification does not lead to the direct death of the bacteria.

By “interaction of a bacteria with a compound administered to or produced by a subject or produced by other bacteria from said subject” is meant any type of interaction, inducing or not a modification in the structure and/or activity of said compound, and involving any component of the bacteria (including enzymes, receptors, channels, sugars, lipids, etc. . . . ) in any location of said bacteria (e.g. at the membrane, capsule, in the cytoplasm, etc). Said interaction of a bacteria with a compound administered to or produced by the subject or produced by other bacteria encompasses (i) modification of said compound by said bacteria and/or (ii) competition between said compound and a molecule produced and/or secreted by said bacteria for a ligand from said subject and/or (iii) binding/adsorption of said compound by said bacteria.

By “ligand” is meant herein a substance binding, in particular specifically binding, to a compound of interest. In the context of the invention, ligands from the subject encompasses receptors, enzymes, immune molecules, etc. . . . , able to bind said compound of interest.

Said compound administered to said subject can be any type of compound such as a drug, a prebiotic, a cosmetic agent, a food supplement, etc. . . . .

Said compound produced by the subject may be, without limitation, bile acids (such as taurocholic acid, glycocholic acid, taurochenodeoxycholic acid, glycochenodeoxycholic acid, deoxycholic acid, lithocholic acid, and derivatives of cholic, chenodeoxycholic and deoxycholic acids), hormones (such as Adrenaline (or epinephrine), Melatonin, Noradrenaline (or norepinephrine), Triiodothyronine, Thyroxine, Dopamine, Prostaglandins, Leukotrienes, Prostacyclin, Thromboxane, Amylin, Anti-Müllerian hormone (or Müllerian-inhibiting factor/hormone), Adiponectin, Adrenocorticotropic hormone (or corticotropin), Angiotensinogen, Angiotensin, Antidiuretic hormone (or vasopressin, arginine vasopressin), Atrial natriuretic peptide (or atriopeptin), Brain natriuretic peptide, Calcitonin, Cholecystokinin, Corticotropin-releasing hormone, Cortistatin, Enkephalin, Endothelin, Erythropoietin, Follicle-stimulating hormone, Galanin, Gastric inhibitory polypeptide, Gastrin, Ghrelin, Glucagon, Glucagon-like peptide-1, Gonadotropin-releasing hormone, Growth hormone-releasing hormone, Hepcidin, Human chorionic gonadotropin, Human placental lactogen, Growth hormone, Inhibin Peptide, Insulin, Insulin-like growth factor (or somatomedin), Leptin, Lipotropin, Luteinizing hormone, Melanocyte stimulating hormone, Motilin, Orexin, Osteocalcin, Oxytocin (or pitocin), Pancreatic polypeptide, Parathyroid hormone, Pituitary adenylate cyclase-activating peptide, Prolactin (or leuteotropic hormone), Prolactin-releasing hormone, Relaxin, Renin, Secretin, Somatostatin (or growth hormone-inhibiting hormone or growth hormone release-inhibiting hormone or somatotropin release-inhibiting factor or somatotropin release-inhibiting hormone), Thrombopoietin, Thyroid-stimulating hormone (or thyrotropin), Thyrotropin-releasing hormone, Vasoactive intestinal peptide, Guanylin, Uroguanylin, Testosterone, Dehydroepiandrosterone, Androstenedione, Di hydrotestosterone, Aldosterone, Estradiol, Estrone, Estriol, Cortisol, Progesterone, Calcitriol or Calcidiol) or perspiration compounds.

In a particular embodiment, the invention concerns a method to modify the metabolism of a given drug in a host treated with said drug, by modifying at least one drug-targeting enzyme expressed by a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for a drug-metabolizing gene product, in particular a drug-targeting enzyme, expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the gene coding for the drug-metabolizing gene protein, in particular the drug-targeting enzyme, results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

By “drug metabolism” is meant herein the biotransformation of pharmaceutical substances in the body. In the context of the invention, drug metabolism encompasses both the pathway leading to the elimination of the drug and the more general evolution of the drug activity in the subject one administered to said subject.

Said modification of the metabolism of a given drug may be selected from the group consisting of preventing transformation of the given drug into a toxic compound for the host, preventing hydrolysis of the given drug thus leading to a prolonged activity of said drug, an enzymatic modification of the given drug leading to an increased and/or prolonged activity of said drug, a transformation of said given drug into an active or more active compound, a modification preventing reactivation of detoxified compounds from a given drug.

Said given drug may be selected from the group consisting of Nicardipine.HCl, Risperidone, Tolcapone, Azathioprine, Entacapone, Exemestane, Nimodipine, Capsaicin, Dexamethasone, Ethacrynic Acid, Rifampin (Rifampicin), Sulindac, Vorinostat, Dolasetron, Mycophenolate Mofetil, Zidovudine (3′-Azido-3′-Deoxythymidine), Allopurinol, Betamethasone, Bisacodyl, Estradiol, Famciclovir, Flutamide, Hydrocortisone, Hydrocortisone Acetate, Methylprednisolone, Metronidazole, Nabumetone, Pantoprazole, Prednisolone, Progesterone, Prednisone, Spironolactone, Sulfasalazine, Tinidazole, Fluoxetine.HCl, Misoprostol, Megestrol Acetate, Capecitabine, Chenodiol (Chenodeoxycholic Acid), Clofazimine, Clonazepam, Cortisone Acetate, Dantrolene.Na, Duloxetine, Fludrocortisone Acetate, Iloperidone, Lorazepam, Nilutamide, Nitisinone, Nitrofurantoin, Oxazepam, Paliperidone, Prasugrel, Probenecid, Rifabutin, Sulfamethoxazole, Ursodiol, Omeprazole, Tenatoprazole, Artemisinin, Danazol, Olmesartan medoxomil, Phenazopyridine, Nitrendipine, Racecadrotil, Fenofibrate, Fluphenazine, Telmisartan, Benzbromarone, Oxethazaine, Mefloquine, Quinacrine, Pimozide, Loxapine succinate, Cyclobenzaprine, Ethopropazine, Promethazine, Clemizole and Pyrimethamine.

Said given drug may further be selected from the group consisting of abacavir sulfate, acebutolol, acecainide, alfuzosin, almotriptan, alprenolol, amantadine, aminoglutethimide, amisulpride, anagrelide, anastrozole, antazoline phosphate, apomorphine, artemisinin, atenolol, atorvastatin calcium, azatadine maleate, bambuterol, Benazepril, benzbromarone, benzthiazide, betamethasone acetate, betamethasone valerate, betaxalol, bezafibrate, bicalutamide, biperiden, bisacodyl, bisoprolol fumarate, bromocriptine mesylate, budesonide, bupropion, buramate, buspirone, camylofine dihydrochloride, capecitabine, carbetapentane citrate, carbinoxamine maleate, carisoprodol, Carvedilol, celecoxib, cetirizine, chlormezanone, cimetidine, citalopram hydrobromide, clemastine fumarate, clemizole, clenbuterol, clidinium bromide, clonidine, clopidogrel sulfate, Clozapine, colchicine, cyclobenzaprine, cyclophosphamide, cyproterone acetate, dabigatran etexilate mesylate, danazol, darifenacin hydrobromide, dasatinib, deflazacort, desvenlafaxine succinate, dexamethasone, dextromethorphan hydrobromide, diacetamate, Dicyclomine, diflorasone diacetate, digitoxin, digoxin, diltiazem, diperodon, diphenylpyraline, Dipyridamole, disopyramide phosphate, domperidone, doxazosin mesylate, doxepin, doxylamine succinate, drospirenone, duloxetine, eletriptan hydrobromide, enalapril maleate, Entacapone, ergonovine maleate, ergotamine tartrate, eszopiclone, ethopropazine, ethoxzolamide, ethynodiol diacetate, etodolac, ezetimibe, famciclovir, famprofazone, febuxostat, fenofibrate, fenspiride, fexofenadine, finasteride, fluconazole, fluoxetine, fluphenazine, fluvoxamine maleate, galantamine, gliclazide, glipizide, griseofulvin, guanfacine, haloperidol, hyoscyamine, idebenone, imatinib, indapamide, indomethacin, Irbesartan, irsogladine maleate, isradipine, itraconazole, ketorolac tromethamine, ketotifen fumarate, labetalol, lamotrigine, letrozole, levamisole, levonorgestrel, linagliptin, lofexidine, Loperamide, losartan, lovastatin, loxapine succinate, mebendazole, mebhydrolin naphthalenesulfonate, mefloquine, megestrol acetate, melphalan, memantine, metaxalone, Methocarbamol, methoxsalen, methsuximide, methylphenidate, methysergide maleate, meticrane, metitepine maleate, metoclopramide, metolazone, metoprolol tartrate, mevastatin, mianserin, mifepristone, milnacipran, mycophenolate mofetil, nadolol, nafronyl oxalate, naftopidil, naloxone, naproxen(+), nateglinide, nefazodone, nefopam, neostigmine bromide, nevirapine, nicergoline, nitrendipine, nizatidine, norethindrone acetate, Norgestimate, noscapine, olanzapine, olmesartan medoxomil, omeprazole, orphenadrine citrate, oxaprozin, oxcarbazepine, oxethazaine, oxybutynin chloride, Paclitaxel, paliperidone, pantoprazole, papaverine, paroxetine, penbutolol sulfate, pentoxifylline, pergolide mesylate, pericyazine, perindopril erbumine, phenacetin, Phenazopyridine, phenytoin sodium, pidotimod, pimozide, pitavastatin calcium, Pranoprofen, prazosin, prednisone, pridinol methanesulfonate, primaquine phosphate, Procarbazine, promethazine, pyrimethamine, quetiapine, quinacrine, quinapril, quinine sulfate, racecadotril, ramelteon, ramipril, ranitidine, ranolazine, rebamipide, repaglinide, Reserpine, riluzole, rimantadine, risperidone, ritonavir, rivastigmine tartrate, rizatriptan benzoate, ropinirole, rosiglitazone maleate, rosuvastatin calcium, roxatidine acetate, sertraline, sildenafil citrate, solifenacin succinate, sotalol, spiperone, sulfasalazine, sulfinpyrazone, sulindac, sulpiride, sumatriptan succinate, tacrine, tacrolimus, tadalafil, tamsulosin hydrchloride, tegaserod maleate, telmisartan, tenatoprazole, tenoxicam, terazosin, terbinafine, thiabendazole, thiothixene, tiapride, timolol maleate, tinidazole, Tolazamide, topotecan, trandolapril, tranilast, trazodone, trihexyphenidyl, trimebutine maleate, trimetazidine dihydrochloride, trimethobenzamide, trimipramine maleate, Triprolidine, tropisetron, trospium chloride, valsartan, venlafaxine, verapamil, vilazodone, Vinpocetine, voriconazole, warfarin, zaleplon, zidovudine [azt], ziprasidone mesylate and zolpidem.

In a particular embodiment, in particular when said given drug is selected from the list of drugs above, said drug-metabolizing gene product is selected from the group consisting of the gene products encoded by the nucleic acid sequences listed in Table 2 below, or is a gene product the amino acid sequence of which is at least 90% identical, in particular at least 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identical to one of the gene products encoded by the nucleic acid sequences listed in Table 2 below.

In a particular embodiment, in particular when said given drug is selected from the list of drugs above, said drug-metabolizing gene product is expressed or secreted by a bacteria selected from the group consisting of the bacteria recited in Table 2 below.

In a particular embodiment, said drug-targeting enzyme is selected from enzymes having oxidation, deamination, isomerization, esterification, condensation, reduction, hydrolysis and/or rearrangement activities. In a particular embodiment, said drug-targeting enzyme is selected from β-glucuronidases, nitroreductases and sulfoxide reductases.

In a particular embodiment, said given drug is dantrolene, clonazepam, and/or nicardipine, and said drug-targeting enzyme is an enzyme having nitro-reduction activity.

In an alternative embodiment, said given drug is risperidone, and said drug-targeting enzyme is an enzyme having hydrolysis activity, in particular an enzyme hydrolysing the isoxazole moiety of risperidone.

In an alternative embodiment, said given drug is sulfasalazine, and said drug-targeting enzyme is an enzyme having azoreduction activity.

In an alternative embodiment, said given drug is digoxin, and said drug-targeting enzyme is cytochrome glycoside reductase, said bacteria expressing said drug-targeting enzyme being preferably Eggerthella lenta.

In an alternative embodiment, said given drug is levodopa (L-DOPA), and said drug-targeting enzyme is tyrosine decarboxylase, preferably expressed by Enterococcus faecalis, Enterococcus faecium and/or Lactobacillus brevis and/or dopamine dehydrolase, preferably expressed by Eggerthella lenta. In a more particular embodiment, said genetic modification in the DNA sequence encoding said tyrosine decarboxylase induces inactivation of said enzyme, enabling preventing decarboxylation, and thereby inactivation, of L-DOPA by said enzyme, in subjects suffering from Parkinson's disease and treated with levodopa.

In another embodiment, said given drug is levodopa (L-DOPA), and said drug-targeting enzyme is DHPAA synthase, preferably expressed by Clostridium sporogenes. In a more particular embodiment, said genetic modification in the DNA sequence encoding DHPAA synthase induces inactivation of said enzyme, enabling preventing deamination of L-DOPA, and thereby transformation of L-DOPA into 3,4-dihydroxyphenylacetaldehyde (DHPAA), and preventing and/or reducing constipation in subjects suffering from Parkinson's disease and treated with levodopa.

In an alternative embodiment, said given drug is gemcitabine, and said drug-targeting enzyme is cytidine deaminase, said bacteria expressing said drug-targeting enzyme being preferably Escherichia coli and/or Gammaproteobacteria.

In an alternative embodiment, said given drug is prontosil, and said drug-targeting enzyme is an enzyme converting prontosil into p-aminobenzenesulfonamide by azo-reduction.

In an alternative embodiment, said given drug is selected from sulfasalazine, ipsalazide and balsalazide, and said drug-targeting enzyme is an enzyme converting said drug into 5-aminosalicylic acid.

In an alternative embodiment, said given drug is a non-steroidal anti-inflammatory drug, and said drug-targeting enzyme is a β-glucuronidase.

In a particular embodiment, said compound is L-DOPA, and said modification of the interaction is a modification in the adsorption of L-DOPA by Helicobacter pylori, typically by modifying bacterial adhesins from H. pylori involved in said adsorption.

In a particular embodiment, said compound is acetaminophen and said modification of the interaction is a modification in the competition between acetaminophen and p-cresol produced by C. difficile, typically by modifying DNA sequences involved in the production and/or secretion of p-cresol by C. difficile.

The present invention thus also concerns a method of treatment of a subject in need thereof, comprising

-   -   administering a drug to said subject, and     -   before, simultaneously with, or after said administration of         said drug, administering to said subject a vector encoding         enzymes or systems for inducing genetic modifications in a DNA         sequence coding for a drug-targeting enzyme expressed or         secreted by the bacteria in at least some of the bacteria of         said population without introducing a double strand break in the         DNA sequence,     -   wherein the genetic modification of the DNA sequence coding for         the drug-targeting enzyme results in a modification of the drug         metabolism in the subject;     -   wherein genetic modification does not lead to the direct death         of the bacteria.

The present invention thus also concerns a pharmaceutical combination comprising a drug and a vector encoding enzymes or systems for inducing genetic modifications in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence, for simultaneous, sequential or separate use in the treatment of a subject.

The invention also concerns a method for increasing the efficacy of a drug treatment in a subject in need thereof, comprising:

-   -   administering a drug to said subject, and     -   before, simultaneously with, or after said administration of         said drug, administering to said subject a vector encoding         enzymes or systems for inducing genetic modifications in a DNA         sequence coding for a drug-targeting enzyme expressed or         secreted by the bacteria in at least some of the bacteria of         said population without introducing a double strand break in the         DNA sequence,     -   wherein the genetic modification of the DNa sequence coding for         the drug-targeting enzyme results in a modification of the drug         metabolism in the subject;     -   wherein genetic modification does not lead to the direct death         of the bacteria.         Lack of Inhibition of Bacterial Growth

Bacteria with the genetic modification can be assessed for any inhibition of bacterial growth by comparison with the same bacteria without the genetic modification either in vitro or in vivo. This is preferably performed by assessing the percentage of bacteria with and without the genetic modification at at least two timepoints and determining that the bacteria with the genetic modification do not have a reduced percentage at the later time point.

Comparison in vitro can be performed by growing the bacteria in solid or liquid culture and determining the percentages of each type of bacteria over time. The percentages can be determined by routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

Comparison in vivo can be performed by collecting samples (e.g., stool or swab) over time and determining the percentages of each type of bacteria over time. The percentages can be determined by routine diagnostic procedures employing immunodetection (e.g. ELISA), nucleic acid amplification (e.g., PCR), High Resolution Melting, and nucleic acid sequencing.

Preferred percentages of bacteria with the genetic modification are at least 70%, 80%, 90%, 95%, 97%, 98%, 99%, 99.9%, 99.99%, and 100%.

Enzymes and Systems for Inducing Modifications

In some embodiments, the genetic modification is made with one or more of the following enzymes and systems.

Cytosine base editors (CBE) and Adenosine base editors (ABE), as described in Rees et al.⁹ which is hereby incorporated by reference.

So far there are seven types of DNA base editors described:

-   -   Cytosine Base Editor (CBE) that convert C:G into T:A³²     -   Adenine Base Editor (ABE) that convert A:T into G:C³³     -   Cytosine Guanine Base Editor (CGBE) that convert C:G into         G:C^(29,30)     -   Cytosine Adenine Base Editor (CABE) that convert C:G into A:T³¹     -   Adenine Cytosine Base Editor (ACBE) that convert A:T into C:G³⁴     -   Adenine Thymine Base Editor (ATBE) that convert A:T into T:A³⁵     -   Thymine Adenine Base Editor (TABE) that convert T:A into         A:T³⁶⁻³⁸

Base editors differ in the base modification enzymes. CBE rely on ssDNA cytidine deaminase among which: APOBEC1, rAPOBEC1, APOBEC1 mutant or evolved version (evoAPOBEC1), and APOBEC homologs (APOBEC3A (eA3A), Anc689), Cytidine deaminase 1 (CDA1), evoCDA1, FERNY, evoFERNY.

ABE rely on deoxyadenosine deaminase activity of a tandem fusion TadA-TadA* where TadA* is an evolved version of TadA, an E. coli tRNA adenosine deaminase enzyme, able to convert adenosine into Inosine on ssDNA. TadA* include TadA-8a-e and TadA-7.10.

Except from base modification enzyme there has been also modifications implemented to base editor to increase editing efficacy, precision and modularity:

-   -   the addition of one or two uracil DNA glycosylase inhibitor         domain (UGI) to prevent base excision repair mechanism to revert         base edition     -   the addition of Mu-GAM that decrease insertion-deletion rate by         inhibiting Non-homologous end joining mechanism in the cell         (NHEJ)     -   the use of nickase active Cas9 (nCas9 D10A) that, by creating         nicks on the non-edited strand favors its repair and         consequently the fixation of the edited base.     -   the use of diverse Cas proteins from for example different         organisms, mutants with different PAM motifs or different         fidelity or different family (e.g. Cas12a).

Non-limiting examples of DNA-based editor proteins include BE1, BE2, BE3, BE4, BE4-GAM, HF-BE3, Sniper-BE3, Target-AID, Target-AID-NG, ABE, EE-BE3, YE1-BE3, YE2-BE3, YEE-BE3, BE-PLUS, SaBE3, SaBE4, SaBE4-GAM, Sa(KKH)-BE3, VQR-BE3, VRER-BE3, EQR-BE3, xBE3, Cas12a-BE, Ea3A-BE3, A3A-BE3, TAM, CRISPR-X, ABE7.9, ABE7.10, ABE7.10*, xABE, ABESa, VQR-ABE, VRER-ABE, Sa(KKH)-ABE, ABE8e, SpRY-ABE, SpRY-CBE, SpG-CBE4, SpG-ABE, SpRY-CBE4, SpCas9-NG-ABE, SpCas9-NG-CBE4, enAsBE1.1, enAsBE1.2, enAsBE1.3, enAsBE1.4, AsBE1.1, AsBE1.4, CRISPR-Abest, CRISPR-Cbest, eA3A-BE3, AncBE4.

Cytosine Guanine Base Editors (CGBE) consist of a nickase CRISPR fused to:

-   -   a. A cytosine deaminase (rAPOBEC) and base excision repair         proteins (e.g. rXRCC1).^(29,41)     -   b. A rat APOBEC1 variant (R33A) protein and an E. coli-derived         uracil DNA N-glycosylase (eUNG).³⁰

Cytosine Adenine Base Editors (CABE) consist of a Cas9 nickase, a cytidine deaminase (e.g. AID), and a uracil-DNA glycosylase (Ung).³¹

ACBE include a nucleic acid programmable DNA-binding protein and an adenine oxidase.34

ATBE consist of a Cas9 nickase and one or more adenosine deaminase or an oxidase domain.³⁵

TABE consist of a Cas9 nickase and an adenosine methyltransferase, a thymine alkyltransferase, or an adenosine deaminase domain.³⁶⁻³⁸

Base editor molecules can also consist of two or more of the above listed editor enzymes fused to a Cas protein (e.g. combination of an ABE and CBE). These biomolecules are named dual base editors and enable the editing of two different bases.^(39,40)

In a particular embodiment, the genetic modification is made with a Cytosine base editor (CBE) and/or an Adenosine base editor (ABE) as defined above.

Prime editors (PE), as described in Anzalone et al.¹⁰ which is hereby incorporated by reference, consist of a nCas9 fused to a reverse transcriptase used in combination with a prime editing RNA (pegRNA; a guide RNA that includes a template region for reverse transcription).

Prime Editing allows introduction of insertions, deletions (indels), and 12 base-to-base conversions. Prime editing relies on the ability of a reverse transcriptase (RT), fused to a Cas nickase variant, to convert RNA sequence brought by a prime editing guide RNA (pegRNA) into DNA at the nick site generated by the Cas protein. The DNA flap generated from this process is then included or not in the targeted DNA sequence.

Prime editing systems include:

-   -   a Cas nickase variant such as Cas9-H840A fused to a reverse         transcriptase domain such as M-MLV RT or its mutant version         (M-MLV RT(D200N), M-MLV RT(D200N/L603W), M-MLV         RT(D200N/L603W/T330P/T306K/W313F)     -   a prime editing guide RNA (pegRNA)

To favor editing, the prime editing system can include the expression of an additional sgRNA targeting the Cas nickase activity towards the non-edited DNA strand ideally only after the resolution of the edited strand flap by designing the sgRNA to anneal with the edited strand but not with the original strand.

Non-limiting examples of prime editing systems include PE1, PE1-M1, PE1-M2, PE1-M3, PE1-M6, PE1-M15, PE1-M3inv, PE2, PE3, PE3b.

Cas9 Retron preciSe Parallel Editing via homologY (‘CRISPEY’), a retron RNA fused to the sgRNA and expressed together with Cas9 and the retron proteins including at least the reverse transcriptase¹¹.

The SCRIBE strategy: a retron system expressed in combination with a recombinase promoting the recombination of single stranded DNA, also known as single stranded annealing proteins (SSAPs)¹². Such recombinases include but are not limited to phage recombinases such as lambda red, recET, Sak, Sak4, and newly described SSAPs described in Wannier et al¹³ which is hereby incorporated by reference.

The targetron system based on group II introns described in Karberg et al.¹⁴, which is hereby incorporated by reference, and which has been adapted to many bacterial species.

Other retron based gene targeting approaches are described in Simon et al.¹⁵ which is hereby incorporated by reference.

CRISPR-Cas. The CRISPR system contains two distinct elements, i.e. i) an endonuclease, in this case the CRISPR associated nuclease (Cas or “CRISPR associated protein”) and ii) a guide RNA. Depending on the type of CRISPR system, the guide RNA may be in the form of a chimeric RNA which consists of the combination of a CRISPR (crRNA) bacterial RNA and a tracrRNA (trans-activating RNA CRISPR)¹⁶. The guide RNA combines the targeting specificity of the crRNA corresponding to the “spacing sequences” that serve as guides to the Cas proteins, and the conformational properties of the tracrRNA in a single transcript. When the guide RNA and the Cas protein are expressed simultaneously in the cell, the target genomic sequence can be permanently interrupted (and causing disappearance of the targeted and surrounding sequences and/or cell death, depending on the location) or modified. The modification may be guided by a repair matrix.

The CRISPR system includes two main classes depending on the nuclease mechanism of action:

-   -   Class 1 is made of multi-subunit effector complexes and includes         type I, Ill and IV     -   Class 2 is made of single-unit effector modules, like Cas9         nuclease, and includes type II (II-A, II-B, II-C, II-C variant),         V (V-A, V-B, V-C, V-D, V-E, V-U1, V-U2, V-U3, V-U4, V-U5) and VI         (VI-A, VI-B1, VI-B2, VI-C, VI-D)

The sequence of interest according to the present invention preferably comprises a nucleic acid sequence encoding Cas protein. A variety of CRISPR enzymes are available for use as a sequence of interest on the vector according to the present invention. In some embodiments, the CRISPR enzyme is a Type II CRISPR enzyme, a Type II-A or Type II-B CRISPR enzyme. In another embodiment, the CRISPR enzyme is a Type I CRISPR enzyme or a Type III CRISPR enzyme. In some embodiments, the CRISPR enzyme catalyzes DNA modification. In some other embodiments, the CRISPR enzyme catalyzes RNA modification. For instance, Cas13-deaminase fusions have been used for RNA base editing thus modifying RNA¹⁷. In one embodiment, the CRISPR enzymes may be coupled to a guide RNA or single guide RNA (sgRNA). In certain embodiments, the guide RNA or sgRNA targets a DNA sequence or gene selected from the group consisting of an antibiotic resistance gene, virulence protein or factor gene, toxin protein or factor gene, a bacterial receptor gene, a membrane protein gene, a structural protein gene, a secreted protein gene, a gene expressing resistance to a drug in general and a gene causing a deleterious effect to the host. Preferably, the CRISPR enzyme does not make a double strand break. In some embodiments, the CRISPR enzyme makes a single strand break or nicks. In some embodiments, the CRISPR enzyme does not make any break in the DNA or RNA. In one embodiment, a Cas13-deaminase fusion is used to base edit an RNA.

The sequence of interest may comprise a nucleic acid sequence encoding a guide RNA or sgRNA to guide the Cas protein endogenous to the targeted bacteria, alone or in combination with a Cas protein and/or a guide RNA encoded by the vector.

Non-limiting examples of Cas proteins as part of a multi-subunit effector or as a single-unit effector include Cas1, Cas1B, Cas2, Cas3, Cas4, Cas5, Cas6, Cas7, Cas8, Cas9 (also known as Csn1 and Csx12), Cas10, Cas11 (SS), Cas12a (Cpf1), Cas12b (C2c1), Cas12c (C2c3), Cas12d (CasY), Cas12e (CasX), C2c4, C2c8, C2c5, C2c10, C2c9, Cas13a (C2c2), Cas13b (C2c6), Cas13c (C2c7), Cas13d, Csa5, Csc1, Csc2, Cse1, Cse2, Csy1, Csy2, Csy3, Csf1, Csf2, Csf3, Csf4, Csm1, Csm2, Csm3, Csm4, Csm5, Csm6, Cmr1, Cmr3, Cmr4, Cmr5, Cmr6, Csn2, Csb1, Csb2, Csb3, Csx17, Csx14, Csx10, Csx16, CsaX, Csx13, Csx1, Csx15, SdCpf1, CmtCpf1, TsCpf1, CmaCpf1, PcCpf1, ErCpf1, FbCpf1, UbcCpf1, AsCpf1, LbCpf1, homologues thereof, orthologues thereof, variants thereof, or modified versions thereof. In some embodiments, the CRISPR enzyme cleaves both strands of the target nucleic acid at the Protospacer Adjacent Motif (PAM) site.

In various embodiments, the nucleic acid of interest encodes fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and a deaminase domain. In some embodiments, the fusion protein comprises Cas9 and a cytosine deaminase enzyme, such as APOBEC enzymes, or adenosine deaminase enzymes, such as ADAT enzymes, for example as disclosed in U.S. Patent Publ. 2015/0166980, which is hereby incorporated by reference. In one embodiment, the deaminase is an ACF1/ASE deaminase.

In various embodiments, the APOBEC deaminase is selected from the group consisting of APOBEC1 deaminase, APOBEC2 deaminase, APOBEC3A deaminase, APOBEC3B deaminase, APOBEC3C deaminase, APOBEC3D deaminase, APOBEC3F deaminase, APOBEC3G deaminase, and APOBEC3H deaminase. In various embodiments, the fusion protein comprises a Cas9 domain, a cytosine deaminase domain, and a uracil glycosylase inhibitor (UGI) domain.

In one embodiment, the deaminase is an adenosine deaminase that deaminate adenosine in DNA, for example as disclosed in U.S. Pat. No. 10,113,163, which is hereby incorporated by reference. In some embodiments, the fusion proteins further comprise an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN), for example as disclosed in U.S. Pat. No. 10,113,163. In various embodiments, the nucleic acid of interest encodes fusion proteins comprising a catalytically impaired Cas9 endonuclease fused to an engineered reverse transcriptase, programmed with a prime editing guide RNA (pegRNA) that both specifies the target site and encodes the desired edit, for example as described in Anzalone et al.¹⁰, which is hereby incorporated by reference.

In a particular embodiment, the CRISPR enzyme is any Cas9 protein, for instance any naturally-occurring bacterial Cas9 as well as any variants, homologs or orthologs thereof.

By “Cas9” is meant a protein Cas9 (also called Csn1 or Csx12) or a functional protein, peptide or polypeptide fragment thereof, i.e. capable of interacting with the guide RNA(s) and of exerting the enzymatic activity (nuclease) which allows it to perform the double-strand cleavage of the DNA of the target genome. “Cas9” can thus denote a modified protein, for example truncated to remove domains of the protein that are not essential for the predefined functions of the protein, in particular the domains that are not necessary for interaction with the gRNA (s). Preferably, the Cas9 is a dCas9 (dead-Cas9) or nCas9 (nickase Cas9) lacking double strand DNA cleavage activity.

The sequence encoding Cas9 (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas9 protein¹⁸⁻²⁰. Examples of Cas9 proteins useful in the present invention include, but are not limited to, Cas9 proteins of Streptococcus pyogenes (SpCas9), Streptococcus thermophiles (St1Cas9, St3Cas9), Streptococcus mutans, Staphylococcus aureus (SaCas9), Campylobacter jejuni (CjCas9), Francisella novicida (FnCas9) and Neisseria meningitides (NmCas9).

The sequence encoding Cpf1 (Cas12a) (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cpf1 (Cas12a) protein^(18,19). Examples of Cpf1(Cas12a) proteins useful in the present invention include, but are not limited to, Cpf1(Cas12a) proteins of Acidaminococcus sp, Lachnospiraceae bacteriu and Francisella novicida.

The sequence encoding Cas13a (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas13a (C2c2) protein²¹. Examples of Cas13a (C2c2) proteins useful in the present invention include, but are not limited to, Cas13a (C2c2) proteins of Leptotrichia wadei (LwaCas13a).

The sequence encoding Cas13d (the entire protein or a fragment thereof) as used in the context of the invention can be obtained from any known Cas13d protein (Yan et al. (2018) Mol Cell 70(2):327-339).Examples of Cas13d proteins useful in the present invention include, but are not limited to, Cas13d proteins of Eubacterium siraeum and Ruminococcus sp.

In some embodiments, other programmable nucleases can be used. These include an engineered TALEN (Transcription Activator-Like Effector Nuclease) and variants, engineered zinc finger nuclease (ZFN) variants, natural, evolved or engineered meganuclease or recombinase variants, and any combination or hybrids of programmable nucleases. Thus, the programmable nucleases provided herein may be used to selectively modify DNA encoding a DNA sequence or gene of interest such as, for example, a toxin gene, a virulence factor gene, an antibiotic resistance gene, a remodeling gene or a modulatory gene (cf. WO2014124226 and US2015/0064138).

In some embodiments, the genetic modification is made at the RNA level. RNA base editing is based on the same principle as DNA base editing: an enzyme catalyzing the conversion of a RNA base into another must be brought close to the target base to perform its conversion locally. In one embodiment, the enzyme used for RNA editing is an adenosine deaminase from ADAR family that converts Adenosine into Inosine in dsRNA structure. Several seminal studies used this specificity for dsRNA and fused the ADAR deaminase domain (ADAR_(DD)) to an antisense oligo in order to program local RNA base editing. More recently the ability of some CRISPR-Cas systems to bind RNA molecules was repurposed into RNA editing. Using catalytically dead Cas13b enzyme (dPspCas13b) fused to a hyperactive mutant of ADAR2 deaminase domain (ADAR2_(DD)-E488Q for REPAIRv1 and ADAR2_(DD)-E488Q-T375G for REPAIRv2) Cox et al improved specificity and efficiency compare to previous RNA editing strategies.

Non-limiting examples of RNA based editor proteins include REPAIRv1, REPAIRv2.

Vectors for Inducing Modifications

In various embodiments, one or more of the following vectors can be used to introduce the exogenous enzyme that results in a genetic modification:

-   -   Engineered phages     -   Engineered bacteria     -   Plasmid (e.g., a conjugative plasmid capable of transfer into a         host cell), phage, phagemid or prophage.     -   Each vector may be as described above, eg, a phage capable of         infecting a host cell or conjugative plasmid capable of         introduction into a host cell, which can be introduced either by         a phage particle (engineered or wild-type phage) via injection         or by a donor bacteria via conjugation. In an example, the         vectors are in combination with an antibiotic agent (e.g., a         beta-lactam antibiotic) and/or with any other agent.     -   A bacteriophage for modifying a naturally occurring bacteria in         situ comprising a nucleic acid encoding a gene editing         enzyme/system for transformation of a target bacteria in a mixed         bacterial population wherein said gene editing enzyme/system         modifies the genome of said target bacteria, but does not lead         to the death of the target bacteria.

The invention encompasses the use of these vectors wherein the gene editing enzyme/system targets a DNA sequence or gene within the target bacteria encoding a protein which is directly or indirectly responsible for a disease or disorder.

In a particular embodiment, said vector does not replicate in the targeted bacteria.

Origin of Replication

In preferred embodiments the DNA in the vector will comprise an origin of replication for the targeted bacteria. Origins of replication known in the art have been identified from species-specific plasmid DNAs (e.g. ColE1, RI, pT181, pSC101, pMB1, R6K, RK2, p15a and the like), from bacterial virus (e.g. φX174, M13, F1 and P4) and from bacterial chromosomal origins of replication (e.g. oriC).

In one embodiment, the vector according to the invention comprises a bacterial origin of replication that is functional in the targeted bacteria.

Alternatively, the vector according to the invention does not comprise any functional bacterial origin of replication or contain an origin of replication that is inactive in the targeted bacteria. Thus, the vector of the invention cannot replicate by itself once it has been introduced into a bacterium by the bacterial virus particle.

In one embodiment, the origin of replication on the vector to be packaged is inactive in the targeted bacteria, meaning that this origin of replication is not functional in the bacteria targeted by the bacterial virus particles, thus preventing unwanted vector replication.

In one embodiment, the vector comprises a bacterial origin of replication that is functional in the bacteria used for the production of the bacterial virus particles.

Bacteria-Specific Origins of Replication

Plasmid replication depends on host enzymes and on plasmid-controlled cis and trans determinants. For example, some plasmids have determinants that are recognized in almost all gram-negative bacteria and act correctly in each host during replication initiation and regulation. Other plasmids possess this ability only in some bacteria (Kues, U and Stahl, U 1989 Microbiol Rev 53:491-516).

Plasmids are replicated by three general mechanisms, namely theta type, strand displacement, and rolling circle (reviewed by Del Solar et al. 1998 Microhio and Molec Biol. Rev 62:434-464) that start at the origin of replication. This replication origins contain sites that are required for interactions of plasmid and/or host encoded proteins.

Origins of replication used on the vector of this invention may be moderate copy number, such as ColE1 ori from pBR322 (15-20 copies per cell) or the R6K plasmid (15-20 copies per cell) or may be high copy number, e.g. pUC oris (500-700 copies per cell), pGEM oris (300-400 copies per cell), pTZ oris (>1000 copies per cell) or pBluescript oris (300-500 copies per cell).

In one embodiment, the bacterial origin of replication is selected in the group consisting of ColE1, pMB1 and variants (pBR322, pET, pUC, etc), p15a, ColA, ColE2, pOSAK, pSC101, R6K, IncW (pSa etc), IncFII, pT181, P1, F IncP, IncC, IncJ, IncN, IncP1, IncP4, IncQ, IncH11, RSF1010, CloDF13, NTP16, R1, f5, pPS10, pC194, pE194, BBR1, pBC1, pEP2, pWVO1, pLF1311, pAP1, pWKS1, pLS1, pLS11, pUB6060, pJD4, pIJ101, pSN22, pAMbeta1, pIP501, pIP407, ZM6100(Sa), pCU1, RA3, pMOL98, RK2/RP4/RP1/R68, pB10, R300B, pRO1614, pRO1600, pECB2, pCM1, pFA3, RepFIA, RepFIB, RepFIC, pYVE439-80, R387, phasyl, RA1, TF-FC2, pMV158 and pUB113.

More preferably, the bacterial origin of replication is an E. coli origin of replication selected in the group consisting of ColE1, pMB1 and variants (pBR322, pET, pUC, etc), p15a, ColA, ColE2, pOSAK, pSC101, R6K, IncW (pSa etc), IncFII, pT181, P1, F IncP, IncC, IncJ, IncN, IncP1, IncP4, IncQ, IncH11, RSF1010, CloDF13, NTP16, R1, f5, pPS10.

More preferably, the bacterial origin of replication is selected in the group consisting of pC194, pE194, BBR1, pBC1, pEP2, pWVO1, pLF1311, pAP1, pWKS1, pLS1, pLS11, pUB6060, pJD4, pIJ101, pSN22, pAMbeta1, pIP501, pIP407, ZM6100(Sa), pCU1, RA3, pMOL98, RK2/RP4/RP1/R68, pB10, R300B, pRO1614, pRO1600, pECB2, pCM1, pFA3, RepFIA, RepFIB, RepFIC, pYVE439-80, R387, phasyl, RA1, TF-FC2, pMV158 and pUB113.

Even more preferably, the bacterial origins of replication are ColE1 and p15a.

In one embodiment, the bacterial origin of replication is functional in Propionibacterium and Cutibacterium more specifically in Propionibacterium freudenreichii and Cutibacterium acnes and is selected from the group consisting of pLME108, pLME106, p545, pRGO1, pZGX01, pPG01, pYS1, FRJS12-3, FRJS25-1, pIMPLE-HL096PA1,A_15_1_R1.

Phage Origin of Replication

The vector according to the invention may comprise a phage replication origin which can initiate, with complementation in cis or in trans of a complete or modified phage genome, the replication of the payload for later encapsulation into the different capsids.

The phage origin can also be engineered to act as a bacterial origin of replication without the need to package any phage particles.

A phage origin of replication comprised in the payload of the invention can be any origin of replication found in a phage.

Preferably, the phage origin of replication can be the wild-type or non-wildtype sequence of the M13, f1, φX174, P4, Lambda, P2, 186, Lambda-like, HK022, mEP237, HK97, HK629, HK630, mEP043, mEP213, mEP234, mEP390, mEP460, mEPx1, mEPx2, phi80, mEP234, T2, T4, T5, T7, RB49, phiX174, R17, PRD1 PI-like, P2-like, P22, P22-like, N15 and N15-like bacteriophages.

More preferably, the phage origin of replication is selected in the group consisting of phage origins of replication of M13, f1, φX174, P4, and Lambda.

In a particular embodiment, the phage origin of replication is the P4 origin of replication.

In a particular embodiment, the phage origin of replication is from Propionibacterium phages: BW-like phages such as Doucette, B22, E6, G4, BV-like phages such as Anatole, E1, B3, BX-like phages such as PFR1 and PFR2, filamentous B5 phage, BU-like phages (Cutibacterium acnes phages).

Conditional Origin of Replication

In a particular embodiment, the vector comprises a conditional origin of replication which is inactive in the targeted bacteria but is active in a donor bacterial cell.

In the context of the invention, a “conditional origin of replication” refers to an origin of replication whose functionality may be controlled by the presence of a specific molecule.

In a particular embodiment, the conditional origin of replication is an origin of replication, the replication of which depends upon the presence of one or more given protein, peptid, RNA, nucleic acid, molecule or any combination thereof.

In a particular embodiment, the replication of said origin of replication may further depend on a process, such as transcription, to activate said replication.

In the context of the invention, said conditional origin of replication is inactive in the targeted bacteria because of the absence of said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof in said targeted bacteria.

In a particular embodiment, said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof. In a particular embodiment, said protein, peptid, RNA nucleic acid, molecule or any combination thereof is expressed in trans in said donor bacterial cell.

By “in trans” is meant herein that said protein, peptid, RNA, nucleic acid, molecule or any combination thereof is not encoded on the same nucleic acid molecule as the one comprising the origin of replication. In a particular embodiment, said protein, peptid, RNA, nucleic acid, molecule or any combination thereof is encoded on a chromosome or on a vector, in particular a plasmid. In a particular embodiment, said vector comprises an antibiotic resistance marker. In an alternative embodiment, said vector is devoid of antibiotic resistance marker.

Since said conditional origin of replication is inactive in the targeted bacteria because of the absence of said given protein, peptid, RNA, nucleic acid, molecule or any combination thereof in said targeted bacteria, said conditional origin of replication may be selected depending on the specific bacteria to be targeted.

The conditional origin of replication disclosed herein may originate from plasmids, bacteriophages or PICIs which preferably share the following characteristics: they contain in their origin of replication repeat sequences, or iterons, and they code for at least one protein interacting with said origin of replication (i.e. Rep, protein O, protein P, pri) which is specific to them.

By way of example, mention may be made of the conditional replication systems of the following plasmids and bacteriophages: RK2, R1, pSC101, F, Rts1, RSF1010, P1, P4, lambda, phi82, phi80.

In a particular embodiment, said conditional origin of replication is selected from the group consisting of the R6KA DNA replication origin and derivatives thereof, the IncPα oriV origin of replication and derivatives thereof, ColE1 origins of replication modified to be under an inducible promoter, and origins of replication from phage-inducible chromosomal islands (PICIs) and derivatives thereof.

In a particular embodiment, said conditional origin of replication is an origin of replication present in less than 50%, or less than 40%, less than 30%, less than 20%, less than 10% or less than 5% of the bacteria of the host microbiome.

In another particular embodiment, said conditional origin of replication comprises or consists of a sequence less than 80% identical, in particular less than 70%, less than 60%, less than 50%, less than 40%, less than 30%, less than 20%, less than 10%, less than 5% or less than 1% identical to the sequences of the origins of replication of the bacteria of the host microbiome, in particular of the bacteria representing more than 50%, more particularly more than 60%, more than 70%, more than 80%, more than 90% or more than 95% of the host microbiome.

As used herein, the term “phage-inducible chromosomal islands” or “PICIs” refers to mobile genetic elements having a conserved gene organization, and encode a pair of divergent regulatory genes, including a PICI master repressor. Typically, in Gram-positive bacteria, left of rpr, and transcribed in the same direction, PICIs encode a small set of genes including an integrase (int) gene; right of rpr, and transcribed in the opposite direction, the PICIs encode an excision function (xis), and a replication module consisting of a primase homolog (pri) and optionally a replication initiator (rep), which are sometimes fused, followed by a replication origin (ori), next to these genes, and also transcribed in the same direction, PICIs encode genes involved in phage interference, and optionally, a terminase small subunit homolog (terS).

In a particular embodiment, said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs).

A particular conditional origin of replication has indeed been derived from PICIs.

It was shown that it is possible to derive novel conditionally replicative vectors, in particular based on the primase-helicase and origin of replication from PICIs. These origins may be relatively rare in target strains, and more advantageously the primase-ori pair may be unique for each PICI, significantly reducing the possibility of undesired recombination or payload spread events. They can further be modified to further limit recombination chances and remove restriction sites to bypass target bacteria defense systems.

In a particular embodiment, said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073, disclosed in Fillol-Salom et al. (2018) The ISME Journal 12:2114-2128.

In a particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, typically of sequence SEQ ID NO: 12.

In another particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, devoid of at least 1, at least 2, at least 3, at least 4, at least 5, at least 6, at least 7, at least 8, at least 9, at least 10, at least 11, at least 12, at least 13, at least 14, at least 15 or at least 16 restriction site(s) selected from the group consisting of GAAABCC, GCCGGC, RCCGGY, GCNGC, TWCANNNNNNTGG (SEQ ID NO: 13), TGGCCA, ACCYAC, YGGCCR, AGACC, GCWGC, GGGANGC, GKAGATD, GCCGGYYD, GGCYAC, RGCCGGYYD, and VGCCGGYBD.

In a particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073, devoid of the restriction site GAAABCC. Preferably, said conditional origin of replication is of sequence SEQ ID NO: 7.

In another particular embodiment, said conditional origin of replication is the primase ori from the PICI of the Escherichia coli strain CFT073 devoid of the restriction sites GAAABCC, GCCGGC, RCCGGY, GCNGC, TWCANNNNNNTGG (SEQ ID NO: 13), TGGCCA, ACCYAC, YGGCCR, AGACC, GCWGC, GGGANGC, GKAGATD, GCCGGYYD, GGCYAC, RGCCGGYYD, and VGCCGGYBD. Preferably, said conditional origin of replication is of sequence SEQ ID NO: 8.

In a particular embodiment, wherein said origin of replication is derived from phage-inducible chromosomal islands (PICIs), said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase, in particular a primase-helicase of sequence SEQ ID NO: 14, typically encoded by a nucleic acid comprising or consisting of the sequence SEQ ID NO: 15.

It was demonstrated that these specific conditional origins of replication were particularly compatible with lambda-based packaging, leading to sufficiently high titers (>10¹⁰/mL) required for microbiota-related applications.

In a particular embodiment, when said vector is a phagemid, said origin of replication may be derived from a microorganism which is different from the one that is used to encode the structural elements of the capsid packaging said phagemid.

By “donor bacterial cell” is meant herein a bacterium that is capable of hosting a vector as defined above, of producing a vector as defined above and/or which is capable of transferring said vector as defined above to another bacterium. In a particular embodiment, said vector may be a phagemid, and said donor bacterial cell may then be a bacterial cell able to produce said phagemid, more particularly in the form of a packaged phagemid. In an alternative embodiment, said vector may be a plasmid, more particularly a conjugative plasmid, and said donor bacterial cell may then be a bacterium that is capable of transferring said conjugative plasmid to another bacterium, in particular by conjugation.

Preferably, said donor bacterial cell stably comprises said vector and is able to replicate said vector.

In a particular embodiment, when the conditional origin of replication of said vector is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof, said donor bacterial cell expresses said protein, peptid, nucleic acid, RNA, molecule or any combination thereof. Preferably, said protein, peptid, nucleic acid, RNA, molecule or any combination thereof is expressed in trans, as defined above.

In a particular embodiment, said donor bacterial cell stably comprises a nucleic acid encoding said protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

In a particular embodiment, when said origin of replication is derived from phage-inducible chromosomal islands (PICIs), said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase, in particular a primase-helicase of sequence SEQ ID NO: 14.

In a particular embodiment, said donor bacterial cell stably comprises a nucleic acid encoding said rep protein, in particular said primase-helicase, said nucleic acid typically comprising or consisting of the sequence SEQ ID NO: 15.

In a particular embodiment, said donor bacterial cell is a production cell line, in particular a cell line producing packaged phagemids including the vector of the invention.

Generation of packaged phagemids and bacteriophage particles by production cell lines are routine techniques well-known to one skilled in the art. In an embodiment, a satellite phage and/or helper phage may be used to promote the packaging of the vector in the delivery vehicles disclosed herein. Helper phages provide functions in trans and are well known to the man skilled in the art. The helper phage comprises all the genes coding for the structural and functional proteins that are indispensable for the phagemid to be packaged, (i.e. the helper phage provides all the necessary gene products for the assembly of the delivery vehicle). The helper phage may contain a defective origin of replication or packaging signal, or completely lack the latter, and hence it is incapable of self-packaging, thus only bacterial delivery particles carrying the vector or plasmid will be produced. Helper phages may be chosen so that they cannot induce lysis of the bacterial cells used for the delivery particle production. One skilled in the art would understand that some bacteriophages are defective and need a helper phage for payload packaging. Thus, depending on the bacteriophage chosen to prepare the bacterial delivery particles, the person skilled in the art would know if a helper phage is required. Sequences coding for one or more proteins or regulatory processes necessary for the assembly or production of packaged payloads may be supplied in trans. For example, STF, gpJ and gpH proteins may be provided in a vector or plasmid under the control of an inducible promoter or expressed constitutively. In this case, the phage wild-type sequence may or not contain a deletion of the gene or sequence supplied in trans. Additionally, chimeric or modified phage sequences encoding a new function, like an engineered STF, gpJ or gpH protein, may be directly inserted into the desired position in the genome of the helper phage, hence bypassing the necessity of providing the modified sequence in trans. Methods for both supplying a sequence or protein in trans in the form of a vector or plasmid, as well as methods to generate direct genomic insertions, modifications and mutations are well known to those skilled in the art.

Delivery Vehicle Incapable of Self-Reproduction

In a particular embodiment, the delivery vehicle, in particular the bacteriophage, bacterial virus particle or packaged phagemid, comprising the vector of the invention is incapable of self-reproduction.

In the context of the present invention, “self-reproduction” is different from “self-replication”, “self-replication” referring to the capability of replicating a nucleic acid, whereas “self-reproduction” refers to the capability of having a progeny, in particular of producing new delivery vehicles, said delivery vehicles being either produced empty or with a nucleic acid of interest packaged.

By “delivery vehicle incapable of self-reproduction” is meant herein that at least one, several or all functional gene(s) necessary to produce said delivery vehicle is(are) absent from said delivery vehicle (and from said vector included in said delivery vehicle). In a preferred embodiment, said at least one, several or all functional gene(s) necessary to produce said delivery vehicle is(are) present in the donor cell as defined above, preferably in a plasmid, in the chromosome or in a helper phage present in the donor cell as defined above, enabling the production of said delivery vehicle in said donor cell.

In the context of the invention, said functional gene necessary to produce delivery vehicle may be absent through (i) the absence of the corresponding gene or (ii) the presence of the corresponding gene but in a non-functional form.

In an embodiment, the sequence of said gene necessary to produce said delivery vehicle is absent from said delivery vehicle. In a preferred embodiment, the sequence of said gene necessary to produce said delivery vehicle has been replaced by a nucleic acid sequence of interest, in particular by a nucleic acid sequence encoding enzymes or systems for inducing genetic modifications, as defined above.

Alternatively, said gene necessary to produce said delivery vehicle is present in said delivery vehicle in a non-functional form, for example in a mutant non-functional form, or in a non-expressible form, for example with deleted or mutated non-functional regulators. In a preferred embodiment, said gene necessary to produce said delivery vehicle is present in said delivery vehicle in a mutated form which renders it non-functional in the target cell, while remaining functional in the donor cell.

In the context of the invention, genes necessary to produce said delivery vehicle encompass any coding or non-coding nucleic acid required for the production of said delivery vehicle.

Examples of genes necessary to produce said delivery vehicle include genes encoding phage structural proteins; phage genes involved in the control of genetic expression; phage genes involved in transcription and/or translation regulation; phage genes involved in phage DNA replication; phage genes involved in production of phage proteins; phage genes involved in phage proteins folding; phage genes involved in phage DNA packaging; and phage genes encoding proteins involved in bacterial cell lysis.

Sequence of Interest Under the Control of the Promoter

The vector can comprise a sequence of interest under the control of at least one promoter.

In one embodiment, the sequence of interest is a programmable nuclease circuit to be delivered to the targeted bacteria. This programmable nuclease circuit may be able to mediate in vivo sequence-specific elimination of bacteria that contain a target gene of interest (e.g. a gene that is harmful to humans). Some embodiments of the present disclosure relate to engineered variants of the Type II CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR-associated) system of Streptococcus pyogenes. Other programmable nucleases that can be used include other CRISPR-Cas systems, engineered TALEN (Transcription Activator-Like Effector Nuclease) variants, engineered zinc finger nuclease (ZFN) variants, natural, evolved or engineered meganuclease or recombinase variants, and any combination or hybrids of programmable nucleases. Thus, the engineered autonomously distributed circuits provided herein may be used to selectively modify DNA encoding a gene of interest such as, for example, a toxin gene, a virulence factor gene, an antibiotic resistance gene, a remodeling gene or a modulatory gene (cf. WO2014124226 and US2015/0064138).

Other sequences of interest, preferably programmable, can be added to the vector so as to be delivered to targeted bacteria.

Preferably, the sequence of interest circuit added to the payload does not lead to bacteria death. For example, the sequence of interest may encode reporter genes leading to a luminescence or fluorescence signal. Alternatively, the sequence of interest may comprise proteins and enzymes achieving a useful function such as modifying the metabolism of the bacteria, the composition of its environment or affecting the host. More specifically the sequence of interest might be an antigen triggering a host immune response. The specific antigen can be released in the environment after induction of the lysis of the target cell or can be secreted by the target cell, for example, as described in Costa et al²² and Anné et al²³.

In a particular embodiment, the nucleic acid sequence of interest is selected from the group consisting of a Cas nuclease, a Cas9 nuclease, a guide RNA, a single guide RNA (sgRNA), a CRISPR locus, a gene expressing an enzyme such as a nuclease or a kinase, a TALEN, a ZFN, a meganuclease, a recombinase, a bacterial receptor, a membrane protein, a structural protein, a secreted protein, a gene expressing resistance to an antibiotic or to a drug in general, a gene expressing a toxic protein or a toxic factor and a gene expressing a virulence protein or a virulence factor, a bacterial secretory protein or transporter, a bacterial pore or any of their combination. These proteins can also be modified or engineered to include extra features, like the addition or removal of a function (e.g. dCas9), the addition of a secretion signal to a protein not normally secreted, the addition of an exogenous peptide in a loop as non-limiting examples.

Targeted Bacteria

The bacteria targeted by the vectors, delivery particles, bacteriophages, donor cells, bacterial virus particles or packaged phagemids can be any bacteria present in a mammal organism, a plant or in the environment. It can be any commensal, symbiotic or pathogenic bacteria of the microbiota or microbiome.

A microbiome may comprise a variety of endogenous bacterial species, any of which may be targeted in accordance with the present disclosure. In some embodiments, the genus and/or species of targeted endogenous bacterial cells may depend on the type of bacteriophages being used for preparing the bacterial virus particles. For example, some bacteriophages exhibit tropism for, or preferentially target, specific host species of bacteria. Other bacteriophages do not exhibit such tropism and may be used to target a number of different genus and/or species of endogenous bacterial cells.

Examples of bacterial cells include, without limitation, cells from bacteria of the genus Yersinia spp., Escherichia spp., Klebsiella spp., Acinetobacter spp., Bordetella spp., Neisseria spp., Aeromonas spp., Franciesella spp., Corynebacterium spp., Citrobacter spp., Chlamydia spp., Hemophilus spp., Brucella spp., Mycobacterium spp., Legionella spp., Rhodococcus spp., Pseudomonas spp., Helicobacter spp., Vibrio spp., Bacillus spp., Erysipelothrix spp., Salmonella spp., Streptomyces spp., Streptococcus spp., Staphylococcus spp., Bacteroides spp., Prevotella spp., Clostridium spp., Bifidobacterium spp., Clostridium spp., Brevibacterium spp., Lactococcus spp., Leuconostoc spp., Actinobacillus spp., Selnomonas spp., Shigella spp., Zymonas spp., Mycoplasma spp., Treponema spp., Leuconostoc spp., Corynebacterium spp., Enterococcus spp., Enterobacter spp., Pyrococcus spp., Serratia spp., Morganella spp., Parvimonas spp., Fusobacterium spp., Actinomyces spp., Porphyromonas spp., Micrococcus spp., Bartonella spp., Borrelia spp., Brucelia spp., Campylobacter spp., Chlamydophilia spp., Cutibacterium spp., Propionibacterium spp., Gardnerella spp., Ehrlichia spp., Haemophilus spp., Leptospira spp., Listeria spp., Mycoplasma spp., Nocardia spp., Rickettsia spp., Ureaplasma spp., Lactobacillus spp. and a mixture thereof.

Thus, vectors, delivery particles, bacteriophages, bacterial virus particles or packaged phagemids may target (e.g., specifically target) a bacterial cell from any one or more of the foregoing genus of bacteria to specifically deliver the payload according to the invention.

Preferably, the targeted bacteria can be selected from the group consisting of Yersinia spp., Escherichia spp., Klebsiella spp., Acinetobacter spp., Pseudomonas spp., Helicobacter spp., Vibrio spp, Salmonella spp., Streptococcus spp., Staphylococcus spp., Bacteroides spp., Clostridium spp., Shigella spp., Enterococcus spp., Enterobacter spp., Listeria spp., Cutibacterium spp., Propionibacterium spp., Fusobacterium spp., Porphyromonas spp. and Gardnerella spp.

In some embodiments, bacterial cells of the present invention are anaerobic bacterial cells (e.g., cells that do not require oxygen for growth). Anaerobic bacterial cells include facultative anaerobic cells such as but not limited to Escherichia coli, Shewanella oneidensi, Gardnerella vaginalis and Listeria. Anaerobic bacterial cells also include obligate anaerobic cells such as, for example, Bacteroides, Clostridium, Cutibacterium, Propionibacterium, Fusobacterium and Porphyromonas species. In humans, anaerobic bacteria are most commonly found in the gastrointestinal tract. In some particular embodiment, the targeted bacteria are thus bacteria most commonly found in the gastrointestinal tract. Bacteriophages used for preparing the bacterial virus particles, and then the bacterial virus particles, may target (e.g., to specifically target) anaerobic bacterial cells according to their specific spectra known by the person skilled in the art to specifically deliver the payload.

In some embodiments, the targeted bacterial cells are, without limitation, Bacteroides faecis, Bacteroides thetaiotaomicron, Bacteroides fragilis, Bacteroides distasonis, Bacteroides vulgatus, Clostridium leptum, Clostridium coccoides, Staphylococcus aureus, Bacillus subtilis, Clostridium butyricum, Brevibacterium lactofermentum, Streptococcus agalactiae, Lactococcus lactis, Leuconostoc lactis, Actinobacillus actinobycetemcomitans, cyanobacteria, Escherichia coli, Helicobacter pylori, Selnomonas ruminatium, Shigella sonnei, Zymomonas mobilis, Mycoplasma mycoides, Treponema denticola, Bacillus thuringiensis, Staphiococcus lugdunensis, Leuconostoc oenos, Corynebacterium xerosis, Lactobacillus plantarum, Lactobacillus rhamnosus, Lactobacillus casei, Lactobacillus acidophilus, Enterococcus faecalis, Bacillus coagulans, Bacillus cereus, Bacillus popillae, Synechocystis strain PCC6803, Bacillus liquefaciens, Pyrococcus abyssi, Selenomonas nominantium, Lactobacillus hilgardii, Streptococcus ferus, Lactobacillus pentosus, Bacteroides fragilis, Staphylococcus epidermidis, Streptomyces phaechromogenes, Streptomyces ghanaenis, Klebsiella pneumoniae, Enterobacter cloacae, Enterobacter aerogenes, Serratia marcescens, Morganella morganii, Citrobacter freundii, Propionibacterium freudenreichii, Pseudomonas aerigunosa, Parvimonas micra, Prevotella intermedia, Fusobacterium nucleatum, Prevotella nigrescens, Actinomyces israelii, Porphyromonas endodontalis, Porphyromonas gingivalis Micrococcus luteus, Bacillus megaterium, Aeromonas hydrophila, Aeromonas caviae, Bacillus anthracis, Bartonella henselae, Bartonella Quintana, Bordetella pertussis, Borrelia burgdorferi, Borrelia garinii, Borrelia afzelii, Borrelia recurrentis, Brucella abortus, Brucella canis, Brucella melitensis, Brucella suis, Campylobacter jejuni, Campylobacter coli, Campylobacter fetus, Chlamydia pneumoniae, Chlamydia trachomatis, Chlamydophila psittaci, Clostridium botulinum, Clostridium difficile, Clostridium perfringens, Clostridium tetani, Corynebacterium diphtheria, Cutibacterium acnes (formerly Propionibacterium acnes), Ehrlichia canis, Ehrlichia chaffeensis, Enterococcus faecium, Francisella tularensis, Haemophilus influenza, Legionella pneumophila, Leptospira interrogans, Leptospira santarosai, Leptospira weilii, Leptospira noguchii, Listeria monocytogenes, Mycobacterium leprae, Mycobacterium tuberculosis, Mycobacterium ulcerans, Mycoplasma pneumonia, Neisseria gonorrhoeae, Neisseria meningitides, Nocardia asteroids, Rickettsia rickettsia, Salmonella enteritidis, Salmonella typhi, Salmonella paratyphi, Salmonella typhimurium, Shigella flexnerii, Shigella dysenteriae, Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Gardnerella vaginalis, Streptococcus viridans, Treponema pallidum, Ureaplasma urealyticum, Vibrio cholera, Vibrio parahaemolyticus, Yersinia pestis, Yersinia enterocolitica, Yersinia pseudotuberculosis, Actinobacter baumanii, Pseudomonas aerigunosa, and a mixture thereof, preferably the bacteria of interest are selected from the group consisting of Escherichia coli, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa, Enterobacter cloacae, and Enterobacter aerogenes, and a mixture thereof.

In some embodiments, the targeted bacterial cells are, without limitation, Anaerotruncus, Acetanaerobacterium, Acetitomaculum, Acetivibrio, Anaerococcus, Anaerofilum, Anaerosinus, Anaerostipes, Anaerovorax, Butyrivibrio, Clostridium, Capracoccus, Dehalobacter, Dialister, Dorea, Enterococcus, Ethanoligenens, Faecalibacterium, Fusobacterium, Gracilibacter, Guggenheimella, Hespellia, Lachnobacterium, Lachnospira, Lactobacillus, Leuconostoc, Megamonas, Moryella, Mitsuokella, Oribacterium, Oxobacter, Papillibacter, Proprionispira, Pseudobutyrivibrio, Pseudoramibacter, Roseburia, Ruminococcus, Sarcina, Seinonella, Shuttleworthia, Sporobacter, Sporobacterium, Streptococcus, Subdoligranulum, Syntrophococcus, Thermobacillus, Turibacter, Weisella, Clostridium, Bacteroides, Ruminococcus, Faecalibacterium, Treponema, Phascolarctobacterium, Megasphaera, Faecalibacterium, Bifidobacterium, Lactobacillus, Sutterella, and/or Prevotella.

In other embodiments, the targeted bacteria cells are, without limitation, Achromobacter xylosoxidans, Acidaminococcus fermentans, Acidaminococcus intestini, Acidaminococcus sp., Acinetobacter baumannii, Acinetobacter junii, Acinetobacter Iwoffii, Actinobacillus capsulatus, Actinomyces naeslundii, Actinomyces neuii, Actinomyces odontolyticus, Actinomyces radingae, Adlercreutzia equolifaciens, Aeromicrobium massiliense, Aggregatibacter actinomycetemcomitans, Akkermansia muciniphila, Aliagarivorans marinus, Alistipes finegoldii, Alistipes indistinctus, Alistipes inops, Alistipes onderdonkii, Alistipes putredinis, Alistipes senegalensis, Alistipes shahii, Alistipes timonensis, Alloscardovia omnicolens, Anaerobacter polyendosporus, Anaerobaculum hydrogeniformans, Anaerococcus hydrogenalis, Anaerococcus prevotii, Anaerococcus senegalensis, Anaerofustis stercorihominis, Anaerostipes caccae, Anaerostipes hadrus, Anaerotruncus colihominis, Aneurinibacillus aneurinilyticus, Bacillus licheniformis, Bacillus massilioanorexius, Bacillus massiliosenegalensis, Bacillus simplex, Bacillus smithii, Bacillus subtilis, Bacillus thuringiensis, Bacillus timonensis, Bacteroides xylanisolvens, Bacteroides acidifaciens, Bacteroides caccae, Bacteroides capillosus, Bacteroides cellulosilyticus, Bacteroides clarus, Bacteroides coprocola, Bacteroides coprophilus, Bacteroides dorei, Bacteroides eggerthii, Bacteroides faecis, Bacteroides finegoldii, Bacteroides fluxus, Bacteroides fragilis, Bacteroides gallinarum, Bacteroides intestinalis, Bacteroides nordii, Bacteroides oleiciplenus, Bacteroides ovatus, Bacteroides pectinophilus, Bacteroides plebeius, Bacteroides salanitronis, Bacteroides salyersiae, Bacteroides sp., Bacteroides stercoris, Bacteroides thetaiotaomicron, Bacteroides uniformis, Bacteroides vulgatus, Bacteroides xylanisolvens, Bacteroidespectinophilus ATCC, Barnesiella intestinihominis, Bavariicoccus seileri, Bifidobacterium adolescentis, Bifidobacterium angulatum, Bifidobacterium animalis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium catenulatum, Bifidobacterium dentium, Bifidobacterium gallicum, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bifidobacterium stercoris, Bilophila wadsworthia, Blautia faecis, Blautia hansenii, Blautia hydrogenotrophica, Blautia luti, Blautia obeum, Blautia producta, Blautia wexlerae, Brachymonas chironomi, Brevibacterium senegalense, Bryantella formatexigens, butyrate-producing bacterium, Butyricicoccus pullicaecorum, Butyricimonas virosa, Butyrivibrio crossotus, Butyrivibrio fibrisolvens, Caldicoprobacter faecalis, Campylobacter concisus, Campylobacter jejuni, Campylobacter upsaliensis, Catenibacterium mitsuokai, Cedecea davisae, Cellulomonas massiliensis, Cetobacterium somerae, Citrobacter braakii, Citrobacter freundii, Citrobacter pasteurii, Citrobacter sp., Citrobacter youngae, Cloacibacillus evryensis, Clostridiales bacterium, Clostridioides difficile, Clostridium asparagiforme, Clostridium bartlettii, Clostridium boliviensis, Clostridium bolteae, Clostridium hathewayi, Clostridium hiranonis, Clostridium hylemonae, Clostridium leptum, Clostridium methylpentosum, Clostridium nexile, Clostridium orbiscindens, Clostridium ramosum, Clostridium scindens, Clostridium sp, Clostridium sp., Clostridium spiroforme, Clostridium sporogenes, Clostridium symbiosum, Collinsella aerofaciens, Collinsella intestinalis, Collinsella stercoris, Collinsella tanakaei, Coprobacillus cateniformis, Coprobacter fastidiosus, Coprococcus catus, Coprococcus comes, Coprococcus eutactus, Corynebacterium ammoniagenes, Corynebacterium amycolatum, Corynebacterium pseudodiphtheriticum, Cutibacterium acnes, Dermabacter hominis, Desulfitobacterium hafniense, Desulfovibrio fairfieldensis, Desulfovibrio piger, Dialister succinatiphilus, Dielma fastidiosa, Dorea formicigenerans, Dorea longicatena, Dysgonomonas capnocytophagoides, Dysgonomonas gadei, Dysgonomonas mossii, Edwardsiella tarda, Eggerthella lenta, Eisenbergiella tayi, Enorma massiliensis, Enterobacter aerogenes, Enterobacter asburiae, Enterobacter cancerogenus, Enterobacter cloacae, Enterobacter massiliensis, Enterococcus casseliflavus, Enterococcus durans, Enterococcus faecalis, Enterococcus faecium, Enterococcus flavescens, Enterococcus gallinarum, Enterococcus sp., Enterovibrio nigricans, Erysipelatoclostridium ramosum, Escherichia coli, Escherichia sp., Eubacterium biforme, Eubacterium dolichum, Eubacterium hallii, Eubacterium limosum, Eubacterium ramulus, Eubacterium rectale, Eubacterium siraeum, Eubacterium ventriosum, Exiguobacterium marinum, Exiguobacterium undae, Faecalibacterium cf, Faecalibacterium prausnitzii, Faecalitalea cylindroides, Ferrimonas balearica, Finegoldia magna, Flavobacterium daejeonense, Flavonifractor plautii, Fusicatenibacter saccharivorans, Fusobacterium gonidiaformans, Fusobacterium mortiferum, Fusobacterium necrophorum, Fusobacterium nucleatum, Fusobacterium periodonticum, Fusobacterium sp., Fusobacterium ulcerans, Fusobacterium varium, Gallibacterium anatis, Gemmiger formicilis, Gordonibacter pamelaeae, Hafnia alvei, Helicobacter bilis, Helicobacter bills, Helicobacter canadensis, Helicobacter canis, Helicobacter cinaedi, Helicobacter macacae, Helicobacter pametensis, Helicobacter pullorum, Helicobacter pylori, Helicobacter rodentium, Helicobacter winghamensis, Herbaspirillum massiliense, Holdemanella biformis, Holdemania fdiformis, Holdemania filiformis, Holdemania massiliensis, Holdemaniafiliformis, Hungatella hathewayi, Intestinibacter bartlettii, Intestinimonas butyriciproducens, Klebsiella oxytoca, Klebsiella pneumoniae, Kurthia massiliensis, Lachnospira pectinoschiza, Lactobacillus acidophilus, Lactobacillus amylolyticus, Lactobacillus animalis, Lactobacillus antri, Lactobacillus brevis, Lactobacillus buchneri, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus iners, Lactobacillus intestinalis, Lactobacillus johnsonii, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus ruminis, Lactobacillus sakei, Lactobacillus salivarius, Lactobacillus ultunensis, Lactobacillus vaginalis, Lactobacillus plantarum subsp., Leuconostoc mesenteroides, Leuconostoc pseudomesenteroides, Listeria grayi, Listeria innocua, Mannheimia granulomatis, Marvinbryantia formatexigens, Megamonas funiformis, Megamonas hypermegale, Methanobrevibacter smithii, Methanobrevibacter smithii FI, Micrococcus luteus, Microvirgula aerodenitrificans, Mitsuokella jalaludinii, Mitsuokella multacida, Mollicutes bacterium, Murimonas intestini, Neisseria macacae, Nitriliruptor alkaliphilus, Oceanobacillus massiliensis, Odoribacter laneus, Odoribacter splanchnicus, Ornithobacterium rhinotracheale, Oxalobacter formigenes, Paenibacillus barengoltzii, Paenibacillus chitinolyticus, Paenibacillus lautus, Paenibacillus motobuensis, Paenibacillus senegalensis, Paenisporosarcina quisquiliarum, Parabacteroides distasonis, Parabacteroides goldsteinii, Parabacteroides gordonii, Parabacteroides johnsonii, Parabacteroides merdae, Paraprevotella xylaniphila, Parasutterella excrementihominis, Parvimonas micra, Pediococcus acidilactici, Peptoclostridium difficile, Peptoniphilus harei, Peptoniphilus obesi, Peptoniphilus senegalensis, Peptoniphilus timonensis, Phascolarctobacterium succinatutens, Porphyromonas asaccharolytica, Porphyromonas uenonis, Prevotella baroniae, Prevotella bivia, Prevotella copri, Prevotella dentalis, Prevotella micans, Prevotella multisaccharivorax, Prevotella oralis, Prevotella salivae, Prevotella stercorea, Prevotella veroralis, Propionibacterium acnes, Propionibacterium avidum, Propionibacterium freudenreichii, Propionimicrobium lymphophilum, Proteus mirabilis, Proteuspenneri ATCC, Providencia alcalifaciens, Providencia rettgeri, Providencia rustigianii, Providencia stuartii, Pseudoflavonifractor capillosus, Pseudomonas aeruginosa, Pseudomonas luteola, Ralstonia pickettii, Rheinheimera perlucida, Rheinheimera texasensis, Riemerella columbina, Romboutsia lituseburensis, Roseburia faecis, Roseburia intestinalis, Roseburia inulinivorans, Ruminococcus bicirculans, Ruminococcus bromii, Ruminococcus callidus, Ruminococcus champanellensis, Ruminococcus faecis, Ruminococcus gnavus, Ruminococcus lactaris, Ruminococcus obeum, Ruminococcus sp, Ruminococcus sp., Ruminococcus torques, Sarcina ventriculi, Sellimonas intestinalis, Senegalimassilia anaerobia, Shigella sonnei, Slackia piriformis, Staphylococcus epidermidis, Staphylococcus lentus, Staphylococcus nepalensis, Staphylococcus pseudintermedius, Staphylococcus xylosus, Stenotrophomonas maltophilia, Streptococcus agalactiae, Streptococcus anginosus, Streptococcus australis, Streptococcus caballi, Streptococcus castoreus, Streptococcus didelphis, Streptococcus equinus, Streptococcus gordonii, Streptococcus henryi, Streptococcus hyovaginalis, Streptococcus infantarius, Streptococcus infantis, Streptococcus lutetiensis, Streptococcus merionis, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus ovis, Streptococcus parasanguinis, Streptococcus plurextorum, Streptococcus porci, Streptococcus pyogenes, Streptococcus salivarius, Streptococcus sobrinus, Streptococcus thermophilus, Streptococcus thoraltensis, Streptomyces albus, Subdoligranulum variabile, Succinatimonas hippei, Sutterella parvirubra, Sutterella wadsworthensis, Terrisporobacter glycolicus, Terrisporobacter mayombei, Thalassobacillus devorans, Timonella senegalensis, Turicibacter sanguinis, unknown sp, unknown sp., Varibaculum cambriense, Veillonella atypica, Veillonella dispar, Veillonella parvula, Vibrio cincinnatiensis, Virgibacillus salexigens, and Weissella paramesenteroides. In other embodiments, the targeted bacteria cells are those commonly found on the skin microbiota and are without limitation Acetobacter farinalis, Acetobacter malorum, Acetobacter orleanensis, Acetobacter sicerae, Achromobacter anxifer, Achromobacter denitrificans, Achromobacter marplatensis, Achromobacter spanius, Achromobacter xylosoxidans subsp. xylosoxidans, Acidovorax konjaci, Acidovorax radicis, Acinetobacter johnsonii, Actinomadura citrea, Actinomadura coerulea, Actinomadura fibrosa, Actinomadura fulvescens, Actinomadura jiaoheensis, Actinomadura luteofluorescens, Actinomadura mexicana, Actinomadura nitritigenes, Actinomadura verrucosospora, Actinomadura yumaensis, Actinomyces odontolyticus, Actinomycetospora atypica, Actinomycetospora corticicola, Actinomycetospora rhizophila, Actinomycetospora rishiriensis, Aeromonas australiensis, Aeromonas bestiarum, Aeromonas bivalvium, Aeromonas encheleia, Aeromonas eucrenophila, Aeromonas hydrophila subsp. hydrophila, Aeromonas piscicola, Aeromonas popoffii, Aeromonas rivuli, Aeromonas salmonicida subsp. pectinolytica, Aeromonas salmonicida subsp. smithia, Amaricoccus kaplicensis, Amaricoccus veronensis, Aminobacter aganoensis, Aminobacter ciceronei, Aminobacter lissarensis, Aminobacter niigataensis, Ancylobacter polymorphus, Anoxybacillus flavithermus subsp. yunnanensis, Aquamicrobium aerolatum, Archangium gephyra, Archangium gephyra, Archangium minus, Archangium violaceum, Arthrobacter viscosus, Bacillus anthracis, Bacillus australimaris, Bacillus drentensis, Bacillus mycoides, Bacillus pseudomycoides, Bacillus pumilus, Bacillus safensis, Bacillus vallismortis, Bosea thiooxidans, Bradyrhizobium huanghuaihaiense, Bradyrhizobium japonicum, Brevundimonas aurantiaca, Brevundimonas intermedia, Burkholderia aspalathi, Burkholderia choica, Burkholderia cordobensis, Burkholderia diffusa, Burkholderia insulsa, Burkholderia rhynchosiae, Burkholderia terrestris, Burkholderia udeis, Buttiauxella gaviniae, Caenimonas terrae, Capnocytophaga gingivalis, Chitinophaga dinghuensis, Chryseobacterium gleum, Chryseobacterium greenlandense, Chryseobacterium jejuense, Chryseobacterium piscium, Chryseobacterium sediminis, Chryseobacterium tructae, Chryseobacterium ureilyticum, Chryseobacterium vietnamense, Corynebacterium accolens, Corynebacterium afermentans subsp. lipophilum, Corynebacterium minutissimum, Corynebacterium sundsvallense, Cupriavidus metallidurans, Cupriavidus nantongensis, Cupriavidus necator, Cupriavidus pampae, Cupriavidus yeoncheonensis, Curtobacterium flaccumfaciens, Devosia epidermidihirudinis, Devosia riboflavina, Devosia riboflavina, Diaphorobacter oryzae, Dietzia psychralcaliphila, Ensifer adhaerens, Ensifer americanus, Enterococcus malodoratus, Enterococcus pseudoavium, Enterococcus viikkiensis, Enterococcus xiangfangensis, Erwinia rhapontici, Falsirhodobacter halotolerans, Flavobacterium araucananum, Flavobacterium frigidimaris, Gluconobacter frateurii, Gluconobacter thailandicus, Gordonia alkanivorans, Halomonas aquamarina, Halomonas axialensis, Halomonas meridiana, Halomonas olivaria, Halomonas songnenensis, Halomonas variabilis, Herbaspirillum chlorophenolicum, Herbaspirillum frisingense, Herbaspirillum hiltneri, Herbaspirillum huttiense subsp. putei, Herbaspirillum lusitanum, Herminiimonas fonticola, Hydrogenophaga intermedia, Hydrogenophaga pseudoflava, Klebsiella oxytoca, Kosakonia sacchari, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus modestisalitolerans, Lactobacillus plantarum subsp. argentoratensis, Lactobacillus xiangfangensis, Lechevalieria roselyniae, Lentzea albida, Lentzea califomiensis, Leuconostoc carnosum, Leuconostoc citreum, Leuconostoc gelidum subsp. gasicomitatum, Leuconostoc mesenteroides subsp. suionicum, Luteimonas aestuarii, Lysobacter antibioticus, Lysobacter koreensis, Lysobacter oryzae, Magnetospirillum moscoviense, Marinomonas alcarazii, Marinomonas primoryensis, Massilia aurea, Massilia jejuensis, Massilia kyonggiensis, Massilia timonae, Mesorhizobium acaciae, Mesorhizobium qingshengii, Mesorhizobium shonense, Methylobacterium haplocladii, Methylobacterium platani, Methylobacterium pseudosasicola, Methylobacterium zatmanii, Microbacterium oxydan, Micromonospora chaiyaphumensis, Micromonospora chalcea, Micromonospora citrea, Micromonospora coxensis, Micromonospora echinofusca, Micromonospora halophytica, Micromonospora kangleipakensis, Micromonospora maritima, Micromonospora nigra, Micromonospora purpureochromogene, Micromonospora rhizosphaerae, Micromonospora saelicesensis, Micro virga subterranea, Microvirga zambiensis, Mycobacterium alvei, Mycobacterium avium subsp. silvaticum, Mycobacterium colombiense, Mycobacterium conceptionense, Mycobacterium conceptionense, Mycobacterium farcinogenes, Mycobacterium fortuitum subsp. fortuitum, Mycobacterium goodii, Mycobacterium insubricum, Mycobacterium Ilatzerense, Mycobacterium neoaurum, Mycobacterium neworleansense, Mycobacterium obuense, Mycobacterium peregrinum, Mycobacterium saopaulense, Mycobacterium septicum, Mycobacterium setense, Mycobacterium smegmatis, Neisseria subflava, Nocardia lijiangensis, Nocardia thailandica, Novosphingobium barchaimii, Novosphingobium lindaniclasticum, Novosphingobium lindaniclasticum, Novosphingobium mathurense, Ochrobactrum pseudogrignonense, Oxalicibacterium solurbis, Paraburkholderia glathei, Paraburkholderia humi, Paraburkholderia phenazinium, Paraburkholderia phytofirmans, Paraburkholderia sordidicola, Paraburkholderia terricola, Paraburkholderia xenovorans, Paracoccus laeviglucosivorans, Patulibacter ginsengiterrae, Polymorphospora rubra, Porphyrobacter colymbi, Prevotella jejuni, Prevotella melaninogenica, Propionibacterium acnes subsp. elongatum, Proteus vulgaris, Providencia rustigianii, Pseudoalteromonas agarivorans, Pseudoalteromonas atlantica, Pseudoalteromonas paragorgicola, Pseudomonas asplenii, Pseudomonas asuensis, Pseudomonas benzenivorans, Pseudomonas cannabina, Pseudomonas cissicola, Pseudomonas congelans, Pseudomonas costantinii, Pseudomonas ficuserectae, Pseudomonas frederiksbergensis, Pseudomonas graminis, Pseudomonas jessenii, Pseudomonas koreensis, Pseudomonas koreensis, Pseudomonas kunmingensis, Pseudomonas marginalis, Pseudomonas mucidolens, Pseudomonas panacis, Pseudomonas plecoglossicida, Pseudomonas poae, Pseudomonas pseudoalcaligenes, Pseudomonas putida, Pseudomonas reinekei, Pseudomonas rhizosphaerae, Pseudomonas seleniipraecipitans, Pseudomonas umsongensis, Pseudomonas zhaodongensis, Pseudonocardia alaniniphila, Pseudonocardia ammonioxydans, Pseudonocardia autotrophica, Pseudonocardia kongjuensis, Pseudonocardia yunnanensis, Pseudorhodoferax soli, Pseudoxanthomonas daejeonensis, Pseudoxanthomonas indica, Pseudoxanthomonas kaohsiungensis, Psychrobacter aquaticus, Psychrobacter arcticus, Psychrobacter celer, Psychrobacter marincola, Psychrobacter nivimaris, Psychrobacter okhotskensis, Psychrobacter okhotskensis, Psychrobacter piscatorii, Psychrobacter pulmonis, Ramlibacter ginsenosidimutans, Rheinheimera japonica, Rheinheimera muenzenbergensis, Rheinheimera soli, Rheinheimera tangshanensis, Rheinheimera texasensis, Rheinheimera tilapiae, Rhizobium alamii, Rhizobium azibense, Rhizobium binae, Rhizobium daejeonense, Rhizobium endophyticum, Rhizobium etli, Rhizobium fabae, Rhizobium freirei, Rhizobium gallicum, Rhizobium loessense, Rhizobium sophoriradicis, Rhizobium taibaishanense, Rhizobium vallis, Rhizobium vignae, Rhizobium vignae, Rhizobium yanglingense, Rhodococcus baikonurensis, Rhodococcus enclensis, Rhodoferax saidenbachensis, Rickettsia canadensis, Rickettsia heilongjiangensis, Rickettsia honei, Rickettsia raoultii, Roseateles aquatilis, Roseateles aquatilis, Salmonella enterica subsp. salamae, Serratia ficaria, Serratia myotis, Serratia vespertilionis, Shewanella aestuarii, Shewanella decolorationis, Sphingobium amiense, Sphingobium baderi, Sphingobium barthaii, Sphingobium chlorophenolicum, Sphingobium cupriresistens, Sphingobium czechense, Sphingobium fuliginis, Sphingobium indicum, Sphingobium indicum, Sphingobium japonicum, Sphingobium lactosutens, Sphingomonas dokdonensis, Sphingomonas pseudosanguinis, Sphingopyxis chilensis, Sphingopyxis fribergensis, Sphingopyxis granuli, Sphingopyxis indica, Sphingopyxis witflariensis, Staphylococcus agnetis, Staphylococcus aureus subsp. aureus, Staphylococcus epidermidis, Staphylococcus hominis subsp. novobiosepticus, Staphylococcus nepalensis, Staphylococcus saprophyticus subsp. bovis, Staphylococcus sciuri subsp. carnaticus, Streptomyces caeruleatus, Streptomyces canarius, Streptomyces capoamus, Streptomyces ciscaucasicus, Streptomyces griseorubiginosus, Streptomyces olivaceoviridis, Streptomyces panaciradicis, Streptomyces phaeopurpureus, Streptomyces pseudovenezuelae, Streptomyces resistomycificus, Tianweitania sediminis, Tsukamurella paurometabola, Variovorax guangxiensis, Vogesella alkaliphila, Xanthomonas arboricola, Xanthomonas axonopodis, Xanthomonas cassavae, Xanthomonas cucurbitae, Xanthomonas cynarae, Xanthomonas euvesicatoria, Xanthomonas fragariae, Xanthomonas gardneri, Xanthomonas perforans, Xanthomonas pisi, Xanthomonas populi, Xanthomonas vasicola, Xenophilus aerolatus, Yersinia nurmii, Abiotrophia defectiva, Acidocella aminolytica, Acinetobacter guangdongensis, Acinetobacter parvus, Acinetobacter radioresistens, Acinetobacter soli, Acinetobacter variabilis, Actinomyces cardiffensis, Actinomyces dentalis, Actinomyces europaeus, Actinomyces gerencseriae, Actinomyces graevenitzii, Actinomyces haliotis, Actinomyces johnsonii, Actinomyces massiliensis, Actinomyces meyeri, Actinomyces meyeri, Actinomyces naeslundii, Actinomyces neuii subsp. anitratus, Actinomyces odontolyticus, Actinomyces oris, Actinomyces turicensis, Actinomycetospora corticicola, Actinotignum schaalii, Aerococcus christensenii, Aerococcus urinae, Aeromicrobium flavum, Aeromicrobium massiliense, Aeromicrobium tamlense, Aeromonas sharmana, Aggregatibacter aphrophilus, Aggregatibactersegnis, Agrococcus baldri, Albibacter methylovorans, Alcaligenes faecalis subsp. faecalis, Algoriphagus ratkowskyi, Alkalibacterium olivapovliticus, Alkalibacterium pelagium, Alkalibacterium pelagium, Alloprevotella rava, Alsobacter metallidurans, Amaricoccus kaplicensis, Amaricoccus veronensis, Anaerococcus hydrogenalis, Anaerococcus lactolyticus, Anaerococcus murdochii, Anaerococcus octavius, Anaerococcus prevotii, Anaerococcus vaginalis, Aquabacterium citratiphilum, Aquabacterium olei, Aquabacterium olei, Aquabacterium parvum, Aquincola tertiaricarbonis, Arcobacter venerupis, Arsenicicoccus bolidensis, Arthrobacter russicus, Asticcacaulis excentricus, Atopobium deltae, Atopobium parvulum, Atopobium rimae, Atopobium vaginae, Aureimonas altamirensis, Aureimonas rubiginis, Azospira oryzae, Azospirillum oryzae, Bacillus circulans, Bacillus drentensis, Bacillus fastidiosus, Bacillus lehensis, Bacillus oceanisediminis, Bacillus rhizosphaerae, Bacteriovorax stolpii, Bacteroides coagulans, Bacteroides dorei, Bacteroides fragilis, Bacteroides ovatus, Bacteroides stercoris, Bacteroides uniformis, Bacteroides vulgatus, Bdellovibrio bacteriovorus, Bdellovibrio exovorus, Belnapia moabensis, Belnapia soli, Blautia hansenii, Blautia obeum, Blautia wexlerae, Bosea lathyri, Brachybacterium fresconis, Brachybacterium muris, Brevibacterium ammoniilyticum, Brevibacterium casei, Brevibacterium epidermidis, Brevibacterium iodinum, Brevibacterium luteolum, Brevibacterium paucivorans, Brevibacterium pityocampae, Brevibacterium sanguinis, Brevundimonas albigilva, Brevundimonas diminuta, Brevundimonas vancanneytii, Caenimonas terrae, Calidifontibacter indicus, Campylobacter concisus, Campylobacter gracilis, Campylobacter hominis, Campylobacter rectus, Campylobacter showae, Campylobacter ureolyticus, Capnocytophaga gingivalis, Capnocytophaga leadbetteri, Capnocytophaga ochracea, Capnocytophaga sputigena, Cardiobacterium hominis, Cardiobacterium valvarum, Carnobacterium divergens, Catonella morbi, Caulobacter henricii, Cavicella subterranea, Cellulomonas xylanilyfica, Cellvibrio vulgaris, Chitinimonas taiwanensis, Chryseobacterium arachidis, Chryseobacterium daecheongense, Chryseobacterium formosense, Chryseobacterium formosense, Chryseobacterium greenlandense, Chryseobacterium indologenes, Chryseobacterium piscium, Chryseobacterium rigui, Chryseobacterium solani, Chryseobacterium taklimakanense, Chryseobacterium ureilyticum, Chryseobacterium ureilyticum, Chryseobacterium zeae, Chryseomicrobium aureum, Cloacibacterium haliotis, Cloacibacterium normanense, Cloacibacterium normanense, Collinsella aerofaciens, Comamonas denitrificans, Comamonas terrigena, Corynebacterium accolens, Corynebacterium afermentans subsp. lipophilum, Corynebacterium ammoniagenes, Corynebacterium amycolatum, Corynebacterium aurimucosum, Corynebacterium aurimucosum, Corynebacterium coyleae, Corynebacterium durum, Corynebacterium freiburgense, Corynebacterium glaucum, Corynebacterium glyciniphilum, Corynebacterium imitans, Corynebacterium jeikeium, Corynebacterium jeikeium, Corynebacterium kroppenstedtii, Corynebacterium lipophiloflavum, Corynebacterium massiliense, Corynebacterium mastitidis, Corynebacterium matruchotii, Corynebacterium minutissimum, Corynebacterium mucifaciens, Corynebacterium mustelae, Corynebacterium mycetoides, Corynebacterium pyruviciproducens, Corynebacterium simulans, Corynebacterium singulare, Corynebacterium sputi, Corynebacterium suicordis, Corynebacterium tuberculostearicum, Corynebacterium tuberculostearicum, Corynebacterium ureicelerivorans, Corynebacterium variabile, Couchioplanes caeruleus subsp. caeruleus, Cupriavidus metallidurans, Curtobacterium herbarum, Dechloromonas agitata, Deinococcus actinosclerus, Deinococcus antarcticus, Deinococcus caeni, Deinococcus ficus, Deinococcus geothermalis, Deinococcus radiodurans, Deinococcus wulumuqiensis, Deinococcus xinjiangensis, Dermabacter hominis, Dermabacter vaginalis, Dermacoccus nishinomiyaensis, Desemzia incerta, Desertibacter roseus, Dialister invisus, Dialister micraerophilus, Dialister propionicifaciens, Dietzia aurantiaca, Dietzia cercidiphylli, Dietzia timorensis, Dietzia timorensis, Dokdonella koreensis, Dokdonella koreensis, Dolosigranulum pigrum, Eikenella corrodens, Elizabethkingia miricola, Elstera litoralis, Empedobacter brevis, Enhydrobacter aerosaccus, Enterobacter xiangfangensis, Enterococcus aquimarinus, Enterococcus faecalis, Enterococcus olivae, Erwinia rhapontici, Eubacterium eligens, Eubacterium infirmum, Eubacterium rectale, Eubacterium saphenum, Eubacterium sulci, Exiguobacterium mexicanum, Facklamia tabacinasalis, Falsirhodobacter halotolerans, Finegoldia magna, Flavobacterium cutihirudinis, Flavobacterium lindanitolerans, Flavobacterium resistens, Friedmanniella capsulata, Fusobacterium nucleatum subsp. polymorphum, Gemella haemolysans, Gemella morbillorum, Gemella palaticanis, Gemella sanguinis, Gemmobacter aquaticus, Gemmobacter caeni, Gordonia jinhuaensis, Gordonia kroppenstedtii, Gordonia polyisoprenivorans, Gordonia polyisoprenivorans, Granulicatella adiacens, Granulicatella elegans, Haemophilus parainfluenzae, Haemophilus sputorum, Halomonas suffidaeris, Herpetosiphon aurantiacus, Hydrocarboniphaga effusa, ldiomarina marls, Janibacter anophelis, Janibacter hoylei, Janibacter indicus, Janibacter limosus, Janibacter melonis, Jeotgalicoccus halophilus, Jonquetella anthropi, Kaistia geumhonensis, Kingella denitrificans, Kingella oralis, Klebsiella oxytoca, Knoellia aerolata, Knoellia locipacati, Kocuria atrinae, Kocuria camiphila, Kocuria kristinae, Kocuria palustris, Kocuria turfanensis, Lachnoanaerobaculum saburreum, Lachnoanaerobaculum saburreum, Lactobacillus crispatus, Lactobacillus iners, Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. lactis, Lactococcus piscium, Lapillicoccus jejuensis, Lautropia mirabilis, Legionella beliardensis, Leptotrichia buccalis, Leptotrichia goodfellowii, Leptotrichia hofstadii, Leptotrichia hongkongensis, Leptotrichia shahii, Leptotrichia trevisanii, Leptotrichia wadei, Luteimonas terricola, Lysinibacillus fusiformis, Lysobacter spongiicola, Lysobacter xinjiangensis, Macrococcus caseolyticus, Marmoricola pocheonensis, Marmoricola scoriae, Massilia alkalitolerans, Massilia alkalitolerans, Massilia aurea, Massilia plicata, Massilia timonae, Megamonas rupellensis, Meiothermus silvanus, Methylobacterium dankookense, Methylobacterium goesingense, Methylobacterium goesingense, Methylobacterium isbiliense, Methylobacterium jeotgali, Methylobacterium oxalidis, Methylobacterium platani, Methylobacterium pseudosasicola, Methyloversatilis universalis, Microbacterium foliorum, Microbacterium hydrothermale, Microbacterium hydrothermale, Microbacterium lacticum, Microbacterium lacticum, Microbacterium laevaniformans, Microbacterium paludicola, Microbacterium petrolearium, Microbacterium phyllosphaerae, Microbacterium resistens, Micrococcus antarcticus, Micrococcus cohnii, Micrococcus flavus, Micrococcus lylae, Micrococcus terreus, Microlunatus aurantiacus, Micropruina glycogenica, Microvirga aerilata, Microvirga aerilata, Microvirga subterranea, Microvirga vignae, Microvirga zambiensis, Microvirgula aerodenitrificans, Mogibacterium timidum, Moraxella atlantae, Moraxella catarrhalis, Morganella morganii subsp. morganii, Morganella psychrotolerans, Murdochiella asaccharolytica, Mycobacterium asiaticum, Mycobacterium chubuense, Mycobacterium crocinum, Mycobacterium gadium, Mycobacterium holsaticum, Mycobacterium iranicum, Mycobacterium longobardum, Mycobacterium neoaurum, Mycobacterium neoaurum, Mycobacterium obuense, Negativicoccus succinicivorans, Neisseria bacilliformis, Neisseria oralis, Neisseria sicca, Neisseria subflava, Nesterenkonia lacusekhoensis, Nesterenkonia rhizosphaerae, Nevskia persephonica, Nevskia ramosa, Niabella yanshanensis, Niveibacterium umoris, Nocardia niwae, Nocardia thailandica, Nocardioides agariphilus, Nocardioides dilutus, Nocardioides ganghwensis, Nocardioides hwasunensis, Nocardioides nanhaiensis, Nocardioides sediminis, Nosocomiicoccus ampullae, Noviherbaspirillum malthae, Novosphingobium lindaniclasticum, Novosphingobium rosa, Ochrobactrum rhizosphaerae, Olsenella uli, Ornithinimicrobium murale, Ornithinimicrobium tianjinense, Oryzobacterterrae, Ottowia beijingensis, Paenalcaligenes suwonensis, Paenibacillus agaridevorans, Paenibacillus phoenicis, Paenibacillus xylanexedens, Paludibacterium yongneupense, Pantoea cypripedii, Parabacteroides distasonis, Paraburkholderia andropogonis, Paracoccus alcaliphilus, Paracoccus angustae, Paracoccus kocurii, Paracoccus laeviglucosivorans, Paracoccus sediminis, Paracoccus sphaerophysae, Paracoccus yeei, Parvimonas micra, Parviterribacter multiflagellatus, Patulibacter ginsengiterrae, Pedobacter aquatilis, Pedobacter ginsengisoli, Pedobacter xixiisoli, Peptococcus niger, Peptoniphilus coxii, Peptoniphilus gorbachii, Peptoniphilus harei, Peptoniphilus koenoeneniae, Peptoniphilus lacrimalis, Peptostreptococcus anaerobius, Peptostreptococcus stomatis, Phascolarctobacterium faecium, Phenylobacterium haematophilum, Phenylobacterium kunshanense, Pluralibacter gergoviae, Polymorphobacter multimanifer, Porphyromonas bennonis, Porphyromonas endodontalis, Porphyromonas gingivalis, Porphyromonas gingivicanis, Porphyromonas pasteri, Porphyromonas pogonae, Porphyromonas somerae, Povalibacter uvarum, Prevotella aurantiaca, Prevotella baroniae, Prevotella bivia, Prevotella buccae, Prevotella buccalis, Prevotella copri, Prevotella corporis, Prevotella denticola, Prevotella enoeca, Prevotella histicola, Prevotella intermedia, Prevotella jejuni, Prevotella jejuni, Prevotella maculosa, Prevotella melaninogenica, Prevotella melaninogenica, Prevotella micans, Prevotella multiformis, Prevotella nanceiensis, Prevotella nigrescens, Prevotella oris, Prevotella oulorum, Prevotella pallens, Prevotella pleuritidis, Prevotella saccharolytica, Prevotella salivae, Prevotella shahii, Prevotella timonensis, Prevotella veroralis, Propionibacterium acidifaciens, Propionibacterium acnes subsp. acnes, Propionibacterium acnes subsp. acnes, Propionibacterium acnes subsp. elongatum, Propionibacterium granulosum, Propionimicrobium lymphophilum, Propionispira arcuata, Pseudokineococcus lusitanus, Pseudomonas aeruginosa, Pseudomonas chengduensis, Pseudonocardia benzenivorans, Pseudorhodoplanes sinuspersici, Psychrobacter sanguinis, Ramlibacter ginsenosidimutans, Rheinheimera aquimaris, Rhizobium alvei, Rhizobium daejeonense, Rhizobium larrymoorei, Rhizobium rhizoryzae, Rhizobium soli, Rhizobium taibaishanense, Rhizobium vignae, Rhodanobacter glycinis, Rhodobacter veldkampii, Rhodococcus enclensis, Rhodococcus fascians, Rhodococcus fascians, Rhodovarius lipocyclicus, Rivicola pingtungensis, Roseburia inulinivorans, Rosenbergiella nectarea, Roseomonas aerilata, Roseomonas aquatica, Roseomonas mucosa, Roseomonas rosea, Roseomonas vinacea, Rothia aeria, Rothia amarae, Rothia dentocariosa, Rothia endophytica, Rothia mucilaginosa, Rothia nasimurium, Rubellimicrobium mesophilum, Rubellimicrobium roseum, Rubrobacter bracarensis, Rudaea cellulosilytica, Ruminococcus gnavus, Runella zeae, Saccharopolyspora rectivirgula, Salinicoccus qingdaonensis, Scardovia wiggsiae, Sediminibacterium ginsengisoli, Selenomonas artemidis, Selenomonas infelix, Selenomonas noxia, Selenomonas sputigena, Shewanella aestuarii, Shuttleworthia satelles, Simonsiella muelleri, Skermanella aerolata, Skermanella stibiiresistens, Slackia exigua, Smaragdicoccus niigatensis, Sneathia sanguinegens, Solirubrobacter soli, Sphingobacterium caeni, Sphingobacterium daejeonense, Sphingobacterium hotanense, Sphingobacterium kyonggiense, Sphingobacterium multivorum, Sphingobacterium nematocida, Sphingobacterium spiritivorum, Sphingobium amiense, Sphingobium indicum, Sphingobium lactosutens, Sphingobium subterraneum, Sphingomonas abaci, Sphingomonas aestuarii, Sphingomonas canadensis, Sphingomonas daechungensis, Sphingomonas dokdonensis, Sphingomonas echinoides, Sphingomonas fonticola, Sphingomonas fonticola, Sphingomonas formosensis, Sphingomonas gei, Sphingomonas hankookensis, Sphingomonas hankookensis, Sphingomonas koreensis, Sphingomonas kyeonggiensis, Sphingomonas laterariae, Sphingomonas mucosissima, Sphingomonas oligophenolica, Sphingomonas pseudosanguinis, Sphingomonas sediminicola, Sphingomonas yantingensis, Sphingomonas yunnanensis, Sphingopyxis indica, Spirosoma rigui, Sporacetigenium mesophilum, Sporocytophaga myxococcoides, Staphylococcus auricularis, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus hominis subsp. novobiosepticus, Staphylococcus lugdunensis, Staphylococcus pettenkoferi, Stenotrophomonas koreensis, Stenotrophomonas rhizophila, Stenotrophomonas rhizophila, Streptococcus agalactiae, Streptococcus canis, Streptococcus cristatus, Streptococcus gordonii, Streptococcus infantis, Streptococcus intermedius, Streptococcus mutans, Streptococcus oligofermentans, Streptococcus oralis, Streptococcus sanguinis, Streptomyces iconiensis, Streptomyces yanglinensis, Tabrizicola aquatica, Tahibacter caeni, Tannerella forsythia, Tepidicella xavieri, Tepidimonas fonticaldi, Terracoccus luteus, Tessaracoccus flavescens, Thermus thermophilus, Tianweitania sediminis, Tianweitania sediminis, Treponema amylovorum, Treponema denticola, Treponema lecithinolyticum, Treponema medium, Turicella otitidis, Turicibacter sanguinis, Undibacterium oligocarboniphilum, Undibacterium squillarum, Vagococcus salmoninarum, Varibaculum cambriense, Vibrio metschnikovii, Xanthobacter tagetidis, Xenophilus aerolatus, Xenophilus arseniciresistens, Yimella lutea, Zimmermannella alba, Zimmermannella bifida and/or Zoogloea caeni.

In other embodiments, the targeted bacteria cells are those commonly found in the vaginal microbiota and are, without limitation, Acinetobacter antiviralis, Acinetobacter baumannii, Acinetobacter calcoaceticus, Acinetobacter johnsonii, Actinobaculum massiliense, Actinobaculum schaalii, Actinomyces europaeus, Actinomyces graevenitzii, Actinomyces israelii, Actinomyces meyeri, Actinomyces naeslundii, Actinomyces neuii, Actinomyces odontolyticus, Actinomyces turicensis, Actinomyces urogenitalis, Actinomyces viscosus, Aerococcus christensenii, Aerococcus urinae, Aerococcus viridans, Aeromonas encheleia, Aeromonas salmonicida, Afipia massiliensis, Agrobacterium tumefaciens, Algoriphagus aquatilis, Allivibrio wodanis, Alistipes finegoldii, Alloiococcus otitis, Alloprevotella tannerae, Alloscardovia omnicolens, Alteretythrobacter epoxidivorans, Ammoniphilus oxalaticus, Amnibacterium kyonggiense, Anaerococcus hydrogenalis, Anaerococcus lactolyticus, Anaerococcus murdochii, Anaerococcus obesiensis, Anaerococcus prevotii, Anaerococcus tetradius, Anaerococcus vaginalis, Anaeroglobus geminatus, Anoxybacillus pushchinoensis, Aquabacterium parvum, Arcanobacterium phocae, Arthrobacter aurescens, Asticcacaulis excentricus, Atopobium minutum, Atopobium parvulum, Atopobium rimae, Atopobium vaginae, Avibacterium gaffinarum, Bacillus acidicola, Bacillus atrophaeus, Bacillus cereus, Bacillus cibi, Bacillus coahuilensis, Bacillus gaemokensis, Bacillus methanolicus, Bacillus oleronius, Bacillus pumilus, Bacillus shackletonii, Bacillus sporothermodurans, Bacillus subtilis, Bacillus wakoensis, Bacillus weihenstephanensis, Bacteroides barnesiae, Bacteroides coagulans, Bacteroides dorei, Bacteroides faecis, Bacteroides forsythus, Bacteroides fragilis, Bacteroides nordii, Bacteroides ovatus, Bacteroides salyersiae, Bacteroides stercoris, Bacteroides uniformis, Bacteroides vulgatus, Bacteroides xylanisolvens, Bacteroides zoogleoformans, Bamesiella viscericola, Bhargavaea cecembensis, Bifidobacterium adolescentis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium dentium, Bifidobacterium logum subsp. infantis, Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bifidobacterium scardovii, Bilophila wadsworthia, Blautia hydrogenotrophica, Blautia obeum, Blautia producta, Brachybacterium faecium, Bradyrhizobium japonicum, Brevibacterium mcbrellneri, Brevibacterium otitidis, Brevibacterium paucivorans, Bulleidia extructa, Burkholderia fungorum, Burkholderia phenoliruptix, Caldicellulosiruptor saccharolyticus, Caldimonas taiwanensis, Campylobacter gracilis, Campylobacter hominis, Campylobacter sputorum, Campylobacter ureolyticus, Capnocytophaga ochracea, Cardiobacterium hominis, Catonella morbi, Chlamydia trachomatis, Chlamydophila abortus, Chondromyces robustus, Chryseobacterium aquaticum, Citrobacter youngae, Cloacibacterium normanense, Clostridium cavendishii, Clostridium colicanis, Clostridium jejuense, Clostridium perfringens, Clostridium ramosum, Clostridium sordellii, Clostridium viride, Comamonas terrigena, Corynebacterium accolens, Corynebacterium appendicis, Corynebacterium coyleae, Corynebacterium glucuronolyticum, Corynebacterium glutamicum, Corynebacterium jeikeium, Corynebacterium kroppenstedtii, Corynebacterium lipophiloflavum, Corynebacterium minutissimum, Corynebacterium mucifaciens, Corynebacterium nuruki, Corynebacterium pseudo genitalium, Corynebacterium pyruviciproducens, Corynebacterium singulare, Corynebacterium striatum, Corynebacterium tube rculostearicum, Corynebacterium xerosis, Cryobacterium psychrophilum, Curtobacterium flaccumfaciens, Cutibacterium acnes, Cutibacterium avidum, Cytophaga xylanolytica, Deinococcus radiophilus, Delftia tsuruhatensis, Desulfovibrio desulfuricans, Dialister invisus, Dialister micraerophilus, Dialister pneumosintes, Dialister propionicifaciens, Dickeya chrysanthemi, Dorea longicatena, Eggerthella lenta, Eggerthia catenaformis, Eikenella corrodens, Enhydrobacter aerosaccus, Enterobacter asburiae, Enterobacter cloacae, Enterococcus avium, Enterococcus durans, Enterococcus faecalis, Enterococcus faecium, Enterococcus hirae, Erwinia persicina, Erwinia rhapontici, Erwinia toletana, Escherichia coli, Escherichia fergusonii, Eubacterium brachy, Eubacterium eligens, Eubacterium nodatum, Eubacterium rectale, Eubacterium saphenum, Eubacterium siraeum, Eubacterium sulci, Eubacterium yurii, Exiguobacterium acetylicum, Facklamia ignava, Faecalibacterium prausnitzii, Filifactor alocis, Finegoldia magna, Fusobacterium gonidiaformans, Fusobacterium nucleatum, Fusobacterium periodonticum, Gardnerella vaginalis, Gemella asaccharolytica, Gemella bergeri, Gemella haemolysans, Gemella sanguinis, Geobacillus stearothermophilus, Geobacillus thermocatenulatus, Geobacillus thermoglucosidasius, Geobacter grbiciae, Granulicatella elegans, Haemophilus ducreyi, Haemophilus haemolyticus, Haemophilus parahaemolyticus, Haemophilus parainfluenzae, Hafnia alvei, Halomonas meridiana, Halomonas phoceae, Halomonas venusta, Herbaspirillum seropedicae, Janthinobacterium lividum, Jonquetella anthropi, Klebsiella granulomatis, Klebsiella oxytoca, Klebsiella pneumoniae, Lactobacillus acidophilus, Lactobacillus amylovorus, Lactobacillus brevis, Lactobacillus coleohominis, Lactobacillus crispatus, Lactobacillus curvatus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus iners, Lactobacillus jensenii, Lactobacillus johnsonii, Lactobacillus kalixensis, Lactobacillus kefiranofaciens, Lactobacillus kimchicus, Lactobacillus kitasatonis, Lactobacillus mucosae, Lactobacillus panis, Lactobacillus paracasei, Lactobacillus plantarum, Lactobacillus pontis, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus salivarius, Lactobacillus ultunensis, Lactobacillus vaginalis, Lactococcus lactis, Leptotrichia buccalis, Leuconostoc carnosum, Leuconostoc citreum, Leuconostoc garlicum, Leuconostoc lactis, Leuconostoc mesenteroides, Lysinimonas kribbensis, Mageeibacillus indolicus, Maribacter orientalis, Marinomonas protea, Marinospirillum insulare, Massilia timonae, Megasphaera elsdenii, Megasphaera micronuciformis, Mesorhizobium amorphae, Methylobacterium radiotolerans, Methylotenera versatilis, Microbacterium halophilum, Micrococcus luteus, Microterricola viridarii, Mobiluncus curtisii, Mobiluncus mulieris, Mogibacterium timidum, Moorella glycerini, Moraxella osloensis, Morganella morganii, Moryella indoligenes, Murdochiella asaccharolytica, Mycoplasma alvi, Mycoplasma genitalium, Mycoplasma hominis, Mycoplasma muris, Mycoplasma salivarium, Negativicoccus succinicivorans, Neisseria flava, Neisseria gonorrhoeae, Neisseria mucosa, Neisseria subflava, Nevskia ramosa, Nevskia soli, Nitriliruptor alkaliphilus, Odoribacter splanchnicus, Oligella urethralis, Olsenella uli, Paenibacillus amylolyticus, Paenibacillus humicus, Paenibacillus pabuli, Paenibacillus pasadenensis, Paenibacillus pini, Paenibacillus validus, Pantoea agglomerans, Parabacteroides merdae, Paraburkholderia caryophylli, Paracoccus yeei, Parastreptomyces abscessus, Parvimonas micra, Pectobacterium betavasculorum, Pectobacterium carotovorum, Pediococcus acidilactici, Pediococcus ethanolidurans, Pedobacter alluvionis, Pedobacter wanjuense, Pelomonas aquatica, Peptococcus niger, Peptoniphilus asaccharolyticus, Peptoniphilus gorbachii, Peptoniphilus harei, Peptoniphilus indolicus, Peptoniphilus lacrimalis, Peptoniphilus massiliensis, Peptostreptococcus anaerobius, Peptostreptococcus massiliae, Peptostreptococcus stomatis, Photobacterium angustum, Photobacterium frigidiphilum, Photobacterium phosphoreum, Porphyromonas asaccharolytica, Porphyromonas bennonis, Porphyromonas catoniae, Porphyromonas endodontalis, Porphyromonas gingivalis, Porphyromonas somerae, Porphyromonas uenonis, Prevotella amnii, Prevotella baroniae, Prevotella bergensis, Prevotella bivia, Prevotella buccae, Prevotella buccalis, Prevotella colorans, Prevotella copri, Prevotella corporis, Prevotella dentalis, Prevotella denticola, Prevotella disiens, Prevotella intermedia, Prevotella loescheii, Prevotella marshii, Prevotella melaninogenica, Prevotella micans, Prevotella nigrescens, Prevotella oris, Prevotella pleuritidis, Prevotella ruminicola, Prevotella shahii, Prevotella stercorea, Prevotella timonensis, Prevotella veroralis, Propionimicrobium lymphophilum, Proteus mirabilis, Pseudomonas abietaniphila, Pseudomonas aeruginosa, Pseudomonas amygdali, Pseudomonas azotoformans, Pseudomonas chlororaphis, Pseudomonas cuatrocienegasensis, Pseudomonas fluorescens, Pseudomonas fulva, Pseudomonas lutea, Pseudomonas mucidolens, Pseudomonas oleovorans, Pseudomonas orientalis, Pseudomonas pseudoalcaligenes, Pseudomonas psychrophila, Pseudomonas putida, Pseudomonas synxantha, Pseudomonas syringae, Pseudomonas tolaasii, Pseudopropionibacterium propionicum, Rahnella aquatilis, Ralstonia pickettii, Ralstonia solanacearum, Raoultella planticola, Rhizobacter dauci, Rhizobium etli, Rhodococcus fascians, Rhodopseudomonas palustris, Roseburia intestinalis, Roseburia inulinivorans, Rothia mucilaginosa, Ruminococcus bromii, Ruminococcus gnavus, Ruminococcus torques, Sanguibacter keddieii, Sediminibacterium salmoneum, Selenomonas bovis, Serratia fonticola, Serratia liquefaciens, Serratia marcescens, Shewanella algae, Shewanella amazonensis, Shigella boydii, Shigella sonnei, Slackia exigua, Sneathia amnii, Sneathia sanguinegens, Solobacterium moorei, Sorangium cellulosum, Sphingobium amiense, Sphingobium japonicum, Sphingobium yanoikuyae, Sphingomonas wittichii, Sporosarcina aquimarina, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus capitis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus lugdunensis, Staphylococcus saprophyticus, Staphylococcus schleiferi, Staphylococcus simiae, Staphylococcus simulans, Staphylococcus wameri, Stenotrophomonas maltophilia, Stenoxybacter acetivorans, Streptococcus agalactiae, Streptococcus anginosus, Streptococcus australis, Streptococcus equinus, Streptococcus gallolyticus, Streptococcus infantis, Streptococcus intermedius, Streptococcus lutetiensis, Streptococcus marimammalium, Streptococcus mitis, Streptococcus mutans, Streptococcus oralis, Streptococcus parasanguinis, Streptococcus phocae, Streptococcus pseudo pneumoniae, Streptococcus salivarius, Streptococcus sanguinis, Streptococcus thermophilus, Sutterella wadsworthensis, Tannerella forsythia, Terrahaemophilus aromaticivorans, Treponema denticola, Treponema maltophilum, Treponema parvum, Treponema vincentii, Trueperella bernardiae, Turicella otitidis, Ureaplasma parvum, Ureaplasma urealyticum, Varibaculum cambriense, Variovorax paradoxus, Veillonella atypica, Veillonella dispar, Veillonella montpellierensis, Veillonella parvula, Virgibacillus proomii, Viridibacillus arenosi, Viridibacillus arvi, Weissella cibaria, Weissella soli, Xanthomonas campestris, Xanthomonas vesicatoria, Zobellia laminariae and/or Zoogloea ramigera.

In one embodiment, the targeted bacteria are Escherichia coli.

In one embodiment, the targeted bacteria are Cutibacterium acnes more specifically the acne related Cutibacterium acnes from the phylogroup IA1 or RT4, RT5, RT8, RT9, RT10 or Clonal Complex (CC) CC1, CC3, CC4, more specifically the ST1, ST3, ST4.

Bacteriophages used for preparing bacterial virus particles such as packaged phagemids, may target (e.g., specifically target) a bacterial cell from any one or more of the disclosed genus and/or species of bacteria to specifically deliver the payload.

In one embodiment, the targeted bacteria are pathogenic bacteria. The targeted bacteria can be virulent bacteria.

The targeted bacteria can be antibacterial resistance bacteria, preferably selected from the group consisting of extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli, ESBL Klebsiella pneumoniae, vancomycin-resistant Enterococcus (VRE), methicillin-resistant Staphylococcus aureus (MRSA), multidrug-resistant (MDR) Acinetobacter baumannii, MDR Enterobacter spp., and a combination thereof. Preferably, the targeted bacteria can be selected from the group consisting of extended-spectrum beta-lactamase-producing (ESBL) Escherichia coli strains.

Alternatively, the targeted bacterium can be a bacterium of the microbiome of a given species, preferably a bacterium of the human microbiota.

Bacterial Viruses

The bacterial virus particles are prepared from bacterial virus. The bacterial viruses are chosen in order to be able to introduce the payload into the targeted bacteria.

Bacterial viruses are preferably bacteriophages. Bacteriophages are obligate intracellular parasites that multiply inside bacteria by co-opting some or all of the host biosynthetic machinery. Phage genomes come in a variety of sizes and shapes (e.g., linear or circular). Most phages range in size from 24-200 nm in diameter. Phages contain nucleic acid (i.e., genome) and proteins, and may be enveloped by a lipid membrane. Depending upon the phage, the nucleic acid genome can be either DNA or RNA, and can exist in either circular or linear forms. The size of the phage genome varies depending upon the phage. The simplest phages have genomes that are only a few thousand nucleotides in size, while the more complex phages may contain more than 100,000 nucleotides in their genome, and in rare instances more than 1,000,000. The number and amount of individual types of protein in phage particles will vary depending upon the phage.

Optionally, the bacteriophage is selected from the Order Caudovirales consisting of, based on the taxonomy of Krupovic et al, Arch Virol, 2015:

-   -   family Myoviridae (such as, without limitation, genus         Cp220virus, Cp8virus, Ea214virus, Felixo1virus, Mooglevirus,         Suspvirus, Hp1virus, P2virus, Kayvirus, P100virus, Silviavirus,         Spo1virus, Tsarbombavirus, Twortvirus, Cc31virus, Jd18virus,         Js98virus, Kp15virus, Moonvirus, Rb49virus, Rb69virus, S16virus,         Schizot4virus, Sp18virus, T4virus, Cr3virus, Se1virus, V5virus,         Abouovirus, Agatevirus, Agrican357virus, Ap22virus, Arv1virus,         B4virus, Bastillevirus, Bc431virus, Bcep78virus, Bcepmuvirus,         Biquartavirus, Bxz1virus, Cd119virus, Cp51virus, Cvm10virus,         Eah2virus, E1virus, Hapunavirus, Jimmervirus, Kpp10virus,         M12virus, Machinavirus, Marthavirus, Msw3virus, Muvirus,         Myohalovirus, Nit1 virus, P1virus, Pakpunavirus, Pbunavirus,         Phikzvirus, Rheph4virus, Rsl2virus, Rslunavirus, Secunda5virus,         Sep1virus, Spn3virus, Svunavirus, Tg1virus, Vhmlvirus and         Wphvirus)     -   family Podoviridae (such as, without limitation, genus         Fri1virus, Kp32virus, Kp34virus, Phikmvvirus, Pradovirus,         Sp6virus, T7virus, Cp1virus, P68virus, Phi29virus, Nona33virus,         Pocjvirus, TI2011virus, Bcep22virus, Bpp1virus, Cba41virus,         Dfl12virus, Ea92virus, Epsilon15virus, F116virus, G7cvirus,         Jwalphavirus, Kf1virus, Kpp25virus, Lit1virus, Luz24virus,         Luz7virus, N4virus, Nonanavirus, P22virus, Pagevirus,         Phieco32virus, Prtbvirus, Sp58virus, Una961virus and Vp5virus)     -   family Siphoviridae (such as, without limitation, genus         Camvirus, Likavirus, R4virus, Acadianvirus, Coopervirus,         Pg1virus, Pipefishvirus, Rosebushvirus, Brujitavirus,         Che9cvirus, Hawkeyevirus, Plotvirus, Jerseyvirus, Klgvirus,         Sp31virus, Lmd1virus, Una4virus, Bongovirus, Reyvirus,         Buttersvirus, Charlievirus, Redivirus, Baxtervirus,         Nymphadoravirus, Bignuzvirus, Fishburnevirus, Phayoncevirus,         Kp36virus, Rogue1virus, Rtpvirus, T1virus, Tlsvirus, Ab18virus,         Amigovirus, Anatolevirus, Andromedavirus, Attisvirus,         Barnyardvirus, Bernal13virus, Biseptimavirus, Bronvirus,         C2virus, C5virus, Cba181virus, Cbastvirus, Cecivirus, Che8virus,         Chivirus, Cjw1virus, Corndogvirus, Cronusvirus, D3112virus,         D3virus, Decurrovirus, Demosthenesvirus, Doucettevirus,         E125virus, Eiauvirus, Ff47virus, Gaiavirus, Gilesvirus,         Gordonvirus, Gordtnkvirus, Harrisonvirus, Hk578virus, Hk97virus,         Jenstvirus, Jwxvirus, Kelleziovirus, Korravirus, L5virus,         Lambdavirus, Laroyevirus, Liefievirus, Marvinvirus, Mudcatvirus,         N15virus, Nonagvirus, Np1virus, Omegavirus, P12002virus,         P12024virus, P23virus, P70virus, Pa6virus, Pamx74virus,         Patiencevirus, Pbi1virus, Pepy6virus, Pfr1virus, Phic31virus,         Phicbkvirus, Phietavirus, Phife1virus, Phijl1virus, Pis4avirus,         Psavirus, Psimunavirus, Rdj1virus, Rer2virus, Sap6virus,         Send513virus, Septima3virus, Seuratvirus, Sextaecvirus,         Sfi11virus, Sfi21dt1virus, Sitaravirus, Sk1virus, Slashvirus,         Smoothievirus, Soupsvirus, Spbetavirus, Ssp2virus, T5virus,         Tankvirus, Tin2virus, Titanvirus, Tm4virus, Tp21virus,         Tp84virus, Triavirus, Trigintaduovirus, Vegasvirus,         Vendettavirus, Wbetavirus, Wildcatvirus, Wizardvirus, Woesvirus,         Xp10virus, Ydn12virus and Yuavirus)     -   family Ackermannviridae (such as, without limitation, genus         Ag3virus, Limestonevirus, Cba120virus and Vi1virus)

Optionally, the bacteriophage is not part of the Order Caudovirales but from families with Unassigned order such as, without limitation, family Tectiviridae (such as genus Alphatectivirus, Betatectivirus), family Corticoviridae (such as genus Corticovirus), family Inoviridae (such as genus Fibrovirus, Habenivirus, Inovirus, Lineavirus, Plectrovirus, Saetivirus, Vespertiliovirus), family Cystoviridae (such as genus Cystovirus), family Leviviridae (such as genus Allolevivirus, Levivirus), family Microviridae (such as genus Alpha3microvirus, G4microvirus, Phix174microvirus, Bdellomicrovirus, Chlamydiamicrovirus, Spiromicrovirus) and family Plasmaviridae (such as genus Plasmavirus).

Optionally, the bacteriophage is targeting Archea not part of the Order Caudovirales but from families with Unassigned order such as, without limitation, Ampullaviridae, FuselloViridae, Globuloviridae, Guttaviridae, Lipothrixviridae, Pleolipoviridae, Rudiviridae, Salterprovirus and Bicaudaviridae.

A non-exhaustive listing of bacterial genera and their known host-specific bacteria viruses is presented in the following paragraphs. Synonyms and spelling variants are indicated in parentheses. Homonyms are repeated as often as they occur (e.g., D, D, d). Unnamed phages are indicated by “NN” beside their genus and their numbers are given in parentheses.

Bacteria of the genus Actinomyces can be infected by the following phages: Av-I, Av-2, Av-3, BF307, CTI, CT2, CT3, CT4, CT6, CT7, CT8 and 1281.

Bacteria of the genus Aeromonas can be infected by the following phages: AA-I, Aeh2, N, PMI, TP446, 3, 4, 11, 13, 29, 31, 32, 37, 43, 43-10T, 51, 54, 55R.1, 56, 56RR2, 57, 58, 59.1, 60, 63, Aehl, F, PM2, 1, 25, 31, 40RR2.8t, (syn=44R), (syn=44RR2.8t), 65, PM3, PM4, PM5 and PM6.

Bacteria of the genus Bacillus can be infected by the following phages: A, aizI, AI-K-I, B, BCJAI, BCI, BC2, BLLI, BLI, BP142, BSLI, BSL2, BSI, BS3, BS8, BS15, BS18, BS22, BS26, BS28, BS31, BS104, BS105, BS106, BTB, B1715V1, C, CK-I, ColI, CorI, CP-53, CS-I, CSi, D, D, D, D5, entl, FP8, FP9, FSi, FS2, FS3, FS5, FS8, FS9, G, GH8, GT8, GV-I, GV-2, GT-4, g3, gl2, gl3, gl4, gl6, gl7, g21, g23, g24, g29, H2, kenl, KK-88, Kuml, Kyul, J7W-1, LP52, (syn=LP-52), L7, Mexl, MJ-I, mor2, MP-7, MPIO, MP12, MP14, MP15, Neol, N^(o) 2, N5, N6P, PBCI, PBLA, PBPI, P2, S-a, SF2, SF6, ShaI, SilI, SP02, (syn=φSPP1), SPβ, STI, STi, SU-11, t, TbI, Tb2, Tb5, TbIO, Tb26, Tb51, Tb53, Tb55, Tb77, Tb97, Tb99, Tb560, Tb595, Td8, Td6, Tdl5, TgI, Tg4, Tg6, Tg7, Tg9, TglI, TglI, Tgl3, Tgl5, Tg21, TinI, Tin7, Tin8, Tinl3, Tm3, TocI, TogI, tolI, TP-1, TP-10vir, TP-15c, TP-16c, TP-17c, TP-19, TP35, TP51, TP-84, Tt4, Tt6, type A, type B, type C, type D, type E, Tφ3, VA-9, W, wx23, wx26, YunI, α, γ, p I, φmed-2, φT, φμ-4, φ3T, φ75, φIO5, (syn=φIO5), IA, IB, 1-97A, 1-97B, 2, 2, 3, 3, 3, 5, 12, 14, 20, 30, 35, 36, 37, 38, 41C, 51, 63, 64, 138D, I, II, IV, NN-Bacillus (13), aleI, ARI, AR2, AR3, AR7, AR9, Bace-11, (syn=11), Bastille, BLI, BL2, BL3, BL4, BL5, BL6, BL8, BL9, BP124, BS28, BS80, Ch, CP-51, CP-54, D-5, dart, dent, DP-7, entl, FoSi, FoS2, FS4, FS6, FS7, G, gall, gamma, GEI, GF-2, GSi, GT-I, GT-2, GT-3, GT-4, GT-5, GT-6, GT-7, GV-6, gl5, 19, 110, ISi, K, MP9, MP13, MP21, MP23, MP24, MP28, MP29, MP30, MP32, MP34, MP36, MP37, MP39, MP40, MP41, MP43, MP44, MP45, MP47, MP50, NLP-I, No. I, N17, N19, PBSI, PKI, PMBI, PMB12, PMJI, S, SPOI, SP3, SP5, SP6, SP7, SP8, SP9, SPIO, SP-15, SP50, (syn=SP-50), SP82, SST, subI, SW, Tg8, Tgl2, Tgl3, Tgl4, thuI, thuΛ, thuS, Tin4, Tin23, TP-13, TP33, TP50, TSP-I, type V, type VI, V, Vx, β22, φe, φNR2, φ25, φ63, 1, 1, 2, 2C, 3NT, 4, 5, 6, 7, 8, 9, 10, 12, 12, 17, 18, 19, 21, 138, III, 4 (B. megateriwn), 4 (B. sphaericus), AR13, BPP-IO, BS32, BS107, BI, B2, GA-1, GP-10, GV-3, GV-5, g8, MP20, MP27, MP49, Nf, PPS, PP6, SF5, Tgl8, TP-I, Versailles, φI5, φ29, 1-97, 837/IV, mï-Bacillus (1), BatIO, BSLIO, BSLI 1, BS6, BSI I, BS16, BS23, BSIOI, BS102, gl8, morI, PBLI, SN45, thu2, thu3, TmI, Tm2, TP-20, TP21, TP52, type F, type G, type IV, HN-BacMus (3), BLE, (syn=θc), BS2, BS4, BS5, BS7, BIO, B12, BS20, BS21, F, MJ-4, PBA12, AP50, AP50-04, AP50-11, AP50-23, AP50-26, AP50-27 and Bam35. The following Bacillus-specific phages are defective: DLP10716, DLP-11946, DPBS, DPB12, DPB21, DPB22, DPB23, GA-2, M, No. IM, PBLB, PBSH, PBSV, PBSW, PBSX, PBSY, PBSZ, phi, SPa, type 1 and μ.

Bacteria of the genus Bacteroides can be infected by the following phages: crAss-phage, ad I2, Baf-44, Baf-48B, Baf-64, Bf-I, Bf-52, B40-8, FI, βI, φAI, φBrOI, φBrO2, 11, 67.1, 67.3, 68.1, mt-Bacteroides (3), Bf42, Bf71, HN-Bdellovibrio (1) and BF-41.

Bacteria of the genus Bordetella can be infected by the following phages: 134 and NN-Bordetella (3).

Bacteria of the genus Borrellia can be infected by the following phages: NN-Borrelia (1) and NN-Borrelia (2).

Bacteria of the genus Brucella can be infected by the following phages: A422, Bk, (syn=Berkeley), BM29, FOi, (syn=FOI), (syn=FQI), D, FP2, (syn=FP2), (syn=FD2), Fz, (syn=Fz75/13), (syn=Firenze 75/13), (syn=Fi), Fi, (syn=FI), Fim, (syn=FIm), (syn=Fim), FiU, (syn=FIU), (syn=FiU), F2, (syn=F2), F3, (syn=F3), F4, (syn=F4), F5, (syn=F5), F6, F7, (syn=F7), F25, (syn=F25), (syn=£25), F25U, (syn=F25u), (syn=F25U), (syn=F25V), F44, (syn-F44), F45, (syn=F45), F48, (syn=F48), I, Im, M, MC/75, M51, (syn=M85), P, (syn=D), S708, R, Tb, (syn=TB), (syn=Tbilisi), W, (syn=Wb), (syn=Weybridge), X, 3, 6, 7, 10/1, (syn=10), (syn=F8), (syn=F8), 12m, 24/11, (syn=24), (syn=F9), (syn=F9), 45/111, (syn=45), 75, 84, 212/XV, (syn=212), (syn=Fi0), (syn=FIO), 371/XXIX, (syn=371), (syn=Fn), (syn=FI I) and 513.

Bacteria of the genus Burkholderia can be infected by the following phages: CP75, NN-Burkholderia (1) and 42.

Bacteria of the genus Campylobacter can be infected by the following phages: C type, NTCC12669, NTCC12670, NTCC12671, NTCC12672, NTCC12673, NTCC12674, NTCC12675, NTCC12676, NTCC12677, NTCC12678, NTCC12679, NTCC12680, NTCC12681, NTCC12682, NTCC12683, NTCC12684, 32f, 111c, 191, NN-Campylobacter (2), Vfi-6, (syn=V19), VfV-3, V2, V3, V8, V16, (syn=Vfi-1), V19, V20(V45), V45, (syn=V-45) and NN-Campylobacter (1).

Bacteria of the genus Chlamydia can be infected by the following phage: ChpI.

Bacteria of the genus Clostridium can be infected by the following phages: CAKI, CA5, Ca7, CEβ, (syn=10), CEγ, CldI, c-n71, c-203 Tox-, DEβ, (syn=ID), (syn=IDt0X+), HM3, KMI, KT, Ms, NAI, (syn=Naltox+), PA135Oe, Pfó, PL73, PL78, PL81, PI, P50, P5771, P19402, ICt0X+, 2Ct0X\ 2D3 (syn=2Dt0X+), 3C, (syn=3Ctox+), 4C, (syn=4Ct0X+), 56, III-I, NN-Clostridium (61), NBIt0X+, αI, CAI, HMT, HM2, PFI5 P-23, P-46, Q-05, Q-oe, Q-16, Q-21, Q-26, Q-40, Q-46, S111, SA02, WA01, WA03, Wm, W523, 80, C, CA2, CA3, CPTI, CPT4, cI, c4, c5, HM7, H11/A1, H18/Ax, FWS23, Hi58ZA1, K2ZA1, K21ZS23, ML, NA2t0X; Pf2, Pf3, Pf4, S9ZS3, S41ZA1, S44ZS23, α2, 41, 112ZS23, 214/S23, 233/Ai, 234/S23, 235/S23, II-I, II-2, II-3, NN-Clostridium (12), CAI, FI, K, S2, 1, 5 and NN-Clostridium (8).

Bacteria of the genus Corynebacterium can be infected by the following phages: CGKI (defective), A, A2, A3, A101, A128, A133, A137, A139, A155, A182, B, BF, B17, B18, B51, B271, B275, B276, B277, B279, B282, C, capi, CCI, CGI, CG2, CG33, CL31, Cog, (syn=CG5), D, E, F, H, H-I, hqi, hq2, 11ZH33, li/31, J, K, K, (syn=Ktox″), L, L, (syn=Ltox+), M, MC-I, MC-2, MC-3, MC-4, MLMa, N, O, ovi, ov2, ov3, P, P, R, RP6, RS29, S, T, U, UB1, ub2, UH1, UH3, uh3, uh5, uh6, β, (syn=βtox+), βhv64, βvir, γ, (syn=γtoχ−), γI9, δ, (syn=δ′ox+), p, (syn=ptoχ−), ϕ9, φ984, ω, IA, 1/1180, 2, 2/1180, 5/1180, 5ad/9717, 7/4465, 8/4465, 8ad/10269, 10/9253, 13Z9253, 15/3148, 21/9253, 28, 29, 55, 2747, 2893, 4498 and 5848.

Bacteria of the genus Enterococcus are infected by the following phage: DF78, FI, F2, 1, 2, 4, 14, 41, 867, DI, SB24, 2BV, 182, 225, C2, C2F, E3, E62, DS96, H24, M35, P3, P9, SBIOI, S2, 2BII, 5, 182a, 705, 873, 881, 940, 1051, 1057, 21096C, NN-Enterococcus (1), PEI, FI, F3, F4, VD13, 1, 200, 235 and 341.

Bacteria of the genus Erysipelothrix can be infected by the following phage: NN-Eiysipelothrix (1).

Bacteria of the genus Escherichia can be infected by the following phages: BW73, B278, D6, D108, E, El, E24, E41, FI-2, FI-4, FI-5, HI8A, FfI8B, i, MM, Mu, (syn=mu), (syn=MuI), (syn=Mu-I), (syn=MU-I), (syn=MuI), (syn=μ), 025, PhI-5, Pk, PSP3, PI, PID, P2, P4 (defective), SI, Wφ, φK13, φR73 (defective), φI, φ2, φ7, φ92, ψ (defective), 7 A, 8φ, 9φ, 15 (defective), 18, 28-1, 186, 299, HH-Escherichia (2), AB48, CM, C4, C16, DD-VI, (syn=Dd-Vi), (syn=DDVI), (syn=DDVi), E4, E7, E28, FII, FI3, H, HI, H3, H8, K3, M, N, ND-2, ND-3, ND4, ND-5, ND6, ND-7, Ox-I (syn=OXI), (syn=HF), Ox-2 (syn=0x2), (syn=0X2), Ox-3, Ox-4, Ox-5, (syn=0X5), Ox-6, (syn=66F), (syn=φ66t), (syn=φ66t-)5 0111, PhI-I, RB42, RB43, RB49, RB69, S, Sal-I, Sal-2, Sal-3, Sal-4, Sal-5, Sal-6, TC23, TC45, TulI*-6, (syn=TulI*), TulP-24, TulI*46, TulP-60, T2, (syn=ganuTia), (syn=γ), (syn=PC), (syn=P.C.), (syn=T-2), (syn=T2), (syn=P4), T4, (syn=T-4), (syn=T4), T6, T35, αI, 1, IA, 3, (syn=Ac3), 3A, 3T+, (syn=3), (syn=MI), 5φ, (syn=φ5), 9266Q, CFO103, HK620, J, K, KIF, m59, no. A, no. E, no. 3, no. 9, N4, sd, (syn=Sd), (syn=SD), (syn=Sa)3 (syn=sd), (syn=SD), (syn=CD), T3, (syn=T-3), (syn=T3), T7, (syn=T-7), (syn=T7), WPK, W31, ΔH, φC3888, φK3, φK7, φK12, φV-1, φ04-CF, φ05, φ06, φ07, φI, φI.2, φ20, φ95, φ263, φIO92, φI, φII, (syn=φW), Ω8, 1, 3, 7, 8, 26, 27, 28-2, 29, 30, 31, 32, 38, 39, 42, 933W, NN-Escherichia (1), Esc-7-11, AC30, CVX-5, CI, DDUP, ECI, EC2, E21, E29, FI, F26S, F27S, Hi, HK022, HK97, (syn=ϕHK97), HK139, HK253, HK256, K7, ND-1, no.D, PA-2, q, S2, TI, (syn=α), (syn=P28), (syn=T-I), (syn=Tx), T3C, T5, (syn=T-5), (syn=T5), UC-I, w, β4, γ2, λ (syn=lambda), (syn=ϕλ), ϕD326, ϕγ, ϕ06, ϕ7, ϕ10, φ80, χ, (syn=χi), (syn=φχ), (syn=φχi), 2, 4, 4A, 6, 8A, 102, 150, 168, 174, 3000, AC6, AC7, AC28, AC43, AC50, AC57, AC81, AC95, HK243, KIO, ZG/3A, 5, 5A, 21EL, H19-J, 933H, O157 typing phages 1 to 16, JES-2013, 121Q, 172-1, 1720a-02, ADB-2, AKFV33, av-05, bVEcoS_AHP42, bV_EcoS_AHP24, bC_EcoS_AHS24, bV_EcoS_AKS96, CBA120.

Bacteria of the genus Fusobacterium are infected by the following phage: NN-Fusobacterium (2), fv83-554/3, fv88-531/2, 227, fv2377, fv2527 and fv8501.

Bacteria of the genus Haemophilus are infected by the following phage: HPI, S2 and N3.

Bacteria of the genus Helicobacter are infected by the following phage: HPI and {circumflex over ( )}{circumflex over ( )} Helicobacter (1).

Bacteria of the genus Klebsiella are infected by the following phage: AIO-2, KI4B, KI6B, K19, (syn=K19), KI14, KI15, KI21, KI28, KI29, KI32, KI33, KI35, KI106B, KI171B, KI181B, KI832B, AIO-1, AO-I, AO-2, AO-3, FC3-10, K, KI1, (syn=KII), KI2, (syn=KI2), KI3, (syn=K13), (syn=KI 70/11), KI4, (syn=K14), KI5, (syn=K15), KI6, (syn=K16), KI7, (syn=K17), KI8, (syn=K18), KI19, (syn=K19), KI27, (syn=K127), KI31, (syn=K131), KI35, KI171B, II, VI, IX, CI-I, KI4B, KI8, KI11, KI12, KI13, KI16, KI17, KI18, KI20, KI22, KI23, KI24, KI26, KI30, KI34, KI106B, KIi65B, KI328B, KLXI, K328, P5046, 11, 380, III, IV, VII, VIII, FC3-11, KI2B, (syn=K12B), KI25, (syn=K125), KI42B, (syn=K142), (syn=K142B), KI181B, (syn=KII 81), (syn=K1181B), KI765/!, (syn=KI765/1), KI842B, (syn=KI832B), KI937B, (syn=KI937B), LI, φ28, 7, 231, 483, 490, 632 and 864/100.

Bacteria of the genus Leptospira are infected by the following phage: LEI, LE3, LE4 and ˜NN-Leptospira (1).

Bacteria of the genus Listeria are infected by the following phage: A511, 01761, 4211, 4286, (syn=BO54), A005, A006, A020, A500, A502, A511, AI 18, A620, A640, B012, B021, B024, B025, B035, B051, B053, B054, B055, B056, BIOI, BI IO, B545, B604, B653, C707, D441, HSO47, HIOG, H8/73, H19, H21, H43, H46, H107, H108, HI IO, H163/84, H312, H340, H387, H391/73, H684/74, H924A, PSA, U153, φMLUP5, (syn=P35), 00241, 00611, 02971A, 02971C, 5/476, 5/911, 5/939, 5/11302, 5/11605, 5/11704, 184, 575, 633, 699/694, 744, 900, 1090, 1317, 1444, 1652, 1806, 1807, 1921/959, 1921/11367, 1921/11500, 1921/11566, 1921/12460, 1921/12582, 1967, 2389, 2425, 2671, 2685, 3274, 3550, 3551, 3552, 4276, 4277, 4292, 4477, 5337, 5348/11363, 5348/11646, 5348/12430, 5348/12434, 10072, 11355C, 11711A, 12029, 12981, 13441, 90666, 90816, 93253, 907515, 910716 and NN-Listeria (15).

Bacteria of the genus Morganella are infected by the following phage: 47.

Bacteria of the genus Mycobacterium are infected by the following phage: 13, AGI, ALi, ATCC 11759, A2, B.C3, BG2, BKI, BK5, butyricum, B-I, B5, B7, B30, B35, Clark, CI, C2, DNAIII, DSP1, D4, D29, GS4E, (syn=GS4E), GS7, (syn=GS-7), (syn=GS7), IPa, lacticola, Legendre, Leo, L5, (syn=ϕL-5), MC-I, MC-3, MC-4, minetti, MTPHI I, Mx4, MyF3P/59a, phlei, (syn=phlei 1), phlei 4, Polonus II, rabinovitschi, smegmatis, TM4, TM9, TMIO, TM20, Y7, YIO, φ630, IB, IF, IH, 1/1, 67, 106, 1430, BI, (syn=Bol), B24, D, D29, F-K, F-S, HP, Polonus I, Roy, RI, (syn=RI-Myb), (syn=Ri), 11, 31, 40, 50, 103a, 103b, 128, 3111-D, 3215-D and NN-Mycobacterium (1).

Bacteria of the genus Neisseria are infected by the following phage: Group I, group II and NPI.

Bacteria of the genus Nocardia are infected by the following phage: MNP8, NJ-L, NS-8, N5 and TtiN-Nocardia.

Bacteria of the genus Proteus are infected by the following phage: Pm5, 13vir, 2/44, 4/545, 6/1004, 13/807, 20/826, 57, 67b, 78, 107/69, 121, 9/0, 22/608, 30/680, PmI, Pm3, Pm4, Pm6, Pm7, Pm9, PmIO, PmI I, Pv2, πI, φm, 7/549, 9B/2, 10A/31, 12/55, 14, 15, 16/789, 17/971, 19A/653, 23/532, 25/909, 26/219, 27/953, 32A/909, 33/971, 34/13, 65, 5006M, 7480b, VI, 13/3a, Clichy 12, π2600, φχ7, 1/1004, 5/742, 9, 12, 14, 22, 24/860, 2600/D52, Pm8 and 24/2514.

Bacteria of the genus Providencia are infected by the following phage: PL25, PL26, PL37, 9211/9295, 9213/921 Ib, 9248, 7/R49, 7476/322, 7478/325, 7479, 7480, 9000/9402 and 9213/921 Ia.

Bacteria of the genus Pseudomonas are infected by the following phage: PfI, (syn=Pf-I), Pf2, Pf3, PP7, PRRI, 7s, im-Pseudomonas (1), AI-I, AI-2, B 17, B89, CB3, Col 2, Col 11, Col 18, Col 21, C154, C163, C167, C2121, E79, F8, ga, gb, H22, K1, M4, N2, Nu, PB-I, (syn=PBI), pfI6, PMN17, PPI, PP8, PsaI, PsPI, PsP2, PsP3, PsP4, PsP5, PS3, PS17, PTB80, PX4, PX7, PYOI, PYO2, PYO5, PYO6, PYO9, PYOIO, PYO13, PYO14, PYO16, PYO18, PYO19, PYO20, PYO29, PYO32, PYO33, PYO35, PYO36, PYO37, PYO38, PYO39, PYO41, PYO42, PYO45, PYO47, PYO48, PYO64, PYO69, PYO103, PIK, SLPI, SL2, S2, UNL-I, wy, Yai, Ya4, Yan, φBE, φCTX, φC17, φKZ, (syn=ϕKZ), φ-LT, ϕmu78, φNZ, φPLS-1, φST-1, φW-14, φ-2, 1/72, 2/79, 3, 3/DO, 4/237, 5/406, 6C, 6/6660, 7, 7v, 7/184, 8/280, 9/95, 10/502, 11/DE, 12/100, 12S, 16, 21, 24, 25F, 27, 31, 44, 68, 71, 95, 109, 188, 337, 352, 1214, HN-Pseudomonas (23), A856, B26, CI-I, CI-2, C5, D, gh-1, FI 16, HF, H90, K5, K6, KI 04, K109, K166, K267, N4, N5, O6N-25P, PE69, Pf, PPN25, PPN35, PPN89, PPN91, PP2, PP3, PP4, PP6, PP7, PP8, PP56, PP87, PPI 14, PP206, PP207, PP306, PP651, Psp231a, Pssy401, Pssy9220, psi, PTB2, PTB20, PTB42, PXI, PX3, PXIO, PX12, PX14, PYO70, PYO71, R, SH6, SH133, tf, Ya5, Ya7, φBS, ϕKf77, φ-MC, ϕmnF82, φPLS27, φPLS743, φS-1, 1, 2, 2, 3, 4, 5, 6, 7, 7, 8, 9, 10, 11, 12, 12B, 13, 14, 15, 14, 15, 16, 17, 18, 19, 20, 20, 21, 21, 22, 23, 23, 24, 25, 31, 53, 73, 119x, 145, 147, 170, 267, 284, 308, 525, NN-Pseudomonas (5), af, A7, B3, B33, B39, BI-I, C22, D3, D37, D40, D62, D3112, F7, FIO, g, gd, ge, gξ HwI2, Jb 19, KFI, L^(o), OXN-32P, O6N-52P, PCH-I, PC13-1, PC35-1, PH2, PH51, PH93, PH132, PMW, PM13, PM57, PM61, PM62, PM63, PM69, PM105, PMI 13, PM681, PM682, PO4, PPI, PP4, PP5, PP64, PP65, PP66, PP71, PP86, PP88, PP92, PP401, PP711, PP891, Pssy41, Pssy42, Pssy403, Pssy404, Pssy420, Pssy923, PS4, PS-IO, Pz, SDI, SLI, SL3, SL5, SM, φC5, φCI I, φCI I-1, φC13, φC15, φMO, φX, φO4, φI I, φ240, 2, 2F, 5, 7m, 11, 13, 13/441, 14, 20, 24, 40, 45, 49, 61, 73, 148, 160, 198, 218, 222, 236, 242, 246, 249, 258, 269, 295, 297, 309, 318, 342, 350, 351, 357-1, 400-1, HN-Pseudomonas (6), G101, M6, M6a, LI, PB2, PssyI5, Pssy4210, Pssy4220, PYO12, PYO34, PYO49, PYO50, PYO51, PYO52, PYO53, PYO57, PYO59, PYO200, PX2, PX5, SL4, φO3, φO6 and 1214.

Bacteria of the genus Rickettsia are infected by the following phage: NN-Rickettsia.

Bacteria of the genus Salmonella are infected by the following phage: b, Beccles, CT, d, Dundee, f, Fels 2, GI, GUI, GVI, GVIII, k, K, i, j, L, 01, (syn=0-1), (syn=O1), (syn=O-I), (syn=7), 02, 03, P3, P9a, PIO, Sab3, Sab5, SanIS, SanI7, SI, Taunton, ViI, (syn=ViI), 9, imSalmonella (1), N-I, N-5, N-IO, N-17, N-22, 11, 12, 16-19, 20.2, 36, 449C/C178, 966A/C259, a, B.A.O.R., e, G4, GUI, L, LP7, M, MG40, N-18, PSA68, P4, P9c, P22, (syn=P22), (syn=PLT22), (syn=PLT22), P22aI, P22-4, P22-7, P22-11, SNT-I, SNT-2, SP6, Villi, VilV, ViV, ViVI, ViVII, Worksop, Sj5, ε34, 1,37, 1(40), (syn=φI[40]), 1,422, 2, 2.5, 3b, 4, 5, 6,14(18), 8, 14(6,7), 10, 27, 28B, 30, 31, 32, 33, 34, 36, 37, 39, 1412, SNT-3, 7-11, 40.3, c, C236, C557, C625, C966N, g, GV, G5, GI 73, h, IRA, Jersey, MB78, P22-1, P22-3, P22-12, SabI, Sab2, Sab2, Sab4, SanI, San2, San3, San4, San6, San7, San8, San9, SanI3, SanI4, SanI6, SanI8, SanI9, San20, San21, San22, San23, San24, San25, San26, SasLI, SasL2, SasL3, SasL4, SasL5, SIBL, SII, ViII, φI, 1, 2, 3a, 3a1, 1010, Ym-Salmonella (1), N-4, SasL6 and 27.

Bacteria of the genus Serratia are infected by the following phage: A2P, PS20, SMB3, SMP, SMP5, SM2, V40, V56, ic, ϕPCP-3, ϕPCP-6, 3M, 10/1a, 20A, 34CC, 34H, 38T, 345G, 345P, 501B, SMB2, SMP2, BC, BT, CW2, CW3, CW4, CW5, Lt232, L2232, L34, L.228, SLP, SMPA, V.43, σ, φCWI, ϕCP6-1, ϕCP6-2, ϕCP6-5, 3T, 5, 8, 9F, 10/1, 20E, 32/6, 34B, 34CT, 34P, 37, 41, 56, 56D, 56P, 6OP, 61/6, 74/6, 76/4, 101/8900, 226, 227, 228, 229F, 286, 289, 290F, 512, 764a, 2847/10, 2847/1Oa, L.359 and SMBI.

Bacteria of the genus Shigella are infected by the following phage: Fsa, (syn=a), FSD2d, (syn=D2d), (syn=W2d), FSD2E, (syn=W2e), fv, F6, f7.8, H-Sh, PES, P90, SfII, Sh, SHm, SHrv, (syn=HIV), SHvi, (syn=HVI), SHVvm, (syn=HVIII), SKγ66, (syn=gamma 66), (syn=yββ), (syn=γ66b), SKm, (syn=SIIIb)5 (syn=UI), SKw, (syn=Siva), (syn=IV), SIC™, (syn=SIVA), (syn=IVA), SKvi, (syn=KVI), (syn=Svi), (syn=VI), SKvm, (syn=Svm), (syn=VIII), SKVΠIA, (syn=SvmA), (syn=VIIIA), STvi, STK, STx1, STxn, S66, W2, (syn=D2c), (syn=D20), φI, φIVb 3-SO-R, 8368-SO-R, F7, (syn=FS7), (syn=K29), FIO, (syn=FSIO), (syn=K31), I1, (syn=alfa), (syn=FSa), (syn=KI 8), (syn=α), I2, (syn=a), (syn=KI9), SG33, (syn=G35), (syn=SO-35/G), SG35, (syn=SO-55/G), SG3201, (syn=SO-3201/G), SHn, (syn=HII), SHv, (syn=SHV), SHx, SHX, SKn, (syn=K2), (syn=KII), (syn=Sn), (syn=SsII), (syn=II), SKrv, (syn=Sm), (syn=SsIV), (syn=IV), SK1Va, (syn=Swab), (syn=SsIVa), (syn=IVa), SKV, (syn=K4), (syn=KV), (syn=SV), (syn=SsV), (syn=V), SKx, (syn=K9), (syn=KX), (syn=SX), (syn=SsX), (syn=X), STV, (syn=T35), (syn=35-50-R), STvm, (syn=T8345), (syn=8345-SO-S-R), W1, (syn=D8), (syn=FSD8), W2a, (syn=D2A), (syn=FS2a), DD-2, Sf6, FSi, (syn=FI), SF6, (syn=F6), SG42, (syn=SO-42/G), SG3203, (syn=SO-3203/G), SKF12, (syn=SsF12), (syn=F12), (syn=F12), STn, (syn=1881-SO-R), γ66, (syn=gamma 66a), (syn=Ssγ66), φ2, BII, DDVII, (syn=DD7), FSD2b, (syn=W2B), FS2, (syn=F2), (syn=F2), FS4, (syn=F4), (syn=F4), FS5, (syn=F5), (syn=F5), FS9, (syn=F9), (syn=F9), FI I, P2-S0-S, SG36, (syn=SO-36/G), (syn=G36), SG3204, (syn=SO-3204/G), SG3244, (syn=SO-3244/G), SHi, (syn=HI), SHvrr, (syn=HVII), SHK, (syn=HIX), SHx1, SHxrr, (syn=HXn), SKI, KI, (syn=S1), (syn=SsI), SKVII, (syn=KVII), (syn=Svrr), (syn=SsVII), SKIX, (syn=KIX), (syn=S1x), (syn=SsIX), SKXII, (syn=KXII), (syn=Sxn), (syn=SsXII), STi, STffI, STrv, STVi, STvrr, S70, S206, U2-S0-S, 3210-SO-S, 3859-SO-S, 4020-SO-S, φ3, φ5, φ7, φ8, φ9, φIO, φI I, φI 3, φI4, φI8, SHm, (syn=Hπi), SHχi, (syn=HXt) and SKxI, (syn=KXI), (syn=Sχi), (syn=SsXI), (syn=XI).

Bacteria of the genus Staphylococcus are infected by the following phage: A, EW, K, Ph5, Ph9, PhIO, PhI3, PI, P2, P3, P4, P8, P9, PIO, RG, SB-i, (syn=Sb-I), S3K, Twort, ϕSK311, φ812, 06, 40, 58, 119, 130, 131, 200, 1623, STCI, (syn=stcI), STC2, (syn=stc2), 44AHJD, 68, ACI, AC2, A6″C″, A9″C″, b581, CA-I, CA-2, CA-3, CA-4, CA-5, DI I, L39x35, L54a, M42, NI, N2, N3, N4, N5, N7, N8, NIO, Ni I, N12, N13, N14, N16, Ph6, Phl2, Phl4, UC-18, U4, U15, SI, S2, S3, S4, S5, X2, Z1, φB5-2, φD, ω, 11, (syn=φI I), (syn=P11-M15), 15, 28, 28A, 29, 31, 31B, 37, 42D, (syn=P42D), 44A, 48, 51, 52, 52A, (syn=P52A), 52B, 53, 55, 69, 71, (syn=P71), 71A, 72, 75, 76, 77, 79, 80, 80α, 82, 82A, 83 A, 84, 85, 86, 88, 88A, 89, 90, 92, 95, 96, 102, 107, 108, 111, 129-26, 130, 130A, 155, 157, 157A, 165, 187, 275, 275A, 275B, 356, 456, 459, 471, 471A, 489, 581, 676, 898, 1139, 1154A, 1259, 1314, 1380, 1405, 1563, 2148, 2638A, 2638B, 2638C, 2731, 2792A, 2792B, 2818, 2835, 2848A, 3619, 5841, 12100, AC3, A8, AIO, A13, b594n, D, HK2, N9, N15, P52, P87, SI, S6, Z4, φRE, 3A, 3B, 3C, 6, 7, 16, 21, 42B, 42C, 42E, 44, 47, 47A5 47C, 51, 54, 54x1, 70, 73, 75, 78, 81, 82, 88, 93, 94, 101, 105, 110, 115, 129/16, 174, 594n, 1363/14, 2460 and mS-Staphylococcus (1).

Bacteria of the genus Streptococcus are infected by the following phage: EJ-I, NN-Streptococais (1), a, CI, FL0Ths, H39, Cp-I, Cp-5, Cp-7, Cp-9, Cp-IO, AT298, A5, aIO/JI, aIO/J2, aIO/J5, aIO/J9, A25, BTI I, b6, CAI, c20-I, c20-2, DP-I, Dp-4, DTI, ET42, eIO, FA101, FEThs, Fκ, FKKIOI, FKLIO, FKP74, FKH, FLOThs, FyIOI, fI, F10, F20140/76, g, GT-234, HB3, (syn=HB-3), HB-623, HB-746, M102, O1205, φ01205, PST, PO, PI, P2, P3, P5, P6, P8, P9, P9, P12, P13, P14, P49, P50, P51, P52, P53, P54, P55, P56, P57, P58, P59, P64, P67, P69, P71, P73, P75, P76, P77, P82, P83, P88, sc, sch, sf, SfII 1, (syn=SFiI I), (syn=φSFiII), (syn=ϕSfiI I), (syn=φSfiI I), sfiI9, (syn=SFiI9), (syn=φSFiI9), (syn=φSfiI9), Sfi21, (syn=SFi21), (syn=φSFi21), (syn=φSfi21), ST0, STX, st2, ST2, ST4, S3, (syn=φS3), s265, ℠17, φ42, ϕ57, φ80, φ81, φ82, φ83, φ84, φ85, φ86, φ87, φ88, φ89, φ90, φ91, φ92, φ93, φ94, φ95, φ96, φ97, φ98, φ99, φIOO, φIOI, φIO2, φ227, ϕ7201, ωI, ω2, ω3, ω4, ω5, ω6, ω8, ωIO, 1, 6, 9, 1OF, 12/12, 14, 17SR, 19S, 24, 50/33, 50/34, 55/14, 55/15, 70/35, 70/36, 71/ST15, 71/45, 71/46, 74F, 79/37, 79/38, 80/J4, 80/J9, 80/ST16, 80/15, 80/47, 80/48, 101, 103/39, 103/40, 121/41, 121/42, 123/43, 123/44, 124/44, 337/ST17 and mStreptococcus (34).

Bacteria of the genus Treponema are infected by the following phage: NN-Treponema (1).

Bacteria of the genus Vibrio are infected by the following phage: CTXϕ, fs, (syn=si), fs2, Ivpf5, VfI2, Vf33, VPIϕ, VSK, v6, 493, CP-TI, ET25, kappa, KI39, Labol, )XN-69P, OXN-86, O6N-21P, PB-I, P147, rp-1, SE3, VA-I, (syn=VcA-I), VcA-2, VPI, VP2, VP4, VP7, VP8, VP9, VPIO, VP17, VP18, VP19, X29, (syn=29 d'Herelle), t, ϕHAWI-1, ϕHAWI-2, ϕHAWI-3, ϕHAWI-4, ϕHAWI-5, ϕHAWI-6, ϕHAWI-7, XHAWI-8, ϕHAWI-9, ϕHAWI-10, ϕHCI-1, ϕHC1-2, ϕHC1-3, ϕHC1-4, ϕHC2-1, >HC2-2, ϕHC2-3, ϕHC2-4, ϕHC3-1, ϕHC3-2, ϕHC3-3, ϕHD1S-1, ϕHD1S-2, ϕHD2S-1, ϕHD2S-2, ϕHD2S-3, ϕHD2S-4, ϕHD2S-5, ϕHDO-1, ϕHDO-2, ϕHDO-3, ϕHDO-4, ϕHDO-5, ϕHDO-6, ϕKL-33, ϕKL-34, ϕKL-35, ϕKL-36, ϕKWH-2, ϕKWH-3, ϕKWH-4, ϕMARQ-1, ϕMARQ-2, ϕMARQ-3, ϕMOAT-1, ϕO139, ϕPEL1A-1, ϕPEL1A-2, ϕPEL8A-1, ϕPEL8A-2, ϕPEL8A-3, ϕPEL8C-1, ϕPEL8C-2, ϕPEL13A-1, ϕPEL13B-1, ϕPEL13B-2, ϕPEL13B-3, ϕPEL13B-4, ϕPEL13B-5, ϕPEL13B-6, ϕPEL13B-7, ϕPEL13B-8, ϕPEL13B-9, ϕPEL13B-10, φVP143, φVP253, ϕ16, φI38, 1-II, 5, 13, 14, 16, 24, 32, 493, 6214, 7050, 7227, II, (syn=group II), (syn==φ2), V, VIII, ˜m-Vibrio (13), KVP20, KVP40, nt-1, O6N-22P, P68, eI, e2, e3, e4, e5, FK, G, I, K, nt-6, NI, N2, N3, N4, N5, O6N-34P, OXN-72P, OXN-85P, OXN-100P, P, Ph-I, PL163/10, Q, S, T, φ92, 1-9, 37, 51, 57, 70A-8, 72A-4, 72A-10, 110A-4, 333, 4996, I (syn=group I), III (syn=group III), VI, (syn=A-Saratov), VII, IX, X, HN-Vibrio (6), pAI, 7, 7-8, 70A-2, 71A-6, 72A-5, 72A-8, 108A-10, 109A-6, 109A-8, IIOA-1, IIOA-5, IIOA-7, by-1, OXN-52P, P13, P38, P53, P65, P108, Pill, TP13 VP3, VP6, VP12, VP13, 70A-3, 70A-4, 70A-10, 72A-1, 108A-3, 109-B1, 110A-2, 149, (syn=T149), IV, (syn=group IV), NN-Vibrio (22), VPS, VPII, VP15, VP16, αI, α2, α3a, α3b, 353B and HN-Vibrio (7).

Bacteria of the genus Yersinia are infected by the following phage: H, H-I, H-2, H-3, H-4, Lucas 110, Lucas 303, Lucas 404, YerA3, YerA7, YerA20, YerA41, 3/M64-76, 5/G394-76, 6/C753-76, 8/C239-76, 9/F18167, 1701, 1710, PST, 1/F2852-76, D'Herelle, EV, H, Kotljarova, PTB, R, Y, YerA41, φYerO3-12, 3, 4/01324-76, 7/F783-76, 903, 1/M6176 and Yer2AT.

More preferably, the bacteriophage is selected in the group consisting of Salmonella virus SKML39, Shigella virus AG3, Dickeya virus Limestone, Dickeya virus RC2014, Escherichia virus CBA120, Escherichia virus PhaxI, Salmonella virus 38, Salmonella virus Det7, Salmonella virus GG32, Salmonella virus PM10, Salmonella virus SFP10, Salmonella virus SH19, Salmonella virus SJ3, Escherichia virus ECML4, Salmonella virus Marshall, Salmonella virus Maynard, Salmonella virus SJ2, Salmonella virus STML131, Salmonella virus ViI, Erwinia virus Ea2809, Klebsiella virus 0507KN21, Serratia virus IME250, Serratia virus MAM1, Campylobacter virus CP21, Campylobacter virus CP220, Campylobacter virus CPt10, Campylobacter virus IBB35, Campylobacter virus CP81, Campylobacter virus CP30A, Campylobacter virus CPX, Campylobacter virus NCTC12673, Erwinia virus Ea214, Erwinia virus M7, Escherichia virus AYO145A, Escherichia virus EC6, Escherichia virus HY02, Escherichia virus JH2, Escherichia virus TP1, Escherichia virus VpaE1, Escherichia virus wV8, Salmonella virus FelixO1, Salmonella virus HB2014, Salmonella virus Mushroom, Salmonella virus UAB87, Citrobacter virus Moogle, Citrobacter virus Mordin, Escherichia virus SUSP1, Escherichia virus SUSP2, Aeromonas virus phiO18P, Haemophilus virus HP1, Haemophilus virus HP2, Pasteurella virus F108, Vibrio virus KI39, Vibrio virus Kappa, Burkholderia virus phi52237, Burkholderia virus phiE122, Burkholderia virus phiE202, Escherichia virus 186, Escherichia virus P4, Escherichia virus P2, Escherichia virus Wphi, Mannheimia virus PHL101, Pseudomonas virus phiCTX, Ralstonia virus RSA1, Salmonella virus Fels2, Salmonella virus PsP3, Salmonella virus SopEphi, Yersinia virus L413C, Staphylococcus virus G1, Staphylococcus virus G15, Staphylococcus virus JD7, Staphylococcus virus K, Staphylococcus virus MCE2014, Staphylococcus virus P108, Staphylococcus virus Rodi, Staphylococcus virus S253, Staphylococcus virus S25-4, Staphylococcus virus SA12, Listeria virus A511, Listeria virus P100, Staphylococcus virus Remus, Staphylococcus virus SA11, Staphylococcus virus Stau2, Bacillus virus Camphawk, Bacillus virus SPO1, Bacillus virus BCP78, Bacillus virus TsarBomba, Staphylococcus virus Twort, Enterococcus virus phiEC24C, Lactobacillus virus Lb338-1, Lactobacillus virus LP65, Enterobacter virus PG7, Escherichia virus CC31, Klebsiella virus JD18, Klebsiella virus PKO111, Escherichia virus Bp7, Escherichia virus IME08, Escherichia virus JS10, Escherichia virus JS98, Escherichia virus QL01, Escherichia virus VR5, Enterobacter virus Eap3, Klebsiella virus KP15, Klebsiella virus KP27, Klebsiella virus Matisse, Klebsiella virus Miro, Citrobacter virus Merlin, Citrobacter virus Moon, Escherichia virus JSE, Escherichia virus phi1, Escherichia virus RB49, Escherichia virus HX01, Escherichia virus J509, Escherichia virus RB69, Shigella virus UTAM, Salmonella virus S16, Salmonella virus STML198, Vibrio virus KVP40, Vibrio virus nt1, Vibrio virus ValKK3, Escherichia virus VR7, Escherichia virus VR20, Escherichia virus VR25, Escherichia virus VR26, Shigella virus SP18, Escherichia virus AR1, Escherichia virus C40, Escherichia virus E112, Escherichia virus ECML134, Escherichia virus HY01, Escherichia virus Ime09, Escherichia virus RB3, Escherichia virus RB14, Escherichia virus T4, Shigella virus Pss1, Shigella virus ShfI2, Yersinia virus D1, Yersinia virus PST, Acinetobacter virus 133, Aeromonas virus 65, Aeromonas virus Aeh1, Escherichia virus RB16, Escherichia virus RB32, Escherichia virus RB43, Pseudomonas virus 42, Cronobacter virus CR3, Cronobacter virus CR8, Cronobacter virus CR9, Cronobacter virus PBES02, Pectobacterium virus phiTE, Cronobacter virus GAP31, Escherichia virus 4MG, Salmonella virus SE1, Salmonella virus SSE121, Escherichia virus FFH2, Escherichia virus FV3, Escherichia virus JES2013, Escherichia virus V5, Brevibacillus virus Abouo, Brevibacillus virus Davies, Bacillus virus Agate, Bacillus virus Bobb, Bacillus virus Bp8pC, Erwinia virus Deimos, Erwinia virus Ea35-70, Erwinia virus RAY, Erwinia virus Simmy50, Erwinia virus SpecialG, Acinetobacter virus AB1, Acinetobacter virus AB2, Acinetobacter virus AbC62, Acinetobacter virus AP22, Arthrobacter virus ArV1, Arthrobacter virus Trina, Bacillus virus AvesoBmore, Bacillus virus B4, Bacillus virus Bigbertha, Bacillus virus Riley, Bacillus virus Spock, Bacillus virus Troll, Bacillus virus Bastille, Bacillus virus CAM003, Bacillus virus Bc431, Bacillus virus Bcp1, Bacillus virus BCP82, Bacillus virus BM15, Bacillus virus Deepblue, Bacillus virus JBP901, Burkholderia virus Bcep1, Burkholderia virus Bcep43, Burkholderia virus Bcep781, Burkholderia virus BcepNY3, Xanthomonas virus OP2, Burkholderia virus BcepMu, Burkholderia virus phiE255, Aeromonas virus 44RR2, Mycobacterium virus Alice, Mycobacterium virus Bxz1, Mycobacterium virus Dandelion, Mycobacterium virus HyRo, Mycobacterium virus 13, Mycobacterium virus Nappy, Mycobacterium virus Sebata, Clostridium virus phiC2, Clostridium virus phiCD27, Clostridium virus phiCD119, Bacillus virus CP51, Bacillus virus JL, Bacillus virus Shanette, Escherichia virus CVM10, Escherichia virus ep3, Erwinia virus Asesino, Erwinia virus EaH2, Pseudomonas virus EL, Halomonas virus HAP1, Vibrio virus VP882, Brevibacillus virus Jimmer, Brevibacillus virus Osiris, Pseudomonas virus Ab03, Pseudomonas virus KPP10, Pseudomonas virus PAKP3, Sinorhizobium virus M7, Sinorhizobium virus M12, Sinorhizobium virus N3, Erwinia virus Machina, Arthrobacter virus Brent, Arthrobacter virus Jawnski, Arthrobacter virus Martha, Arthrobacter virus Sonny, Edwardsiella virus MSW3, Edwardsiella virus PEi21, Escherichia virus Mu, Shigella virus SfMu, Halobacterium virus phiH, Bacillus virus Grass, Bacillus virus NIT1, Bacillus virus SPG24, Aeromonas virus 43, Escherichia virus P1, Pseudomonas virus CAb1, Pseudomonas virus CAb02, Pseudomonas virus JG004, Pseudomonas virus PAKP1, Pseudomonas virus PAKP4, Pseudomonas virus PaP1, Burkholderia virus BcepF1, Pseudomonas virus 141, Pseudomonas virus Ab28, Pseudomonas virus DL60, Pseudomonas virus DL68, Pseudomonas virus F8, Pseudomonas virus JG024, Pseudomonas virus KPP12, Pseudomonas virus LBL3, Pseudomonas virus LMA2, Pseudomonas virus PB1, Pseudomonas virus SN, Pseudomonas virus PA7, Pseudomonas virus phiKZ, Rhizobium virus RHEph4, Ralstonia virus RSF1, Ralstonia virus RSL2, Ralstonia virus RSL1, Aeromonas virus 25, Aeromonas virus 31, Aeromonas virus Aes12, Aeromonas virus Aes508, Aeromonas virus AS4, Stenotrophomonas virus IME13, Staphylococcus virus IPLAC1C, Staphylococcus virus SEP1, Salmonella virus SPN3US, Bacillus virus 1, Geobacillus virus GBSV1, Yersinia virus R1RT, Yersinia virus TG1, Bacillus virus G, Bacillus virus PBS1, Microcystis virus Ma-LMM01, Vibrio virus MAR, Vibrio virus VHML, Vibrio virus VP585, Bacillus virus BPS13, Bacillus virus Hakuna, Bacillus virus Megatron, Bacillus virus WPh, Acinetobacter virus AB3, Acinetobacter virus Abp1, Acinetobacter virus Fri1, Acinetobacter virus IME200, Acinetobacter virus PD6A3, Acinetobacter virus PDAB9, Acinetobacter virus phiAB1, Escherichia virus K30, Klebsiella virus K5, Klebsiella virus KI1, Klebsiella virus Kp1, Klebsiella virus KP32, Klebsiella virus KpV289, Klebsiella virus F19, Klebsiella virus K244, Klebsiella virus Kp2, Klebsiella virus KP34, Klebsiella virus KpV41, Klebsiella virus KpV71, Klebsiella virus KpV475, Klebsiella virus SU503, Klebsiella virus SU552A, Pantoea virus Limelight, Pantoea virus Limezero, Pseudomonas virus LKA1, Pseudomonas virus phiKMV, Xanthomonas virus f20, Xanthomonas virus f30, Xylella virus Prado, Erwinia virus Era103, Escherichia virus K5, Escherichia virus KI-5, Escherichia virus KIE, Salmonella virus SP6, Escherichia virus T7, Kluyvera virus Kvp1, Pseudomonas virus gh1, Prochlorococcus virus PSSP7, Synechococcus virus P60, Synechococcus virus SynS, Streptococcus virus Cp1, Streptococcus virus Cp7, Staphylococcus virus 44AHJD, Streptococcus virus C1, Bacillus virus B103, Bacillus virus GA1, Bacillus virus phi29, Kurthia virus 6, Actinomyces virus Av1, Mycoplasma virus P1, Escherichia virus 24B, Escherichia virus 933W, Escherichia virus Min27, Escherichia virus PA28, Escherichia virus Stx2 II, Shigella virus 7502Stx, Shigella virus POCJ13, Escherichia virus 191, Escherichia virus PA2, Escherichia virus TL2011, Shigella virus VASD, Burkholderia virus Bcep22, Burkholderia virus BcepiI02, Burkholderia virus BcepmigI, Burkholderia virus DC1, Bordetella virus BPP1, Burkholderia virus BcepC6B, Cellulophaga virus Cba41, Cellulophaga virus Cba172, Dinoroseobacter virus DFL12, Erwinia virus Ea9-2, Erwinia virus Frozen, Escherichia virus phiV10, Salmonella virus Epsilon15, Salmonella virus SPN1S, Pseudomonas virus F116, Pseudomonas virus H66, Escherichia virus APECS, Escherichia virus APEC7, Escherichia virus Bp4, Escherichia virus EC1UPM, Escherichia virus ECBP1, Escherichia virus G7C, Escherichia virus IME11, Shigella virus Sb1, Achromobacter virus Axp3, Achromobacter virus JWAlpha, Edwardsiella virus KF1, Pseudomonas virus KPP25, Pseudomonas virus R18, Pseudomonas virus Ab09, Pseudomonas virus LIT1, Pseudomonas virus PA26, Pseudomonas virus Ab22, Pseudomonas virus CHU, Pseudomonas virus LUZ24, Pseudomonas virus PAA2, Pseudomonas virus PaP3, Pseudomonas virus PaP4, Pseudomonas virus TL, Pseudomonas virus KPP21, Pseudomonas virus LUZ7, Escherichia virus N4, Salmonella virus 9NA, Salmonella virus SP069, Salmonella virus BTP1, Salmonella virus HK620, Salmonella virus P22, Salmonella virus ST64T, Shigella virus Sf6, Bacillus virus Page, Bacillus virus Palmer, Bacillus virus Pascal, Bacillus virus Pony, Bacillus virus Pookie, Escherichia virus 172-1, Escherichia virus ECB2, Escherichia virus NJ01, Escherichia virus phiEco32, Escherichia virus Septima11, Escherichia virus SU10, Brucella virus Pr, Brucella virus Tb, Escherichia virus Pollock, Salmonella virus FSL SP-058, Salmonella virus FSL SP-076, Helicobacter virus 1961P, Helicobacter virus KHP30, Helicobacter virus KHP40, Hamiltonella virus APSE1, Lactococcus virus KSY1, Phormidium virus WMP3, Phormidium virus WMP4, Pseudomonas virus 119X, Roseobacter virus SIO1, Vibrio virus VpV262, Vibrio virus VC8, Vibrio virus VP2, Vibrio virus VP5, Streptomyces virus Amela, Streptomyces virus phiCAM, Streptomyces virus Aaronocolus, Streptomyces virus Caliburn, Streptomyces virus Danzina, Streptomyces virus Hydra, Streptomyces virus Izzy, Streptomyces virus Lannister, Streptomyces virus Lika, Streptomyces virus Sujidade, Streptomyces virus Zemlya, Streptomyces virus ELB20, Streptomyces virus R4, Streptomyces virus phiHau3, Mycobacterium virus Acadian, Mycobacterium virus Baee, Mycobacterium virus Reprobate, Mycobacterium virus Adawi, Mycobacterium virus Bane1, Mycobacterium virus BrownCNA, Mycobacterium virus Chrisnmich, Mycobacterium virus Cooper, Mycobacterium virus JAMaL, Mycobacterium virus Nigel, Mycobacterium virus Stinger, Mycobacterium virus Vincenzo, Mycobacterium virus Zemanar, Mycobacterium virus Apizium, Mycobacterium virus Manad, Mycobacterium virus Oline, Mycobacterium virus Osmaximus, Mycobacterium virus Pg1, Mycobacterium virus Soto, Mycobacterium virus Suffolk, Mycobacterium virus Athena, Mycobacterium virus Bernardo, Mycobacterium virus Gadjet, Mycobacterium virus Pipefish, Mycobacterium virus Godines, Mycobacterium virus Rosebush, Mycobacterium virus Babsiella, Mycobacterium virus Brujita, Mycobacterium virus Che9c, Mycobacterium virus Sbash, Mycobacterium virus Hawkeye, Mycobacterium virus Plot, Salmonella virus AG11, Salmonella virus Ent1, Salmonella virus f18SE, Salmonella virus Jersey, Salmonella virus L13, Salmonella virus LSPA1, Salmonella virus SE2, Salmonella virus SETP3, Salmonella virus SETP7, Salmonella virus SETP13, Salmonella virus SP101, Salmonella virus SS3e, Salmonella virus wksI3, Escherichia virus KIG, Escherichia virus KIH, Escherichia virus K1ind1, Escherichia virus K1ind2, Salmonella virus SP31, Leuconostoc virus Lmd1, Leuconostoc virus LN03, Leuconostoc virus LN04, Leuconostoc virus LN12, Leuconostoc virus LN6B, Leuconostoc virus P793, Leuconostoc virus 1A4, Leuconostoc virus Ln8, Leuconostoc virus Ln9, Leuconostoc virus LN25, Leuconostoc virus LN34, Leuconostoc virus LNTR3, Mycobacterium virus Bongo, Mycobacterium virus Rey, Mycobacterium virus Butters, Mycobacterium virus Michelle, Mycobacterium virus Charlie, Mycobacterium virus Pipsqueaks, Mycobacterium virus Xeno, Mycobacterium virus Panchino, Mycobacterium virus Phrann, Mycobacterium virus Redi, Mycobacterium virus Skinnyp, Gordonia virus BaxterFox, Gordonia virus Yeezy, Gordonia virus Kita, Gordonia virus Zirinka, Gorrdonia virus Nymphadora, Mycobacterium virus Bignuz, Mycobacterium virus Brusacoram, Mycobacterium virus Donovan, Mycobacterium virus Fishburne, Mycobacterium virus Jebeks, Mycobacterium virus Malithi, Mycobacterium virus Phayonce, Enterobacter virus F20, Klebsiella virus 1513, Klebsiella virus KLPN1, Klebsiella virus KP36, Klebsiella virus PKP126, Klebsiella virus Sushi, Escherichia virus AHP42, Escherichia virus AHS24, Escherichia virus AKS96, Escherichia virus C119, Escherichia virus E41c, Escherichia virus Eb49, Escherichia virus Jk06, Escherichia virus KP26, Escherichia virus Rogue1, Escherichia virus ACGM12, Escherichia virus Rtp, Escherichia virus ADB2, Escherichia virus JMPW1, Escherichia virus JMPW2, Escherichia virus T1, Shigella virus PSf2, Shigella virus ShfI1, Citrobacter virus Stevie, Escherichia virus TLS, Salmonella virus SP126, Cronobacter virus Esp2949-1, Pseudomonas virus Ab18, Pseudomonas virus Ab19, Pseudomonas virus PaMx11, Arthrobacter virus Amigo, Propionibacterium virus Anatole, Propionibacterium virus B3, Bacillus virus Andromeda, Bacillus virus Blastoid, Bacillus virus Curly, Bacillus virus Eoghan, Bacillus virus Finn, Bacillus virus Glittering, Bacillus virus Riggi, Bacillus virus Taylor, Gordonia virus Attis, Mycobacterium virus Barnyard, Mycobacterium virus Konstantine, Mycobacterium virus Predator, Mycobacterium virus Bernal13, Staphylococcus virus 13, Staphylococcus virus 77, Staphylococcus virus 108PVL, Mycobacterium virus Bron, Mycobacterium virus Faith1, Mycobacterium virus Joedirt, Mycobacterium virus Rumpelstiltskin, Lactococcus virus bIL67, Lactococcus virus c2, Lactobacillus virus c5, Lactobacillus virus Ld3, Lactobacillus virus Ld17, Lactobacillus virus Ld25A, Lactobacillus virus LLKu, Lactobacillus virus phiLdb, Cellulophaga virus Cba121, Cellulophaga virus Cba171, Cellulophaga virus Cba181, Cellulophaga virus ST, Bacillus virus 250, Bacillus virus IEBH, Mycobacterium virus Ardmore, Mycobacterium virus Avani, Mycobacterium virus Boomer, Mycobacterium virus Che8, Mycobacterium virus Che9d, Mycobacterium virus Deadp, Mycobacterium virus Dlane, Mycobacterium virus Dorothy, Mycobacterium virus Dotproduct, Mycobacterium virus Drago, Mycobacterium virus Fruitloop, Mycobacterium virus Gumbie, Mycobacterium virus lbhubesi, Mycobacterium virus Llij, Mycobacterium virus Mozy, Mycobacterium virus Mutaforma13, Mycobacterium virus Pacc40, Mycobacterium virus PMC, Mycobacterium virus Ramsey, Mycobacterium virus Rockyhorror, Mycobacterium virus SG4, Mycobacterium virus Shaunal, Mycobacterium virus Shilan, Mycobacterium virus Spartacus, Mycobacterium virus Taj, Mycobacterium virus Tweety, Mycobacterium virus Wee, Mycobacterium virus Yoshi, Salmonella virus Chi, Salmonella virus FSLSP030, Salmonella virus FSLSP088, Salmonella virus iEPS5, Salmonella virus SPN19, Mycobacterium virus 244, Mycobacterium virus Bask21, Mycobacterium virus CJW1, Mycobacterium virus Eureka, Mycobacterium virus Kostya, Mycobacterium virus Porky, Mycobacterium virus Pumpkin, Mycobacterium virus Sirduracell, Mycobacterium virus Toto, Mycobacterium virus Corndog, Mycobacterium virus Firecracker, Rhodobacter virus RcCronus, Pseudomonas virus D3112, Pseudomonas virus DMS3, Pseudomonas virus FHA0480, Pseudomonas virus LPB1, Pseudomonas virus MP22, Pseudomonas virus MP29, Pseudomonas virus MP38, Pseudomonas virus PA1KOR, Pseudomonas virus D3, Pseudomonas virus PMG1, Arthrobacter virus Decurro, Gordonia virus Demosthenes, Gordonia virus Katyusha, Gordonia virus Kvothe, Propionibacterium virus B22, Propionibacterium virus Doucette, Propionibacterium virus E6, Propionibacterium virus G4, Burkholderia virus phi6442, Burkholderia virus phi1026b, Burkholderia virus phiE125, Edwardsiella virus eiAU, Mycobacterium virus Ff47, Mycobacterium virus Muddy, Mycobacterium virus Gaia, Mycobacterium virus Giles, Arthrobacter virus Captnmurica, Arthrobacter virus Gordon, Gordonia virus GordTnk2, Paenibacillus virus Harrison, Escherichia virus EK99P1, Escherichia virus HK578, Escherichia virus JL1, Escherichia virus SSL2009a, Escherichia virus YD2008s, Shigella virus EP23, Sodalis virus SO1, Escherichia virus HK022, Escherichia virus HK75, Escherichia virus HK97, Escherichia virus HK106, Escherichia virus HK446, Escherichia virus HK542, Escherichia virus HK544, Escherichia virus HK633, Escherichia virus mEp234, Escherichia virus mEp235, Escherichia virus mEpX1, Escherichia virus mEpX2, Escherichia virus mEp043, Escherichia virus mEp213, Escherichia virus mEp237, Escherichia virus mEp390, Escherichia virus mEp460, Escherichia virus mEp505, Escherichia virus mEp506, Brevibacillus virus Jenst, Achromobacter virus 83-24, Achromobacter virus JWX, Arthrobacter virus Kellezzio, Arthrobacter virus Kitkat, Arthrobacter virus Bennie, Arthrobacter virus DrRobert, Arthrobacter virus Glenn, Arthrobacter virus HunterDalle, Arthrobacter virus Joann, Arthrobacter virus Korra, Arthrobacter virus Preamble, Arthrobacter virus Pumancara, Arthrobacter virus Wayne, Mycobacterium virus Alma, Mycobacterium virus Arturo, Mycobacterium virus Astro, Mycobacterium virus Backyardigan, Mycobacterium virus BBPiebs31, Mycobacterium virus Benedict, Mycobacterium virus Bethlehem, Mycobacterium virus Billknuckles, Mycobacterium virus Bruns, Mycobacterium virus Bxb1, Mycobacterium virus Bxz2, Mycobacterium virus Che12, Mycobacterium virus Cuco, Mycobacterium virus D29, Mycobacterium virus Doom, Mycobacterium virus Ericb, Mycobacterium virus Euphoria, Mycobacterium virus George, Mycobacterium virus Gladiator, Mycobacterium virus Goose, Mycobacterium virus Hammer, Mycobacterium virus Heldan, Mycobacterium virus Jasper, Mycobacterium virus JC27, Mycobacterium virus Jeffabunny, Mycobacterium virus JHC117, Mycobacterium virus KBG, Mycobacterium virus Kssjeb, Mycobacterium virus Kugel, Mycobacterium virus L5, Mycobacterium virus Lesedi, Mycobacterium virus LHTSCC, Mycobacterium virus lockley, Mycobacterium virus Marcell, Mycobacterium virus Microwolf, Mycobacterium virus Mrgordo, Mycobacterium virus Museum, Mycobacterium virus Nepal, Mycobacterium virus Packman, Mycobacterium virus Peaches, Mycobacterium virus Perseus, Mycobacterium virus Pukovnik, Mycobacterium virus Rebeuca, Mycobacterium virus Redrock, Mycobacterium virus Ridgecb, Mycobacterium virus Rockstar, Mycobacterium virus Saintus, Mycobacterium virus Skipole, Mycobacterium virus Solon, Mycobacterium virus Switzer, Mycobacterium virus SWU1, Mycobacterium virus Ta17a, Mycobacterium virus Tiger, Mycobacterium virus Timshel, Mycobacterium virus Trixie, Mycobacterium virus Turbido, Mycobacterium virus Twister, Mycobacterium virus U2, Mycobacterium virus Violet, Mycobacterium virus Wonder, Escherichia virus DE3, Escherichia virus HK629, Escherichia virus HK630, Escherichia virus Lambda, Arthrobacter virus Laroye, Mycobacterium virus Halo, Mycobacterium virus Liefie, Mycobacterium virus Marvin, Mycobacterium virus Mosmoris, Arthrobacter virus Circum, Arthrobacter virus Mudcat, Escherichia virus N15, Escherichia virus 9g, Escherichia virus JenKI, Escherichia virus JenP1, Escherichia virus JenP2, Pseudomonas virus NP1, Pseudomonas virus PaMx25, Mycobacterium virus Baka, Mycobacterium virus Courthouse, Mycobacterium virus Littlee, Mycobacterium virus Omega, Mycobacterium virus Optimus, Mycobacterium virus Thibault, Polaribacter virus P12002L, Polaribacter virus P12002S, Nonlabens virus P12024L, Nonlabens virus P12024S, Thermus virus P23-45, Thermus virus P74-26, Listeria virus LP26, Listeria virus LP37, Listeria virus LP110, Listeria virus LP114, Listeria virus P70, Propionibacterium virus ATCC29399BC, Propionibacterium virus ATCC29399BT, Propionibacterium virus Attacne, Propionibacterium virus Keiki, Propionibacterium virus Kubed, Propionibacterium virus Lauchelly, Propionibacterium virus MrAK, Propionibacterium virus Ouroboros, Propionibacterium virus P91, Propionibacterium virus P105, Propionibacterium virus P144, Propionibacterium virus P1001, Propionibacterium virus P1.1, Propionibacterium virus P100A, Propionibacterium virus P100D, Propionibacterium virus P101A, Propionibacterium virus P104A, Propionibacterium virus PA6, Propionibacterium virus Pacnes201215, Propionibacterium virus PAD20, Propionibacterium virus PAS50, Propionibacterium virus PHLOO9M11, Propionibacterium virus PHL025M00, Propionibacterium virus PHL037M02, Propionibacterium virus PHL041M10, Propionibacterium virus PHL060L00, Propionibacterium virus PHL067M01, Propionibacterium virus PHL070N00, Propionibacterium virus PHL071N05, Propionibacterium virus PHL082M03, Propionibacterium virus PHL092M00, Propionibacterium virus PHL095N00, Propionibacterium virus PHL111M01, Propionibacterium virus PHL112N00, Propionibacterium virus PHL113M01, Propionibacterium virus PHL114L00, Propionibacterium virus PHL116M00, Propionibacterium virus PHL117M00, Propionibacterium virus PHL117M01, Propionibacterium virus PHL132N00, Propionibacterium virus PHL141N00, Propionibacterium virus PHL151M00, Propionibacterium virus PHL151N00, Propionibacterium virus PHL152M00, Propionibacterium virus PHL163M00, Propionibacterium virus PHL171M01, Propionibacterium virus PHL179M00, Propionibacterium virus PHL194M00, Propionibacterium virus PHL199M00, Propionibacterium virus PHL301M00, Propionibacterium virus PHL308M00, Propionibacterium virus Pirate, Propionibacterium virus Procrass1, Propionibacterium virus SKKY, Propionibacterium virus Solid, Propionibacterium virus Stormborn, Propionibacterium virus Wizzo, Pseudomonas virus PaMx28, Pseudomonas virus PaMx74, Mycobacterium virus Patience, Mycobacterium virus PBI1, Rhodococcus virus Pepy6, Rhodococcus virus Poco6, Propionibacterium virus PFR1, Streptomyces virus phiBT1, Streptomyces virus phiC31, Streptomyces virus TG1, Caulobacter virus Karma, Caulobacter virus Magneto, Caulobacter virus phiCbK, Caulobacter virus Rogue, Caulobacter virus Swift, Staphylococcus virus 11, Staphylococcus virus 29, Staphylococcus virus 37, Staphylococcus virus 53, Staphylococcus virus 55, Staphylococcus virus 69, Staphylococcus virus 71, Staphylococcus virus 80, Staphylococcus virus 85, Staphylococcus virus 88, Staphylococcus virus 92, Staphylococcus virus 96, Staphylococcus virus 187, Staphylococcus virus 52a, Staphylococcus virus 80alpha, Staphylococcus virus CNPH82, Staphylococcus virus EW, Staphylococcus virus IPLA5, Staphylococcus virus IPLA7, Staphylococcus virus IPLA88, Staphylococcus virus PH15, Staphylococcus virus phiETA, Staphylococcus virus phiETA2, Staphylococcus virus phiETA3, Staphylococcus virus phiMR11, Staphylococcus virus phiMR25, Staphylococcus virus phiNM1, Staphylococcus virus phiNM2, Staphylococcus virus phiNM4, Staphylococcus virus SAP26, Staphylococcus virus X2, Enterococcus virus FL1, Enterococcus virus FL2, Enterococcus virus FL3, Lactobacillus virus ATCC8014, Lactobacillus virus phiJL1, Pediococcus virus cIP1, Aeromonas virus pIS4A, Listeria virus LP302, Listeria virus PSA, Methanobacterium virus psiM1, Roseobacter virus RDJL1, Roseobacter virus RDJL2, Rhodococcus virus RER2, Enterococcus virus BC611, Enterococcus virus IMEEF1, Enterococcus virus SAP6, Enterococcus virus VD13, Streptococcus virus SPQS1, Mycobacterium virus Papyrus, Mycobacterium virus Send513, Burkholderia virus KL1, Pseudomonas virus 73, Pseudomonas virus Ab26, Pseudomonas virus Kakheti25, Escherichia virus Cajan, Escherichia virus Seurat, Staphylococcus virus SEP9, Staphylococcus virus Sextaec, Streptococcus virus 858, Streptococcus virus 2972, Streptococcus virus ALQ132, Streptococcus virus 01205, Streptococcus virus Sfi11, Streptococcus virus 7201, Streptococcus virus DT1, Streptococcus virus phiAbc2, Streptococcus virus Sfi19, Streptococcus virus Sfi21, Paenibacillus virus Diva, Paenibacillus virus Hb10c2, Paenibacillus virus Rani, Paenibacillus virus Shelly, Paenibacillus virus Sitara, Paenibacillus virus Willow, Lactococcus virus 712, Lactococcus virus ASCC191, Lactococcus virus ASCC273, Lactococcus virus ASCC281, Lactococcus virus ASCC465, Lactococcus virus ASCC532, Lactococcus virus Bibb29, Lactococcus virus bIL170, Lactococcus virus CB13, Lactococcus virus CB14, Lactococcus virus CB19, Lactococcus virus CB20, Lactococcus virus jj50, Lactococcus virus P2, Lactococcus virus P008, Lactococcus virus ski, Lactococcus virus SI4, Bacillus virus Slash, Bacillus virus Stahl, Bacillus virus Staley, Bacillus virus Stills, Gordonia virus Bachita, Gordonia virus ClubL, Gordonia virus OneUp, Gordonia virus Smoothie, Gordonia virus Soups, Bacillus virus SPbeta, Vibrio virus MAR10, Vibrio virus SSP002, Escherichia virus AKFV33, Escherichia virus BF23, Escherichia virus DT57C, Escherichia virus EPS7, Escherichia virus FFH1, Escherichia virus H8, Escherichia virus slur09, Escherichia virus T5, Salmonella virus 118970sal2, Salmonella virus Shivani, Salmonella virus SPC35, Salmonella virus Stitch, Arthrobacter virus Tank, Tsukamurella virus TIN2, Tsukamurella virus TIN3, Tsukamurella virus TIN4, Rhodobacter virus RcSpartan, Rhodobacter virus RcTitan, Mycobacterium virus Anaya, Mycobacterium virus Angelica, Mycobacterium virus Crimd, Mycobacterium virus Fionnbarth, Mycobacterium virus Jaws, Mycobacterium virus Larva, Mycobacterium virus Macncheese, Mycobacterium virus Pixie, Mycobacterium virus TM4, Bacillus virus BMBtp2, Bacillus virus TP21, Geobacillus virus Tp84, Staphylococcus virus 47, Staphylococcus virus 3a, Staphylococcus virus 42e, Staphylococcus virus IPLA35, Staphylococcus virus phi12, Staphylococcus virus phiSLT, Mycobacterium virus 32HC, Rhodococcus virus RGL3, Paenibacillus virus Vegas, Gordonia virus Vendetta, Bacillus virus Wbeta, Mycobacterium virus Wildcat, Gordonia virus Twister6, Gordonia virus Wizard, Gordonia virus Hotorobo, Gordonia virus Monty, Gordonia virus Woes, Xanthomonas virus CP1, Xanthomonas virus OP1, Xanthomonas virus phiI7, Xanthomonas virus Xop411, Xanthomonas virus Xp10, Streptomyces virus TP1604, Streptomyces virus YDN12, Alphaproteobacteria virus phiJI001, Pseudomonas virus LKO4, Pseudomonas virus M6, Pseudomonas virus MP1412, Pseudomonas virus PAE1, Pseudomonas virus Yua, Pseudoalteromonas virus PM2, Pseudomonas virus phi6, Pseudomonas virus phi8, Pseudomonas virus phi12, Pseudomonas virus phi13, Pseudomonas virus phi2954, Pseudomonas virus phiNN, Pseudomonas virus phiYY, Vibrio virus fs1, Vibrio virus VGJ, Ralstonia virus RS603, Ralstonia virus RSM1, Ralstonia virus RSM3, Escherichia virus M13, Escherichia virus 122, Salmonella virus IKe, Acholeplasma virus L51, Vibrio virus fs2, Vibrio virus VFJ, Escherichia virus If1, Propionibacterium virus B5, Pseudomonas virus Pf1, Pseudomonas virus Pf3, Ralstonia virus PE226, Ralstonia virus RSS1, Spiroplasma virus SVTS2, Stenotrophomonas virus PSH1, Stenotrophomonas virus SMA6, Stenotrophomonas virus SMA7, Stenotrophomonas virus SMA9, Vibrio virus CTXphi, Vibrio virus KSF1, Vibrio virus VCY, Vibrio virus Vf33, Vibrio virus VfO3K6, Xanthomonas virus Cf1c, Spiroplasma virus C74, Spiroplasma virus R8A2B, Spiroplasma virus SkV1CR23x, Escherichia virus FI, Escherichia virus Qbeta, Escherichia virus BZ13, Escherichia virus MS2, Escherichia virus alpha3, Escherichia virus 1D21, Escherichia virus 1D32, Escherichia virus 1D62, Escherichia virus NC28, Escherichia virus NC29, Escherichia virus NC35, Escherichia virus phiK, Escherichia virus St1, Escherichia virus WA45, Escherichia virus G4, Escherichia virus ID52, Escherichia virus Talmos, Escherichia virus phiX174, Bdellovibrio virus MAC1, Bdellovibrio virus MH2K, Chlamydia virus Chp1, Chlamydia virus Chp2, Chlamydia virus CPAR39, Chlamydia virus CPG1, Spiroplasma virus SpV4, Acholeplasma virus L2, Pseudomonas virus PR4, Pseudomonas virus PRD1, Bacillus virus AP50, Bacillus virus Bam35, Bacillus virus GIL16, Bacillus virus Wip1, Escherichia virus phi80, Escherichia virus RB42, Escherichia virus T2, Escherichia virus T3, Escherichia virus T6, Escherichia virus VT2-Sa, Escherichia virus VT1-Sakai, Escherichia virus VT2-Sakai, Escherichia virus CP-933V, Escherichia virus P27, Escherichia virus Stx2phi-I, Escherichia virus Stx1phi, Escherichia virus Stx2phi-II, Escherichia virus CP-1639, based on the Escherichia virus BP-4795, Escherichia virus 86, Escherichia virus Min27, Escherichia virus 2851, Escherichia virus 1717, Escherichia virus YYZ-2008, Escherichia virus EC026_P06, Escherichia virus ECO103_P15, Escherichia virus ECO103_P12, Escherichia virus ECO111_P16, Escherichia virus ECO111_P11, Escherichia virus VT2phi_272, Escherichia virus TL-2011c, Escherichia virus P13374, Escherichia virus Sp5.

In one embodiment, the bacterial virus particles target E. coli and includes the capsid of a bacteriophage selected in the group consisting of BW73, B278, D6, D108, E, EI, E24, E41, F1-2, FI-4, FI-5, H18A, Ff18B, i, MM, Mu, 025, PhI-5, Pk, PSP3, PI, PID, P2, P4, SI, Wφ, φK13, φI, φ2, φ7, φ92, 7 A, 8φ, 9φ, 18, 28-1, 186, 299, HH-Escherichia (2), AB48, CM, C4, C16, DD-VI, E4, E7, E28, FII, FI3, H, HI, H3, H8, K3, M, N, ND-2, ND-3, ND4, ND-5, ND6, ND-7, Ox-I, Ox-2, Ox-3, Ox-4, Ox-5, Ox-6, PhI-I, RB42, RB43, RB49, RB69, S, Sal-I, Sal-2, Sal-3, Sal-4, Sal-5, Sal-6, TC23, TC45, TulI*-6, TulP-24, TulI*46, TulP-60, T2, T4, T6, T35, αI, 1, IA, 3, 3A, 3T+, 5φ, 9266Q, CFO103, HK620, J, K, KIF, m59, no. A, no. E, no. 3, no. 9, N4, sd, T3, T7, WPK, W31, ΔH, φC3888, φK3, φK7, φK12, φV-1, ϕ04-CF, ϕ05, ϕ06, ϕ07, φI, φI.2, φ20, φ95, φ263, φIO92, φI, φII, Ω8, 1, 3, 7, 8, 26, 27, 28-2, 29, 30, 31, 32, 38, 39, 42, 933W, NN-Escherichia (1), Esc-7-11, AC30, CVX-5, CI, DDUP, ECI, EC2, E21, E29, FI, F26S, F27S, Hi, HK022, HK97, HK139, HK253, HK256, K7, ND-I, PA-2, q, S2, TI), T3C, T5, UC-I, w, β4, γ2, λ, ϕD326, φγ, ϕ06, ϕ7, ϕ10, φ80, χ, 2, 4, 4A, 6, 8A, 102, 150, 168, 174, 3000, AC6, AC7, AC28, AC43, AC50, AC57, AC81, AC95, HK243, KIO, ZG/3A, 5, 5A, 21EL, H19-J and 933H.

In some embodiment the vectors disclosed herein may be used in combination with prebiotics. Prebiotics include, but are not limited to, amino acids, biotin, fructo-oligosaccharide, galacto-oligosaccharides, hemicelluloses (e.g., arabinoxylan, xylan, xyloglucan, and glucomannan), inulin, chitin, lactulose, mannan oligosaccharides, oligofructose-enriched inulin, gums (e.g., guar gum, gum arabic and carrageenan), oligofructose, oligodextrose, tagatose, resistant maltodextrins (e.g., resistant starch), trans-galactooligosaccharide, pectins (e.g., xylogalactouronan, citrus pectin, apple pectin, and rhamnogalacturonan-I), dietary fibers (e.g., soy fiber, sugarbeet fiber, pea fiber, corn bran, and oat fiber) and xylooligosaccharides.

In other embodiment, the vectors disclosed herein may be used in combination with probiotics. Probiotics include, but are not limited to lactobacilli, bifidobacteria, streptococci, enterococci, propionibacteria, saccaromycetes, lactobacilli, bifidobacteria, or proteobacteria.

Screening Methods

The invention encompasses methods for screening for genetic modifications in bacteria. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting a bacterial sample from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest.

In one embodiment, the proportion of endogenous modified vs non-modified bacteria is quantified. Preferred percentages of bacteria with the genetic modification are at least 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 97%, 98%, 99%, 99.9%, 99.99%, and 100%.

In one embodiment, the number of non-modified endogenous bacteria is quantified prior to administering a vector. The patient can also be pre-screened to determine the genetic signature of the strains the patient carries. This will allow selection of an appropriate capsid to deliver the therapeutic payload based on the genetic signature of the strains the patient carry.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial sample can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc.

The level of bacteria containing or not containing a genetic modification in a base of a DNA of interest can be determined by any technique known to the skilled artisan, such as routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

The invention encompasses methods for determining the efficiency of a vector at inducing genetic mutations in situ. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting a bacterial sample from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial sample can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc.

The level of bacteria containing or not containing a genetic modification in a base of a DNA of interest can be determined by any technique known to the skilled artisan, such as routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

The invention encompasses methods for determining the effect of a genetic mutation on bacterial growth. In one embodiment, the method comprises administering a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria, to a subject, subsequently collecting at least two sequential bacterial samples from the subject, quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest in said bacterial samples.

In preferred embodiments, the vector is in a pharmaceutical and veterinary composition. Preferably the vector is a bacteriophage.

The vector can be administered to the subject by any administration technique known in the art, depending on the vector and the target bacteria's expected location in or on the subject.

The bacterial samples can be collected by any means known in the art, such as biopsy, blood draw, urine sample, stool sample, or oral/nasal swab, etc. The samples can be collected at any sequential time points. Preferably, the time between these collections is at least 3, 6, 12, 24, 48, 72, 96 hrs or 7, 14, 30, 60, 120, or 365 days.

The level of bacteria containing or not containing a genetic modification in a base of a DNA of interest can be determined by any technique known to the skilled artisan, such as routine diagnostic procedures including ELISA, PCR, High Resolution Melting, and nucleic acid sequencing.

All of the screening methods of the invention can use any of the vectors and enzymes/systems of the invention to screen for any of the genetic modification of the invention.

All of the screening methods of the invention can further include a step of comparing the level of bacteria containing a genetic modification in a base of a DNA of interest with the level of bacteria not containing a genetic modification the base of a DNA of interest in a bacterial sample.

All of the screening methods of the invention can further include a step of contacting the vector with bacteria in liquid or solid culture and quantifying the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest.

In one embodiment, the method comprises providing a vector designed to genetically modify at least one base of a DNA of interest in a gene of a naturally occurring bacteria. The method can further comprise contacting the vector with bacteria in liquid or solid culture and quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA of interest in said bacterial sample. The method can further comprise quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA of interest. The levels of bacteria containing a genetic modification in a base of a DNA of interest can be compared with the level of bacteria not containing a genetic modification the base of a DNA of interest over time in the culture. Preferably, the time between these comparisons is at least 1, 2, 3, 4, 5, 6, 12, 24, 48, 72, or 96 hours.

Pharmaceutical and Veterinary Compositions and In Situ Administration Methods

The invention encompasses pharmaceutical and veterinary compositions comprising the vectors of the invention.

The invention encompasses in situ administration of the pharmaceutical or veterinary composition to the bacteria in a subject. Any method known to the skilled artisan can be used to contact the vector with the bacterial target in situ.

The pharmaceutical or veterinary composition according to the invention may further comprise a pharmaceutically acceptable vehicle. A solid pharmaceutically acceptable vehicle may include one or more substances which may also act as flavoring agents, lubricants, solubilisers, suspending agents, dyes, fillers, glidants, compression aids, inert binders, sweeteners, preservatives, dyes, coatings, or tablet-disintegrating agents. Suitable solid vehicles include, for example calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, polyvinylpyrrolidone, low melting waxes and ion exchange resins.

The pharmaceutical or veterinary composition may be prepared as a sterile solid composition that may be suspended at the time of administration using sterile water, saline, or other appropriate sterile injectable medium. The pharmaceutical or veterinary compositions of the invention may be administered orally in the form of a sterile solution or suspension containing other solutes or suspending agents (for example, enough saline or glucose to make the solution isotonic), bile salts, acacia, gelatin, sorbitan monoleate, polysorbate 80 (oleate esters of sorbitol and its anhydrides copolymerized with ethylene oxide) and the like. The particles according to the invention can also be administered orally either in liquid or solid composition form. Compositions suitable for oral administration include solid forms, such as pills, capsules, granules, tablets, and powders, and liquid forms, such as solutions, syrups, elixirs, and suspensions. Forms useful for enteral administration include sterile solutions, emulsions, and suspensions.

The bacterial virus particles according to the invention may be dissolved or suspended in a pharmaceutically acceptable liquid vehicle such as water, an organic solvent, a mixture of both or pharmaceutically acceptable oils or fats. The liquid vehicle can contain other suitable pharmaceutical additives such as solubilisers, emulsifiers, buffers, preservatives, sweeteners, flavouring agents, suspending agents, thickening agents, colours, viscosity regulators, stabilizers or osmo-regulators. Suitable examples of liquid vehicles for oral and enteral administration include water (partially containing additives as above, e.g. cellulose derivatives, preferably sodium carboxymethyl cellulose solution), alcohols (including monohydric alcohols and polyhydric alcohols, e.g. glycols) and their derivatives, and oils (e.g. fractionated coconut oil and arachis oil). For parenteral administration, the vehicle can also be an oily ester such as ethyl oleate and isopropyl myristate. Sterile liquid vehicles are useful in sterile liquid form compositions for enteral administration. The liquid vehicle for pressurized compositions can be a halogenated hydrocarbon or other pharmaceutically acceptable propellant.

In some embodiments, the invention encompasses pharmaceutical or veterinary composition formulated for delayed or gradual enteric release. In preferred embodiments, formulations or pharmaceutical preparations of the invention are formulated for delivery of the vector into the distal small bowel and/or the colon. The formulation can allow the vector to pass through stomach acid and pancreatic enzymes and bile, and reach undamaged to be viable in the distal small bowel and colon.

In some embodiments, the pharmaceutical or veterinary composition is micro-encapsulated, formed into tablets and/or placed into capsules, preferably enteric-coated capsules.

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release, using cellulose acetate (CA) and polyethylene glycol (PEG). In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using a hydroxypropylmethylcellulose (HPMC), a microcrystalline cellulose (MCC) and magnesium stearate. the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using e.g., a poly(meth)acrylate, e.g. a methacrylic acid copolymer B, a methyl methacrylate and/or a methacrylic acid ester, or a polyvinylpyrrolidone (PVP).

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release using a release-retarding matrix material such as: an acrylic polymer, a cellulose, a wax, a fatty acid, shellac, zein, hydrogenated vegetable oil, hydrogenated castor oil, polyvinylpyrrolidone, a vinyl acetate copolymer, a vinyl alcohol copolymer, polyethylene oxide, an acrylic acid and methacrylic acid copolymer, a methyl methacrylate copolymer, an ethoxyethyl methacrylate polymer, a cyanoethyl methacrylate polymer, an aminoalkyl methacrylate copolymer, a poly(acrylic acid), a poly(methacrylic acid), a methacrylic acid alkylamide copolymer, a poly(methyl methacrylate), a poly(methacrylic acid anhydride), a methyl methacrylate polymer, a polymethacrylate, a poly(methyl methacrylate) copolymer, a polyacrylamide, an aminoalkyl methacrylate copolymer, a glycidyl methacrylate copolymer, a methyl cellulose, an ethylcellulose, a carboxymethylcellulose, a hydroxypropylmethylcellulose, a hydroxymethyl cellulose, a hydroxyethyl cellulose, a hydroxypropyl cellulose, a crosslinked sodium carboxymethylcellulose, a crosslinked hydroxypropylcellulose, a natural wax, a synthetic wax, a fatty alcohol, a fatty acid, a fatty acid ester, a fatty acid glyceride, a hydrogenated fat, a hydrocarbon wax, stearic acid, stearyl alcohol, beeswax, glycowax, castor wax, carnauba wax, a polylactic acid, polyglycolic acid, a co-polymer of lactic and glycolic acid, carboxymethyl starch, potassium methacrylate/divinylbenzene copolymer, crosslinked polyvinylpyrrolidone, polyvinylalcohols, polyvinylalcohol copolymers, polyethylene glycols, non-crosslinked polyvinylpyrrolidone, polyvinyl acetates, polyvinylacetate copolymers or any combination thereof.

In some embodiments, the pharmaceutical or veterinary compositions are formulated for delayed or gradual enteric release as described in U.S. Pat. App. Pub. 20110218216, which describes an extended release pharmaceutical composition for oral administration, and uses a hydrophilic polymer, a hydrophobic material and a hydrophobic polymer or a mixture thereof, with a microenvironment pH modifier. The hydrophobic polymer can be ethylcellulose, cellulose acetate, cellulose propionate, cellulose butyrate, methacrylic acid-acrylic acid copolymers or a mixture thereof. The hydrophilic polymer can be polyvinylpyrrolidone, hydroxypropylcellulose, methylcellulose, hydroxypropylmethyl cellulose, polyethylene oxide, acrylic acid copolymers or a mixture thereof. The hydrophobic material can be a hydrogenated vegetable oil, hydrogenated castor oil, carnauba wax, candellia wax, beeswax, paraffin wax, stearic acid, glyceryl behenate, cetyl alcohol, cetostearyl alcohol or and a mixture thereof. The microenvironment pH modifier can be an inorganic acid, an amino acid, an organic acid or a mixture thereof. Alternatively, the microenvironment pH modifier can be lauric acid, myristic acid, acetic acid, benzoic acid, palmitic acid, stearic acid, oxalic acid, malonic acid, succinic acid, adipic acid, sebacic acid, fumaric acid, maleic acid; glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, sodium dihydrogen citrate, gluconic acid, a salicylic acid, tosylic acid, mesylic acid or malic acid or a mixture thereof.

In some embodiments, the pharmaceutical or veterinary compositions are a powder that can be included into a tablet or a suppository. In alternative embodiments, a formulation or pharmaceutical preparation of the invention can be a ‘powder for reconstitution’ as a liquid to be drunk or otherwise administered.

In some embodiments, the pharmaceutical or veterinary compositions can be administered in a cream, gel, lotion, liquid, feed, or aerosol spray. In some embodiments, a bacteriophage is immobilized to a solid surface using any substance known in the art and any technology known in the art, for example, but not limited to immobilization of bacteriophages onto polymeric beads using technology as outlined in U.S. Pat. No. 7,482,115, which is incorporated herein by reference. Phages may be immobilized onto appropriately sized polymeric beads so that the coated beads may be added to aerosols, creams, gels or liquids. The size of the polymeric beads may be from about 0.1 μm to 500 μm, for example 50 pm to 100 μm. The coated polymeric beads may be incorporated into animal feed, including pelleted feed and feed in any other format, incorporated into any other edible device used to present phage to the animals, added to water offered to animals in a bowl, presented to animals through water feeding systems. In some embodiments, the compositions are used for treatment of surface wounds and other surface infections using creams, gels, aerosol sprays and the like.

In some embodiments, the pharmaceutical or veterinary compositions can be administered by inhalation, in the form of a suppository or pessary, topically (e.g., in the form of a lotion, solution, cream, ointment or dusting powder), epi- or transdermally (e.g., by use of a skin patch), orally (e.g., as a tablet, which may contain excipients such as starch or lactose), as a capsule, ovule, elixirs, solutions, or suspensions (each optionally containing flavoring, coloring agents and/or excipients), or they can be injected parenterally (e.g., intravenously, intramuscularly or subcutaneously). For parenteral administration, the compositions may be used in the form of a sterile aqueous solution which may contain other substances, for example enough salts or monosaccharides to make the solution isotonic with blood. For buccal or sublingual administration the compositions may be administered in the form of tablets or lozenges which can be formulated in a conventional manner. In a preferred embodiment, a bacteriophage and/or polypeptide of the present invention is administered topically, either as a single agent, or in combination with other antibiotic treatments, as described herein or known in the art.

In some embodiments, the pharmaceutical or veterinary compositions can also be dermally or transdermally administered. For topical application to the skin, the pharmaceutical or veterinary composition can be combined with one or a combination of carriers, which can include but are not limited to, an aqueous liquid, an alcohol base liquid, a water soluble gel, a lotion, an ointment, a nonaqueous liquid base, a mineral oil base, a blend of mineral oil and petrolatum, lanolin, liposomes, proteins carriers such as serum albumin or gelatin, powdered cellulose carmel, and combinations thereof. A topical mode of delivery may include a smear, a spray, a bandage, a time-release patch, a liquid-absorbed wipe, and combinations thereof. The pharmaceutical or veterinary composition can be applied to a patch, wipe, bandage, etc., either directly or in a carrier(s). The patches, wipes, bandages, etc., may be damp or dry, wherein the phage and/or polypeptide (e.g., a lysin) is in a lyophilized form on the patch. The carriers of topical compositions may comprise semi-solid and gel-like vehicles that include a polymer thickener, water, preservatives, active surfactants, or emulsifiers, antioxidants, sun screens, and a solvent or mixed solvent system. U.S. Pat. No. 5,863,560 discloses a number of different carrier combinations that can aid in the exposure of skin to a medicament, and its contents are incorporated herein.

For intranasal or administration by inhalation, the pharmaceutical or veterinary composition is conveniently delivered in the form of a dry powder inhaler or an aerosol spray presentation from a pressurized container, pump, spray, or nebuliser with the use of a suitable propellant, e.g., dichlorodifluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, a hydrofluoroalkane such as 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane, carbon dioxide, or other suitable gas. In the case of a pressurized aerosol, the dosage unit may be determined by providing a valve to deliver a metered amount. The pressurized container, pump, spray, or nebuliser may contain a solution or suspension of the active compound, e.g., using a mixture of ethanol and the propellant as the solvent, which may additionally contain a lubricant, e.g., sorbitan trioleate. Capsules and cartridges (made, for example, from gelatin) for use in an inhaler or insufflator may be formulated to contain a powder mix of the bacteriophage and/or polypeptide of the invention and a suitable powder base such as lactose or starch.

For administration in the form of a suppository or pessary, the pharmaceutical or veterinary composition can be applied topically in the form of a gel, hydrogel, lotion, solution, cream, ointment, or dusting powder. Compositions of the invention may also be administered by the ocular route. For ophthalmic use, the compositions of the invention can be formulated as micronized suspensions in isotonic, pH adjusted, sterile saline, or, preferably, as solutions in isotonic, pH adjusted, sterile saline, optionally in combination with a preservative such as a benzylalkonium chloride. Alternatively, they may be formulated in an ointment such as petrolatum.

Dosages and desired drug concentrations of the pharmaceutical and veterinary composition compositions of the present invention may vary depending on the particular use. The determination of the appropriate dosage or route of administration is within the skill of an ordinary physician. Animal experiments can provide reliable guidance for the determination of effective doses in human therapy.

For transdermal administration, the pharmaceutical or veterinary composition can be formulated into ointment, cream or gel form and appropriate penetrants or detergents could be used to facilitate permeation, such as dimethyl sulfoxide, dimethylacetamide and dimethylformamide.

For transmucosal administration, nasal sprays, rectal or vaginal suppositories can be used. The active compounds can be incorporated into any of the known suppository bases by methods known in the art. Examples of such bases include cocoa butter, polyethylene glycols (carbowaxes), polyethylene sorbitan monostearate, and mixtures of these with other compatible materials to modify the melting point or dissolution rate.

Disease Treatment

The invention encompasses the treatment of diseases and metabolic disorders caused by bacteria. The diseases or disorders caused by bacteria may be selected from the group consisting of skin chronic inflammation such as acne (acne vulgaris), progressive macular hypomelanosis, abdominal cramps, acute epiglottitis, arthritis, bacteraemia, bloody diarrhea, botulism, Brucellosis, brain abscess, cardiomyopathy, chancroid venereal disease, Chlamydia, Crohn's disease, conjunctivitis, cholecystitis, colorectal cancer, polyposis, dysbiosis, Lyme disease, diarrhea, diphtheria, duodenal ulcers, endocarditis, erysipelothricosis, enteric fever, fever, glomerulonephritis, gastroenteritis, gastric ulcers, Guillain-Barre syndrome tetanus, gonorrhoea, gingivitis, inflammatory bowel diseases, irritable bowel syndrome, leptospirosis, leprosy, listeriosis, tuberculosis, Lady Widermere syndrome, Legionaire's disease, meningitis, mucopurulent conjunctivitis, multi-drug resistant bacterial infections, multi-drug resistant bacterial carriage, myocarditis, myonecrosis-gas gangrene, Mycobacterium avium complex, neonatal necrotizing enterocolitis, nocardiosis, nosocomial infection, otitis, periodontitis, phalyngitis, pneumonia, peritonitis, purpuric fever, Rocky Mountain spotted fever, shigellosis, syphilis, sinusitis, sigmoiditis, septicaemia, subcutaneous abscesses, tularaemia, tracheobronchitis, tonsillitis, typhoid fever, ulcerative colitis, urinary infection, whooping cough, Nonalcoholic Fatty Liver Disease (NAFLD), Nonalcoholic steatohepatitis (NASH).

The infection caused by bacteria may be selected from the group consisting of infections, preferably intestinal infections such as esophagitis, gastritis, enteritis, colitis, sigmoiditis, rectitis, and peritonitis, urinary tract infections, vaginal infections, female upper genital tract infections such as salpingitis, endometritis, oophoritis, myometritis, parametritis and infection in the pelvic peritoneum, respiratory tract infections such as pneumonia, intra-amniotic infections, odontogenic infections, endodontic infections, fibrosis, meningitis, bloodstream infections, nosocomial infection such as catheter-related infections, hospital acquired pneumonia, post-partum infection, hospital acquired gastroenteritis, hospital acquired urinary tract infections, or a combination thereof. Preferably, the infection according to the invention is caused by a bacterium presenting an antibiotic resistance. In a particular embodiment, the infection is caused by a bacterium as listed above in the targeted bacteria.

The disclosure also concerns a pharmaceutical or veterinary composition of the invention for the treatment of a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease. Indeed, emerging evidence indicates that these disorders are characterized by alterations in the intestinal microbiota composition and its metabolites (Tilg et al., Nature Reviews Immunology, volume 20, pages 40-54, 2020). The pharmaceutical or veterinary composition may thus be used to deliver in some intestinal bacteria a nucleic acid of interest which can alter the intestinal microbiota composition or its metabolites (e.g. by inducing expression, overexpression or secretion of some molecules by said bacteria, for example molecules having a beneficial role on metabolic inflammation). The disclosure also concerns the use of a pharmaceutical or veterinary composition of the invention for the manufacture of a medicament for the treatment of a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease. It also relates to a method for treating a metabolic disorder including, for example, obesity, type 2 diabetes and nonalcoholic fatty liver disease, comprising administering to a subject having a metabolic disorder in need of treatment the provided pharmaceutical or veterinary composition, in particular a therapeutically effective amount of the provided pharmaceutical or veterinary composition.

In a particular embodiment, the invention concerns a pharmaceutical or veterinary composition for use in the treatment of pathologies involving bacteria of the human microbiome, such as inflammatory and auto-immune diseases, cancers, infections or brain disorders. Indeed, some bacteria of the microbiome, without triggering any infection, can secrete molecules that will induce and/or enhance inflammatory or auto-immune diseases or cancer development. More specifically, the present invention relates also to modulating microbiome composition to improve the efficacy of immunotherapies based, for example, on CAR-T (Chimeric Antigen Receptor T) cells, TIL (Tumor Infiltrating Lymphocytes) and Tregs (Regulatory T cells) also known as suppressor T cells. Modulation of the microbiome composition to improve the efficacy of immunotherapies may also include the use of immune checkpoint inhibitors well known in the art such as, without limitation, PD-1 (programmed cell death protein 1) inhibitor, PD-L1 (programmed death ligand 1) inhibitor and CTLA-4 (cytotoxic T lymphocyte associated protein 4).

Some bacteria of the microbiome can also secrete molecules that will affect the brain.

Therefore, a further object of the invention is a method, in particular a non-therapeutic method, for controlling the microbiome of a subject, comprising administering an effective amount of the pharmaceutical composition as disclosed herein in said subject. A further object of the invention is the pharmaceutical composition of the invention further use for controlling the microbiome of a subject.

In a particular embodiment, the invention also relates to a method for personalized treatment for an individual in need of treatment for a bacterial infection comprising: i) obtaining a biological sample from the individual and determining a group of bacterial DNA sequences from the sample; ii) based on the determining of the sequences, identifying one or more pathogenic bacterial strains or species that were in the sample; and iii) administering to the individual a pharmaceutical composition according to the invention capable of recognizing each pathogenic bacterial strain or species identified in the sample and to deliver the packaged payload. The present invention also concerns a pharmaceutical composition of the invention for use in a method for personalized treatment for an individual in need of treatment for a bacterial infection, said method comprising: i) obtaining a biological sample from the individual and determining a group of bacterial DNA sequences from the sample; ii) based on the determining of the sequences, identifying one or more pathogenic bacterial strains or species that were in the sample; and wherein the pharmaceutical composition is capable of recognizing each pathogenic bacterial strain or species identified in the sample and to deliver the packaged plasmid.

Preferably, the biological sample comprises pathological and non-pathological bacterial species, and subsequent to administering the pharmaceutical or veterinary composition according to the invention to the individual, the amount of pathogenic bacteria on or in the individual are reduced, but the amount of non-pathogenic bacteria is not reduced.

In another particular embodiment, the invention concerns a pharmaceutical or veterinary composition according to the invention for use in order to improve the effectiveness of drugs. Indeed, some bacteria of the microbiome, without being pathogenic by themselves, are known to be able to metabolize drugs and to modify them in ineffective or harmful molecules.

In another particular embodiment, the invention concerns the in-situ bacterial production of any compound of interest, including therapeutic compound such as prophylactic and therapeutic vaccine for mammals. The compound of interest can be produced inside the targeted bacteria, secreted from the targeted bacteria or expressed on the surface of the targeted bacteria. In a more particular embodiment, an antigen is expressed on the surface of the targeted bacteria for prophylactic and/or therapeutic vaccination.

Method for Counter-Selection In Situ

In a particular embodiment, the vector encodes a DNA modifying enzyme, in particular a programmed nuclease, that can discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of the targeted bacteria in which the modification has not occurred.

In a particular embodiment, the nuclease can be a RNA-guided nuclease.

In a particular embodiment, the design of the vector increases the chances that the killing effect mediated by said programmed nuclease is delayed, thereby providing enough time for the target DNA sequence to be edited by the base-editing or prime-editing enzyme/system.

The invention also provides compositions and methods to ensure a robust alteration of all targeted bacteria within a microbiome population, thanks to the delivery of a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. In a particular embodiment, the vector of the invention is thus used in combination with a nucleic acid encoding a nuclease programmed to discriminate between targeted bacteria that have been genetically modified in situ and targeted bacteria in which the modification has not occurred, leading to the specific killing of those in which the modification has not occurred. In a particular embodiment, the delivery of such a programmed nuclease is either on the same vector as the one carrying the base-editing nuclease, or on a different vector. In a particular embodiment, the delivery of such programmed nuclease is implemented either simultaneously or after the vector encoding the base-editing nuclease. If delivered simultaneously, the vector can be engineered to have a delayed targeting process for the programmed nuclease leading to a double strand break.

Non-Therapeutic Uses

The present invention also relates to a non-therapeutic use of the bacterial delivery particles of the invention. For instance, the non-therapeutic use can be a cosmetic use or a use for improving the well-being of a subject, in particular a subject who does not suffer from a disease. Accordingly, the present invention also relates to a cosmetic composition or a non-therapeutic composition comprising the bacterial delivery particles of the invention.

Subject, Regimen and Administration

The subject according to the invention is an animal, preferably a mammal, even more preferably a human. However, the term “subject” can also refer to non-human animals, in particular mammals such as dogs, cats, horses, cows, pigs, sheep, donkeys, rabbits, ferrets, gerbils, hamsters, chinchillas, rats, mice, guinea pigs and non-human primates, among others, or non-mammals such as poultry, that are in need of treatment.

The human subject according to the invention may be a human at the prenatal stage, a new-born, a child, an infant, an adolescent or an adult at any age.

In a preferred embodiment, the subject has been diagnosed with, or is at risk of developing an infection, a disorder and/or a disease preferably due to a bacterium. Diagnostic methods of such infection, disorder and/or disease are well known by the man skilled in the art.

In a particular embodiment, the infection, disorder and/or disease presents a resistance to treatment, preferably the infection, disorder or disease presents an antibiotic resistance.

In a particular embodiment, the subject has never received any treatment prior to the administration of the delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention.

In a particular embodiment, the subject has already received at least one line of treatment, preferably several lines of treatment, prior to the administration of the delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention.

Preferably, the treatment is administered regularly, preferably between every day and every month, more preferably between every day and every two weeks, more preferably between every day and every week, even more preferably the treatment is administered every day. In a particular embodiment, the treatment is administered several times a day, preferably 2 or 3 times a day, even more preferably 3 times a day.

The duration of treatment with delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or with a pharmaceutical or veterinary composition according to the invention, is preferably comprised between 1 day and 20 weeks, more preferably between 1 day and 10 weeks, still more preferably between 1 day and 4 weeks, even more preferably between 1 day and 2 weeks. In a particular embodiment, the duration of the treatment is about 1 week. Alternatively, the treatment may last as long as the infection, disorder and/or disease persists.

The form of the pharmaceutical or veterinary compositions, the route of administration and the dose of administration of delivery vehicles according to the invention, preferably of a vector according to the invention, particularly of a payload packaged into a delivery vehicle according to the invention, preferably of a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention can be adjusted by the man skilled in the art according to the type and severity of the infection (e.g. depending on the bacteria species involved in the disease, disorder and/or infection and its localization in the patient's or subject's body), and to the patient or subject, in particular its age, weight, sex, and general physical condition.

Particularly, the amount of delivery vehicles according to the invention, preferably a vector according to the invention, particularly a payload packaged into a delivery vehicle according to the invention, preferably a packaged plasmid or phagemid into a bacterial virus particle according to the invention, or of a pharmaceutical or veterinary composition according to the invention, to be administered has to be determined by standard procedure well known by those of ordinary skills in the art. Physiological data of the patient or subject (e.g. age, size, and weight) and the routes of administration have to be taken into account to determine the appropriate dosage, so as a therapeutically effective amount will be administered to the patient or subject.

For example, the total amount of delivery vehicles, particularly a payload packaged into a delivery vehicle according to the invention, preferably a plasmid or phagemid packaged into a bacterial virus particle according to the invention, for each administration is comprised between 10¹⁴ and 10¹⁵ delivery vehicles.

The present invention further concerns the following embodiments:

1. A method of modifying a naturally occurring bacteria in situ comprising:

genetically modifying a DNA sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence, wherein said genetic modification does not lead to the death of bacteria.

2. The method according to embodiment 1, comprising contacting said naturally occurring bacteria with a vector.

3. The method according to embodiment 1, comprising contacting said naturally occurring bacteria with a vector located inside a delivery vehicle.

4. The method according to embodiment 3, wherein said vector located inside a delivery vehicle is a phagemid.

5. The method according to embodiment 1, comprising transducing said naturally occurring bacteria with a packaged phagemid.

6. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 (dead-Cas9) or nCas9 (nickase Cas9).

7. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 and a deaminase domain, or a nCas9 and deaminase domain.

8. The method according to embodiment 4 or 5, wherein said phagemid comprises a nucleic acid sequence encoding a dCas9 and a reverse transcriptase domain, or a nCas9 and a reverse transcriptase domain.

9. The method according to any of embodiments 2 to 8, wherein the vector or phagemid further comprises a conditional origin of replication which is inactive in the targeted naturally occurring bacteria but is active in a donor bacterial cell.

10. The method according to embodiment 9, wherein said conditional origin of replication is an origin of replication, the replication of which depends upon the presence of a given protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

11. The method according to embodiment 10, wherein said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses said given protein, peptid, nucleic acid, RNA, molecule or any combination thereof.

12. The method according to any of embodiments 9-11, wherein said conditional origin of replication is an origin of replication derived from phage-inducible chromosomal islands (PICIs).

13. The method according to embodiment 12, wherein said conditional origin of replication is active in said donor bacterial cell because said donor bacterial cell expresses a rep protein, in particular a primase-helicase.

14. The method according to embodiment 12 or 13, wherein said conditional origin of replication is derived from the origin of replication from the PICI of the Escherichia coli strain CFT073.

15. The method according to embodiment 14, wherein said conditional origin of replication comprises or consists of the sequence SEQ ID NO: 7 or SEQ ID NO: 8.

16. The method according to any of embodiments 1-15, wherein said genetic modification is a point mutation.

17. The method according to any of embodiments 1-16, wherein said genetic modification is a point mutation leading to gene disruption.

18. The method according to any of embodiments 1-17, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

19. The method according to any of embodiments 1-18, wherein the genetic modification is in a bacterial toxin gene.

20. The method according to embodiment 19, comprising a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. 21. The method according to embodiment 20, comprising a genetic modification at S95 or K98 of the ClbP gene. 22. The method according to embodiment 21, comprising a genetic modification of S95A, S95R or K98T. 23. The method according to any of embodiments 1-18, wherein the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene. 24. The method according to embodiment 16, wherein the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein with the genetic modification shows lower homology with human MYH6 cardiac peptide as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification. 25. The method according to any of embodiments 1-18, wherein the genetic modification is in Propionibacterium propionicum Ro60 orthologs. 26. The method according to embodiment 25, wherein the genetic modification is in at least one Propionibacterium propionicum Ro60 ortholog epitope leading to weaker or no recognition by the human immune system. 27. The method according to any of embodiments 1-26, comprising genetically modifying at least one gene in the naturally occurring bacteria in situ in a human. 28. A method of modulating host-microbiome interaction by genetically modifying naturally occurring bacteria in situ wherein said naturally occurring bacteria is involved in microbiome associated disorder or disease comprising:

genetically modifying a DNA sequence responsible for the microbiome associated disorder or disease in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence,

wherein said genetic modification reduces the effects of the microbiome associated disorder or disease, and

wherein said genetic modification does not lead to the death of bacteria.

29. The method according to embodiment 28, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

30. A method to prevent or intervene in the course of an auto-immune disease/reaction in a predisposed host by modifying the immunogenic profile of a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the gene coding for the immunogenic component results in loss of its immunogenic component;

wherein genetic modification does not lead to the direct death of the bacteria.

31. The method according to embodiment 30, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.

32. The method according to embodiment 30 comprising contacting said bacteria with a phagemid encoding an enzyme that modifies the genome of said bacteria.

33. The method according to embodiment 30, comprising contacting said bacteria with a phagemid encoding an enzyme that is a base-editor.

34. The method according to embodiment 30, comprising contacting said bacteria with a phagemid encoding an enzyme that is a prime-editor.

35. The method according to any of embodiments 28 or 30, wherein the genetic modification is a point mutation that results in a change of amino-acid in a mimic peptide and renders the mimic peptide not immunogenic and/or not recognized by the immune system. 36. The method according to embodiment 28, wherein the genetic modification results in a change of sugar profile on the bacterial membrane. 37. The method according to embodiment 28, wherein the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of sugar profile on the bacterial membrane. 38. The method according to embodiment 28, wherein the genetic modification results in a change of lipid profile on the bacterial membrane. 39. The method according to embodiment 28, wherein the genetic modification results in a change of amino acid in a protein sequence that in turn results in a change of lipid profile on the bacterial membrane. 40. The method according to any of embodiments 1-30, wherein the genetic modification renders a catalytic site inactive. 41. The method according to any of embodiments 1-30, wherein the genetic modification renders a binding site with a human cell receptor non-functional. 42. The method according to any of embodiments 1-30, wherein the genetic modification renders the bacteria more sensitive to detection by human immune cells. 43. A method for screening for genetic modifications in bacteria comprising:

administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene of a naturally occurring bacteria without introducing a double strand break in the DNA sequence,

subsequently collecting a bacterial sample from the subject, and

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

44. The method according to embodiment 43, further comprising quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest.

45. A method for determining the efficiency of a vector at inducing genetic mutations in situ comprising:

administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene of a naturally occurring bacteria without introducing a double strand break in the DNA sequence,

subsequently collecting a bacterial sample from the subject,

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest, and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial sample.

46. A method for determining the effect of a genetic mutation on bacterial growth comprising:

administering, to a subject, a vector designed to genetically modify at least one base of a DNA sequence of interest in a gene of a naturally occurring bacteria, without introducing a double strand break in the DNA sequence,

subsequently collecting at least two sequential bacterial samples from the subject,

quantitating the level of bacteria containing a genetic modification in said at least one base of a DNA sequence of interest and quantitating the level of bacteria not containing a genetic modification in said at least one base of a DNA sequence of interest in said bacterial samples.

47. The method according to any of embodiments 43 to 46, comprising a genetic modification of the ClbP gene in pks+ E. coli that results in a single-amino acid mutation and the inactivation of the genotoxic activity of Colibactin toxin, but maintains the antagonistic activity. 48. An engineered bacteriophage for modifying a naturally occurring bacteria in situ comprising a nucleic acid encoding a gene editing enzyme/system for transformation of a target bacteria in a mixed bacterial population wherein said gene editing enzyme/system modifies the genome of said target bacteria without introducing a double strand break in the DNA sequence, but does not lead to the death of the target bacteria. 49. The bacteriophage according to embodiment 48 for use for treating a disease or disorder, wherein the gene editing enzyme/system targets a gene within the target bacteria encoding a protein which is directly or indirectly responsible for said disease or disorder. 50. A method to modify the metabolism of a given drug in a host treated with said drug, by modifying at least one drug-targeting enzyme expressed by a bacterial population of the host microbiome, comprising:

contacting the bacterial population with a vector that generates a genetic modification in a DNA sequence coding for a drug-targeting enzyme expressed or secreted by the bacteria in at least some of the bacteria of said population without introducing a double strand break in the DNA sequence,

wherein the genetic modification of the DNA sequence coding for the drug-targeting enzyme results in a modification of the drug metabolism in the host;

wherein genetic modification does not lead to the direct death of the bacteria.

Definitions

«vector»

As used herein, the term “vector” refers to any construct of sequences that are capable of expression of a polypeptide in a given host cell. If a vector is used then the choice of vector is dependent upon the method that will be used to transform host bacteria as is well known to those skilled in the art. Vectors can include, without limitation, plasmid vectors and recombinant phage vectors, or any other vector known in that art suitable for delivering a polypeptide of the invention to target bacteria. The skilled artisan is well aware of the genetic elements that must be present on the vector in order to successfully transform, select and propagate host cells comprising any of the isolated nucleotides or nucleic acid sequences of the invention.

«delivery vehicle»

As used herein, the term «delivery vehicle» refers to any vehicle that allows the transfer of a payload or vector into a bacterium.

There are several types of delivery vehicle encompassed by the present invention including, without limitation, bacteriophage scaffold, virus scaffold, bacterial virus particle, chemical based delivery vehicle (e.g., cyclodextrin, calcium phosphate, cationic polymers, cationic liposomes), protein-based or peptide-based delivery vehicle, lipid-based delivery vehicle, nanoparticle-based delivery vehicles, non-chemical-based delivery vehicles (e.g., transformation, electroporation, sonoporation, optical transfection), particle-based delivery vehicles (e.g., gene gun, magnetofection, impalefection, particle bombardment, cell-penetrating peptides) or donor bacteria (conjugation).

Any combination of delivery vehicles is also encompassed by the present invention.

The delivery vehicle can refer to a bacteriophage derived scaffold and can be obtained from a natural, evolved or engineered capsid.

In some embodiment, the delivery vehicle is the payload or vector as bacteria are naturally competent to take up a payload or vector from the environment on their own.

«payload

As used herein, the term «payload» refers to any nucleic acid sequence or amino acid sequence, or a combination of both (such as, without limitation, peptide nucleic acid or peptide-oligonucleotide conjugate) transferred into a bacterium with a delivery vehicle.

The term «payload» may also refer to a plasmid, a vector or a cargo.

The payload can be a phagemid or phasmid obtained from natural, evolved or engineered bacteriophage genome. The payload can also be composed only in part of phagemid or phasmid obtained from natural, evolved or engineered bacteriophage genome.

In some embodiment, the payload is the delivery vehicle as bacteria are naturally competent to take up a payload from the environment on their own.

«nucleic acid»

As used herein, the term “nucleic acid” refers to a sequence of at least two nucleotides covalently linked together which can be single-stranded or double-stranded or contains portion of both single-stranded and double-stranded sequence. Nucleic acids of the present invention can be naturally occurring, recombinant or synthetic. The nucleic acid can be in the form of a circular sequence or a linear sequence or a combination of both forms. The nucleic acid can be DNA, both genomic or cDNA, or RNA or a combination of both. The nucleic acid may contain any combination of deoxyribonucleotides and ribonucleotides, and any combination of bases, including uracil, adenine, thymine, cytosine, guanine, inosine, xanthine, hypoxanthine, isocytosine, 5-hydroxymethylcytosine and isoguanine. Other examples of modified bases that can be used in the present invention are detailed in Chemical Reviews 2016, 116 (20) 12655-12687. The term “nucleic acid” also encompasses any nucleic acid analogs which may contain other backbones comprising, without limitation, phosphoramide, phosphorothioate, phosphorodithioate, O-methylphosphoroamidite linkage and/or deoxyribonucleotides and ribonucleotides nucleic acids. Any combination of the above features of a nucleic acid is also encompassed by the present invention.

“Phagemid” and “packaged phagemid”

As used herein, the term “phagemid” or “phasmid” are equivalent and refer to a recombinant DNA vector comprising at least one sequence of a bacteriophage genome and which is preferably not able of producing progeny, more particularly a vector that derives from both a plasmid and a bacteriophage genome. A phagemid of the disclosure comprises a phage packaging site and optionally an origin of replication (ori), in particular a bacterial and/or phage origin of replication. In one embodiment, the phagemid does not comprise a origin of replication and thus cannot replicate by itself once injected into a bacterium. Alternatively, the phagemid comprises a plasmid origin of replication, in particular a bacterial and/or phage origin of replication.

As used herein, the term “packaged phagemid” refers to a phagemid which is encapsidated in a bacteriophage scaffold, bacterial virus particle or capsid. Particularly, it refers to a bacteriophage scaffold, bacterial virus particle or capsid devoid of a wild-type bacteriophage genome. The packaged phagemid may be produced with a helper phage strategy, well known from the man skilled in the art. The helper phage comprises all the genes coding for the structural and functional proteins that are indispensable for the phagemid according to the invention to be encapsidated. The packaged phagemid may be produced with a satellite virus strategy, also known from the man skilled in the art. Satellite virus are subviral agent and are composed of nucleic acid that depends on the co-infection of a host cell with a helper virus for all the morphogenetic functions, whereas for all its episomal functions (integration and immunity, multicopy plasmid replication) the satellite is completely autonomous from the helper. In one embodiment, the satellite genes can encode proteins that promote capsid size reduction of the helper phage, as described for the P4 Sid protein that controls the P2 capsid size to fit its smaller genome.

«peptide»

As used herein, the term “peptide” refers both to a short chain of at least 2 amino acids linked between each other and to a part of, a subset of, or a fragment of a protein which part, subset or fragment being not expressed independently from the rest of the protein. In some instances, a peptide is a protein. In some other instances, a peptide is not a protein and peptide only refers to a part, a subset or a fragment of a protein. Preferably, the peptide is from 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 amino acids to 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 25, 30, 40, 50, 100, 200 amino acids in size.

“homology” and “identity”

By “homology” is meant herein the amino acid sequence of two or more amino acid molecules is partially or completely identical. In certain embodiments the homologous amino acid sequence has 30%, 40%, 50%, 60%, 70%, 80%, 90%, or 95% sequence similarity or identity to the amino acid sequence of reference.

As used herein, the percent homology between two sequences is equivalent to the percent identity between the two sequences. The percent identity is calculated in relation to polymers (e.g., polynucleotide or polypeptide) whose sequences have been aligned. The percent identity between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % homology=# of identical positions/total # of positions x 100), taking into account the number of gaps, and the length of each gap, which need to be introduced for optimal alignment of the two sequences. The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm, as described in the non-limiting examples below.

The percent identity between two amino acid sequences can be determined using the algorithm of E. Meyers and W. Miller (Comput. Appl. Biosci., 4: 11-17 (1988)) which has been incorporated into the ALIGN program (version 2.0), using a PAM120 weight residue table, a gap length penalty of 12 and a gap penalty of 4. In addition, the percent identity between two amino acid sequences can be determined using the Needleman and Wunsch (J. Mol. Biol. 48:444-453 (1970)) algorithm which has been incorporated into the GAP program in the GCG software package (available at www.gcg.com), using a BLOSUM62 matrix, a BLOSUM30 matrix or a PAM250 matrix, and a gap weight of 16, 14, 12, 10, 8, 6, or 4 and a length weight of 1, 2, 3, 4, 5, or 6. In a specific embodiment the BLOSUM30 matrix is used with gap open penalty of 12 and gap extension penalty of 4.

Brief description of the sequences SEQ ID NO: Description Type 1 Payload encoding Adenine base editor (ABE8e) and DNA guideRNA targeting mCherry 2 Payload encoding Adenine base editor (ABE8e) and DNA guideRNA targeting ß-lactamase 3 Payload encoding Cytosine base editor DNA (evoAPOBEC1-nCas9-UGI) and guideRNA targeting mCherry 4 Payload encoding Cytosine base editor DNA (evoAPOBEC1-nCas9-UGI) and guideRNA targeting ß-lactamase 5 mCherry gene DNA 6 β-lactamase gene DNA 7 Primase ori deltaGAAABCC DNA 8 Primase ori devoid of restriction sites DNA 9 insulin B9-25 epitope Protein 10 T cell (β2GPI) epitope Protein 11 B cell epitope Protein 12 primase ori from the PICI of the Escherichia coli DNA strain CFT073 13 Restriction site DNA 14 PICI primase-helicase Protein 15 PICI primase-helicase DNA 16 Ro60 B cell epitope Protein 17 Ro60 T cell epitope (aa 316-335) Protein 18 Ro60 T cell epitope (aa 369-383) Protein 19-2313 Candidate mimic peptides Protein 2314 RFP gene DNA 2315 Payload encoding prime editor (PE) and pegRNA targeting DNARFP 2316 ClbP Protein 2317 ClbP gene DNA 2318 FimH Protein 2319 FimH gene DNA 2320 Blc Protein 2321 Blc gene DNA 2322 beta-galactosidase Protein 2323 beta-galactosidase gene DNA 2324 MYH6₆₁₄₋₆₂₉ Protein 2325 Payload encoding prime editor (PE) and pegRNA DNA targeting RFP and containing an inducible promoter

EXAMPLES Example 1—Method to Prevent Colorectal Cancer

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacteria results in single-amino acid mutations of the ClbP gene in pks+ E. coli and the inactivation of the genotoxic activity of the Colibactin toxin, but maintains the antagonistic activity of the toxin. The single-amino acid mutations of the ClbP gene in pks+ E. coli are a genetic modification selected from the group consisting of S95A, S95R and K98T¹. The bacteriophage vector is produced in E. coli to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the pks+ E. coli of the patient. The administration results in a population of E. coli in the patient in which the genotoxic activity of the Colibactin toxin has been inactivated, but the antagonistic activity of the toxin is maintained. Additional administrations over time further result in a diminution of the percentage of E. coli in the patient having a Colibactin toxin with genotoxic activity, while increasing the percentage of E. coli in the patient having a Colibactin toxin without genotoxic activity. In this way, the exposure of the patient to the negative effects of the genotoxic activity of the Colibactin toxin can be minimized.

Example 2—Method to Stop the Progression of Myocarditis

A method to stop the progression of myocarditis towards lethal cardiomyopathy by in situ genetic modification of the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase that shows high homology with human MYH6 cardiac peptide is developed².

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacteria results in single-amino acid mutations in the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase that decreases its homology with human MYH6 cardiac peptide, but maintains the activity of the enzyme. Multiple single-amino acid mutations are analyzed, starting with conservative mutations. The bacteriophage vector is produced in E. coli. to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the Bacteroides of the patient. The administration results in a population of Bacteroides in the patient in which the peptidic sequence of Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase has decreased homology with human MYH6 cardiac peptide. Additional administrations over time further result in a diminution of the percentage of Bacteroides in the patient having a peptidic sequence of Bacteroides beta-galactosidase with high homology with human MYH6 cardiac peptide, while increasing the percentage of Bacteroides in the patient having a peptidic sequence of Bacteroides beta-galactosidase with low homology with human MYH6 cardiac peptide. In this way, the exposure of the patient to the negative auto-immune effects caused by the immune cross-reactivity of the Bacteroides protein and the human MYH6 cardiac peptide can be minimized.

Example 3—Screening of Vectors

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in single-amino acid mutations of the ClbP gene in pks+ E. coli and the inactivation of the genotoxic activity of the Colibactin toxin. The single-amino acid mutations of the ClbP gene in pks+ E. coli will be a genetic modification selected from the group consisting of S95A, S95R and K98T¹.

The phagemid will be contacted with pks+ E. coli in vitro. The growth of modified and non-modified E. coli will be tested in liquid and solid culture with routine culture techniques to determine the effect of the modifications on growth in vitro.

The phagemid vectors will be then produced in E. coli. to high titers and a pharmaceutical composition will be prepared.

The pharmaceutical composition will be administered to a subject mouse to generate in-situ genetic modification of the pks+ E. coli of the mouse.

Fecal samples will be collected at daily timepoints and tested by PCR and sequencing to quantitate the levels of modified and un-modified E. coli. to determine the percentages of each over time. The comparison of levels of modified and un-modified E. coli over time allows for screening for the genetic modifications in the bacteria, for determining the efficiency of vectors at inducing these genetic mutations, and for determining the effects of these mutations on bacterial growth.

Example 4—Editing of Commensals Bacteria Expressing Ro60 Orthologue for Systemic Lupus Erythematosus (SLE) or Subacute Cutaneous Lupus Erythematosus (SCLE) Prevention or Treatment

A method to stop the apparition or progression of systemic lupus erythematosus (SLE) or subacute cutaneous lupus erythematosus (SOLE), by in situ genetic modification of the bacterial Ro60 orthologs, more specifically the epitopes of these orthologs.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in amino acid mutations in the peptidic sequence of the bacterial Ro60 orthologs that decreases its homology with human Ro60 peptide, but maintains the activity of the enzyme. Multiple single-amino acid mutations are analyzed, starting with conservative mutations. The bacteriophage vector is produced to high titers and a pharmaceutical composition is prepared. The pharmaceutical composition is administered to human patients to generate in-situ genetic modification of the patient. The administration results in one or several amino acid mutations in epitope regions of R060 orthologue for one or several commensal bacteria such as Propionibacterium propionicum.

The mutation is one or several non-synonymous mutations in:

-   -   the Ro60 B cell epitope (aa 169-190) (TKYKQRNGWSHKDLLRLSHLKP,         SEQ ID NO: 16), more specifically the amino acid change will be         in the bolded amino acids (TKYKQRNGWSHKDLLRLSHLKP, SEQ ID NO:         16).     -   the Ro60 T cell epitope (aa 316-335) (KARIHPFHILIALETYKTGH, SEQ         ID NO: 17) more specifically the amino acid change will be in         the bolded amino acids (KARIHPFHILIALETYKTGH, SEQ ID NO: 17).     -   the Ro60 T cell epitope (aa 369-383) (KRFLAAVDVSASMNQ, SEQ ID         NO: 18) more specifically the amino acid change will be in the         bolded amino acids (KRFLAAVDVSASMNQ, SEQ ID NO: 18).

A non-limiting list of human commensal bacteria whose genome contains a Ro60 ortholog is: Actinomyces massiliensis F0489 (HMPREF1318_2237), Actinomyces sp. Oral taxon 414 (AM609_00765), Corynebacterium amycolatum SK46 (CORAM0001_1910), Mycobacterium smegmatis (strain ATCC 700084/mc(2)155) (MSMEG_1193), Parascardovia denticolenslPLA 20019 (A200_07914), Propionibacterium prop F0230a (HMPREF9154_0590), Segniliparus rugosus ATCC BAA-974 (HMPREF9336_02315), Streptomyces sp. HGB0020 (HMPREF1211_06263), Bacteroides theta 7330 (Btheta7330_01248), Chryseobacterium gleum ATCC 35910 (HMPREF0204_10833), Prevotella sp. CAG:1092 (BN465_02442), Clostridium sp. BL8 (M918_10850), Paenibacillus sp. HGF7 (HMPREF9413_2200), Paenibacillus sp. HGH0039 (HMPREF1207_01859), Eikenella corrodens ATCC 23834 (EIKCOROL_00065), Kingella oralis ATCC 51147 (GCWU000324_03050), Neisseria elongata subsp. glycolytica ATCC 29315 (NEIELOOT_02899), Neisseria flavescens strain CD-NF1 (TV01_0020), Neisseria macacae ATCC 33926 (HMPREF9418_1500), Neisseria mucosa strain C6A (E517_04055), Neisseria shayeganii 871 (HMPREF9371_0707), Neisseria sicca ATCC 29256 (NEISICOT_02760), Neisseria sp. GT4A_CT1 (HMPREF1028_01178), Neisseria sp. oral taxon 020 str. F0370 (HMPREF9120_02756), Neisseria subflava NJ9703 (NEISUBOT_04391), Cardiobacterium valvarum F0432 (HMPREF9080_02018), Synergistes sp. 3_1_syn1 (HMPREF1006_01942).

More preferably the human commensal bacteria targeted by bacteriophage vector are: Propionibacterium propionicum, Corynebacterium amycolatum, Actinomyces massiliensis, Bacteroides thetaiotaomicron.

Example 5—Editing of Pathogenic Escherichia coli In Situ

E. coli is a commensal enterobacteria but specific strains have been associated with numerous pathology inside and outside the gut among which inflammatory bowel disease (IBD), urinary tract infection (UTI), Hemolytic uremic syndrome (HUS), Gastroenteritis or colorectal cancer. The pathogenicity of these specific strains originates from virulence genes some of which are acquired by horizontal gene transfer such as shiga toxin genes (stx) carried by temperate phages or by mutations in specific genes.

A method to reduce or abolish the pathogenic properties of the gut bacteria Escherichia coli by in situ genetic modification of peptidic sequence of virulence gene notably genes involved in the inflammatory properties of E. coli is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications. Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contact the bacterial population resulting in the mutation of one or several non-synonymous mutations in:

-   -   the FimH gene that results in reverting the following mutations:         N70S and S78N associated with AEIC strains¹.     -   the ChiA gene that results in reverting the following mutations:         K362Q, K370E, A378V, E388V, V548E²⁴     -   the OmpA gene that results in reverting the following mutation:         A200V²⁵     -   the OmpC gene that results in reverting the following mutation:         V220I, D232A²⁵     -   the OmpF gene that results in reverting the following mutation:         E51V, M60K²⁵     -   the blc gene in E. coli that results in reverting the following         mutation G84E (G251A at the nucleotide level) potentially         associated to gut inflammation⁴

Example 6—Editing of Staphylococcus epidermidis In Situ

Staphylococcus epidermidis is with Cutibacterium acnes one of the two most prevalent and abundant commensal bacteria on the human skin. As such it has been shown to prevent colonization by pathogenic bacteria like its close relative Staphylococcus aureus, prevent skin cancer or also modulate the human immune system. However, it is also a growing concern due to its opportunistic pathogenic characteristic and its growing resistance to antibiotics. These pathogenic traits of S. epidermis might be encoded on specific virulence genes or cluster and some of these might spread across strains by horizontal gene transfer.

A method to reduce or abolish the pathogenic properties of S. epidermidis by in situ genetic modifications of peptidic sequences of virulence genes is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a primer editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The packaged phagemid contacting the bacterial population results in one or several genetic mutations that lead to reduction or elimination of the pathogenicity. This can be done by for example: non-synonymous mutations, mutations leading to gene disruption such as introduction of stop codons or mutations in regulatory sequences such as promoter, transcription binding sites.

The genetic mutations is targeted towards one or several genes associated with S. epidermidis infection as described in Méric et al²⁷ and listed here: id1001_1081, SE_p608, SE0037, SE0038, SE_p609, id1001_1086, SE0058, SE_p205, SE_p603, SEA0027, SE0036, SE0033, SE0053, SE0055, SE_p522, SE_p610, SE_p611, id1001_1083, id1067_0124, id268_0008, SE0090, SE2153, id1001_0181, id1067_0123, id1074_1993, SE0023, SE0030, SE0103, SE0120, SE0129, SE_p607, SEA0003, id1001_2175, id1001_2181, SE0031, SE0069, SE0076, SE0107, SE0115, SE_p602, SE_p606, SEA0022, SEA0030, id2_1533, id1001_0179, id1001_0180, id1001_0186, id1001_0194, id1001_0203, id1001_2173, id1001_2184, id1001_2209, id1067_0125, id1067_0126, id1074_0268, id1075_0004, id1092_0129, SE0004, SE0020, SE0114, SE0127, SE0282, SE1013, SE1106, SE1292, SE2395, SE_p605, SEA0004, SEA0008, id1001_0187, id1001_2183, id1001_2208, id1021_0918, id1074_0267, SE0005, SE0021, SE0050, SE0063, SE0118, SE1588, SE1632, SE1920, SE_p507, SEA0002, SEA0020, SEA0021, id1001_0910, id1001_2159, id1001_2206, id1021_0613, id1032_2361, id1032_2362, id1067_0112, id1067_0226, id1067_0227, id1067_1124, id429_2314, SE0045, SE0051, SE0054, SE0101, SE0109, SE0112, SE0116, SE0119, SE0145, SE0175, SE0803, SE0852, SE1092, SE1102, SE1103, SE1107, SE1118, SE1128, SE1429, SE1455, SE1587, SE1607, SE1983, SE2011, SE2079, SE2208, SE2251, SE2260, SE2409, SE_p103, SE_p508, SE_p521, SEA0005, id1001_0007, id1001_0010, id1001_0183, id1001_0191, id1001_0199, id1001_0912, id1001_1283, id1001_2163, id1001_2164, id1001_2169, id1001_2174, id1001_2185, id1031_0178, id1067_0113, id1074_2138, id429_2315, id429_2316, id429_2317, id429_2319, SE0001, SE0009, SE0016, SE0032, SE0071, SE0102, SE0104, SE0106, SE0108, SE0111, SE0122, SE0146, SE0148, SE0182, SE0197, SE0230, SE0231, SE0240, SE0263, SE0273, SE0306, SE0629, SE0800, SE0804, SE0805, SE0815, SE0817, SE0825, SE0828, SE1037, SE1094, SE1096, SE1105, SE1458, SE1605, SE1606, SE1613, SE1728, SE1917, SE1919, SE1921, SE2160, SE2192, SE2220, SE2257, SE_p410, id1001_0011, id1001_0182, id1001_0190, id1001_1084, id1001_1085, id1001_1264, id1001_1972, id1001_1984, id1001_1986, id1001_2203, id1005_0195, id1005_1733, id1005_1734, id1021_0933, id1021_1637, id1021_1670, id1021_1674, id1031_0580, id1031_0911, id1031_0919, id1031_0920, id1031_0922, id1031_1192, id1067-0106, id1067-0107, id1067-0111, id1067_1095, id1067_1493, id1091_1647, id505_1243, SE0002, SE0003, SE0008, SE0010, SE0019, SE0034, SE0064, SE0105, SE0110, SE0128, SE0137, SE0140, SE0157, SE0162, SE0181, SE0183, SE0186, SE0191, SE0241, SE0248, SE0253, SE0254, SE0266, SE0268, SE0307, SE0331, SE0470, SE0692, SE0693, SE0694, SE0802, SE0806, SE0841, SE0917, SE1059, SE1083, SE1090, SE1104, SE1211, SE1459, SE1598, SE1628, SE1637, SE1649, SE1770, SE1772, SE1777, SE1872, SE1897, SE1900, SE1918, SE1925, SE1926, SE1927, SE1931, SE1985, SE2021, SE2042, SE2044, SE2045, SE2091, SE2124, SE2152, SE2193, SE2201, SE2221, SE2222, SE2244, SE2246, SE2250, SE2401, SE2403, SE2408, SE_p203, SE_p206, SE_p405, SE_p406, SE_p506, SEA0001, SEA0029, id2_1530, id1001_0188, id1001_0911, id1001_1285, id1001_1982, id1005_1719, id1021_0758, id1021_0930, id1021_1658, id1021_1663, id1021_2114, id1031_1153, id1031_1190, id1031_1202, id1031_1222, id1031_1428, id1067-1094, id1067-1098, id1067-1099, id1067-1106, id1067-1135, id1091_2272, id1120_2061, id262_0707, id262_0708, id304_0202, id53_0678, SE0013, SE0015, SE0022, SE0121, SE0126, SE0135, SE0142, SE0149, SE0152, SE0185, SE0194, SE0196, SE0212, SE0226, SE0232, SE0237, SE0242, SE0243, SE0259, SE0262, SE0269, SE0272, SE0274, SE0275, SE0276, SE0278, SE0279, SE0281, SE0299, SE0305, SE0355, SE0435, SE0456, SE0604, SE0673, SE0689, SE0701, SE0704, SE0705, SE0707, SE0716, SE0779, SE0782, SE0808, SE0814, SE0818, SE0836, SE0839, SE0990, SE1082, SE1097, SE1108, SE1109, SE1122, SE1136, SE1138, SE1196, SE1207, SE1288, SE1456, SE1464, SE1546, SE1574, SE1580, SE1585, SE1589, SE1603, SE1604, SE1643, SE1735, SE1773, SE1827, SE1836, SE1899, SE1914, SE1915, SE1938, SE1946, SE2005, SE2022, SE2036, SE2041, SE2043, SE2052, SE2071, SE2074, SE2090, SE2116, SE2148, SE2149, SE2154, SE2167, SE2175, SE2194, SE2198, SE2199, SE2210, SE2215, SE2223, SE2225, SE2229, SE2259, SE2306, SE2314, SE2333, SE2337, SE2342, SE2379, SE2388, SE2394, SE_p411, SEA0006, id1001_0185, id1001_2167, id1001_2190, id1005_0702, id1005_0703, id1005_0704, id1005_1752, id1021_0787, id1021_1631, id1021_1651, id1021_1652, id1021_1667, id1021_1669, id1021_1671, id1021_1673, id1031_1154, id1031_1160, id1031_1169, id1031_1173, id1031_1179, id1031_1182, id1031_1431, id1031_2369, id1032_2377, id1036_1869, id1036_1871, id1067_1096, id1067_1097, id1067_1104, id1067_1117, id1067_1130, id1068_0108, id1068_0584, id1074_1751, id1074_2133, id1091_2269, id1092_1189, id267_0755, id324_1262, SE0014, SE0066, SE0117, SE0123, SE0134, SE0144, SE0163, SE0180, SE0195, SE0223, SE0229, SE0250, SE0251, SE0255, SE0261, SE0280, SE0301, SE0410, SE0444, SE0450, SE0455, SE0615, SE0637, SE0657, SE0663, SE0664, SE0669, SE0670, SE0683, SE0684, SE0690, SE0700, SE0706, SE0713, SE0785, SE0790, SE0797, SE0813, SE0816, SE0832, SE0909, SE1075, SE1080, SE1085, SE1089, SE1121, SE1132, SE1133, SE1175, SE1183, SE1184, SE1210, SE1212, SE1311, SE1348, SE1397, SE1408, SE1442, SE1460, SE1470, SE1516, SE1577, SE1581, SE1629, SE1635, SE1726, SE1727, SE1779, SE1785, SE1932, SE1949, SE1953, SE1954, SE1957, SE1959, SE1978, SE2012, SE2019, SE2023, SE2037, SE2046, SE2053, SE2054, SE2075, SE2085, SE2087, SE2088, SE2093, SE2094, SE2095, SE2114, SE2186, SE2191, SE2197, SE2213, SE2228, SE2230, SE2232, SE2242, SE2245, SE2247, SE2252, SE2253, SE2255, SE2256, SE2258, SE2298, SE2380, SE2384, SE2393, SE2396, SE2397, SE2406, SE2407, SE2411, SE2412, SE2415, SE_p409, SEA0033, id2_0245, id1001_0986, id1001_2165, id1021_0310, id1021_1615, id1021_1628, id1021_1635, id1021_1638, id1021_1654, id1021_1655, id1021_1659, id1021_1668, id1031_1165, id1031_1170, id1031_1171, id1031_1172, id1031_1174, id1031_1178, id1031_1181, id1031_1183, id1031_1224, id1031_1432, id1032_2373, id1067_1146, id1068_0610, id1074_0173, id1121_0371, id267_0744, id267_0753, id268_1096, id277_0533, id277_0629, id284_0382, id312_1160.

Preferably the genetic mutations is targeted towards one or several genes associated with S. epidermidis infection in the following list: SE0023, SE0101, SE0121, SE0128, SE0275, SE0281, SE0307, SE1105, SE1128, SE1459, SE2197, SE2245, SE2259, SE_p521, id1001_2159, id1068_0108, id1091_1647, SE0197, SE0704, SE0705, SE0706, SE0707, SE1632, SE2201, id1001_0010, SE0004, SE0030, SE0031, SE0033, SE0036, SE0050, SE0053, SE0055, SE0076, SE0090, SE0111, SE1897, id1067_0123, id1067_0124, id1067_0125, id1067_0126, id1067_0226, id1067_0227, SE0102, SE0103, SE0104, SE0105, SE0106, SE0107, SE0108, SE0110, SE0117, SE0157, SE0175, SE0673, SE0818, SE0828, SE1311, SE1637, id1067_1493, id324_1262.

Example 7—Base Editing of mCherry on the E. coli Genome after Transformation In Vitro

This example presents a method for the base editing of the nucleic acid sequence encoding fluorescent protein mCherry (SEQ ID NO: 5) on the E. coli MG1655 genome after transformation with a DNA payload encoding a base editor. Fluorescence was measured by flow cytometry of individual colonies after transformation and overnight selection on chloramphenicol plates.

As shown on FIG. 4A, the adenine base editor ABE8e (SEQ ID NO: 1, plasmid map shown on FIG. 7) deactivated the active site of mCherry (tripeptide: M71, Y72, G73) while enabling the translation of the full-length protein.

As shown on FIG. 4B, the cytosine base editor (evoAPOBEC1-nCas9-UGI; SEQ ID NO: 3, plasmid map shown on FIG. 8) inserted a stop codon (Q114) into the target gene mCherry resulting in the loss of fluorescence.

As a control, base editors were transformed in the absence of a guideRNA (2 colonies analysed) leading to fluorescent mCherry expression.

All of the 48 analysed colonies targeting mCherry via the same guideRNA were successfully edited, leading to a loss of fluorescence. The mCherry gene of five colonies was sequenced, which confirmed successful base editing.

Example 8—Base Editing of β-Lactamase on the E. coli Genome after Packaged Phagemid Transduction In Vitro

This example presents a method for the base editing of the nucleic acid sequence encoding β-lactamase (SEQ ID NO: 6) on the E. coli MG1655 genome after packaged phagemid transduction in vitro. As shown on FIG. 5A, production of packaged lambda phagemids (within a bacterial delivery vehicle comprising an A8 gpJ protein and a P2 STF protein enabling transduction into MG1655 strain) encoding a base editor (ABE or CBE) and a transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome, and further carrying a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication, resulted in titers of ˜10⁸ transduction units (tu) per μl.

Cells were plated on carbenicillin plates 2 hours post transduction in order to analyse base editing efficiency.

As shown on FIG. 5B, the efficiency of adenine base editing (using ABE8e; SEQ ID NO: 2) targeting the active site of the β-lactamase gene (K71E) on the genome was multiplicity of infection (MOI)-dependent. The efficiency of cytosine base editing (using evoAPOBEC1-nCas9-UGI; SEQ ID NO: 4) inserting a stop codon into the β-lactamase gene on the bacterial genome was also MOI-dependent (FIG. 5C). ABE or CBE resulted in ˜4 log or ˜3 log reduction of cell growth at high MOIs, respectively.

Example 9—Adenine Base Editing of β-Lactamase after Transduction into E. coli in oligoMM Mice In Vivo

This example presents a method for the adenine base editing (using ABE8e, SEQ ID NO: 2) of a target gene (β-lactamase; SEQ ID NO: 6) after phagemid transduction into E. coli in an oligo-mouse-microbiota model in vivo.

The packaged phagemid titer (within a bacterial delivery vehicle comprising an A8 gpJ protein and a P2 STF protein enabling transduction into MG1655 strain) for the in vivo experiment was 1.5×10⁹ transduction units per μl (tu/μl). Said phagemid carries the expressed adenine base editor ABE8e under the SrpR promoter and a constitutively transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome. Furthermore, said phagemid carries a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication.

An E coli strain carrying the β-lactamase gene was administered to 10 individual mice aged 7 weeks at 10⁷ CFU per mouse. Two packaged phagemid doses (100 μl packaged phagemid+100 μl sucrose bicarbonate per mouse) were orally administered to the mice at 0 h and 30 h. Stool samples were analysed 0, 6, and 48 hours post initial phagemid transduction (48, 96, 88 colonies, respectively).

Cells were plated on streptomycin, chloramphenicol, and carbenicillin plates in order to analyse delivery and editing efficiency. Editing of the active site of β-lactamase (K71E) resulted in a loss of cell growth on carbenicillin plates.

As shown on FIG. 6, after 48 hours, ˜49% of the targeted bacteria population carried the DNA payload and ˜30% of the whole population were base edited in vivo. The percentage of payload delivery could be further increased by higher phagemid titers and/or cumulative doses.

Example 10—Prime Editing of Red Fluorescent Protein (RFP) on the E. coli Genome In Vitro

This example presents a method for the prime editing of the nucleic acid sequence encoding the Red Fluorescent Protein RFP (SEQ ID NO: 2314) on the E. coli genome after transformation with a DNA payload (FIG. 9). The payload encodes a prime editor (PE; payload of sequence SEQ ID NO: 2315), a transcribed prime editing guide RNA (pegRNA), a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication. The pegRNA consists of an extended single guide RNA containing a primer binding site and a reverse transcriptase sequence in order to replace RFP's amino acid E16 (GAA) with a stop codon (TAA) on the bacterial genome.

The prime editor (PE; payload of sequence SEQ ID NO: 2315) was engineered to insert a stop codon at position E16 of the target gene RFP resulting in a loss of red fluorescence.

As a control, the prime editor was transformed in the absence of a pegRNA leading to fluorescent RFP production.

The genomic RFP gene was amplified from 18 individual colonies after transformation and overnight selection on chloramphenicol plates. The resulting PCR fragments were sequenced and the editing efficiency calculated.

As shown in FIG. 9, the stop codon was present in four of these individual colonies (˜22% of the bacterial population) confirming successful prime editing.

Example 11: Description of the System Used for Non-Replicative Payloads

The inventors developed a system in which the payload contains the 282-bp primase origin and the primase protein is supplied in trans (SEQ ID NO: 8 and SEQ ID NO: 14). To simplify the engineering process, the PICI primase gene was extracted from the genome of E. coli CFT073, cloned into a plasmid under the control of an inducible system and an RBS (ribosome-binding site) library generated. This series of plasmids were cloned in the lambda production strain s1965. Next, the inventors constructed a small payload harboring the primase-ori instead of the p15a-based origin of replication to yield a 2.3 kb payload. Since this plasmid is, in principle, non-replicative, competent cells of s1965 harboring the RBS library of inducible primase constructs were made, the plasmid transformed in them and plated in LB agar+kanamycin and chloramphenicol in the presence of the inducer DAPG (to induce the expression of the primase in trans). Next day, the inventors observed that the plates contained hundreds of colonies, suggesting that the primase-origin system in trans works (FIG. 11).

Several clones were sequenced to verify that the plasmid contained no p15a-based origin and that they also contained an intact primase gene with an RBS coming from the library.

After that, 7 of these clones were grown overnight and lambda productions were carried out in the presence of kanamycin, chloramphenicol and DAPG. As a control, the inventors included the original 2.8 kb plasmid containing a derivative of the p15a origin of replication to compare titers.

To verify the sequence of the RBS variants obtained, the plasmid encoding the inducible primase in the 7 clones tested was miniprepped and sequenced. They were also transformed into MG1655 cells (s003): these strains were used to verify the titers obtained, since the payloads should not be replicative in the absence of the primase protein supplied in trans.

As can be seen on FIG. 12, the titers of 5 out of 7 primase-containing samples, as measured in MG1655 containing the primase plasmid in trans, were the same as those of a packaged phagemid carrying the original modified p15a origin.

Finally, the inventors tested if the primase-ori containing payloads could replicate in MG1655 strains without the primase plasmid in trans. To do this, serial 5X dilutions of the primase-ori containing plasmids coming from the production strains with different primase RBS, plus a p15a-origin control, were transduced into a dense culture (OD600 ˜0.8) of MG1655 and plated on LB agar plates containing chloramphenicol. As can be seen on FIG. 13, while the p15a-origin control shows healthy colonies up to the last dilution, indicative of active plasmid replication, the samples containing the primase-containing payload show colonies only at high MOIs: since the strain will lose the payload by division, those drops that contained a high number of transduced bacteria will appear as dense spots since division will be halted at high cell densities; as the MOIs are reduced, the spots become more transparent and single colonies are hard to distinguish, indicative of cells that are dying due to plasmid loss and exposure to antibiotics. This is also indicative of a burst of expression of the chloramphenicol acetyltransferase gene upon transduction, which, in the absence of active replication, will get diluted over time; this may cause the receiver cells to survive for a certain amount of time until the intracellular concentration of chloramphenicol acetyltransferase drops below a critical level to support growth in antibiotic-supplemented media.

Example 12—Adenine Base Editing of β-Lactamase on the E. coli Genome after Packaged Phagemid Transduction In Vitro Using a Non-Replicative Payload

This example presents a method for the base editing of the nucleic acid sequence encoding β-lactamase (SEQ ID NO: 6) on the E. coli MG1655 genome after packaged phagemid transduction in vitro using a non-replicative payload based on a primase-helicase as disclosed in Example 11 (FIG. 10). The non-replicative payload consists of an adenine base editor (ABE8e), a transcribed guideRNA targeting the active site of the β-lactamase gene (K71E) on the genome, a lambda packaging sequence, a chloramphenicol resistance marker, and the conditional origin of replication (dependent on the presence of a primase-helicase) of sequence SEQ ID NO: 8. Production of lambda phagemids, packaged inside a bacterial delivery vehicle comprising an A8 gpJ protein and a p2 STF protein for delivery into E. coli MG1655, resulted in titers of 7.4×10⁷ transduction units per μl (tu/μl).

Transduced cells were plated on LB and LB (carbenicillin) 2 hours post transduction at different multiplicity of infections (MOI). The next day, base editing efficiency was analyzed via colony counting.

As can be seen on FIG. 10, the efficiency of adenine base editing targeting the active site of the β-lactamase gene (K71E) on the genome was multiplicity of infection (MOI)-dependent. A base editing efficiency of >4 logs was obtained at high MOIs using the non-replicative payload, confirming the efficiency of base editing even using a conditional origin of replication which prevents replication of the payload inside the targeted E. coli MG1655 bacteria.

Example 13—Base Editing of β-Lactamase on the E. coli Genome after Phagemid Transduction in oligoMM Mice In Vivo Using a Non-Replicative Payload Based on a Primase-Helicase

This example presents a method for the adenine base editing (ABE8e-primase, SEQ ID NO: 2) of a target gene (e.g. β-lactamase; SEQ ID NO: 6) after packaged phagemid transduction in vivo into E. coli in an mouse colonization model. The packaged phagemids titer for the in vivo experiment was 1.5×10¹⁰ transduction units per μl (tu/μl) after purification.

An E. coli strain carrying the β-lactamase gene in the genome was orally administered to 10 female mice aged 7 weeks at 10⁷ CFU per mouse. A packaged phagemids dose of 1.5×10¹² to (ie 100 μl, buffered with 100 μl of sucrose bicarbonate) was orally administered to the mice (TO). Stool samples were collected immediately before this administration, as well as 24 hours after (T24h). Stool homogenates were plated on selective medium, and individual clones were further repatched on agar plates with or without carbenicillin in order to analyse editing efficiency (20 colonies per mouse and per time point). Editing of the active site of β-lactamase (K71E) resulted in a loss of bacterial growth on carbenicillin plates. At T24h, ˜75% of the whole population was base-edited on average (see FIG. 14).

Example 14—Prime Editing of β-Lactamase on the E. coli Genome after Phagemid Transduction In Vitro

This example presents a method for the prime editing of the nucleic acid sequence encoding the Red Fluorescent Protein RFP (SEQ ID NO: 2314) on the E. coli genome after transduction with a DNA payload. The payload (SEQ ID NO: 2325) encodes a prime editor (PE), a transcribed prime editing guide RNA (pegRNA) under the inducible promoter pBetI, a lambda packaging sequence, a chloramphenicol resistance marker, and a p15A origin of replication. The pegRNA consists of an extended single guide RNA containing a primer binding site and a reverse transcriptase sequence in order to replace RFP's amino acid E16 (GAA) with a stop codon (TAA) on the bacterial genome.

The prime editor was engineered to insert a stop codon at position E16 of the target gene RFP resulting in a loss of red fluorescence.

Production of packaged phagemids comprising an A8 gpJ protein and a p2 STF protein for delivery into E. coli MG1655, resulted in titers of 2.6×10⁷ transduction units per μl (tu/μl).

The fluorescence of colonies was analyzed by flow cytometry after overnight selection on chloramphenicol and 10 mM choline chloride and repatching on chloramphenicol plates. The genomic RFP was amplified from non-fluorescent colonies and the resulting PCR fragments were sequenced and the editing efficiency calculated. The stop codon was present in one of these individual colonies confirming successful prime editing after phagemid transduction.

Example 15—Editing of E. faecalis, E. Faecium and/or L. brevis Expressing Tyrosine Decarboxylase for Preventing L-DOPA Inactivation when Treating Subjects Suffering from Parkinson's Disease

In recent years, it was shown that the microbial decarboxylases that are part of gut microbial organisms appear to be able to metabolise L-DOPA (levodopa). Novel bacterial L-DOPA metabolism by tyrosine decarboxylases (tyrDCs) has been identified, dominantly driven by Enterococcus faecalis (Maini Rekdal et al. Science 2019; 364) but also E. faecium and L. brevis. Mutating these tyrDCs in E. faecalis, E. faecium and/or L. brevis can block this bacterial L-DOPA-to-dopamine metabolism, thereby improving drug efficacy.

A method to prevent the expression of a functional tyrosine decarboxylase of Enterococcus faecalis, E. faecium and/or L. brevis by in situ genetic modification of the gene sequence encoding said tyrosine decarboxylase is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a prime editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications, and a transcribed guideRNA targeting the catalytic site of tyrosine decarboxylase. The guideRNA is designed to introduce a stop codon in the catalytic site of said enzyme, rendering it inactive.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contacts the bacterial population resulting in at least one mutation resulting a stop codon in the catalytic site of tyrosine decarboxylase.

Treating patients suffering from Parkison's disease with L-DOPA in combination with such packaged phagemids leads to a better efficacy of L-DOPA.

Example 16—Editing of Clostridium sporogenes Expressing DHPAA Synthase for Preventing L-DOPA Deamination when Treating Subjects Suffering from Parkinson's Disease

Levodopa is absorbed in the small intestine, however, 9-10% of unabsorbed “residual” L-dopamine is metabolised further down in the gut (this percentage increases with age and administered drug dose). The metabolite that results from this reaction—DHPPA—affects gut motility and constipation. This deamination can be mediated by Clostridium sporogenes which expresses DHPAA synthase. Constipation is a known side effect of Levodopa and inhibitors of this deamination could be beneficial.

A method to prevent the expression of a functional DHPAA synthase of C. sporogenes by in situ genetic modification of the gene sequence encoding said DHPAA synthase is described below.

A phagemid is generated containing a phage packaging site, a base editor enzyme containing a dCas9 or nCas9 fused to a deaminase domain for inducing genetic modifications or a prime editor enzyme containing a dCas9 or nCas9 fused to a reverse transcriptase domain for inducing genetic modifications, and a transcribed guideRNA targeting the catalytic site of DHPAA synthase The guideRNA is designed to introduce a stop codon in the catalytic site of said enzyme, rendering it inactive.

Packaged phagemids are produced following a standard thermal induction protocol²⁶.

The phagemid contacts the bacterial population resulting in at least one mutation resulting in a stop codon in the catalytic site DHPAA synthase.

Treating patients suffering from Parkison's disease with L-DOPA in combination with such packaged phagemids leads to reduced side effects, in particular reduced constipation.

TABLE 1 Gut bacterial species carrying candidate mimic peptide, amino acids sequence of related mimic peptide and Uniprot ID of bacterial and human protein containing each mimic peptide Uniprot ID of Uniprot ID of bacterial protein human protein SEQ Candidate mimic Gut Bacterial species carrying containing mimic containing ID NO: peptide candidate mimic peptide peptide mimic peptide 19 AAAKHLTPV Pseudomonas putida Q84DC3 P51648 20 AACEAAVGL Desulfovibrio desulfuricans B8J1D0 P03901 21 AAGMNAAVR Lactobacillus salivarius Q1WTT3 Q01813 22 AAHGNSLRGI Parabacteroides distasonis, A6L9K8, B2RHB7, P15259 Porphyromonas gingivalis, Q7MXP1 Porphyromonas gingivalis 23 AALGSDTGGS Lactobacillus casei, Lactobacillus B3WD57, Q03AC0, Q9H0R6 casei, Lactobacillus johnsonii, Q74152, Q041KS, Lactobacillus gasseri, Lactobacillus Q5FLL1, A8YTZ6, acidophilus, Lactobacillus helveticus, Q04BV7, Q1GBF4, Lactobacillus delbrueckii, C4Z3J4, A0RNK4, Lactobacillus delbrueckii, Q9ZL13, Q9JYZ9, Eubacterium eligens, Campylobacter Q5F8U8, B4RM85, fetus, Helicobacter pylori, Neisseria A1KUH8, A9M003, meningitidis, Neisseria gonorrhoeae, Q03EG5 Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis, Pediococcus ntosaceus 24 AAPFGGVKQSG Rhizobium sp. P55653 Q3SY69 25 AAPGSKTTQ Aeromonas salmonicida, Aeromonas A4SMI9, A0KKI5, Q08J23 hydrophila, Citrobacter koseri, A8AFL6, A4WBJ4, Enterobacter sp., Escherichia coli, Q0TGZ7, Q8FGS9, Escherichia coli, Escherichia coli, Q1RAV2, A1ACO0, Escherichia coli, Escherichia coli, B7MBP2, B7USL2, Escherichia coli, Escherichia coli, P76273, B1XHA3, Escherichia coli, Escherichia coli, C4ZZJ2, B6IBR3, Escherichia coli, Escherichia coli, B7M2B1, B7MVW5, Escherichia coli, Escherichia coli, B7L7N7, A7ZMV8, Escherichia coli, Escherichia coli, B7NBI3, B1LD37, Escherichia coli, Escherichia coli, B7NS84, B5YQX9, Escherichia coli, Escherichia coli, Q8XCL9, B7LPL0, Escherichia fergusonii, Escherichia B1J0Q3, A8A133, coli, Escherichia coli, Klebsiella A6TB06, B5X035 pneumoniae, Klebsiella pneumoniae 26 AAPGTIRGD Parabacteroides distasonis A6LCB6 O00746 27 AAPGTIRGDF Streptococcus uberis, Streptococcus B9DSE2, Q5M011, O00746 thermophilus, Streptococcus Q5M4M4 thermophilus 28 AAVEMRDNP Enterobacter sp., Escherichia coli, A4W6W8, Q1RFU0, Q9UBT6 Escherichia coli, Escherichia coli, Q0TL85, A1A7U2, Escherichia coli, Escherichia coli, Q47155, B1J100, Escherichia coli, Escherichia coli, A7ZHZ2, P59477, Escherichia coli, Escherichia coli, A7ZWJ6, Q8X7Q1, Escherichia fergusonii P58963 29 AAVPSGASTG Clostridium botulinum, Clostridium C1FQW6, A7FQP0, P06733 botulinum, Clostridium botulinum, B1IDB9, A7G9Y3, Clostridium botulinum, Clostridium B1KTJ8, C3KZ49 botulinum, Clostridium botulinum 30 ACGTSYHAG Listeria innocua, Listeria Q92DS8, Q722H1, Q06210 monocytogenes, Listeria Q8Y915, Q88BX8, monocytogenes, Pseudomonas Q87TT8 putida, Pseudomonas syringae 31 ADFIGKQAL Listeria innocua Q92C06 Q9UI17 32 ADIGWITGH Helicobacter pylori, Helicobacter B5Z6E9, Q17WR1, Q9NUB1 acinonychis, Helicobacter pylori O25686 33 ADIITPNQFE Corynebacterium diphtheriae Q6NG19 O00764 34 ADIVTTTTHKTLRG Lactobacillus acidophilus Q5FMC0 P34897 35 ADVGLVGFP Corynebacterium urealyticum, B1VGL9, Q03YT6, A4D1E9 Leuconostoc mesenteroides, B1N057 Leuconostoc citreum 36 ADVGLVGFPN Desulfitobacterium hafniense, B8FUR9, Q24SP0, A4D1E9 Desulfitobacterium hafniense, Q892N8 Clostridium tetani 37 ADVGLVGFPNAG Bacteroides thetaiotaomicron, Q89ZI9, A6LD68, A4D1E9 KS Parabacteroides distasonis, A6L100, Q64XA5, Bacteroides vulgatus, Bacteroides Q5LGG9, Q7MW55, fragilis, Bacteroides fragilis, B2RIY7 Porphyromonas gingivalis, Porphyromonas gingivalis 38 ADYLWNVSSPNT Kocuria rhizophila, Streptomyces B2GHT4, Q9KXR7, Q02127 coelicolor, Streptomyces griseus, B1W464, Q827Q6 Streptomyces avermitilis 39 AEAYDVLSDP Porphyromonas gingivalis, Q9XCA6, B2RLJ0 P59910 Porphyromonas gingivalis 40 AEDYHQQYL Corynebacterium efficiens, Q8FLU6, Q8NLL5, Q9UJ68 Corynebacterium glutamicum, A4QHY3, Q9APY4 Corynebacterium glutamicum, Corynebacterium melassecola 41 AEIETDKAT Rhizobium meliloti, Rhizobium meliloti Q9R9N3, Q9R9N4 P10515 42 AESGWDFSSRW Ralstonia solanacearum Q8XT38 O43280 43 AESWDNVGLL Staphylococcus epidermidis, Q8CSD9, Q5HNY9, Q9GZT8 Staphylococcus epidermidis, Q6G907, Q8NWB9, Staphylococcus aureus, P67273, P67272, Staphylococcus aureus, Q5HFK1, Q6GGE0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 44 AETEAQRRQA Methylobacterium sp. B0UJI9 Q969Y2 45 AFDRILASRMG Haemophilus influenzae, P43863, A5UD89, Q01813 Haemophilus influenzae, Q4QLS8 Haemophilus influenzae 46 AFDRILASRMGV Haemophilus parasuis B8F8G9 Q01813 47 AFGFMTRVA Ralstonia pickettii B2UGY6 P61457 48 AFGFMTRVAL Ralstonia solanacearum Q8XU38 P61457 49 AFLTVSGQL Enterobacter sp., Haemophilus A4W8U9, Q7VLL7 Q96159 ducreyi 50 AFMLPVATPPNAI Haemophilus influenzae Q57486 Q86YT5 VF 51 AGAESGWDFSSR Pseudomonas aeruginosa Q9I165 O43280 WL 52 AGAMENWGLVTY Lactobacillus helveticus, Lactobacillus Q10730, P37896 P15144 RE delbrueckii 53 AGASLVQLY Pseudomonas stutzeri, Pseudomonas A4VM41, Q4KFI7, Q02127 fluorescens, Pseudomonas C3K017 fluorescens 54 AGASLVQLYT Akkermansia muciniphila B2UNA2 Q02127 55 AGDGTTTAT Clostridium botulinum, Clostridium Q8KJ24, Q891G4, P10809 tetani, Clostridium novyi, Desulfovibrio A0Q2T1, Q30YH6, alaskensis, Desulfovibrio vulgaris, A1VCQ0, Q72AL6 Desulfovibrio vulgaris 56 AGDGTTTATVL Streptococcus agalactiae, Q8CX00, Q3JYQ0, P10809 Streptococcus agalactiae, Q8CX22 Streptococcus agalactiae 57 AGDGTTTATVLA Aeromonas salmonicida, Aeromonas A4SR80, A0KGL1, P10809 hydrophila, Aggregatibacter P46398, Q65MZ8, actinomycetemcomitans, Bacillus Q5WJN4, A7Z207, licheniformis, Bacillus clausii, Bacillus A8FAG3, O50305, methylotrophicus, Bacillus pumilus, B9KCR7, A1W0K4, Bacillus halodurans, Campylobacter O69289, Q5HTP2, lari, Campylobacter jejuni, A8FMS6, A7H2F8, Campylobacter jejuni, Campylobacter A7I0W5, A7ZCV2, jejuni, Campylobacter jejuni, A8AMQ6, C5BDK5, Campylobacter jejuni, Campylobacter O66190, O66200, hominis, Campylobacter concisus, Q66198, A4W5N8, Citrobacter koseri, Edwardsiella Q19NJ4, Q1R3B6, ictaluri, Enterobacter asburiae, B1LQG4, B61615, Enterobacter agglomerans, B7NG81, B1ITQ5, Enterobacter aerogenes, P0A6F5, A8A7N9, Enterobacter sp., Escherichia coli, P0A6F6, B7MSV9, Escherichia coli, Escherichia coli, B1XDP7, C5A1D5, Escherichia coli, Escherichia coli, B5Z2F2, B7M804, Escherichia coli, Escherichia coli, B7NTK2, P0A6F7, Escherichia coli, Escherichia coli, B7LCO2, B7MKU8, Escherichia coli, Escherichia coli, B7UPW3, A7ZV12, Escherichia coli, Escherichia coli, A1AJ51, Q0T9P8, Escherichia coli, Escherichia coli, B3E8G0, A5U9V2, Escherichia coli, Escherichia coli, A5UH48, P43733, Escherichia coli, Escherichia coli, Q4QN05, B8F865, Escherichia coli, Escherichia coli, Q0I284, P31294, Escherichia coli, Geobacter lovleyi, Q9ZN50, B2UW12, Haemophilus influenzae, P42383, B6JPA7, Haemophilus influenzae, Q1CVE5, B5Z6D1, Haemophilus influenzae, Q17VC6, O66210, Haemophilus influenzae, B5Y368, A6TH53, Haemophilus parasuis, Haemophilus O66192, A0AKH5, somnus, Haemophilus ducreyi, Q9AGE6, Q71XU6, Helicobacter pylori, Helicobacter C1KX21, B8DH59, pylori, Helicobacter pylori, Q929V0, P48215, Helicobacter pylori, Helicobacter B4EXE2, Q4ZP20, pylori, Helicobacter pylori, Q48EI5, Q87X14, Helicobacter acinonychis, Klebsiella Q3K7L6, C3K1A0, oxytoca, Klebsiella pneumoniae, B0KFQ2, Q4K764, Klebsiella pneumoniae, Kluyvera A6VB57, B1J3K5, intermedia, Listeria welshimeri, A5W8M6, Q88N55, Listeria monocytogenes, Listeria Q02H55, P30718, monocytogenes, Listeria B7UZG3, Q8Y1P8, monocytogenes, Listeria O66214, O66212, monocytogenes, Listeria innocua, Q2KAU2, Q2JYW6, Neisseria flavescens, Proteus P35470, P35471, mirabilis, Pseudomonas syringae, Q1M3H2, Q9L691, Pseudomonas savastanoi, Q2KBZ7, P35469, Pseudomonas syringae, B5ZRD6, Q1MKX4, Pseudomonas fluorescens, Q2KAR0, Q930Y0, Pseudomonas fluorescens, Q9L690, P34939, Pseudomonas putida, Pseudomonas Q1MJF2, B2FIU9, fluorescens, Pseudomonas B4SKL8 aeruginosa, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Ralstonia solanacearum, Raoultella ornithinolytica, Raoultella planticola, Rhizobium etli, Rhizobium etli, Rhizobium meliloti, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium etli, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium etli, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium leguminosarum, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 58 AGEFTRRAF Sphingomonas wittichii A5VA82 Q969Y2 59 AGFSGHGFK Bacillus sp., Bacillus sp. P23342, P40859 Q9P0Z9 60 AGGQGTRLG Staphylococcus saprophyticus, Q49ZB5, Q4L846, Q16222 Staphylococcus haemolyticus, Q6GEQ8, Q7A0A0, Staphylococcus aureus, Q6G7E3, Q7A4A4, Staphylococcus aureus, Q99S95, Q2FEW1, Staphylococcus aureus, Q5HE34, Q2FW81, Staphylococcus aureus, Q2YYH4, Q5HM59, Staphylococcus aureus, Q8CNG6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 61 AGGRYDGLV Aeromonas salmonicida, Aeromonas A4SP01, A0KJ45, P12081 hydrophila, Enterobacter sp., A4WD92, B6I586, Escherichia coli, Escherichia coli, Q1R8L9, B1LNG9, Escherichia coli, Escherichia coli, P60906, B1IWE7, Escherichia coli, Escherichia coli, P60907, Q0TEX1, Escherichia coli, Escherichia coli, A1AE52, A8A320, Escherichia coli, Escherichia coli, B7M7L8, B1XAY9, Escherichia coli, Escherichia coli, C4ZX89, B7MYE9, Escherichia coli, Escherichia coli, B7NRG4, P60908, Escherichia coli, Escherichia coli, B5Z0Y3, B7MHZ9, Escherichia coli, Escherichia coli, A7ZPV7, B7LCQ4, Escherichia coli, Escherichia coli, B7UGW0, B7N6A2, Escherichia coli, Klebsiella B5XNL6, B4EZT2, pneumoniae, Proteus mirabilis, Q3K7B7, C3K1L3, Pseudomonas fluorescens, Q4ZX22, Q4K6V0, Pseudomonas fluorescens, Q88PJ6, B0KPI8, Pseudomonas syringae, A5VYT6, Q886Y9, Pseudomonas fluorescens, Q48LZ3, B1JDV7, Pseudomonas putida, Pseudomonas Q8DN46, B8ZPP6, putida, Pseudomonas putida, Q04I50, C1CU26, Pseudomonas syringae, A3CR40, C1CH52, Pseudomonas savastanoi, Q97NC9, B1I9T7, Pseudomonas putida, Streptococcus A8AZV0, B5E3C8, pneumoniae, Streptococcus C1CAV1, C1CNA0, pneumoniae, Streptococcus A4VT07, A4VZ92, pneumoniae, Streptococcus B2IN41, B9DW81, pneumoniae, Streptococcus Q3JYL6, P67486, sanguinis, Streptococcus P67485, C0MGD4 pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus suis, Streptococcus suis, Streptococcus pneumoniae, Streptococcus uberis, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus equi 62 AGGRYDGLVG Acinetobacter baumannii, B7I5G8, B0VKR7, P12081 Acinetobacter baumannii, B7H068, B0V5G6, Acinetobacter baumannii, Q6FEM2 Acinetobacter baumannii, Acinetobacter baylyi 63 AGGVTVSYFEW Bacillus subtilis, Bacillus subtilis P50735, P39633 P49448 64 AGIMITASHNPK Staphylococcus aureus, Q6GDU9, Q7A3K7, Q96G03 Staphylococcus aureus, Q99RE2, Q5HD61, Staphylococcus aureus, Q2FVC1, Q2FE11, Staphylococcus aureus, Q8NUV4, Q6G6I3, Staphylococcus aureus, Q2YW66, Q49WH7, Staphylococcus aureus, Q4L9R5 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus haemolyticus 65 AGKLHTGRSRND Lactobacillus reuteri, Lactobacillus A5VJH2, B2G6Y7 P04424 QV reuteri 66 AGLAVRDVSELTG Rhizobium loti Q98E57 P31939 FPE 67 AGLKEGDYI Bacillus subtilis O31754 Q8TCX5 68 AGNWTGEMVEE Aeromonas hydrophila, Aeromonas A0KN65, A4SJY8 P36959 LILSGADI salmonicida 69 AGTIAGLNV Campylobacter fetus, Helicobacter A0RPW7, P55994, P11021 pylori, Helicobacter pylori, B6JPL0, Q1CV46, Helicobacter pylori, Helicobacter B5Z9P0, B2URT8, pylori, Helicobacter pylori, Q9ZMW4 Helicobacter pylori 70 AGVMITASHN Lactobacillus reuteri, Lactobacillus B2G638, A5VIK4, Q6PCE3 reuteri, Lactobacillus brevis, Q03SJ3, Q03GV0 Pediococcus ntosaceus 71 AGVPRKPGM Methylobacterium sp., B0UCF0, B7KVX2, P40926 Methylobacterium extorquens, A9W386, B8IJB4, Methylobacterium extorquens, Q84FY8, B1LZN1, Methylobacterium nodulans, B1ZG93, Q9EYJ6, Methylobacterium extorquens, C3M9U0, B3PQ91, Methylobacterium radiotolerans, Q2K3E9 Methylobacterium populi, Rhizobium meliloti, Rhizobium sp., Rhizobium etli, Rhizobium etli 72 AGVTVVIVR Neisseria gonorrhoeae, Neisseria Q5F7A0, O34370, Q9Y617 meningitidis, Neisseria meningitidis, P57007, A1KV48 Neisseria meningitidis 73 AGVTVVIVRDDL Lactobacillus helveticus A8YW78 Q9Y617 74 AGYITPVPGGVGP Ralstonia pickettii B2UFY4 P13995 MT 75 AHGNSLRGI Bacteroides fragilis, Bacteroides Q5LAT7, Q64R85, P15259 fragilis, Bacteroides thetaiotaomicron, Q8A8R2, Q8A765 Bacteroides thetaiotaomicron 76 AHGTNPASA Uncultured termite B1GYV8 P23378 77 AHIDAGKTTTTER Aeromonas salmon icida A4SHV8 Q969S9 78 AHIDAGKTTTTERI Arcobacter butzleri, Neisseria A8EW86, Q9JX07, Q969S9 L meningitidis, Neisseria meningitidis, A1KRH0, A9M3X0, Neisseria meningitidis, Neisseria Q9K1I8, Q5F553, meningitidis, Neisseria gonorrhoeae, B4RQX2 Neisseria gonorrhoeae 79 AHLGHVFPDGP Escherichia coli, Escherichia coli, B7M1J2, B1IPF3, Q9Y3D2 Escherichia coli, Escherichia coli, A8A0X0, B7MVQ9, Escherichia coli, Escherichia coli, B6IBJ9, B1LDV3, Escherichia coli, Escherichia coli, B7N5B4, C4ZZD4, Escherichia coli, Escherichia coli, P0A746, Q0TH50, Escherichia coli, Escherichia coli, B7L603, P0A747, Escherichia coli, Escherichia coli, B1XGN8, B5YQ71, Escherichia coli, Escherichia coli, B7NSZ8, P0A748, Escherichia coli, Escherichia coli, B7USF8, A7ZMP8, Escherichia coli, Escherichia B7MAY9, B7LQ21, fergusonii, Klebsiella pneumoniae, B5XS71, A6T7R0, Klebsiella pneumoniae, B1J4W5, Q1ID16, Pseudomonas putida, Pseudomonas Q4ZQC6, Q4K8U5, entomophila, Pseudomonas syringae, B0KUQ0, C3K735, Pseudomonas fluorescens, Q885Q1, Q48FR2, Pseudomonas putida, Pseudomonas Q3K935, Q88LQ6, fluorescens, Pseudomonas syringae, A5W756, A4XVB1, Pseudomonas savastanoi, Q91016, Q02NZ0, Pseudomonas fluorescens, B7UUZ9, A6V3R3, Pseudomonas putida, Pseudomonas Q92RA4 putida, Pseudomonas mendocina, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Rhizobium meliloti 80 AHVDHGKTTL Bacillus subtilis, Escherichia coli, O07631, P32132, Q7Z2Z2 Escherichia coli, Escherichia coli, P0A3B3, P0A3B1, Escherichia coli, Haemophilus P0A3B2, P44910, influenzae, Helicobacter pylori, Q9ZLZ3, O25225 Helicobacter pylori 81 AIILATAGL Bacillus cytotoxicus A7GTE5 P08397 82 AIILATAGLQRMG Bacillus cereus, Bacillus cereus, B7JQ57, C1ETR0, P08397 W Bacillus thuringiensis, Bacillus A0RJ81, C3L6Z5, anthracis, Bacillus anthracis, Bacillus Q81LC7, C3P9E9, anthracis, Bacillus cereus, Bacillus Q72ZW2, Q6HD62, thuringiensis, Bacillus cereus, Bacillus B7IIX5, Q633Y0, cereus, Bacillus cereus, Bacillus Q817R0, B7HE96, cereus, Bacillus cereus, Bacillus B9IZ39, B7HQM4, cereus, Bacillus weihenstephanensis A9VIT8 83 AIKWNFTKF Bacillus subtilis P52035 P36969 84 AIVNAANSSL Fusobacterium nucleatum Q8RHQ2 Q9B069 85 AIYDTMQYI Desulfitobacterium hafniense, Q24S49, C4Z1T6, Q16740 Eubacterium eligens, Clostridium A7FYI2, A7GIH2, botulinum, Clostridium botulinum, B1IND7, C1FLA6, Clostridium botulinum, Clostridium A5I6W1, B9E685, botulinum, Clostridium botulinum, A5N2K8, B1L1D7, Clostridium kluyveri, Clostridium B2TPB9, B2UX13, kluyveri, Clostridium botulinum, A0Q2L1, Q891J7, Clostridium botulinum, Clostridium Q0ST53, Q8XKK1, botulinum, Clostridium novyi, Q0TQK2 Clostridium tetani, Clostridium perfringens, Clostridium perfringens, Clostridium perfringens 86 AKALALGAS Helicobacter pylori Q9ZL14 P12268 87 AKEMHVGHLRS Neisseria meningitidis, Neisseria Q9JYM8, A1KUU4, P54136 meningitidis, Neisseria meningitidis, Q9JTM7, B4RL22, Neisseria gonorrhoeae, Neisseria Q5F835, B1VTB7, gonorrhoeae, Streptomyces griseus, Q82E68, Q9WX29 Streptomyces avermitilis, Streptomyces coelicolor 88 AKEMHVGHLRSTII Pseudomonas entomophila, Q1IGB8, B1J2I3 P54136 G Pseudomonas putida 89 AKKVLSVAVYNHY Lactobacillus gasseri, Lactobacillus Q042T7, A8YUS4, O76031 KRI helveticus, Lactobacillus johnsonii Q74JU4 90 AKNTYGTGCF Bacillus weihenstephanensis, Bacillus A9VI58, Q6HMD5, Q14409 thuringiensis, Bacillus cereus, Bacillus B7HYU3, B7JCV9, cereus, Bacillus anthracis, Bacillus C3LCY4, Q63EX2, cereus, Bacillus cereus, Bacillus C1EKE4, A0RAP3, thuringiensis, Bacillus cytotoxicus, A7GLY7, B9IT52, Bacillus cereus, Bacillus anthracis, Q81U58, C3P2T3, Bacillus anthracis, Bacillus cereus, Q73CE0, Q9KDW8, Bacillus halodurans, Ralstonia B2UF87 pickettii 91 AKNTYGTGCFLL Eubacterium rectale, Clostridium C4ZGB4, B2TN12, Q14409 botulinum, Clostridium botulinum, B2V358, B8JOH2, Desulfovibrio desulfuricans, Q39V17, Q8Y6Z2, Geobacter metallireducens, Listeria B8DHL0, Q71ZD2, monocytogenes, Listeria C1KVI5, A0AIY7, monocytogenes, Listeria Q92BH6 monocytogenes, Listeria monocytogenes, Listeria welshimeri, Listeria innocua 92 AKRLCPQLI Bacillus cereus, Bacillus anthracis Q635E0, Q81M86 Q9UBT6 93 ALAAGNCVV Citrobacter koseri, Enterobacter sp. A8AGJ9, A4WAR9 P43353 94 ALAAGNCVVLKPS Escherichia coli, Escherichia coli, B6IAI9, B7LZ33, P43353 EI Escherichia coli, Escherichia coli, A7ZLN7, B1IS15, Escherichia coli, Escherichia coli, A8A002, B7URJ0, Escherichia coli, Escherichia coli, P77674, B1XDF5, Escherichia coli, Escherichia coli, C4ZVI3, Q1RBX3, Escherichia coli, Escherichia coli, Q8FHK7, Q0THX6, Escherichia coli, Escherichia coli, A1AB46, B7MUN0, Escherichia coli, Escherichia coli, B7MMS8, B1LFH3, Escherichia coli, Escherichia B7L6F9, B7LR95, fergusonii, Escherichia coli, B7N4K1, B5Z0W0, Escherichia coli, Escherichia coli Q8X9W5 95 ALAAIFIAQ Bacillus caldotenax P24944 P43003 96 ALEKIRAGA Rhizobium leguminosarum, B5ZPH6, Q1MLT8, Q02127 Rhizobium leguminosarum, B3PNN8, Q2KCS8 Rhizobium etli, Rhizobium etli 97 ALEYGLPPT Fusobacterium nucleatum Q8RG52 Q15046 98 ALEYGLPPTAG Acinetobacter baumannii, B0VSE0, B0V9L5, Q15046 Acinetobacter baumannii, B7GXW0, A3M3D6, Acinetobacter baumannii, Q43990 Acinetobacter baumannii, Acinetobacter baylyi 99 ALFGTIDSWL Methylobacterium extorquens, B7KN92, A9W8T7, Q14409 Methylobacterium extorquens, B1ZGW7 Methylobacterium populi 100 ALGSDTGGS Lactobacillus plantarum, Eubacterium Q88XP7, C4ZHB9 Q9H0R6 rectale 101 ALKAADVGI Bacillus subtilis O31688 Q9NQ11 102 ALKPMNCPGH Ralstonia pickettii, Stenotrophomonas B2UGJ8, B4SQH4 A2RTX5 maltophilia 103 ALKYHPDKN Clostridium tetani Q892R1 O75953 104 ALQTREQHI Bacteroides thetaiotaomicron, Q8A8M0, Q5LDN2, P23378 Bacteroides fragilis, Bacteroides Q64UQ7 fragilis 105 ALQTREQHIRR Pseudomonas stutzeri, Pseudomonas A4VRT4, Q88CI9 P23378 putida 106 ALREAQEEV Citrobacter koseri, Enterobacter A8AFP5, P43338, P00O24 aerogenes, Klebsiella pneumoniae, B5XQ60, A6TAY4 Klebsiella pneumoniae 107 ALRNRSNTP Haemophilus parasuis, Proteus B8F632, B4EYR8, P06744 mirabilis, Rhizobium etli, Rhizobium Q2KCY8, B3Q0A9, etli, Rhizobium leguminosarum B5ZNS9 108 ALRNRSNTPI Edwardsiella ictaluri C5B6Z1 P06744 109 ALVGPNGAGKS Streptomyces coelicolor Q9RKQ4 Q9UG63 110 ALVTGASGGIG Rhizobium sp. P72332 Q6UWP2 111 AMEGPTPVSAL Streptomyces coelicolor Q9XAR5 P03915 112 AMLACARIGA Pseudomonas syringae, Q885K7, Q4ZQG8, Q9NUB1 Pseudomonas syringae, Q48G09, Q88EH6, Pseudomonas savastanoi, A4VKA0, C3MAS0, Pseudomonas putida, Pseudomonas Q92KX2, Q82EL5 stutzeri, Rhizobium sp., Rhizobium meliloti, Streptomyces avermitilis 113 AMLACARIGAVH Citrobacter koseri, Escherichia coli, A8AN29, Q8FAY8, Q9NUB1 Escherichia coli, Escherichia coli, Q8X5T5, P27550, Pseudomonas aeruginosa, Rhizobium Q9HV66, B3PS41, etli, Rhizobium leguminosarum, B5ZV36, Q2K2T1 Rhizobium etli 114 AMLTTFNEIDM Staphylococcus saprophyticus Q49XM4 P36957 115 AMVGDGIND Bacillus subtilis O32220 Q04656 116 ANASLLDEGTAAA Akkermansia muciniphila, B2UNH4, Q4K7Q8 P23378 EA Pseudomonas fluorescens 117 ANDPDADRLAVA Haemophilus influenzae Q57290 Q96G03 118 ANFAVYTAL Citrobacter koseri, Edwardsiella A8AD38, C5BEV2, P34896 ictaluri, Enterobacter sp., Escherichia A4WDC0, B1LNK7, coli, Escherichia coli, Escherichia coli, Q1R814, B6I5C4, Escherichia coli, Escherichia coli, P0A825, A8A359, Escherichia coli, Escherichia coli, B1IV56, P0A826, Escherichia coli, Escherichia coli, Q0TET8, B1X1326, Escherichia coli, Escherichia coli, A1AE82, C4ZXC6, Escherichia coli, Escherichia coli, B7M8A7, B7MYI0, Escherichia coli, Escherichia coli, B7NRK2, B7LDE3, Escherichia coli, Escherichia coli, B7MIN5, A7ZPZ4, Escherichia coli, Escherichia coli, B7UGZ1, B5Z123, Escherichia coli, Escherichia coli, Q8XA55, B7N6D8, Klebsiella pneumoniae, Klebsiella A6TCG5, B5XNI6 pneumoniae 119 ANFLDVGGGA Campylobacter hominis A7I2F2 Q9P2R7 120 ANGPTTPEA Staphylococcus aureus, Q7A1B9, Q6GID0, P49448 Staphylococcus aureus, Q6GAW8, Q99VD0, Staphylococcus aureus, Q7A6H8, Q5HHC7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 121 ANGPTTPEAD ptoclostridium difficile P27346 P49448 122 ANMDTVGTF Edwardsiella ictaluri, Enterobacter C5B9H0, A4W6K6, P36959 sp., Escherichia coli, Escherichia coli, Q8X984, B5YZD9, Escherichia coli, Escherichia coli, A7ZHJ5, Q0TLN6, Escherichia coli, Escherichia coli, B7M145, Q1RG92, Escherichia coli, Escherichia coli, B6HZ81, P60560, Escherichia coli, Escherichia coli, B1IQN5, P60561, Escherichia coli, Escherichia coli, B1XC80, C4ZRJ8, Escherichia coli, Escherichia coli, A7ZW55, A1A7E7, Escherichia coli, Escherichia coli, B7MAM6, B7LFX2, Escherichia coli, Escherichia coli, B7UIF3, B7N7X5, Escherichia coli, Escherichia coli, B7NI65, B7MNW1, Escherichia coli, Escherichia B1LG40, B7LWQ6, fergusonii, Klebsiella pneumoniae, B5Y1T3, A6T4P6 Klebsiella pneumoniae 123 ANMDTVGTFEMA Citrobacter koseri A8ALJ2 P36959 124 APALACGNA Pseudomonas sp. Q9KWS5 P49189 125 APGRVNLIGEHTD Aeromonas hydrophila, Bacillus A0KQH8, P39574, P51570 YN subtilis, Bacillus halodurans, Q9KDV4, A8AJ37, Citrobacter koseri, Enterobacter sp., A4W899, B7MPP1, Escherichia coli, Escherichia coli, B1LM48, B7N9Z9, Escherichia coli, Escherichia coli, B7ULN0, B7LK02, Escherichia fergusonii, Escherichia B617R1, P0A6T3, coli, Escherichia coli, Escherichia coli, B1IXX9, C4ZXS8, Escherichia coli, Escherichia coli, B7M6C0, B5YRF5, Escherichia coli, Escherichia coli, P0A6T4, B7LAF8, Escherichia coli, Escherichia coli, A7ZJD2, B7NNH9, Escherichia coli, Escherichia coli, Q1REH4, Q8FJS1, Escherichia coli, Escherichia coli, Q0TJU4, A1A900, Escherichia coli, Escherichia coli, B7MGL4, A7ZY13, Escherichia coli, Proteus mirabilis, B4F0A6, Q9K3S8 Streptomyces coelicolor 126 APGTGTPEI Pseudomonas aeruginosa Q9I6K2 Q9BSE5 127 APIFHVNADDPEA Escherichia coli, Escherichia coli, P0AFG3, P0AFG5, Q9ULD0 V Escherichia coli P0AFG4 128 APSDMMDGR Clostridium josui Q59295 P13716 129 APSPTGFLH Lactobacillus reuteri, Lactobacillus B2G868, A5VKT4, Q5JPH6 reuteri, Listeria monocytogenes, Q724H5, Q8YAB3, Listeria monocytogenes, Listeria A0AF36, Q92F38 welshimeri, Listeria innocua 130 APTGSGKTLA Escherichia coli P30015 Q9Y2R4 131 APTRELAQQ Bacillus cereus, Staphylococcus Q818H2, Q2FY15 Q92841 aureus 132 AQEALGDVV Pseudomonas aeruginosa, Q9HTX6, Q88CI8, P23434 Pseudomonas putida, Pseudomonas Q88AR9 syringae 133 AQLSGGQKQR Pseudomonas aeruginosa, Q02ME3, Q9I1C8, Q2M3G0 Pseudomonas aeruginosa, Q4KK46, Q3KJS6, Pseudomonas fluorescens, Q87UN4, Q4ZZR8, Pseudomonas fluorescens, Q48PU6, Q827Y0 Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi, Streptomyces avermitilis 134 AQLSGGQKQRV Pseudomonas savastanoi, Q48PN3, Q3KK97, Q9NP78 Pseudomonas fluorescens, Q4ZZK0, Q87UV4, Pseudomonas syringae, Q9L1C3 Pseudomonas syringae, Streptomyces coelicolor 135 AQSIGEPGTQ Desulfovibrio alaskensis, Q30X04, A1VAJ5, O14802 Desulfovibrio vulgaris, Desulfovibrio Q727C6, B3E7S9, vulgaris, Geobacter lovleyi, Geobacter B5EFP4, C6E4R3, bemidjiensis, Geobacter sp., B9M6V1, A5GAY2, Geobacter daltonii, Geobacter Q40N34, A5U9X9, uraniireducens, Haemophilus A5UH19, P43739, influenzae, Haemophilus influenzae, Q7VKL8, Q8XUZ9, Haemophilus influenzae, B2FQ39 Haemophilus influenzae, Haemophilus ducreyi, Ralstonia solanacearum, Stenotrophomonas maltophilia 136 ARGLDYYTG Bifidobacterium longum, B7GPS9, Q8G864, P12081 Bifidobacterium longum, B8DU04, Q892X7, ifidobacterium animalis, Clostridium B2FPL6, B4STN3 tetani, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 137 ARLNFSHGSHE Staphylococcus aureus, Q6GG09, Q7A0N4, P30613 Staphylococcus aureus, Q5HF76, Q6G8M9, Staphylococcus aureus, Q2FXM9, Q99TG5, Staphylococcus aureus, Q7A559, Q2FG40, Staphylococcus aureus, Q2YTE3, Q8CS69, Staphylococcus aureus, Q5HNK7, Q4L739 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus 138 ARMTAMDNA Clostridium cellulolyticum B81578 P36542 139 ARVYKQSDL Campylobacter fetus A0RR73 P00480 140 ASFITPVPGGVGP Bacillus methylotrophicus, Bacillus A7Z6J9, P54382 P11586 MT subtilis 141 ASFITPVPGGVGP Aeromonas hydrophila, Aeromonas A0KJD4, A4SNM0 P11586 MTVA salmonicida 142 ASFITPVPGGVGP Haemophilus somnus Q0I3S5 P11586 TVAMLM 143 ASGAGGQHVN Enterococcus faecalis Q831F6 Q9UGC7 144 ASGPLVRSSY Pseudomonas fluorescens, C3K2L8, A6V0B4, O43766 Pseudomonas aeruginosa, B1J144, Q3K6A4, Pseudomonas putida, Pseudomonas Q1I4G1, B7V9C1, fluorescens, Pseudomonas Q9HX25, Q02SG3, entomophila, Pseudomonas Q88DM5, A5W9I5, aeruginosa, Pseudomonas Q87WV7, Q4ZN84, aeruginosa, Pseudomonas Q48DM6, A4VQZ6 aeruginosa, Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi, Pseudomonas stutzeri 145 ASKNASEMI Geobacter lovleyi B3EA02 P36542 146 ASKPLKGARI Rhizobium meliloti Q92TC1 P23526 147 ASLLDEGTAAAEA Streptomyces avermitilis, Q827D7, Q9AK84, P23378 Streptomyces coelicolor, B1W4G3 Streptomyces griseus 148 ASLVHDDVIDDA Bacillus subtilis P31114 Q5T2R2 149 ATDIAARGLD Bacillus subtilis O34750 Q13206 150 ATDPDADRL Bacillus subtilis P18159 Q6PCE3 151 ATDVAARGLDI Staphylococcus aureus, Q6GEZ3, Q7A0D2, Q9GZR7 Staphylococcus aureus, Q6G7M9, Q5HEB9, Staphylococcus aureus, Q7A4G0, Q995H6, Staphylococcus aureus, Q2FF45, Q2FWH5, Staphylococcus aureus, Q2YUH3, Q8CRP6, Staphylococcus aureus, Q4L7W0, Q5HME0, Staphylococcus aureus, Q49Z29 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus saprophyticus 152 ATIAFGMGI Haemophilus influenzae P71359 P54132 153 ATINYPFEKGP Rhizobium etli, Rhizobium Q2K954, Q1MIK6, O00217 leguminosarum, Rhizobium B5ZYM2 leguminosarum 154 ATIQVYEETSG Clostridium tetani Q891P1 P38606 155 ATPKGYEPDA Campylobacter curvus A7GZL8 P00480 156 ATSGDTGSA Pseudomonas aeruginosa P29363 Q81Y07 157 ATVKGDVHDIGKN Haemophilus influenzae Q57195 Q99707 IV 158 ATWQKLLD Neisseria meningitidis Q9JTZ5 Q9H0R6 159 ATWCGPCKMI Staphylococcus aureus, Q6GA69, Q6GHU0, P10599 Staphylococcus aureus, P0A0K5, P0A0K6, Staphylococcus aureus, P99122, P0A0K4, Staphylococcus aureus, Q5HGT9, Q2YXD0, Staphylococcus aureus, Q2FZD2, Q2FHT6, Staphylococcus aureus, Q8CPL5, Q5HQ29, Staphylococcus aureus, Q49WR2, Q4L5F0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus haemolyticus 160 AVDTTGAGD Klebsiella pneumoniae P26420 Q9H477 161 AVGIDLGTT Bifidobacterium longum, Q8G6W1, B3DNP9, P11142 Bifidobacterium longum, B8DT62 Bifidobacterium animalis 162 AVGKIVMEAAAK Bacillus subtilis P39616 P51648 163 AVGQGALGVE Clostridium acetobutylicum Q97MU4 P08397 164 AVGSDADIV Rhizobium radiobacter Q44184 Q14117 165 AVIHFAGLKAVGE Klebsiella pneumoniae P45602 Q14376 SV 166 AVITVPAYF Corynebacterium efficiens, Q8FM78, C3PJM6, P0DMV9 Corynebacterium aurimucosum, B0S1F8, Q03FR7 Finegoldia magna, Pediococcus ntosaceus 167 AVITVPAYFND Bacillus cytotoxicus, Bacillus cereus, A7GT08, Q730M1, P0DMV9 Bacillus cereus, Bacillus cereus, B9IY81, B7HPL3, Bacillus thuringiensis, Bacillus cereus, Q6HDK7, Q634M7, Bacillus cereus, Bacillus cereus, Q818E9, B7HCU0, Bacillus anthracis, Bacillus cereus, C3L5R7, C1ESK8, Bacillus anthracis, Bacillus Q81L52, A0RIT3, thuringiensis, Bacillus cereus, Bacillus B7JN39, C3P8M0, anthracis, Bacillus cereus, Bacillus B7IYG7, A9VHU1, weihenstephanensis, Bacillus P05646, A8FFD2, megaterium, Bacillus pumilus, Q4JXX6, Q826F6 Corynebacterium jeikeium, Streptomyces avermitilis 168 AVITVPAYFNDSQ Campylobacter hominis A7I2D4 P17066 R 169 AVITVPAYFNDSQ Lactobacillus casei, Lactobacillus Q038N3, B3WEQ7 P0DMV9 RQATKDAG casei 170 AWSLLDNFEW Paenibacillus polymyxa P22073 Q9H227 171 AWTTTPWTLP Clostridium kluyveri A5N3P1 P41252 172 AWTTTPWTLPSN Bacteroides fragilis, Bacteroides Q64U07, Q5LCU8, P41252 fragilis, Bacteroides thetaiotaomicron, Q8A9K9, A0Q3B0, Clostridium novyi, Clostridium tetani, Q899C3, Q8XHE4, Clostridium perfringens, Clostridium Q97E50, Q7MUD3 acetobutylicum, Porphyromonas gingivalis 173 AWTTTPWTLPSNL Corynebacterium efficiens, Q8FNV0, Q8NNP0 P41252 A Corynebacterium glutamicum 174 AYEIIKLKG Lactobacillus casei P00343 P07864 175 AYEPVWAIG Pseudomonas stutzeri A4VPP4 P60174 176 AYEPVWAIGTG Bifidobacterium longum, B3DRW0, Q8G6D5, P60174 Bifidobacterium longum, A1A1N2, B0KHY2, Bifidobacterium adolescentis, Q88DV4, A5W991, Pseudomonas putida, Pseudomonas Q3KI88, Q1IF47, putida, Pseudomonas putida, Q4KIF9, A6VCK5, Pseudomonas fluorescens, B1J266, B7V1G0, Pseudomonas entomophila, Q9HV51, Q02FS4, Pseudomonas fluorescens, Q87WQ1, Q48E73, Pseudomonas aeruginosa, P95576, A4XYE4, Pseudomonas putida, Pseudomonas Q92QA1, Q98ME7, aeruginosa, Pseudomonas B4SQT8, B2FNY1 aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas mendocina, Rhizobium meliloti, Rhizobium loti, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 177 AYEPVWAIGTGK Corynebacterium glutamicum, A4QEG0, Q8FT67, P60174 Corynebacterium efficiens, P19583, Q6NH37, Corynebacterium glutamicum, B8DJI3, A4WG77, Corynebacterium diphtheriae, Q9Z6B9, B7NFL6, Desulfovibrio vulgaris, Enterobacter B7LVC6, P0A860, sp., Enterobacter cloacae, B7M6X0, B6I4R2, Escherichia coli, Escherichia A7ZUD3, Q1R3Z9, fergusonii, Escherichia coli, Q0TAE5, A8A724, Escherichia coli, Escherichia coli, B1LNM2, B1X1385, Escherichia coli, Escherichia coli, P0A859, P0A858, Escherichia coli, Escherichia coli, B1IVG0, A1AI95, Escherichia coli, Escherichia coli, B5YZ57, B7NU88, Escherichia coli, Escherichia coli, B7MI51, B5EF41, Escherichia coli, Escherichia coli, Q7X222, Q9JW31, Escherichia coli, Escherichia coli, Q9JXT8, Q9Z520, Escherichia coli, Geobacter Q829W1 bemidjiensis, Klebsiella pneumoniae, Neisseria meningitidis, Neisseria meningitidis, Streptomyces coelicolor, Streptomyces avermitilis 178 AYEPVWAIGTGKT Geobacter lovleyi B3E9Q8 P60174 A 179 AYEPVWAIGTGKT Geobacter uraniireducens, Ralstonia A5G381, Q8XXP9 P60174 AT solanacearum 180 AYEPVWAIGTGKT Fusobacterium nucleatum, Uncultured Q8RDX7, B1GZW3 P60174 ATP termite 181 AYEVLSDPQ Clostridium thermocellum, A3DF24, Q835R5, Q9NVH1 Enterococcus faecalis, Geobacter Q74H58, B4F2V6, sulfurreducens, Proteus mirabilis, Q9RDD7, Q82BY4, Streptomyces coelicolor, O52164 Streptomyces avermitilis, Streptomyces albus 182 AYNADFDGD Aeromonas salmonicida, Aeromonas A4SHV0, A0KQA4, O95602 hydrophila, Akkermansia muciniphila, B2UQY1, B2GDX6, Lactobacillus fermentum, Q1WVA4, A5VLL3, Lactobacillus salivarius, Lactobacillus B2G8Y5, Q88XZ2, reuteri, Lactobacillus reuteri, Q03PV0, A8F977, Lactobacillus plantarum, Lactobacillus A8YXJ9, A7ZON0, brevis, Bacillus pumilus, Lactobacillus Q5WLR9, A9VP70, helveticus, Bacillus methylotrophicus, Q5FM96, B3WAM7, Bacillus clausii, Bacillus P77819, Q034X1, weihenstephanensis, Lactobacillus P37871, A7GK13, acidophilus, Lactobacillus casei, Q9Z9M1, Q73FA3, Bacillus anthracis, Lactobacillus Q63H97, Q6HPR5, casei, Bacillus subtilis, Bacillus A0R8H3, Q81J47, cytotoxicus, Bacillus halodurans, Q38UQ3, Q65PB4, Bacillus cereus, Bacillus cereus, Q046D1, Q74L94, Bacillus thuringiensis, Bacillus Q04C21, Q1GBM4, thuringiensis, Bacillus cereus, Q250N9, A8AKT8, Lactobacillus sakei, Bacillus A3DIZ5, B1IGG1, licheniformis, Lactobacillus gasseri, A5I7L3, A7FZ76, Lactobacillus johnsonii, Lactobacillus B1KSN2, Q18CF3, delbrueckii, Lactobacillus delbrueckii, A7GJ81, A5N4P0, Desulfitobacterium hafniense, Q890N5, A0PXT9, Citrobacter koseri, Clostridium Q97EH0, A6LPQ5, thermocellum, Clostridium botulinum, B2TIG9, B2UYA4, Clostridium botulinum, Clostridium A4W5A8, Q82Z41, botulinum, Clostridium botulinum, Q0TA77, B1IU0Q, ptoclostridium difficile, Clostridium P0A8T7, A8A787, botulinum, Clostridium kluyveri, P0A8T8, B1XBZ0, Clostridium tetani, Clostridium novyi, A7ZUK2, B1LNU0, Clostridium acetobutylicum, Q1R5V4, A1AIG0, Clostridium beijerinckii, Clostridium Q8FB83, B0S2E5, botulinum, Clostridium botulinum, A6TGP1, P94892, Enterobacter sp., Enterococcus P94899, B1MWV7, faecalis, Escherichia coli, Escherichia P77879, Q724E9, coli, Escherichia coli, Escherichia coli, Q8YA96, A0AF64, Escherichia coli, Escherichia coli, P77882, P77917, Escherichia coli, Escherichia coli, Q03EB0, Q02T86, Escherichia coli, Escherichia coli, Q9HWC9, A6UZI2, Escherichia coli, Finegoldia magna, A4VHM4, A4XZ96, Klebsiella pneumoniae, Leuconostoc C3K2Y2, P0C1T4, mesenteroides, Leuconostoc P60286, Q6GBU4, pseudomesenteroides, Leuconostoc P60285, P60284, citreum, Listeria innocua, Listeria Q2G0N5, Q5HID2, monocytogenes, Listeria Q6GJC5, Q2YSB8, monocytogenes, Listeria welshimeri, Q2FJ97, Q4L3K4, Listeria grayi, Pediococcus Q8C083, Q5HRK9, acidilactici, Pediococcus ntosaceus, Q49V53, Q8DS47, Pseudomonas aeruginosa, C0M7R5, B8ZNW6, Pseudomonas aeruginosa, Q04IK7, Q8DNF1, Pseudomonas aeruginosa, A3CKD4, C1CMQ7, Pseudomonas stutzeri, Pseudomonas B5E2F2, C1CTL3, mendocina, Pseudomonas C1CGP3, B2IM39, fluorescens, Staphylococcus aureus, Q97N08, B1I8R3, Staphylococcus aureus, C1CA05, A8AZI2, Staphylococcus aureus, A4VSK3, A4VYU4, Staphylococcus aureus, Q8E238, Q8E7J7, Staphylococcus aureus, Q3K3L1, C0MEE4, Staphylococcus aureus, P0C0E0, Q48VR0, Staphylococcus aureus, A2RC52, Q5XE96, Staphylococcus aureus, P0DF33, Q1J8X0, Staphylococcus aureus, Q8P2Y2, Q1JJ22, Staphylococcus aureus, Q1JNX6, Q1JE19, Staphylococcus haemolyticus, P0DF32, B9DSZ6, Staphylococcus epidermidis, Q5M2F6, Q5LXV4, Staphylococcus epidermidis, Q03IK3, P96177, Staphylococcus saprophyticus, P96178 Streptococcus mutans, Streptococcus equi, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus gordonii, Streptococcus suis, Streptococcus suis, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus uberis, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Weissella hellenica, Weissella paramesenteroides 183 AYSGGLDTS Uncultured termite B1H0L3 P00966 184 CAAPGGKTTHI Haemophilus ducreyi, Haemophilus Q7VKC4, P44788 Q8TEA1 influenzae 185 CEAHLGHVF Acinetobacter baumannii, B2HYT2, A3M4Q3, Q9Y3D2 Acinetobacter baumannii, B7I415, B0VC45, Acinetobacter baumannii, B7H3X2, B0VR86 Acinetobacter baumannii, Acinetobacter baumannii, Acinetobacter baumannii 186 CEHHLVPFVG Streptomyces avermitilis Q82EE8 P30793 187 CETDFVSRN Desulfovibrio vulgaris, Desulfovibrio A1VFA9, Q72DQ6 P43897 vulgaris 188 CGNTVVVKP Pseudomonas sp., Pseudomonas P19059, P86808 P00352 putida 189 CGSGVTACH Pseudomonas aeruginosa Q9I452 P25325 190 CIFEYVYFARPDS Haemophilus influenzae P43854 Q06203 191 CIGEKLDEREAG Desulfovibrio vulgaris, Desulfovibrio Q72BF9, A1VDB2 P60174 vulgaris 192 CIRAGGKHNDL Helicobacter hepaticus Q7VHV4 P49588 193 CIRAGGKHNDLD Campylobacter fetus, Campylobacter A0RPR0, A8FKT2, P49588 jejuni, Campylobacter jejuni, Q9PI05, Q5HVQ7, Campylobacter jejuni, Campylobacter A7ZE62, A7H4N3, concisus, Campylobacter jejuni, A7GZA4, A7I206 Campylobacter curvus, Campylobacter hominis 194 CLLTPGHTAG Bacillus subtilis O34769 Q6P1I5 195 CLNVGCIPSK Corynebacterium glutamicum Q8NTE1 P09622 196 CLNVGCIPSKALL Escherichia coli, Escherichia coli, P0A9P1, P0A9P0, P09622 Escherichia coli, Haemophilus P0A9P2, P43784 influenzae 197 CLSVNDAFV Rhizobium sp., Rhizobium etli Q53212, O69777 P30044 198 CNALETLLIH Campylobacter jejuni, Campylobacter A1VYR7, P53000, P54886 jejuni, Geobacter lovleyi, Geobacter B3E3M7, A5G906, uraniireducens, Geobacter Q39QR2, B9M0D6, metallireducens, Geobacter daltonii, C6E7L9, B5EEI4 Geobacter sp., Geobacter bemidjiensis 199 CNAYTELNDP Clostridium tetani Q899G7 Q15046 200 CNRLRITADG Lactobacillus plantarum, Lactobacillus Q88WY1, B2GCN4 Q9NZB8 fermentum 201 CPVDAIVEG Clostridium sp. P00197 O00217 202 CPWGKGRPGWH Clostridium novyi A0PXS5 P49589 203 CRMCLVEIE Rhizobium meliloti P56914 P28331 204 DADLINAGKET Bacillus subtilis, Helicobacter pylori, P42316, P56007, P55809 Helicobacter pylori Q9ZLE4 205 DAFGLPAEN Clostridium perfringens, Clostridium Q8XML8, Q0SV78, Q15031 perfringens, Clostridium perfringens, Q0TTD0, A0PYK3, Clostridium novyi, Clostridium A5N399, A7G9T9 kluyveri, Clostridium botulinum 206 DAFGTAHRA Acinetobacter baumannii, B2HZB6, B71501, P07205 Acinetobacter baumannii, B0VD03, B7H3N8, Acinetobacter baumannii, B0VMX3, A3M4X6, Acinetobacter baumannii, Q6FB08, A0KGD3, Acinetobacter baumannii, A4SRF1, A4XPG4, Acinetobacter baumannii, B7V4D9, Q9I5Y4, Acinetobacter baylyi, Aeromonas Q02TL3, A6UZ15, hydrophila, Aeromonas salmonicida, C3K3F1, Q3K5F2, Pseudomonas mendocina, Q4K4J1, Q113Y0, Pseudomonas aeruginosa, B1J302, B0KLY7, Pseudomonas aeruginosa, Q88D64, A5W9Z6, Pseudomonas aeruginosa, B2FSF3, B4STV2 Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 207 DAGKTTTTERILYY Enterococcus faecalis, Streptococcus Q839G9, B5XJR1, Q969S9 pyogenes, Streptococcus uberis, B9DVS2, P0DA85, Streptococcus pyogenes, Q48VB6, Q1J8I4, Streptococcus pyogenes, Q1JIM6, Q1JNH7, Streptococcus pyogenes, P69948, Q5XDW4, Streptococcus pyogenes, P0DA84, P69946, Streptococcus pyogenes, C0MF25, C0M937, Streptococcus pyogenes, B4U0V9, A2RCI2 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus equi, Streptococcus equi, Streptococcus equi, Streptococcus pyogenes 208 DAIVNAANS Ralstonia solanacearum, Q8Y2K1, Q8NYB7, Q9B069 Staphylococcus aureus, Q6GCE6, Q6GJZ1, Staphylococcus aureus, P67343, P67344, Staphylococcus aureus, Q5HIW9 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 209 DAIVNAANSSLLG Streptomyces coelicolor Q9ZBG3 Q9B069 GGGVDG 210 DAKINFDDNA Geobacter sulfurreducens, Q74EA5, Q4L5U8, Q96199 Staphylococcus haemolyticus, B9DPG0, Q6GHJ0, Staphylococcus carnosus, P66872, Q6G9W8, Staphylococcus aureus, A8Z355, Q5HGI7, Staphylococcus aureus, P99071, P66871, Staphylococcus aureus, A6QGE5, A5ISD0, Staphylococcus aureus, Q2FZ37, Q2FHJ3, Staphylococcus aureus, A6U164, A7X1L8, Staphylococcus aureus, Q2YXM1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 211 DALSSMANI Haemophilus influenzae P43842 Q13423 212 DALSSMANIAGY Escherichia coli P07001 Q13423 213 DAPVSGGVG Pseudomonas aeruginosa P28811 P31937 214 DAQRQATKD Clostridium cellulolyticum B8I305 P11021 215 DAQRQATKDAG ptoclostridium difficile, Q182E8, C4LGV8 P11021 Corynebacterium kropnstedtii 216 DAQRQATKDAGTI Desulfitobacterium hafniense B8FUN4 P11021 AGL 217 DAVGMSTVPEVIV Bacillus subtilis P46354 P00491 A 218 DCPGHADYVKNMI Helicobacter pylori Q9ZK19 P49411 TG 219 DDITHPIPDLTG Geobacter uraniireducens A5GCR3 P15313 220 DDLLATGGT Lactobacillus plantarum, Lactobacillus Q88VH0, Q038P1, P07741 Qcasei, Lactobacillus brevis, Q3QP8, Q38W53, Lactobacillus sakei, Lactobacillus Q1WT53, Q5WHQ1, salivarius, Bacillus clausii, Bacillus Q9KDH2, A8FFQ0, halodurans, Bacillus pumilus, Bacillus A7GT90, Q65G08, cytotoxicus, Bacillus licheniformis, Q34443, B7HE42, Bacillus subtilis, Bacillus cereus, Q634D6, Q817X3, Bacillus cereus, Bacillus cereus, B711S0, Q730C4, Bacillus cereus, Bacillus cereus, Q81LI1, Q6HDB8, Bacillus anthracis, Bacillus B7HQG7, A0RJ16, thuringiensis, Bacillus cereus, Bacillus C3L613, C3P995, thuringiensis, Bacillus anthracis, B9IYY2, B7JPZ4, Bacillus anthracis, Bacillus cereus, Q892A7, C4XU70, Bacillus cereus, Clostridium tetani, Q834G6, A5UBP3, Desulfovibrio maeticus, Enterococcus P43856, Q4QJV7, faecalis, Haemophilus influenzae, A5UF74, Q0I3U5, Haemophilus influenzae, O25296, Q1CTV4, Haemophilus influenzae, B2UTQ6, B6JLF4, Haemophilus influenzae, B5Z6U3, Q17W08, Haemophilus somnus, Helicobacter A0AIX3, C1KVH1, pylori, Helicobacter pylori, Q71ZE6, B8DHM4, Helicobacter pylori, Helicobacter P0A2X6, P0A2X5, pylori, Helicobacter pylori, Q03F39 Helicobacter acinonychis, Listeria welshimeri, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria innocua, Listeria monocytogenes, Pediococcus ntosaceus 221 DDLLATGGTM Bacteroides fragilis, Bacteroides Q5LIY6, Q650H6, P07741 fragilis, Geobacter lovleyi, Geobacter B3E683, A5G4S5, uraniireducens, Geobacter daltonii, B9M4Z1, B5EHF2, Geobacter bemidjiensis, Geobacter C6E585 sp. 222 DDNEETIKKRL Bacteroides thetaiotaomicron, Q89ZJ0, A6L0Z9, P00568 Bacteroides vulgatus, Bacteroides Q64XA6, Q5LGH0 fragilis, Bacteroides fragilis 223 DEELKKAYR Stenotrophomonas maltophilia B4SSQ7 Q9H819 224 DEIKKAYRK Acinetobacter baumannii, B0VA24, A3MA88, O75953 Acinetobacter baumannii, B0VQ00, B212G6, Acinetobacter baumannii, B7I2B2, B7GV08, Acinetobacter baumannii, Q6F6R1, A7Z6W0, Acinetobacter baumannii, A8FFD1, Q65H55, Acinetobacter baumannii, P17631, Q88VM1, Acinetobacter baylyi, Bacillus Q03QU2, Q8G6C6, methylotrophicus, Bacillus pumilus, A0Q1R3, B8DE39, Bacillus licheniformis, Bacillus subtilis, Q92BN9, P0DJM1, Lactobacillus plantarum, Lactobacillus G2K045, Q71ZJ8, brevis, Bifidobacterium longum, C1KVB9, A0AIS3, Clostridium novyi, Listeria A1KR91, P63969, monocytogenes, Listeria innocua, P63968, A9LZV9, Listeria monocytogenes, Listeria Q5F5M1, Q8XW41, monocytogenes, Listeria B2UBP2, Q2YT48, monocytogenes, Listeria P63972, A8Z4B8, monocytogenes, Listeria welshimeri, Q6G8Y8, P63971, Neisseria meningitidis, Neisseria P63970, A6QHC2, meningitidis, Neisseria meningitidis, Q5HFI1, A5ITA7, Neisseria meningitidis, Neisseria Q2FXZ3, Q2FGE4, gonorrhoeae, Ralstonia A6U251, A7X2Y0, solanacearum, Ralstonia pickettii, Q6GGC1, P45555, Staphylococcus aureus, Q8CVVT2, P95830 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pneumoniae 225 DEIKKAYRKM Streptococcus uberis B9DVF2 O75953 226 DELGRGTAT Leuconostoc citreum, Leuconostoc B1N025, Q03VV4 P52701 mesenteroides 227 DELGRGTSTYDG Bacteroides fragilis, Bacteroides Q64MG7, Q5L7B7, P43246 fragilis, Bacteroides thetaiotaomicron, Q8A334, A6KZM1, Bacteroides vulgatus, Porphyromonas Q7MXR7 gingivalis 228 DEPTNHLDME Escherichia coli, Escherichia coli, P0A9U3, P0A9U4, Q9NUQ8 Escherichia coli P0A9U5 229 DEVQTGFGR Bacillus pseudofirmus P30268 Q9BYV1 230 DEYVGLPRDH Corynebacterium kropnstedtii C4LL80 P46926 231 DFALWKAAKP Corynebacterium glutamicum, A4QH41, Q6NFC3, Q9HA77 Corynebacterium diphtheriae, Q8NMD7, C6B523 Corynebacterium glutamicum, Desulfovibrio salexigens 232 DFALWKASKP Fusobacterium nucleatum Q8RIK9 P49589 233 DFALWKASKPGE Desulfovibrio maeticus C4XSW5 P49589 P 234 DFIKTSTGK Aeromonas salmonicida, Aeromonas A4SRU4, A0KPE4, Q9Y315 hydrophila, Edwardsiella ictaluri, C5BHJ2, A4W698, Enterobacter sp., Escherichia coli, B1LEI6, B7LXU3, Escherichia coli, Escherichia B7LNS1, B6I6M8, fergusonii, Escherichia coli, B1IS38, A8A8B0, Escherichia coli, Escherichia coli, B7NW61, B7N2V7, Escherichia coli, Escherichia coli, B5Z4R3, Q8XB36, Escherichia coli, Escherichia coli, B7LEM7, A7ZVS4, Escherichia coli, Escherichia coli, B7UR09, P0A6L0, Escherichia coli, Escherichia coli, B7NH49, P0A6L1, Escherichia coli, Escherichia coli, B1XFJ1, B7MNI8, Escherichia coli, Escherichia coli, Q0T8T2, C4ZT63, Escherichia coli, Escherichia coli, A1AJU8, B8F671, Escherichia coli, Haemophilus Q7VMS9, B5Y277, parasuis, Haemophilus ducreyi, B4EWA4 Klebsiella pneumoniae, Proteus mirabilis 235 DFSGGWRMR Escherichia coli, Escherichia coli P63390, P63389 Q9UG63 236 DFSSPNIAK Fusobacterium nucleatum Q8RG14 P54136 237 DFTFVCPTE Bacillus sp., Escherichia coli, P26830, P0AE08, Q06830 Escherichia coli, Escherichia coli P0AE09, P0AE10 238 DFTFVCPTEI Bacillus subtilis Q34564 Q06830 239 DFTFVCPTEIIAF Helicobacter pylori, Helicobacter P56876, P21762 Q06830 pylori 240 DGAGKTSVL Streptococcus uberis B9DTV7 Q6T311 241 DGEAGGITQ Lactobacillus brevis Q03QT5 Q60841 242 DGGQWDMLV Listeria monocytogenes, Listeria Q69192, Q928V0 Q13867 innocua 243 DGHIAFNEP Corynebacterium diphtheriae Q6NJ91 P46926 244 DGHTASLFP Haemophilus influenzae, Helicobacter Q57039, O25730, Q95479 pylori, Helicobacter pylori, Q9ZKB1, Q9EV79, Pseudomonas putida, Pseudomonas Q9X2N2 aeruginosa 245 DGILVPGGFG Desulfovibrio desulfuricans B8IZF5 Q9NRF8 246 DGKLYGRGA Ralstonia solanacearum Q8XZK5 Q96KN2 247 DGLGFGDNTKAA Desulfitobacterium hafniense Q24VA4 P21695 248 DGPLDMRMD Acinetobacter baumannii, B0VPF9, B0V8N7, A6NJ78 Acinetobacter baumannii, A3M9K5, B2I0K7, Acinetobacter baumannii, B7GVN1, B7IAX1, Acinetobacter baumannii, Q6F7D1, A8ALL4, Acinetobacter baumannii, Q313R1, B8DP86, Acinetobacter baumannii, A1VBE0, P62470, Acinetobacter baylyi, Citrobacter C5B9E8, A4W6I5, koseri, Desulfovibrio alaskensis, B7LWH0, B1LG19, Desulfovibrio vulgaris, Desulfovibrio Q1RGB3, B6HZ59, vulgaris, Desulfovibrio vulgaris, A7ZW34, B7N7V5, Edwardsiella ictaluri, Enterobacter P60390, A1A7C7, sp., Escherichia fergusonii, B1IR96, Q0TLQ7, Escherichia coli, Escherichia coli, C5W331, B1XC59, Escherichia coli, Escherichia coli, C6UM45, C4ZQ04, Escherichia coli, Escherichia coli, B7M125, B5YZB8, Escherichia coli, Escherichia coli, P60391, B7LFV2, Escherichia coli, Escherichia coli, B7MAK5, A7ZHH3, Escherichia coli, Escherichia coli, B7NHI8, Q8FL68, Escherichia coli, Escherichia coli, B7MNU1, B7UID2, Escherichia coli, Escherichia coli, B3E3Z0, Q7VP62, Escherichia coli, Escherichia coli, B8F3A8, A6T4M5, Escherichia coli, Escherichia coli, B5Y1V5, B4F119, Escherichia coli, Escherichia coli, Q87WX7, C3KCS2, Escherichia coli, Geobacter lovleyi, Q4ZNY2, Q3K736, Haemophilus ducreyi, Haemophilus Q48EF0, Q4K6I5, parasuis, Klebsiella pneumoniae, A4VIH0, Q8XVH9, Klebsiella pneumoniae, Proteus C6BEJ1, B2UCY5 mirabilis, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas fluorescens, Pseudomonas stutzeri, Ralstonia solanacearum, Ralstonia pickettii, Ralstonia pickettii 249 DGPMPQTREH Lactobacillus brevis, Desulfovibrio Q03QN5, B8DLL9, P49411 vulgaris, Desulfovibrio vulgaris, A1VAK4, Q727D5, Desulfovibrio vulgaris, Desulfovibrio B8J1A0, Q30X13 desulfuricans, Desulfovibrio alaskensis 250 DGTKFDSSLDR Neisseria meningitidis P0A0W3 Q02790 251 DGVGTKLKIA Rhizobium leguminosarum Q9XAT2 P22102 252 DGWDSEPFT Campylobacter concisus A7ZFC1 Q96KP4 253 DHGKSTLADR Acinetobacter baumannii, B0VCT7, A3M7P5, Q8N442 Acinetobacter baumannii, B2HWQ2, B71580, Acinetobacter baumannii, B7GYS7, B0VTM2, Acinetobacter baumannii, Q6F9B9, A7GT14, Acinetobacter baumannii, Q9KD76, Q5WHG5, Acinetobacter baumannii, P37949, A8FFD6, Acinetobacter baylyi, Bacillus Q730L6, A7Z6W5, cytotoxicus, Bacillus halodurans, Q65H50, B7HCU5, Bacillus clausii, Bacillus subtilis, B7IYH2, C3L5S2, Bacillus pumilus, Bacillus cereus, B7HPL8, B7JNV1, Bacillus methylotrophicus, Bacillus Q81LR7, C3P8M5, licheniformis, Bacillus cereus, Bacillus Q6HDK2, Q634M2, cereus, Bacillus anthracis, Bacillus C1ESL3, A0RIT7, cereus, Bacillus cereus, Bacillus Q818E4, B9IY86, anthracis, Bacillus anthracis, Bacillus A9VHU6, Q38W39, thuringiensis, Bacillus cereus, Bacillus Q038N6, B3WEQ5, cereus, Bacillus thuringiensis, Bacillus C4Z9E3, C4Z541, cereus, Bacillus cereus, Bacillus Q6A9B2, A0RQX4, weihenstephanensis, Lactobacillus A1W018, Q9PNR1, sakei, Lactobacillus casei, A8FM79, Q5HU70, Lactobacillus casei, Eubacterium A7H311, B9KD01, rectale, Eubacterium eligens, A9KKU4, Q72E76, Propionibacterium acnes, B8DIZ5, C6BST2, Campylobacter fetus, Campylobacter Q30XI4, B8J444, jejuni, Campylobacter jejuni, Q831Z0, B2GHU9, Campylobacter jejuni, Campylobacter Q8Y742, B8DE32, jejuni, Campylobacter jejuni, C1KVC6, Q71ZJ1, Campylobacter lari, Clostridium Q92BN4, A0AIS8, phytofermentans, Desulfovibrio C5CCD4, Q5F9P9, vulgaris, Desulfovibrio vulgaris, B4RK41, A1KT27, Desulfovibrio salexigens, Q9K055, Q9JV65, Desulfovibrio alaskensis, A9M3J8, A4XSC1, Desulfovibrio desulfuricans, Q87XF8, Q1I5V6, Enterococcus faecalis, Kocuria C3K6G8, Q4KHT3, rhizophila, Listeria monocytogenes, A5W8F4, Q88MY7, Listeria monocytogenes, Listeria B0KV29, Q48EV0, monocytogenes, Listeria Q4ZPD8, B1J4D8, monocytogenes, Listeria innocua, Q3KHM1, A4VIX2, Listeria welshimeri, Micrococcus Q9I5G8, Q02HR9, luteus, Neisseria gonorrhoeae, B7UYX5, A6VAK9, Neisseria gonorrhoeae, Neisseria A8Z4C4, A6QHC7, meningitidis, Neisseria meningitidis, Q5HFH6, Q2FXY7, Neisseria meningitidis, Neisseria Q2FGD9, Q6G8Y3, meningitidis, Pseudomonas Q6GGB6, P65272, mendocina, Pseudomonas syringae, P65271, A5ITB2, Pseudomonas entomophila, Q2YT42, A7X2Y7, Pseudomonas fluorescens, A6U257, Q8NWA7, Pseudomonas fluorescens, Q4L6T4, Q5HNW2, Pseudomonas putida, Pseudomonas Q8CP13, B9DNK4, putida, Pseudomonas putida, Q49Y26, C1CKU6, Pseudomonas savastanoi, Q970K5, C1C7G9, Pseudomonas syringae, B5E4T8, B1ICO2, Pseudomonas putida, Pseudomonas A4VUL8, A4WOW0, fluorescens, Pseudomonas stutzeri, Q8DTF3, A8AWG3, Pseudomonas aeruginosa, C1CR98, Q8DPN5, Pseudomonas aeruginosa, B8Z069, Q04KB7, Pseudomonas aeruginosa, B9DSE0, Q5M008, Pseudomonas aeruginosa, Q03KW7, Q5M4M2, Staphylococcus aureus, B4U3G9, C0M8H9, Staphylococcus aureus, C1CEG3, P65274, Staphylococcus aureus, Q3K1F9, P65273, Staphylococcus aureus, C0MDV7, Q1JH37, Staphylococcus aureus, Q48TU0, Q1JLY8, Staphylococcus aureus, Q99ZV8, B5XLC6, Staphylococcus aureus, P0DC23, P0DC22, Staphylococcus aureus, Q1JC06, Q5XCD2, Staphylococcus aureus, Q1J6V6, Q82BZ3, Staphylococcus aureus, Q9RDC9, B1VY28 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus carnosus, Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus suis, Streptococcus suis, Streptococcus mutans, Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus uberis, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus equi, Streptococcus equi, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptomyces avermitilis, Streptomyces coelicolor, Streptomyces griseus 254 DHGKSTLADRL Desulfitobacterium hafniense, Q245R6, B8FUP2, Q8N442 Desulfitobacterium hafniense, A7I1F0, A7ZCJ3, Campylobacter hominis, A7GZW3, Q182F4, Campylobacter concisus, B0S1G2, Q7VJZ1, Campylobacter curvus, ptoclostridium A5VB59 difficile, Finegoldia magna, Helicobacter hepaticus, Sphingomonas wittichii 255 DHGKSTLADRLLE Bacteroides vulgatus, A6L744, A6LC18, Q8N442 Parabacteroides distasonis, Q8AA33, Q64T74, Bacteroides thetaiotaomicron, Q5LC85, Q97JJ6, Bacteroides fragilis, Bacteroides A0Q1R8, B8I3E6, fragilis, Clostridium acetobutylicum, A3DF29, Q892Q6, Clostridium novyi, Clostridium Q39U57, B5EB36, cellulolyticum, Clostridium A5G4G3, P60789, thermocellum, Clostridium tetani, C6DZ67, B9M4U5, Geobacter metallireducens, B3E9R0, B2RKK1, Geobacter bemidjiensis, Geobacter Q7MV56 uraniireducens, Geobacter sulfurreducens, Geobacter sp., Geobacter daltonii, Geobacter lovleyi, Porphyromonas gingivalis, Porphyromonas gingivalis 256 DHPDAFDNEL Clostridium botulinum, Clostridium A7GGE1, B1IJ68, Q9BZX2 botulinum, Clostridium botulinum, C1FSX6, C3L140, Clostridium botulinum, Clostridium B1KXA7 botulinurn 257 DHYENPRNVGS Escherichia coli, Escherichia coli, P0ACD5, P0ACD4, Q9H1K1 Escherichia coli P0ACD6 258 DHYENPRNVGSL Haemophilus influenzae Q57074 Q9H1K1 DK 259 DIEMSFVDQ Corynebacterium diphtheriae, Q6NGZ4, Q49Y68, Q6PI48 Staphylococcus saprophyticus, Q2FXU5, P67016, Staphylococcus aureus, A8Z2F7, Q6G8T9, Staphylococcus aureus, P67015, A6QHH2, Staphylococcus aureus, P67014, Q5HFD3, Staphylococcus aureus, A5ITF4, Q2YT75, Staphylococcus aureus, Q2FG97, A7X344, Staphylococcus aureus, A6U298, Q6GG73, Staphylococcus aureus, Q4L6X5, Q8C599, Staphylococcus aureus, Q5HN52 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 260 DILVNNAGI Bacillus subtilis, Bacillus subtilis, P42317, P50842, Q6IAN0 Haemophilus influenzae P43713 261 DILVNNAGV Rhizobium meliloti O86034 P15428 262 DISPQAPTH Escherichia coli, Escherichia coli P0ACE7, P0ACE8 P49773 263 DIYSRLLRERI Methylobacterium populi, B1Z9C7, A9W5F5, Q16740 Methylobacterium extorquens, B7KNT0, B1LW28, Methylobacterium extorquens, B8IN26, Q1MK43, Methylobacterium radiotolerans, P58277, Q2KAB9 Methylobacterium nodulans, Rhizobium leguminosarum, Rhizobium meliloti, Rhizobium etli 264 DKAGGYGIQ Parabacteroides distasonis, A6L8E5, Q3KI22 O95671 Pseudomonas fluorescens 265 DKHSTGGVGD Rhizobium loti Q98GV5 P19971 266 DKPDTRFGM Eubacterium rectale C4ZI12 Q6PI48 267 DKPRYLMGVG Acinetobacter baumannii, Aeromonas B0VRA8, A0KJ20, Q9BXR0 hydrophila, Aeromonas salmonicida, A45P26, Q38YP9, Lactobacillus sakei, Bacillus clausii, Q5WHR2, A8AK48, Citrobacter koseri, Desulfovibrio A1VFP3, Q72E53, vulgaris, Desulfovibrio vulgaris, C5BCF7, A4W779, Edwardsiella ictaluri, Enterobacter B7LMI1, B7N8V8, sp., Escherichia fergusonii, B1J043, Q1RFD5, Escherichia coli, Escherichia coli, B1LJF4, B6HZK6, Escherichia coli, Escherichia coli, B7M3P5, P0A847, Escherichia coli, Escherichia coli, P0A848, B7L639, Escherichia coli, Escherichia coli, Q0TKN5, A7ZX57, Escherichia coli, Escherichia coli, A1A876, C4ZTG3, Escherichia coli, Escherichia coli, B7MD64, B1XEZ4, Escherichia coli, Escherichia coli, B5Z2W2, B7MPG7, Escherichia coli, Escherichia coli, B7NJ96, P0A849, Escherichia coli, Escherichia coli, A7ZIF8, B7UJM9, Escherichia coli, Escherichia coli, Q4QNU3, A5UG47, Escherichia coli, Haemophilus A5UAP3, P44594, influenzae, Haemophilus influenzae, Q0I4R8, B8F3W0, Haemophilus influenzae, Q7VLQ4, A6T5D8, Haemophilus influenzae, B5Y0Y6, B4EU13, Haemophilus somnus, Haemophilus Q88PL7, Q9HXH9, parasuis, Haemophilus ducreyi, B7UVU4, Q02RX7, Klebsiella pneumoniae, Klebsiella Q887B0, Q92PY4, pneumoniae, Proteus mirabilis, Q98M57, Q4L6Y4 Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Rhizobium meliloti, Rhizobium loti, Staphylococcus haemolyticus 268 DKTGTITHG Ralstonia solanacearum Q8XU11 P35670 269 DLAIDGADEVD Staphylococcus haemolyticus Q4L8J6 P49247 270 DLEFVQFHPT Rhizobium loti, Streptomyces Q98AV8, Q9X8N8 P31040 coelicolor 271 DLIIPRGSS Bacteroides fragilis, Bacteroides Q64Z29, Q5LI24, P54886 fragilis, Bacteroides thetaiotaomicron, Q8A1E8, A6LE74 Parabacteroides distasonis 272 DLIVSNPPY Aeromonas hydrophila, Aeromonas A0KPC4, A4SRS5, Q9Y5R4 salmonicida, Fusobacterium Q8R619, A5HY34, nucleatum, Clostridium botulinum, A4WDE6, Q74862, Enterobacter sp., Geobacter P45253, B8F678, sulfurreducens, Haemophilus B4F055 influenzae, Haemophilus parasuis, Proteus mirabilis 273 DLIVSNPPYV Neisseria meningitidis, Neisseria Q9JTA1, Q9JYC0, Q9Y5R4 meningitidis, Neisseria gonorrhoeae, Q5F783, Q91347 Pseudomonas aeruginosa 274 DLKKAYRRLA Pseudomonas fluorescens, C3K274, Q1IF58 Q9NXW2 Pseudomonas entomophila 275 DLNRAGVGL Uncultured termite B1GZD2 O75879 276 DLPLNVSRE Arcobacter butzleri, Methylobacterium A8EV23, B0UN89, P14625 sp., Geobacter uraniireducens, A5GER7, Q17VU7, Helicobacter acinonychis, Q1CUU4, Q9ZMM2, Helicobacter pylori, Helicobacter Q7VFD7, B81U50, pylori, Helicobacter hepaticus, B1LZG0, Q2JZH2, Methylobacterium nodulans, P58477 Methylobacterium radiotolerans, Rhizobium etli, Rhizobium meliloti 277 DLQEDKEAVF Bifidobacterium longum, B7GTN9, Q8G5F3, P04424 Bifidobacterium longum, B3DSY6 Bifidobacterium longum 278 DLRLNEPRYA Pseudomonas aeruginosa Q9HZP6 P38117 279 DLTDEEKQE Bacillus licheniformis Q65KJ6 Q969G3 280 DLTHNPEFT Campylobacter hominis A7I358 Q15046 281 DLTHNPEFTT Campylobacter jejuni, Campylobacter A8FKI8, A7H4X7, Q15046 jejuni, Campylobacter jejuni, Q5HW66, A1VYC1, Campylobacter jejuni, Campylobacter P41258 jejuni 282 DLTVPFARY Propionibacterium acnes, Q6A8J7, C5CCH4 P12081 Micrococcus luteus 283 DLVGNNTPIFF Micrococcus luteus P29422 P04040 284 DLVGNNTPIFFI Escherichia coli P21179 P04040 285 DNFWEMGDTGPC Bacteroides fragilis, Bacteroides Q64Y64, Q5LHE6, P49588 GPCSEIH fragilis, Bacteroides thetaiotaomicron, Q8A0M6, A6LEZ8, Parabacteroides distasonis, A6L1L8, Q7MV54 Bacteroides vulgatus, Porphyromonas gingivalis 286 DNHLILVDL Clostridium perfringens, Clostridium Q8XJ32, Q0TP32, P34896 perfringens, Clostridium botulinum, B2V398, Q0SRQ2, Clostridium perfringens, Clostridium B2TN52 botulinurn 287 DNHLILVDLRS Bacillus subtilis P39148 P34896 288 DPLDGSSNI Methylobacterium radiotolerans, B1LUU9, B1Z939, P09467 Methylobacterium populi, B7L270, A9W1C8 Methylobacterium extorquens, Methylobacterium extorquens 289 DPLDGSSNID Aeromonas hydrophila, Aeromonas A0KJT2, A4SM33, P09467 salmonicida, Citrobacter koseri, A8AMG4, A4W5X6, Enterobacter sp., Escherichia coli, Q1R324, B1LRB5, Escherichia coli, Escherichia coli, P0A994, P0A993, Escherichia coli, Escherichia coli, B1ISX3, Q0T9F7, Escherichia coli, Escherichia coli, A1AJD7, A8A7Y7, Escherichia coli, Escherichia coli, B1XEL4, A7ZVB0, Escherichia coli, Escherichia coli, B5Z317, Q8XCF0, Escherichia coli, Haemophilus A5UCP1, P45292, influenzae, Haemophilus influenzae, Q7VN74, Q4QL80, Haemophilus ducreyi, Haemophilus Q0I4Y5, B5Y2X3, influenzae, Haemophilus somnus, A6THE3, B4F298, Klebsiella pneumoniae, Klebsiella Q9EXV4 pneumoniae, Proteus mirabilis, Rhizobium meliloti 290 DPSIFTVLT Pseudomonas syringae Q4ZR64 Q93099 291 DPTLLFANAGMN Geobacter metallireducens, Q39Z77, P61701 P49588 QFK Geobacter sulfurreducens 292 DQISDAVLD Desulfovibrio alaskensis, Q311V1, Q7VNG7, P31153 Haemophilus ducreyi, Haemophilus A5UIU0, A5UCT6, influenzae, Haemophilus influenzae, P43762, Q4QLC5, Haemophilus influenzae, Q0I559, B8F4B2, Haemophilus influenzae, Q7VFY5, Q9ZMN5, Haemophilus somnus, Haemophilus B6JPU7, B5Z9W8, parasuis, Helicobacter hepaticus, Q1CUW4, B2US27, Helicobacter pylori, Helicobacter P56460, Q17YQ7 pylori, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori, Helicobacter acinonychis 293 DQISDAVLDA Citrobacter koseri, Edwardsiella A8APG1, C5BAV4, Q00266 ictaluri, Enterobacter sp., Escherichia A4WE78, B7LPQ9, fergusonii, Escherichia coli, B1LDF1, B61780, Escherichia coli, Escherichia coli, B7N7J5, P0A817, Escherichia coli, Escherichia coli, B1IT65, P0A818, Escherichia coli, Escherichia coli, A8A481, Q0TDR0, Escherichia coli, Escherichia coli, B1XFA4, C5A0L1, Escherichia coli, Escherichia coli, B5YQD9, B7NI05, Escherichia coli, Escherichia coli, B7LYX2, P0A819, Escherichia coli, Escherichia coli, B7LFK4, B7UHY9, Escherichia coli, Escherichia coli, A7ZR64, A6TDV1, Klebsiella pneumoniae, Klebsiella B5XUA8, B4F1A5, pneumoniae, Proteus mirabilis, A4XPF8, Q48CH3, Pseudomonas mendocina, Q4ZMO1, Q88AK7, Pseudomonas savastanoi, A4VRE8, C3K3F5, Pseudomonas syringae, B1J2Z8, Q4K4I7, Pseudomonas syringae, Q3K5E8, A6UZ09, Pseudomonas stutzeri, Pseudomonas Q915Z0, Q02TL9, fluorescens, Pseudomonas putida, B7V4D3, Q88D60, Pseudomonas fluorescens, B0KLZ1, A5WA00, Pseudomonas fluorescens, Q1I3X6, B2FPC7, Pseudomonas aeruginosa, B4SK03 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 294 DRILASRMG Clostridium tetani Q890Z2 Q01813 295 DRQPEFTQID Lactobacillus casei, Lactobacillus Q038S1, B3WEM2, Q6PI48 casei, Lactobacillus plantarum, Q88V08, Q38X136, Lactobacillus sakei, Lactobacillus Q74IX4, Q5FKI4, johnsonii, Lactobacillus acidophilus, B2G6X9, A5VJG4, Lactobacillus reuteri, Lactobacillus B2GBY7, Q64T01, reuteri, Lactobacillus fermentum, Q5LCK2, A6LBU6, Bacteroides fragilis, Bacteroides Q9PHM7, A8FL61, fragilis, Parabacteroides distasonis, A1VZ00, A8AFH5, Campylobacter jejuni, Campylobacter A9KIA6, A4WBM3, jejuni, Campylobacter jejuni, Q8XCI7, B5YR11, Citrobacter koseri, Clostridium P21889, A8A166, phytofermentans, Enterobacter sp., C4ZQF0, B1XHD4, Escherichia coli, Escherichia coli, B7NS52, B6IBU5, Escherichia coli, Escherichia coli, B1LD05, B7NBL7, Escherichia coli, Escherichia coli, B1J0M2, B7M2F7, Escherichia coli, Escherichia coli, B7L7R9, A7ZMZ0, Escherichia coli, Escherichia coli, B7LPH8, B7USP3, Escherichia coli, Escherichia coli, Q1RAR8, Q8FGQ9, Escherichia coli, Escherichia coli, Q0TGW6, A1AC27, Escherichia fergusonii, Escherichia B7MVZ7, B7MBS5, coli, Escherichia coli, Escherichia coli, C6E3W7, B5EIV1, Escherichia coli, Escherichia coli, A5G3L5, Q74D56, Escherichia coli, Escherichia coli, B9M1C9, Q39VY3, Geobacter sp., Geobacter Q7VNF0, B8F789, bemidjiensis, Geobacter A5UAG7, A5UGD3, uraniireducens, Geobacter A6TB35, B5XQ00, sulfurreducens, Geobacter daltonii, B8DHM9, Q71ZF1, Geobacter metallireducens, C1KVG6, Q8Y709, Haemophilus ducreyi, Haemophilus Q92BJ4, A0AIW8, parasuis, Haemophilus influenzae, A9M257, B4RPA1, Haemophilus influenzae, Klebsiella A1KVG2, Q9JT23, pneumoniae, Klebsiella pneumoniae, Q9K0U5, Q03F52, Listeria monocytogenes, Listeria B4ETP3 monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria innocua, Listeria welshimeri, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis, Neisseria meningitidis, Pediococcus ntosaceus, Proteus mirabilis 296 DRQPEFTQIDIE Bacillus clausii, Bacillus halodurans, Q5WHP3, Q9KDG1, Q6PI48 Enterococcus faecalis, Pseudomonas Q833I2, Q3K7V6, fluorescens, Pseudomonas syringae, Q4ZWL5, Q87Y31, Pseudomonas syringae, Q48FC1, C3JYT1 Pseudomonas savastanoi, Pseudomonas fluorescens 297 DRQPEFTQIDIEM Bacillus subtilis, Bacillus O32038, A7Z750, Q6PI48 SF methylotrophicus, Bacillus Q65GR4, Q5HVD1, licheniformis, Campylobacter jejuni, Q7VF76 Helicobacter hepaticus 298 DRQPEFTQIDIEM Clostridium cellulolyticum B8I3F1 Q6PI48 SFV 299 DRTGTGTLS Citrobacter koseri, Corynebacterium A8AP42, C3PEY5, P04818 aurimucosum, Edwardsiella ictaluri, C5BH86, A4WE03, Enterobacter sp., Escherichia coli, A8A3W0, B1IU17, Escherichia coli, Escherichia coli, P0A884, B7N759, Escherichia coli, Escherichia coli, P0A885, B7LY83, Escherichia coli, Escherichia coli, B7NVX2, C4ZZX9, Escherichia coli, Escherichia coli, B7MZC6, Q1R7I6, Escherichia coli, Escherichia coli, P0A886, Q0TE05, Escherichia coli, Escherichia coli, B7LF04, A1AF39, Escherichia coli, Escherichia coli, B7UHP4, B7MLH3, Escherichia coli, Escherichia coli, A7ZQT3, B7LNI2 Escherichia fergusonii 300 DRTGTGTLSVFG Methylobacterium extorquens, B7KQG2, B8IF20, P04818 Methylobacterium nodulans, Neisseria O33380 gonorrhoeae 301 DSGGARIQEG Propionibacterium freudenreichii Q8GBW6 P05166 302 DSKPGTIRGD Clostridium thermocellum A3DDC2 O60361 303 DSRGNPTVE Aeromonas salmonicida, Aeromonas A4SRC1, A0KGH3, P06733 hydrophila, Aeromonas hydrophila, Q8GE63, Q74K78, Lactobacillus johnsonii, Lactobacillus Q042F4, C3PFA7, gasseri, Corynebacterium Q6NI61, Q8NRS1, aurimucosum, Corynebacterium A4QCV0, Q8FQS7, diphtheriae, Corynebacterium C5B8X2, A4WDW7, glutamicum, Corynebacterium B7LWP5, Q1R7R4, glutamicum, Corynebacterium B1LQB2, B6I6H5, efficiens, Edwardsiella ictaluri, B7N715, P0A6P9, Enterobacter sp., Escherichia B7MZ75, B1IU62, fergusonii, Escherichia coli, P0A600, Q0TE80, Escherichia coli, Escherichia coli, A7ZQM2, A1AEW7, Escherichia coli, Escherichia coli, A8A3R4, B1XDI9, Escherichia coli, Escherichia coli, C4ZZT2, B7LXJ5, Escherichia coli, Escherichia coli, B7NV69, B5Z3E3, Escherichia coli, Escherichia coli, P0A6Q1, B7LEJ8, Escherichia coli, Escherichia coli, B7MLA0, B7UHJ5, Escherichia coli, Escherichia coli, Q011Z1, B8F8L5, Escherichia coli, Escherichia coli, Q7VNM6, A5UDD6, Escherichia coli, Escherichia coli, P43806, Q4QLX6, Escherichia coli, Escherichia coli, A5UI73, B5XV19, Haemophilus somnus, Haemophilus A6TD53, A9LZL4, parasuis, Haemophilus ducreyi, B4RMD8, Q5F8Z2, Haemophilus influenzae, Q9JU46, Q9JZ53, Haemophilus influenzae, A1KUB6, B4EUF7, Haemophilus influenzae, A6V1F3, Q9HXZ5, Haemophilus influenzae, Klebsiella B7V7V4, Q02RA7, pneumoniae, Klebsiella pneumoniae, A4XWS1, Q48F79, Neisseria meningitidis, Neisseria Q4ZWQ8, Q886M3, gonorrhoeae, Neisseria gonorrhoeae, Q3KH92, Q4KHF6, Neisseria meningitidis, Neisseria B1JB38, Q88MF9, meningitidis, Neisseria meningitidis, B0KSB9, Q1I646, Proteus mirabilis, Pseudomonas B2U9C3, Q8Y0B5 aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Ralstonia pickettii, Ralstonia solanacearum 304 DSRGNPTVEV Bacillus cytotoxicus, Bacillus A7GUR7, Q6HBF3, P06733 thuringiensis, Bacillus anthracis, C3P0A3, C1EZA0, Bacillus cereus, Bacillus thuringiensis, A0RKS3, Q81X78, Bacillus anthracis, Bacillus cereus, B7JFG3, C3LDI0, Bacillus anthracis, Bacillus cereus, Q631M2, A9VQ48, Bacillus weihenstephanensis, Q03AK4, Q65EN2, Lactobacillus casei, Bacillus B3WCVV7, Q88YH3, licheniformis, Lactobacillus casei, A7Z8Y1, P37869, Lactobacillus plantarum, Bacillus A8FHJ0, B7HW52, methylotrophicus, Bacillus subtilis, B9J4M4, Q72XY5, Bacillus pumilus, Bacillus cereus, B7HED2, Q815K8, Bacillus cereus, Bacillus cereus, B7IP20, Q03SL5, Bacillus cereus, Bacillus cereus, Q5WDK9, Q9K717, Bacillus cereus, Lactobacillus brevis, Q24MW5, B7GTK2, Bacillus clausii, Bacillus halodurans, A1A143, A0PYP4, Desulfitobacterium hafniense, Q181T5, A3DBQ5, Bifidobacterium longum, B8I4U1, C4LHL7, Bifidobacterium adolescentis, B1VFL0, B8J467, Clostridium novyi, ptoclostridium C6BSL8, Q316Q0, difficile, Clostridium thermocellum, C4XLR9, O32513, Clostridium cellulolyticum, B0S1G7, B2GM13, Corynebacterium kropnstedtii, A0ALD9, P64074, Corynebacterium urealyticum, P64075, Q71WX1, Desulfovibrio desulfuricans, B8DDA1, C1KY94, Desulfovibrio salexigens, C5C987, Q03GW5, Desulfovibrio alaskensis, Q6AAB8, Q8CPY3, Desulfovibrio maeticus, Desulfovibrio Q5HQV0, Q4L4K7, vulgaris, Finegoldia magna, Kocuria B9DJJ9, O69174, rhizophila, Listeria welshimeri, Listeria Q6GIL4, A8Z1A4, monocytogenes, Listeria innocua, A6QF85, P64079, Listeria monocytogenes, Listeria P64078, Q6GB54, monocytogenes, Listeria Q2YSE8, P99088, monocytogenes, Micrococcus luteus, Q5HHP1, Q2G028, Pediococcus ntosaceus, A5I0Y0, A7WZT2, Propionibacterium acnes, Q2FIL7, A6TZQ5, Staphylococcus epidermidis, Q49W03, Q9F2Q3, Staphylococcus epidermidis, Q82HH5 Staphylococcus haemolyticus, Staphylococcus carnosus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Streptomyces coelicolor, Streptomyces avermitilis 305 DSRGNPTVEVD Fusobacterium nucleatum, Q8RI55, A6L3M9, P06733 Bacteroides vulgatus, Bacteroides Q8KNX9, Q5LG64, fragilis, Bacteroides fragilis, Q89Z05, Q4JU51, Bacteroides thetaiotaomicron, B7KRB4, A9W6G9, Corynebacterium jeikeium, B1ZEJ8, B1LZU6, Methylobacterium extorquens, A5V3E8, B1GYL7 Methylobacterium extorquens, Methylobacterium populi, Methylobacterium radiotolerans, Sphingomonas wittichii, Uncultured termite 306 DTCQGDSGGP Streptomyces exfoliatus, P80420, P00775 P10323 Streptomyces griseus 307 DTGMGLERL Clostridium phytofermentans, A9KMW7, B1GZ43 Q5JTZ9 Uncultured termite 308 DTRGIFRVH Propionibacterium acnes Q6A5P0 P49591 309 DTRGIFRVHQF Streptomyces avermitilis, Q82FK8, Q9ZBX1, P49591 Streptomyces coelicolor, B1VP80 Streptomyces griseus 310 DVANAVLDG Lactobacillus delbrueckii, Escherichia P34038, P21599 P30613 coli 311 DVAVIGVPD Proteus mirabilis, Proteus sp. B4EY25, Q8GB18 Q4G176 312 DVFCEKGVF Parabacteroides distasonis A6LI30 Q96NU7 313 DVGCGSGIL Clostridium beijerinckii A6LRN8 Q86X55 314 DVGCGTGILS Clostridium thermocellum A3DF23 O60678 315 DVINAAEKL Escherichia coli, Escherichia coli, P0A9T2, P0A9T0, Q43175 Escherichia coli P0A9T1 316 DVKVVILGQDPYH Lactobacillus casei, Lactobacillus B3WCZ5, Q03AI1 P13051 casei 317 DVKVVILGQDPYH Campylobacter concisus, A7ZAZ4, Q4QPM6, P13051 G Haemophilus influenzae, A5UBC0 Haemophilus influenzae 318 DVKVVILGQDPYH Bacillus subtilis, Escherichia P39615, B7LUY5, P13051 GP fergusonii, Escherichia coli, B7MYL3, Q1R8F2, Escherichia coli, Escherichia coli, B1LP93, A1AEB0, Escherichia coli, Escherichia coli, B7MIR5, B7UH19, Escherichia coli, Escherichia coli, A7ZQ25, Q0TEQ8, Escherichia coli, Escherichia coli, B7NRN6, B7N6H1, Escherichia coli, Escherichia coli, Q8X444, B5Z154, Escherichia coli, Escherichia coli, B615F5, P12295, Escherichia coli, Escherichia coli, B1IVP7, B1XBQ7, Escherichia coli, Escherichia coli, A8A392, C4ZYK3, Escherichia coli, Escherichia coli, B7M8J5, B7LDH3, Escherichia coli, Escherichia coli, Q8FF08, A6TCJ2, Klebsiella pneumoniae, Klebsiella B5XNF8, A3CN85, pneumoniae, Streptococcus A8AXM4 sanguinis, Streptococcus gordonii 319 DVKVVILGQDPYH Desulfitobacterium hafniense, Q24YA3, B8FSV8, P13051 GPNQAHGL Desulfitobacterium hafniense, B2TQZ9, B2V017, Clostridium botulinum, Clostridium P43731, Q4L3Q7 botulinum, Haemophilus influenzae, Staphylococcus haemolyticus 320 DVLDTWFSS Desulfovibrio vulgaris, Geobacter Q72E47, Q74BJ6 P26640 sulfurreducens 321 DVLDTWFSSGL Helicobacter pylori, Helicobacter P56000, Q9ZK61 P26640 pylori 322 DVLVATDVAS Helicobacter pylori, Helicobacter O25029, B9XXL6 Q9UJV9 pylori 323 DVLVNNAGI Acinetobacter sp., Escherichia coli, P50203, P0A9Q0, P16152 Escherichia coli, Staphylococcus P0A9P9, Q8CPI3, epidermidis, Staphylococcus Q5HPW0 epidermidis 324 DVLVNNAGIA Corynebacterium glutamicum Q9ZNN8 P16152 325 DVMDGHFVPNIT Bacillus subtilis O34557 Q20D12 326 DVSELTGFPE Rhizobium sp., Rhizobium meliloti C3MAR5, Q92KX6 P31939 327 DWIVGAGPAGLS Acinetobacter baylyi, Pseudomonas P94132, Q9HZP5 Q16134 AA aeruginosa 328 DVWEHAYYL Acinetobacter baylyi, Bacillus Q59094, Q81LW0, P04179 anthracis, Bacillus halodurans, Q9KD10, Q81811, Bacillus cereus, Enterococcus Q838I4, P66828, faecalis, Escherichia coli, Escherichia P00448, P43725, coli, Haemophilus influenzae, O30826, Q92BR6, Haemophilus ducreyi, Listeria P28764, P28763 innocua, Listeria ivanovii, Listeria P77929, P19665 monocytogenes, Porphyromonas P53652, P0C0Q6, gingivalis, Pseudomonas putida, Q5HNZ5, Q8VQ15, Pseudomonas aeruginosa, Q9F326, Q49XZ6, Staphylococcus epidermidis, Q9K4V3, Q4L6Q3, Staphylococcus epidermidis, P0A0J2, Q6G913, Staphylococcus epidermidis, P99098, Q6GGE6, Staphylococcus carnosus, Q5HFK7, P0A0J1, Staphylococcus saprophyticus, P0A0J3, Q2YT26, Staphylococcus xylosus, Q2FGH0, Q2YUU9, Staphylococcus haemolyticus, P66831, P66832, Staphylococcus aureus, Q6GCZ1, Q6GKH2, Staphylococcus aureus, P66830, Q5HJN5, Staphylococcus aureus, Q2G261, Q2FKC6, Staphylococcus aureus, P0DF73, P0DF72, Staphylococcus aureus, Q8P0D4, Q5XBF8, Staphylococcus aureus, P0C011, P0C010, Staphylococcus aureus, P09738, P0A4J5, Staphylococcus aureus, P0A4J4, P0A4J3 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae 329 DVWEHAYYLQYK Bacillus subtilis O35023 P04179 N 330 DVYVNDAFGTAH Ralstonia solanacearum Q8Y1W6 P07205 RA 331 DVYVNDAFGTAH Clostridium acetobutylicum O52632 P07205 RAH 332 DWRTKKPVV Lactobacillus delbrueckii, Q041365, Q1GAS8 Q9N5E4 Lactobacillus delbrueckii 333 DYGPFGFLD Escherichia coli, Escherichia coli, B7L6H9, B6I8R1, Q9BVL4 Escherichia coli, Escherichia coli, Q0THC2, B1I050, Escherichia coli, Escherichia coli, B7N544, Q1RB89, Escherichia coli, Escherichia coli, Q8FH30, B7MAR7, Escherichia coli, Escherichia coli, A1ABP2, B7US45, Escherichia coli, Escherichia coli, B7MVI5, B7NTS5, Escherichia coli, Escherichia coli, P77649, C4ZYG8, Escherichia coli, Escherichia coli, B1XG13, A7ZMH3, Escherichia coli, Escherichia coli, A8A0P8, B1LE24, Escherichia fergusonii B7LQ82 334 DYYEILGVS Escherichia fergusonii, Escherichia B7LVP7, B1LFU5, Q9NXW2 coli, Escherichia coli, Escherichia coli, Q1RGI7, B6HZ11, Escherichia coli, Escherichia coli, B7N7N9, B1IRF9, Escherichia coli, Escherichia coli, Q8FLC5, A7ZVV8, Escherichia coli, Escherichia coli, B7M0B1, B7NHB7, Escherichia coli, Escherichia coli, B7MNM2, Q8XA65, Escherichia coli, Escherichia coli, B7L4D9, B7MAD6, Escherichia coli, Escherichia coli, B7UI60, A7ZHA5, Escherichia coli, Escherichia coli, P08622, B1XBE0, Escherichia coli, Escherichia coli, C4ZPU1, B5YYA8, Klebsiella pneumoniae, Klebsiella A6T4F5, B5Y241 pneumoniae 335 DYYEVLGLQ Clostridium botulinum, Clostridium B2TLZ8, B2V216, Q7Z6W7 botulinum, Clostridium perfringens, Q8XIT1, Q4QJW5, Haemophilus influenzae, B8F7S3, P48208, Haemophilus parasuis, Haemophilus P43735 ducreyi, Haemophilus influenzae 336 EAAPGTIRGD Bacillus clausii Q5WGT0 O00746 337 EAAPGTIRGDF Bacillus cereus, Bacillus cereus, Q81FQ4, Q73AY0, O00746 Bacillus thuringiensis, Bacillus Q6HL40, Q81SV8, anthracis, Bacillus cereus Q63DL7 338 EAGDGTTTATVLA Arcobacter butzleri, Pseudomonas A8ERY3, A4VP82, P10809 stutzeri, Pseudomonas stutzeri O33500 339 EAIKRDFGSF Bacteroides fragilis P53638 P04179 340 EALREVSAAR Streptococcus pyogenes, B5XJH4, Q8P2U5, P15313 Streptococcus pyogenes, P0DA08, Q9AIQ2, Streptococcus pyogenes, Q1JDW9, P0DA09, Streptococcus pyogenes, Q1JNS7, A2RC98, Streptococcus pyogenes, Q1J8S4, Q5XE49, Streptococcus pyogenes, Q1JIX4, Q48VL2, Streptococcus pyogenes, A8AUJ8, A3CK49, Streptococcus pyogenes, B1ICC8, B8ZK30, Streptococcus pyogenes, C1CES1, Q97QA9, Streptococcus pyogenes, B5E551, B2IP44 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus gordonii, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 341 EASGTGNMKFML Streptococcus pneumoniae P29849 P06737 NGALT 342 EAYEVLSDA Pseudomonas aeruginosa, Q9HV44, Q02FR2, O75190 Pseudomonas aeruginosa, B7V1H2, A6VCL7, Pseudomonas aeruginosa, B0K1S4, B1J255, Pseudomonas aeruginosa, A4XYF5, Q88DU3, Pseudomonas putida, Pseudomonas A5W9A2, Q87WP1, putida, Pseudomonas mendocina, Q4ZNP8, Q48E63 Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi 343 EAYEVLSDE Bacillus cytotoxicus, Staphylococcus A7GT07, Q49Y21, Q96EY1 saprophyticus, Staphylococcus Q5HNW7, Q8CP18, epidermidis, Staphylococcus B9DNJ9 epidermidis, Staphylococcus carnosus 344 EAYEVLSDP Pseudomonas stutzeri Q6VAY5 Q9UDY4 345 EAYEVLSDS Pseudomonas fluorescens Q4KIH0 Q8NHS0 346 ECKIGIMPG Staphylococcus aureus, P99070, P66866, P53597 Staphylococcus aureus, Q5HGI6, Q8NX01, Staphylococcus aureus, Q6G9W7, Q6GHI9, Staphylococcus aureus, Q5HPU4, Q8CPH4 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 347 EDPVTGSAH Pseudomonas aeruginosa, Q9I073, Q9HY42 P30039 Pseudomonas aeruginosa 348 EDQIYRIDHYLGK Bacillus subtilis P54547 P11413 349 EDRIVKRFL Sphingomonas wittichii A5VDD4 A6NJ78 350 EDVKKRI LE Finegoldia magna B052N4 P36776 351 EEARGDQCD Bacillus thuringiensis, Bacillus cereus, Q6HBM0, B7JEJ3, P56192 Bacillus cereus, Bacillus thuringiensis, C1EYD5, A0RKM3, Bacillus anthracis, Bacillus anthracis, C3LD96, C3P025, Bacillus anthracis Q81XF9 352 EEGDLGPVYG Pseudomonas putida A5WAK1 P04818 353 EEHDQEGRVI Bacillus subtilis P37454 P27695 354 EEIFGPVLVV Escherichia coli P23883 O02252 355 EEIKKAYRK Bacteroides thetaiotaomicron, Q8A8C3, Q5LED4, Q8WW22 Bacteroides fragilis, Bacteroides Q64VI7 fragilis 356 EEMRQSLRI Streptomyces avermitilis, Q82DX8, Q9XAQ7 O75306 Streptomyces coelicolor 357 EEMRQSLRII Akkermansia muciniphila, B2ULZ0, B1W516 O75306 Streptomyces griseus 358 EFTQIDIEMSFVD Desulfovibrio vulgaris Q72507 Q6PI48 359 EFYMAYADY Aeromonas hydrophila, Aeromonas A0KNK7, A4SJK0 Q15046 salmonicida 360 EGDSAFGFSGME Escherichia coli, Escherichia coli P0AFI0, P0AFII Q9UJ83 361 EGGGCSGFQY Stenotrophomonas maltophilia, B2FJT4, B4SLD1 Q86U28 Stenotrophomonas maltophilia 362 EGGVHRVQRVP Akkermansia muciniphila B2UL99 Q9UGC7 363 EGHPDKICD Corynebacterium aurimucosum C3PG24 Q00266 364 EGHPDKICDQISD Bacillus licheniformis, Bacillus Q65FV8, Q9K7Q9, Q00266 halodurans, Bacillus A7Z7Y9, P54419, methylotrophicus, Bacillus subtilis, A8FGH7, A7GU40, Bacillus pumilus, Bacillus cytotoxicus, C1EW36, A0RJZ7, Bacillus cereus, Bacillus thuringiensis, B9J265, Q632S5, Bacillus cereus, Bacillus cereus, C3PCC4, B7JT32, Bacillus anthracis, Bacillus cereus, Q81KI0, C3LAZ9, Bacillus anthracis, Bacillus anthracis, Q6HCB4, B7HSV6, Bacillus thuringiensis, Bacillus cereus, B7H9C7, Q8I6Q8, Bacillus cereus, Bacillus cereus, Q72YV6, B7IL28, Bacillus cereus, Bacillus cereus, A9VLC6, QI8CL7 Bacillus weihenstephanensis, ptoclostridium difficile 365 EGHPDKICDQISD Bacillus clausii, Desulfitobacterium Q5WDZ8, B8FSB9, Q00266 A hafniense, Bifidobacterium animalis, B8DTW8, Q97F85 Clostridium acetobutylicum 366 EGHPDKICDQISD Clostridium perfringens, Clostridium Q0SR05, Q0TND4, Q00266 AVLDA perfringens, Clostridium botulinum, C1FQQ5, Q898W7, Clostridium tetani, Clostridium B1IE45, A5HY62, botulinum, Clostridium botulinum, A7F0I8, A7G9S1, Clostridium botulinum, Clostridium B1KST9, A9KL72, botulinum, Clostridium botulinum, A3DHM4, B8I4C1 Clostridium phytofermentans, Clostridium thermocellum, Clostridium cellulolyticum 367 EGWLAEHMLIL Streptomyces avermitilis Q82171 P35558 368 EGYNTWGE Aggregatibacter P23702 Q9NUT2 actinomycetemcomitans 369 EGYPGKRYYGG Acinetobacter radioresistens, O85718, Q6FA66, P34897 Acinetobacter baylyi, Acinetobacter A3M736, B0VBB3, baumannii, Acinetobacter baumannii, B2HUY9, B7GZR6, Acinetobacter baumannii, B712R7, B0VLF5, Acinetobacter baumannii, Q046F8, Q74LC1, Acinetobacter baumannii, Q03QY0, A7Z9Q9, Acinetobacter baumannii, B2GAT4, Q65DW5, Lactobacillus gasseri, Lactobacillus A8FIC1, Q8IJY4, johnsonii, Lactobacillus brevis, C3P1G5, C3LFJ0, Bacillus methylotrophicus, B7JGP1, C1F0N9, Lactobacillus fermentum, Bacillus Q24MM6, B8FZ69, licheniformis, Bacillus pumilus, Q8A9S7, A6L5K3, Bacillus anthracis, Bacillus anthracis, Q5LD58, Q64U78, Bacillus anthracis, Bacillus cereus, A7I3S9, Q97GVI, Bacillus cereus, Desulfitobacterium A3DEB1, A5N7P5, hafniense, Desulfitobacterium B9E156, B812N8, hafniense, Bacteroides A9KSH6, B8J189, thetaiotaomicron, Bacteroides Q831F9, B0S1N3, vulgatus, Bacteroides fragilis, Q03EK4, Q7MXW0, Bacteroides fragilis, Campylobacter B2RGR2, B4EZV5, hominis, Clostridium acetobutylicum, A4VI36, Q88Q27, Clostridium thermocellum, Clostridium Q3K5K9, Q9HTE9, kluyveri, Clostridium kluyveri, Q9I138, Q88R12, Clostridium cellulolyticum, Clostridium Q4K5R9, Q4K4P6, phytofermentans, Desulfovibrio Q48CP3, Q48DU7, desulfuricans, Enterococcus faecalis, Q4ZNH2, Q3K6J0, Finegoldia magna, Pediococcus Q87WC1, Q4ZM83, ntosaceus, Porphyromonas gingivalis, Q88AD1, Q8Y1G1, Porphyromonas gingivalis, Proteus B2U7G7, Q03L77, mirabilis, Pseudomonas stutzeri, Q5M0B4 Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas syringae, Ralstonia solanacearum, Ralstonia pickettii, Streptococcus thermophilus, Streptococcus thermophilus 370 EIAGPGFIN Acinetobacter baumannii, B0VBN5, B2I0Y7, Acinetobacter baumannii, B7I1U9, B7H2A9, P54136 Acinetobacter baumannii, Q72X85, Q6HAS1, Acinetobacter baumannii, Bacillus Q81Q08, Q630N6, cereus, Bacillus thuringiensis, Bacillus Q5WB34, Q81JT7, cereus, Bacillus cereus, Bacillus Q9K6C1, Q6A5X8, clausii, Bacillus anthracis, Bacillus B9M252, C6E805, halodurans, Propionibacterium acnes, B5EEF0, Q0I3B0, Geobacter daltonii, Geobacter sp., A5UCH1, Q40L12, Geobacter bemidjiensis, Haemophilus P43832, Q7VP38, somnus, Haemophilus influenzae, A5UJ40, Q3KJB3, Haemophilus influenzae, C3KAH3, Q4KJK0, Haemophilus influenzae, B9DKQ7 Haemophilus ducreyi, Haemophilus influenzae, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens, Staphylococcus carnosus 371 EIFLRELISNA Desulfitobacterium hafniense Q24VT7 P14625 372 EIFLRELISNASDA Acinetobacter baylyi, Clostridium Q6FF82, Q0TU16, P14625 perfringens, Clostridium perfringens, Q0VV8, Q8XNC2 Clostridium perfringens 373 EIGGGSIRI Fusobacterium nucleatum Q8RGJ4 Q6PI48 374 EIGVASTKA Neisseria meningitidis, Neisseria Q9K1P9, Q9JWN9, Q06210 meningitidis, Neisseria gonorrhoeae Q5F584 375 EIKKAYRKLA Corynebacterium efficiens, Q8FNF5, Q8NNB4, Q8WW22 Corynebacterium glutamicum, Q6NG14 Corynebacterium diphtheriae 376 EKSPYLLQHA Bacillus subtilis, Bacillus subtilis P37512, P37509 Q8TB22 377 ELGGKSPLI Escherichia coli, Escherichia coli, Q0TKW0, B1J0W5, Q3SY69 Escherichia coli, Escherichia coli, P17445, B1XET7, Escherichia coli, Escherichia coli, A7ZWV5, B7L441, Escherichia coli, Escherichia coli, Q7AH91, B5Z1R1, Escherichia coli, Escherichia coli, B6I075, B7N8L4, Escherichia coli, Escherichia coli, B1LIJ8, Q8FKI8, Escherichia coli, Escherichia coli, B7UJG5, A7ZI51, Escherichia coli, Escherichia coli, B7MCD1, B7M2V6, Escherichia coli, Pseudomonas B7NK50, A4XPI6, mendocina, Pseudomonas C3K3D2, Q88AE9, fluorescens, Pseudomonas syringae, Q4ZM62, Q48CM6, Pseudomonas syringae, A4VKC2, Q2KB42, Pseudomonas savastanoi, B5ZUG3, B3PTE1, Pseudomonas stutzeri, Rhizobium C3MIE5, P54222, etli, Rhizobium leguminosarum, Q985M6 Rhizobium etli, Rhizobium sp., Rhizobium meliloti, Rhizobium loti 378 ELGGKSPLII Acinetobacter baumannii, A3M365, B2HV80, Q3SY69 Acinetobacter baumannii, B0V944, B71896, Acinetobacter baumannii, B7GYG4, Q6FDF8, Acinetobacter baumannii, B0VST2, B5Y007, Acinetobacter baumannii, Q3K5H4, B0KN18, Acinetobacter baylyi, Acinetobacter Q1IG69, Q88CVV7, baumannii, Klebsiella pneumoniae, A5WA96, B1J2K9 Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 379 ELGGKSPLIIF Pseudomonas aeruginosa, A6VEI4, Q9HTJ1, Q3SY69 Pseudomonas aeruginosa, B7V5R4, Q02DY9, Pseudomonas aeruginosa, Q4K4K8 Pseudomonas aeruginosa, Pseudomonas fluorescens 380 ELIASENFAS Clostridium novyi A0PZX4 P34896 381 ELLGRVVDALGN Acinetobacter baylyi, Acinetobacter Q6FFK2, B0VBP5, P25705 baumannii, Acinetobacter baumannii, B7I1W2, B2I100, Acinetobacter baumannii, A3M142, B7H296, Acinetobacter baumannii, A5WBA5, B0KRB0, Acinetobacter baumannii, B1JFU3, Q88BX2, Pseudomonas putida, Pseudomonas C3K1E8, B7V793, putida, Pseudomonas putida, Q02DF2, Q9HT18, Pseudomonas putida, Pseudomonas A6VF34, Q87TT2, fluorescens, Pseudomonas Q3K439, A4Y189, aeruginosa, Pseudomonas Q4ZL22, Q48BG3, aeruginosa, Pseudomonas Q4K3A7, Q1I215, aeruginosa, Pseudomonas A4VS64 aeruginosa, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas mendocina, Pseudomonas syringae, Pseudomonas savastanoi, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas stutzeri 382 ELNRKVLADLA Clostridium cellulolyticum, B8I169, Q30Y14, Q9BYC9 Desulfovibrio alaskensis, B8J4E1 Desulfovibrio desulfuricans 383 EMNLSETAF Bacillus halodurans Q9KG32 P30039 384 EMRQSLRII Pseudomonas aeruginosa, A6V4E7, Q02ND1, O75306 Pseudomonas aeruginosa, Q9I0J9 Pseudomonas aeruginosa 385 ENGMDVFRVFD Propionibacterium freudenreichii Q70AC7 P11498 386 ENIRRIAEV Bacteroides fragilis, Bacteroides Q5LES5, Q64VR1, Q95340 fragilis, Bacteroides thetaiotaomicron Q8AAQ1 387 ENLRWDAS Staphylococcus aureus, Q6GDJ1, A8Z5A4, Q8NE62 Staphylococcus aureus, P60336, P60337, Staphylococcus aureus, A6QK99, Q5HCU1, Staphylococcus aureus, Q2YWJ5, A5IW37, Staphylococcus aureus, Q2FV11, Q2FDP9, Staphylococcus aureus, A7X6Z3, A6U4Z2, Staphylococcus aureus, Q4L9D7, Q8CMY2, Staphylococcus aureus, Q5HL11 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 388 ENYVHRIGRTGR Listeria monocytogenes Q8Y7M8 Q9UJV9 389 EPGAEEKFK Lactobacillus reuteri, Lactobacillus B2G6W4, A5VJE8 P25685 reuteri 390 EPIGVCGQI Bacillus subtilis P71016 Q94788 391 EPTSGNTGI Escherichia coli, Escherichia coli P0ABK6, P0ABK5 P35520 392 EPTSGNTGIGLA Staphylococcus aureus, Q6GBX5, P63872, P35520 Staphylococcus aureus, Q6GJF8, P63871, Staphylococcus aureus, P63870, Q5HIG2, Staphylococcus aureus, Q8CMT6, Q5HRP1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 393 ERAYDIYSRLL Fusobacterium nucleatum, Q8RHJ8, Q30Z79, Q16740 Desulfovibrio alaskensis, A1VE85, Q72CE8, Desulfovibrio vulgaris, Desulfovibrio B8DNL4, B8IYM2 vulgaris, Desulfovibrio vulgaris, Desulfovibrio desulfuricans 394 ERAYDIYSRLLR Desulfovibrio maeticus C4XH03 Q16740 395 ERFSYYGMRAIL Bacillus subtilis P94408 P46059 396 ERGTFSHRH Staphylococcus haemolyticus, Q4L6C4, Q5HPC6, Q9ULD0 Staphylococcus epidermidis, Q8CP83, Q49XM5 Staphylococcus epidermidis, Staphylococcus saprophyticus 397 ERIPERWHA Bacillus subtilis, Pseudomonas P42234, Q9I1W8, P04040 aeruginosa, Rhizobium meliloti Q9X576 398 ERKTGARGLR Desulfovibrio vulgaris, Desulfovibrio vulgaris A1VE84, Q72CE7 O76031 399 ERKTGARGLRSI Streptococcus equi, Streptococcus B4U360, C0M9R7, O76031 equi, Streptococcus equi, C0MEW5, Q8DZ10, Streptococcus agalactiae, Q8E4L8, Q3K0K0, Streptococcus agalactiae, A2RF17, Q5XCM0, Streptococcus agalactiae, Q1JC93, Q1JM77, Streptococcus pyogenes, B5XL03, B9DU73, Streptococcus pyogenes, Q8DUI0, Q03LN0, Streptococcus pyogenes, Q5M5B0, Q5M0S4, Streptococcus pyogenes, A8AX69, A3CMV1, Streptococcus pyogenes, B5E6L2, B8ZLT1, Streptococcus uberis, Streptococcus B2IR87, C1CLR8, mutans, Streptococcus thermophilus, C1CFF2, P63792, Streptococcus thermophilus, P63791, C1C8G0, Streptococcus thermophilus, Q04JH9 Streptococcus gordonii, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 400 ERLEFLGDAV Bifidobacterium longum Q8G7H1 Q9NRR4 401 ESMLTGESVPV Enterococcus hirae P32113 Q9H7F0 402 ESVKAASELY Desulfovibrio vulgaris, Desulfovibrio A1VE01, Q72C58, P23434 vulgaris, Desulfovibrio alaskensis Q311A6 403 ESVKAASELYSPL Desulfovibrio vulgaris B8DP97 P23434 404 ESVRGKDVFIIQ Campylobacter jejuni Q9PP15 O60256 405 ETGGLSGKPL Rhizobium loti Q98689 Q02127 406 ETLGGTCLNVGC Pseudomonas aeruginosa Q9HUY1 P09622 407 ETMLGDVAV Ralstonia solanacearum Q8XX80 P26640 408 ETMLGDVAVAVH Corynebacterium jeikeium, Q4JWU8, Q8FN65, P26640 P Corynebacterium efficiens, Q6NFV0, Q8NN37 Corynebacterium diphtheriae, Corynebacterium glutamicum 409 ETRYRQRYLDLI Edwardsiella ictaluri, Proteus mirabilis C5BAR6, B4F0M6 Q15046 410 ETVGVGQSE Escherichia coli P27254 Q8IVH4 411 ETYGCQMNV Bacteroides vulgatus, A6KZJ2, A6LEM6, Q965Z6 Parabacteroides distasonis, Q8A2W0, Q650P7, Bacteroides thetaiotaomicron, Q5LJ70, Q7MAW4, Bacteroides fragilis, Bacteroides B2RKG6 fragilis, Porphyromonas gingivalis, Porphyromonas gingivalis 412 EVAKLFADAG Clostridium acetobutylicum Q97MT8 Q43252 413 EVEGLADLI Rhizobium meliloti, Rhizobium etli, Q92KW1, B3PS53, Q969Y2 Rhizobium leguminosarum, Q1MA18, Q2K2S0 Rhizobium etli 414 EVGPRDGLQNE Bacillus subtilis, Pseudomonas Q34873, P13703 Q8TB92 mevalonii 415 EVRGGGRKP Corynebacterium glutamicum, Q8NT08, A4QB10, Q9BYD3 Corynebacterium glutamicum, C3PKQ3 Corynebacterium aurimucosum 416 EVRGGGRKPW Bacillus clausii, Bacillus halodurans, Q5WLR1, Q9Z9L3, Q9BYD3 Bacillus licheniformis, Bacillus Q65PA6, A9VP78, weihenstephanensis, Bacillus Q6HPQ7, Q63H89, thuringiensis, Bacillus cereus, Bacillus Q81J41, B9IZJ5, cereus, Bacillus cereus, Bacillus A0R8I1, B7HQU5, thuringiensis, Bacillus cereus, Bacillus B7IT20, B7HJ49, cereus, Bacillus cereus, Bacillus C1ET40, Q81VS9, cereus, Bacillus anthracis, Bacillus Q73F95, B7JKC0, cereus, Bacillus cereus, Bacillus C3LJ83, C3P9Q6, anthracis, Bacillus anthracis, Bacillus P42921, A7ZQN9, subtilis, Bacillus methylotrophicus, A8F986, B8G1W7, Bacillus pumilus, Desulfitobacterium Q250N1, C4ZBD5, hafniense, Desulfitobacterium A3DJH3, B0RZU1, hafniense, Eubacterium rectale, P61054, P61055, Clostridium thermocellum, Finegoldia B8DB09, Q71WE7, magna, Listeria innocua, Listeria C1KZH9, A0ALW7 monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria welshimeri 417 EVTLLGQNVN Corynebacterium urealyticum, B1VDD8, A4QEV7, Q96SZ6 Corynebacterium glutamicum, Q8NP67, Q6NGR0, Corynebacterium glutamicum, Q8FPD5, Q4JV79, Corynebacterium diphtheriae, A6V0C9, Q51470, Corynebacterium efficiens, Q02SE8, Q48DN8, Corynebacterium jeikeium, Q4ZN97, Q4K5I3, Pseudomonas aeruginosa, Q3K6B7, Q87VY1, Pseudomonas aeruginosa, B2UFP3, Q8Y206, Pseudomonas aeruginosa, Q98BK3 Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas syringae, Ralstonia pickettii, Ralstonia solanacearum, Rhizobium loti 418 EVTLLGQNVNS Desulfitobacterium hafniense, Q24X58, Q39TA3, Q96SZ6 Geobacter metallireducens, B5EE49 Geobacter bemidjiensis 419 EWWNDLWLNE Streptomyces lividans Q11010 P15144 420 EYCLGPTHEE Desulfovibrio desulfuricans B8IZD1 Q7L3T8 421 EYCLGPTHEEA ptoclostridium difficile Q18CD2 Q7L3T8 422 EYLARWFD Corynebacterium efficiens, Q8FTA8, Q8N098 P21399 Corynebacterium glutamicum 423 EYRGYDSAG Fusobacterium nucleatum Q8RG65 Q06210 424 EYSRSGNPTR Helicobacter pylori, Helicobacter P56069, Q1M0P5, P32929 pylori, Helicobacter pylori Q9ZMW7 425 FALCGFANF Escherichia coli, Escherichia coli P33021, P33024 O00377 426 FALCGFANFSSI Bacillus subtilis O32115 O00377 427 FALKPMNCPGH Rhizobium loti, Rhizobium sp., Q98LR2, C3MB49, A2RTX5 Rhizobium etli, Rhizobium etli, Q2K859, B3PNV4, Rhizobium leguminosarum, B5ZQK2, Q92Q130 Rhizobium meliloti 428 FANFSSIGI Bacillus subtilis, Escherichia coli, P39141, P0AFF2, O00377 Escherichia coli P0AFF3 429 FAPEVAWVT Bacillus cereus, Bacillus cereus, Q81IE9, Q63GI2, P07814 Bacillus thuringiensis, Bacillus cereus, Q6HNZ7, Q73E50, Bacillus thuringiensis, Bacillus A0R9A0, Q81Z76, anthracis, Eubacterium rectale, C4ZC24, A0Q213, Clostridium novyi, Clostridium B8I5R4, C3KUV8, cellulolyticum, Clostridium botulinum, B1L224, B1IF12, Clostridium botulinum, Clostridium A7GIT0, C1FM10, botulinum, Clostridium botulinum, A51768, A7FYU0, Clostridium botulinum, Clostridium Q9L4Q8, A9KL35, botulinum, Clostridium botulinum, Q18CD7, C4Z1D7 Clostridium sticklandii, Clostridium phytofermentans, ptoclostridium difficile, Eubacterium eligens 430 FCAGADLKER Bacillus subtilis O34893 Q13825 431 FCKEFNERTKD Selenomonas ruminantium Q84IF5 Q9Y3B7 432 FDPLDGSSNID Acinetobacter baumannii, A3M7W9, B0VDK0, P09467 Acinetobacter baumannii, B0VT80, B2HWU2, Acinetobacter baumannii, A1VD23, Q72AZ9, Acinetobacter baumannii, C6BTU7, Q30ZN0, Desulfovibrio vulgaris, Desulfovibrio Q9JZH1, A1KTU6, vulgaris, Desulfovibrio salexigens, A1IRQ3, A9LYX9, Desulfovibrio alaskensis, Neisseria Q5F8C3, B4RLD4, meningitidis, Neisseria meningitidis, A4VGC9, Q02EQ6, Neisseria meningitidis, Neisseria A4XPL2, Q9HU73, meningitidis, Neisseria gonorrhoeae, B7V3K3, A6VDM7, Neisseria gonorrhoeae, B1J2P7, B0KM65, Pseudomonas stutzeri, Pseudomonas A5WA74, Q1I3Q0, aeruginosa, Pseudomonas Q88CY9, Q3KJG0, mendocina, Pseudomonas C3K7D6, Q4KJP6, aeruginosa, Pseudomonas Q87UX4, Q4ZZI0, aeruginosa, Pseudomonas Q48PL3, B2U8C4, aeruginosa, Pseudomonas putida, Q8XXI7, B2FU10, Pseudomonas putida, Pseudomonas B4SR24 putida, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi, Ralstonia pickettii, Ralstonia solanacearum, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 433 FDRERIPERVVHA Pseudomonas aeruginosa, Q59635, P46206 P04040 Pseudomonas syringae 434 FDRERIPERVVHA Helicobacter pylori, Helicobacter Q9ZKX5, P77872 P04040 KG pylori 435 FDRILASRMGV Haemophilus ducreyi Q8GNC1 Q01813 436 FDRILLDAPCS Escherichia coli Q0TCH3 Q8TEA1 437 FDTAPTGHT Escherichia coli, Escherichia coli P52145, P08690 Q43681 438 FEYVYFARPDS Escherichia coli, Rhizobium etli P0AG16, P77935 Q06203 439 FFYPLDFTFVCPT Clostridium pasteurianum P23161 Q06830 El 440 FGHPEVYIL Bacillus pseudofirmus, Bacillus sp. Q04440, P16262 P00395 441 FGHPEVYILILP Bacillus subtilis P24010 P00395 442 FGICLGHQL Listeria monocytogenes, Listeria Q71YI0, Q8Y664, P27708 monocytogenes, Listeria innocua Q92AH2 443 FGLGAEVGIST Arcobacter butzleri A8EVN0 P54886 444 FGLPAENAA Fusobacterium nucleatum, Q8RIQ3, Q24SP5, Q15031 Desulfitobacterium hafniense, B8FUR3, Q182K8 Desulfitobacterium hafniense, ptoclostridium difficile 445 FGMGCFWGAER Pseudomonas aeruginosa, Q02EZ9, Q9HUF1, Q9UJ68 Pseudomonas aeruginosa, B7V3B1, Q4ZM24, Pseudomonas aeruginosa, Q92SY7 Pseudomonas syringae, Rhizobium mel iloti 446 FGMIPEFVGR Clostridium phytofermentans A9KSX1 O76031 447 FGSFDKFKE Pseudomonas aeruginosa, P53641, Q88PD5, P04179 Pseudomonas putida, Pseudomonas P09223 putida 448 FGTGAVKITPAHD Lactobacillus casei, Clostridium P36420, Q97GG8, P26640 acetobutylicum, Clostridium tetani, Q891R5, Q8XJ42 Clostridium perfringens 449 FGTIDSWLIW Streptomyces avermitilis Q827G1 Q14409 450 FGWDCHGLP Corynebacterium diphtheriae, Q6NGD7, Q4JW85 P41252 Corynebacterium jeikeium 451 FHAIYWPAFL Campylobacter jejuni, Helicobacter Q9PP85, Q9ZKG9, Q96GW9 pylori, Helicobacter pylori P56127 452 FHSLEDRIVK Methylobacterium sp., Fusobacterium B0UFI0, Q8R6F5, A6NJ78 nucleatum, ptoclostridium difficile, Q182Z2, A3DE34, Clostridium thermocellum, Clostridium A6LTS0, B2TS30, beijerinckii, Clostridium botulinum, B2V4W0, Q89464, Clostridium botulinum, Clostridium Q97H81, B1LYT9, tetani, Clostridium acetobutylicum, B7KU77, C5ATZ5, Methylobacterium radiotolerans, A9WV37, B1Z8U3, Methylobacterium extorquens, B8IMX2, A1KVM4, Methylobacterium extorquens, Q9JSY9, Q9KOZ0, Methylobacterium extorquens, B4RQD7, A9M2I4, Methylobacterium populi, Q5F6K7 Methylobacterium nodulans, Neisseria meningitidis, Neisseria meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria gonorrhoeae 453 FHSLEDRIVKRF Rhizobium loti Q98KA5 A6NJ78 454 FIAGADINM Citrobacter koseri, Enterobacter sp., A8ADP2, A4WCVV6, P40939 Escherichia coli, Escherichia coli, Q8FFG4, B7LBJ5, Escherichia coli, Escherichia coli, A7ZPF8, B61604, Escherichia coli, Escherichia coli, B7M6M2, Q8XCP2, Escherichia coli, Escherichia coli, B7NP24, B7N5V2, Escherichia coli, Escherichia coli, B1LME7, B7MGV7, Escherichia coli, Escherichia coli, Q1R972, A1ADI8, Escherichia coli, Escherichia coli, A8A2L0, B7UFZ8, Escherichia coli, Escherichia coli, B1IXA5, B7MY16, Escherichia coli, Escherichia coli, B5YXY4, Q0TFA6, Escherichia coli, Escherichia coli, P77399, B1X9L4, Escherichia coli, Escherichia C4ZVN2, B7LLD0, fergusonii, Klebsiella pneumoniae, B5XWV2, A6TC19 Klebsiella pneumoniae 455 FIGRSNVGKSSLI Parabacteroides distasonis, A6LBY4, Q7MX68, Q8N3Z3 Porphyromonas gingivalis, B2RL89 Porphyromonas gingivalis 456 FITHLHGDH Lactobacillus casei, Lactobacillus B3WE54, Q039J0 Q9H777 casei 457 FITPVPGGVGPMT Listeria monocytogenes, Listeria Q71ZW2, C1L2R6 P11586 monocytogenes 458 FITPVPGGVGPMT Haemophilus parasuis B8F605 P11586 VAMLMQ 459 FKQLLMVGG Acinetobacter baumannii, B0V550, B2HYL7, Q6PI48 Acinetobacter baumannii, B7I8M5, B7GWN1, Acinetobacter baumannii, A3M8Q6, B0VRC7, Acinetobacter baumannii, A7GT84, B9IYX5, Acinetobacter baumannii, B7HQG0, Q730D1, Acinetobacter baumannii, Bacillus Q634E3, B7HE37, cytotoxicus, Bacillus cereus, Bacillus B7IIR4, Q81LI7, cereus, Bacillus cereus, Bacillus C3P990, Q6HDC3, cereus, Bacillus cereus, Bacillus C1ESU7, A0RJ11, cereus, Bacillus anthracis, Bacillus B7JPY8, C3L608, anthracis, Bacillus thuringiensis, Q817X8, A9VIM8, Bacillus cereus, Bacillus thuringiensis, C4LIW2, P56459, Bacillus cereus, Bacillus anthracis, Q1CTQ7, B6JLK1, Bacillus cereus, Bacillus Q9ZLL9 weihenstephanensis, Corynebacterium kropnstedtii, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori 460 FKQLYDKGL Bifidobacterium longum Q8G3I2 P41252 461 FLKHIERTR Clostridium botulinum B2TK70 A4D1E9 462 FLRELISNASDA Aeromonas hydrophila, Aeromonas A0KL53, A4SLY0, P14625 salmonicida, Bacillus lichen iformis Q65CZ5 463 FLRHIERCR Propionibacterium acnes Q6A9H8 Q9H4K7 464 FLSNGPGDP Haemophilus ducreyi, Neisseria Q7VP66, Q9JXX4, P27708 meningitidis, Neisseria meningitidis, Q9JVZ6, Q50983, Neisseria gonorrhoeae, Q87WP3, Q88DU5, Pseudomonas syringae, P38098, Q8XZ85, Pseudomonas putida, Pseudomonas Q981A7 aeruginosa, Ralstonia solanacearum, Rhizobium loti 465 FLSNGPGDPA Acinetobacter baylyi, Desulfovibrio Q6F8M7, A1VA26, P27708 vulgaris, Desulfovibrio vulgaris, Q726J4, Q8FLB1, Escherichia coli, Escherichia coli, P0A6F2, P0A6F1, Escherichia coli, Rhizobium meliloti Q92N95 466 FLSQSGETAD Bacillus subtilis, Bacillus subtilis EOU070, P0CI73 Q06210 467 FLWVVDFPL Uncultured termite B1GZY6 Q6PI48 468 FMPVGTQAT Clostridium thermocellum, A3DE13, Q03ER2, Q9BXR0 Pediococcus ntosaceus, A4VW51, A4W2F8, Streptococcus suis, Streptococcus B1I9B4, Q8E1F9, suis, Streptococcus pneumoniae, Q8E6X6, Q3K2Y7, Streptococcus agalactiae, A8AUL3, Q5M2K9, Streptococcus agalactiae, Q03IQ5, Q5LY05, Streptococcus agalactiae, A3CK60, B9DVZ9, Streptococcus gordonii, C0MAH5, C1CN05, Streptococcus thermophilus, Q1JIT0, P0DF87, Streptococcus thermophilus, Q48VG9, A2RCC9, Streptococcus thermophilus, Q1JNN4, Q1JDS0, Streptococcus sanguinis, P66910, P0DF86, Streptococcus uberis, Streptococcus C0MEV8, Q9A1L6, equi, Streptococcus pneumoniae, Q1J8P1, B5XJL3, Streptococcus pyogenes, C1CGY8, B2IMN3, Streptococcus pyogenes, P66908, B5E2X9, Streptococcus pyogenes, P66907, B8ZPB8, Streptococcus pyogenes, Q04163, C1CTW4, Streptococcus pyogenes, C1CAA6, Q5XE18, Streptococcus pyogenes, Q8DVZ3 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus mutans 469 FMQKEIFEQP Ralstonia solanacearum Q8Y303 Q06210 470 FNDDIQGTA Pseudomonas aeruginosa, Q9HYD5, Q02QW0, Q16798 Pseudomonas aeruginosa, B7UWK9, A6V1V5 Pseudomonas aeruginosa, Pseudomonas aeruginosa 471 FNDDIQGTASVAV Pseudomonas savastanoi, Q48LC8, Q4ZW63, Q16798 Pseudomonas syringae, Q87Y79 Pseudomonas syringae 472 FPAGILQAPFY Lactobacillus helveticus O52071 Q60344 473 FPGYTHLQRAQPI Bacillus pumilus A8FG69 P04424 474 FPHHENEIAQ Corynebacterium kropnstedtii, C4LH17, Q82GD0, Q9HA77 Streptomyces avermitilis, B1VS94, Q9L0Q6 Streptomyces griseus, Streptomyces coelicolor 475 FPLLTTKRV Bacillus cytotoxicus, Bacillus A7GP90, Q6HJC7, P04818 thuringiensis, Bacillus thuringiensis, A0RDL9, Q81R23, Bacillus anthracis, Bacillus cereus, Q81E05, Q738X7, Bacillus cereus, Bacillus cereus, Q63BV5, Q834R3, Enterococcus faecalis, Pediococcus Q03F96 ntosaceus 476 FPLWWQTGSGT Bacillus subtilis, Methylobacterium P07343, Q8KTE1, P07954 Q extorquens, Neisseria meningitidis, Q9JTR0, Q885V0, Pseudomonas syringae, Q88M20, Q8X0E8 Pseudomonas putida, Ralstonia solanacearum 477 FQALRIFVN Rhizobium etli, Rhizobium Q2K6B3, Q1ME25, A6NJ78 leguminosarum, Rhizobium sp., C3MEN7, B3PTW8, Rhizobium etli, Rhizobium meliloti, Q92NL4, B5ZWK2, Rhizobium leguminosarum, C6ARU7 Rhizobium leguminosarum 478 FRASPRQSD Helicobacter hepaticus Q7VFS3 O75251 479 FRASPRQSDVMI Helicobacter pylori, Helicobacter B6JNA1, B5Z8Q6, O75251 pylori, Helicobacter acinonychis, Q17Z53, O25851, Helicobacter pylori, Helicobacter B2UV25, Q1CS00, pylori, Helicobacter pylori, Q9ZJW6 Helicobacter pylori 480 FRPWTIRQYAGFS Propionibacterium freudenreichii P11653 P22033 T 481 FSMCEHHLVPF Bacillus halodurans Q9KCC7 P30793 482 FSMDGDIAPL Escherichia coli, Ralstonia pickettii, B7LC58, B2UBJ3, Q75600 Ralstonia solanacearum, Q8XZC3, B2FLM5, Stenotrophomonas maltophilia, B4SM82 Stenotrophomonas maltophilia 483 FTFGPTFRAE Lactobacillus plantarum, Lactobacillus Q88Y40, A8YVJ7, Q96159 helveticus, Lactobacillus delbrueckii, P54262, Q74JA9, Lactobacillus johnsonii, Lactobacillus Q043G9 gasseri 484 FTSGATESNN Aeromonas salmonicida, Neisseria A4SP14, Q9JYY0 Q9Y697 meningitidis 485 FTSGGTESN Bacillus subtilis P38033 Q96115 486 FTSGGTESNN Lactobacillus delbrueckii, Rhizobium P31672, P55690 Q96115 sp. 487 FTTWADTGDF Pseudomonas syringae, Q884H4, Q4ZV64, P37837 Pseudomonas syringae, Q48KH5 Pseudomonas savastanoi 488 FVCLGNICRSP Staphylococcus haemolyticus, Q4L7J1, Q6GFH6, P24666 Staphylococcus aureus, Q49Y56, Q6G853, Staphylococcus saprophyticus, Q7A0I2, Q2FX12, Staphylococcus aureus, P0Q5D2, Q7A4S1, Staphylococcus aureus, Q5HEP3, Q99T00, Staphylococcus aureus, Q2FFL4, Q2YU46, Staphylococcus aureus, Q8CNQ1, Q5HN53 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 489 FVPNDMQVGQTG Pseudomonas aeruginosa Q9HZP7 P13804 KIVAP 490 FWVGPEAPL Rhizobium meliloti Q92RL0 P22102 491 FYAAVEMRDNP Aeromonas hydrophila, Citrobacter A0KHD5, A8AKQ2 Q9UBT6 koseri 492 FYDGPPFATGLPH Pseudomonas fluorescens Q8L1B1 P41252 YGHIL 493 FYGPFRDAA Bacillus subtilis, Bacillus halodurans P30950, Q9K8G2 P13716 494 FYQASTSELYG Rhizobium fredii, Rhizobium sp. O85713, P55354 Q60547 495 GACVNAPMV Rhizobium meliloti P56909 P19404 496 GAFTGEISP Bacillus licheniformis, Bacillus subtilis, Q65EN0, P27876, P60174 Bacillus halodurans, Listeria innocua, Q9K715, Q928I1, Listeria monocytogenes, Listeria Q71WW9, Q8Y4I3 monocytogenes 497 GAFTGEISPGM Geobacter metallireducens Q39U97 P60174 498 GAFYGPKIDI Helicobacter hepaticus Q7VJO9 P26639 499 GAFYGPKIDIKI Campylobacter lari B9KEB1 A2RTX5 500 GAGDQGLMFG Lactobacillus sakei, Lactobacillus Q38YF8, B2GDG2, Q00266 fermentum, Lactobacillus helveticus, A8YWU7, Q5FIN8, Lactobacillus acidophilus, Q74K54, Q837P9, Lactobacillus johnsonii, Enterococcus C6E2L2, B8DFQ7, faecalis, Geobacter sp., Listeria Q71Z03, C1KVW3, monocytogenes, Listeria Q8Y6M0, Q92AZ5, monocytogenes, Listeria A0AJB9, Q98A80, monocytogenes, Listeria B9DN19, A3CNY4, monocytogenes, Listeria innocua, Q8DT23, Q5LZI0, Listeria welshimeri, Rhizobium loti, A8AWW6, Q5M434, Staphylococcus carnosus, A4W351, A4VWU8, Streptococcus sanguinis, COM9M7, B4U228, Streptococcus mutans, Streptococcus C0MCM1, B9DSM6, thermophilus, Streptococcus gordonii, Q8DQH0, B2INE5, Streptococcus thermophilus, B1IAT8, B5E364, Streptococcus suis, Streptococcus Q04LE0, B8ZNB7, suis, Streptococcus equi, Q8E5Y0, C1C6A5, Streptococcus equi, Streptococcus C1CJL0, B5XM14, equi, Streptococcus uberis, A2RE06, Q1JL80, Streptococcus pneumoniae, Q1JB36, Q8P0G6, Streptococcus pneumoniae, P0DF55, P0DF54, Streptococcus pneumoniae, Q5XBJ6, Q485U7, Streptococcus pneumoniae, C1CQM2, Q97RN9, Streptococcus pneumoniae, Q8E0A3, Q3K1M7, Streptococcus pneumoniae, Q99Z77, Q1J626, Streptococcus agalactiae, C1CDB0, Q1JGA1 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pyogenes 501 GAGDQGLMFGYA Acinetobacter baylyi, Acinetobacter Q6FA06, B0VC98, Q00266 baumannii, Acinetobacter baumannii, A3M4V2, B0VR30, Acinetobacter baumannii, B2HYY9, Q03QA4, Acinetobacter baumannii, A5GA66, Q39W48, Lactobacillus brevis, Geobacter P61946, AIK598, uraniireducens, Geobacter A9M1V8, Q9JW6, metallireducens, Geobacter Q9JY09, Q5FAC0, sulfurreducens, Neisseria B4R036, Q8Y347, meningitidis, Neisseria meningitidis, B2UD22, Q9X4Q2 Neisseria meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria gonorrhoeae, Ralstonia solanacearum, Ralstonia pickettii, Streptomyces sctabilis 502 GAGDQGLMFGYA Pediococcus ntosaceus, Q03GG8, Q8NVZ9, Q00266 T Staphylococcus aureus, A8Z4L2, Q2G1W4, Staphylococcus aureus, Q6G8E3, A6QHX0, Staphylococcus aureus, Q5HEY9, Q2YTK1, Staphylococcus aureus, Q2FFV6, P50307, Staphylococcus aureus, P66767, P66766, Staphylococcus aureus, A5ITV6, A6U2Q1, Staphylococcus aureus, A7X3N2, Q6GFR6, Staphylococcus aureus, Q4L7C7, Q49YL6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus saprophyticus 503 GAGDQGLMFGYA Lactobacillus reuteri, Lactobacillus B2G8G3, A5VL29, Q00266 TDET reuteri, Staphylococcus epidermidis, Q8CNT5, Q5HNB8, Staphylococcus epidermidis, Q827Q0 Streptomyces avermitilis 504 GAGGQHVNKT Methylobacterium sp., B0UAV4, B8IUB4, Q75570 Methylobacterium nodulans, A9W1A4, B7L246, Methylobacterium extorquens, B1Z914, B1M766 Methylobacterium extorquens, Methylobacterium populi, Methylobacterium radiotolerans 505 GAGGQHVNKTDS Pseudomonas stutzeri A4VPB9 Q75570 A 506 GAGHFVKMVHNG Bacillus licheniformis P52207 P52209 1EY 507 GAGISTESGIPDY Streptomyces coelicolor Q9RL35 Q9Y6E7 R 508 GAGKTTVGR Acinetobacter baumannii, B0V8M8, B0V033, Q81Y07 Acinetobacter baumannii, Q6F7E4, Q8XV61, Acinetobacter baylyi, Ralstonia A8AXY8 solanacearum, Streptococcus gordonii 509 GAGVSAESG Pseudomonas aeruginosa Q9I4L0 Q9NXA8 510 GAGVSAESGVPT Ralstonia solanacearum Q8Y015 Q9NXA8 FR 511 GAHIYVCGDA Neisseria meningitidis, Neisseria A1KU06, Q9JUD8, P16435 meningitidis, Neisseria meningitidis, A9LZ73, Q9J545 Neisseria meningitidis 512 GAHTDSPCLRVK Pseudomonas stutzeri, Pseudomonas A4VJG1, A4XRN0, Q9ULA0 mendocina, Pseudomonas syringae, Q4ZW15, C3K0D7, Pseudomonas fluorescens, Q48L80, Q87YC5, Pseudomonas savastanoi, Q3KFM3, Q02Q78, Pseudomonas syringae, B0KTU0, A6V2H4, Pseudomonas fluorescens, Q1IDE6, Q9HYZ3, Pseudomonas aeruginosa, B7V7X2, B1J1S3, Pseudomonas putida, Pseudomonas Q88M44, A5W7K3 aeruginosa, Pseudomonas entomophila, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 513 GAHVNPAVT Haemophilus influenzae O86231 P30301 514 GANAILGVS Enterococcus faecalis, Enterococcus E6ER18, P0DM31, P06733 faecalis, Enterococcus hirae, Q8GR70, Q8DT59, Streptococcus mutans, Streptococcus B9DRR9, Q1JML5, uberis, Streptococcus pyogenes, Q1JCN8, B5XKM7, Streptococcus pyogenes, P0DA95, Q48UF7, Streptococcus pyogenes, A2RFE3, Q1J7I5, Streptococcus pyogenes, P69951, Q1JHQ6, Streptococcus pyogenes, P0DA94, P69949, Streptococcus pyogenes, Q5XD01, P64081, Streptococcus pyogenes, Q3K2B2, P64080, Streptococcus pyogenes, A4W2T1, C0MH89, Streptococcus pyogenes, B4U2B8, C0M6K5, Streptococcus pyogenes, C1CRM6, C1CKJ0, Streptococcus pyogenes, C10EB3, Q97QS2, Streptococcus pyogenes, B8ZPW9, B1IBR3, Streptococcus agalactiae, C1C7C0, B5E4P1, Streptococcus agalactiae, A3CMA7, Q8DPS0, Streptococcus agalactiae, B2IPX8, Q04KG2 Streptococcus suis, Streptococcus equi, Streptococcus equi, Streptococcus equi, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 515 GANAILGVSLA Bifidobacterium longum, B3DSV2, Q8G5I9 P06733 Bifidobacterium longum 516 GAPGSGKGT Porphyromonas gingivalis, Q7MW54, B2RIY8 Q9UIJ7 Porphyromonas gingivalis 517 GAPNAGKSTL Rhizobium loti Q985A5 Q75616 518 GAPPHGGIA Propionibacterium acnes Q6A8J1 Q6PI48 519 GAQWGDEGKGK Bifidobacterium longum, Q8G6T9, B3DNT3, Q8N142 Bifidobacterium longum, B7GT29, A0ZZG5, Bifidobacterium longum, Q9RHX5, B0UJ78, Bifidobacterium adolescentis, B8DVC2, Q8FMB0, Corynebacterium ammoniagenes, Q6NF38, Q8NM16, Methylobacterium sp., Bifidobacterium A4QHG2, C3PJK0, animalis, Corynebacterium efficiens, Q4JXT3, B1VHT9, Corynebacterium diphtheriae, Q31769, B8DQ18, Corynebacterium glutamicum, A1V9U1, Q725K9, Corynebacterium glutamicum, B8J4N1, B2GL12, Corynebacterium aurimucosum, B1M1K0, B7L289, Corynebacterium jeikeium, B1Z962, B8IPM5, Corynebacterium urealyticum, C5C8H9, A5VFF3 Desulfovibrio alaskensis, Desulfovibrio vulgaris, Desulfovibrio vulgaris, Desulfovibrio vulgaris, Desulfovibrio desulfuricans, Kocuria rhizophila, Methylobacterium radiotolerans, Methylobacterium extorquens, Methylobacterium populi, Methylobacterium nodulans, Micrococcus luteus, Sphingomonas wittichii 520 GAQWGDEGKGK Geobacter sulfurreducens, Geobacter Q747F9, Q39QK1, Q8N142 VVD metallireducens, Geobacter daltonii, B9M1R2, A5GC19, Geobacter uraniireducens, Geobacter B3EAS4, C6DZQ7, lovleyi, Geobacter sp., Geobacter B5ECF3 bemidjiensis 521 GASGDLAPL Clostridium tetani, Streptococcus Q891Q1, A3CL24, P42357 sanguinis, Streptococcus gordonii, A8AZ70, A2RGS5, Streptococcus pyogenes, Q8NZ46, Q5X9K4, Streptococcus pyogenes, B5XIY2, P58083, Streptococcus pyogenes, P0DB75, P0DB74 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 522 GASGDLAPLSH Streptomyces globisporus Q8GMG0 P42357 523 GASGDLAPLSHLA Bacillus clausii, Bacillus subtilis, Q5WAZ6, P10944, P42357 L Staphylococcus saprophyticus Q4A173 524 GAVKITPAHD Bacillus licheniformis, Bacillus Q65GK8, Q9K8G8, P26640 halodurans, Bacillus subtilis, Bacillus Q05873, Q5WEQ4, clausii, Listeria innocua, Listeria Q92BG2, Q8Y6X9, monocytogenes, Listeria Q71ZB6 monocytogenes 525 GCCPGGTASN Bacillus subtilis O34524 Q12908 526 GCFWGAERKFW Methylobacterium sp., B0UCG5, B8IJD1, Q9UJ68 Methylobacterium nodulans, B1W2P8 Streptomyces griseus 527 GCIPSKALL Bacillus subtilis P54533 P09622 528 GCMKGRTMYVIPF Clostridium thermocellum A3DJE3 P35558 SMGP 529 GCMKGRTMYVIPF Geobacter sulfurreducens Q746Y3 P35558 SMGPLGSP 530 GDADVMVAGG Escherichia coli, Escherichia coli, P0AAI5, P0AAI6, Q9NUVU1 Escherichia coli P0AAI7 531 GDADVMVAGGT Rhizobium meliloti P56902 Q9NUVU1 532 GDDEAMFID Parabacteroides distasonis A6L8C6 Q15046 533 GDGAANQGQ Rhizobium meliloti Q9R9N5 P08559 534 GDGAFYGPKID Bacillus subtilis, ptoclostridium P18256, Q18968, A2RTX5 difficile, Clostridium thermocellum, A3DET1, Q891T0, Clostridium tetani, Clostridium B1IMV3, B1L0T7, botulinum, Clostridium botulinum, C3KTK0, A5I6L8, Clostridium botulinum, Clostridium A7FY87, C1FKN0, botulinum, Clostridium botulinum, A7GI05, A5N258, Clostridium botulinum, Clostridium B9E5W0, A0PZN1, botulinum, Clostridium kluyveri, B8J4E4, Q30Y11, Clostridium kluyveri, Clostridium A1VBB4, Q728R5 novyi, Desulfovibrio desulfuricans, Desulfovibrio alaskensis, Desulfovibrio vulgaris, Desulfovibrio vulgaris 535 GDGAFYGPKIDI Desulfovibrio salexigens C6BRH1 A2RTX5 536 GDGAFYGPKIDIK Desulfovibrio maeticus, Desulfovibrio C4XL11, B8DPN2, A2RTX5 vulgaris, Geobacter bemidjiensis, B5EBX9, C6DYJ5, Geobacter sp., Geobacter Q74D04 sulfurreducens 537 GDGIARVHG Desulfovibrio vulgaris, Desulfovibrio Q72E02, AlVFJ3 P25705 vulgaris 538 GDGIARVHGL Bacillus pumilus, Bacillus A8FIB4, Q65DX2, P25705 licheniformis, Bacillus A7Z9Q2, P37808, methylotrophicus, Bacillus subtilis, B8FZ36, Q24MN9 Desulfitobacterium hafniense, Desulfitobacterium hafniense 539 GDGIGPEIS Bacteroides thetaiotaomicron, Q8A6M0, P54354, P50213 Bacteroides fragilis, Bacteroides Q5LAB4 fragilis 540 GDGVNDAPAL Bacillus pseudofirmus, Listeria P30336, P58414, Q14983 monocytogenes, Rhizobium Q9X5V3, Q4A0G1, leguminosarum, Staphylococcus P20021, Q6GIX1, saprophyticus, Staphylococcus P37386 aureus, Staphylococcus aureus, Staphylococcus aureus 541 GDIIIDGGN Citrobacter amalonaticus, Citrobacter P41581, P41582, P52209 koseri, Citrobacter freundii, P41583, P00350, Escherichia coli, Escherichia coli, P37754, P41574, Escherichia vulneris, Klebsiella P41576, P41577, pneumoniae, Raoultella terrigena, P41575 Raoultella planticola 542 GDMDFKIAGT Desulfovibrio alaskensis, Q30WI5, B8J1X9 Q8TCS8 Desulfovibrio desulfuricans 543 GDRVAIYMP Streptomyces coelicolor Q9X928 Q9NUB1 544 GDRVAVMLP Bacillus subtilis P94547 Q68CK6 545 GDVLVLTKPLGT Eubacterium acidaminophilum Q9L473 P49903 546 GDWKGYTGK Haemophilus ducreyi Q7VNR9 P06744 547 GEEQVKIWRRS Clostridium phytofermentans A9KNQ1 P15259 548 GEERCIACKLCEA Neisseria meningitidis, Neisseria Q7DDS1, A1KRT1, O00217 meningitidis, Neisseria gonorrhoeae, Q5F623, Q9JQM2, Neisseria meningitidis, Ralstonia Q8XXQ9 solanacearum 549 GEIVSADSMQ Leuconostoc mesenteroides Q03VI2 Q9H3H1 550 GENGAGKST Clostridium tetani Q89712 Q9NUQ8 551 GEPVSAEDL Proteus mirabilis B4ET09 P11586 552 GERAYDIYSRLL Lactobacillus salivarius, Haemophilus Q1WTA8, B8F822 Q16740 parasuis 553 GEVMAIGRT Bacillus subtilis, Lactobacillus P25994, A8YVZ3, P31327 helveticus, Lactobacillus delbrueckii, Q047M8, Q5FJC0, Lactobacillus acidophilus, Q74J34, B2GD06, Lactobacillus johnsonii, Lactobacillus Q038Z2, B3WEF5, fermentum, Lactobacillus casei, B2G564, A5VHN6, Lactobacillus casei, Lactobacillus Q8RG86, Q4L5Q5, reuteri, Lactobacillus reuteri, P63739, P63740, Fusobacterium nucleatum, A6U122, A7X1F4, Staphylococcus haemolyticus, A5Is88, Q2FHN5, Staphylococcus aureus, A8Z3P0, Q5HGM9, Staphylococcus aureus, A6QGA4, Q2FZ72, Staphylococcus aureus, Q6GA10, Q5HPY8, Staphylococcus aureus, Q8CPJ4, Q6GHN2, Staphylococcus aureus, Q2YXG5, P58940, Staphylococcus aureus, Q49WY4, B9DRV7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Streptococcus uberis 554 GEVMAIGRTFEES Bacillus caldolyticus P46537 P31327 555 GEVTEINEA Methylobacterium nodulans B8IU03 P23434 556 GFCHGVLNTDNM Aeromonas salmonicida A4SHK8 Q9BVL4 S 557 GFILDGFPR Lactobacillus johnsonii, Lactobacillus Q74L69, Q046A5, Q5TCS8 gasseri, Lactobacillus delbrueckii, Q04BZ4, B5EFS1, Geobacter bemidjiensis, Geobacter C6E4N6 sp. 558 GFLLDGFPRTV Bacillus methylotrophicus, Bacillus A7Z0Q9, P16304 P54819 subtilis 559 GFPGETDQDF Haemophilus somnus, Rhizobium Q0I3Z1, Q92SI7 Q5W42 meliloti 560 GFPSVGKST Lactobacillus delbrueckii, Q04611, Q1GAM3, P55039 Lactobacillus delbrueckii, Q03F34 Pediococcus ntosaceus 561 GFPSVGKSTLLS Lactobacillus reuteri, Lactobacillus B2G6R9, A5VJ99, Q9Y295 reuteri, Lactobacillus fermentum B2GBD0 562 GFRGEALASI Lactobacillus delbrueckii, Q1G939, Q048Y5, P40692 Lactobacillus delbrueckii, Q74KW0, Q035Z3, Lactobacillus johnsonii, Lactobacillus B3W9W3, Q045Q4, casei, Lactobacillus casei, Q8XWB1, B1H0C7 Lactobacillus gasseri, Ralstonia solanacearum, Uncultured termite 563 GFRGEALASIS Aeromonas hydrophila, Aeromonas A0KGR9, A45R27, P40692 salmonicida, Lactobacillus Q5FLX4, A8YTI0, acidophilus, Lactobacillus helveticus, A8AMN1, C3KX34, Citrobacter koseri, Clostridium B1IM67, A7FUK9, botulinum, Clostridium botulinum, A7GE44, B1KSA2, Clostridium botulinum, Clostridium C1FNT8, C5BDM9, botulinum, Clostridium botulinum, A4W5R1, A1AJ76, Clostridium botulinum, Edwardsiella Q0T9M3, B7MKX4, ictaluri, Enterobacter sp., Escherichia P23367, B1XDS1, coli, Escherichia coli, Escherichia coli, C5A1G1, B6I274, Escherichia coli, Escherichia coli, A8A7R4, B7UQH9, Escherichia coli, Escherichia coli, A7ZV39, B7M8T0, Escherichia coli, Escherichia coli, Q8XDN4, B1LQJ0, Escherichia coli, Escherichia coli, B5Z2H6, B7MSY3, Escherichia coli, Escherichia coli, Q8FAK9, B1IT36, Escherichia coli, Escherichia coli, B7LLV2, B7LC24, Escherichia coli, Escherichia coli, B7NGA4, A5UB71, Escherichia fergusonii, Escherichia A5UFN4, Q4QPH7, coli, Escherichia coli, Haemophilus P44494, Q7VN43, influenzae, Haemophilus influenzae, Q0I463, B5Y334, Haemophilus influenzae, A6TH85, B4F203, Haemophilus influenzae, A4VQP2, B0KKZ7, Haemophilus ducreyi, Haemophilus C3KDW1, Q1I447, somnus, Klebsiella pneumoniae, B1JAD6, B7V209, Klebsiella pneumoniae, Proteus Q9HUL8, Q02F72, mirabilis, Pseudomonas stutzeri, Q88DD1, Q87VJ2, Pseudomonas putida, Pseudomonas A6VD59, B9DPC0, fluorescens, Pseudomonas Q49X89, Q6GHD9, entomophila, Pseudomonas putida, P65492, P65491, Pseudomonas aeruginosa, A7X1T8, A6U1B5, Pseudomonas aeruginosa, Q8NWX9, Q6G9R7, Pseudomonas aeruginosa, A8Z1W7, Q5HGD5, Pseudomonas putida, Pseudomonas A6QGJ5, Q93T05, syringae, Pseudomonas aeruginosa, Q2FHE2, Q8CPE9, Staphylococcus carnosus, Q5HPP4 Staphylococcus saprophyticus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 564 GFRGEALSS Eubacterium rectale C4ZA52 P54278 565 GFVMGEGAAVLV Streptomyces coelicolor P23155 Q9NWU1 LE 566 GFYSAFMVA Bacteroides thetaiotaomicron Q8A9B8 Q12931 567 GGADRIELCS Rhizobium meliloti Q925Z1 Q9NTM9 568 GGAGVQHIAL Streptomyces avermitilis, Q53586, Q9S2F4 P32754 Streptomyces coelicolor 569 GGAGYIGSH Lactobacillus helveticus, Q7WTB1, P96995, Q14376 Streptococcus mutans, Streptococcus P21977 thermophilus 570 GGAGYIGSHT Rhizobium leguminosarum, Q59745, P26503 Q14376 Rhizobium meliloti 571 GGAGYIGSHTV Lactobacillus casei O84903 Q14376 572 GGAIALGHP Bacillus subtilis, Clostridium P45855, P45359, Q9BWD1 acetobutylicum, Escherichia coli, Q46939, Q9I2A8, Pseudomonas aeruginosa, P28790, Q87ZB3, Pseudomonas fragi, Pseudomonas Q3K9D9, Q4ZRA1, syringae, Pseudomonas fluorescens, Q4KFC3, Q48GW4, Pseudomonas syringae, Q02PH7, A6V383, Pseudomonas fluorescens, Q9HZJ3, A5W6G9, Pseudomonas savastanoi, Q93Q11, Q9R9W0, Pseudomonas aeruginosa, Q88L01, Q1I7D5, Pseudomonas aeruginosa, A4XSM9, A4VKA4 Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas oleovorans, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas mendocina, Pseudomonas stutzeri 573 GGAIALGHPLG Acinetobacter baumannii, A3M1H9, B7I3P0, Q9BWD1 Acinetobacter baumannii, B0VLX5, B0VE46, Acinetobacter baumannii, B7H1I1, B2I2J8, Acinetobacter baumannii, Q6FF69, A0KEL0, Acinetobacter baumannii, A4STF3, O32177, Acinetobacter baumannii, A8ACZ3, A4WFX5, Acinetobacter baylyi, Aeromonas Q9F0Y6, P0C7L3, hydrophila, Aeromonas salmonicida, P0C7L2, B7LTZ0, Bacillus subtilis, Citrobacter koseri, Q8X8J4, A1A132, Enterobacter sp., Enterobacter A8A6V0, A7ZU50, cloacae, Escherichia coli, Escherichia Q1R467, Q8FBI3, coli, Escherichia fergusonii, P21151, Q0TAL1, Escherichia coli, Escherichia coli, A6TGM3, Q9I6R0, Escherichia coli, Escherichia coli, Q51956 Escherichia coli, Escherichia coli, Escherichia coli, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Pseudomonas putida 574 GGAIALGHPLGAS Pseudomonas knackmussii Q8VPF1 Q9BWD1 G 575 GGARGQATDI Clostridium thermocellum, Clostridium A3DJ10, B8I8F5 Q16740 cellulolyticum 576 GGDGTLLYA Bacillus licheniformis, Bacillus cereus, Q65LA2, Q81GJ9, O95544 Bacillus thuringiensis, Bacillus cereus, Q6HLY2, Q63EG5, Bacillus anthracis, Bacillus cereus, Q81TQ3, Q73BU7, Bacillus subtilis O31612 577 GGENIYPAE Bacillus licheniformis, Bacillus Q65FT5, A8FGK6, Q96CM8 pumilus, Bacillus subtilis, Bacillus P23971, A7Z809 methylotrophicus 578 GGFGLCGIPE Bacillus subtilis P42315 P55809 579 GGGCSGFQY Aeromonas salmonicida, Aeromonas A4SJ82, A0KNY6, Q86U28 hydrophila, Citrobacter koseri, A8ALD2, C5BAP7, Edwardsiella ictaluri, Enterobacter A4W6Q3, B7LWB7, sp., Escherichia fergusonii, Q1RG32, B1LGV9, Escherichia coli, Escherichia coli, B6HZD2, B7N825, Escherichia coli, Escherichia coli, P0ACC3, B1IQI4, Escherichia coli, Escherichia coli, P0ACC4, A1A7K2, Escherichia coli, Escherichia coli, A7ZWA4, Q0TLH5, Escherichia coli, Escherichia coli, B1XD26, B7M197, Escherichia coli, Escherichia coli, C4ZRP9, B7NIB9, Escherichia coli, Escherichia coli, B7MP18, B5Z0D6, Escherichia coli, Escherichia coli, P0ACC5, B7MBD9, Escherichia coli, Escherichia coli, B7LGL8, B7UIK3, Escherichia coli, Escherichia coli, A7ZHP8, Q0I3N9, Escherichia coli, Haemophilus P45344, A5UBF7, somnus, Haemophilus influenzae, A5UFF5, Q4QJM4, Haemophilus influenzae, Q9X4A0, B8F870, Haemophilus influenzae, A6T4W0, B5Y1L3, Haemophilus influenzae, Q7DDN1, A1KSG6, Haemophilus ducreyi, Haemophilus A1IQG0, Q5F6W8, parasuis, Klebsiella pneumoniae, B4EUE2, Q88QQ5, Klebsiella pneumoniae, Neisseria Q4K514, Q1IFY7, meningitidis, Neisseria meningitidis, Q4ZMM4, Q889Z2, Neisseria meningitidis, Neisseria Q48NN6, Q3K5W6, gonorrhoeae, Proteus mirabilis, C3K2Z6, A4XZB1, Pseudomonas putida, Pseudomonas A4VHK9, B7V623, fluorescens, Pseudomonas Q02TA1, Q9I5Q6, entomophila, Pseudomonas syringae, A6UZG6, B2UFK5, Pseudomonas syringae, Q8Y242 Pseudomonas savastanoi, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas mendocina, Pseudomonas stutzeri, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Ralstonia pickettii, Ralstonia solanacearum 580 GGGSIRIHNA Staphylococcus carnosus B9DNF8 Q6PI48 581 GGIDILVNNAS Rhizobium loti Q988B7 Q6YN16 582 GGILDDLIV Streptomyces coelicolor, O86567, Q82JI2 P48728 Streptomyces avermitilis 583 GGKPANFLD Campylobacter fetus, Haemophilus A0RPE8, A5UCR4, Q96I99 influenzae, Haemophilus influenzae, P45101, A5UIW0, Haemophilus influenzae, Q4QLA3, Q4KFY6, Haemophilus influenzae, Q883Z4, Q4ZUW7, Pseudomonas fluorescens, Q48K68, Q3KFU6, Pseudomonas syringae, C3K6N0, P53593, Pseudomonas syringae, B7UVD3, A6V7K5, Pseudomonas savastanoi, Q02K73, B1JAV3, Pseudomonas fluorescens, Q1I7L3, Q88FB2, Pseudomonas fluorescens, A5W114, B0KNW8 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 584 GGLRTALYNY Campylobacter curvus, A7H0G1, A7ZFB9 Q5JPH6 Campylobacter concisus 585 GGLYPVSAVL Staphylococcus aureus, Q6GCU1, Q5HJI8, P04181 Staphylococcus aureus, Q8NYM5, P60296, Staphylococcus aureus, P60295, Q6GKC1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 586 GGNGWLLDG Desulfovibrio maeticus C4XPE9 Q9HC57 587 GGPPCQGFS Haemophilus parahaemolyticus P50192 P26358 588 GGREHTLAWK Bacillus subtilis P12039 P22102 589 GGRYDGLVG Acinetobacter baumannii, A3M212, B2I3E6 P12081 Acinetobacter baumannii 590 GGSAVDAAI Bacillus anthracis Q51693 A6NGU5 591 GGSDLGPLMV Acinetobacter baylyi Q59088 P06744 592 GGSDLGPLMVT Acinetobacter lwoffii Q9RMC1 P06744 593 GGSDNHLIL Helicobacter hepaticus Q7VFL1 P34896 594 GGSNGGLLV Aeromonas hydrophila Q06903 P48147 595 GGSPTPFDRN Bacteroides thetaiotaomicron Q8A2E9 P08237 596 GGSRGIGRA Escherichia coli P52037 Q8N4T8 597 GGTCVNVGCVP Acinetobacter calcoaceticus, Bacillus Q52109, P16171, P00390 cereus, Enterobacter agglomerans, P94702, P00392, Pseudomonas aeruginosa, P30341 Streptomyces lividans 598 GGTCVNVGCVPK Streptococcus thermophilus Q60151 P00390 KVMW 599 GGTFTISNGGVFG Pseudomonas aeruginosa Q9I3D2 P36957 SL 600 GGTVGDIES Aeromonas hydrophila, Aeromonas A0KGH2, A4SRC2, P17812 salmonicida, Bacillus halodurans, Q9K6D7, Q1WV30, Lactobacillus salivarius, Bacillus Q65DT7, P13242, licheniformis, Bacillus subtilis, Bacillus A7GV88, Q5W343, cytotoxicus, Bacillus clausii, Q88Z76, Q03T27, Lactobacillus plantarum, Lactobacillus Q6HAU5, C1F0R6, brevis, Bacillus thuringiensis, Bacillus A0RLC3, B7IQZ1, cereus, Bacillus thuringiensis, Bacillus Q630R0, B7JHG1, cereus, Bacillus cereus, Bacillus Q814T2, C3P2A0, cereus, Bacillus cereus, Bacillus C3LFL2, Q81JW1, anthracis, Bacillus anthracis, Bacillus Q72XB0, B7HY98, anthracis, Bacillus cereus, Bacillus B9IRX1, B7HFN6, cereus, Bacillus cereus, Bacillus A9VSD6, A7Z9T4, cereus, Bacillus weihenstephanensis, A8FIE5, Q38V48, Bacillus methylotrophicus, Bacillus Q74LG2, Q5FME6, pumilus, Lactobacillus sakei, Q24MK9, Q8G5X7, Lactobacillus johnsonii, Lactobacillus Q5LC42, Q64T27, acidophilus, Desulfitobacterium A8ANY8, A3DGR3, hafniense, Bifidobacterium longum, A6LQF6, Q97F61, Bacteroides fragilis, Bacteroides Q4JVX2, C4LIF4, fragilis, Citrobacter koseri, Clostridium C5B8X3, A4WDW8, thermocellum, Clostridium beijerinckii, Q836G5, B7UHJ6, Clostridium acetobutylicum, Q1R7R3, B1LQB3, Corynebacterium jeikeium, B7LWP4, B7LXJ6, Corynebacterium kropnstedtii, B7N716, B1XDJ0, Edwardsiella ictaluri, Enterobacter B6I6H6, P0A7E7, sp., Enterococcus faecalis, P0A7E5, B1IU61, Escherichia coli, Escherichia coli, P0A7E6, A8A3R5, Escherichia coli, Escherichia B7MLA1, B5Z3E4, fergusonii, Escherichia coli, Q0TE79, C4ZZT3, Escherichia coli, Escherichia coli, B7NV70, A1AEW8, Escherichia coli, Escherichia coli, B7MZ76, B7LEK0, Escherichia coli, Escherichia coli, A7ZQM3, Q74BY3, Escherichia coli, Escherichia coli, Q39W62, B9M9Q5, Escherichia coli, Escherichia coli, A5G5T3, B3EAK5, Escherichia coli, Escherichia coli, A5UD28, A5UIK2, Escherichia coli, Escherichia coli, Q4QLL2, P44341, Escherichia coli, Escherichia coli, Q7VNV5, Q0I200, Escherichia coli, Geobacter B8F5Q9, A6TD54, sulfurreducens, Geobacter B5XV18, Q927T4, metallireducens, Geobacter daltonii, Q71WM0, Q8Y495, Geobacter uraniireducens, Geobacter A1KUX8, Q9JTK1, lovleyi, Haemophilus influenzae, B4RJ40, Q5F7G6, Haemophilus influenzae, Q9JYJ8, A9M0Y3, Haemophilus influenzae, Q6A7X4, B4EUF6, Haemophilus influenzae, C3K6H4, Q4KHF8, Haemophilus ducreyi, Haemophilus B1JBP2, Q3KH94, somnus, Haemophilus parasuis, A5W831, Q88MG1, Klebsiella pneumoniae, Klebsiella Q1I644, B0KSB7, pneumoniae, Listeria innocua, Listeria Q4ZWR0, Q48F77, monocytogenes, Listeria Q886M5, B7V7V1, monocytogenes, Neisseria Q9HXZ4, A6V1F1, meningitidis, Neisseria meningitidis, Q02RA9, A4XWS3, Neisseria gonorrhoeae, Neisseria A4VJT9, Q8Y0B8, gonorrhoeae, Neisseria meningitidis, B2U9C0, A5V8U1, Neisseria meningitidis, C0M8K6, C0MFQ9, Propionibacterium acnes, Proteus Q5M6C03 Q5M1S7, mirabilis, Pseudomonas fluorescens, Q8NZF8, Q1J4X1, Pseudomonas fluorescens, Q1JF16, Q1J9X6, Pseudomonas putida, Pseudomonas P0DD70, Q1JK23, fluorescens, Pseudomonas putida, Q5XA10, P0DD71, Pseudomonas putida, Pseudomonas P65925, Q8DWG1, entomophila, Pseudomonas putida, Q97S93, Q48RF1, Pseudomonas syringae, Q8DQY0, A3CQB0, Pseudomonas savastanoi, A8AZ08, Q8E290, Pseudomonas syringae, Q8E7P8, Q3K3S2 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas stutzeri, Ralstonia solanacearum, Ralstonia pickettii, Sphingomonas wittichii, Streptococcus equi, Streptococcus equi, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus gordonii, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae 601 GHGALAEKA Clostridium novyi A0Q0Q1 Q8TCS8 602 GHGALAEKAL Clostridium acetobutylicum, Q97I45, Q895J3, Q8TCS8 Clostridium tetani, Clostridium A5N848, B9E1K8, kluyveri, Clostridium kluyveri, B8DN07, A1VG88, Desulfovibrio vulgaris, Desulfovibrio Q72ER6 vulgaris, Desulfovibrio vulgaris 603 GHIAFNEPG Lactobacillus delbrueckii, Q047I3, Q1G817, Lactobacillus delbrueckii, A8YTN8, Q74HC4, P46926 Lactobacillus helveticus, Lactobacillus Q5FHT1 johnsonii, Lactobacillus acidophilus 604 GHLRSTIIG Bacillus halodurans Q9KEL8 P54136 605 GHNGAGKST Aeromonas salmon icida Q07698 O94911 606 GHNGAGKTT Pseudomonas stutzeri P19844 Q8IZY2 607 GHPEVYILILP Escherichia coli, Escherichia coli, P0ABI8, P0ABI9, P00395 Escherichia coli, Pseudomonas P0ABJ0, Q9I426, aeruginosa, Pseudomonas putida Q9WWR2 608 GHPSFVMSNSF Streptomyces fradiae P26799 P23526 609 GHSGAGKST Pseudomonas entomophila, Q1IGZ0, Q88RL5 O94911 Pseudomonas putida 610 GHSGAGKSTLL Clostridium acetobutylicum, Q97KD5, Q18C09, O94911 ptoclostridium difficile, Pseudomonas Q4KKK8, Q9HT70, fluorescens, Pseudomonas Q02DK6 aeruginosa, Pseudomonas aeruginosa 611 GHSMGGKTAM Haemophilus influenzae Q57427 Q8NFV4 612 GICGSDVHY Escherichia coli P77360 Q00796 613 GICLGHQLL Desulfovibrio maeticus C4XRH8 P27708 614 GIDLGTTNS Helicobacter acinonychis, Q17VY4, Q7VIE3 P38646 Helicobacter hepaticus 615 GIDLGTTNSCV Campylobacter concisus, A7ZEB5, A7GXU4, P38646 Campylobacter curvus, Desulfovibrio C6BSF2, C3K275, salexigens, Pseudomonas Q9WWG9 fluorescens, Pseudomonas savastanoi 616 GIDLGTTNSCVAV Haemophilus parasuis, Haemophilus B8F7S6, A5UF68, P38646 M influenzae, Haemophilus influenzae, P43736, Q4QJW4, Haemophilus influenzae, A5UBQ1 Haemophilus influenzae 617 GIGGSDLGP Propionibacterium acnes, Q6A5X5, B4SRY7, P06744 Stenotrophomonas maltophilia, B2FL71, Q829V7 Stenotrophomonas maltophilia, Streptomyces avermitilis 618 GIGPVPAIS Staphylococcus aureus, Q7A768, Q7A1P9, P42765 Staphylococcus aureus, Q7A2W9, Q9KWK4, Staphylococcus aureus, Q6GJ93, Q6GBR1, Staphylococcus aureus, Q5HIA0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 619 GIIDLKELEAA Enterobacter sp., Escherichia coli, A4WDB1, B6I5A2, Q9Y697 Escherichia coli, Escherichia coli, P0A6B8, B1LNI6, Escherichia coli, Escherichia coli, B7N6B7, B1IWD1, Escherichia coli, Escherichia coli, P0A6B7, B1X1305, Escherichia coli, Escherichia coli, C4ZXA5, Q0TEV5, Escherichia coli, Escherichia coli, A8A336, B7MYG3, Escherichia coli, Escherichia coli, B7M7N3, B7NRH9, Escherichia coli, Escherichia coli, B5Z104, P0A6B9, Escherichia coli, Escherichia coli, B7LDC2, B7MIM0, Escherichia coli, Escherichia coli, A7ZPX4, B7UGX6, Escherichia fergusonii, Klebsiella B7LKA9, B5XNJ7, pneumoniae, Klebsiella pneumoniae A6TCF1 620 GIIVSNHGGRQLD Pseudomonas mendocina A4XYG7 Q9NYQ3 621 GILLYGPPG Bacillus subtilis O34703 P46459 622 GILVQLPLP Bacillus cytotoxicus, Bacillus cereus, A7GSJ9, Q635A3, Q9H903 Bacillus thuringiensis, Bacillus cereus, A0RIH3, C1ERQ4, Bacillus thuringiensis, Bacillus cereus, Q6HDY4, B7JM32, Bacillus cereus, Bacillus cereus, B7HNU4, B9IXH4, Bacillus cereus, Bacillus cereus, B7IXH2, Q73162, Bacillus cereus, Bacillus cereus, B7HB52, Q818R5, Bacillus weihenstephanensis, Bacillus A9VGW3, C3LJV5, anthracis, Bacillus anthracis, Bacillus Q81M50, C3P7W0, anthracis, Enterococcus faecalis, Q836W7, B0KLM9 Pseudomonas putida 623 GILVQLPLPDH Campylobacter jejuni A7H3N3 Q9H903 624 GIMAHIDAGKTTTT Clostridium botulinum B2UYA7 Q969S9 ERIL 625 GIMAHIDAGKTTTT Methylobacterium sp. B0UHX2 Q969S9 ERILYY 626 GINGFGRIGR Bacillus megaterium, Bacillus cereus, P23722, Q4MQ58, O14556 Haemophilus influenzae, Ralstonia P44304, P52694, solanacearum, Streptomyces arenae, E3VWI2, P54226 Streptomyces arenae 627 GINGFGRIGRL Lactobacillus delbrueckii O32755 O14556 628 GINGTVGGS Corynebacterium jeikeium, Q4JXR5, B1VHR9 Q5T7W7 Corynebacterium urealyticum 629 GIPFYVAAP Bacillus weihenstephanensis, Bacillus A9VFD5, Q731R7, Q9BV20 cereus, Desulfovibrio salexigens C6C0F7 630 GIPIAVKDN Akkermansia muciniphila B2UMP4 Q9H0R6 631 GISGAIQHLAGM Bacillus subtilis, Clostridium P94551, P52039 P13804 acetobutylicum 632 GIVGLPNVGKST Bacillus subtilis, Escherichia coli, P37518, P0ABU2, Q9NTK5 Escherichia coli, Haemophilus P0ABU3, P44681, influenzae, Haemophilus ducreyi Q7VMI2 633 GIVHRDIKP Streptomyces coelicolor Q9XA16 Q14164 634 GKAGRNRWLG Desulfovibrio desulfuricans, B8IYH5, C6C188, Q5T653 Desulfovibrio salexigens, B8DN99 Desulfovibrio vulgaris 635 GKAGRNRWLGKR Methylobacterium extorquens, B7L0R4, A9W4Q4 Q5T653 P Methylobacterium extorquens 636 GKGFQGVMKRW Desulfovibrio salexigens C6C185 P09001 637 GKGRPGWHIECS Staphylococcus carnosus, B9DKW3, Q5HRM3, P49589 Staphylococcus epidermidis, Q8CTU1 Staphylococcus epidermidis 638 GKKVAIIGAG Escherichia coli P09832 P31513 639 GKLHTGRSRNDQ Bacillus methylotrophicus, Bacillus A7Z7L9, O34858, P04424 V subtilis, Bacillus cytotoxicus, Bacillus A7GTR4, A9VKE0, weihenstephanensis, Bacillus cereus, B7IK28, Q6HCP8, Bacillus thuringiensis, Bacillus C3L913, Q81KV8, anthracis, Bacillus anthracis, Bacillus C3PB96, Q9K821, anthracis, Bacillus halodurans, Q633G5, Q817C7, Bacillus cereus, Bacillus cereus, B7HRS6, Q72ZA4, Bacillus cereus, Bacillus cereus, B7H6Y4, B7JS05, Bacillus cereus, Bacillus cereus, A0RJM3, Q5WED9, Bacillus thuringiensis, Bacillus clausii, C6BTR8, Q6GIC8, Desulfovibrio salexigens, P63582, P63583, Staphylococcus aureus, A6QFH1, Q5HHC5, Staphylococcus aureus, ASIRD8, A6U067, Staphylococcus aureus, Q2FZU2, A7X0H4, Staphylococcus aureus, Q8NXF3, Q6GAW6, Staphylococcus aureus, Q2YWS5, A8Z066, Staphylococcus aureus, Q2FIB5, Q8CT81, Staphylococcus aureus, Q5HQK1, B9DIU3, Staphylococcus aureus, Q4L4X6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus carnosus, Staphylococcus haemolyticus 640 GKLNDHFPLVVW Rhizobium loti Q983U5 P07954 QTGSGTQ 641 GKLTARERI Bacillus subtilis P54541 P05166 642 GKPDPDIFL Bacillus subtilis O06995 Q08623 643 GKRVDFSGR Campylobacter fetus, Campylobacter A0RQI4, B9KFG8, O14802 lari, Campylobacter jejuni, A8FKR4, A1VYJ5, Campylobacter jejuni, Campylobacter Q5HVY8, Q9PI30, jejuni, Campylobacter jejuni, B2UUV9, Q17VN6, Helicobacter pylori, Helicobacter Q25806, Q1CS68, acinonychis, Helicobacter pylori, Q9ZK23 Helicobacter pylori, Helicobacter pylori 644 GKSTLINTL Helicobacter hepaticus Q7VGJ2 Q9UHD8 645 GKSTLLNIL Pseudomonas aeruginosa, Q9HX79, Q02SA6, Q94911 Pseudomonas aeruginosa, Q4L8L7 Staphylococcus haemolyticus 646 GKSTLMNIL Acinetobacter baylyi, Campylobacter Q6F813, A0RP01, P45844 fetus, Escherichia coli, Escherichia Q0TJH0, Q1RE44, coli, Escherichia coli, Escherichia coli, A1A9B7, P75831, Escherichia coli, Neisseria Q8XED0, Q5MK06, gonorrhoeae, Neisseria gonorrhoeae, Q5F6V6, Q9K0N7, Neisseria meningitidis, Neisseria Q9JVR5, Q91I90, meningitidis, Pseudomonas Q02MI4, Q1I966, aeruginosa, Pseudomonas Q3KE48, Q4KES7, aeruginosa, Pseudomonas Q881Q1, Q88F88, entomophila, Pseudomonas Q1I7I9, Q4K9A4, fluorescens, Pseudomonas Q92NU9 fluorescens, Pseudomonas syringae, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas fluorescens, Rhizobium meliloti 647 GKSTLVNTL Rhizobium loti Q98JM4 Q9UH03 648 GKTALMMAA Pseudomonas aeruginosa Q9HYV6 Q8N8A2 649 GKTLAYLLP Bacillus cereus Q81E85 Q92841 650 GKTLLAQTLA Rhizobium loti Q982V5 O76031 651 GKTNLDEFA Bifidobacterium longum, Q8G768, B3DU32, Q9H0R6 Bifidobacterium longum, B7GTU6 Bifidobacterium longum 652 GKTNLDEFAMG Lactobacillus brevis, Clostridium Q03Q16, B8I601 Q9H0R6 cellulolyticum 653 GKTNLDEFAMGS Lactobacillus sakei, Lactobacillus Q38VC9, B2G8T6, Q9H0R6 reuteri, Lactobacillus reuteri, A5VLG3, Q6A8P5, Propionibacterium acnes, B8J405 Desulfovibrio desulfuricans 654 GKTSIARSIA Clostridium phytofermentans A9KH99 P36776 655 GKVADYIPQLA Rhizobium sp., Rhizobium meliloti C3MD81, Q92PH0 O94925 656 GKWMDGWETRR Ralstonia pickettii, Ralstonia B2UG65, Q8XUB7, Q8N6M5 solanacearum, Rhizobium meliloti Q92VC1 657 GKWMDGWETRR Acinetobacter baumannii, A3MA02, B0VP26, Q8N6M5 KR Acinetobacter baumannii, B0V9T8, B7GV54, Acinetobacter baumannii, B7ICG5, Q6F6Y1, Acinetobacter baumannii, A6V7Y9, Q02JZ8, Acinetobacter baumannii, B7UW33, Q9I3J8 Acinetobacter baylyi, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa 658 GLAAGKGVI Staphylococcus aureus, Q6GI10, Q6GAD9, P22102 Staphylococcus aureus, Q5HH10, Q8NX87, Staphylococcus aureus, P65895, P65896, Staphylococcus aureus, Q5HQ96, Q8CT26 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 659 GLAARDSLRLEAG Corynebacterium aurimucosum C3PHK3 P48728 660 GLFDLKAAGF Methylobacterium sp., Rhizobium B0UKC4, Q92QW2, P22102 meliloti, Rhizobium sp., Rhizobium C3M9F7, Q984K6, loti, Rhizobium leguminosarum, Q1MIW9, B3PV93, Rhizobium etli, Rhizobium B5ZX12, Q2KA45 leguminosarum, Rhizobium etli 661 GLFDLKAAGFKDP Methylobacterium nodulans B8IP71 P22102 662 GLIIGKGGA Clostridium thermocellum A3DJH8 P51513 663 GLLGPNGAGK Escherichia coli, Escherichia coli, P0A9V1, P0A9V2, Q8WWZ7 Escherichia coli, Ralstonia P0A9V3, Q8XXY9, solanacearum, Rhizobium meliloti P25885 664 GLLGPNGAGKST Bacillus subtilis, Escherichia coli, P94440, P0A9U1, Q8WWZ7 Rhizobium sp. P55476 665 GLLGPNGAGKSTI Rhizobium etli, Rhizobium sp., Q8KLG1, P72335, Q8WWZ7 Rhizobium loti, Rhizobium meliloti, P23703, O52618, Rhizobium leguminosarum, Q1M7W6, Q8GNH6, Rhizobium meliloti, Rhizobium P08720, P50332 leguminosarum, Rhizobium galegae 666 GLNKNLGFS Lactobacillus plantarum Q88X60 O43252 667 GLNKNLGFSPEDR Staphylococcus haemolyticus, Q4L9E6, Q8CR04, O43252 Staphylococcus epidermidis, Q5HLO2 Staphylococcus epidermidis 668 GLPNVGKST Finegoldia magna B0S3Z4 Q9NTK5 669 GLPSHPQHEL Pseudomonas aeruginosa P55218 P32929 670 GLQGSGKTTT Helicobacter pylori, Helicobacter P56005, Q9ZK62 P61011 pylori 671 GLQVGDVIL Pseudomonas putida, Pseudomonas B1J4D7, B0KV30, Q86UT5 putida, Pseudomonas putida, A5W8F5, Q4KGQ4, Pseudomonas fluorescens, Q48EU9, F6AA62, Pseudomonas savastanoi, A4XSC0 Pseudomonas fulva, Pseudomonas mendocina 672 GLSKLARIV Clostridium thermocellum A3DHH6 P30793 673 GLTAYFGLL Bacillus subtilis O34812 Q14914 674 GLTERFELFV Neisseria meningitidis, Neisseria A1KUN1, Q9JYU6, Q15046 meningitidis, Neisseria meningitidis, Q9JTT7, Q5F6U2, Neisseria gonorrhoeae, Neisseria B4RP57 gonorrhoeae 675 GLTGGIASGKS Bacillus licheniformis, Bacillus Q65G95, Q6HSG2, Q8WVC6 anthracis, Bacillus cereus, Bacillus Q72ZF3, Q6HCU7, thuringiensis, Bacillus subtilis, Bacillus Q34932, Q817G7, cereus, Bacillus cereus, Bacillus Q633L3, Q5WEG9, clausii, Lactobacillus johnsonii, Q74IB6, Q8RHR7, Fusobacterium nucleatum, Geobacter Q39R83, Q74FU2, metallireducens, Geobacter Q6GG18, Q5HF85, sulfurreducens, Staphylococcus Q6G8N8, P63832, aureus, Staphylococcus aureus, P63831, Q2FG49, Staphylococcus aureus, P63830, Q2YTA2, Staphylococcus aureus, Q49Y69, Q3K029, Staphylococcus aureus, Q8DYJ2, Q8E449, Staphylococcus aureus, Q5M575, Q5M0N9 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus thermophilus, Streptococcus thermophilus 676 GLTGGIASGKSSV Bacillus halodurans Q9K857 Q8WVC6 677 GLVNNAGIST Streptomyces exfoliatus P19992 Q02338 678 GMGGAMDLV Clostridium acetobutylicum, P23673, P76459, P55809 Escherichia coli, Haemophilus P44874 influenzae 679 GMGIPSISI Lactobacillus sakei, Listeria Q38X10, A0AJW1, Q16831 welshimeri, Listeria innocua, Listeria Q92AF2, Q8Y644, monocytogenes, Listeria B8DDP6, Q71YG0, monocytogenes, Listeria C1KWF5, A4VWC2, monocytogenes, Listeria A4W2M2 monocytogenes, Streptococcus suis, Streptococcus suis 680 GMNAAVRAV Lactobacillus delbrueckii, P80019, Q88VY1, Q01813 Lactobacillus plantarum, Lactobacillus B3WE64, Q03910, casei, Lactobacillus casei, Q8C568, Q5HNK6 Staphylococcus epidermidis, Staphylococcus epidermidis 681 GMNAAVRAW Streptococcus thermophilus, Q9L9E3, Q03KB7 Q01813 Streptococcus thermophilus 682 GMNAAVRAWR Staphylococcus aureus, P65694, Q5HF75, Q01813 Staphylococcus aureus, A6QHN3, A8Z2L4, Staphylococcus aureus, P65695, Q6G8M8, Staphylococcus aureus, P99165, A5ITM2, Staphylococcus aureus, Q2FXM8, A6U2G5, Staphylococcus aureus, Q2YTE2, Q6GG08, Staphylococcus aureus, Q8DTX6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus mutans 683 GMVITIEPGIY Staphylococcus epidermidis, Q8CNW9, Q5HNJ7, Q9NQH7 Staphylococcus epidermidis, Q6GFZ9, Q2FXL9, Staphylococcus aureus, Q5HF67, Q2FG30, Staphylococcus aureus, Q8NW55, Q4L749, Staphylococcus aureus, Q99TF5, Q6G8L9, Staphylococcus aureus, Q7A552, Q2YTD2 Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 684 GMYSALAGF Pseudomonas syringae, Q882A9, Q48IH8, Q86X67 Pseudomonas savastanoi, Q4ZTN0 Pseudomonas syringae 685 GNLCRCTGY Bacillus subtilis, Escherichia coli, Q32143, Q46801, Q06278 Escherichia coli, Eubacterium barkeri, Q8X6C4, Q0QLF3, Pseudomonas sp. D7REY5 686 GNLNAPTIM Stenotrophomonas maltophilia B2FQ89 Q8NE62 687 GNLNAPTIMIAEK Stenotrophomonas maltophilia B4SHV9 Q8NE62 688 GNNGGDGLV Lactobacillus buchneri F4FTW6 Q8NCVV5 689 GNPRPRVFRL Methylobacterium nodulans B8ID11 Q02127 690 GNPRPRVFRLP Methylobacterium extorquens B7KZJ5 Q02127 691 GNTGIGLAL Bacillus subtilis O05393 P35520 692 GNTVVIKPA Bacillus subtilis P42236 O94788 693 GNWDLVGNNTP Campylobacter jejuni, Haemophilus Q59296, P44390, P04040 influenzae, Pseudomonas O52762, Q49XC1, aeruginosa, Staphylococcus Q9EV50, Q66V81, saprophyticus, Staphylococcus Q8NWV5, Q6G9M4, xylosus, Staphylococcus xylosus, Q5HG86, Q7A5T2, Staphylococcus aureus, Q2FH99, Q99UE2, Staphylococcus aureus, Q2YXT2, Q2FYU7, Staphylococcus aureus, Q9L451, Q6GH72, Staphylococcus aureus, Q9L452 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 694 GPCGPCSEI Clostridium kluyveri, Streptomyces A5N7T5, Q827S4 P49588 avermitilis 695 GPCGPCTEIH Clostridium botulinum, Clostridium B2THN0, A6LSF6, Q5JTZ9 beijerinckii, Clostridium botulinum B2V3W2 696 GPFANIAHG Bacillus pumilus, Bacillus cereus, A8FEC9, B7HP29, P11586 Bacillus cereus, Bacillus cereus, B9IYP4, B7JLG8, Bacillus anthracis, Bacillus anthracis, Q81RE1, C3P858, Bacillus anthracis, Bacillus C3LKJ6, Q6HJK9, thuringiensis, Bacillus cereus, Bacillus Q63C61, C1ES77, cereus, Bacillus thuringiensis, Bacillus A0RD97, Q739F4, cereus, Bacillus cereus, Bacillus B7IUA4, Q81E87, cereus, Lactobacillus casei, B3WEG3, Q038Y4, Lactobacillus casei, Lactobacillus Q5FIU5, Q38X32, acidophilus, Lactobacillus sakei, Q1WTW0, A5VHS9, Lactobacillus salivarius, Lactobacillus B2G5A9, Q88W76, reuteri, Lactobacillus reuteri, B2GF64, Q03S45, Lactobacillus plantarum, Lactobacillus Q043I0, Q74JC1, fermentum, Lactobacillus brevis, Q5FJY2, B0UQF5, Lactobacillus gasseri, Lactobacillus C4ZBG8, Q24ZZ8, johnsonii, Lactobacillus acidophilus, Q8RHF4, B1ZJ88, Methylobacterium sp., Eubacterium B1M0D1, Q5XZD9, rectale, Desulfitobacterium hafniense, B8IBS4, B7L0A5, Fusobacterium nucleatum, A9VZT0, Q83WS0, Methylobacterium populi, A6LAR6, Q8A9S8, Methylobacterium radiotolerans, Q64U80, Q5LD60, Eubacterium acidaminophilum, A6L4P0, A7GZZ0, Methylobacterium nodulans, A8Z6G1, A3DI22, Methylobacterium extorquens, Q07064, Q891R3, Methylobacterium extorquens, A5N5B3, B9DYW1, Methylobacterium extorquens, P13419, Q97EB3, Parabacteroides distasonis, Q189R2, B8I3S9, Bacteroides thetaiotaomicron, A9KNJ5, Q4JVW2, Bacteroides fragilis, Bacteroides Q6NH87, Q834D6, fragilis, Bacteroides vulgatus, B0S0G1, Q7VLW6, Campylobacter curvus, B8DDM6, Q71YD9, Campylobacter concisus, Clostridium C1KWH6, A0AJY2, thermocellum, Clostridium Q92AD2, Q8Y624, cylindrosporum, Clostridium tetani, A1KS57, A9M1J1, Clostridium kluyveri, Clostridium Q9JXY2, B4RP08, kluyveri, Clostridium acidurici, Q5FAG1, Q9JVY8, Clostridium acetobutylicum, Q03FM6, Q7MUZ8, ptoclostridium difficile, Clostridium Q98HQ4, Q92N42, cellulolyticum, Clostridium Q1MDG4, Q2K5P2, phytofermentans, Corynebacterium B3PV59, B5ZYA2, jeikeium, Corynebacterium C3MFQ8, O66164, diphtheriae, Enterococcus faecalis, Q4L776, Q8CNV9, Finegoldia magna, Haemophilus Q5HNH4, B9DN77, ducreyi, Listeria monocytogenes, Q8NW37, Q6G8J5, Listeria monocytogenes, Listeria Q6GFX6, Q5HF42, monocytogenes, Listeria welshimeri, Q2G296, A8Z200, Listeria innocua, Listeria A6QHR5, Q2FG06, monocytogenes, Neisseria Q2YTF6, Q7A535, meningitidis, Neisseria meningitidis, A5ITQ4, Q99TD2, Neisseria meningitidis, Neisseria A7X3G5, A6U2J8, gonorrhoeae, Neisseria gonorrhoeae, Q5X9K7, A2RGS2, Neisseria meningitidis, Pediococcus P0DF93, P0DF92, ntosaceus, Porphyromonas gingivalis, Q1J9F2, Q1JJK1, Rhizobium loti, Rhizobium meliloti, Q1JEK4, Q48QZ2, Rhizobium leguminosarum, Q99XR2, Q8NZ49, Rhizobium etli, Rhizobium etli, A3CL27, Q1J4C03 Rhizobium leguminosarum, B9DS83, Q8E5E3, Rhizobium sp., Sphingomonas Q3K138, Q8DZP5, paucimobilis, Staphylococcus Q59925, C1QEI6, haemolyticus, Staphylococcus B1IC26, C1CKW9, epidermidis, Staphylococcus B2IP03, C1C7J4, epidermidis, Staphylococcus C0MFU5, B4U2T6, carnosus, Staphylococcus aureus, C1CR74, Q97QI2, Staphylococcus aureus, A3CN49, Q8DPL5, Staphylococcus aureus, B8ZJQ0, Q04K90, Staphylococcus aureus, B5E4W4, C0M9N3, Staphylococcus aureus, A4W0G0, A4VU67, Staphylococcus aureus, Q48TE8, P0DF91, Staphylococcus aureus, Q1JLK2, Q99ZI9, Staphylococcus aureus, A2REC4, Q1JBM0, Staphylococcus aureus, P0DF90, Q5XC12, Staphylococcus aureus, Q8P0X5, Q1JGN8, Staphylococcus aureus, Q1J6F7, Q5M083, Staphylococcus aureus, Q5M4U2, Q03L41 Staphylococcus aureus, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus sanguinis, Streptococcus pyogenes, Streptococcus uberis, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus equi, Streptococcus equi, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus equi, Streptococcus suis, Streptococcus suis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus 697 GPFANIAHGN Lactobacillus delbrueckii, Q1GA94, Q04AM0 P11586 Lactobacillus delbrueckii 698 GPGGYVAAI Bacillus subtilis, Pseudomonas P21880, P14218, P09622 fluorescens, Pseudomonas Q9I3D1, Q9I1L9, aeruginosa, Pseudomonas P09063, Q6GAB8, aeruginosa, Pseudomonas putida, P0A0E7, P0A0E8, Staphylococcus aureus, Q6GHY9, P99084, Staphylococcus aureus, Q5HGY8, P0A0E6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 699 GPGGYVAAIKAAQ Pseudomonas putida P31052 P09622 LG 700 GPGTGIAPF Citrobacter koseri, Enterobacter sp., A8ANX1, A4WDW1, Q9UBK8 Escherichia coli, Escherichia coli, Q8FEI7, Q1R7T4, Escherichia coli, Escherichia coli, Q0TEA2, A1AEV0, Escherichia coli, Escherichia coli, A8A3P5, Q8X7U1, Escherichia coli, Escherichia coli, A7ZQK7, B1IU77, Escherichia coli, Klebsiella P38038, A6TD49 pneumoniae 701 GPNGAGKSTI Streptococcus pyogenes, P0COE3, P0COE2 Q8WWZ7 Streptococcus pyogenes 702 GPNGAGKTT Escherichia coli, Escherichia coli, P0A9S7, P0A9S8, Q86UK0 Pseudomonas aeruginosa P21629 703 GPNGSGKSN Lactobacillus plantarum, Bacillus Q88WJ9, P51834, Q8NDV3 subtilis, Fusobacterium nucleatum, Q8REH4, Q24U48, Desulfitobacterium hafniense, B9E1H0 Clostridium kluyveri 704 GPNGSGKST Bacillus halodurans Q9Z9J3 Q03519 705 GPNTGGMGA Clostridium acetobutylicum Q97J90 P22102 706 GPNTGGMGAY Lactobacillus plantarum, Q88U30, Q9RHX4, P22102 Corynebacterium ammoniagenes, Q9PN47, Q5HTL1, Campylobacter jejuni, Campylobacter Q8NMH3, Q8Y6C6, jejuni, Corynebacterium glutamicum, Q92AP4, Q71YQ4, Listeria monocytogenes, Listeria Q986A5, Q8DRM0, innocua, Listeria monocytogenes, Q97T98, Q8P308, Rhizobium loti, Streptococcus Q5XEF0, Q9A1Y7, pneumoniae, Streptococcus P0DD58, P0DD59, pneumoniae, Streptococcus Q9F159 pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus suis 707 GPNTNGSQFFI Staphylococcus aureus, Q6GAX2, Q7A6I1, A0A0B4J2A2 Staphylococcus aureus, Q7A1C0, Q6GID4, Staphylococcus aureus, Q99VD4, Q2FZU9, Staphylococcus aureus, Q2FIC1, Q2YWT2, Staphylococcus aureus, Q5HHD1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 708 GPPGAGKGTQA Desulfitobacterium hafniense, Q250L1, B8G1Y7, P54819 Desulfitobacterium hafniense, B3E851, Q82DM5, Geobacter lovleyi, Streptomyces P43414, B1W3Y6, avermitilis, Streptomyces coelicolor, P49974 Streptomyces griseus, Streptomyces livid ans 709 GPPGCGKTL Rhizobium sp. P55530 Q8NBU5 710 GPPGLGKTT Corynebacterium jeikeium, Q4JVD9, C3PGQ6, Q8WVB6 Corynebacterium aurimucosum, Q839T5, A8AUH0, Enterococcus faecalis, Streptococcus Q5LXQ9, Q03IE9, gordonii, Streptococcus thermophilus, Q5M2B1, Q8DWI4, Streptococcus thermophilus, B9DSU1, Q1JP25, Streptococcus thermophilus, Q1JE69, B5XJ28, Streptococcus mutans, Streptococcus A2RC05, Q1JJ71, uberis, Streptococcus pyogenes, Q1J924, Q5XEE4, Streptococcus pyogenes, Q9A1Y1, Q8P302, Streptococcus pyogenes, P0DF51, Q48VY1, Streptococcus pyogenes, P0DF50, Q8E2D9, Streptococcus pyogenes, Q8E7U6, Q3K3X8, Streptococcus pyogenes, A4VSD3, A4VYM0, Streptococcus pyogenes, C1CPD4, C1CIE0, Streptococcus pyogenes, Q8CVVU7, B1I8Y6, Streptococcus pyogenes, Q04MI9, C1CB34, Streptococcus pyogenes, B5E6T3, ClCC50, Streptococcus pyogenes, C0MC84, A3CK22, Streptococcus pyogenes, B2ISI4, Q97SR6, Streptococcus agalactiae, B4U5F8 Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus suis, Streptococcus suis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus equi, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus equi 711 GPPGLGKTTL Arcobacter butzleri, Bacillus A8EVP9, Q9KDI8, Q8WVB6 halodurans, Helicobacter hepaticus, Q7VIU8, Q49Y79, Staphylococcus saprophyticus, B45T32, B2FRN4 Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 712 GPPGLGKTTLA Acinetobacter baumannii, A3M7W1, B2HWT3, Q8WVB6 Acinetobacter baumannii, B0VDI5, B7GYB5, Acinetobacter baumannii, B0VT89, B7I5A9, Acinetobacter baumannii, Q6F991, A4SJ26, Acinetobacter baumannii, A0KPA2, B2UPI9, Acinetobacter baumannii, B7IIT2, B7HE54, Acinetobacter baylyi, Aeromonas Q817W4, A7GTA2, salmonicida, Aeromonas hydrophila, A9VIP6, A7Z768, Akkermansia muciniphila, Bacillus P61533, B7HQH9, cereus, Bacillus cereus, Bacillus P61528, Q045Q2, cereus, Bacillus cytotoxicus, Bacillus B9IYZ4, Q634C4, weihenstephanensis, Bacillus Q6HDA6, C1ESW4, methylotrophicus, Lactobacillus Q81LG9, C3L6U9, johnsonii, Bacillus cereus, Bacillus C3P9A7, A0RJ26, cereus, Lactobacillus gasseri, Bacillus Q048Y7, Q1G941, cereus, Bacillus cereus, Bacillus O32055, Q5FLX2, thuringiensis, Bacillus cereus, Bacillus Q1WT18, B2G6E8, anthracis, Bacillus anthracis, Bacillus A5VIX2, Q65GP6, anthracis, Bacillus thuringiensis, B3WC56, Q03B17, Lactobacillus delbrueckii, A8YTI2, Q88V03, Lactobacillus delbrueckii, Bacillus Q03R36, Q8RE97, subtilis, Lactobacillus acidophilus, A1A1K3, B7GR18, Lactobacillus salivarius, Lactobacillus Q24UN7, B8FQV5, reuteri, Lactobacillus reuteri, Bacillus Q8G6B7, Q183N8, licheniformis, Lactobacillus casei, A0PZV4, Q0TP13, Lactobacillus casei, Lactobacillus Q8XJ14, Q891Z8, helveticus, Lactobacillus plantarum, Q97GT1, A6LTM7, Lactobacillus brevis, Fusobacterium Q0SRN3, A9KP49, nucleatum, Bifidobacterium A3DBU4, A5N206, adolescentis, Bifidobacterium longum, B9E5Q8, B1IMF3, Desulfitobacterium hafniense, A7GHT8, C1FKG1, Desulfitobacterium hafniense, C3KTD2, A5I6F1, Bifidobacterium longum, A7FY19, B1L0B2, ptoclostridium difficile, Clostridium B2TMZ2, B2V338, novyi, Clostridium perfringens, A5G9Y2, B3E468, Clostridium perfringens, Clostridium B9LZC4, P61532, tetani, Clostridium acetobutylicum, B5EAH3, Q39XN6, Clostridium beijerinckii, Clostridium C6E1S8, Q4QNM6, perfringens, Clostridium P44631, A5UAH8, phytofermentans, Clostridium Q7VKV5, Q011M3, thermocellum, Clostridium kluyveri, Q03YJ6, Q92B12, Clostridium kluyveri, Clostridium Q8Y6Z8, B8DHL6, botulinum, Clostridium botulinum, A0AIY1, Q71ZD8, Clostridium botulinum, Clostridium C1KVH9, Q03ER0, botulinum, Clostridium botulinum, B4ETP8, B1JD70, Clostridium botulinum, Clostridium Q1I6E9, Q4ZWL1, botulinum, Clostridium botulinum, A4XRS1, Q48FC5, Clostridium botulinum, Geobacter Q3K7W0, A6VA05, uraniireducens, Geobacter lovleyi, B0KTJ2, Q02IC9, Geobacter daltonii, Geobacter B7UXW5, Q51426, sulfurreducens, Geobacter Q87Y35, Q88NJ0, bemidjiensis, Geobacter C3JYS7, A5VZU7, metallireducens, Geobacter sp., A4VNA3, Q4K7D9, Haemophilus influenzae, Q98F76 Haemophilus influenzae, Haemophilus influenzae, Haemophilus ducreyi, Haemophilus somnus, Leuconostoc mesenteroides, Listeria innocua, Listeria monocytogenes, Listeria monocytogenes, Listeria welshimeri, Listeria monocytogenes, Listeria monocytogenes, Pediococcus ntosaceus, Proteus mirabilis, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas syringae, Pseudomonas mendocina, Pseudomonas savastanoi, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas stutzeri, Pseudomonas fluorescens, Rhizobium loti 713 GPPGLGKTTLAH Campylobacter concisus, A7ZEM1, A7I1C5, Q8WVB6 Campylobacter hominis, A0RN84, A7GZP9, Campylobacter fetus, Campylobacter B4RLV8, Q5F8L2, curvus, Neisseria gonorrhoeae, A1KU52, Q9JZ86, Neisseria gonorrhoeae, Neisseria A9LZC3, Q9JUB0, meningitidis, Neisseria meningitidis, B2UFL1, Q8Y236 Neisseria meningitidis, Neisseria meningitidis, Ralstonia pickettii, Ralstonia solanacearum 714 GPPGSGKGT Micrococcus luteus, Micrococcus P33107, C5CC42 P27144 luteus 715 GPPGTGKTL Clostridium phytofermentans, A9KIG5, A5W382 Q9Y4W6 Pseudomonas putida 716 GPPGTGKTLLA Bacillus pseudofirmus, P94304, Q6M2F0, Q9Y4W6 Corynebacterium glutamicum, P71377, D4HA34, Haemophilus influenzae, C7N1I1, Q4L3G8 Propionibacterium acnes, Slackia heliotrinireducens, Staphylococcus haemolyticus 717 GPPGTGKTLLAKA Bacillus subtilis, Lactobacillus P37476, Q88Z31, Q9Y4W6 plantarum, Lactobacillus plantarum, C6VKW6, A6LD25, Parabacteroides distasonis, A0PXM8, B8I4B9, Clostridium novyi, Clostridium Q0TTK8, P0AAI3, cellulolyticum, Clostridium Q8X9L0, O32617, perfringens, Escherichia coli, Q9ZM66, P71408, Escherichia coli, Helicobacter felis, Q03Z46, O69076, Helicobacter pylori, Helicobacter P59652, D1BLD0 pylori, Leuconostoc mesenteroides, Streptococcus pneumoniae, Streptococcus pneumoniae, Veillonella parvula 718 GPPGTGKTT Escherichia coli, Escherichia coli, P0AAZ5, P0AAZ4, P35250 Escherichia coli, Haemophilus P0AAZ6, P45262 influenzae 719 GPPGVGKTS Acinetobacter baumannii, Bacillus B7GXS7, A0RJ87, P36776 thuringiensis, Bacillus subtilis, P37945, A7ZEJ3, Campylobacter concisus, Clostridium A6LSV5, B8J198, beijerinckii, Desulfovibrio Q72CE6, P0A9M0, desulfuricans, Desulfovibrio vulgaris, P0A9M1, B5EDX8, Escherichia coli, Escherichia coli, Q39OP7, B3E7K2, Geobacter bemidjiensis, Geobacter P43864, O69177 metallireducens, Geobacter lovleyi, Haemophilus influenzae, Rhizobium meliloti 720 GPPGVGKTSIA Clostridium acetobutylicum, Q97FT9, B1GZQ6 P36776 Uncultured termite 721 GPPHDRRFT Geobacter metallireducens Q39T82 P19525 722 GPQHPAAHGVLR Stenotrophomonas maltophilia B4SJH6 O75306 LV 723 GPRYCPSIE Bacillus halodurans, Bacillus Q9RCA8, A7ZAW0, Q9Y2Z2 methylotrophicus, Bacillus clausii, Q5WAG4, P25812, Bacillus subtilis, Bacillus pumilus, A8FJF9, Q1G7Z5, Lactobacillus delbrueckii, Q047G0, Q38UF0, Lactobacillus delbrueckii, Q88RX6, Q1WVH6, Lactobacillus sakei, Lactobacillus Q03N65, Q24M99, plantarum, Lactobacillus salivarius, B8GOL2, A7GWM5, Lactobacillus brevis, A7ZBK0, Q97CVV3, Desulfitobacterium hafniense, A5N450, A6M3M4, Desulfitobacterium hafniense, Q181S8, Q0TLZ5, Campylobacter curvus, Q8XH31, Q0SPQ4, Campylobacter concisus, Clostridium Q17VU9, Q03D60 acetobutylicum, Clostridium kluyveri, Clostridium beijerinckii, ptoclostridium difficile, Clostridium perfringens, Clostridium perfringens, Clostridium perfringens, Helicobacter acinonychis, Pediococcus ntosaceus 724 GPSGAGKST Clostridium tetani, Haemophilus Q895P5, P45092 Q16774 influenzae 725 GPSGAGKSTF Bacillus subtilis, Bacillus halodurans O34814, Q9KFL0 Q9H172 726 GPSGAGKSTL Clostridium botulinum, Clostridium B2V4B8, B2THS4, Q16774 botulinum, Clostridium beijerinckii, A6LSK4, P31548, Escherichia coli, Escherichia coli, Q8XA06, Q1RGD0 Escherichia coli 727 GPSGAGKSTLL Clostridium perfringens, Clostridium Q0TPL7, Q8XJL9, Q16774 perfringens, Clostridium perfringens, Q0SS84, Q8FL82, Escherichia coli, Escherichia coli Q0TLS2 728 GPSGSGKSS Rhizobium sp. P55453 Q9NP78 729 GPSGSGKST Bacillus subtilis, Rhizobium P54537, Q52815 Q9NRK6 leguminosarum 730 GPTGSGKTLLA Aeromonas hydrophila, Aeromonas A0KJU2, A4SM43, O76031 salmonicida, Citrobacter koseri, A8AK15, A4W7A9, Enterobacter sp., Escherichia B7LME1, Q1RF97, fergusonii, Escherichia coli, B1LJJ5, B6HZP5, Escherichia coli, Escherichia coli, B7N8Z2, B1J010, Escherichia coli, Escherichia coli, P0A6H1, P0A6H2, Escherichia coli, Escherichia coli, Q0TKK3, A1A8A7, Escherichia coli, Escherichia coli, A7ZX96, B1XFM6, Escherichia coli, Escherichia coli, C4ZTJ5, B7M3T1, Escherichia coli, Escherichia coli, B7MQF4, B7NJ56, Escherichia coli, Escherichia coli, B5Z3U5, P0A6H3, Escherichia coli, Escherichia coli, B7L675, B7MD97, Escherichia coli, Escherichia coli, B7UJR1, A7ZIJ6, Escherichia coli, Escherichia coli, Q7VP79, B5YOU1, Haemophilus ducreyi, Klebsiella A6T5I1, B4EU54, pneumoniae, Klebsiella pneumoniae, A5W634, B0KJG7, Proteus mirabilis, Pseudomonas Q88KI9, B1J693, putida, Pseudomonas putida, A4XTZ6, Q87YR7, Pseudomonas putida, Pseudomonas Q4ZVM6, Q9I2U0, putida, Pseudomonas mendocina, A6V718, Q02KU5, Pseudomonas syringae, B7VB75, Q48KY9, Pseudomonas syringae, Q3K9X0, C3JYJ9, Pseudomonas aeruginosa, B2FQR3, B4SLN2 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas savastanoi, Pseudomonas fluorescens, Pseudomonas fluorescens, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 731 GPTGSGKTLLAQ Neisseria meningitidis, Neisseria A9M020, A1KUJ4, O76031 meningitidis, Neisseria meningitidis, Q9JTX8, Q9JYY3 Neisseria meningitidis 732 GPTGSGKTLLAQT Sphingomonas wittichii A5V3U4 O76031 733 GPTGSGKTLLAQT Acinetobacter baylyi, Acinetobacter Q6FEP7, B0V4T7, O76031 LA baumannii, Acinetobacter baumannii, A3M1Y8, B0VKU4, Acinetobacter baumannii, B2I3C2, B7I5E4, Acinetobacter baumannii, B7H092, A8FFV9, Acinetobacter baumannii, Q65GJ4, P50866, Acinetobacter baumannii, Bacillus Q6HD54, Q633X2, pumilus, Bacillus licheniformis, B7HQN2, B9IZ47, Bacillus subtilis, Bacillus thuringiensis, C1ETR8, Q72ZV4, Bacillus cereus, Bacillus cereus, B7JQ65, Q81LB9, Bacillus cereus, Bacillus cereus, C3L704, C3P9F7, Bacillus cereus, Bacillus cereus, A7Z7B2, Q817Q2, Bacillus anthracis, Bacillus anthracis, B7HEA4, B7IIY3, Bacillus anthracis, Bacillus A7GTF1, Q5WEN9, methylotrophicus, Bacillus cereus, Q9K8F4, B0UD19, Bacillus cereus, Bacillus cereus, B7KNT1, A9W5F6, Bacillus cytotoxicus, Bacillus clausii, B1LW29, B8IN27, Bacillus halodurans, B1Z9C8, P44838, Methylobacterium sp., Q0I4F0, Q92C84, Methylobacterium extorquens, Q8Y7K9, C1L2H6, Methylobacterium extorquens, B8DHN7, Q720F3, Methylobacterium radiotolerans, A0AI71, Q8XYP6, Methylobacterium nodulans, B2UFQ3 Methylobacterium populi, Haemophilus influenzae, Haemophilus somnus, Listeria innocua, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria welshimeri, Ralstonia solanacearum, Ralstonia pickettii 734 GPTGSGKTLLAQT Campylobacter jejuni, Staphylococcus Q9PIM0, B9DNC0, O76031 LAK carnosus, Staphylococcus Q8CNY5, Q5HNM9 epidermidis, Staphylococcus epidermidis 735 GQDPYHGPNQA Streptococcus mutans Q8DTV8 P13051 736 GQDVLLFIDNIFRF Clostridium thermocellum A3DIM9 P06576 737 GQEVTLCGW Edwardsiella ictaluri, Pseudomonas C5B957, Q51422, Q6PI48 aeruginosa, Pseudomonas B7UXW9, Q02IC5, aeruginosa, Pseudomonas Q4K7D5, Q88NJ4, aeruginosa, Pseudomonas A5VZU3, B0KTJ6, fluorescens, Pseudomonas putida, Q1I6E5, B1JD74 Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida 738 GQKCSACSR Bacillus thuringiensis, Bacillus cereus, Q6HP91, B9J1L9, P30038 Bacillus cereus, Bacillus anthracis, Q63GS0, C3PBP4, Bacillus cereus, Bacillus cereus, B7HSW8, C1EV77, Bacillus cereus, Bacillus anthracis, B7JM99, C3L546, Bacillus thuringiensis, Bacillus A0R909, Q81ZF8, anthracis, Bacillus A9VRG6, P62028, weihenstephanensis, Bacillus cereus, A7GKJ4, Q81IP0, Bacillus cytotoxicus, Bacillus cereus, B7H4V1, B7IUW8 Bacillus cereus, Bacillus cereus 739 GQMNEPPGAR Clostridium perfringens, Clostridium Q0SQZ5, Q0TNC4, P06576 perfringens, Clostridium perfringens Q8XID4 740 GQRELIIGDRQ Clostridium novyi A0Q2Z6 P25705 741 GQRELIIGDRQTG Clostridium botulinum, Clostridium C3KYJ1, A5HY50, P25705 KT botulinum, Clostridium botulinum, C1FQP3, A7FQH7, Clostridium botulinum, Clostridium B1KSS6, B1IE32, botulinum, Clostridium botulinum, A7G9Q7, B2UZJ8, Clostridium botulinum, Clostridium Q9Z689, B2TJZ8 botulinum, Clostridium acetobutylicum, Clostridium botulinum 742 GRELGLPEE Corynebacterium glutamicum, Q8NSR1, A4QBV0, P49915 Corynebacterium glutamicum, Q4JTG0 Corynebacterium jeikeium 743 GRFVIGGPQGDA Lactobacillus plantarum, Lactobacillus Q88XB8, Q1UVUT4 Q00266 G salivarius 744 GRGERAYDIYSRL Geobacter lovleyi, Ralstonia B3E1Z4, Q8XYP7 Q16740 L solanacearum 745 GRGGAGFPTG Pseudomonas aeruginosa Q9I0J7 P49821 746 GRGQRELIIGDRQ Sphingomonas wittichii A5V3X3 P25705 TGK P25705 747 GRGQRELIIGDRQ Methylobacterium extorquens, A9W2R3, B7KUA4, TGKT Methylobacterium extorquens, Q39Q54 Geobacter metallireducens 748 GRGTSTYDG Bacillus cereus, Bacillus anthracis, B7HDP4, C3L822, P43246 Bacillus anthracis, Bacillus anthracis, Q81WR3, C3P5H5, Bacillus thuringiensis, Bacillus cereus, A0RHE1, B7JJ47, Bacillus cereus, Bacillus thuringiensis, C1ENZ3, Q6HF46, Bacillus cereus, Bacillus cereus, B7HLA3, B9IV59, Bacillus cereus, Bacillus cereus, P61665, Q636Q7, Bacillus licheniformis, Bacillus Q65JE2, A9VS13, weihenstephanensis, Bacillus cereus, B7ITM1, Q81A25, Bacillus cereus, Bacillus pumilus, A8FDH3, Q9KAC0, Bacillus halodurans, Fusobacterium Q8RFK2, Q0TRD6, nucleatum, Clostridium perfringens, Q8XL87, Q0STR4, Clostridium perfringens, Clostridium Q187T6, A3DDI3, perfringens, ptoclostridium difficile, A5I2S2, A7FUL0, Clostridium thermocellum, Clostridium C1FNT9, A7GE45, botulinum, Clostridium botulinum, B1IM68, C3KX35, Clostridium botulinum, Clostridium B1KSA3, A5N8I5, botulinum, Clostridium botulinum, B9E1Z0, A0Q0M6, Clostridium botulinum, Clostridium A6LWJ5, B2TIC3, botulinum, Clostridium kluyveri, B2V1M2, B8J008, Clostridium kluyveri, Clostridium B0S1C1, Q4L5Z9, novyi, Clostridium beijerinckii, Q8CPF0, Q5HPP5, Clostridium botulinum, Clostridium P65494, P0C1S1, botulinum, Desulfovibrio A8Z1W6, Q6G9R8, desulfuricans, Finegoldia magna, P65493, A6QGJ4, Staphylococcus haemolyticus, Q931S8, A5ISH9, Staphylococcus epidermidis, Q5HGD6, A7X1T6, Staphylococcus epidermidis, Q2FYZ9, A6U1B4, Staphylococcus aureus, Q2YXR9, Q6GHE0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 749 GRIDILVNN Escherichia coli, Escherichia coli P37440, Q8XBJ4 Q9Y394 750 GRIVETEAY Rhizobium loti Q98DR6 P29372 751 GRKMSKSLGN Lactobacillus plantarum, Lactobacillus Q88V89, Q039Q9, P26640 casei, Lactobacillus casei, B3WDZ1, Q38XM0 Lactobacillus sakei 752 GRKMSKSLGNV Bacillus licheniformis Q65JV7 P26640 753 GRLDVLVNN Methylobacterium extorquens Q49117 Q96LJ7 754 GRLKTGTPPRI Neisseria meningitidis, Neisseria A9M3R4, A1KRM5, Q9Y2Z2 meningitidis, Neisseria gonorrhoeae, Q5F5Y0, Q9JX41, Neisseria meningitidis, Neisseria Q9K1G0, Q8XU65, meningitidis, Ralstonia solanacearum, B2UGW0 Ralstonia pickettii 755 GRNIIHGSDS Staphylococcus epidermidis, Q5HP76, Q8CSI0 O60361 Staphylococcus epidermidis 756 GRPGWHIECS Lactobacillus plantarum, Lactobacillus Q88YX9, Q03SU6, P49589 brevis, Lactobacillus fermentum, B2GAB5, Q1WSS5, Lactobacillus salivarius, Eubacterium C4Z3N5, Q0TMM4, eligens, Clostridium perfringens, Q0SQC1, Q8XHQ5, Clostridium perfringens, Clostridium B2TIF6, B2UY90, perfringens, Clostridium botulinum, Q890M4, A6LPP1, Clostridium botulinum, Clostridium A5N4M6, B9DY88, tetani, Clostridium beijerinckii, B1IGH6, C1FMX3, Clostridium kluyveri, Clostridium A5I7M8, A7FZ91, kluyveri, Clostridium botulinum, A7GJ96, B1KTA5, Clostridium botulinum, Clostridium C3KVS3, Q18CD5, botulinum, Clostridium botulinum, A9KSM5, Q03ZR0, Clostridium botulinum, Clostridium Q03E41, Q4K9S1, botulinum, Clostridium botulinum, Q4ZVN9, C3JYD3, ptoclostridium difficile, Clostridium Q87YQ2, B0KUU0, phytofermentans, Leuconostoc A5W458, Q48L06, mesenteroides, Pediococcus Q88IU4, Q02KT6, ntosaceus, Pseudomonas Q9I2U7, B7VB84, fluorescens, Pseudomonas syringae, A6V727, Q3KA28, Pseudomonas fluorescens, Q1IBP9, A4VL73, Pseudomonas syringae, B1J805, Q6GJD9, Pseudomonas putida, Pseudomonas A8YZM7, Q5HIE5, putida, Pseudomonas savastanoi, Q2G2M6, A6QEI2, Pseudomonas putida, Pseudomonas Q2FJB0, Q99W73, aeruginosa, Pseudomonas Q932G0, A5IQ83, aeruginosa, Pseudomonas A7WYU7, A6TZ06, aeruginosa, Pseudomonas Q8NXY7, Q6GBV8, aeruginosa, Pseudomonas Q2YSD1, Q49V39, fluorescens, Pseudomonas Q4L3I9, Q8D058, entomophila, Pseudomonas stutzeri, Q97S25, Q8DWA9, Pseudomonas putida, Staphylococcus B4U570, Q5M6F6, aureus, Staphylococcus aureus, Q5M1W6, Q99XZ9, Staphylococcus aureus, Q5X9W5, P0DG33, Staphylococcus aureus, P0DG32, Q48RA7, Staphylococcus aureus, Q8NZD1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus mutans, Streptococcus equi, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 757 GRPGWHIECSA Listeria innocua, Listeria Q92F36, Q8YAB1, P49589 monocytogenes, Listeria C1KYH2, B8DF15, monocytogenes, Listeria Q724H3, A0AF38 monocytogenes, Listeria monocytogenes, Listeria welshimeri 758 GRPGWHIECSAM Acinetobacter baumannii, B0V571, B0VAU1, P49589 Acinetobacter baumannii, B7GWA1, B7IBU3, Acinetobacter baumannii, B2HX34, A3M419, Acinetobacter baumannii, Q6FC71, A8F962, Acinetobacter baumannii, Q5WLT3, Q72BNQ5, Acinetobacter baumannii, A1VDQ5, B8DKL0, Acinetobacter baylyi, Bacillus pumilus, Q30ZH8, B8J052, Bacillus clausii, Desulfovibrio vulgaris, A4W7I4, P21888, Desulfovibrio vulgaris, Desulfovibrio C4ZUX4, B1XGC4, vulgaris, Desulfovibrio alaskensis, Q0TKB5, B1LKE5, Desulfovibrio desulfuricans, B7LJI4, B6I0H1, Enterobacter sp., Escherichia coli, Q1RF08, Q8FK44, Escherichia coli, Escherichia coli, B1IZ75, A1A8J2, Escherichia coli, Escherichia coli, B7M4M9, A7ZXI1, Escherichia fergusonii, Escherichia B7MRI9, B5YPP1, coli, Escherichia coli, Escherichia coli, B7NL20, B7L7F3, Escherichia coli, Escherichia coli, B7ME49, Q8XCT9, Escherichia coli, Escherichia coli, A7ZIT5, B7N980, Escherichia coli, Escherichia coli, B7UKK3, Q747A2, Escherichia coli, Escherichia coli, C6E7P0, B5EEK6, Escherichia coli, Escherichia coli, Q39ZL8, Q7VMA0, Escherichia coli, Escherichia coli, Q4QPG7, A5UFP3, Escherichia coli, Geobacter P43816, Q0I1Q1, sulfurreducens, Geobacter sp., A6T5R2, B5Y0K6, Geobacter bemidjiensis, Geobacter Q5F5D6, Q9JXE6, metallireducens, Haemophilus Q9JWJ3, B4F1M6, ducreyi, Haemophilus influenzae, B2U9P8, Q8Y077, Haemophilus influenzae, Q2KAA8, Q1MJ22, Haemophilus influenzae, B5ZWB3, Q984X8, Haemophilus somnus, Klebsiella B3PUS4, Q92R20 pneumoniae, Klebsiella pneumoniae, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis, Proteus mirabilis, Ralstonia pickettii, Ralstonia solanacearum, Rhizobium etli, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium loti, Rhizobium etli, Rhizobium meliloti 759 GRPGWHIECSAM Bacillus cereus, Bacillus cereus, Q81J59, B7HJ28, P49589 A Bacillus cereus, Bacillus cereus, C1ET19, Q73FB7, Bacillus thuringiensis, Bacillus cereus, Q6HPS8, Q63HB0, Bacillus anthracis, Bacillus anthracis, Q8VV1, C3P9N5, Bacillus cereus, Bacillus anthracis, B7JK97, C3LJ62, Bacillus cereus, Bacillus cereus, B7ISZ9, B9IZH4, Bacillus cereus, Bacillus thuringiensis, B7HQS4, A0R8G1, Corynebacterium jeikeium Q4JXJ2 760 GRSNVGKSS Bacillus halodurans, Bacillus clausii, Q9K8F7, Q5WEP2, Q8N3Z3 Bacillus cytotoxicus, Bacillus A7GTE8, A9VIU3, weihenstephanensis, Bacillus cereus, B7IIY0, Q817Q5, Bacillus cereus, Bacillus cereus, B7HEA1, Q6HD57, Bacillus thuringiensis, Bacillus Q81LC2, Q633X5, anthracis, Bacillus cereus, Bacillus C1ETR5, B9IZ44, cereus, Bacillus cereus, Bacillus B7HQM9, B7JQ62, cereus, Bacillus cereus, Bacillus C3P9F4, Q72ZV7, anthracis, Bacillus cereus, Bacillus A0RJ86, C3L700, thuringiensis, Bacillus anthracis, A7Z7A9, Q65GJ7, Bacillus methylotrophicus, Bacillus Q04B34, Q1GAP7, licheniformis, Lactobacillus P38424, A8FFV6, delbrueckii, Lactobacillus delbrueckii, Q180E5, Q833M8, Bacillus subtilis, Bacillus pumilus, B0S273, A0AJ07, ptoclostridium difficile, Enterococcus Q92BF6, B8DHJ0, faecalis, Finegoldia magna, Listeria Q71ZB0, C1KVK5, welshimeri, Listeria innocua, Listeria Q8Y6X3, Q4L712, monocytogenes, Listeria Q8DUH9, C0MA50, monocytogenes, Listeria C0MEW6, B2IR86, monocytogenes, Listeria C1CSI8, B8ZLT0, monocytogenes, Staphylococcus B1ICY8, B9DU74, haemolyticus, Streptococcus mutans, C1CFF1, A3CMV2, Streptococcus equi, Streptococcus Q8P1C8, P64073, equi, Streptococcus pneumoniae, P64072, C1C8F9, Streptococcus pneumoniae, B5E6L1, Q04JI0, Streptococcus pneumoniae, C1CLR7, Q48U21, Streptococcus pneumoniae, A2RF16, Q1J740, Streptococcus uberis, Streptococcus Q5XCL9, Q9A088, pneumoniae, Streptococcus B5XL04, Q1JHC1, sanguinis, Streptococcus pyogenes, Q1JM76, Q1JC92, Streptococcus pneumoniae, Q03LM9, Q8DZ11, Streptococcus pneumoniae, Q3K0K1, Q8E4L9, Streptococcus pneumoniae, P0DA93, P0DA92, Streptococcus pneumoniae, A8AX68, Q5M053, Streptococcus pneumoniae, Q5M5A9 Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus gordonii, Streptococcus thermophilus, Streptococcus thermophilus 761 GRSNVGKSSL Lactobacillus brevis, Lactobacillus Q03QN8, B2G6R5, Q8N3Z3 reuteri, Lactobacillus reuteri, A5VJ95, B2GBC5, Lactobacillus fermentum, B8J030, Q30ZZ9, Desulfovibrio desulfuricans, A1VDC5, Q72BH2, Desulfovibrio alaskensis, C6E8C5, B5EEM1, Desulfovibrio vulgaris, Desulfovibrio B1MXT9, Q03W10, vulgaris, Geobacter sp., Geobacter Q03F28 bemidjiensis, Leuconostoc citreum, Leuconostoc mesenteroides, Pediococcus ntosaceus 762 GRSNVGKSSLI Lactobacillus plantarum, Lactobacillus Q88VE3, Q1WUI3, Q8N3Z3 salivarius, Desulfitobacterium Q245K9, B8FVH0, hafniense, Desulfitobacterium C6BUE5, B3Q039, hafniense, Desulfovibrio salexigens, C3MF47, Q2KD28, Rhizobium etli, Rhizobium sp., Q98D85, Q1MM59, Rhizobium etli, Rhizobium loti, B5ZN41 Rhizobium leguminosarum, Rhizobium leguminosarum 763 GRVKTLHPA Clostridium novyi, Listeria A0Q1J0, Q71YQ3, P31939 monocytogenes, Listeria Q8Y6C5, C1KW64, monocytogenes, Listeria Q92AP3, A0AJL9, monocytogenes, Listeria innocua, B8DDZ2, Q03E83 Listeria welshimeri, Listeria monocytogenes, Pediococcus ntosaceus 764 GRVKTLHPAVH Clostridium tetani, Staphylococcus Q892X3, Q6GI11, P31939 aureus, Staphylococcus aureus, Q2YX50, P67544, Staphylococcus aureus, A5IRW0, P67543, Staphylococcus aureus, A6U0P1, Q8CT27, Staphylococcus aureus, Q5HQ97, Q2FI05, Staphylococcus aureus, Q5HH11, Q8NX88, Staphylococcus epidermidis, Q6GAE0, Q2FZI6, Staphylococcus epidermidis, A6QFT1, Q4L582, Staphylococcus aureus, B9DQ42 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus carnosus 765 GRVQGVCFR Rhizobium meliloti Q92TK9 P14621 766 GRYREFYQCD Clostridium acetobutylicum Q97FJ7 P12081 767 GSDFIKTSTG ptoclostridium difficile Q18C22 Q9Y315 768 GSIRSPLWRGG Desulfovibrio vulgaris, Desulfovibrio A1VEB5, Q72CH9 Q9BYD3 vulgaris 769 GSLTTPPCSE Klebsiella pneumoniae O52535 P23470 770 GSLTTPPCTE Neisseria gonorrhoeae Q50940 P23280 771 GSPAEKAGL Bacillus subtilis, Neisseria Q34358, Q9K1G9, O14745 meningitidis, Neisseria meningitidis Q9JX32 772 GSSQRFGVP Propionibacterium acnes, Q6A9R8, Q3K4Z1, P23378 Pseudomonas fluorescens, Q1MG62 Rhizobium leguminosarum 773 GSVPHGGFG Streptococcus thermophilus, Q5M067, Q5M458, Q96159 Streptococcus thermophilus, Q03L20, A2RFM5, Streptococcus thermophilus, P0DG29, Q48UH6, Streptococcus pyogenes, Q1JHS6, P67577, Streptococcus pyogenes, P0DG28, P67575, Streptococcus pyogenes, Q1JMN3, Q1JCQ7, Streptococcus pyogenes, Q5XD20, P67574, Streptococcus pyogenes, P67573, Q3K2E5, Streptococcus pyogenes, Q1J7K5, A4W083, Streptococcus pyogenes, A4VTZ1 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus suis, Streptococcus suis 774 GTDVAKEAS Bacillus subtilis O34431 Q01814 775 GTGKTLLAR Bacteroides thetaiotaomicron, Q8A128, Q64NW3, P62195 Bacteroides fragilis, Bacteroides Q5L8L7, Q7MX10, fragilis, Porphyromonas gingivalis, B2RL24 Porphyromonas gingivalis 776 GTIGHVDHG Arcobacter butzleri, Lactobacillus A8EW02, A8YUS2, P49411 helveticus, Lactobacillus johnsonii, Q74JU6, Q042T5, Lactobacillus gasseri, Lactobacillus Q5FKR8, B3WE38, acidophilus, Lactobacillus casei, Q039K9, Q04B37, Lactobacillus casei, Lactobacillus Q1GAQ0, Q88VE0, delbrueckii, Lactobacillus delbrueckii, A7GK18, Q38WR7, Lactobacillus plantarum, Bacillus A9VP75, Q6HPR0, cytotoxicus, Lactobacillus sakei, Q814C4, Q63H92, Bacillus weihenstephanensis, Bacillus B7HJ46, C1ET37, thuringiensis, Bacillus cereus, Bacillus A0R8H8, B7JKB7, cereus, Bacillus cereus, Bacillus C3LJ80, Q81VT2, cereus, Bacillus thuringiensis, Bacillus C3P9Q3, B9IZJ2, cereus, Bacillus anthracis, Bacillus B7HQU2, Q73F98, anthracis, Bacillus anthracis, Bacillus B7IT17, Q1WU83, cereus, Bacillus cereus, Bacillus P33166, B2GBC2, cereus, Bacillus cereus, Lactobacillus A8F982, P33165, salivarius, Bacillus subtilis, Q5L890, Q8A463, Lactobacillus fermentum, Bacillus A6KYK9, A0RQJ3, pumilus, Bacteroides fragilis, A7GZK6, A7ZCN0, Bacteroides fragilis, Bacteroides A7I3U7, B9KFF9, thetaiotaomicron, Bacteroides Q5HVZ7, O69303, vulgatus, Campylobacter fetus, A1VYI6, A7H4R3, Campylobacter curvus, A8FKQ5, B1KSM7, Campylobacter concisus, A5I7K8, A7GJ76, Campylobacter hominis, B1IGF6, A7FZ71, Campylobacter lari, Campylobacter A5N4N1, A0PXT1, jejuni, Campylobacter jejuni, Q877L9, Q0SQQ8, Campylobacter jejuni, Campylobacter Q8XFP8, Q0TMN0, jejuni, Campylobacter jejuni, Q97EH5, A6LPP6, Clostridium botulinum, Clostridium A3DJ00, B81I5N8, botulinum, Clostridium botulinum, Q839G8, A5GAW4, Clostridium botulinum, Clostridium Q748X8, Q39Y08, botulinum, Clostridium kluyveri, B5Z8K3, B2UUW8, Clostridium novyi, Clostridium tetani, P56003, B6JN44, Clostridium perfringens, Clostridium Q17VM8, Q03YI2, perfringens, Clostridium perfringens, B1MY04, Q03F25, Clostridium acetobutylicum, Q2K9N2, Q2K9L8, Clostridium beijerinckii, Clostridium P75022, Q925Y6, thermocellum, Clostridium Q1MIE3, Q981F7, cellulolyticum, Enterococcus faecalis, A5V604, A8YZP5, Geobacter uraniireducens, Geobacter P64029, Q6GBT9, sulfurreducens, Geobacter P99152, Q6GJC0, metallireducens, Helicobacter pylori, P64028, A6QEK0, Helicobacter pylori, Helicobacter Q5HIC7, Q2YSB3, pylori, Helicobacter pylori, A5IQA2, Q2G0N0, Helicobacter acinonychis, A6TZ25, Q2FJ92, Leuconostoc mesenteroides, A7WYX6, Q8CQ81, Leuconostoc citreum, Pediococcus Q5HRK4, B9DKV8, ntosaceus, Rhizobium etli, Rhizobium Q4L3K9 etli, Rhizobium radiobacter, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium loti, Sphingomonas wittichii, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus carnosus, Staphylococcus haemolyticus 777 GTKFDSSLDR Neisseria meningitidis, Neisseria P56989, P0A0W2 Q02790 meningitidis 778 GTPDYLAPE Streptomyces coelicolor P54740 Q96GX5 779 GTPVLDIKPY Pseudomonas aeruginosa Q9RPT0 Q9BU70 780 GTQYRSAIY Corynebacterium diphtheriae Q6NEL2 Q9UJ68 781 GTQYRSAIYP Escherichia coli B6I2D2 Q9UJ68 782 GTSSLRRAAQL Listeria monocytogenes, Listeria B8DHJ2, C1KVK3, P08397 monocytogenes, Listeria Q71ZB2, Q8Y6X5, monocytogenes, Listeria Q92BF8 monocytogenes, Listeria innocua 783 GTSSRSTKL Bacillus subtilis, Enterococcus P18158, O86963, P43304 casseliflavus, Staphylococcus Q8CPE6, Q5HPP0, epidermidis, Staphylococcus Q4L608, Q2YXR5, epidermidis, Staphylococcus Q6GHD4, Q7A105, haemolyticus, Staphylococcus Q6G9R2, Q99UH2, aureus, Staphylococcus aureus, Q7A5V7, Q2FYZ4, Staphylococcus aureus, Q5HGD1, Q2FHD8, Staphylococcus aureus, Q49X94, P35596, Staphylococcus aureus, P0DB21, P0DB20, Staphylococcus aureus, Q8NZX0, Q5XAK0, Staphylococcus aureus, Q99YI8 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 784 GTVGAVALD Escherichia coli P37595 Q7L266 785 GTVTAANSS Bacillus subtilis O07618 P55084 786 GVAHAGWKGT Bacillus subtilis O31726 Q8IV20 787 GVDEAGRGP Acinetobacter baylyi, Bacillus Q6FCT7, A7Z4M6, O75792 methylotrophicus, Fusobacterium Q8RDX3, B8I7T9, nucleatum, Clostridium cellulolyticum, B9M597, Q39RP1, Geobacter daltonii, Geobacter A1KRM4, Q5F5X9, metallireducens, Neisseria Q9K1G1, Q9JX40, meningitidis, Neisseria gonorrhoeae, A9M3R5, B2UBB5, Neisseria meningitidis, Neisseria Q8XZH7 meningitidis, Neisseria meningitidis, Ralstonia pickettii, Ralstonia solanacearum 788 GVENLRVVDASIM Citrobacter koseri A8AJN0 Q8NE62 P 789 GVGERTREGND Neisseria gonorrhoeae, Neisseria Q5F4Z0, B4RJG0 P06576 gonorrhoeae 790 GVGERTREGNDL Clostridium novyi, Clostridium A0Q2Z4, A5N3H7, P06576 Y kluyveri, Clostridium botulinum, A7G909, B1IE34, Clostridium botulinum, Clostridium B1KSS8, C1F0P5, botulinum, Clostridium botulinum, A7FQH9, C3KYJ3, Clostridium botulinum, Clostridium A5HY52, Q9Z687 botulinum, Clostridium botulinum, Clostridium acetobutylicum 791 GVHRVQRVP Desulfitobacterium hafniense, B8FZ76, Q24ML9, Q9UGC7 Desulfitobacterium hafniense, B8I562, C3KYH5, Clostridium cellulolyticum, Clostridium A3DIL4, A7G9P2, botulinum, Clostridium thermocellum, B1IE21, C1F097, Clostridium botulinum, Clostridium A5HY35, A7FQG2, botulinum, Clostridium botulinum, BlKSR1, Q898Y5, Clostridium botulinum, Clostridium A6LQG2, A0Q312, botulinum, Clostridium botulinum, B2TJY5, B2UZI5, Clostridium tetani, Clostridium B0S2B6, Q98G93, beijerinckii, Clostridium novyi, Q92MK5, Q2K3T1, Clostridium botulinum, Clostridium B5ZRR4, Q1MBB2, botulinum, Finegoldia magna, A5V9C3 Rhizobium loti, Rhizobium meliloti, Rhizobium etli, Rhizobium leguminosarum, Rhizobium leguminosarum, Sphingomonas wittichii 792 GVHRVQRVPKTE Fusobacterium nucleatum Q8R5W0 Q9UGC7 793 GVIINTASV Clostridium scindens P19337 Q99714 794 GVKKGDRW Campylobacter jejuni, Campylobacter A1W1D6, Q9PMD2, Q86V21 jejuni, Campylobacter jejuni A8FNJ7 795 GVLGEHGRG Geobacter daltonii B9M8U3 O15269 796 GVLVPGGFG Clostridium perfringens, Clostridium Q0SQX5, Q0TNA4, P17812 perfringens, Clostridium perfringens, Q8XIB3, C6BWN7 Desulfovibrio salexigens 797 GVMLRGSGI Campylobacter jejuni, Campylobacter A7H5S8, A8FNN4, O75306 jejuni, Campylobacter jejuni, A1W1H5, Q5HSL5, Campylobacter jejuni, Campylobacter Q9PM99 jejuni 798 GVPFNIASYAL Clostridium cellulolyticum B8I0T8 P04818 799 GVPIIADGGI Bacillus halodurans Q9KGN8 P20839 800 GWDAFGLPAE Citrobacter koseri, Edwardsiella A8AJG0, C5BGC7, O15031 ictaluri, Enterobacter sp., Escherichia A4W827, A7ZJ31, coli, Escherichia coli, Escherichia coli, B1LL91, Q1RER9, Escherichia coli, Escherichia coli, A1A8R7, B7MFR5, Escherichia coli, Escherichia coli, A7ZXR8, B1IYG6, Escherichia coli, Escherichia coli, B7UKT2, P07813, Escherichia coli, Escherichia coli, C4ZWC9, B7NM01, Escherichia coli, Escherichia Q0TK31, B7LLH1, fergusonii, Escherichia coli, B7M5G9, B7L9I6, Escherichia coli, Escherichia coli, B6I153, Q8FJY9, Escherichia coli, Escherichia coli, B7MRS9, B5YQJ4, Escherichia coli, Escherichia coli, Q8XBN8, B7N9P8, Escherichia coli, Klebsiella A6T6A3, B5XZR2, pneumoniae, Klebsiella pneumoniae, B4EV14 Proteus mirabilis 801 GWDCHGLPVE Propionibacterium acnes, Q6AB89, Q9S2X5, P41252 Streptomyces coelicolor, Q82AC9 Streptomyces avermitilis 802 GWKEIEYEV Eubacterium rectale, Clostridium C4ZEK2, Q8XHB3, P31327 perfringens, Clostridium perfringens, Q0SPY4, Q0TM79, Clostridium perfringens, Clostridium A7GE89, C1FNY3, botulinum, Clostridium botulinum, B1KT07, B2UX86, Clostridium botulinum, Clostridium B2THH3, A9KI94 botulinum, Clostridium botulinum, Clostridium phytofermentans 803 GWKKNGWKT Rhizobium loti, Rhizobium Q985W1, Q1MKH6 O60930 leguminosarum 804 GWKKNGWKTS Rhizobium etli Q2KBL2 O60930 805 GWLHTGDIG Bacillus cereus Q72YK9 Q9ULC5 806 GWYMGTEIG Bacillus subtilis O34453 P29475 807 GYEEAAAQG Clostridium thermocellum, A3DHY7, A1VD34, Q9Y2Z2 Desulfovibrio vulgaris, Desulfovibrio Q72B11 vulgaris 808 GYGGPHAAFFA Pseudomonas aeruginosa Q9HTX7 P23378 809 GYGIRYEYG Haemophilus influenzae P45180 P06737 810 GYLGAGKTTLLN Bacillus subtilis P94400 Q5RIA9 811 GYLHIGHAK Citrobacter koseri, Clostridium A8AJD6, A5N6Y3, P07814 kluyveri, ptoclostridium difficile, Q188C8, Q8XMP3, Clostridium perfringens, Clostridium Q0SVB1, Q0TTG1, perfringens, Clostridium perfringens, C5BGA4, A4W846, Edwardsiella ictaluri, Enterobacter B7NMN1, B6HYN9, sp., Escherichia coli, Escherichia coli, P00962, B1IY48, Escherichia coli, Escherichia coli, B1X6L3, A7ZXU0, Escherichia coli, Escherichia coli, C4ZWF6, B7M5J8, Escherichia coli, Escherichia coli, B7L9L7, A7ZJ63, Escherichia coli, Escherichia coli, B7LKT3, B1LLC4, Escherichia fergusonii, Escherichia B7N9S6, Q1REN7, coli, Escherichia coli, Escherichia coli, Q8FJW4, Q0TK03, Escherichia coli, Escherichia coli, A1A8U7, B7MPI5, Escherichia coli, Escherichia coli, B7MFU7, B7UKW1, Escherichia coli, Escherichia coli, B5YQM4, Q8X9H8, Escherichia coli, Escherichia coli, Q7VLM3, Q40K64, Haemophilus ducreyi, Haemophilus P43831, B5XZG7, influenzae, Haemophilus influenzae, A6T6C3, Q5F7G0, Klebsiella pneumoniae, Klebsiella P57000, P56927, pneumoniae, Neisseria gonorrhoeae, B4EV71, Q9I2U8, Neisseria meningitidis, Neisseria Q02KT5, B7VB85, meningitidis, Proteus mirabilis, A4XVG2, Q87YQ1, Pseudomonas aeruginosa, Q88IU5, A4VL72, Pseudomonas aeruginosa, Q8Y199, B2U846 Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas syringae, Pseudomonas putida, Pseudomonas stutzeri, Ralstonia solanacearum, Ralstonia pickettii 812 GYLSDRFGR Bacillus subtilis O31762 Q9Y694 813 GYSVFAGVGERT Aeromonas hydrophila, Aeromonas A0KQX8, A4STP3, P06576 REGND salmonicida, Citrobacter koseri, A8ACN6, C5BF40, Edwardsiella ictaluri, Enterobacter A4WGF5, A8A6J5, sp., Escherichia coli, Escherichia coli, B1IX06, B7UMJ7, Escherichia coli, Escherichia coli, P0ABB4, B7LK77, Escherichia fergusonii, Escherichia B1LL59, A1AHR4, coli, Escherichia coli, Escherichia coli, B1X9W0, C4ZZ10, Escherichia coli, Escherichia coli, B7NR34, B7NF48, Escherichia coli, Escherichia coli, B5YXD6, B7M588, Escherichia coli, Escherichia coli, Q1R4K2, B6I3W9, Escherichia coli, Escherichia coli, B7N2H1, Q0TAX7, Escherichia coli, Escherichia coli, P0ABB5, P0ABB6, Escherichia coli, Escherichia coli, B7MGF2, B7L882, Escherichia coli, Escherichia coli, A7ZTU4, B8F774, Haemophilus parasuis, Haemophilus Q0I5X3, Q7VPP0, somnus, Haemophilus ducreyi, A5UA11, Q40N64, Haemophilus influenzae, P43715, A5UGY9, Haemophilus influenzae, B5XZM4, A6TG36, Haemophilus influenzae, B4F0E7, C3K1E6, Haemophilus influenzae, Klebsiella B1JFU1, Q4ZL24, pneumoniae, Klebsiella pneumoniae, Q87TT4, Q48BG5, Proteus mirabilis, Pseudomonas A4VS62, B0KRA8, fluorescens, Pseudomonas putida, Q3K441, A5WBA3, Pseudomonas syringae, Q88BX4, Q02DF4, Pseudomonas syringae, A6VF32, Q9HT20, Pseudomonas savastanoi, B7V791, Q4K3A9, Pseudomonas stutzeri, Pseudomonas Q1I2I7, A4Y187 putida, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas mendocina 814 GYSVFAGVGERT Helicobacter pylori, Helicobacter Q9ZK81, B6JMX2, P06576 REGNDLY pylori, Helicobacter pylori, B5Z8D0, P55988, Helicobacter pylori, Helicobacter Q1CSD5, Q17Y78 pylori, Helicobacter acinonychis 815 GYSVFAGVGERT Helicobacter hepaticus Q7VJ21 P06576 REGNDLYHEM 816 GYTGEDGVE Neisseria meningitidis, Neisseria Q9K0L8, Q9JVP2 P48728 meningitidis 817 GYTKDYPVE Bacillus subtilis P45867 P45954 818 HARGPVGLEGL Pseudomonas fluorescens, Q4K5F9, A4VR07, P54886 Pseudomonas stutzeri, Pseudomonas B7V8A7, C3K2M9, aeruginosa, Pseudomonas Q02SH4, Q9HX20, fluorescens, Pseudomonas A6V0A3, A4XYY4, aeruginosa, Pseudomonas Q1I4F0, B1J133, aeruginosa, Pseudomonas Q4ZN73, A5W9J6, aeruginosa, Pseudomonas Q87W6, Q88DL4, mendocina, Pseudomonas B0KJY5, Q48DL4, entomophila, Pseudomonas putida, Q8XVT6, B2UC98 Pseudomonas syringae, Pseudomonas putida, Pseudomonas syringae, Pseudomonas putida, Pseudomonas putida, Pseudomonas savastanoi, Ralstonia solanacearum, Ralstonia pickettii 819 HDGPPYANG Campylobacter fetus A0RNK3 Q9NSE4 820 HDLGHGPFSH Bacillus subtilis P39651 Q9Y3Z3 821 HEIGHTLGL Proteus mirabilis, Pseudomonas Q11137, Q9H239 panacis, Pseudomonas aeruginosa A0A0C5CJR8, Q03023 822 HEWEKHGTC Aeromonas hydrophila Q07465 O00584 823 HFDRERIPERVVH Bacillus subtilis P94377 P04040 A 824 HFPLVVWQTGSG Bacillus cereus, Bacillus anthracis, Q81F85, Q81SA0, P07954 TQ Listeria monocytogenes, Listeria Q71XE0, Q929E8, innocua, Listeria monocytogenes, Q8Y551, Q92PB6, Rhizobium meliloti, Staphylococcus Q6GFK5, Q5HE54, aureus, Staphylococcus aureus, Q49YP8, Q4L7F5, Staphylococcus saprophyticus, Q8NW1, Q6G884, Staphylococcus haemolyticus, P64173, P64172 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 825 HFPLVVWQTGSG Pseudomonas aeruginosa Q9I587 P07954 TQTNMNVNEVI 826 HFTSPIRRY Escherichia coli, Haemophilus P21499, P44907 Q8TF46 influenzae 827 HGALYHSQS Bacillus subtilis P37941 P21953 828 HGATGKGNDQ Rhizobium leguminosarum Q1MEZ8 P00966 829 HGDGYPFDG Tannerella forsythia D0EM77 P14780 830 HGIPFYVAAP Desulfitobacterium hafniense, B8FRM1, Q24UA0, Q9BV20 Desulfitobacterium hafniense, A8ANI3, Q317L9, Citrobacter koseri, Desulfovibrio A4W7Z1, B3E3M5 alaskensis, Enterobacter sp., Geobacter lovleyi 831 HGSDSVESA Enterobacter sp., Escherichia coli, A4W096, B7MYF2, Q13232 Escherichia coli, Escherichia coli, B7UGW4, B6I590, Escherichia coli, Escherichia P0A764, B7LKC0, fergusonii, Escherichia coli, B7M7M2, A8A324, Escherichia coli, Escherichia coli, P0A763, B1IWE3, Escherichia coli, Escherichia coli, B7N6A6, B7LDB0, Escherichia coli, Escherichia coli, C4ZX93, B5Z0Y7, Escherichia coli, Escherichia coli, B1XAZ3, A7ZPW1, Escherichia coli, Escherichia coli, Q8FF53, Q1R8L4, Escherichia coli, Escherichia coli, B7MI03, B1LNH3, Escherichia coli, Escherichia coli, Q0TEW7, A1AE56, Escherichia coli, Escherichia coli, B7NRG8, B5XNL1, Klebsiella pneumoniae, Klebsiella A6TCD7 pneumoniae 832 HGSTYGGNPL Campylobacter jejuni, Escherichia Q9PIR7, Q8X4S6, P04181 coli, Escherichia coli, Escherichia coli, P59317, P18335, Rhizobium meliloti Q92SA0 833 HGTAPDIAG Streptococcus mutans Q59940 P50213 834 HHPEWFNVY Rhizobium leguminosarum, Q1MAM8, B5ZTF5, P61457 Rhizobium leguminosarum, Q2K3A7 Rhizobium etli 835 HHPEWFNVYNKV Rhizobium sp., Rhizobium meliloti C3MAI8, Q92L66 P61457 836 HHTFFEMLG Bacillus halodurans, Bacillus Q9KDE6, Q65GS5, P49588 licheniformis, Bacillus subtilis, O34526, Q38YN9, Lactobacillus sakei, Bacillus A7GT67, Q817Z0, cytotoxicus, Bacillus cereus, Bacillus P61697, A8FFM9, cereus, Bacillus pumilus, Bacillus Q634F6, A0RJ00, cereus, Bacillus thuringiensis, Bacillus A9VI09, Q81LK0, weihenstephanensis, Bacillus Q6HDD7, Q5WHM8, anthracis, Bacillus thuringiensis, A7Z735, Q24UT2, Bacillus clausii, Bacillus Q8RFJ8, Q30YS5, methylotrophicus, Desulfitobacterium A1VEQ6, P61700, hafniense, Fusobacterium nucleatum, P43815, Q92BK9, Desulfovibrio alaskensis, Q71ZG6, A0AIV3, Desulfovibrio vulgaris, Desulfovibrio Q8Y722, Q49Y56, vulgaris, Haemophilus influenzae, P67011, P67010, Listeria innocua, Listeria A5ITE3, A7X328, monocytogenes, Listeria welshimeri, A6U287, Q8NW87, Listeria monocytogenes, Q6G8V1, Q2YT60, Staphylococcus saprophyticus, A8Z4F6, A6QHF9, Staphylococcus aureus, Q2FXV9, Q5HFE4, Staphylococcus aureus, Q2FGA8, Q6GG85, Staphylococcus aureus, Q8CSA7, Q5HNT2, Staphylococcus aureus, Q4L6W5 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus 837 HIDMDAFYA Acinetobacter baylyi, Bacteroides Q6FFG4, Q64X95, Q9UBT6 fragilis, Clostridium perfringens, Q8XK37, Q0SSQ2, Clostridium perfringens, Q18A91, Q0TQ38, ptoclostridium difficile, Clostridium Q71Y46, Q8Y5T0, perfringens, Listeria monocytogenes, C1KWR9, Q92A40, Listeria monocytogenes, Listeria B8DBV7, A0AK80, monocytogenes, Listeria innocua, Q9JY58, A1KUQ3, Listeria monocytogenes, Listeria Q9JRG1, Q5F8N2, welshimeri, Neisseria meningitidis, Q92XH8 Neisseria meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Rhizobium meliloti 838 HKMAEANRA Propionibacterium acnes, Clostridium Q6A6L4, B8I5N6, Q9Y2R9 cellulolyticum, Corynebacterium A4QBG8, Q8NT20, glutamicum, Corynebacterium B1VES9, Q4JT38, glutamicum, Corynebacterium C4LL65, A5GAY4, urealyticum, Corynebacterium B9M6U9, B3E7T1, jeikeium, Corynebacterium B5EFP6, C6E4R1, kropnstedtii, Geobacter B1MW22, Q03ZQ3, uraniireducens, Geobacter daltonii, Q98N60 Geobacter lovleyi, Geobacter bemidjiensis, Geobacter sp., Leuconostoc citreum, Leuconostoc mesenteroides, Rhizobium loti 839 HLGHVFPDGP Lactobacillus plantarum, Desulfovibrio Q88W33, Q72EK2, Q9Y3D2 vulgaris, Listeria monocytogenes, C1KWF8, Q71YF7, Listeria monocytogenes, Listeria Q8Y641, Q92AE9, monocytogenes, Listeria innocua, B8DDP3, A0AJW4, Listeria monocytogenes, Listeria P14930, Q9JWM8, welshimeri, Neisseria gonorrhoeae, Q9K1N8, Q92Y46 Neisseria meningitidis, Neisseria meningitidis, Rhizobium meliloti 840 HLGHVFPDGPGP Bacillus licheniformis Q65ID2 Q9Y3D2 841 HLGHVFPDGPGP Bacillus clausii, Bacillus halodurans, Q5WH73, Q9KCX2, Q9Y3D2 NG Bacillus pumilus A8FEA3 842 HLLGTHDFSAF Bacillus clausii Q5WLN0 Q8NOZ8 843 HMGITAENVA Rhizobium meliloti P50174 Q9BWD1 844 HNERLEFLGD Edwardsiella ictaluri, Enterobacter C5B8Y2, A4WDD8, Q9NRR4 sp., Escherichia fergusonii, B7LUZ7, B7N6F5, Escherichia coli, Escherichia coli, Q1R8G6, B1LP80, Escherichia coli, Escherichia coli, A8A377, B6I5E1, Escherichia coli, Escherichia coli, P0A7Y0, B1IVR0, Escherichia coli, Escherichia coli, B1X1341, P0A7Y1, Escherichia coli, Escherichia coli, Q0TES1, A1AE97, Escherichia coli, Escherichia coli, C4ZYJ0, B7NRM0, Escherichia coli, Escherichia coli, B7M810, B7MYJ8, Escherichia coli, Escherichia coli, B5Z141, P0A7Y2, Escherichia coli, Escherichia coli, B7LDG0, A7ZQ11, Escherichia coli, Escherichia coli, B7MIQ2, B7UH07, Escherichia coli, Haemophilus Q4QPN0, A5UBC4, influenzae, Haemophilus influenzae, P44441, A5UFI8, Haemophilus influenzae, A6TCI1, B5XNH0, Haemophilus influenzae, Klebsiella B4F047, Q8Y0I1, pneumoniae, Klebsiella pneumoniae, B2U981 Proteus mirabilis, Ralstonia solanacearum, Ralstonia pickettii 845 HNERLEFLGDA Streptococcus thermophilus, Q5M3S3, Q5LZ68, Q9NRR4 Streptococcus thermophilus, Q03K17 Streptococcus thermophilus 846 HNERLEFLGDAV Desulfovibrio vulgaris, Desulfovibrio Q72C44, B8DPB3, Q9NRR4 vulgaris, Staphylococcus aureus, Q2YXI3, Q931T1, Staphylococcus aureus, A7X1J9, P66669, Staphylococcus aureus, Q6G9Y0, A8Z3R9, Staphylococcus aureus, Q6GHK2, A6QGD3, Staphylococcus aureus, P66668, Q5HGJ9, Staphylococcus aureus, A5ISB8, Q2FZ50, Staphylococcus aureus, A6U152, Q2FHK5, Staphylococcus aureus, Q8CPI1, Q5HPV8, Staphylococcus aureus, Q4L5T5, B9DPJ2, Staphylococcus aureus, Q49X17, A8AWC2, Staphylococcus aureus, Q8E0K7, Q8E680, Staphylococcus aureus, Q3K1Y2, C0MCR4, Staphylococcus aureus, A3CP46, C0M8Y3, Staphylococcus aureus, C10EK4, B2IPN5, Staphylococcus epidermidis, C1C7M6, C1CR56, Staphylococcus epidermidis, Q97QG6, Q8DPJ8, Staphylococcus haemolyticus, B5E4Y2, Q04K72, Staphylococcus carnosus, C1CKY7, B8ZJR8, Staphylococcus saprophyticus, B1IC43, B9DRH1, Streptococcus gordonii, P0DF15, Q1J7V3, Streptococcus agalactiae, Q1JMX4, Q1JCZ9, Streptococcus agalactiae, P66672, P0DF14, Streptococcus agalactiae, P66670, Q48UR6, Streptococcus equi, Streptococcus B5XKB7, A2RFW8, sanguinis, Streptococcus equi, Q5XDA6, Q1JI19, Streptococcus pneumoniae, Q8DT66 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus uberis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans 847 HNPTGIDPT Escherichia coli P00509 P17174 848 HPDIKAISFVGS Bacillus methylotrophicus, Bacillus clausii A7ZAI1, Q5WKZ1 O02252 849 HPDLRRILTDYGF Ralstonia solanacearum, Ralstonia Q8XXQ3, B2U7Q9, O75489 pickettii, Stenotrophomonas B2FNX7, B45QT4 maltophilia, Stenotrophomonas maltophilia 850 HPDLRRILTDYGF Rhizobium meliloti O68854 O75489 EG 851 HPDLRRILTDYGF Rhizobium etli, Rhizobium etli, B3PVZ9, Q2K9T3, Q75489 EGHP Rhizobium leguminosarum, B5ZYL4, Q1MIL3 Rhizobium leguminosarum 852 HPDRNPDDP Desulfovibrio vulgaris, Desulfovibrio A1V9Q3, Q725M6 Q9UB54 vulgaris 853 HPESYHSFM Haemophilus influenzae, Q4QP46, P44538, P46926 Haemophilus influenzae, A5UB10 Haemophilus influenzae 854 HPFPGPGLA Helicobacter pylori B5Z842 P49915 855 HPHRGFETV Pseudomonas aeruginosa, Q9HZ00, Q9I163 O00625 Pseudomonas aeruginosa 856 HPLAGQGVN Escherichia coli, Escherichia coli P75728, P25535 Q9Y2Z9 857 HQTGHNSGVIH Escherichia coli P37339 Q9H9P8 858 HRDIKPENIL Bifidobacterium longum Q8G4G1 Q8IVW4 859 HRDIKPGNIM Bifidobacterium longum Q8G6P9 Q14164 860 HRFAAYFQQG Klebsiella oxytoca P77877 P06744 861 HRGRLNVLA Bacillus subtilis, Bacillus licheniformis, P23129, Q65IH4, Q9ULD0 Bacillus pumilus, Bacillus A8FE66, A7Z5J9 methylotrophicus 862 HRSHIDYLLL Haemophilus somnus, Haemophilus Q0I2G8, A5UHQ2, Q9HCL2 influenzae, Haemophilus influenzae, Q4QMF0, A5UDX7, Haemophilus influenzae, P44857, Q4KHJ1, Haemophilus influenzae, Q48F46, Q3KHC9, Pseudomonas fluorescens, C3K4R1, Q886Q7, Pseudomonas savastanoi, B1JBS6, A4XWX9, Pseudomonas fluorescens, A6V1B5, Q02RE5, Pseudomonas fluorescens, B0KS79, Q9HXW7, Pseudomonas syringae, B7V2U0, Q4ZWU3, Pseudomonas putida, Pseudomonas Q1I610, Q88MQ0, mendocina, Pseudomonas A5W867 aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida 863 HRVQRVPKTE Haemophilus parasuis, Haemophilus B8F526, Q4QKS1, Q9UGC7 influenzae, Haemophilus influenzae, P43917, Q013135, Haemophilus somnus, Haemophilus Q7VMV9, Q888C1 ducreyi, Pseudomonas syringae 864 HTGDSVVVAP Staphylococcus carnosus B9DPN2 P31327 865 HTGRSRNDQV Desulfitobacterium hafniense, Q24ZG7, B8FWX3 P04424 Desulfitobacterium hafniense 866 HTNFSTKAMRE Streptomyces viridochromogenes P19432 P15104 867 HTNGSQFFI Staphylococcus saprophyticus Q49W93 P30414 868 HTVCEEARCPNI Bacillus clausii Q5WDS6 O43766 869 HVRGGGELG Escherichia coli, Rhizobium sp., P24555, P55656, Q4J6C6 Rhizobium sp. P55627 870 HVSTGGGASLE Finegoldia magna B0S1H0 P07205 871 IAAGEVIQRPA Parabacteroides distasonis, A6LEJ8, Q8A120, P40692 Bacteroides thetaiotaomicron, Q5L8M5, Q64NX1, Bacteroides fragilis, Bacteroides A6KXH3, B2RL29, fragilis, Bacteroides vulgatus, Q7MX15 Porphyromonas gingivalis, Porphyromonas gingivalis 872 IAATNRPDVLD Haemophilus influenzae P45219 Q9BVQ7 873 IACGTSYHAG Acinetobacter baylyi, Bacillus Q6F6U8, Q65P46, Q06210 licheniformis, Bacillus cereus, Bacillus Q81J01, Q6HPL2, thuringiensis, Bacillus anthracis, Q81VN5, Q73F49 Bacillus cereus 874 IADVGLVGFPN Clostridium phytofermentans A9KMF5 A4D1E9 875 IAHRLSTIQ Streptococcus pneumoniae P35598 O95342 876 IAHVDHGKSTL Stenotrophomonas maltophilia, B2FQC4, B4SRL3 P13639 Stenotrophomonas maltophilia 877 IAREMNLSE Pseudomonas fluorescens Q51792 P30039 878 IAREMNLSET Pseudomonas chlororaphis Q51520 P30039 879 IATGHYART Geobacter uraniireducens A5GE36 O75648 880 IAVGSDADIV Ralstonia pickettii Q8VTT5 Q14117 881 IAVLTSGGDA Clostridium botulinum, Clostridium B1L266, C3KV06, P08237 botulinum, Clostridium botulinum, A5I798, A7GIW9, Clostridium botulinum, Clostridium C1FM55, B1IFV9, botulinum, Clostridium botulinum, A7FYW7, Q8XNH2, Clostridium botulinum, Clostridium O08308, Q0I267, perfringens, Clostridium B9DN94, A4VTS0, acetobutylicum, Haemophilus A3CM69, B5E3Z8, somnus, Staphylococcus carnosus, B1IB66, C1C6M8, Streptococcus suis, Streptococcus A8AXW1, C1CRZ7, sanguinis, Streptococcus C1CJY4, C1CDP4, pneumoniae, Streptococcus Q97RC6, B8ZNU0, pneumoniae, Streptococcus 62IP53, Q8DQ85, pneumoniae, Streptococcus gordonii, Q04L24, P65696, Streptococcus pneumoniae, P65697, Q3K1E6, Streptococcus pneumoniae, C0M8V6, B4U2M2, Streptococcus pneumoniae, C0MGJ9, P0DD03, Streptococcus pneumoniae, P0DD02, 65XLV6, Streptococcus pneumoniae, A2RE65, Q1JGH6, Streptococcus pneumoniae, Q48T86, Q1JLD9, Streptococcus pneumoniae, Q8P056, Q1J6F7, Streptococcus pneumoniae, Q5X6V2, Q99ZD0, Streptococcus agalactiae, B9DSA4 Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus equi, Streptococcus equi, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus uberis 882 ICPVGALTS Streptomyces coelicolor Q9XAR0 P28331 883 IDGLIVTNTT Acinetobacter baylyi, Acinetobacter Q6FCL9, B7GZW7, Q02127 baumannii, Acinetobacter baumannii, A3M6Y2, 67I2L5, Acinetobacter baumannii, B2HUT6, B0V824, Acinetobacter baumannii, B0VKB8 Acinetobacter baumannii, Acinetobacter baumannii 884 IDLAIDGADEVD Staphylococcus epidermidis, Q8CRC8, Q5HLQ9, P49247 Staphylococcus epidermidis, Q5HDM1, Q6GE99, Staphylococcus aureus, P66696, Q6G6Y5, Staphylococcus aureus, P66694, P66695 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 885 IDLIIPRGS Clostridium thermocellum, Clostridium A3DC22, B8I6T0 P54886 cellulolyticum 886 IDQLKPGGRL Geobacter sulfurreducens Q74CZ5 P22061 887 IDTCQGDSGGP Streptomyces glaucescens Q54179 P10323 888 IDTGMGLER Lactobacillus johnsonii, Lactobacillus P61702, Q045P6, P49588 gasseri, Lactobacillus acidophilus, Q5FLW6, A8YTJ0, Lactobacillus helveticus, Lactobacillus Q03R43, Q1WT32, brevis, Lactobacillus salivarius, Q0TPH4, Q0SS42, Clostridium perfringens, Clostridium Q8XJH6, Q97IG3, perfringens, Clostridium perfringens, Q835J8, Q03ER8 Clostridium acetobutylicum, Enterococcus faecalis, Pediococcus ntosaceus 889 IDTGMGLERLV Lactobacillus casei Q03B02 P49588 890 IDTPGHVDFT Clostridium tetani, Clostridium Q890N8, A9KRZ3, Q96RP9 phytofermentans, Corynebacterium B1VET0 urealyticum 891 IDTPGHVDFTIEVE Campylobacter jejuni, Campylobacter A7H4P5, Q5HVX6, Q96RP9 R jejuni, Campylobacter jejuni, Q9PI16, A8FKR7, Campylobacter jejuni, Campylobacter A0RQI0, A1VYJ8, fetus, Campylobacter jejuni, A7I3T6, B9KFH1, Campylobacter hominis, A8Z6I6, A7GZJ4, Campylobacter lari, Campylobacter Q9ZK24, P56002, concisus, Campylobacter curvus, B2UUV6, Q17VN9, Helicobacter pylori, Helicobacter B5Z8J0, Q1CS71, pylori, Helicobacter pylori, B6JN34, Q7VJ85 Helicobacter acinonychis, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori, Helicobacter hepaticus 892 IDVWEHAYYL Bacillus cereus, Bacillus anthracis Q814I6, Q81JK8 P04179 893 lEAHGTGTK Bacillus subtilis Q9R9J1 P49327 894 IFITHLHGDH Bacillus clausii, Bacillus halodurans Q5WGC3, Q9KC61 Q9H777 895 IFLRELISNASDA Geobacter sulfurreducens P61185 P14625 896 IGGADMPW Escherichia coli, Escherichia coli, P0AB69, P0AB67, Q13423 Escherichia coli, Haemophilus P0AB68, P43010 influenzae 897 IGGDGSLTGA Bacteroides thetaiotaomicron, Q8A624, Q8A8R5 Q01813 Bacteroides thetaiotaomicron 898 IGGGMAYTFLK Bifidobacterium adolescentis, A1A1N3, B1W0Z3, P07205 Streptomyces griseus, Streptomyces Q9Z519, Q829W2 coelicolor, Streptomyces avermitilis 899 IGIAMGSGT Escherichia coli P37617 Q14983 900 IGIGGSDLGP Neisseria meningitidis, Neisseria Q9JSS6, Q5F694, P06744 gonorrhoeae, Neisseria meningitidis Q9K153 901 IGKAGRNRW Streptococcus agalactiae, Q8E2C8, Q8E7T5, Q5T653 Streptococcus agalactiae, Q3K3W6 Streptococcus agalactiae 902 IGKAGRNRWLGK Desulfovibrio maeticus C4XLX6 Q5T653 RP 903 IGKGFQGVMKRW Geobacter uraniireducens A5GAW5 P09001 GFKG 904 IGLAVMGQNLILN Haemophilus ducreyi Q7VMX4 P52209 MND 905 IGLAVMGQNLILN Aggregatibacter P70718, P43774 P52209 MNDHGF actinomycetemcomitans, Haemophilus influenzae 906 IGMPHRGRLN Corynebacterium glutamicum Q8NRC3 Q96HY7 907 IGSGGREHT Bacillus halodurans Q9KF52 P22102 908 IGSGPGGYVAAI Rhizobium etli O05940 P09622 909 IGSPPGYVG Clostridium acetobutylicum Q97KG0 Q9H078 910 IGSPPGYVGHEE Bacillus subtilis O31673 Q9H078 911 IGVLTSGGD Bacillus halodurans, Bacillus clausii, Q9K843, Q5WEF6, Q01813 Bacillus licheniformis, Bacillus Q65G82, A8FG55, pumilus, Bacillus subtilis, Bacillus O34529, Q4MVY3, cereus, Bacillus cereus, Bacillus B9J099, Q6HCT3, thuringiensis, Bacillus cereus, Bacillus Q72ZD8, Q633J8, cereus, Bacillus cereus, Bacillus B7HRN9, C1EUU3, cereus, Bacillus anthracis, Bacillus Q81KZ0, A0RJJ6, thuringiensis, Bacillus cereus, Bacillus B7JRX2, C3L8X8, anthracis, Bacillus anthracis, Bacillus C3PAI8, A7Z7K6, methylotrophicus, Bacillus A9VJR1, B7HFB3, weihenstephanensis, Bacillus cereus, B7IJZ8, Q817F3, Bacillus cereus, Bacillus cereus, A7GTP4, Q9FC99 Bacillus cytotoxicus, Streptomyces coelicolor 912 IGVLTSGGDA Citrobacter koseri, Edwardsiella A8AL13, C5BC26, Q01813 ictaluri, Enterobacter sp., A4WG81, Q9Z6C3, Enterobacter cloacae, Escherichia P0A796, A8A720, coli, Escherichia coli, Escherichia coli, Q0TAE8, B6I4Q8, Escherichia coli, Escherichia coli, B1LNL9, B7N2Q7, Escherichia coli, Escherichia coli, B7NFL3, A7ZUC9, Escherichia coli, Escherichia coli, B1IVG3, B1X1382, Escherichia coli, Escherichia coli, B7NU91, B5YZ53, Escherichia coli, Escherichia coli, B7LA13, C5A083, Escherichia coli, Escherichia coli, B7M6W7, P0A797, Escherichia coli, Escherichia coli, B7MI48, B7LVC9, Escherichia fergusonii, Escherichia Q8FBD0, B7UNN6, coli, Escherichia coli, Klebsiella B5XZ40, A6TGB8 pneumoniae, Klebsiella pneumoniae 913 IHARGPVGLEGL Acinetobacter baylyi, Acinetobacter Q6FEN5, B0VKT1, P54886 baumannii, Acinetobacter baumannii, B2I3D3, B0V4S6, Acinetobacter baumannii, B7H081, B7I5F5, Acinetobacter baumannii, A3M1Z8 Acinetobacter baumannii, Acinetobacter baumannii 914 IHDAVRPFV Rhizobium loti Q98MX9 A4D126 915 IHDAVRPFVE Bifidobacterium longum, B7GMX1, Q8G7E2, A4D126 Bifidobacterium longum, B3DTQ9 Bifidobacterium longum 916 IHGSDSVESA Staphylococcus haemolyticus, Q4L6H1, Q49XS3, Q13232 Staphylococcus saprophyticus, B9DNV3 Staphylococcus carnosus 917 IIEPTSGNTGIGLA Bacillus subtilis, Streptococcus O34476, Q5XAQ3 P35520 pyogenes 918 IIFTSGGTE Bacillus subtilis O34599 Q96I15 919 IIGGGMAFTFLK Geobacter metallireducens, Q39U98, C6E770, P00558 Geobacter sp., Geobacter B5EF40, A5G382, bemidjiensis, Geobacter B9M2C3 uraniireducens, Geobacter daltonii 920 IILDEPTAG Bacillus cereus, Bacillus anthracis Q81CT8, Q81PZ8 Q9BZC7 921 IILLDEATSALD Lactobacillus plantarum Q88YK7 Q9NP58 922 IIPWNFPLLM Pseudomonas fluorescens O06837 O94788 923 IITGPNMGGKST Acinetobacter baumannii, B0VAU7, B2HX50, P43246 Acinetobacter baumannii, B7IBV9, B7GW85, Acinetobacter baumannii, B0VUC9, Q6FC54 Acinetobacter baumannii, Acinetobacter baumannii, Acinetobacter baylyi 924 IITGPNMGGKSTY Aeromonas salmonicida, Aeromonas A4SIL2, A0KPG5, P43246 hydrophila, Citrobacter koseri, A8ANU8, A4WDU5, Enterobacter sp., Escherichia coli, B1LQ55, B7NT79, Escherichia coli, Escherichia coli, B6I6B9, Q8FEL3, Escherichia coli, Escherichia coli, A7ZQH3, B7MYN6, Escherichia coli, Escherichia coli, Q0TEC9, Q1R7W4, Escherichia coli, Escherichia coli, A1AES5, B7MKK5, Escherichia coli, Escherichia B7LWH8, B7N6W4, fergusonii, Escherichia coli, B7LEE7, B7LXE0, Escherichia coli, Escherichia coli, B5Z397, Q9S6P8, Escherichia coli, Escherichia coli, B7UHE9, P23909, Escherichia coli, Escherichia coli, B1IUU6, A8A3L2, Escherichia coli, Escherichia coli, B1XCR0, C4ZZN7, Escherichia coli, Escherichia coli, Q4QML2, A5UE20, Haemophilus influenzae, Q0I1B8, B5XV49, Haemophilus influenzae, A6TD24, B4F220, Haemophilus somnus, Klebsiella Q87XW6, Q1I659, pneumoniae, Klebsiella pneumoniae, A5W816, B1JB25, Proteus mirabilis, Pseudomonas Q88ME7, B0KSD2 syringae, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 925 IlYTSGTTG Bacillus weihenstephanensis, Bacillus A9VM74, B7JDD6, Q4G176 cereus, Bacillus cereus, Bacillus B9J2F2, Q6HC29, thuringiensis, Bacillus cereus, Bacillus B7HTW3, Q81611, cereus, Bacillus anthracis, Bacillus C3LB87, C3PCK3, anthracis, Bacillus anthracis, Bacillus Q81K97, A0RK73, thuringiensis, Bacillus cereus, Bacillus Q63215, A7GU88, cytotoxicus, Bacillus subtilis, P39845, P44446 Haemophilus influenzae 926 IlYTSGTTGRPKGV Bacillus subtilis P27206 Q4G176 927 IKAISFVGS Bacillus subtilis, Bacillus subtilis, A7BJC4, P42412, O02252 Bacillus licheniformis Q65D00 928 IKEGDIVKRTG Clostridium perfringens, Clostridium Q0S0Z3, Q8XID2, P25705 perfringens, Clostridium perfringens, Q0TNC2, Q180W8 ptoclostridium difficile 929 IKKAYRKLA Desulfitobacterium hafniense, Q24SS4, B8FUN3, Q8NHS0 Desulfitobacterium hafniense, Q182E7, Q8NLY8, ptoclostridium difficile, Q82EX7 Corynebacterium glutamicum, Streptomyces avermitilis 930 IKKAYRKMALKYH Campylobacter lari, Campylobacter B9KFK6, Q5HTK3, O75953 PD jejuni, Campylobacter jejuni, A7H2C0, Q85213, Campylobacter jejuni, Campylobacter A8FMW6, A1WOP5, jejuni, Campylobacter jejuni, Q7VG06 Helicobacter hepaticus 931 IKKAYRRKA Propionibacterium acnes Q6A997 P25686 932 IKPGAIVID Listeria innocua, Listeria Q92BZ4, B8DFW8, P11586 monocytogenes, Listeria Q8Y7C5, A0A1G1 monocytogenes, Listeria welshimeri 933 IKPGSMGKP Bacillus subtilis, Bacillus subtilis COSPB0, P39062 Q53FZ2 934 IKVGIGPGS Helicobacter pylori P56088 Q9P2T1 935 IKWNFTKFL Neisseria meningitidis, Neisseria A1KV41, P0A0T4, P36969 meningitidis, Neisseria meningitidis, P0A0T5, P0C2T0 Neisseria meningitidis 936 IKWNFTKFLID Bacillus halodurans Q9Z9N7 P36969 937 ILCFYGPPGVGKT Helicobacter pylori, Helicobacter Q9ZJL3, P55995 P36776 S pylori 938 ILFIDEIHR Helicobacter acinonychis, Q17WP7, B2USM3, Q96S55 Helicobacter pylori, Helicobacter Q9ZM57, B5ZAF5, pylori, Helicobacter pylori, B6JKW4, Q1CUB7, Helicobacter pylori, Helicobacter O25699 pylori, Helicobacter pylori 939 ILFSAHSLP Geobacter metallireducens Q39ZQ5 P22830 940 ILGHVQRGG Streptomyces coelicolor Q9L1L8 Q01813 941 ILGQDPYHG ptoclostridium difficile, Ralstonia Q182G9, Q8XVE4 P13051 solanacearum 942 ILGQDPYHGP Streptococcus pyogenes, B5XL20, Q48U05, P13051 Streptococcus pyogenes, A2RFO0, Q1JHA5, Streptococcus pyogenes, Q1JC76, Q1JM60, Streptococcus pyogenes, Q9A072, Q1J724, Streptococcus pyogenes, B9DSB9, B4U3D4, Streptococcus pyogenes, C0M7J9, Q8P1B6, Streptococcus pyogenes, P0DG75, P0DG74, Streptococcus pyogenes, C0ME57, Q5XCK3 Streptococcus uberis, Streptococcus equi, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus equi, Streptococcus pyogenes 943 ILILDEATS Lactobacillus plantarum, Bacillus Q88XV2, Q81J16, Q2M3G0 cereus, Bacillus cereus, Bacillus Q73F67, Q6HPN0, thuringiensis, Bacillus thuringiensis, A0R8K8, Q81VQ2, Bacillus anthracis, Bacillus cereus, Q63H62, Q03182, Streptococcus thermophilus, Q5M243, Q5LXJ3, Streptococcus thermophilus, Q8DMX9, Q97N50, Streptococcus thermophilus, Q04HV7 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 944 ILITGGAGF Escherichia coli P27830 Q8NBZ7 945 ILVDYSKNL Aeromonas salmonicida, Aeromonas A4STE1, A0KEM2 P06744 hydrophila 946 ILVFDLGGGTFDV Corynebacterium diphtheriae Q6NEY9 P11021 SLL 947 ILVHGDAAF Bacillus cereus, Bacillus cereus, C1ELG5, B7HH19, Q9ULD0 Bacillus cereus, Bacillus cereus, B9IU58, B7I0H2, Bacillus cereus, Bacillus cereus, Q81GF2, B7JEU9, Bacillus anthracis, Bacillus anthracis, Q81TK1, C3LAU3, Bacillus anthracis, Bacillus cereus, C3P487, B7IM94, Bacillus cereus, Bacillus thuringiensis, Q63EB1, Q6HL58, Bacillus cereus, Bacillus cytotoxicus, Q73BN8, A7GMD4, Bacillus weihenstephanensis A9VJX9 948 ILYTSGTTG Bacillus subtilis O07610 Q9H6R3 949 IMIHQPSGGA Bacillus halodurans Q9K888 Q16740 950 IMITPICPHSL Clostridium phytofermentans A9KMB6 Q95544 951 IMVARGDLG Corynebacterium efficiens, Q8FP04, P43924 P30613 Haemophilus influenzae 952 IMVGPGTGIAPF Bacillus subtilis O08336 Q9UBK8 953 IMVGPGTGVAPF Bacillus megaterium P14779 P16435 954 INGFGRIGR Bacillus subtilis, Citrobacter koseri, Q34425, A8APE1, O14556 Edwardsiella ictaluri, Enterobacter C5BAU7, A4WE72, sp., Escherichia coli, Escherichia coli, Q1R7A6, B7MZM0, Escherichia coli, Escherichia coli, B7UHW9, B1LDD2, Escherichia coli, Escherichia coli, B6I761, B7N7H3, Escherichia coli, Escherichia coli, P0A9B6, Q0TDS9, Escherichia coli, Escherichia coli, B1IT76, P0A9B7, Escherichia coli, Escherichia coli, B5YQB9, A8A467, Escherichia coli, Escherichia coli, B1XEL0, C5A0J7, Escherichia coli, Escherichia coli, B7LYU4, P0A9B8, Escherichia coli, Escherichia coli, B7LFI3, A7ZR35, Escherichia fergusonii, Escherichia B7LPD5, B7NHY6, coli, Escherichia coli, Escherichia coli, A1AFB1, B7MMA9, Helicobacter pylori, Helicobacter Q9ZKT0, P55971, pylori, Klebsiella pneumoniae, P24164, A6TDT2, Klebsiella pneumoniae, Klebsiella B5XUB7, B4EUH7, pneumoniae, Proteus mirabilis, P27726, Q59800 Pseudomonas aeruginosa, Streptomyces aureofaciens 955 INGFGRIGRL Clostridium pasteurianum, Clostridium Q59309, O52631, O14556 acetobutylicum, Staphylococcus P0A038, Q6GB58, aureus, Staphylococcus aureus, P0A037, Q5HHP5, Staphylococcus aureus, Q6GIL8, P99136, Staphylococcus aureus, P0A036, Q8CPY5, Staphylococcus aureus, Q5HQV4 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 956 INIIDTPGHVDFT Lactobacillus fermentum, B2GDX1, Q03PV4, Q96RP9 Lactobacillus brevis, Lactobacillus B2G8Y0, A5VLK8, reuteri, Lactobacillus reuteri, Q88XY8, Q1WVA0, Lactobacillus plantarum, Lactobacillus Q8R602, Q250N5, salivarius, Fusobacterium nucleatum, B8G1W3, Q6A6L5, Desulfitobacterium hafniense, Q18CF4, Q97EH4, Desulfitobacterium hafniense, A0PXU3, A3DIZ9, Propionibacterium acnes, B9DYA6, A5N4P4, ptoclostridium difficile, Clostridium Q8F585, C3PKP1, acetobutylicum, Clostridium novyi, B050I4, B2GIL1, Clostridium thermocellum, Clostridium C5CC67, Q82DQ1, kluyveri, Clostridium kluyveri, P40173, B1W417 Corynebacterium efficiens, Corynebacterium aurimucosum, Finegoldia magna, Kocuria rhizophila, Micrococcus luteus, Streptomyces avermitilis, Streptomyces coelicolor, Streptomyces griseus 957 INIIDTPGHVDFTIE Lactobacillus delbrueckii, Q1GBM0, Q04C17, Q96RP9 VER Lactobacillus delbrueckii, Q74L90, Q046C7, Lactobacillus johnsonii, Lactobacillus A8YXK3, Q5FM92, gasseri, Lactobacillus helveticus, Q4JT40, Q39Y09, Lactobacillus acidophilus, B5EFP7, B3E7T2, Corynebacterium jeikeium, Geobacter A5V605 metallireducens, Geobacter bemidjiensis, Geobacter lovleyi, Sphingomonas wittichii 958 INIIDTPGHVDFTIE Desulfovibrio alaskensis Q30Z38 Q96RP9 VERALR 959 INNAAGNFI Bacillus subtilis O34717 Q16698 960 INSAVFPGLQGGP Methylobacterium sp. B0UML5 P34896 961 IPDYRGPNG Streptomyces coelicolor Q8CJM9 Q9NRC8 962 IPHNGCRPRK Methylobacterium extorquens, A9W4R7, B1LWQ1, P82912 Methylobacterium radiotolerans, B7L0S7, B1Z770 Methylobacterium extorquens, Methylobacterium populi 963 IPPPNVTGSLH Acinetobacter baylyi, Escherichia coli, Q6F8F0, Q8XCB3, P26640 Escherichia coli, Escherichia coli, Q8FAD1, P07118, Haemophilus influenzae, A5UEN9, P43834, Haemophilus influenzae, A5UBZ9, Q4QKA4, Haemophilus influenzae, Q7VN93, Q9HXH0, Haemophilus influenzae, Q48MF2, Q887M3, Haemophilus ducreyi, Pseudomonas Q4ZXI0, Q4KHT9, aeruginosa, Pseudomonas Q88P76, Q98LB1, savastanoi, Pseudomonas syringae, Q92037, A5V592 Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas putida, Rhizobium loti, Rhizobium meliloti, Sphingomonas wittichii 964 IPPPNVTGSLHLG Streptomyces coelicolor, O06851, Q82CA3 P26640 HA Streptomyces avermitilis 965 IPVIANGDI Haemophilus influenzae P44965 O95620 966 IQFKLADMA Bacillus subtilis O34421 P16219 967 IQNALGSDI Bacillus cytotoxicus, Bacillus A7GT99, A9VIP3, Q9BXR0 weihenstephanensis, Bacillus cereus, B7HE51, Q817W6, Bacillus cereus, Bacillus cereus, B7IIS9, Q634C7, Bacillus cereus, Bacillus thuringiensis, Q6HDA9, C1ESW1, Bacillus cereus, Bacillus cereus, B7HQH6, A0RJ24, Bacillus thuringiensis, Bacillus cereus, Q73064, B7JQ03, Bacillus cereus, Bacillus anthracis, Q81LH2, C3L6U6, Bacillus anthracis, Bacillus anthracis, C3P9A4, B9IYZ1, Bacillus cereus, Bacillus halodurans Q9KDI5 968 IQVYEETSG Clostridium perfringens, Clostridium Q8XJW5, Q0TPW7, P38606 perfringens, Clostridium perfringens, Q0SSI2, Q896K4, Clostridium tetani, Clostridium B2UWY4, B2TP91, botulinum, Clostridium botulinum, Q184E7, Q08636, ptoclostridium difficile, Enterococcus A8AUJ7, A3CK48, hirae, Streptococcus gordonii, Q1JNS8, Q1JDX0, Streptococcus sanguinis, B1ICC9, B5E552, Streptococcus pyogenes, B8ZK31, C10ES2, Streptococcus pyogenes, Q97QA8, A2RC97, Streptococcus pneumoniae, Q5XE50, Q1J8S5, Streptococcus pneumoniae, Q9A1Q3, Q1JIX5, Streptococcus pneumoniae, Q48VL3, P0DA06, Streptococcus pneumoniae, P0DA07, Q8P2U6, Streptococcus pneumoniae, B5XJH3 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 969 IRGHRRTYVGS ptoclostridium difficile Q180E4 Q86WA8 970 IRNFSIVAH Lactobacillus brevis, Lactobacillus Q03QU8, Q88VN0, Q8N442 plantarum, Lactobacillus fermentum, B2GBR9, B2G6W5, Lactobacillus reuteri, Lactobacillus A5VJE9, B0UFE0, reuteri, Methylobacterium sp., B8IMT0, A5I644, Methylobacterium nodulans, A7FXL9, B1KZP1, Clostridium botulinum, Clostridium A7GH10, B1ILM7, botulinum, Clostridium botulinum, C1FVU4, C3L3H1, Clostridium botulinum, Clostridium Q0SRD8, Q8XIS6, botulinum, Clostridium botulinum, Q0TNS2, A5N6L8, Clostridium botulinum, Clostridium Q2KDL5, B5ZXQ5, perfringens, Clostridium perfringens, Q1MMQ8, B3PYC6, Clostridium perfringens, Clostridium Q92SU3, Q98DV1 kluyveri, Rhizobium etli, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium etli, Rhizobium meliloti, Rhizobium loti 971 IRPRGGDFLY Parabacteroides distasonis A6L8P3 Q9NTM9 972 IRPRGGDFLYS Bacteroides fragilis, Bacteroides Q5L9Y1, Q64Q87, Q9NTM9 fragilis, Bacteroides thetaiotaomicron Q89ZG1 973 IRTVMITGD Bacillus cereus, Listeria Q73E41, Q8Y805 Q4VNC0 monocytogenes 974 IRTVMITGDN Rhizobium loti Q98GX6 Q4VNC1 975 IRTVMVTGD Pseudomonas aeruginosa, Rhizobium P57698, Q92XJ0 Q9H7F0 meliloti 976 IRTYNFPQNRVTD Bacillus licheniformis, Bacillus subtilis, Q65DV1, P45872, Q9UGC7 HRI Bacillus weihenstephanensis, Bacillus A9VSC7, A7GV79, cytotoxicus, Lactobacillus plantarum, Q88UT2, Q812I4, Bacillus cereus, Bacillus thuringiensis, Q6HAV4, Q630R9, Bacillus cereus, Bacillus cereus, Q72XC2, B9IRW2, Bacillus cereus, Bacillus anthracis Q81JX1 977 ISGAHLNPA Bacillus subtilis P18156 P29972 978 ISGAHLNPAV Pseudomonas aeruginosa Q9HWZ3 P29972 979 ISGGHFNPAV Escherichia coli, Escherichia coli, P60845, P60844, O94778 Escherichia coli Q8X6K6 980 ISGGHFNPAVS Rhizobium meliloti Q92NM3 O94778 981 ISGGHFNPAVSL Rhizobium meliloti Q92ZW9 O94778 982 ISRQLWWGH Lactobacillus sakei, Enterococcus Q38XD1, Q82ZW6, P26640 faecalis, Staphylococcus carnosus, B9DND4, Q6GG42, Staphylococcus aureus, Q7A0P4, A8Z2I4, Staphylococcus aureus, Q6G8R2, Q99TJ8, Staphylococcus aureus, A6QHJ8, Q5HFA8, Staphylococcus aureus, Q2FG72, A5ITI8, Staphylococcus aureus, Q2FXR8, A6U2D1, Staphylococcus aureus, Q2YTA0, Q931Q1, Staphylococcus aureus, A7X383, Q4L703, Staphylococcus aureus, Q5HNN9, Q8CS83, Staphylococcus aureus, Q49Y96, Q3K2S4, Staphylococcus aureus, Q8E1B5, Q99YS1, Staphylococcus aureus, Q8P040, Q4S5A4, Staphylococcus aureus, Q5M5J8, P0DG65, Staphylococcus aureus, P0DG64, Q97S45, Staphylococcus aureus, Q5XAW8, Q8DOU7, Staphylococcus haemolyticus, Q5M111, Q8DSL1, Staphylococcus epidermidis, Q8E650 Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus mutans, Streptococcus agalactiae 983 ISRQLWWGHRIPA Lactobacillus plantarum, Lactobacillus Q88UX7, Q74JZ8, P26640 johnsonii, Lactobacillus acidophilus Q5FKW5 984 ITAQNHGYA Clostridium acetobutylicum Q97FT2 P31327 985 ITEIYEGTSE Clostridium acetobutylicum P52042 P16219 986 ITEIYEGTSEI Clostridium propionicum G3KIM8 P16219 987 ITGASSGIG Listeria monocytogenes, P25145, Q4L8Y1 P56937 Staphylococcus haemolyticus 988 ITGASSGIGL Bacillus subtilis, Helicobacter pylori O32291, O05730 P56937 989 ITGPNMGGKST Ralstonia pickettii, Ralstonia B2U9E4, Q8Y093 P43246 solanacearum 990 ITGPNMGGKSTY Bacillus clausii, Edwardsiella ictaluri, Q5WFY3, C5BGI4, P43246 Haemophilus influenzae, P44834, Q9HY08, Pseudomonas aeruginosa, A6V1G8, B7V8C8, Pseudomonas aeruginosa, Q02R92, A4VJN9, Pseudomonas aeruginosa, Q48F92, Q4ZWP5, Pseudomonas aeruginosa, Q4KHE3, Q3KH79, Pseudomonas stutzeri, Pseudomonas C3KCT2 savastanoi, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens 991 ITGPNMSGKSTY Lactobacillus johnsonii, Lactobacillus P61668, B2GB17, Q15457 fermentum, Lactobacillus salivarius, Q1WT15, B3W9W4, Lactobacillus casei, Lactobacillus Q035Z2, Q048Y4, casei, Lactobacillus delbrueckii, Q5FLX5, Q03R33, Lactobacillus acidophilus, A8YTH9, Q1G938, Lactobacillus brevis, Lactobacillus Q38YR4, Q92BV3, helveticus, Lactobacillus delbrueckii, A0AIK5, B8DFS4, Lactobacillus sakei, Listeria innocua, C1L2V9, Q8Y789, Listeria welshimeri, Listeria Q71ZR7, Q03EQ7, monocytogenes, Listeria B9DPB9, A8AZU4, monocytogenes, Listeria A4W4J7, C1CTY2, monocytogenes, Listeria Q1JEH0, Q8NZ24, monocytogenes, Pediococcus A2RGX2, Q5X9F3, ntosaceus, Staphylococcus carnosus, Q3JYM3, B5XJ75, Streptococcus gordonii, Q1JJH0, Q1J9C1, Streptococcus suis, Streptococcus Q8DWW1, Q8E2R3, pneumoniae, Streptococcus Q48QT6, A3CR17, pyogenes, Streptococcus pyogenes, Q1J489, P0DC61, Streptococcus pyogenes, P0DC60, Q99XL8, Streptococcus pyogenes, B5E385, Q8DRW8, Streptococcus agalactiae, B9DW73, Q03MY4, Streptococcus pyogenes, Q5M1Z0, COMGC5, Streptococcus pyogenes, Q5M6I1, C0MAS5 Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus sanguinis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus mutans, Streptococcus uberis, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus equi, Streptococcus thermophilus, Streptococcus equi 992 ITKELIEIISGA Methylobacterium sp., B0UE40, A9W2R2, P36542 Methylobacterium extorquens, B1ZEE8, B7KUA3, Methylobacterium populi, B8IN02, C3M952, Methylobacterium extorquens, Q98EV7, B5ZSN8, Methylobacterium nodulans, Q92LK7, B3PQ69, Rhizobium sp., Rhizobium loti, Q1MAZ1 Rhizobium leguminosarum, Rhizobium meliloti, Rhizobium etli, Rhizobium leguminosarum 993 ITPTPLGEGK Aeromonas salmonicida, Aeromonas A4SPE5, A0KIN9 P11586 hydrophila 994 ITPTPLGEGKSTTT Desulfovibrio desulfuricans B8J0C2 P11586 IGLVQ 995 ITPVPGGVG Clostridium tetani, Geobacter Q894G6, Q39Z32, P13995 metallireducens, Geobacter Q74GN1 sulfurreducens 996 ITPVPGGVGP Lactobacillus gasseri, Lactobacillus Q044I0, Q74IM0, Q9H903 johnsonii, Staphylococcus Q8CPP4, Q5HQA7, epidermidis, Staphylococcus Q4L572, Q6GAF0, epidermidis, Staphylococcus A8Z1K5, A6QF52, haemolyticus, Staphylococcus Q2FI15, Q8NX95, aureus, Staphylococcus aureus, Q5HH21, Q2FZJ6, Staphylococcus aureus, Q99V34, Q7A697, Staphylococcus aureus, A7X0V3, A5IRV0, Staphylococcus aureus, A6U0N1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 997 ITPVPGGVGPMT Acinetobacter baylyi, Akkermansia Q6F9E6, B2UM17, P13995 muciniphila, Bacillus pumilus, Bacillus A8FF15, Q65HI8, licheniformis, Lactobacillus salivarius, Q1WUJ3, C4ZBG7, Eubacterium rectale, Bacteroides Q5LAX0, Q64RB7, fragilis, Bacteroides fragilis, Q8A7B8, A7ZCH3, Bacteroides thetaiotaomicron, A0RQ49, A3DEE6, Campylobacter concisus, B8J466, Q72F91, Campylobacter fetus, Clostridium A1VGV4, B9M769, thermocellum, Desulfovibrio A5GAM5, Q39WH4, desulfuricans, Desulfovibrio vulgaris, Q74EU7, Q7VGF6, Desulfovibrio vulgaris, Geobacter A4XY05, A4XXZ2, daltonii, Geobacter uraniireducens, Q48HJ1, Q88LI7, Geobacter metallireducens, Q8XZ10, Q2JZV0, Geobacter sulfurreducens, Q2KCC6, Q92RY3, Helicobacter hepaticus, Q989A7, Q93E15, Pseudomonas mendocina, Q1MLB6, Q92T88, Pseudomonas mendocina, A5VAA8, Q49WI7, Pseudomonas savastanoi, B9D045, Q3K2M6, Pseudomonas putida, Ralstonia Q8E168, Q8E6M3, solanacearum, Rhizobium etli, B5XM84, Q1JAV4, Rhizobium etli, Rhizobium meliloti, Q5X1324, Q1JL04, Rhizobium loti, Rhizobium A2RDM9, P0DF89, leguminosarum, Rhizobium Q1JG29, Q1J5U5, leguminosarum, Rhizobium meliloti, P0DF88, Q48SM7, Sphingomonas wittichii, Q7CN13, Q99YX2, Staphylococcus saprophyticus, Q97RI9, A8AW32, Staphylococcus carnosus, C0M7V0, B4U1W4, Streptococcus agalactiae, B9DUU0, Q03LK0, Streptococcus agalactiae, P96050, Q5M0P7, Streptococcus agalactiae, Q04L84, Q8DQD3, Streptococcus pyogenes, Q5M583, C0MD36, Streptococcus pyogenes, Q8DVC1 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus gordonii, Streptococcus equi, Streptococcus equi, Streptococcus uberis, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus equi, Streptococcus mutans 998 ITPVPGGVGPMTV Haemophilus influenzae, Q4QMI7, A5UAS4, P11586 AMLM Haemophilus influenzae, P44313, A5UHL4 Haemophilus influenzae, Haemophilus influenzae 999 ITSCTNTSNPSVM Corynebacterium diphtheriae Q6NH63 P21399 1000 ITVGILLSY Bacillus subtilis COSPB2 O95528 1001 ITVSEEVALKQA Streptococcus pyogenes Q99YC0 Q9H0R6 1002 IVAGGDGTL Staphylococcus carnosus B9DMT6 Q53H12 1003 IVEDIIDTG Streptococcus pyogenes, Q5XEL6, Q7CNQ9, P00492 Streptococcus pyogenes, P0DD40, P0DD41 Streptococcus pyogenes, Streptococcus pyogenes 1004 IVETEAYLG Listeria innocua, Listeria Q92D89, P58621, P29372 monocytogenes, Listeria B8DEK7, C1L1K0, monocytogenes, Listeria Q721N6, A0AH42, monocytogenes, Listeria Q4L8K2, Q5HLQ3, monocytogenes, Listeria welshimeri, Q8CRC1, B9DLR4, Staphylococcus haemolyticus, P65416, Q6G6X6, Staphylococcus epidermidis, A8Z534, Q5HDL2, Staphylococcus epidermidis, P65415, P65414, Staphylococcus carnosus, A6QJI5, Q2FVS1, Staphylococcus aureus, A5IVC5, Q2FEF3, Staphylococcus aureus, A7X5V7, A6U471, Staphylococcus aureus, Q2YYZ2, Q6GE90 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1005 IVKYSPDCII Bacillus methylotrophicus A7Z7J8 P07195 1006 IVLADADLD Lactobacillus casei A5YBJ3 P00352 1007 IVLMAQIGCFVP Clostridium acetobutylicum Q97119 P43246 1008 IVLVDDSIVRG Staphylococcus epidermidis, Q5HQA0, Q8CT30 Q06203 Staphylococcus epidermidis 1009 IVNAANSSL Escherichia fergusonii B7LT90 Q9BQ69 1010 IVNAANSSLLGGG Streptomyces griseus Q9KHE2 Q9BQ69 GVDG 1011 IVSNASCTTNC Aeromonas hydrophila, Aeromonas A0KGD2, A4SRF2 O14556 salmonicida 1012 IVSNASCTTNCLA Citrobacter freundii, Escherichia P24748, P24750, O14556 PLAKVI hermannii, Escherichia fergusonii, P0C8Z1, P24751 Escherichia vulneris 1013 IVVATPGRL Bacillus cereus Q81DF9 Q9GZR7 1014 IVVTDGERILGLGD Aeromonas hydrophila, Aeromonas A0KHR8, A4SKE9, P48163 salmonicida, Citrobacter koseri, A8AGN6, C5BCM3, Edwardsiella ictaluri, Enterobacter A4WAJ3, B1IRX9, sp., Escherichia coli, Escherichia coli, A8A036, P26616, Escherichia coli, Escherichia coli, B1XE70, C4ZWP8, Escherichia coli, Escherichia coli, B1LFD8, Q8FHH1, Escherichia coli, Escherichia B7LQX1, B7N4P2, fergusonii, Escherichia coli, B7LZ73, B7MUR3, Escherichia coli, Escherichia coli, B7L7H9, A7ZLS1, Escherichia coli, Escherichia coli, Q1RBT9, Q0THU1, Escherichia coli, Escherichia coli, A1AB75, B7NHU3, Escherichia coli, Escherichia coli, B7MMW1, B7URL9, Escherichia coli, Escherichia coli, B5Z1T9, Q8XAS9, Escherichia coli, Escherichia coli, A6T9K7, B5XX25, Klebsiella pneumoniae, Klebsiella B4ESY2 pneumoniae, Proteus mirabilis 1015 IYAAGDICT Bacillus halodurans, Bacillus cereus, Q9K7F3, Q816D9, Q8WU10 Bacillus cereus, Bacillus cereus, Q632D6, Q72YF6, Bacillus thuringiensis, Bacillus Q6HBX6, A0RKB9, thuringiensis, Bacillus anthracis, Q81XS0, A9VMZ3 Bacillus weihenstephanensis 1016 IYARGAQDMK Campylobacter jejuni, Campylobacter A8FMA1, B9KD35, Q03154 lari, Campylobacter jejuni, Q5HU53, A1W038, Campylobacter jejuni, Campylobacter Q0P9K4, A7H2V9, jejuni, Campylobacter jejuni, A7GX37, A7I005 Campylobacter curvus, Campylobacter hominis 1017 IYRIDHYLGKE Pseudomonas aeruginosa O68282 P11413 1018 KADIGIAMG Staphylococcus haemolyticus Q4L970 P50993 1019 KAEKNAVSHR Ralstonia solanacearum Q8XXF4 Q9BY32 1020 KAFAAGADIKEMQ Rhizobium meliloti Q52995 P30084 1021 KAGRNRWLG Sphingomonas wittichii A5V5Z9 Q5T653 1022 KASGLAAGKGV Fusobacterium nucleatum Q8REV7 P22102 1023 KATSNICTAQALL Neisseria gonorrhoeae B4RN40 P23378 1024 KATSNICTAQALLA Neisseria gonorrhoeae, Neisseria Q5F761, A1KV85, P23378 N meningitidis, Neisseria meningitidis, A9M1P7, Q9JT86 Neisseria meningitidis 1025 KDDRTGTGT Lactobacillus plantarum, Lactobacillus Q88W05, A8YUW0, P04818 helveticus, Corynebacterium Q6NIF2, Q8NS38, diphtheriae, Corynebacterium A4QCI7, Q8FR47 glutamicum, Corynebacterium glutamicum, Corynebacterium efficiens 1026 KDGEAVWFG Lactobacillus delbrueckii, P94869, P94870, Q13867 Lactobacillus helveticus, Lactobacillus P94868 delbrueckii 1027 KDGPLDMRMD Aeromonas hydrophila, Aeromonas A0KPY0, A4SI48, A6NJ78 salmonicida, Aggregatibacter C6AKG2, C6BYH4, aphrophilus, Desulfovibrio salexigens, A5UCX6, Q4QLG6, Haemophilus influenzae, P45057, Q0I1E1, Haemophilus influenzae, A5UIQ3, B2FNN0, Haemophilus influenzae, B4SJW8 Haemophilus somnus, Haemophilus influenzae, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1028 KDVKWILGQDPY Listeria monocytogenes, Listeria Q720K2, Q8Y7P6, P13051 HGP monocytogenes, Listeria innocua Q92CI1 1029 KDVKWILGQDPY Clostridium perfringens, Clostridium Q0TUH0, Q0SWB8, P13051 HGPNQAHG perfringens, Clostridium perfringens Q8XNR7 1030 KDVKWILGQDPY Haemophilus parasuis B8F6C3 P13051 HGPNQAHGL 1031 KDYYEILGVSR Edwardsiella ictaluri C5B7L8 Q9NXW2 1032 KDYYKILGV Propionibacterium acnes Q6A662 Q99615 1033 KEEIFGPVL Pseudomonas aeruginosa Q9I702 P30038 1034 KEEIFGPVM Stenotrophomonas maltophilia, B2FQ90, B4SHW0 P05091 Stenotrophomonas maltophilia 1035 KEGLALINGTQ Fusobacterium nucleatum Q8RDU4 P42357 1036 KEIFLRELISN Bacillus subtilis, Clostridium P46208, C3KXP4, P14625 botulinum, Clostridium botulinum, A5I3130, A7FV42, Clostridium botulinum, Clostridium C1FPN9, B1IN79, botulinum, Clostridium botulinum, A7GEU9, B1KUN4 Clostridium botulinum, Clostridium botulinurn 1037 KEIFLRELISNASD Bacillus clausii, Bacillus Q5WJE6, A7ZAI5, P14625 A methylotrophicus, Bacillus halodurans Q9KE51 1038 KERKGDYLG Clostridium kluyveri, Clostridium A5N3K4, B8I598 P17812 cellulolyticum 1039 KERRGDYLG Methylobacterium sp., Desulfovibrio B0U802, Q72BL2, Q9NRF8 vulgaris, Desulfovibrio vulgaris, A1VDL2, B8DJR8, Desulfovibrio vulgaris, Desulfovibrio Q310T4, B1M5Q9, alaskensis, Methylobacterium B8IP92, B1Z9R0, radiotolerans, Methylobacterium B7KUU9, B3Q30M2, nodulans, Methylobacterium populi, Q92QA0, Q2K871, Methylobacterium extorquens, Q1MGC4, B5ZPZ7, Rhizobium etli, Rhizobium meliloti, B9DME0, Q4L808, Rhizobium etli, Rhizobium Q49Z73, Q8CNI2, leguminosarum, Rhizobium Q5HM95 leguminosarum, Staphylococcus carnosus, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 1040 KEVILSGGA Staphylococcus aureus, Q8NUM0, Q6G664 Q8NE62 Staphylococcus aureus 1041 KEVTLLGQNVN Pseudomonas stutzeri, Pseudomonas A4VQY3, A4XYW1 Q965Z6 mendocina 1042 KEVTLLGQNVNS Clostridium beijerinckii, Geobacter A6LWI1, A5G670, Q965Z6 uraniireducens, Geobacter Q74644 sulfurreducens 1043 KFYQASTSE Aggregatibacter Q9JRN5 Q60547 actinomycetemcomitans 1044 KFYTEDGNWDLV Staphylococcus warneri, Q9KW19, Q2PUJ9, P04040 GNNTP Staphylococcus epidermidis, Q8CPD0, Q5HPK8, Staphylococcus epidermidis, Q4L643 Staphylococcus epidermidis, Staphylococcus haemolyticus 1045 KGAMLTHGN Haemophilus influenzae P46450 Q9UKU0 1046 KGILLYGPPG Kocuria rhizophila B2GIP2 P46459 1047 KGLYKKARAGE Citrobacter koseri, Enterobacter sp., A8ANW4, A4WDV5, Q43252 Escherichia fergusonii, Escherichia B7LWK5, Q1R7U1, coli, Escherichia coli, Escherichia coli, Q8FEJ2, A1AEU4, Escherichia coli, Escherichia coli, B7MYQ5, B7NT94, Escherichia coli, Escherichia coli, B7UHG9, B7MKM4, Escherichia coli, Escherichia coli, B1LQ71, B7N6Y0, Escherichia coli, Escherichia coli, B616E0, P0A6J1, Escherichia coli, Escherichia coli, B1XCS6, A8A3M9, Escherichia coli, Escherichia coli, C4ZZQ4, B7LXG2, Escherichia coli, Escherichia coli, B5Z3B2, P0A6J2, Escherichia coli, Escherichia coli, B7LEG8, A7ZQJ4, Escherichia coli, Escherichia coli, Q0TEA8, B1IU59, Klebsiella pneumoniae, Klebsiella A6TD42, B5XV31 pneumoniae 1048 KGLYKKARAGEI Aeromonas hydrophila, Aeromonas A0KP33, A4SRG6 O43252 salmonicida 1049 KGRTPNPDI Finegoldia magna B0S3R4 O75648 1050 KGSLLWVLD Clostridium cellulolyticum, Clostridium B812Q5, Q895H2 P20585 tetani 1051 KIDPYINID Helicobacter pylori, Helicobacter Q9ZM99, O25116, P17812 pylori, Helicobacter pylori Q1CUG1 1052 KIFITHLHGDH Bacillus methylotrophicus, Bacillus A7Z6F0, Q65HN6, Q9H777 licheniformis, Lactobacillus plantarum, Q88VG6, B2GBD1, Lactobacillus fermentum, Bacillus B9IXD7, Q731F6, cereus, Bacillus cereus, Bacillus B7HNQ7, Q635E2, cereus, Bacillus cereus, Bacillus Q6HE20, A0RID9, thuringiensis, Bacillus thuringiensis, C1ER14, B7JLZ5, Bacillus cereus, Bacillus cereus, Q81M88, C3LJR8, Bacillus anthracis, Bacillus anthracis, C3P7S4, Q03QP5, Bacillus anthracis, Lactobacillus B7HB12, B7IWQ5, brevis, Bacillus cereus, Bacillus Q818V3, A9VG79, cereus, Bacillus cereus, Bacillus B2G6S0, A5VJA0, weihenstephanensis, Lactobacillus A7GSG2, Q03W55, reuteri, Lactobacillus reuteri, Bacillus B8DBV5, Q03F36, cytotoxicus, Leuconostoc B4EUI8, A3CNR9, mesenteroides, Listeria Q8DT90, B9DUP5, monocytogenes, Pediococcus C0MAM9, A8AWX4, ntosaceus, Proteus mirabilis, C0MDJ9, B4U3M1, Streptococcus sanguinis, B5XL36, Q48TY8, Streptococcus mutans, Streptococcus Q8P1A6, A2REY2, uberis, Streptococcus equi, Q1JH87, Q1J705, Streptococcus gordonii, Q5XCH7, P0DF23, Streptococcus equi, Streptococcus Q1JM42, P0DF22, equi, Streptococcus pyogenes, Q1JC59, P60199 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 1053 KIGHGGTLD Streptococcus pneumoniae, Q97QJ3, Q8CWR2, Q8WWH5 Streptococcus pneumoniae, Q04KA7, A8AX28, Streptococcus pneumoniae, P0DD49, P0DD48, Streptococcus gordonii, Q3K189, P65856, Streptococcus pyogenes, P65857, A2RE90, Streptococcus pyogenes, Q1JLG7, Q1J6C1, Streptococcus agalactiae, P65858, Q5XBX7, Streptococcus agalactiae, P65859, Q1JBI5, Streptococcus agalactiae, Q1JGK3, Q48TB3, Streptococcus pyogenes, Q5LZV2, Q5M4G2 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus thermophilus 1054 KIIRKEIPA Haemophilus influenzae P44956 P49773 1055 KILILDEAT Lactobacillus brevis Q03PY5 O15440 1056 KILNLRVFED Bifidobacterium longum, B3DQN7, B7G087, Q8TEA8 Bifidobacterium longum, Q8G4Q2 Bifidobacterium longum 1057 KIRLTGGEP Haemophilus influenzae, P45311, Q4QJR9, Q9NZB8 Haemophilus influenzae, A5UFB4, A5UBK4, Haemophilus influenzae, B2FUM0, B45L67 Haemophilus influenzae, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1058 KIRLTGGEPL Bacillus cytotoxicus, Bacillus A7GU01, Q65DY5, Q9NZB8 licheniformis, Bacillus A7Z9P0, P39757, methylotrophicus, Bacillus subtilis, A7GWA5, A0RMJ2, Campylobacter curvus, Q4ZU05, Q48HV8, Campylobacter fetus, Pseudomonas Q882V6, B1JCVV0, syringae, Pseudomonas savastanoi, Q88E69, A5VZZ2, Pseudomonas syringae, Q1I6J5, B0KST1, Pseudomonas putida, Pseudomonas Q8Y0K4, B3PQ08, putida, Pseudomonas putida, Q2K7L4, B5ZRM8 Pseudomonas entomophila, Pseudomonas putida, Ralstonia solanacearum, Rhizobium etli, Rhizobium etli, Rhizobium leguminosarum 1059 KIRLTGGEPLIRP Pseudomonas fluorescens Q3KA58 Q9NZB8 1060 KKLDVLSND Acinetobacter baylyi Q6F982 P09467 1061 KKRVFSGIQPTG Helicobacter pylori, Helicobacter P56396, Q9ZJX4 Q9UGM6 pylori 1062 KKVSLELGG Escherichia coli, Pseudomonas P25526, Q88RC0, Q3SY69 putida, Pseudomonas aeruginosa Q9I6M5 1063 KKVSLELGGKSP Staphylococcus saprophyticus, Q49Z69, Q5HMA0, Q3SY69 Staphylococcus epidermidis, Q8CNI5, Q4L803, Staphylococcus epidermidis, Q8NVG4, Q6G7I8, Staphylococcus haemolyticus, Q2FWD6, Q7A4D8, Staphylococcus aureus, Q99SD6, Q5HE78, Staphylococcus aureus, Q2FF06, Q6GEV3, Staphylococcus aureus, Q2YUN1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1064 KKWCDDYFF Citrobacter koseri A8ADF0 P36551 1065 KLAAFMKKF Bacillus subtilis P80862 Q9Y617 1066 KLAKQYHPD Clostridium phytofermentans A9KKT9 Q9NX36 1067 KLAMKYHPD Rhizobium sp., Rhizobium meliloti C3MC05, Q92T07 Q9UBS3 1068 KLFVDTDAD Bacillus halodurans, Bacillus Q9KDD8, A7GT59, Q9BZX2 cytotoxicus, Bacillus cereus, Bacillus Cl E555, Q6HDE5, thuringiensis, Bacillus cereus, Bacillus B7JP70, Q634G4, cereus, Bacillus thuringiensis, Bacillus A0RIZ3, B7IYN4, cereus, Bacillus cereus, Bacillus Q730F4, B9IYE5, cereus, Bacillus cereus, Bacillus B7HQD8, Q81LK8, anthracis, Bacillus anthracis, Bacillus C3L5Y6, C3P969, anthracis, Bacillus cereus, Bacillus B7HE15, Q817Z5 cereus 1069 KLHTGRSRNDQV Acinetobacter baumannii, B0VDE4, B7H1L9, P04424 Acinetobacter baumannii, B71338, A3M1E0, Acinetobacter baumannii, B0VMC7, B2I1W9, Acinetobacter baumannii, Q6FFB2, A4SIM6, Acinetobacter baumannii, A0KFV4, A8AKW2, Acinetobacter baumannii, A3DBU0, Q8XMJ8, Acinetobacter baylyi, Aeromonas Q0TTA6, B8I1A0, salmonicida, Aeromonas hydrophila, A7GGQ8, A0Q1Z1, Citrobacter koseri, Clostridium B1IK07, A9KQ51, thermocellum, Clostridium C3L1U2, C1FU67, perfringens, Clostridium perfringens, A5I5A3, A7FWU5, Clostridium cellulolyticum, Clostridium B1KXY0, B8DN65, botulinum, Clostridium novyi, A1VEQ1, Q72D36, Clostridium botulinum, Clostridium B8IZ53, C5BC57, phytofermentans, Clostridium A4WG51, B5Z062, botulinum, Clostridium botulinum, Q8X730, B6I5H6, Clostridium botulinum, Clostridium B7M714, B7LA60, botulinum, Clostridium botulinum, A7ZUH8, Q1R3V1, Desulfovibrio vulgaris, Desulfovibrio Q8FB96, Q0TAA0, vulgaris, Desulfovibrio vulgaris, A1AID8, B7MR51, Desulfovibrio desulfuricans, B7MI96, B7LUN5, Edwardsiella ictaluri, Enterobacter B7NFR0, P11447, sp., Escherichia coli, Escherichia coli, B1IVB8, A8A768, Escherichia coli, Escherichia coli, C5A0Q9, B1XBC5, Escherichia coli, Escherichia coli, B7NU40, B7UNT6, Escherichia coli, Escherichia coli, Q4QM89, Q0I2U1, Escherichia coli, Escherichia coli, P44314, A5UDR3, Escherichia coli, Escherichia coli, A5UHW3, B8F531, Escherichia fergusonii, Escherichia A6TGE4, B5XZ16, coli, Escherichia coli, Escherichia coli, B4F1G9, C3K426, Escherichia coli, Escherichia coli, A4VGX6, B7V5F3, Escherichia coli, Escherichia coli, Q02EA0, P50987, Escherichia coli, Haemophilus Q4K3X1, A6VE40, influenzae, Haemophilus somnus, A4XNY5, Q88694, Haemophilus influenzae, P59618, Q48QD3, Haemophilus influenzae, Q500N3, B1J1V0, Haemophilus influenzae, Q1I314, B0KH03, Haemophilus parasuis, Klebsiella Q3K4S8 pneumoniae, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas fluorescens, Pseudomonas stutzeri, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas syringae, Pseudomonas putida, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas fluorescens 1070 KLSGGEKQRVAI Rhizobium loti Q98KI3 O75027 1071 KLTPNVTDI Lactobacillus casei, Lactobacillus Q038Z3, Q74J29 Q12882 johnsonii 1072 KLTPNVTDIV Lactobacillus helveticus, Lactobacillus A8YVZ9, Q5FJB5, Q12882 acidophilus, Lactobacillus delbrueckii, Q047M3, Q1G864, Lactobacillus delbrueckii, P77887 Lactobacillus plantarum 1073 KLYVRRVFITDD Rhizobium loti Q98JB6 P14625 1074 KMKETAEAYLG Rhizobium loti Q98DD1 P11021 1075 KMSKSLGNV Bacillus halodurans Q9K9V0 P26640 1076 KMSKSLGNVI Lactobacillus johnsonii, Q74JX6, Q846V6, P26640 Staphylococcus epidermidis, Q8CSX1, Q5HPZ9, Staphylococcus epidermidis, Q4L5P4, Q2YXH4, Staphylococcus epidermidis, Q6GHP2, P41972, Staphylococcus haemolyticus, A8Z3N1, P67509, Staphylococcus aureus, Q5HGN8, P67508, Staphylococcus aureus, A6QG93, A5IS79, Staphylococcus aureus, Q2FZ82, Q2FHP4, Staphylococcus aureus, A6U113, A7X1D8 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1077 KMSKSLGNVVDP Rhizobium meliloti Q92PX0 Q96GW9 1078 KMVHNGIEY Bacillus subtilis P12013 P52209 1079 KNRYVGRTFIQP Bacillus subtilis P00497 Q06203 1080 KNTYGTGCFLL Fusobacterium nucleatum, Q8RHZ9, Q0TMA0, Q14409 Clostridium perfringens, Clostridium Q8XHD3, Q0SQ01, perfringens, Clostridium perfringens, Q97JG4, A6M1Y8 Clostridium acetobutylicum, Clostridium beijerinckii 1081 KPDILLLDEP Bacillus subtilis P37494 Q86UQ4 1082 KPHVNVGTIGHVD Acinetobacter baylyi, Acinetobacter Q6FF97, A3M1F6, P49411 HG baumannii, Acinetobacter baumannii, B7H1K5, B2UQY9, Akkermansia muciniphila, Q250N4, B8G1W4, Desulfitobacterium hafniense, A4W5A0, P0A6N2, Desulfitobacterium hafniense, P0A6N3, Q1R5U4, Enterobacter sp., Escherichia coli, P0CE48, B1IVA7, Escherichia coli, Escherichia coli, Q0TA85, A1AlF3, Escherichia coli, Escherichia coli, A8A779, A7ZUJ2, Escherichia coli, Escherichia coli, Q1R5Y2, A1AGM6, Escherichia coli, Escherichia coli, P0CE47, B1IPW0, Escherichia coli, Escherichia coli, Q0TCC0, A8A5E6, Escherichia coli, Escherichia coli, A7ZSL4, Q7TTF9, Escherichia coli, Escherichia coli, Q0I1U9, P43926, Escherichia coli, Haemophilus A5UHC1, Q7VJ74, ducreyi, Haemophilus somnus, A6TEX7, Q5F5Q8, Haemophilus influenzae, P64027, A1KRF9, Haemophilus influenzae, Helicobacter P64026, P48864, hepaticus, Klebsiella pneumoniae, P09591, Q02T82, Neisseria gonorrhoeae, Neisseria A6UZH4, A4XZ92, meningitidis, Neisseria meningitidis, A4VHM8, A4VHL6, Neisseria meningitidis, Neisseria Q4K519, Q8XGZ0 gonorrhoeae, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas stutzeri, Pseudomonas stutzeri, Pseudomonas fluorescens, Ralstonia solanacearum 1083 KPNIVLIMVD Clostridium perfringens, Clostridium Q8XNV1, Q0TUK6 P54793 perfringens 1084 KPRYLMGVG Lactobacillus plantarum, Desulfovibrio Q88V05, Q30XF7, Q9BXR0 alaskensis, Enterococcus faecalis Q837E7 1085 KPVIAAVNGYAFG Citrobacter koseri, Escherichia coli, A8ALR7, P31551, P30084 GG Escherichia coli, Escherichia coli, B1IRE0, Q8FLA6, Escherichia coli, Escherichia coli, Q0TLV3, B1LFW9, Escherichia coli Q8XA35 1086 KQFTTVVAD Escherichia coli, Escherichia coli, P0A868, P0A867, P37837 Escherichia coli P0A869 1087 KQRVAIARA Lactobacillus sakei, Lactobacillus Q38WL5, Q03P57, O75027 brevis, Escherichia coli, Escherichia P30750, Q1RFY9, coli, Escherichia coli, Escherichia coli, P63355, P63356, Escherichia coli, Haemophilus Q0TLD2, Q7VM95, ducreyi, Haemophilus influenzae, P44785, Q4QMH4, Haemophilus influenzae, Q0I5E9, Q7VI92, Haemophilus somnus, Helicobacter Q2FJI0, Q2GOV2, hepaticus, Staphylococcus aureus, Q5HIL5, Q93DA2 Staphylococcus aureus, Staphylococcus aureus, Streptococcus mutans 1088 KRIHEYKRQL Escherichia coli P0AC86 P06737 1089 KSGYGLDLE Pseudomonas entomophila, Q1I3R1, Q87UL9, Q96NU7 Pseudomonas syringae, Q48CD3, Q4ZLW0 Pseudomonas savastanoi, Pseudomonas syringae 1090 KSGYGLDLETE Ralstonia solanacearum Q8XW31 Q96NU7 1091 KSLDFYTRVLG Pseudomonas putida P16635 Q04760 1092 KSNILLLGPTG Clostridium acetobutylicum Q97FT7 O76031 1093 KSNILLLGPTGSG Clostridium tetani Q891J8 O76031 KTLLAQT 1094 KSNILLLGPTGSG Clostridium novyi, ptoclostridium A0Q2L0, Q180E8, O76031 KTLLAQTLA difficile, Clostridium beijerinckii, A6LT28, B9E684, Clostridium kluyveri, Clostridium A5N2K7, C6E2S9, kluyveri, Geobacter sp., Geobacter B5EI28, Q74C83, bemidjiensis, Geobacter Q39UH3, B9M0Y2, sulfurreducens, Geobacter A5GFA1, Q820F8, metallireducens, Geobacter daltonii, B1VXA8, Q9F316 Geobacter uraniireducens, Streptomyces avermitilis, Streptomyces griseus, Streptomyces coelicolor 1095 KSNILLLGPTGSG Clostridium botulinum, Clostridium B1L1D6, A7GIH1, O76031 KTLLAQTLAK botulinum, Clostridium botulinum, B1IND6, A5I6W0, Clostridium botulinum, Clostridium C1FLA5, C3KU76, botulinum, Clostridium botulinum, A7FYI1, Q0ST54, Clostridium botulinum, Clostridium Q0TQK3, Q8XKK2, perfringens, Clostridium perfringens, B2TPB8, B2UX12 Clostridium perfringens, Clostridium botulinum, Clostridium botulinum 1096 KTFAYTNHT Escherichia coli P00490 P06737 1097 KTRLIGPNCPGVI Bacillus subtilis P80865 P53597 1098 KVEIAGPGF Pseudomonas putida, Pseudomonas B0KN43, Q88CU1, P54136 putida, Pseudomonas putida, A5WAC2, A4XPN9, Pseudomonas mendocina, A4VH02, Q87V03, Pseudomonas stutzeri, Pseudomonas Q4ZZF5, A6VDH2, syringae, Pseudomonas syringae, Q48PI2, Q9HUC8, Pseudomonas aeruginosa, Q02EW6, B7V3E4 Pseudomonas savastanoi, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa 1099 KVEIAGPGFIN Citrobacter koseri, Edwardsiella A8AFG5, C5B832, P54136 ictaluri, Enterobacter sp., Escherichia A4WBN1, B5YR22, coli, Escherichia coli, Escherichia coli, Q8XCH2, P11875, Escherichia coli, Escherichia coli, B1XHE4, C4ZQG0, Escherichia coli, Escherichia coli, B7L7S9, Q1RAQ8, Escherichia coli, Escherichia coli, Q0TGV6, A1AC37, Escherichia coli, Escherichia coli, B7MBT5, B7M2G7, Escherichia coli, Escherichia coli, B7USQ3, B6I0S7, Escherichia coli, Escherichia coli, B1J0L2, Q8FGQ0, Escherichia coli, Escherichia coli, B7MW70, B1LCZ5, Escherichia coli, Escherichia coli, B7NBM7, B7NS42, Escherichia coli, Escherichia coli, A8A178, A7ZN02, Escherichia fergusonii, Klebsiella B7LPH0, B5XPZ2, pneumoniae, Klebsiella pneumoniae, A6TB43, B4ETN5, Proteus mirabilis, Stenotrophomonas B2FJW0, B4STE2 maltophilia, Stenotrophomonas maltophilia 1100 KVFYVWFDA Streptomyces avermitilis Q82F60 P56192 1101 KVIDATGKLV Lactobacillus delbrueckii, Q1G867, A8YVZ5, Q9BPU6 Lactobacillus helveticus, Lactobacillus Q047M6 delbrueckii 1102 KVLIANRGEIA Pseudomonas aeruginosa P37798 Q96RQ3 1103 KVVILGQDPYH Lactobacillus delbrueckii, Q1GB22, Q04BG7, P13051 Lactobacillus delbrueckii, Q74K70, A8YUE7, Lactobacillus johnsonii, Lactobacillus Q5FL46 helveticus, Lactobacillus acidophilus 1104 KVVILGQDPYHG Arcobacter butzleri, Helicobacter A8EWN8, Q7VGS1 P13051 hepaticus 1105 KVVILGQDPYHGP Lactobacillus plantarum Q88YG1 P13051 1106 KVVILGQDPYHGP Bacillus cytotoxicus, Bacillus cereus, A7GVE5, Q72X51, P13051 NQAHGL Bacillus halodurans, Bacillus cereus, Q9K682, Q814M9, Bacillus cereus, Bacillus cereus, B7HG60, B7IRS8, Bacillus cereus, Bacillus cereus, Q630K2, B9IS32, Bacillus cereus, Bacillus cereus, B7HYF9, B7JHM3, Bacillus weihenstephanensis, Bacillus A9VSJ0, Q6HAN7, thuringiensis, Bacillus thuringiensis, A0RLI1, C1EQ68, Bacillus cereus, Bacillus anthracis, Q81JQ4, C3LFS7, Bacillus anthracis, Bacillus anthracis, C3P2F8, P67077, Staphylococcus aureus, A8YZS8, P67076, Staphylococcus aureus, Q5HI95, P67075, Staphylococcus aureus, A6QEN4, Q2G0J7, Staphylococcus aureus, A5IQD5, A6TZ58, Staphylococcus aureus, A7WZ22, Q2FJ62, Staphylococcus aureus, Q6GJ88, Q2Y583, Staphylococcus aureus, Q6GBQ6, Q8CQ65, Staphylococcus aureus, Q5HRG5 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1107 KYHPDKNPD Rhizobium etli, Rhizobium Q2KDW7, Q6RSN5, Q8WW22 radiobacter, Rhizobium etli, B3PXH2, Q1MN12 Rhizobium leguminosarum 1108 LAAGNTVVI Staphylococcus epidermidis, Q5HLA3, Q8CN24 O75891 Staphylococcus epidermidis 1109 LAAQSIGEP Helicobacter hepaticus, Uncultured Q7VJ82, B1GZ76 O95602 termite 1110 LACARIGAIHS Escherichia coli P77495 Q9H6R3 1111 LADDMGLGKT Bacillus subtilis P94593 Q2NKX8 1112 LADYLVVNVSSPN Corynebacterium striatum, Q9FB59, Q8FTC6, Q02127 T Corynebacterium efficiens, Q8NQC0, A4QEA4 Corynebacterium glutamicum, Corynebacterium glutamicum 1113 LASRDWSR Helicobacter pylori, Helicobacter Q9ZMP0, O06913 P31040 pylori 1114 LATKAREGKL Bacillus subtilis P21883 P10515 1115 LAYEPVWAIG Rhizobium etli Q2JZQ2 P60174 1116 LAYEPVWAIGTGK Bacteroides thetaiotaomicron, Q8A0U2, A6LFF0 P60174 TA Parabacteroides distasonis 1117 LAYEPVWAIGTGK Bacteroides vulgatus, Porphyromonas A6KXL2, Q7MWI7, P60174 TAT gingivalis, Porphyromonas gingivalis B2RII9 1118 LAYSGGLDT Clostridium phytofermentans, A9KHL4, C4Z4C1 P00966 Eubacterium eligens 1119 LAYSGGLDTS Lactobacillus plantarum, Clostridium P59603, A3DBU1, P00966 thermocellum, Clostridium Q0TTA5, Q8XMJ7, perfringens, Clostridium perfringens, B2TQ23, B2UYI0, Clostridium botulinum, Clostridium C5CAM5, Q8E7N1, botulinum, Micrococcus luteus, Q8E272, Q3K3Q4, Streptococcus agalactiae, A4VXZ4, A4W488, Streptococcus agalactiae, Q8CVVZ0, Q03IP8, Streptococcus agalactiae, Q5M2K2, Q5LXZ8, Streptococcus suis, Streptococcus Q04MW7, Q8DRI5, suis, Streptococcus mutans, B1I814, A3CQQ4, Streptococcus thermophilus, A8AUN6 Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus gordonii 1120 LDEADRMLDMGF Escherichia coli P21507 Q92841 1121 LDEATSALD Campylobacter jejuni, Haemophilus Q0P9C4, Q57180, Q9NUT2 influenzae, Neisseria meningitidis, Q9JXR3, Q9JW59, Neisseria meningitidis, Neisseria Q5F4X8, P0A2V1, gonorrhoeae, Rhizobium radiobacter, Q983H5, P18767, Rhizobium loti, Rhizobium meliloti, Q2K342, Q1MAB5 Rhizobium etli, Rhizobium leguminosarum 1122 LDEPTAGLDP Bacillus subtilis, Lactobacillus P70970, Q1WSB9, Q8WWZ4 salivarius, Lactobacillus sakei, Q38UU0, Q18CI9, ptoclostridium difficile, Clostridium Q0TMS8, Q8XHV3, perfringens, Clostridium perfringens, Q890R3, Q97EK9, Clostridium tetani, Clostridium Q839D4, Q8CRI7, acetobutylicum, Enterococcus Q5HM28, Q8DRS0, faecalis, Staphylococcus epidermidis, Q48QM3, Q1JEC9, Staphylococcus epidermidis, Q1J450, A2RH10, Streptococcus mutans, Streptococcus Q1JJD0, Q7CMM8, pyogenes, Streptococcus pyogenes, Q1J983, Q5X9B6, Streptococcus pyogenes, Q99XI2, P0CZ27, Streptococcus pyogenes, P0CZ26, A3CRB8, Streptococcus pyogenes, Q8DMY0, Q04HV8, Streptococcus pyogenes, Q97N51, Q03I83, Streptococcus pyogenes, Q5M244, Q5LXJ4 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus 1123 LDEPTNHLD Bacillus subtilis, Bacillus subtilis, O05519, O34512, O9UG63 Bacillus subtilis Q06476 1124 LDGDNVRHGLN Bacillus licheniformis, Bacillus Q65JT8, A8FD25, pumilus, Clostridium kluyveri A5N960 O95340 1125 LDGDNVRHGLNR Rhizobium tropici, Rhizobium sp., P52978, O07309, O095340 Rhizobium sp., Rhizobium meliloti P72339, P13442 1126 LDGGMGTMIQ Pseudomonas aeruginosa, Q9I2Q2, O33465 Q99707 Pseudomonas putida 1127 LDIGTGTGL Bacteroides fragilis, Bacteroides Q5LCS1, Q64TX7, Q9NVM4 fragilis, Bacteroides thetaiotaomicron Q8A9H7 1128 LDIPLLFET Rhizobium etli, Rhizobium loti Q2KE98, Q98DY2 Q8WVC6 1129 LDIPLLFETK Rhizobium meliloti Q92TE9 Q8WVC6 1130 LDKLRHTHV Lactobacillus casei, Lactobacillus Q038M5, B3WER5 O60841 casei 1131 LDLCAAPGGK Citrobacter koseri, Enterobacter sp., A8AQI3, A4WF97, Q9H649 Escherichia coli, Escherichia coli, Q1R644, A1AGI0, Escherichia coli, Escherichia B7MCQ4, B7LRQ5, fergusonii, Escherichia coli, B7N0S9, Q8FD12, Escherichia coli, Escherichia coli, B7NLK8, B5YT08, Escherichia coli, Escherichia coli, Q8XEE5, B6I202, Escherichia coli, Escherichia coli, B7M0Z4, B7LHZ0, Escherichia coli, Escherichia coli, B7UK12, A7ZSH7, Escherichia coli, Escherichia coli, B1LGP5, P36929, Escherichia coli, Escherichia coli, B1IQ11, A8A593, Escherichia coli, Escherichia coli, C4ZUE3, B1X6E1, Escherichia coli, Escherichia coli, B7NDR0, B5XNC2, Klebsiella pneumoniae, Klebsiella A6TEU2, B4F1L5 pneumoniae, Proteus mirabilis 1132 LDQLKQFTTVVAD Ralstonia pickettii, Ralstonia B2U9W5, Q8Y014 P37837 TGDF solanacearum 1133 LDSARFRYF Rhizobium loti Q98EC4 Q6ZMR3 1134 LDSARFRYL Staphylococcus epidermidis, Q8CMZ0, Q5HL31 P00338 Staphylococcus epidermidis 1135 LDSRGNPTVE Lactobacillus salivarius, Lactobacillus Q1WSY0, B2GAM0 P13929 fermentum 1136 LDSRGNPTVEV Lactobacillus sakei Q38Y18 P13929 1137 LDTARFRFL Bacillus caldotenax, Bacillus P10655, Q59244 Q9BYZ2 caldolyticus 1138 LDTKGPEIRT Bacillus licheniformis, Bacillus subtilis, P51181, P80885, P30613 Escherichia coli, Escherichia coli, P0AD61, P0AD62, Staphylococcus saprophyticus Q49YC7 1139 LDTKGPEIRTG Clostridium acetobutylicum O08309 P30613 1140 LDVAGGTGDIAFR Rhizobium etli, Rhizobium etli, Q2KDB0, B3PZ92, Q5HYK3 Rhizobium leguminosarum, Q1MME0, B5ZYK8, Rhizobium leguminosarum, Q98GV1, Q925K7, Rhizobium loti, Rhizobium meliloti, C3MCY6 Rhizobium sp. 1141 LDVGCGSGIL Clostridium phytofermentans A9KKT8 Q86X55 1142 LDVGCGSGILS Campylobacter lari, Campylobacter B9KDE1, A7ZES6, Q86X55 concisus, Campylobacter fetus, A0RQL1, O07678, Helicobacter pylori, Helicobacter Q17WN8, B2USL4, acinonychis, Helicobacter pylori, Q1CUC6, Q9ZM65, Helicobacter pylori, Helicobacter Q7VHY7 pylori, Helicobacter hepaticus 1143 LDVLINNAGI Bacillus subtilis, Bacillus subtilis, Q8KWT4, P39640, Q9HBH5 Bacillus amyloliquefaciens Q8KW59 1144 LDVLVNNAG Streptomyces violaceoruber P16543 P16152 1145 LDVLVNNAGI Staphylococcus aureus, Q5HGK2, P0A0I0, P16152 Staphylococcus aureus, P0A0H9, Q6G9Y2, Staphylococcus aureus, Q6GHK4, P99093 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1146 LDYVDLYLLH Pseudomonas putida Q02198 P17516 1147 LEFVQFHPT Ralstonia solanacearum Q8XQG4 P31040 1148 LEGHLRSILG Bacillus subtilis O32076 Q14254 1149 LEINPLWT Haemophilus parasuis, Rhizobium loti B8F4Q2, Q98KT9 P53396 1150 LEINPLWTKD Methylobacterium extorquens P53594 P53396 1151 LELGGKSPLI Pseudomonas putida, Pseudomonas P0A391, P0A390 Q35Y69 sp. 1152 LELIASENF Desulfovibrio vulgaris, Desulfovibrio A1VEK5, Q72CT0, P34896 vulgaris, Desulfovibrio alaskensis, Q30YL7, B8DJF7, Desulfovibrio vulgaris, Geobacter B5E8U0, C6E348, bemidjiensis, Geobacter sp., Q39V87, A5GF66, Geobacter metallireducens, B9M0W5, Q74CR5, Geobacter uraniireducens, Geobacter B3E1Z8 daltonii, Geobacter sulfurreducens, Geobacter lovleyi 1153 LELLEGKILPGV Geobacter lovleyi B3E9Q7 P07205 1154 LELRVPFLD Bacillus subtilis P54420 P08243 1155 LEYRGYDSAG Bacillus clausii, Lactobacillus Q5WLG7, Q88YE7, Q06210 plantarum, Campylobacter jejuni, Q9PMT4, O26060, Helicobacter pylori, Helicobacter Q9ZJ94, P64228, pylori, Staphylococcus aureus, P64227, Q8NVE6, Staphylococcus aureus, Q6G7F8, Q5HE49, Staphylococcus aureus, Q6GE53 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1156 LFDEPTTGLD Bacillus subtilis P46903 Q9H222 1157 LFGTIDSWL Lactobacillus acidophilus Q5FHZ6 Q14409 1158 LFTLAESLGG Escherichia coli P00935 P32929 1159 LFVGSEGTLG Bacillus subtilis P94535 Q86WU2 1160 LGAGKTTLL Escherichia coli, Pseudomonas P24203, Q9HZQ2 Q5RIA9 aeruginosa 1161 LGAGKTTLLN Pseudomonas chlororaphis P31521 Q5RIA9 1162 LGAQWGDEGKGK Haemophilus parasuis, Haemophilus B8F8E6, A5UIZ2, Q8N142 influenzae, Haemophilus influenzae, Q4QL68, P45283, Haemophilus influenzae, A5UCM6, Q7VKR5, Haemophilus influenzae, Q82ER6, Q9X8P6, Haemophilus ducreyi, Streptomyces B1VMC3 avermitilis, Streptomyces coelicolor, Streptomyces griseus 1163 LGDVYVNDAFGTA Lactobacillus plantarum Q88YH5 P07205 HR 1164 LGFPCNQFG Staphylococcus epidermidis, Q8C5R9, Q6GHD0, P18283 Staphylococcus aureus, P64291, Q6G9Q8, Staphylococcus aureus, P64290, P99097, Staphylococcus aureus, Q5HGC7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1165 LGGAKVADK Propionibacterium acnes Q6A9J3 P07205 1166 LGGRVKTLHP Bacteroides thetaiotaomicron Q8A155 P31939 1167 LGGTCVNVGCVP Pseudomonas aeruginosa P23189 P00390 KK 1168 LGGTCVNVGCVP Haemophilus influenzae P43783 P00390 KKVM 1169 LGGTCVNVGCVP Escherichia coli P06715 P00390 KKVMW 1170 LGHVQRGGTPSA Streptomyces coelicolor O08333 Q01813 FDR 1171 LGLPTGSTPL Fusobacterium nucleatum, Q8REG1, C5BGA6 P46926 Edwardsiella ictaluri 1172 LGMGADGHT Aggregatibacter P70715 O95479 actinomycetemcomitans 1173 LGNNKITDI Listeria monocytogenes P25147 Q9BXN1 1174 LGPNGAGKST Streptomyces ucetius P32010 Q8WWZ7 1175 LGPNGAGKTT Bacillus subtilis, Bacillus subtilis O07016, P42246 Q86UK0 1176 LGPNGAGKTTTI Bacillus subtilis P54592 Q86UK0 1177 LGPPGAGKGTQA Geobacter sulfurreducens, Rhizobium Q749A8, Q93FE6, P54819 meliloti, Uncultured termite B1GZA3 1178 LGPPGSGKGT Stenotrophomonas maltophilia, B4SI37, B2FT48 P27144 Stenotrophomonas maltophilia 1179 LGPTGSGKT Eubacterium eligens, Clostridium C4Z1T5, B8I8F6, O76031 cellulolyticum, Corynebacterium C3PI25, Q6NFU7, aurimucosum, Corynebacterium A4QGA7, Q8NN26, diphtheriae, Corynebacterium C4LJV6 glutamicum, Corynebacterium glutamicum, Corynebacterium kropnstedtii 1180 LGPTGSGKTLLA Desulfitobacterium hafniense, Q24SJ9, B8FV10 O76031 Desulfitobacterium hafniense 1181 LGPTGSGKTLLAQ Clostridium thermocellum, Geobacter A3DJ11, B3E1Z3 O76031 TLA lovleyi 1182 LGRELGLPE Rhizobium sp., Rhizobium meliloti C3MCS5, Q92SQ3 P49915 1183 LGRKSGKGFY Clostridium acetobutylicum P52041 P40939 1184 LGSSQRFGVP Pseudomonas fluorescens Q4K416 P23378 1185 LGSVGEPIN Methylobacterium radiotolerans, B1M0M1, A9W5V0, Q9NUB1 Methylobacterium extorquens, B1ZB59, B7KPN8, Methylobacterium populi, Q88DW6, Q91558, Methylobacterium extorquens, Q98ET8 Pseudomonas putida, Pseudomonas aeruginosa, Rhizobium loti 1186 LGTHDFSAF Clostridium thermocellum A3DJK8 Q8N0Z8 1187 LGVDKNASE Lactobacillus johnsonii, Lactobacillus Q74IT7, Q044A8, Q99615 gasseri, Fusobacterium nucleatum Q70WY6 1188 LGVPFNIASY Leuconostoc mesenteroides Q03YZ8 P04818 1189 LGVPFNIASYALL Parabacteroides distasonis, A6LIC2, Q5L9L6, P04818 Bacteroides fragilis, Bacteroides Q64PV5, A6L1Q8, fragilis, Bacteroides vulgatus, Q8A639 Bacteroides thetaiotaomicron 1190 LGVPFNIASYALLT Lactobacillus casei, Lactobacillus Q039F7, P00469, P04818 casei, Staphylococcus epidermidis, P0C0M5, P0A0M5, Staphylococcus aureus, Q5HMP6, P0C0M4 Staphylococcus epidermidis, Staphylococcus epidermidis 1191 LGVSRDASD Lactobacillus delbrueckii, Q1G9R3, Q049W7 Q9H819 Lactobacillus delbrueckii 1192 LHDGPPYANG Lactobacillus brevis, Lactobacillus Q030I3, Q1WTA9, Q9N5E4 salivarius, Lactobacillus reuteri, B2G6L2, B2GB86, Lactobacillus fermentum, A7I157, B9KD44, Campylobacter hominis, P41257, Q5HU41, Campylobacter lari, Campylobacter C6BV89, Q30ZF7, jejuni, Campylobacter jejuni, Q747X9, Q4QLU5, Desulfovibrio salexigens, A5UIA3, P43824, Desulfovibrio alaskensis, Geobacter A5UDA6, Q7VP34, sulfurreducens, Haemophilus B6JNR5, P56456, influenzae, Haemophilus influenzae, Q1CRK7, Q9ZJJ1, Haemophilus influenzae, B2UVG2, B5Z943, HaemophiluS influenzae, Q17ZG3, A0AKC5, Haemophilus ducreyi, Helicobacter Q929Z6, Q8Y5N8, pylori, Helicobacter pylori, Q71Y01, C1KWW3, Helicobacter pylori, Helicobacter B8DBR2, Q03EY9, pylori, Helicobacter pylori, A5VY52, Q88Q92, Helicobacter pylori, Helicobacter B1JF83, B0KM84, acinonychis, Listeria welshimeri, B7V0A3, Q4ZYJ4, Listeria innocua, Listeria Q9HVM4, Q48NK6, monocytogenes, Listeria Q02GB7, A6VBU7, monocytogenes, Listeria Q1I4S5, C3KDX4, monocytogenes, Listeria Q889E4, P18330, monocytogenes, Pediococcus A4VI60, Q4K5U4, ntosaceus, Pseudomonas putida, Q3K6L5, A4XQV5, Pseudomonas putida, Pseudomonas Q983N4, Q8NX29, putida, Pseudomonas putida, Q6GA19, P0DG43, Pseudomonas aeruginosa, P0DG42, Q48SL8, Pseudomonas syringae, Q5XB14, Q8P068, Pseudomonas aeruginosa, Q99YW3, Q8DNW4, Pseudomonas savastanoi, Q04JB0, C1CSS4, Pseudomonas aeruginosa, B5E709, B1I721, Pseudomonas aeruginosa, Q8DVD3, C1CFN0, Pseudomonas entomophila, Q5M4X2, Q5M0Q5, Pseudomonas fluorescens, Q03L88, P0CB61, Pseudomonas syringae, B2IRR4, C1CLZ8, Pseudomonas fluorescens, C1C8P8, B8ZM55, Pseudomonas stutzeri, Pseudomonas Q8E177, Q3K2N4, fluorescens, Pseudomonas Q8E6N1, A3CLP4, fluorescens, Pseudomonas A8AW24 mendocina, Rhizobium loti, Staphylococcus aureus, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus sanguinis, Streptococcus gordonii 1193 LHDGPPYANGD Bacillus subtilis, Bacillus clausii, Q45477, Q5WFI3, Q9NSE4 Ralstonia pickettii B2UAQ4 1194 LHLGNYLGAI Rhizobium loti, Rhizobium meliloti Q98C31, Q92SI9 Q9UGM6 1195 LHRAFSVFLF Streptomyces coelicolor, Q9X7Q6, BlVTW2, Q13907 Streptomyces griseus, Streptomyces Q82MJ7 avermitilis 1196 LHTGRSRNDQV Clostridium beijerinckii, Desulfovibrio A6M1Z5, Q30Y139, P04424 alaskensis, Eubacterium eligens, C4Z0V2, B3E9X6, Geobacter lovleyi, Geobacter daltonii, B9M377, A5GDA7, Geobacter uraniireducens, Geobacter Q74GT9, Q39Z69, sulfurreducens, Geobacter C6E6Y9, B5ED16, metallireducens, Geobacter sp., Q9JVG7, Q9K0G8, Geobacter bemidjiensis, Neisseria A9M2R4, A1KSP4, meningitidis, Neisseria meningitidis, Q5FA15, B2UA10, Neisseria meningitidis, Neisseria Q8XWV7, Q49W99 meningitidis, Neisseria gonorrhoeae, Ralstonia pickettii, Ralstonia solanacearum, Staphylococcus saprophyticus 1197 LIANRGEIA Bacillus subtilis P49787 Q96RQ3 1198 LIASENFAS Rhizobium loti Q98A81 P34896 1199 LIGADPREI Aeromonas hydrophila, Proteus A0KJ32, B4EZU8 Q9Y697 mirabilis 1200 LIGQFGVGFYSAF Methylobacterium populi, B1Z9Y8, A9W1H7, P14625 Methylobacterium extorquens, B7KPG0 Methylobacterium extorquens 1201 LILDEATSALD Acinetobacter baylyi, Bacillus subtilis, Q6F9X0, P71082, Q9NUT2 Escherichia coli, Escherichia coli, Q1RDU4, Q8FJB1, Escherichia coli, Escherichia coli, Q0TJD9, P60752, Escherichia coli, Ralstonia P60753, Q8XXB6 solanacearum 1202 LILDEPTSG Escherichia coli P37624 Q9H221 1203 LISPFVGRILDW Haemophilus parasuis B8F5Q3 P37837 1204 LITGASSGIGL Acinetobacter baylyi Q6F7B8 P56937 1205 LIYTSGTTG Bacillus subtilis P39846 Q5FVE4 1206 LKGHRSVGG Bacillus cereus, Bacillus cereus, Q81BC0, Q638W1, Q9Y617 Bacillus cereus, Bacillus thuringiensis, Q734W9, Q6HGI0, Bacillus anthracis, Bacillus circulans, C3P210, Q59196, Listeria monocytogenes, Listeria Q8Y3L0, Q71VT6, monocytogenes, Listeria innocua, Q926T3, Q885T5, Pseudomonas syringae, A6V2Q8, C3K6J5, Pseudomonas aeruginosa, Q02PX3, B7V9J9, Pseudomonas fluorescens, Q9HZ66, A4XTE7, Pseudomonas aeruginosa, Q88M07, Q1IDA2, Pseudomonas aeruginosa, Q4ZQ94 Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas syringae 1207 LKGKQGRFR Methylobacterium sp., Fusobacterium B0UHX5, Q8RHI7, O14802 nucleatum, Bifidobacterium A1A316, Q8G515, adolescentis, Bifidobacterium longum, B3DTE1, Q8A470, Bifidobacterium longum, Bacteroides Q64NJ8, Q5L898, thetaiotaomicron, Bacteroides fragilis, A6KYK2, A6LE80, Bacteroides fragilis, Bacteroides B8DWJ5, Q0SQD7, vulgatus, Parabacteroides distasonis, P0C2E8, Q0TMN9, Bifidobacterium animalis, Clostridium A4QBG3, Q8NT25, perfringens, Clostridium perfringens, Q8FS96, B1VES2, Clostridium perfringens, Q6NJF6, C3PKN2, Corynebacterium glutamicum, C4LL70, Q4JT33, Corynebacterium glutamicum, B2GIK0, B1ZGS1, Corynebacterium efficiens, A9W8N9, B7KN46, Corynebacterium urealyticum, BlLY42, B8IS79, Corynebacterium diphtheriae, O33431, Q6A6K7, Corynebacterium aurimucosum, Q92QH6, Q1MIE8, Corynebacterium kropnstedtii, B3PW60, Q2K9M3, Corynebacterium jeikeium, Kocuria Q98N65, A5VBZ7, rhizophila, Methylobacterium populi, P0C0D9, B1W441, Methylobacterium extorquens, Q82DQ4, Q8CJT1 Methylobacterium extorquens, Methylobacterium radiotolerans, Methylobacterium nodulans, Porphyromonas cangingivalis, Propionibacterium acnes, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli, Rhizobium loti, Sphingomonas wittichii, Streptococcus pyogenes, Streptomyces griseus, Streptomyces avermitilis, Streptomyces coelicolor 1208 LKGRDLLTL Bacillus halodurans Q9K8V8 P00480 1209 LKLIADVGLVG Arcobacter butzleri A8EV83 A4D1E9 1210 LKLIADVGLVGFP Campylobacter fetus, Campylobacter A0RR37, A7I166, A4D1E9 N hominis, Campylobacter jejuni, Q0PC41, A7H029, Campylobacter curvus, A8FJQ1, Q5HX70, Campylobacter jejuni, Campylobacter A1VXH9 jejuni, Campylobacter jejuni 1211 LKNDTFLRA Neisseria meningitidis, Neisseria Q9K041, A1KT40, P06132 meningitidis, Neisseria meningitidis, Q9JV52, A9M3L2, Neisseria meningitidis, Neisseria B4RK59, Q5F9N1 gonorrhoeae, Neisseria gonorrhoeae 1212 LLAAGQSST Pseudomonas aeruginosa, Ralstonia Q9RPF3, Q8XSF6 P49279 solanacearum 1213 LLDEPTAGLDP Listeria monocytogenes, Listeria Q8Y7R4, Q720M2 O94911 monocytogenes 1214 LLDGFPRTL Lactobacillus sakei, Enterococcus Q38UT2, Q839E3 Q9UIJ7 faecalis 1215 LLDMKIFVDTD Leuconostoc citreum B1MXP1 Q9NWZ5 1216 LLDVAGGTGDIAF Methylobacterium nodulans B81J00 Q5HYK3 R 1217 LLGGGGVDG Listeria monocytogenes, Listeria Q8Y3S3, Q71W03, Q9BQ69 monocytogenes, Listeria innocua Q926Y8 1218 LLGHNGAGKST Bacillus cereus Q737I0 Q4W5N1 1219 LLGPNGAGK Bacillus subtilis, Streptomyces P94374, Q9RKC6, Q8WWZ7 coelicolor, Streptomyces avermitilis Q82HA2 1220 LLGPNGAGKST Escherichia coli P36879 Q8WWZ7 1221 LLGPNGAGKTTT Haemophilus influenzae P45073 Q86UK0 1222 LLGPNGAGKTTTI Bacillus subtilis O31427 Q86UK0 1223 LLGPPGAGKGTQ Methylobacterium extorquens, A9W4R9, B1LWQ5, P54819 Methylobacterium radiotolerans, B1Z772, B7L0S9 Methylobacterium populi, Methylobacterium extorquens 1224 LLGPPGAGKGTQ Acinetobacter baylyi, Acinetobacter Q6FD71, B0VSA9, P54819 A baumannii, Acinetobacter baumannii, A3M3G1, B0V9Q9, Acinetobacter baumannii, B2HVT0, B7GXT4, Acinetobacter baumannii, B7I8U4, Q97EJ9, Acinetobacter baumannii, Q18CH9, B1KSK4, Acinetobacter baumannii, Clostridium A5N4R8, B9DYD0, acetobutylicum, ptoclostridium C3KVN0, B1IGD3, difficile, Clostridium botulinum, A5I7I5, C1FMT0, Clostridium kluyveri, Clostridium A7FZ52, A7GJ53, kluyveri, Clostridium botulinum, A0PXW7, Q890Q5, Clostridium botulinum, Clostridium B0RZT0, B9M6F7, botulinum, Clostridium botulinum, A5GAW3, Q2K9J5, Clostridium botulinum, Clostridium B3PWU2, Q98N36, botulinum, Clostridium novyi, A5V5Y1 Clostridium tetani, Finegoldia magna, Geobacter daltonii, Geobacter uraniireducens, Rhizobium etli, Rhizobium etli, Rhizobium loti, Sphingomonas wittichii 1225 LLHGDLWSGN Enterobacter aerogenes, Escherichia P46381, P77739, Q9H479 coli, Escherichia coli, Klebsiella P58065, P46382 pneumoniae 1226 LLHGFPEFWY Bacillus subtilis O31581 Q8IUS5 1227 LLLDEPTNHLD Bacillus subtilis, Escherichia coli, P39115, P43672, Q9UG63 Haemophilus influenzae, Rhizobium Q57242, P12622, radiobacter, Staphylococcus P23212 epidermidis 1228 LLLDEPTNHLDL Bacillus subtilis O31716 Q9UG63 1229 LLLDEPTNHLDLD Haemophilus influenzae P44808 Q9UG63 A 1230 LLNYQTMVCD Rhizobium meliloti, Rhizobium Q92O11, B5ZQP8, P23378 leguminosarum, Rhizobium etli, Q2K813, B3PP20 Rhizobium etli 1231 LLYGPPGCGKTLI Streptomyces griseus B1W303 Q8NBU5 AKA 1232 LMAKDLGLAQ Pseudomonas aeruginosa Q9I5I6 P31937 1233 LMAQIGCFVP Parabacteroides distasonis A6LG92 P43246 1234 LMKDAIKPNL Desulfitobacterium hafniense, Q251P8, Q0TMI3, P11586 Clostridium perfringens, Clostridium A0PXN0, Q0SQ82, novyi, Clostridium perfringens, Q8XHL4, A6LPL1, Clostridium perfringens, Clostridium A7GJB8, B1IGY1, beijerinckii, Clostridium botulinum, A5I7P9, A7FZB0, Clostridium botulinum, Clostridium C3KVU4, C1FND0, botulinum, Clostridium botulinum, B2TI29, B2UXU5, Clostridium botulinum, Clostridium B1KTC6 botulinum, Clostridium botulinum, Clostridium botulinum, Clostridium botulinurn 1235 LMRLDKPIG Pseudomonas mendocina A4Y0P0 Q96H96 1236 LMRLDKPIGT Haemophilus somnus, Pseudomonas Q0I0W3, A4VGN3 Q96H96 stutzeri 1237 LNERHYGAL Bacillus cereus Q732Z5 P07738 1238 LNHASIIDG Bacillus licheniformis, Bacillus subtilis, Q65ML1, Q8KZM9, O75600 Desulfovibrio desulfuricans, B8J3V0, B5EEV8, Geobacter bemidjiensis, Geobacter B3EAE0 lovleyi 1239 LNLIDTPGHVDF Fusobacterium nucleatum Q8RFD1 Q8N442 1240 LNLRVFEDE Clostridium perfringens, Clostridium Q0SRP4, Q8XJ24, Q8TEA8 perfringens, Clostridium perfringens Q0TP24 1241 LNPARDLGPR Streptococcus pneumoniae, P0A3Q8, P0A3Q7 Q96P58 Streptococcus pneumoniae 1242 LNRKVLADLA Desulfovibrio vulgaris, Desulfovibrio B8DPM9, C6BRG8 Q9BYC9 salexigens 1243 LNRRKGPAV Rhizobium meliloti, Rhizobium loti Q92KW2, Q98DZ1 Q9Y2Z2 1244 LPAGTYCDV Streptomyces thermoviolaceus, P27350, P08486 P04746 Streptomyces hygroscopicus 1245 LPDLGPIGANGLA Streptomyces coelicolor Q952B5 O93099 N 1246 LPGTLPVLN Clostridium acetobutylicum Q97EX9 O75879 1247 LPGVGQNLQDHL Proteus mirabilis, Pseudomonas B4EX94, Q48CM7, Q8NE62 E savastanoi, Pseudomonas syringae, Q4ZM63, Q88AE7, Pseudomonas syringae, A4XPI5 Pseudomonas mendocina 1248 LPHIGSATH Citrobacter koseri, Enterobacter sp., A8ARD9, A4W577, Q9UBQ7 Enterobacter agglomerans, P58000, B7LTG7, Escherichia fergusonii, Klebsiella B5XMZ4, A6TFG7 pneumoniae, Klebsiella pneumoniae 1249 LPNSRIMIHQP Campylobacter jejuni, Campylobacter Q5HWX6, P54413, Q16740 jejuni, Campylobacter jejuni, A7H1R0, A8FJZ3, Campylobacter jejuni, Campylobacter A1VXS0, Q5F914, jejuni, Neisseria gonorrhoeae, Q9JU33, Q9JZ38, Neisseria meningitidis, Neisseria A1KUD9, A9LZN9 meningitidis, Neisseria meningitidis, Neisseria meningitidis 1250 LPVFLLGHSMGG Bacillus subtilis O34705 Q99685 1251 LPVMVWIHGG Bacillus subtilis P37967 Q9UKY3 1252 LQRIYGISFP Finegoldia magna B0S169 A2RTX5 1253 LQTREQHIRR Stenotrophomonas maltophilia, B45567, B2FQE7 P23378 Stenotrophomonas maltophilia 1254 LQYRYLDLR Leuconostoc mesenteroides Q03WL7 Q6PI48 1255 LRGRGGAGFPTG Rhizobium meliloti P56913 P49821 1256 LRLQYRYLDLR Lactobacillus salivarius Q1WTU9 Q6PI48 1257 LRPETAQGIF Bacillus cereus, Bacillus cereus, Q632E8, Q72YG8, P41250 Bacillus anthracis, Bacillus Q81XT3, Q6HBZ1, thuringiensis, Clostridium tetani, Q899G6, B9DNL1, Staphylococcus carnosus, Q2YT14, P67035, Staphylococcus aureus, P67034, A8Z4A4, Staphylococcus aureus, Q6G902, Q6GGD5, Staphylococcus aureus, P99129, A6QHA8, Staphylococcus aureus, Q5HFJ5, A7X2W2, Staphylococcus aureus, Q2FY08, A5IT93, Staphylococcus aureus, Q2FGF8, A6U237, Staphylococcus aureus, Q5HNY2, Q8CSD5, Staphylococcus aureus, Q4L6R5, Q49Y08 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus 1258 LRPHVVWFGE Escherichia coli, Escherichia coli, Q8FIM4, Q8X8E0, Q9NXA8 Escherichia coli P75960 1259 LRVFEDESG Leuconostoc citreum B1MZI4 Q8TEA8 1260 LRVVDASIMP Acinetobacter baumannii, B7I895, B7GYG5, Q8NE62 Acinetobacter baumannii, B0V945, B0VST3, Acinetobacter baumannii, B2HV79, Q6FDF9, Acinetobacter baumannii, B6I074, A7ZWV4, Acinetobacter baumannii, B7M2V5, B7L439, Acinetobacter baylyi, Escherichia coli, A7ZI50, P17444, Escherichia coli, Escherichia coli, B1J0W6, B1XE52, Escherichia coli, Escherichia coli, Q1RFM3, B7MCD0, Escherichia coli, Escherichia coli, B5Z1R0, Q8X6C6, Escherichia coli, Escherichia coli, B7N8L3, B7UJG4, Escherichia coli, Escherichia coli, Q0TKW1, Q8FKI9, Escherichia coli, Escherichia coli, B1LIJ7, A6T613, Escherichia coli, Escherichia coli, C3K3D3, A5WA97, Escherichia coli, Escherichia coli, Q3K5H3, Q4K4K7, Klebsiella pneumoniae, Q1IG70, Q88CVV6, Pseudomonas fluorescens, B0KN19, A6VEI3, Pseudomonas putida, Pseudomonas Q9HTJ2, B7V5R3, fluorescens, Pseudomonas Q02DZ0 fluorescens, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa 1261 LRYDLTVPFARY Parabacteroides distasonis, A6LIF7, Q5LAE0, P12081 Bacteroides fragilis, Bacteroides Q64OS2, Q8A6N7, fragilis, Bacteroides thetaiotaomicron, A6KXA6, Q7MTB3 Bacteroides vulgatus, Porphyromonas gingivalis 1262 LSCQLYQRS Acinetobacter baumannii, B7H0P4, B7I4U0, P04818 Acinetobacter baumannii, Q6FER7, A0KG32, Acinetobacter baylyi, Aeromonas A4SIW7, P11044, hydrophila, Aeromonas salmonicida, A7Z5T3, P54081, Bacillus subtilis, Bacillus E0U0H8, A8FEB9, methylotrophicus, Bacillus Q9K7B5, Q5WDS1, amyloliquefaciens, Bacillus subtilis, Q1WU17, A5VJK9, Bacillus pumilus, Bacillus halodurans, Q03S95, Q4JX59, Bacillus clausii, Lactobacillus A6TDG3, C1KWH4, salivarius, Lactobacillus reuteri, Q8Y626, Q92AD4, Lactobacillus brevis, Corynebacterium B8DDM8, Q71YE1, jeikeium, Klebsiella pneumoniae, A0AJY0, Q8Y0U6, Listeria monocytogenes, Listeria Q92NQ5, Q98KH9, monocytogenes, Listeria innocua, Q1ME82, Q2K6G8, Listeria monocytogenes, Listeria Q49XN8, P67048, monocytogenes, Listeria welshimeri, Q6G9D4, P67046, Ralstonia solanacearum, Rhizobium A5ISV8, A7X2B3, meliloti, Rhizobium loti, Rhizobium P67047, A6U1P7, leguminosarum, Rhizobium etli, Q6GGY0, A8Z406, Staphylococcus saprophyticus, Q2YY40, Q5HFZ6, Staphylococcus aureus, Q2FYK5, A6QGX8, Staphylococcus aureus, Q2FH11, Q4L6D7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus 1263 LSCQLYQRSGD Lactobacillus sakei, Q38WX8, Q6A761 P04818 Propionibacterium acnes 1264 LSDELNHASIIDG Bacillus cereus, Bacillus anthracis, Q81I05, Q81V80, Q75600 Staphylococcus aureus, Q5HIC5, P60121, Staphylococcus aureus, Q8NXY3, Q6GBT7, Staphylococcus aureus, P60120, Q6GJB8 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1265 LSGCGVYDG Escherichia coli P0ABU5 P30042 1266 LSGGEKQRI Escherichia coli P77279 P33897 1267 LSGGQKQRI Bacillus subtilis, Bacillus subtilis, O07550, P54718, Q9NRK6 Escherichia coli, Escherichia coli, P77265, P22520, Escherichia coli, Rhizobium sp., Q9EXN5, P55469, Rhizobium meliloti Q92LX3 1268 LSGGQKQRIAIAR Bacillus subtilis O31707 Q9NRK6 A 1269 LSGGQKQRL Bacillus subtilis, Pediococcus P45861, P36497, Q9NUT2 acidilactici, Staphylococcus aureus, Q2G2M9, Q6GFJ1, Staphylococcus aureus, Q5HEQ8, Q99T13, Staphylococcus aureus, Q2FFM9, Q7A0J1, Staphylococcus aureus, Q6G868, Q7A4T3, Staphylococcus aureus, Q2YU20 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1270 LSGGQKQRV Bacillus clausii, Bacillus licheniformis, Q5WCI1, Q65P77, P33527 Clostridium tetani, Clostridium Q895C4, Q8XK20, perfringens, Corynebacterium Q6NJ07, Q8Y454, diphtheriae, Listeria monocytogenes, Q71WH7, Q3K506, Listeria monocytogenes, Q4K441, Q87UI3, Pseudomonas fluorescens, Q49ZE0 Pseudomonas fluorescens, Pseudomonas syringae, Staphylococcus saprophyticus 1271 LSGGQKQRVA Lactobacillus sakei, Lactobacillus Q38UT9, Q1WSB8, Q9NP78 salivarius, Lactobacillus delbrueckii, Q1GBJ0, Q839D5, Enterococcus faecalis, Q8CQ57, Q5HRU5, Staphylococcus epidermidis, Q8CRI6, Q5HM27, Staphylococcus epidermidis, Q5HDY6, Q2FW34, Staphylococcus epidermidis, Q2FER7, Q8NVB5, Staphylococcus epidermidis, Q6G799, Q99S47, Staphylococcus aureus, Q7A470, Q6GEL3, Staphylococcus aureus, Q8NY21, Q6GC27, Staphylococcus aureus, Q6GJL2, Q2YYM4, Staphylococcus aureus, Q7A7E3, Q99WE1, Staphylococcus aureus, Q2YVT7, Q8DRR9, Staphylococcus aureus, Q8DWR3, Q3JYF4, Staphylococcus aureus, Q8E2L2, A3CRB9, Staphylococcus aureus, Q1J982, P0C0E9, Staphylococcus aureus, P0CZ29, Q1J449, Staphylococcus aureus, A2RH11, Q1JEC8, Staphylococcus aureus, Q7CMM7, P0CZ28, Staphylococcus aureus, Q5X9B5, Q48QM2, Staphylococcus aureus, Q1JJC9, P0C0E8 Staphylococcus aureus, Staphylococcus aureus, Streptococcus mutans, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus sanguinis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 1272 LSGGQKQRVS Enterococcus faecalis Q832R5 P33527 1273 LSGGQRQRI Acinetobacter baylyi, Bacillus Q6F9A8, Q9K876, O60706 halodurans, Pseudomonas Q03024, Q88AS5, aeruginosa, Pseudomonas syringae, Q88CL2 Pseudomonas putida 1274 LSGGQRQRV Bacillus subtilis, Escherichia coli, P94360, Q8FKF5, Q15438 Rhizobium etli, Rhizobium loti, Q2K4V4, Q98G42, Rhizobium meliloti, Rhizobium Q9Z3R9, Q1MCN6, leguminosarum, Rhizobium Q1MFL8 leguminosarum 1275 LSGGVDSAVAA Uncultured termite B1GZY9 O75648 1276 LSGGVDSTV Desulfovibrio maeticus C4XSN8 P49915 1277 LSGHTHAGQIFP Helicobacter pylori, Helicobacter O25685, Q9ZM43 Q6ZT21 pylori 1278 LSGPSGAGKSTL Helicobacter pylori, Helicobacter P56103, Q1CUI1, Q16774 pylori, Helicobacter pylori Q9ZMB7 1279 LSIPVIANG Haemophilus influenzae P44606 Q9NX74 1280 LSMANAGPNTNG Staphylococcus haemolyticus Q4L4W9 A0A0B4J2A2 SQFF 1281 LSMANAGPNTNG Staphylococcus epidermidis, Q5HQK8, Q8CT84, A0A0B4J2A2 SQFFI Staphylococcus epidermidis, Q5XAQ1 Streptococcus pyogenes 1282 LSMFPYPSG Aeromonas salmonicida, Aeromonas A4SJW8, A0KN87, Q15031 hydrophila, Arcobacter butzleri, A8ERV3, A7I0M0, Campylobacter hominis, B9KCS8, A7GZ81, Campylobacter lari, Campylobacter Q0I5C5, A5UDF4, curvus, Haemophilus somnus, Q4QLY8, P43827, Haemophilus influenzae, A5UI62, Q7VIY7 Haemophilus influenzae, Haemophilus influenzae, Haemophilus influenzae, Helicobacter hepaticus 1283 LSMFPYPSGKLH Acinetobacter baylyi, Acinetobacter Q6F817, B0VKP9, Q15031 MGHVR baumannii, Acinetobacter baumannii, B0V5H2, B2HTC4, Acinetobacter baumannii, B7I5I5, B7H051, Acinetobacter baumannii, A9M162, Q5FAJ3, Acinetobacter baumannii, Neisseria B4RNT1, Q9JW39, meningitidis, Neisseria gonorrhoeae, Q9JXT2, A1KS07, Neisseria gonorrhoeae, Neisseria Q4ZN90, Q1I4G7, meningitidis, Neisseria meningitidis, B0KJW8, Q88DN1, Neisseria meningitidis, Pseudomonas A5W9H9, B1J150, syringae, Pseudomonas entomophila, Q87VX3, Q4K5H6, Pseudomonas putida, Pseudomonas Q48DN1, C3K2L2, putida, Pseudomonas putida, A6V0C2, Q9HX33, Pseudomonas putida, Pseudomonas B7V9C9, Q025F5, syringae, Pseudomonas fluorescens, Q3K6B0, A4XYW8, Pseudomonas savastanoi, A4VQZ0 Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas mendocina, Pseudomonas stutzeri 1284 LSPNGGGEP Bacillus caldotenax, Bacillus subtilis P28760, P54375 P04179 1285 LSQSGETAD Streptococcus agalactiae, Q8DZZ7, Q8E5P8, Q06210 Streptococcus agalactiae, Q8P057, P0DB32, Streptococcus pyogenes, P0DB33, Q99ZD3, Streptococcus pyogenes, Q8DTY0, Q5XBV6 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans, Streptococcus pyogenes 1286 LSQSGETADTL Clostridium perfringens, Clostridium Q8XHZ7, Q97MN6, Q06210 acetobutylicum, Escherichia coli, Q8FBT4, P17169, Escherichia coli, Escherichia coli, Q8XEG2, P44708 Haemophilus influenzae 1287 LSVAVYNHYKR Bifidobacterium longum, Q8G5R1, Q8FN57 O76031 Corynebacterium efficiens 1288 LSVAVYNHYKRI Propionibacterium acnes Q6A7F1 O76031 1289 LTASAGIAPN Stenotrophomonas maltophilia, B4SIF5, B2FLR2 Q9UBT6 Stenotrophomonas maltophilia 1290 LTDYGFEGHP Methylobacterium sp., B0ULK6, B1LUN5, O75489 Methylobacterium radiotolerans, B1ZA44, A9W1N1, Methylobacterium populi, Q98KQ7 Methylobacterium extorquens, Rhizobium loti 1291 LTIRLALGG Pseudomonas fluorescens, C3K1H1, Q4KHQ8, Q9Y3D3 Pseudomonas fluorescens, Q3KHJ4, Q886V2, Pseudomonas fluorescens, Q4ZWY9, Q48LW0 Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi 1292 LTPTRELAVQVK Bacillus subtilis P42305 Q9GZR7 1293 LTPVTLELGGKSP Pseudomonas aeruginosa Q9I6C8 P51648 1294 LTRLDHNRA Kocuria rhizophila B2GKC8 P40925 1295 LTRLDHNRAK Propionibacterium acnes Q6A6Z5 P40925 1296 LTTGTFLRG Bacillus licheniformis, Rhizobium Q65CN2, Q1MA19, Q9Y2Z2 leguminosarum, Rhizobium etli Q2K2S1 1297 LTYPLIGNYGI Bacillus subtilis, Bacillus halodurans, P25993, Q9K9V8, P27708 Fusobacterium nucleatum Q8RG87 1298 LVDDSIVRG Pseudomonas aeruginosa, Q51342, P99164, Q06203 Staphylococcus aureus, P65831, Q8NX91, Staphylococcus aureus, Q5HH14, Q6GAE3, Staphylococcus aureus, Q6GI14 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1299 LVDGKDVMP Rhizobium leguminosarum, Q1MM06, Q92SC4 P06744 Rhizobium meliloti 1300 LVDGKDVMPEVN Haemophilus influenzae, Q4QL07, A5UCG6, P06744 Haemophilus influenzae, A5UED2, P44312 Haemophilus influenzae, Haemophilus influenzae 1301 LVEFMASGP Streptomyces avermitilis Q82CA0 O75414 1302 LVEVNCETDFV Neisseria meningitidis, Neisseria A1KWH7, A9M490, P43897 meningitidis, Neisseria meningitidis, P64051, P64050, Neisseria meningitidis, Neisseria Q5F5F4 gonorrhoeae 1303 LVEVNCETDFVS Ralstonia pickettii B2UB07 P43897 1304 LVGDVDFEGV Methylobacterium extorquens Q9X7F6 P13995 1305 LVGGASLKP Clostridium phytofermentans A9KPF8 P60174 1306 LVGGFGLCGIPE Helicobacter pylori, Helicobacter Q9ZLE3, P56006 P55809 pylori 1307 LVGGSTRIP Enterococcus faecalis, Listeria Q835R7, A0AIS4, P48723 welshimeri, Listeria monocytogenes, B8DE38, P0DJM2, Listeria monocytogenes, Listeria G2K046, Q71ZJ7, monocytogenes, Listeria C1KVC0, Q92BN8, monocytogenes, Listeria O06942, B2IMB5, monocytogenes, Listeria innocua, C1CQ18, C1CJ06, Streptococcus mutans, Streptococcus Q8CVVT3, B1IA52, pneumoniae, Streptococcus C1C5N7, Q04LY0, pneumoniae, Streptococcus Q03MR6, Q5M1T8, pneumoniae, Streptococcus C1CCQ8, P95829, pneumoniae, Streptococcus B8ZLY9, Q5M6D1, pneumoniae, Streptococcus C0ME86, C0M7T9 pneumoniae, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus thermophilus, Streptococcus equi, Streptococcus equi 1308 LVIFPEGTR Helicobacter pylori, Helicobacter O25903, Q9ZJN8 Q9NUQ2 pylori 1309 LVLEVAQHLGE Geobacter lovleyi, Geobacter B3EA01, Q74GY0, P06576 sulfurreducens, Geobacter daltonii, B9LZ84, Q39Q56, Geobacter metallireducens, C6E9F1, B5EFI7, Geobacter sp., Geobacter A5G9D8 bemidjiensis, Geobacter uraniireducens 1310 LVLTHFSQRY Streptomyces avermitilis, Q82BX8, Q9RDE4, Q9H777 Streptomyces coelicolor, B1VY42 Streptomyces griseus 1311 LVLTKPLGT Geobacter sulfurreducens Q74FK1 P49903 1312 LVLTPTRELA Haemophilus influenzae P44701 Q9GZR7 1313 LVLTPTRELAVQV Bacillus cereus Q81412 Q9GZR7 K 1314 LVNIFGGIV Aeromonas salmonicida, Aeromonas A4SND2, A0KJK9, Q96I99 hydrophila, Edwardsiella ictaluri, C5BEM7, A4W879, Enterobacter sp., Escherichia coli, B7M5P1, B6I7Z9, Escherichia coli, Escherichia coli, B7N9W6, B1LLG1, Escherichia coli, Escherichia coli, P0A837, P0A836, Escherichia coli, Escherichia coli, B1IY02, A7ZXY8, Escherichia coli, Escherichia coli, B1X6Q8, C4ZWK2, Escherichia coli, Escherichia coli, P0A838, B7NMS9, Escherichia coli, Escherichia coli, B5YQR7, B7LAD4, Escherichia coli, Escherichia coli, A7ZJA8, Q0I3A8, Haemophilus somnus, Klebsiella A6T6F6, B5XZD1, pneumoniae, Klebsiella pneumoniae, B4ESR1, A4XV90, Proteus mirabilis, Pseudomonas A4VKQ1 mendocina, Pseudomonas stutzeri 1315 LVPIGRGQREL Lactobacillus salivarius, Lactobacillus Q1WUC8, Q04BA5, P25705 delbrueckii, Lactobacillus delbrueckii, Q1GAW7, Q831A3, Enterococcus faecalis, Enterococcus P26679, P95787 hirae, Streptococcus mutans 1316 LVPIGRGQRELIIG Helicobacter pylori, Helicobacter P55987, B6JMX4, P25705 D pylori, Helicobacter pylori, B5Z8D2, B2UUP2, Helicobacter pylori, Helicobacter Q17Y80, Q1CSD3, acinonychis, Helicobacter pylori, Q9ZK79 Helicobacter pylori 1317 LVPIGRGQRELIIG Lactobacillus plantarum, Lactobacillus Q88UU1, B2G689, P25705 DR reuteri, Lactobacillus reuteri, A5VIQ9, Q38WK3, Lactobacillus sakei, Lactobacillus Q03A20, B3WDL6, casei, Lactobacillus casei, B2GAU3, Q042L3, Lactobacillus fermentum, Q74K17, A8YUJ9, Lactobacillus gasseri, Lactobacillus Q5FKY2, Q0Q0Y6, johnsonii, Lactobacillus helveticus, Q03V27, B1MW87, Lactobacillus acidophilus, Q03EL2 Lactobacillus brevis, Leuconostoc mesenteroides, Leuconostoc citreum, Pediococcus ntosaceus 1318 LVPIGRGQRELIIG Arcobacter butzleri, Bacillus A8EV72, A7GV58, P25705 DRQTGKT cytotoxicus, Bacillus cereus, Bacillus C1F0N0, Q6HAX7, thuringiensis, Bacillus cereus, Bacillus B9IRT9, B7HY67, cereus, Bacillus cereus, Bacillus Q72XE6, Q630U1, cereus, Bacillus cereus, Bacillus B7JGN2, C3LFI1, anthracis, Bacillus anthracis, Bacillus Q81JZ3, A0RL97, thuringiensis, Bacillus anthracis, C3P1F6, Q814W0, Bacillus cereus, Bacillus A9VSA5, B7IQW0, weihenstephanensis, Bacillus cereus, B7HFK4, A7ZC35, Bacillus cereus, Campylobacter A0RR28, A7H019, concisus, Campylobacter fetus, A8FJR0, Q5HX61, Campylobacter curvus, Q9PJ21, A7I175, Campylobacter jejuni, Campylobacter A1VXI8, A7H1H9, jejuni, Campylobacter jejuni, B9KES1, Q7VJ23, Campylobacter hominis, Q8CNJ5, Q5HMB7, Campylobacter jejuni, Campylobacter Q4L7Y6, A5IUQ0, jejuni, Campylobacter lar, P63675, A7X4U5, Helicobacter hepaticus, P99111, P63676, Staphylococcus epidermidis, A8YY72, Q6G7K5, Staphylococcus epidermidis, Q6GEX0, Q2FF22, Staphylococcus haemolyticus, A6U3J0, Q2FWE8, Staphylococcus aureus, Q2YUJ9, Q5HE95, Staphylococcus aureus, A6QIU9, Q49Z52, Staphylococcus aureus, C1CLK8, B5E673, Staphylococcus aureus, C1CF95, B8ZLB1, Staphylococcus aureus, B2IQX2, C1C8A1, Staphylococcus aureus, Q7CRB1, Q97PT4, Staphylococcus aureus, C1CSD0, B1ICT1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1319 LVPIGRGQRELIIG Bacillus megaterium, Bacillus sp., P17674, P09219, P25705 DRQTGKTS Listeria monocytogenes, Listeria Q71WP7, Q8Y4CO3 monocytogenes, Listeria innocua, Q927W2, A0ALL5, Listeria welshimeri, Streptococcus Q5M106, Q03LX5, thermophilus, Streptococcus Q5M5J3, Q8E5V0, thermophilus, Streptococcus Q8E074, Q3K1J7, thermophilus, Streptococcus B9DRT4 agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus uberis 1320 LVQLPLPEH Pseudomonas mendocina A4XTZ3 P13995 1321 LVQLPLPEHI Haemophilus ducreyi Q7VM86 P13995 1322 LVQLPLPEHID Streptococcus sanguinis A3CLQ4 P13995 1323 LVSGGTDNHLVLV Campylobacter fetus A0RQ16 P34897 1324 LVTGGAGFI Escherichia coli, Escherichia coli, P55293, P37759, O95455 Escherichia coli, Neisseria Q6E7F4, P55294, meningitidis, Neisseria meningitidis, Q9S642, P37761, Neisseria gonorrhoeae, Rhizobium P55462, Q9L9E8 sp., Streptomyces niveus 1325 LVTGGAGYIGSHT Bacillus subtilis P55180 Q14376 1326 LVTGGAGYIGSHT Haemophilus influenzae P24325 Q14376 V 1327 LVTGGAGYIGSHT Bacillus halodurans Q9KDV3 Q14376 VL 1328 LWIDSVAA Desulfovibrio vulgaris, Desulfovibrio A1VEQ5, P62214, Q43542 vulgaris, Streptococcus uberis, B9DW65, P49986 Streptococcus gordonii 1329 LWDAIVIGAG Rhizobium meliloti Q92XP4 Q9P0Z9 1330 LWEAQFGDF Bacillus halodurans, Bacillus clausii Q9KAT1, Q5WG56 Q96HY7 1331 LYAEQLSGS Rhizobium leguminosarum, QIM152, Q2K9E5, Q93099 Rhizobium etli, Rhizobium B5ZZA8, B3PWZ9, leguminosarum, Rhizobium etli, Q9X4F5, C3M930, Rhizobium meliloti, Rhizobium sp., Q983J4 Rhizobium loti 1332 LYAEQLSGSAFT Streptomyces avermitilis Q828S5 Q93099 1333 LYDTYGFPV Streptococcus pneumoniae, B2IQK0, Q8DPC7, P49588 Streptococcus pneumoniae, Q04JW5, Q97Q48, Streptococcus pneumoniae, B1ICI3, Q8CVVY0, Streptococcus pneumoniae, A8AYI8, Q03LZ8, Streptococcus pneumoniae, Q99Z57, P0DG25, Streptococcus mutans, Streptococcus P0DG24, Q5M5L5, gordonii, Streptococcus thermophilus, Q5M126, Q1JG77, Streptococcus pyogenes, Q8E600, Q48SS4, Streptococcus pyogenes, Q1JL53, Q1JB08, Streptococcus pyogenes, Q5XBH1, Q1J5Z4, Streptococcus thermophilus, Q8E0C4, Q8P0E6, Streptococcus thermophilus, Q3K1P7, A2RDY3 Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pyogenes 1334 LYMTRIQKERF Clostridium botulinum, Clostridium B2TNG3, B2UW93 P27708 botulinurn 1335 LYVRRVFITD Geobacter metallireducens Q39SQ3 P14625 1336 LYWLSGLTC Escherichia coli, Escherichia coli, Q1R9R8, A1AD14, P10768 Escherichia coli, Escherichia coli, B1IY65, P33018, Escherichia coli, Escherichia coli, A8A215, B1X7P2, Escherichia coli, Escherichia coli, Q8FFU3, Q0TFT6, Escherichia coli, Escherichia coli, Q8X635, A7ZNX7, Escherichia coli, Escherichia coli, Q8FKG2, B1LKQ1, Escherichia coli, Escherichia coli, Q0TKS8, Q1RFI8, Escherichia coli, Escherichia coli, A1A834, A7ZIA3, Escherichia coli, Escherichia coli, A7ZX03, B1LIP0, Escherichia coli, Escherichia coli, Q8X5J5, B1J086, Escherichia coli, Escherichia coli B1XEU8, P51025 1337 MALPPCHAL Bifidobacterium longum, Neisseria Q8G3T9, A1KVB3, P04818 meningitidis, Neisseria meningitidis, Q9JY72, Q9JT57, Neisseria meningitidis, Neisseria Q5F732, B7V2Q5, gonorrhoeae, Pseudomonas Q02U73, Q9I6F1, aeruginosa, Pseudomonas A6UYE6, A4Y044, aeruginosa, Pseudomonas A4VGL9 aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas stutzeri 1338 MAQIGCFVP Bacillus cytotoxicus, Bacillus subtilis, A7GR99, P49849, P43246 Lactobacillus reuteri, Lactobacillus B2G6E5, A5VIW9, reuteri, Bacillus methylotrophicus, A7Z4X5, Q04505, Lactobacillus gasseri, Lactobacillus Q88UZ7, Q82ZA2 plantarum, Enterococcus faecalis 1339 MASGPVVAMV Streptomyces coelicolor P50589 Q13232 1340 MEALNVLPP Bacteroides vulgatus, Bacteroides A6KZ38, Q64ZY1, P49589 fragilis, Bacteroides fragilis Q5LIT7 1341 MGCSNPHPH Escherichia coli P09148 P07902 1342 MGGQTALNC Escherichia coli, Escherichia coli, Q8FLB0, P63737, P31327 Escherichia coli, Haemophilus P00968, Q7VP67, ducreyi, Neisseria meningitidis, Q9JXW8, Q9JW02, Neisseria meningitidis, Pseudomonas P38100, Q87WP4, aeruginosa, Pseudomonas syringae, Q88DU6, Q8XZ83 Pseudomonas putida, Ralstonia solanacearum 1343 MGHGDEIVL Haemophilus parasuis B8F6Y2 A2VDF0 1344 MGHGDEIVLAD Haemophilus influenzae, Q4QMI4, A5UAS6, A2VDF0 Haemophilus influenzae, P44778, A5UHL6 Haemophilus influenzae, Haemophilus influenzae 1345 MGHVDHGKT Desulfitobacterium hafniense, Q24UI6, A1A0A2, P46199 Bifidobacterium adolescentis, Q8G3Y5, B3DQF0, Bifidobacterium longum, B7GNA3, C4Z5N7, Bifidobacterium longum, B8DW43, Q6A7M5, Bifidobacterium longum, Eubacterium A6L030, Q8A2A1, eligens, Bifidobacterium animalis, A6LHS1, Q64ZR4, Propionibacterium acnes, Bacteroides Q5LIN1, A7GG06, vulgatus, Bacteroides B1I149, C3L0B6, thetaiotaomicron, Parabacteroides A5I4J3, A7FVZ3, distasonis, Bacteroides fragilis, C1FS59, B1KWK7, Bacteroides fragilis, Clostridium A5N842, B2TJ55, botulinum, Clostridium botulinum, Q895J8, Q0SSD4, Clostridium botulinum, Clostridium Q8XJR8, Q0TPR7, botulinum, Clostridium botulinum, A0Q0Q7, B2V4G9, Clostridium botulinum, Clostridium A6LSQ4, Q97I51, botulinum, Clostridium kluyveri, B8I6E7, Q18BH4, Clostridium botulinum, Clostridium Q6NGN2, Q8FPA7, tetani, Clostridium perfringens, B2GKR5, A9M1D5, Clostridium perfringens, Clostridium A1KV51, Q9JYD2, perfringens, Clostridium novyi, Q9JTB5, B4RMZ3, Clostridium botulinum, Clostridium Q5F797, Q7MXE4, beijerinckii, Clostridium B2RHM9, A4XYE0, acetobutylicum, Clostridium A6VCK1, Q9HV55, cellulolyticum, ptoclostridium difficile, B7V1F6, Q02FS8, Corynebacterium diphtheriae, Q3KI84, Q4KIF6, Corynebacterium efficiens, Kocuria A4VPP0, C3K259, rhizophila, Neisseria meningitidis, Q1IF43, B0KHX8, Neisseria meningitidis, Neisseria A5W987, Q88DV7, meningitidis, Neisseria meningitidis, Q4ZNR2, Q87WQ5, Neisseria gonorrhoeae, Neisseria Q48E77, B1J2A9, gonorrhoeae, Porphyromonas B2UAA3, Q8XZV6, gingivalis, Porphyromonas gingivalis, B1VYN5, Q82K53, Pseudomonas mendocina, Q8CJQ8 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas stutzeri, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi, Pseudomonas putida, Ralstonia pickettii, Ralstonia solanacearum, Streptomyces griseus, Streptomyces avermitilis, Streptomyces coelicolor 1346 MGHVDHGKTTLL Lactobacillus reuteri, Lactobacillus B2G6V6, A5VJE0 P46199 DK reuteri 1347 MGKIDKKAL Streptomyces carzinostaticus Q84HC5 Q4G176 1348 MGPLGSPLS Streptomyces coelicolor Q93JL5 P35558 1349 MGVSGSGKS Escherichia coli P46859 Q5T6J7 1350 MIRPRGGDF Streptococcus pyogenes Q5XDL5 Q9NTM9 1351 MITASHNPK Staphylococcus epidermidis, Q5HLD2, Q8CN38 Q96G03 Staphylococcus epidermidis 1352 MITGDNPLT Clostridium perfringens Q0TRT3 Q9HD20 1353 MKSVGEVMA Neisseria gonorrhoeae Q59599 P31327 1354 MKSVGEVMAIGRT Campylobacter jejuni, Rhizobium loti, Q9PIL7, Q98I87, P31327 F Rhizobium meliloti Q92PZ4 1355 MKVRGAPAI Bacillus cereus, Bacillus cereus, Q81IK7, Q63GN3, Q9BV20 Bacillus anthracis, Bacillus Q81ZC2, A0R946, thuringiensis, Bacillus A9VRK3, Q6HP54 weihenstephanensis, Bacillus thu ring iensis 1356 MLACARIGA Helicobacter pylori, Helicobacter Q1CUA3, B6JKX8 Q9NUB1 pylori 1357 MLLLDEPTNHLD Escherichia coli, Escherichia coli, P0A9W3, P0A9W4, Q9UG63 Haemophilus influenzae P45127 1358 MLQQTQVATVI Aeromonas hydrophila P46230 Q9UIF7 1359 MLTGESIPV Staphylococcus aureus, Q2YWA3, Q8NUQ9, Q4VNC0 Staphylococcus aureus, Q6G6B7, Q7A3E6, Staphylococcus aureus, Q99R80, A6U4T8, Staphylococcus aureus, A5IVY3, A7X651, Staphylococcus aureus, A8Z3F8, A6QK47, Staphylococcus aureus, Q5HCZ3, Q2FDV0, Staphylococcus aureus, Q2FV64, Q6GDP1, Staphylococcus aureus, Q8CN02, Q5HL56 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1360 MPTGGGKSLCYQ Escherichia coli P15043 P54132 1361 MQEEIFGPV Bacillus subtilis P39634 P30838 1362 MQKEIFEQP Haemophilus ducreyi Q7VKK4 Q06210 1363 MRQAGRYLP Geobacter daltonii, Geobacter B9M7T4, A5GDW7, P06132 uraniireducens, Geobacter sp., C6E7R9, B5E7R1 Geobacter bemidjiensis 1364 MRQAGRYLPE Acinetobacter baylyi, Acinetobacter Q6F9M1, A3M795, P06132 baumannii, Acinetobacter baumannii, B0VBT2, B7GZK6, Acinetobacter baumannii, B7I451, B2HVF8, Acinetobacter baumannii, B0VUQ9, A45J51, Acinetobacter baumannii, A8EVQ3, B9KFM9, Acinetobacter baumannii, Aeromonas A0RQV9, Q5HTL9, salmonicida, Arcobacter butzleri, A8FMU8, A1WOM7, Campylobacter lari, Campylobacter Q9PN54, A7H2D8, fetus, Campylobacter jejuni, A7ZEJ7, A7I2S8, Campylobacter jejuni, Campylobacter A7GZU8, A8AKS6, jejuni, Campylobacter jejuni, C5BHE8, A4W5C0, Campylobacter jejuni, Campylobacter B7N2J9, Q1R5W3, concisus, Campylobacter hominis, Q8FB74, A1AIG8, Campylobacter curvus, Citrobacter B7UPF2, B7MIY3, koseri, Edwardsiella ictaluri, B7NRT0, B6I5K8, Enterobacter sp., Escherichia coli, B1LNU9, B7NFT8, Escherichia coli, Escherichia coli, P29680, B1IUQ0, Escherichia coli, Escherichia coli, A8A797, C5A0T8, Escherichia coli, Escherichia coli, B1XC00, B7M7Q6, Escherichia coli, Escherichia coli, A7ZUL3, B5Z093, Escherichia coli, Escherichia coli, Q8X6X5, Q0TA68, Escherichia coli, Escherichia coli, B7LA91, B7LUK5, Escherichia coli, Escherichia coli, Q39Z08, Q746R5, Escherichia coli, Escherichia coli, B3EAR8, Q0I5E2, Escherichia coli, Escherichia coli, A6TGQ4, B5XYE1, Escherichia coli, Escherichia coli, B4EYT8, Q87V23, Escherichia fergusonii, Geobacter Q48PG2, Q4ZZD8, metallireducens, Geobacter B1J2J9, Q88CV6, sulfurreducens, Geobacter lovleyi, B0KN28, Q1IGA3, Haemophilus somnus, Klebsiella A5WAA7, Q3KJ97, pneumoniae, Klebsiella pneumoniae, Q4KJI4, C3KBH3, Proteus mirabilis, Pseudomonas B7V3C7, A6VDF5, syringae, Pseudomonas savastanoi, P95458, Q02EY3, Pseudomonas syringae, A4XPQ6, B2UGT5, Pseudomonas putida, Pseudomonas Q8XU90, Q1MA15, putida, Pseudomonas putida, C3MB70, Q98DY6, Pseudomonas entomophila, A5VA70 Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Ralstonia pickettii, Ralstonia solanacearum, Rhizobium leguminosarum, Rhizobium sp., Rhizobium loti, Sphingomonas wittichii 1365 MRVDFNVPMK Fusobacterium nucleatum Q8RFN7 P07205 1366 MTFGLACCA Rhizobium etli Q2K755 O75251 1367 MTFGLACCAVEM Rhizobium loti, Sphingomonas Q98KQ6, A5VAL8 O75251 wittichii 1368 MTFGLACCAVEM Methylobacterium sp., B0ULK5, B8IUU7, O75251 M Methylobacterium nodulans, B7K065, B1LUN6, Methylobacterium extorquens, A9Q1N2, B1ZA45, Methylobacterium radiotolerans, O68853, B5ZYL3, Methylobacterium extorquens, Q1MIL4, Q2K9T4, Methylobacterium populi, Rhizobium B3PVZ8 meliloti, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli 1369 MTVEPGFGGQ Streptomyces coelicolor Q9L0Z5 Q96AT9 1370 MVYVRGHAED Rhizobium etli, Rhizobium Q2KB43, B5ZUG2, Q8NE62 leguminosarum, Rhizobium Q1MJU4, C3MIE4, leguminosarum, Rhizobium sp., B3PTE0 Rhizobium etli 1371 MYCTGGIRCE Citrobacter koseri, Enterobacter sp., A8A124, A4W968, Q5T7W7 Escherichia fergusonii, Escherichia B7LT80, B5YVS5, coli, Escherichia coli, Escherichia coli, Q8X8P2, Q8FIR7, Escherichia coli, Escherichia coli, Q0TJ18, B1IV47, Escherichia coli, Escherichia coli, A7ZZ13, P24188, Escherichia coli, Escherichia coli, B1X9G8, C4ZRZ5, Escherichia coli, Escherichia coli, B7M930, B7NL80, Escherichia coli, Escherichia coli, B7LFG6, A7ZKF9, Escherichia coli, Escherichia coli, B1LIV6, A1A9V1, Escherichia coli, Escherichia coli, B7MIJ6, B6I9D2, Escherichia coli, Escherichia coli, B7NAT1, B7MTI7, Escherichia coli, Klebsiella B7UP69, B5XXK0, pneumoniae, Rhizobium B5ZQU6, Q2K443, leguminosarum, Rhizobium etli, Q1MBM8, Q92LX6, Rhizobium leguminosarum, C3M8W9 Rhizobium meliloti, Rhizobium sp. 1372 MYGQMTAGS Acinetobacter baumannii, B2I2C4, B0V9X6, Q96N76 Acinetobacter baumannii, B7I271, B7GUU5, Acinetobacter baumannii, B0VPV2, Q9KBE5, Acinetobacter baumannii, A9VPT7, A7GQZ9, Acinetobacter baumannii, Bacillus B7J179, Q81Y46, halodurans, Bacillus C3L983, C3P4M1, weihenstephanensis, Bacillus Q637H9, C1EN92, cytotoxicus, Bacillus cereus, Bacillus A0RH38, B7ISJ1, anthracis, Bacillus anthracis, Bacillus B7HCC9, Q733H9, anthracis, Bacillus cereus, Bacillus Q6HFF0, B9IUG9, cereus, Bacillus thuringiensis, Bacillus B7HKJ0, Q81AC7, cereus, Bacillus cereus, Bacillus A7ZAE5, P25503, cereus, Bacillus thuringiensis, Bacillus A8AJ16, A4W8B4, cereus, Bacillus cereus, Bacillus A6T6L0, B5XZ80, cereus, Bacillus methylotrophicus, B8II06, C3K803, Bacillus subtilis, Citrobacter koseri, B1J2Q5, Q9HU83, Enterobacter sp., Klebsiella B7V3J3, Q02ER6, pneumoniae, Klebsiella pneumoniae, Q88CZ6, A5WA67, Methylobacterium nodulans, Q1I3Q8, B0KM58, Pseudomonas fluorescens, A6VDL7, Q87UM6, Pseudomonas putida, Pseudomonas Q4ZLW7, P25080, aeruginosa, Pseudomonas Q48CE0, Q9AGU4, aeruginosa, Pseudomonas Q8XW28, Q92V80, aeruginosa, Pseudomonas putida, Q983H8, A5VFA2, Pseudomonas putida, Pseudomonas P67418, Q6G6Y9, entomophila, Pseudomonas putida, Q5HDM6, P67417, Pseudomonas aeruginosa, Q6GEA4, Q931G1, Pseudomonas syringae, Q49ZQ7, B4SP57, Pseudomonas syringae, B2FKG1 Pseudomonas putida, Pseudomonas savastanoi, Pseudomonas syringae, Ralstonia solanacearum, Rhizobium meliloti, Rhizobium loti, Sphingomonas wittichii, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1373 MYTSGSTGRPKG Bacillus subtilis O31827 O60488 VM 1374 NANGVDLNRNFP Escherichia coli, Escherichia coli P0ACV6, P0ACV7 P15169 1375 NASGINDGAA ptoclostridium difficile, Q18AR0, Q5HIU0, Q9BWD1 Staphylococcus aureus, Q2YVF5, Q2FJQ9, Staphylococcus aureus, Q2G124, Q6GJW4, Staphylococcus aureus, Q8NY95, Q6GCB8, Staphylococcus aureus, Q99WM3, Q7A7L2 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1376 NASGINDGAAA Haemophilus influenzae, P44873, Q8CQN7, Q9BWD1 Staphylococcus epidermidis, Q5HS07 Staphylococcus epidermidis 1377 NASGINDGAAAV Acinetobacter baylyi, Acinetobacter Q43974, Q43935 Q9BWD1 baylyi 1378 NASRTMLFNIH Lactobacillus salivarius, Lactobacillus Q1WVJ0, Q88ZF1, Q14409 plantarum, Clostridium tetani Q891B8 1379 NASTRFSDG Eubacterium rectale, Eubacterium C4Z9V4, C4Z075, P54886 eligens, Helicobacter hepaticus Q7VI05 1380 NCETDFVSRN Ralstonia solanacearum Q8XZJ0 P43897 1381 NCNPETVSTD Helicobacter pylori, Helicobacter Q9ZKT2, O25577 P31327 pylori 1382 NDAFGTAHR Lactobacillus fermentum B2GAL8 P07205 1383 NDAFGTAHRAH Leuconostoc mesenteroides, Q03UX8, B1MW69 P07205 Leuconostoc citreum 1384 NDNLMELLIMI Lactobacillus plantarum, Clostridium Q88Z84, Q899I8, P11908 tetani, Enterococcus faecalis Q82ZA5 1385 NERLEFLGD Clostridium botulinum, Clostridium B2V4D6, B2TJ22, Q9NRR4 botulinum, Clostridium beijerinckii, A6LSM2, Q895M9, Clostridium tetani, Clostridium Q8XJN8, Q6NGH3, perfringens, Corynebacterium B8F3C7, Q7VL75, diphtheriae, Haemophilus parasuis, Q82JT9, Q9ZBQ7 Haemophilus ducreyi, Streptomyces avermitilis, Streptomyces coelicolor 1386 NERLEFLGDA Bacteroides thetaiotaomicron Q8A2E8 Q9NRR4 1387 NERLEFLGDAV Arcobacter butzleri, Bacillus A8EV88, A7Z4L3, Q9NRR4 methylotrophicus, Bacillus Q65JQ5, P51833, licheniformis, Bacillus subtilis, Bacillus A9VT87, Q9KA05, weihenstephanensis, Bacillus Q819V8, B7IUK8, halodurans, Bacillus cereus, Bacillus B7HDX2, Q6HEW6, cereus, Bacillus cereus, Bacillus C1EP73, C3P5Q0, thuringiensis, Bacillus cereus, Bacillus B7JJT6, Q81WI8, anthracis, Bacillus cereus, Bacillus C3L778, B9IVD8, anthracis, Bacillus anthracis, Bacillus B7HLI2, Q732M1, cereus, Bacillus cereus, Bacillus Q636H7, A7GRH9, cereus, Bacillus cereus, Bacillus Q38XR8, Q5WFM6, cytotoxicus, Lactobacillus sakei, Q9PM40, A8FNU7, Bacillus clausii, Campylobacter jejuni, A7H5Y2, Q5HSF8, Campylobacter jejuni, Campylobacter A8Z6F6, A0RRM7, jejuni, Campylobacter jejuni, A7H186, Q97IA4, Campylobacter concisus, Q4JUY7, Q8FP16, Campylobacter fetus, Campylobacter Q8NNV6, Q82ZG1, curvus, Clostridium acetobutylicum, B6JLQ0, Q7VIA9, Corynebacterium jeikeium, Q9ZLH2, P56118, Corynebacterium efficiens, B5Z735, Q17XJ6, Corynebacterium glutamicum, B2UTG4, Q8Y691, Enterococcus faecalis, Helicobacter A0AJR0, B8DDU8, pylori, Helicobacter hepaticus, Q71YL2, ClKWA4, Helicobacter pylori, Helicobacter Q92AK3 pylori, Helicobacter pylori, Helicobacter acinonychis, Helicobacter pylori, Listeria monocytogenes, Listeria welshimeri, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria innocua 1388 NEWDPLEEV Streptomyces griseus P29780 P50440 1389 NEWDPLEEVIVG Streptomyces griseus P08078 P50440 1390 NFCANNYLGL Escherichia coli, Escherichia coli P0AB77, P0AB78 O75600 1391 NFGPQHPAAHGV Neisseria gonorrhoeae, Neisseria B4RPI1, Q5F618, O75306 LR gonorrhoeae, Neisseria meningitidis, Q9K1C0, A1KRS5, Neisseria meningitidis, Neisseria A1INN7, A9M3D9, meningitidis, Neisseria meningitidis, A5VAM0 Sphingomonas wittichii 1392 NFGPQHPAAHGV Stenotrophomonas maltophilia, B4SQT3, B2FNX6 O75306 LRL Stenotrophomonas maltophilia 1393 NFGPQHPAAHGV Methylobacterium sp., B0ULK7, B1ZA43, O75306 LRLV Methylobacterium populi, A9W1N0, B1LUN4, Methylobacterium extorquens, Q2K9T1, B5ZYL5, Methylobacterium radiotolerans, B3PW00, Q1MIL2, Rhizobium etli, Rhizobium Q98KQ8, P56907 leguminosarum, Rhizobium etli, Rhizobium leguminosarum, Rhizobium loti, Rhizobium meliloti 1394 NGAFTGEISP Bacillus clausii, Bacillus cytotoxicus, Q5WDK7, A7GUR9, P60174 Bacillus pumilus, Bacillus A8FHJ2, A7Z8Y3, methylotrophicus, Bacillus A9VQ50, Q72XY3, weihenstephanensis, Bacillus cereus, B7JFG5, B7HW54, Bacillus cereus, Bacillus cereus, Q81X76, Q6HBF1, Bacillus anthracis, Bacillus Q631M0, Q4MQ55, thuringiensis, Bacillus cereus, Bacillus P60180, B7HED4, cereus, Bacillus cereus, Bacillus B7IP22 cereus, Bacillus cereus 1395 NGAGKSTLL Geobacter sulfurreducens Q74DN5 Q8WWZ4 1396 NGAGKSTTI Bacillus subtilis P55339 Q8IUA7 1397 NGAGKTTTF Bacillus subtilis, Bacillus C0SPB4, P26946 Q99758 pseudofirmus 1398 NGAGKTTTI Bacillus licheniformis P42332 Q86UK0 1399 NGIVHRDIKP Clostridium acetobutylicum Q97IC2 Q14164 1400 NGKDYYFVTRE Lactobacillus delbrueckii Q1G9H8 Q16774 1401 NGKVALVTGAA Pseudomonas aeruginosa Q51576 P15428 1402 NGLANPRDFL Pseudomonas aeruginosa, Q9X4G0, B7VA96, Q93099 Pseudomonas aeruginosa, Q02LF6, A6V6F5, Pseudomonas aeruginosa, Q4KI35, Q1I500, Pseudomonas aeruginosa, B0KGU6, Q88E47, Pseudomonas fluorescens, Q6EMI9, A5W8Z1, Pseudomonas entomophila, B1J390, Q3KHV3, Pseudomonas putida, Pseudomonas Q48GS7, Q87Z79, putida, Pseudomonas putida, B2UJ73, Q8XRZ0 Pseudomonas putida, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas syringae, Ralstonia pickettii, Ralstonia solanacearum 1403 NGMDVFRVFD Klebsiella pneumoniae P13187 P11498 1404 NGNEIGGGSIRIH Corynebacterium urealyticum, B1VDL1, C3PGN5, Q6PI48 Corynebacterium aurimucosum, Q4JVF2, Q8NQ19, Corynebacterium jeikeium, A4QEL0, Q8FT19, Corynebacterium glutamicum, C5CCH2 Corynebacterium glutamicum, Corynebacterium efficiens, Micrococcus luteus 1405 NHPDLRRIL Geobacter metallireducens, Q39QA9, Q74GA6 O75489 Geobacter sulfurreducens 1406 NHPDLRRILTDYG Neisseria meningitidis, Neisseria Q9K1C1, Q9JX80, O75489 F meningitidis, Neisseria meningitidis, A1KRS4, A9M3E0, Neisseria meningitidis, Neisseria B4RPI2, Q5F617 gonorrhoeae, Neisseria gonorrhoeae 1407 NIGIGGSDLG Campylobacter jejuni, Helicobacter A7H491, Q17W92, P06744 acinonychis, Helicobacter pylori, B2UUS4, Q9ZK49, Helicobacter pylori, Helicobacter Q25781, B6JNO6, pylori, Helicobacter pylori, Q1CSA0, B5Z8G1 Helicobacter pylori, Helicobacter pylori 1408 NIGIGGSDLGP Bifidobacterium longum, Q8G7I6, Q6NIE5, P06744 Corynebacterium diphtheriae, A4QCJ4, Q8NS31, Corynebacterium glutamicum, Q8FR39, C4LHE0, Corynebacterium glutamicum, Q4JX51, Q8XYN9, Corynebacterium efficiens, Q98BV5, B1W0Z7, Corynebacterium kropnstedtii, Q9Z523, Q82M90, Corynebacterium jeikeium, Ralstonia O88015, B1H069 solanacearum, Rhizobium loti, Streptomyces griseus, Streptomyces coelicolor, Streptomyces avermitilis, Streptomyces coelicolor, Uncultured termite 1409 NIIDTPGHVDFT Bacillus pumilus, Bacillus A8F981, Q65PB0, Q96RP9 licheniformis, Bacillus A7Z0N4, P80868, methylotrophicus, Bacillus subtilis, A9VP74, Q814C5, Bacillus weihenstephanensis, Bacillus B7HJ45, A7GK17, cereus, Bacillus cereus, Bacillus C3LJ79, Q63H93, cytotoxicus, Bacillus anthracis, Q6HPR1, C1ET36, Bacillus cereus, Bacillus thuringiensis, Q81VT3, C3P9Q2, Bacillus cereus, Bacillus anthracis, B9IZJ1, B7HQU1, Bacillus anthracis, Bacillus cereus, Q73F99, B7IT16, Bacillus cereus, Bacillus cereus, B7JKB6, B1IGF7, Bacillus cereus, Bacillus cereus, A7GJ77, A5I7K9, Clostridium botulinum, Clostridium A7FZ72, C3KVQ4, botulinum, Clostridium botulinum, B1KSM8, C1FMV4, Clostridium botulinum, Clostridium A6LPQ8, Q0SQE1, botulinum, Clostridium botulinum, Q8XHS1, Q0TMP3, Clostridium botulinum, Clostridium Q8NT19, A4QBG9, beijerinckii, Clostridium perfringens, Q6NJD6, Q92715, Clostridium perfringens, Clostridium A0ALY9, Q8Y421, perfringens, Corynebacterium B8DAY6, C1KZK7, glutamicum, Corynebacterium Q71WB8, B1GZ80 glutamicum, Corynebacterium diphtheriae, Listeria innocua, Listeria welshimeri, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Uncultured termite 1410 NIIDTPGHVDFTIE Streptococcus suis, Streptococcus A4VSN3, A4VYX6, Q96RP9 V suis, Streptococcus agalactiae, Q8E3E7, Q03IS1, Streptococcus thermophilus, Q5M2M6, Q5LY21, Streptococcus thermophilus, Q8DXS7, Q3JZB5, Streptococcus thermophilus, A3CQM2, A8AUR6, Streptococcus agalactiae, C1CIF3, Q8DW4, Streptococcus agalactiae, C1CPE5, B2ISJ9, Streptococcus sanguinis, B8ZKU0, C1CC62, Streptococcus gordonii, P64023, P64022, Streptococcus pneumoniae, B1I8Z9, C1CB46, Streptococcus mutans, Streptococcus B5E6U5, Q04MH7 pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1411 NIIDTPGHVDFTIE Lactobacillus sakei, Lactobacillus Q38UQ9, B3WAM2, Q96RP9 VER casei, Lactobacillus casei, Q034X8, B8IS82, Methylobacterium nodulans, B1ZLK1, Q748Y8, Methylobacterium populi, Geobacter Q9I244, Q88FI4, sulfurreducens, Pseudomonas Q1MIE4, B5ZYT2, aeruginosa, Pseudomonas putida, B3PWR8, Q2K9L9, Rhizobium leguminosarum, C3MAX7, Q920H2 Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli, Rhizobium sp., Rhizobium meliloti 1412 NIRNFSIVAH Methylobacterium extorquens, B7KR78, B1ZC10 Q8N442 Methylobacterium populi 1413 NKEIFLREL Helicobacter pylori, Ralstonia P56116, Q8Y0Q3 P14625 solanacearum 1414 NKEIFLRELISNA Fusobacterium nucleatum Q8RGH4 P14625 1415 NKEIFLRELISNAS Aggregatibacter P54649, A8AJX0, P14625 DA actinomycetemcomitans, Citrobacter Q894P6, Q97E05, koseri, Clostridium tetani, Clostridium A4W7F7, P0A6Z3, acetobutylicum, Enterobacter sp., P0A6Z4, B1IZC1, Escherichia coli, Escherichia coli, Q0TKG8, A7ZXD1, Escherichia coli, Escherichia coli, P0A6Z5, Q1RF62, Escherichia coli, Escherichia coli, A1A8D9, A7ZIN3, Escherichia coli, Escherichia coli, B8F5X3, A5UFQ9, Escherichia coli, Haemophilus Q4QP81, A5UB42, parasuis, Haemophilus influenzae, Q0I2A3, P44516, Haemophilus influenzae, A6T5N6, Q9I3C5, Haemophilus influenzae, A4XV81, A6V7J7, Haemophilus somnus, Haemophilus Q48K64, Q4ZUW2, influenzae, Klebsiella pneumoniae, Q88FB9, Q4KFX8, Pseudomonas aeruginosa, Q883Y9, Q3KFT8, Pseudomonas mendocina, C3K6N7 Pseudomonas aeruginosa, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas fluorescens 1416 NKEIFLRELISNAS Campylobacter hominis, A7I226, A1VYN0, P14625 DALDK Campylobacter jejuni, Campylobacter Q9PHZ3, A8FKU4, jejuni, Campylobacter jejuni, A7H4M0, Q5HVP5 Campylobacter jejuni, Campylobacter jejuni 1417 NKEPGAEEK Streptococcus thermophilus, Q5M6D0, Q5M1T7, P25685 Streptococcus thermophilus, Q8DWH2 Streptococcus mutans 1418 NKYSEGYPG Lactobacillus plantarum Q88UT5 P34896 1419 NLDEFAMGS Lactobacillus fermentum, B2GDS6, B1ZLM1, Q9H0R6 Methylobacterium populi, A9W748, B7KWB0 Methylobacterium extorquens, Methylobacterium extorquens 1420 NLFAIIQGG Helicobacter acinonychis Q17YB5 Q9BXR0 1421 NLGFSPEDR Staphylococcus carnosus, B9DLK2, Q49UM5 O43252 Staphylococcus saprophyticus 1422 NLIGEHTDYN Lactobacillus plantarum, Lactobacillus Q885E8, Q1WUZ4, P51570 salivarius, Lactobacillus casei, O84902, B3W7I5, Lactobacillus casei, Lactobacillus Q03BB8, Q836P0, casei, Enterococcus faecalis, Q49ZK2, Q9RGS1, Staphylococcus saprophyticus, Q8DNK7, Q97NZ6, Staphylococcus carnosus, Q9ZB10, Q5LYY7, Streptococcus pneumoniae, Q03JS8, P96993, Streptococcus pneumoniae, A4VT88, P13227 Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus mutans, Streptococcus suis, Streptomyces lividans 1423 NLMELLIMI Clostridium perfringens, Listeria Q8XHJ4, Q92F68, P11908 innocua, Listeria monocytogenes, Q48793, Q724L4, Listeria monocytogenes, Listeria Q83TK1, Q83YI7 welshimeri, Listeria ivanovii 1424 NLSGGQKQR Lactobacillus delbrueckii Q04BY7 Q92887 1425 NLSPNGGGEP Corynebacterium diphtheriae P42821 P04179 1426 NMILDDGGD Methylobacterium sp., B0UM37, B8IPU4, P23526 Methylobacterium nodulans, B1ZLX0, A9VYP7, Methylobacterium populi, B7KSJ4 Methylobacterium extorquens, Methylobacterium extorquens 1427 NPAFDVTPH Bacillus pumilus A8FCG5 Q9BV20 1428 NPETVSTDF Bacillus cytotoxicus, Bacillus cereus, A7GRL1, B7JJX3, P31327 Bacillus cereus, Bacillus cereus, Q732I3, B7IUP6, Bacillus cereus, Bacillus cereus, B9IVW3, B7HLM0, Bacillus thuringiensis, Bacillus Q6HE58, C3P656, anthracis, Bacillus anthracis, Bacillus Q81WF2, C3L740, anthracis, Bacillus cereus, Bacillus C1EPQ0, A0RHQ8, thuringiensis, Bacillus A9VTC6, Q636E0, weihenstephanensis, Bacillus cereus, Q819S3, B7H6M2, Bacillus cereus, Bacillus cereus, Q9K9V9, Q38X24, Bacillus halodurans, Lactobacillus Q1WVA9, P77886, sakei, Lactobacillus salivarius, Q9RLS9, Q6A914, Lactobacillus plantarum, Lactobacillus Q834E2, Q03WW7, plantarum, Propionibacterium acnes, B1MZ74, Q92AH3, Enterococcus faecalis, Leuconostoc Q71YI1, A0AJU0, mesenteroides, Leuconostoc citreum, Q8Y665, B8DDR7, Listeria innocua, Listeria C1KWD4, Q03HB0, monocytogenes, Listeria welshimeri, Q5M0W9, Q5M5F6, Listeria monocytogenes, Listeria Q03LT8, Q3K150, monocytogenes, Listeria Q8E5F5, Q8DZQ7, monocytogenes, Pediococcus C10EM9, B1I065, ntosaceus, Streptococcus B5E512, C1C7Q3, thermophilus, Streptococcus B8ZJT9, B2IQ67, thermophilus, Streptococcus Q8CVVR0, Q970E4, thermophilus, Streptococcus C1CR31, Q04K48, agalactiae, Streptococcus agalactiae, C1CL09, Q8DUP3, Streptococcus agalactiae, A3CNI5, C0MEH1, Streptococcus pneumoniae, A8AX83, A2RF60, Streptococcus pneumoniae, B5XKW2, Q9A006, Streptococcus pneumoniae, Q5XCR6, P0DA15, Streptococcus pneumoniae, P0DA14, P58941, Streptococcus pneumoniae, C0M756 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus mutans, Streptococcus sanguinis, Streptococcus equi, Streptococcus gordonii, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus equi 1429 NPETVSTDFD Clostridium acetobutylicum, Q97FT3, A6LPD9 P31327 Clostridium beijerinckii 1430 NPFDLTKVWPH Proteus mirabilis P42321 P04040 1431 NPGDGAFYGPK Fusobacterium nucleatum Q8RF56 A2RTX5 1432 NPTYKEVCS Listeria welshimeri, Listeria A0AJW5, Q8Y640, Q9UJ68 monocytogenes, Listeria B8DDP2, Q71YF6, monocytogenes, Listeria C1KWF9, Q92AE8, monocytogenes, Listeria Q8DYH1, Q3K013, monocytogenes, Listeria innocua, Q8E434 Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae 1433 NPVDILTYV Bacillus cereus, Bacillus thuringiensis, Q632G8, Q6HC14, Q9BYZ2 Bacillus anthracis, Bacillus cereus, Q81K80, Q816G3, Bacillus cereus, Bacillus thuringiensis, P62048, Q6HK31, Bacillus cereus, Bacillus cereus, Q63CN1, P62047, Bacillus anthracis, Bacillus cereus, Q81RW4, Q81EP4, Clostridium thermocellum Q8KQC4 1434 NPVPVMKLVEVI Bacillus subtilis P45856 Q16836 1435 NQIVHRDIK Bacillus subtilis O34507 Q99683 1436 NQRETTVIWDK Lactobacillus sakei, Pediococcus Q38XX6, Q03DS8, Q14410 ntosaceus, Staphylococcus Q4L607, P0DA17, haemolyticus, Streptococcus P0DA16, B9DV90 pyogenes, Streptococcus pyogenes, Streptococcus uberis 1437 NQRETTVVW Aeromonas hydrophila, Aeromonas A0KIT3, A4SPA7, Q14409 salmonicida, Clostridium botulinum, C1FUW6, A7GH02, Clostridium botulinum, Clostridium B1IKJ7, C3L254, botulinum, Clostridium botulinum, B1KYK0, A5I5M0, Clostridium botulinum, Clostridium A7FX30, C6E1L8, botulinum, Clostridium botulinum, B5EB79, Q8XUY1 Geobacter sp., Geobacter bemidjiensis, Ralstonia solanacearum 1438 NQRETTVVWD Desulfovibrio alaskensis, Geobacter Q316D5, Q749I1, O14409 sulfurreducens, Geobacter lovleyi, B3E6Z6, Q51390, Pseudomonas aeruginosa, B4SJT3, B2FI02, Stenotrophomonas maltophilia, Q9RJM2, Q826J2 Stenotrophomonas maltophilia, Streptomyces coelicolor, Streptomyces avermitilis 1439 NQRETTVVWDK Acinetobacter baylyi, Bacillus cereus, Q6FDN3, B7IKB1, Q14409 Bacillus cereus, Bacillus cereus, Q81GZ2, B7HG04, Bacillus methylotrophicus, Bacillus A7Z2U3, P18157, subtilis, Bacillus licheniformis, Q65M11, Q88YD9, Lactobacillus plantarum, Lactobacillus Q047N5, B8FXS7, delbrueckii, Desulfitobacterium C4LGQ3, Q8NLP9, hafniense, Corynebacterium A4QHT1, C6C1M7, kropnstedtii, Corynebacterium B8DL62, C4XGV9, glutamicum, Corynebacterium A1VA10, Q726H4, glutamicum, Desulfovibrio salexigens, O34153, O34154, Desulfovibrio vulgaris, Desulfovibrio Q88NX8, Q3K7I5, maeticus, Desulfovibrio vulgaris, A5VZG7, Q4K734, Desulfovibrio vulgaris, Enterococcus Q1IE16, B0KUG0, casseliflavus, Enterococcus faecalis, C3KBM0, O87924, Pseudomonas putida, Pseudomonas A8Z1X0, A6QGJ8, fluorescens, Pseudomonas putida, Q5HGD2, Q2FYZ5, Pseudomonas fluorescens, Q2FHD9, P99113, Pseudomonas entomophila, P63741, A5IS12, Pseudomonas putida, Pseudomonas A6U1B8, A7X1U3, fluorescens, Pseudomonas tolaasii, Q6GHD5, Q2YXR6, Staphylococcus aureus, Q8NWX7, Q6G9R3, Staphylococcus aureus, Q5HPP1, Q8CSS0, Staphylococcus aureus, Q49X93, Q8NZW9, Staphylococcus aureus, Q1J5E4, B5XMM6, Staphylococcus aureus, A2RD27, Q1JFJ5, Staphylococcus aureus, Q1JKK3, Q1JAF2, Staphylococcus aureus, Q99YI7, Q48RX6, Staphylococcus aureus, Q5XAJ9, B5E357, Staphylococcus aureus, Q8E1T0, Q3K3A6, Staphylococcus aureus, Q8E794, C1CNF8, Staphylococcus aureus, B1I9Z6, B8ZQ22, Staphylococcus aureus, C1CUA3, C1CHI6, Staphylococcus aureus, P63743, B2INK5, Staphylococcus aureus, P63742, Q04HZ0, Staphylococcus epidermidis, C1CBG2, A3CPV3, Staphylococcus epidermidis, A8AVX5 Staphylococcus saprophyticus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus gordonii 1440 NRDHRKIGK Acinetobacter baumannii B0VKJ4 A2RTX5 1441 NRKVLADLA Parabacteroides distasonis, A6L955, Q5LEQ3, Q9BYC9 Bacteroides fragilis, Bacteroides Q64VN9, Q7MVQ8 fragilis, Porphyromonas gingivalis 1442 NRLGANSLL Bacillus subtilis P08065 P31040 1443 NRPKALNAL Clostridium acetobutylicum P52046 P30084 1444 NRSASIRIP Escherichia coli, Escherichia coli, P0A9C6, P0A9C7, P15104 Escherichia coli, Haemophilus P0A9C5, P43794, influenzae, Neisseria gonorrhoeae, P25821, P28786, Proteus hauseri, Pseudomonas Q9HU65, Q3V5W6 aeruginosa, Pseudomonas taetrolens 1445 NSAVFPGLQGGP Ralstonia solanacearum, Rhizobium Q8XTQ1, Q9Q0U6, P34896 meliloti, Rhizobium leguminosarum, Q1MIU5, Q983B6, Rhizobium loti, Rhizobium etli, Q2KA25, Q92XS8, Rhizobium meliloti, Sphingomonas A5V5D1, Q5M4W1 wittichii, Streptococcus thermophilus 1446 NSFGFGGTNATL Escherichia coli, Escherichia coli, P0A954, P0A953, Q9NWU1 Haemophilus influenzae, P43710, Q02K94 Pseudomonas aeruginosa 1447 NTARGGLVDE Methylobacterium extorquens Q59516 Q13363 1448 NTDAEGRLIL Desulfovibrio alaskensis, Neisseria Q315M7, Q9JTI8, P28838 meningitidis, Ralstonia pickettii, B2UAK8, Q8XWQ8, Ralstonia solanacearum, B2FMS4, B4SJ73 Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1449 NTDAEGRLILADA Corynebacterium glutamicum, Q8NNJ4, Q8FNP8 P28838 Corynebacterium efficiens 1450 NTDAEGRLVL Acinetobacter baumannii, B0VMG3, B2I1U0, Q8NDH3 Acinetobacter baumannii, A3M1A8, B0VDC8, Acinetobacter baumannii, B71309, B7H1P9, Acinetobacter baumannii, Q6FFD8, C5BBY4, Acinetobacter baumannii, Q7VNH9, B8F6N9, Acinetobacter baumannii, A5UBH1, Q4QJN7, Acinetobacter baylyi, Edwardsiella P45334, Q0I236, ictaluri, Haemophilus ducreyi, A5UFE2, Q7VGF0, Haemophilus parasuis, Haemophilus C3K6G5, B1JBA9, influenzae, Haemophilus influenzae, Q88P73, Q3KHM4, Haemophilus influenzae, B0KQK8, A5VZ69, Haemophilus somnus, Haemophilus Q86436, Q1I5F9, influenzae, Helicobacter hepaticus, Q4ZXH7, B7UVT6, Pseudomonas fluorescens, O68822, A6V0T2, Pseudomonas putida, Pseudomonas Q02RY8, Q887M0, putida, Pseudomonas fluorescens, A4VNZ7, Q1MIZ4, Pseudomonas putida, Pseudomonas B5ZWY7, Q2KA77, putida, Pseudomonas putida, B3PUV3, Q92QY7, Pseudomonas entomophila, C3M9C8, B9DIX2 Pseudomonas syringae, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Pseudomonas stutzeri, Rhizobium leguminosarum, Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli, Rhizobium meliloti, Rhizobium sp., Staphylococcus carnosus 1451 NTDAEGRLVLAD Campylobacter jejuni, Q9PP04, Q6NG90, Q8NDH3 Corynebacterium diphtheriae, Q17W06, B5Z6U1, Helicobacter acinonychis, O25294, B6JLF2, Helicobacter pylori, Helicobacter Q9ZLR1, Q1CTV6, pylori, Helicobacter pylori, B2UTQ8, Q984S1, Helicobacter pylori, Helicobacter Q82AN2, B1VZN5, pylori, Helicobacter pylori, Rhizobium Q9S2Q7 loti, Streptomyces avermitilis, Streptomyces griseus, Streptomyces coelicolor 1452 NTDAEGRLVLADG Bacillus methylotrophicus, Bacillus A7Z8B5, O32106, Q8NDH3 subtilis, Enterobacter sp. A4WDA4 1453 NTDAEGRLVLADG Bacillus pumilus A8FH04 Q8NDH3 V 1454 NTDNMSILGLTIDY Enterobacter sp., Klebsiella A4W9N5, A6TAH1, Q9BVL4 GP pneumoniae, Klebsiella pneumoniae B5XQE2 1455 NTFVAELKG Citrobacter koseri, Enterobacter sp., A8AQC8, A4WF48, P40926 Escherichia coli, Escherichia coli, Q1R6A3, P61889, Escherichia coli, Escherichia coli, P61890, B1XHK9, Escherichia coli, Escherichia coli, A1AGC9, A8A545, Escherichia coli, Escherichia coli, C4ZSX4, B7N0M1, Escherichia coli, Escherichia coli, B5YSW2, P61891, Escherichia coli, Escherichia coli, B7MBZ7, A7ZSD0, Escherichia coli, Escherichia coli, B7UJW8, B7M0U8, Escherichia coli, Escherichia coli, B7LHU4, Q0TCN0, Escherichia coli, Escherichia coli, B1IQP3, B1LGK2, Escherichia coli, Escherichia coli, B7NKU9, B6I1V4, Escherichia fergusonii, Escherichia B7LRL0, B7NDL4, coli, Klebsiella pneumoniae, Klebsiella A6TEQ3, B5XSQ7, pneumoniae, Klebsiella variicola, P61896, P61894, Klebsiella oxytoca, Raoultella P61895 terrigena 1456 NVGKSSIIN Clostridium cellulolyticum B8I8N7 Q9BVP2 1457 NVGKSSIINSL Clostridium perfringens, Clostridium Q8XKK5, Q0TQK6, Q9BVP2 perfringens, Clostridium perfringens Q0ST57 1458 NVGKSSLIN Lactobacillus casei, Lactobacillus B3WE42, Q039K2, Q9NVN8 casei, Lactobacillus acidophilus, Q5FKR5, Q042T8, Lactobacillus gasseri, Lactobacillus A8YUS5, Q38WS0, helveticus, Lactobacillus sakei, Q8RHK1, Q5LDL2, Fusobacterium nucleatum, Q64UN4, A6L4J3, Bacteroides fragilis, Bacteroides Q8A8T4, A5N2K5, fragilis, Bacteroides vulgatus, Q97FU0, C4Z1T3, Bacteroides thetaiotaomicron, Q748I9, B9LZU0, Clostridium kluyveri, Clostridium Q39YG6, A5G964, acetobutylicum, Eubacterium eligens, B3E2D1, Q92SF6 Geobacter sulfurreducens, Geobacter daltonii, Geobacter metallireducens, Geobacter uraniireducens, Geobacter lovleyi, Rhizobium meliloti 1459 NVGKSSLINGL Clostridium phytofermentans A9KHA0 P36915 1460 NVGKSSLINSL Clostridium botulinum, Clostridium B2TPB6, A6LT31, Q9NVN8 beijerinckii, Clostridium botulinum B2UX10 1461 NVGTIGHVDHG Pseudomonas syringae Q889X3 P49411 1462 PAKSGVAGG Corynebacterium glutamicum Q8NMT3 O94925 1463 PAKSGVAGGI Bacillus cytotoxicus, Bacillus A7GKX3, A9VSP6, O94925 weihenstephanensis, Bacillus cereus, Q81I63, C1EWD5, Bacillus cereus, Bacillus cereus, Q73E07, Q81YY0 Bacillus anthracis 1464 PCGACRQVM Bacillus halodurans Q9KD53 P32320 1465 PCGTTIGPI Streptomyces coelicolor, Q9XA76, Q82F74 Q9ULA0 Streptomyces avermitilis 1466 PDGGIARLRV Streptomyces coelicolor, Q9RKU4, Q82LL5 Q8N6M5 Streptomyces avermitilis 1467 PDGGVSRLR Pseudomonas syringae, Q4ZVG8, C3K0A7, Q8N6M5 Pseudomonas fluorescens, Q48KS4, Q87YX4, Pseudomonas savastanoi, Q3KFK9 Pseudomonas syringae, Pseudomonas fluorescens 1468 PDGGVSRLRL Pseudomonas fluorescens, Q4K8H3, A4VP32 Q8N6M5 Pseudomonas stutzeri 1469 PDIVTMAKG Bilophila wadsworthia Q9APM5 Q9BYV1 1470 PDKDVDGFH Citrobacter koseri, Edwardsiella A8AJS4, C5B8V3, P13995 ictaluri, Enterobacter sp., Escherichia A4W7J0, B7LJI7, fergusonii, Escherichia coli, C4ZUX7, P24186, Escherichia coli, Escherichia coli, B1IZ72, B1XGC7, Escherichia coli, Escherichia coli, B7M4N2, B7L7F6, Escherichia coli, Escherichia coli, B6I0H4, A7ZIT8, Escherichia coli, Escherichia coli, B7N983, B1LKE8, Escherichia coli, Escherichia coli, B7NL23, B7MRJ2, Escherichia coli, Escherichia coli, Q1RF04, Q8FK41, Escherichia coli, Escherichia coli, Q0TKB2, Q8XCT6, Escherichia coli, Escherichia coli, B5YPP4, A1A8J4, Escherichia coli, Escherichia coli, A7ZXI3, B7ME52, Escherichia coli, Escherichia coli, B7UKK6, A6T5R4, Klebsiella pneumoniae, Klebsiella B5Y0K4, B4F1G5, pneumoniae, Proteus mirabilis, Q3K9W7, Q02KT7, Pseudomonas fluorescens, Q9I2U6, B7VB83, Pseudomonas aeruginosa, Q4K9J4, Q4ZUA4, Pseudomonas aeruginosa, B1J675, Q1ICB3, Pseudomonas aeruginosa, A5W638, Q88KM5, Pseudomonas fluorescens, Q48KZ8, A6V726, Pseudomonas syringae, B0KJG3, Q4ZVN1, Pseudomonas putida, Pseudomonas Q87YR0, A4VL74, entomophila, Pseudomonas putida, Q2YX11, Q6GI21 Pseudomonas putida, Pseudomonas savastanoi, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas stutzeri, Staphylococcus aureus, Staphylococcus aureus 1471 PDNYKVIFLQGG Streptococcus agalactiae Q8E3Y3 Q9Y617 1472 PEEKRKIIG Campylobacter hominis, A7I131, Q02R52, P49915 Pseudomonas aeruginosa, Q9HXM6, B7UXJ9, Pseudomonas aeruginosa, Q82HM9 Pseudomonas aeruginosa, Streptomyces avermitilis 1473 PEGATPKDGPSA Fusobacterium nucleatum Q8RHK0 P36776 G 1474 PEGLAVSLP Campylobacter jejuni Q9PIN2 Q8N155 1475 PEKDVDGFH Lactobacillus fermentum B2GD67 Q9H903 1476 PERWHAKGAGA Bacillus subtilis P26901 P04040 1477 PFDLTKVWP Neisseria gonorrhoeae Q59602 P04040 1478 PFGGFKMSG Bacillus licheniformis, Bacillus Q65NN2, Q9K9B2, O94788 halodurans, Bacillus subtilis, Bacillus P94391, Q9K5Z5, halodurans, Bacillus pumilus, A8F9T1, A8Z3F5, Staphylococcus aureus, A5IVY0, A6QK44, Staphylococcus aureus, Q6GDP4, P99076, Staphylococcus aureus, A6U4T5, P63939, Staphylococcus aureus, Q5HCZ6, Q2YWA6, Staphylococcus aureus, Q2FV67, Q2FDV3, Staphylococcus aureus, A7X6R7, Q8NUR2, Staphylococcus aureus, Q4A0E7, Q6G6C0, Staphylococcus aureus, Q8CN04, Q5HL59 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1479 PFGGVGASG Acinetobacter baylyi, Citrobacter Q6FCQ0, A8AHD8, P43353 koseri, Enterobacter sp., Escherichia A4W9J7, B7L046, fergusonii, Pseudomonas Q1I6Z5, Q4K837, entomophila, Pseudomonas Q48G19, C3JXY7, fluorescens, Pseudomonas Q885J7, A5W0D5, savastanoi, Pseudomonas Q88EI4, B0KR47, fluorescens, Pseudomonas syringae, Q4ZQH8, Q3K885 Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas fluorescens 1480 PFGGYKKSG Staphylococcus haemolyticus Q4L919 P49189 1481 PFNFPAMIPLWMF Pseudomonas aeruginosa P28810 Q02252 P 1482 PFNIASYALL Porphyromonas gingivalis Q7MTB5 P04818 1483 PFPGPGLAIR Propionibacterium acnes Q6A6X1 P49915 1484 PFPGPGLAIRV Lactobacillus gasseri, Clostridium Q046I2, B9DYY7, P49915 kluyveri, Clostridium kluyveri, A5N5D9, Q8XI46, Clostridium perfringens, Clostridium A6L090, A0Q2S8, beijerinckii, Clostridium novyi, C3KUC5, A5I720, Clostridium botulinum, Clostridium A7FYP0, A7GIN0, botulinum, Clostridium botulinum, B1IFD1, B1L1J7, Clostridium botulinum, Clostridium C1FLV2, C1CF29, botulinum, Clostridium botulinum, B8ZKZ5, B1ICM9, Clostridium botulinum, Streptococcus P64298, C1CQS0, pneumoniae, Streptococcus C1C842, P64297, pneumoniae, Streptococcus B5E5U0, Q04JQ8, pneumoniae, Streptococcus C1CLE8, B2IQR1 pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1485 PFPGPGLAIRVI Lactobacillus delbrueckii, Q1GBU7, Q04CA4 P49915 Lactobacillus delbrueckii 1486 PFRLGLGGPIGSG Escherichia coli P77775 Q9NRG7 1487 PFSMGPLGS Acinetobacter baylyi, Acinetobacter Q6F8P2, B0VSN6, P35558 baumannii, Acinetobacter baumannii, B2HXC1, A3M840, Acinetobacter baumannii, B7GY31, B0VDR1, Acinetobacter baumannii, B7I624 Acinetobacter baumannii, Acinetobacter baumannii 1488 PFSMGPLGSP Ralstonia solanacearum, Ralstonia Q8Y3G3, B2U804 P35558 pickettii 1489 PGAGGTQRL Escherichia coli P76082 P30084 1490 PGAGKGTQA Aeromonas hydrophila, Aeromonas A0KL52, A4SLY1, P54819 salmonicida, Bacillus halodurans, P38372, Q5WLP1, Bacillus clausii, Bacillus cytotoxicus, A7GK41, B7HJ69, Bacillus cereus, Bacillus cereus, Q81J22, B7HQW5, Bacillus cereus, Bacillus cereus, B9IZL5, Q73F75, Bacillus cereus, Bacillus A9VP98, B7IT40, weihenstephanensis, Bacillus cereus, Q81VQ9, Q6HPN7, Bacillus anthracis, Bacillus B7JKE1, C3P9S6, thuringiensis, Bacillus cereus, Bacillus A0R8K1, Q63H69, anthracis, Bacillus thuringiensis, C1ET60, C3LJA3, Bacillus cereus, Bacillus cereus, P35140, A8F9A6, Bacillus anthracis, Bacillus B3WAJ7, B2G8V7, licheniformis, Bacillus pumilus, B2GDU8, C4ZBT9, Lactobacillus casei, Lactobacillus Q8RE31, C4Z2V1, reuteri, Lactobacillus fermentum, Q6A6Q4, A8AJW9, Eubacterium rectale, Fusobacterium A3DJJ3, A9KJH3, nucleatum, Eubacterium eligens, B8I800, C5BD16, Propionibacterium acnes, Citrobacter A4W7F8, Q8FK84, koseri, Clostridium thermocellum, B7NIF6, Q0TKG7, Clostridium phytofermentans, B7UKF4, B7MQI9, Clostridium cellulolyticum, B1IZC0, B6I0Q6, Edwardsiella ictaluri, Enterobacter A7ZIN4, P69441, sp., Escherichia coli, Escherichia coli, B7LV13, P69442, Escherichia coli, Escherichia coli, B1LJN2, A7ZXD2, Escherichia coli, Escherichia coli, B1XFR1, B7N927, Escherichia coli, Escherichia coli, B7L799, C4ZUS8, Escherichia coli, Escherichia B7M3W6, B7MDZ6, fergusonii, Escherichia coli, Q4QNJ1, A5UAD6, Escherichia coli, Escherichia coli, P24323, A5UGF8, Escherichia coli, Escherichia coli, Q7VMY0, Q0I2Y5, Escherichia coli, Escherichia coli, A6T5N7, B5Y0N3, Escherichia coli, Escherichia coli, Q927M8, C1KZF9, Haemophilus influenzae, Q71WG7, A0ALU7, Haemophilus influenzae, Q8Y449, B8DB29, Haemophilus influenzae, E6MY99, P0A0U7, Haemophilus influenzae, A1KT73, P0A0U6, Haemophilus ducreyi, Haemophilus P0DH56, A9M3Q2, somnus, Klebsiella pneumoniae, Q5F9J3, B4RKA2, Klebsiella pneumoniae, Listeria P49979, P49981, innocua, Listeria monocytogenes, B4F1Q2, A4XXP5, Listeria monocytogenes, Listeria B1JD29, B0KS64, welshimeri, Listeria monocytogenes, Q4KHK4, Q9HXV4, Listeria monocytogenes, Neisseria Q02RF8, B7V109, meningitidis, Neisseria meningitidis, A6V1A1, C3KEC6, Neisseria meningitidis, Neisseria A5W880, P0A137, meningitidis, Neisseria meningitidis, P0A136, Q886R8, Neisseria meningitidis, Neisseria Q3KHE3, Q1IDV1, gonorrhoeae, Neisseria gonorrhoeae, Q48F36, Q4ZWV2, Neisseria gonorrhoeae, Neisseria B2UB85, Q8XWE1, mucosa, Proteus mirabilis, Q8CRI0, Q5HM20, Pseudomonas mendocina, Q6G792, P99062, Pseudomonas putida, Pseudomonas P65201, Q5HDX9, putida, Pseudomonas fluorescens, Q6GEK4, P65202, Pseudomonas aeruginosa, A4VYR4, A4VSH4 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas savastanoi, Pseudomonas syringae, Ralstonia pickettii, Ralstonia solanacearum, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus suis, Streptococcus suis 1491 PGCDHAGIATQ Fusobacterium nucleatum Q8RHK3 P26640 1492 PGDGIGPEI Bacillus clausii, Desulfovibrio vulgaris, Q5WEN4, Q726X1, P50213 Pseudomonas aeruginosa, Q51375, Q88LE5, Pseudomonas putida, Pseudomonas Q3KF21, Q4KF05, fluorescens, Pseudomonas Q48K97, Q4ZUZ4, fluorescens, Pseudomonas Q884C0, Q4L7U1, savastanoi, Pseudomonas syringae, Q49Z13, Q5HMF8, Pseudomonas syringae, Q8CNL2, Q2FWK2, Staphylococcus haemolyticus, Q6GF15, Q6G7Q0, Staphylococcus saprophyticus, P65101, P65100, Staphylococcus epidermidis, Q2YUF1, Q5HEE3, Staphylococcus epidermidis, Q2FF66, Q8NVJ0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1493 PGLAHFLEH Pseudomonas syringae, Q88A79, P55174, O43847 Pseudomonas protegens, Q9I2D2, Q88QV3 Pseudomonas aeruginosa, Pseudomonas putida 1494 PGLGKTTLA Desulfovibrio alaskensis, Q30YX7, P61531, Q8WVB6 Desulfovibrio vulgaris, Desulfovibrio A1VC44 vulgaris 1495 PGMVLTVEPG Escherichia coli, Streptomyces P15034, P0A3Z2, P12955 lividans, Streptomyces coelicolor P0A3Z1 1496 PGRVNLIGEH Clostridium tetani Q896X8 P51570 1497 PGRVNLIGEHTDY Fusobacterium nucleatum, Q8RHD0, Q97EZ6, P51570 N Clostridium acetobutylicum, A6M1P8 Clostridium beijerinckii 1498 PGSGKGTQS Parabacteroides distasonis A6LD69 Q9Y6K8 1499 PGSSIMPGKVNP Bacillus subtilis, Helicobacter pylori, P26899, Q9ZLI5, P07954 Helicobacter pylori, Pseudomonas P56149, P07346, fluorescens, Pseudomonas Q51404, Q9HTD7, aeruginosa, Pseudomonas Q9FBN6, Q82ID7 aeruginosa, Streptomyces coelicolor, Streptomyces avermitilis 1500 PGTGKTLLA Akkermansia muciniphila B2UMY1 Q9Y4W6 1501 PGTGKTLLAKA Ralstonia pickettii, Uncultured termite B2UE66, B1GZK7 Q9Y4W6 1502 PGVGQNLQDH Rhizobium meliloti P54223 Q8NE62 1503 PGYTHLQRAQ Clostridium kluyveri, Clostridium B9E0B2, A5N6U3, P04424 kluyveri, Clostridium tetani, P59616, Q182I5 ptoclostridium difficile 1504 PGYTHLQRAQPI Bacillus licheniformis Q65G68 P04424 1505 PHGLGHFLG Aeromonas salmonicida, Aeromonas A4STF0, A0KEL3 P12955 hydrophila 1506 PHLGASTKEAQ Bacillus subtilis P35136 O43175 1507 PHVNVGTIGHVDH Pseudomonas fluorescens, C3K2X8, Q4ZMP2, P49411 G Pseudomonas syringae, Q48D34, Q3K5X4, Pseudomonas savastanoi, B1JDW6, B0KK53, Pseudomonas fluorescens, A5VXN3, Q88QP8, Pseudomonas putida, Pseudomonas Q1IFW8, Q88QN7 putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida 1508 PIFHVNADD Staphylococcus aureus, Q931R8, A5ISU5, Q9ULD0 Staphylococcus aureus, A7X295, A6U1N4, Staphylococcus aureus, Q8NWR6, Q5HG06, Staphylococcus aureus, A8Z3Z0, Q2FH25, Staphylococcus aureus, Q2FYM1, Q6G9E8, Staphylococcus aureus, A6QGW6, Q6GGZ5, Staphylococcus aureus, P0C601, Q99U74, Staphylococcus aureus, Q2YY05 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1509 PIGRGQREL Desulfovibrio alaskensis Q313V8 P25705 1510 PIGRGQRELIIGDR Bacillus clausii, Clostridium kluyveri, Q5WB76, B9DX63, P25705 QTGKT Clostridium kluyveri, Clostridium A5N3H9, A6LQH4, beijerinckii, Desulfovibrio vulgaris, B8DRD0, B8J437, Desulfovibrio desulfuricans, C4XI08 Desulfovibrio maeticus 1511 PIGRGQRELIIGDR Parabacteroides distasonis, A6L8N5, Q64UA4, P25705 QTGKTSIAIDTIINQ Bacteroides fragilis, Bacteroides Q5LD82, Q8A9U7 fragilis, Bacteroides thetaiotaomicron 1512 PIIMVGPGTG Bacillus subtilis, Bacillus subtilis O32214, O08394 Q9UBK8 1513 PILTMPNDDITHPI Clostridium tetani Q891P2 P15313 PDLTG 1514 PISAKLVAN Rhizobium meliloti Q92N73 P11908 1515 PISAKLVANM Rhizobium loti Q98HW3 P11908 1516 PISAKLVANML Neisseria meningitidis, Neisseria P65235, P65234 P11908 meningitidis 1517 PIWEQTGRGER Geobacter metallireducens, Q39UH2, Q74C82, Q16740 Geobacter sulfurreducens, Geobacter B5EI27, B9M0Y1, bemidjiensis, Geobacter daltonii, A5GFA0, C6E2T0 Geobacter uraniireducens, Geobacter sp. 1518 PIVYTPTVG Bacillus subtilis O34389 P48163 1519 PKDKPRYLMGVG Staphylococcus carnosus, B9DNG7, Q2YT91, Q9BXR0 Staphylococcus aureus, A8Z2G7, P66906, Staphylococcus aureus, Q6G8T0, P66905, Staphylococcus aureus, A60HI1, Q6GG65, Staphylococcus aureus, P66904, A5ITG3, Staphylococcus aureus, Q5HFC4, Q2FXT6, Staphylococcus aureus, Q2FG88, A7X354, Staphylococcus aureus, A6U2A7, Q5HNR2, Staphylococcus aureus, Q8CML7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1520 PKGFGGVQVSPP Aeromonas hydrophila P41131 P04746 1521 PKGVLLYGPPG Bifidobacterium animalis, C6A7B2, C6AHX0, Q8NBU5 Bifidobacterium animalis, B8DTX4, D3R4I7 Bifidobacterium animalis, Bifidobacterium animalis 1522 PKILLLDEP Bacillus cereus, Bacillus cereus, O31339, Q81GU1, Q8WWZ7 Pseudomonas aeruginosa Q9I6L0 1523 PLFILYTSGSTGKP Ralstonia pickettii, Ralstonia B2U6V1, Q8XY11 Q9NR19 KGV solanacearum 1524 PLGVCVGIGAWN Rhizobium leguminosarum Q1MJU3 P49189 YP 1525 PLHVCEQRD Bacillus subtilis O06735 O43252 1526 PLIGFAGAP Streptomyces griseus, Streptomyces B1WVH6, Q82KY4, P06132 avermitilis, Streptomyces coelicolor Q69861 1527 PLKGARIAG Corynebacterium glutamicum, A4QQ87, Q8NSC4, P23526 Corynebacterium glutamicum, Q8FRJ4, Q8Y387, Corynebacterium efficiens, Ralstonia B2U774 solanacearum, Ralstonia pickettii 1528 PLRGKILNV Bacillus subtilis, Bacillus halodurans, P05652, O50627, P11388 Campylobacter jejuni, Staphylococcus O87667, P0A0K7, aureus, Staphylococcus aureus, P0A0K8, Q6GD85, Staphylococcus aureus, Q2FKQ1, P66937, Staphylococcus aureus, P66936, Q8CQK4, Staphylococcus aureus, Q5HK03, Q6GKU0, Staphylococcus aureus, Q5HJZ1 Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus aureus 1529 PLSVELGPG Clostridium novyi, Clostridium A0PZC6, B1IJM8, P38606 botulinum, Clostridium botulinum, A7GGL4, B1KXT6, Clostridium botulinum, Clostridium A51557, A7FWQ7, botulinum, Clostridium botulinum, A3DHP0 Clostridium thermocellum 1530 PLTGRTHQIR Helicobacter pylori, Helicobacter Q9ZMA1, QO5114 Q8IZ73 pylori 1531 PLTLGGDHTIT Pseudomonas aeruginosa Q9I3S3 Q9BSE5 1532 PLVVRLEGTNV Bacillus pumilus, Bacillus A8FD73, Q65JP0, Q96199 licheniformis, Bacillus A7Z4M9, P80886 methylotrophicus, Bacillus subtilis 1533 PMGWDAFGLPAE Bacillus licheniformis, Bacillus subtilis, Q65FX8, P36430, Q15031 Bacillus halodurans, Haemophilus Q9K758, Q7VM66, ducreyi, Streptococcus pneumoniae, B2IS10, C1CPD0, Streptococcus pneumoniae, B1I8Y2, C1CID7, Streptococcus pneumoniae, A4VY58, A4W4F3, Streptococcus pneumoniae, C1CC47, Q97SS0, Streptococcus suis, Streptococcus B8ZKS5, Q03MJ2, suis, Streptococcus pneumoniae, Q5M657, Q5M1L6, Streptococcus pneumoniae, B5E6T0, Q8DRB6, Streptococcus pneumoniae, Q04MJ2, C1CB31, Streptococcus thermophilus, P67515, P67514, Streptococcus thermophilus, Q3JYR6, A3CKP1, Streptococcus thermophilus, A8AZ43, B4U0A1, Streptococcus pneumoniae, C0M8N3, Q8P2T2, Streptococcus pneumoniae, Q1JNR2, Q1JDV2, Streptococcus pneumoniae, Q1JIV9, Q8DS85, Streptococcus pneumoniae, Q5XE35, C0MET9, Streptococcus agalactiae, P0DG45, P0DG44, Streptococcus agalactiae, A2RCB2, Q9A1P0, Streptococcus agalactiae, B5XJI9, Q48VJ7, Streptococcus sanguinis, Q1J8Q8 Streptococcus gordonii, Streptococcus equi, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans, Streptococcus pyogenes, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 1534 PMGWDAFGLPAE Clostridium thermocellum, A3DEU0, A1VEL2, Q15031 NAA Desulfovibrio vulgaris, Desulfovibrio Q72CT7, Q30YL0, vulgaris, Desulfovibrio alaskensis, B8DJF0, B2FPR7, Desulfovibrio vulgaris, B4SRE7 Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1535 PNVGKSSFI Geobacter sulfurreducens, Geobacter Q74702, Q39QR4 Q9BZE4 metallireducens 1536 PNVGKSSIIN Clostridium phytofermentans, A9KLK7, C4Z0C8 Q9BVP2 Eubacterium eligens 1537 PNVGKSSLIN Eubacterium rectale, Clostridium C4ZD63, Q895X8, Q9NVN8 tetani, Clostridium botulinum, B2THQ9, Q0SS66, Clostridium perfringens, Clostridium Q8XJK1, Q0TPJ9, perfringens, Clostridium perfringens, B2V3Z1, A5N7W7, Clostridium botulinum, Clostridium B9E1C8, A6LSI6, kluyveri, Clostridium kluyveri, A5I4V0, A7FW89, Clostridium beijerinckii, Clostridium A3DE77, A0Q125, botulinum, Clostridium botulinum, B1KX71, B1IIN2, Clostridium thermocellum, Clostridium C1FSU2, A7GGA7, novyi, Clostridium botulinum, C3L0M1, Q834T4, Clostridium botulinum, Clostridium B051N2, Q9ZLF3, botulinum, Clostridium botulinum, O25396, B9DTQ3 Clostridium botulinum, Enterococcus faecalis, Finegoldia magna, Helicobacter pylori, Helicobacter pylori, Streptococcus uberis 1538 PNVTDIVSIARAA Desulfovibrio maeticus C4XPD6 Q12882 1539 PPKGVLLYGPPG Bifidobacterium dentium, D2Q9C6, A1A0U4, Q8NBU5 Bifidobacterium adolescentis, B7GUP3, B3DRN4, Bifidobacterium longum, Q8G3G6, Q4JVP5, Bifidobacterium longum, B1VDV2 Bifidobacterium longum, Corynebacterium jeikeium, Corynebacterium urealyticum 1540 PPKGVLLYGPPGC Corynebacterium glutamicum, Q8NQD8, A4QE83, Q8NBU5 GKTLIAKA Corynebacterium glutamicum, Q8FTE3, Q6NH92, Corynebacterium efficiens, C9Z319, Q828J2, Corynebacterium diphtheriae, Q9RJ58 Streptomyces scabiei, Streptomyces avermitilis, Streptomyces coelicolor 1541 PPPNVTGSLH Sphingomonas elodea Q7X2N3 P26640 1542 PQDATTNPSLIL Haemophilus somnus, Haemophilus Q01IU0, A5UIP9, P37837 influenzae, Haemophilus influenzae, P45055, A5UCY0, Haemophilus influenzae, Q4QLG9, Q7VP02 Haemophilus influenzae, Haemophilus ducreyi 1543 PQGTLAERIRAGG Bacillus subtilis, Haemophilus O34317, P44875 P55809 AG influenzae 1544 PQILLLDEP Escherichia coli, Escherichia coli, Q8FFB3, Q8XBJ8, Q8N139 Escherichia coli P16676 1545 PQNRVTDHRI Lactobacillus helveticus, Lactobacillus A8YUJ1, Q042K5, Q9UGC7 gasseri, Lactobacillus acidophilus, Q5FKZ0, Q74K25, Lactobacillus johnsonii, Lactobacillus B2GAT1, Q1GAX5, fermentum, Lactobacillus delbrueckii, Q04BB3, Q03QX7, Lactobacillus delbrueckii, Q8Y4A8, B8DBG6, Lactobacillus brevis, Listeria Q71WN5, C1KYW0, monocytogenes, Listeria A0ALM8, Q927V0 monocytogenes, Listeria monocytogenes, Listeria monocytogenes, Listeria welshimeri, Listeria innocua 1546 PRFRGEHALRRY Methylobacterium extorquens, A9W1M5, B1LUM8, O00217 P Methylobacterium radiotolerans, B7KQ58, B1ZA38 Methylobacterium extorquens, Methylobacterium populi 1547 PRNLAKSVTVE Bacillus halodurans, Staphylococcus Q9KG45, Q8CRL1, Q06210 epidermidis, Staphylococcus Q5HM69, Q97SQ9, epidermidis, Streptococcus Q8DRA8, Q86781 pneumoniae, Streptococcus pneumoniae, Streptomyces coelicolor 1548 PSAFDRILASR Clostridium novyi A0PYC8 Q01813 1549 PSGAGKSTL Ralstonia solanacearum Q8XXF9 Q16774 1550 PTGGGKSLCYQL Bacillus subtilis P50729 P54132 P 1551 PTQGMRQGND Pseudomonas savastanoi, Q48CJ2, A4XPS6, Q9UJ68 Pseudomonas mendocina, Q88AI5, B0KJ25, Pseudomonas syringae, Q1I3L0, Q88QZ8, Pseudomonas putida, Pseudomonas B1JE82 entomophila, Pseudomonas putida, Pseudomonas putida 1552 PVDIYIPGC Campylobacter concisus A7ZBE5 O75251 1553 PVDLFPHTPH Desulfovibrio vulgaris Q72DK5 Q96GJ1 1554 PVFGICLGHQLLA Pseudomonas stutzeri P38099 P27708 LA 1555 PVFNTVKEA Methylobacterium extorquens P53595 P53597 1556 PVLGICYGM Ralstonia solanacearum Q8XZG4 P49915 1557 PVLGICYGMQ Bacillus methylotrophicus, Bacillus A7Z235, P29727, P49915 subtilis, Bacillus licheniformis, Bacillus Q65MU0, A8FAH5, pumilus, Campylobacter jejuni, A1W0N3, A7H2D2, Campylobacter jejuni, Campylobacter Q9PN49, A0RQD7, jejuni, Campylobacter fetus, B9KFL4, B8I4P0, Campylobacter lari, Clostridium C6BSD8, A1VEV0, cellulolyticum, Desulfovibrio Q72D86, Q31IX7, salexigens, Desulfovibrio vulgaris, B9M9G4, Q39TA7, Desulfovibrio vulgaris, Desulfovibrio P60500, P44335, alaskensis, Geobacter daltonii, Q0I2D2, Q4QNW4, Geobacter metallireducens, Q7VLE9, B8F3T2, Geobacter sulfurreducens, Q9JXR2, Q5F4X9, Haemophilus influenzae, B4RJH7, A9M138, Haemophilus somnus, Haemophilus B4EY59, B0KRE6, influenzae, Haemophilus ducreyi, Q88P21, A5VZC3, Haemophilus parasuis, Neisseria Q1I5K9, A4XY17, meningitidis, Neisseria gonorrhoeae, Q8CMQ8, Q4L386, Neisseria gonorrhoeae, Neisseria Q5HRX1, Q2YVL5, meningitidis, Proteus mirabilis, Q8NY69, Q6GC81, Pseudomonas putida, Pseudomonas P64296, A5IPX0, putida, Pseudomonas putida, Q6GJQ6, A7WY93, Pseudomonas entomophila, P99105, A6TYP2, Pseudomonas mendocina, B9DLM7, A6QE71, Staphylococcus epidermidis, A8Z0R1, Q5HIQ6, Staphylococcus haemolyticus, Q2G0Y6, Q2FJM5, Staphylococcus epidermidis, Q8DU81 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus carnosus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus mutans 1558 PVTLELGGKSP Acinetobacter sp., Escherichia coli, Q9FDS1, P37685, P51648 Pseudomonas sp., Streptomyces O86447, F8JX40, cattleya, Streptomyces coelicolor Q9RJZ6 1559 PVVAMVWEG Desulfitobacterium hafniense, Q251Q1, B8FZD1 O60361 Desulfitobacterium hafniense 1560 PVVTIMGHVDHGK Acinetobacter baumannii, B0VLU2, B0VE81, P46199 T Acinetobacter baumannii, B2I2M7, B7I3R9, Acinetobacter baumannii, B7H115, Q6FF40, Acinetobacter baumannii, A0KNE3, A4SJR5, Acinetobacter baumannii, B1ZDQ8, Q30WJ0, Acinetobacter baylyi, Aeromonas A1VG83, Q72ER1, hydrophila, Aeromonas salmonicida, B8J1Y4, C5BFB7, Methylobacterium populi, Q9ZF25, A5GF86, Desulfovibrio alaskensis, Q74CT3, B5EI57, Desulfovibrio vulgaris, Desulfovibrio B3EAE7, C6E2Q0, vulgaris, Desulfovibrio desulfuricans, Q39VA6, B9M1G0, Edwardsiella ictaluri, Enterobacter Q4QK37, A5UF34, cloacae, Geobacter uraniireducens, P44323, A5UBT6, Geobacter sulfurreducens, Geobacter Q0I3P5, Q7VLI2, bemidjiensis, Geobacter lovleyi, Q9ZF28, B5XSX4, Geobacter sp., Geobacter A6TEI7, Q2KDZ5, metallireducens, Geobacter daltonii, Q1MN39, B3PXE3, Haemophilus influenzae, Q981318, A5VCZ5, Haemophilus influenzae, B2FN90, B4SQS0 Haemophilus influenzae, Haemophilus influenzae, Haemophilus somnus, Haemophilus ducreyi, Klebsiella oxytoca, Klebsiella pneumoniae, Klebsiella pneumoniae, Rhizobium etli, Rhizobium leguminosarum, Rhizobium etli, Rhizobium loti, Sphingomonas wittichii, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1561 PVVTIMGHVDHG Bacillus halodurans, Bacillus Q9KA77, A7Z4T4, P46199 KTTLLD methylotrophicus, Bacillus subtilis, P17889, A8YVQ7, Lactobacillus helveticus, Bacillus A8FDD1, Q65JI1, pumilus, Bacillus licheniformis, Q5FJN6, Q5WFU2, Lactobacillus acidophilus, Bacillus Q38W81, Q049V5, clausii, Lactobacillus sakei, Q1G9P9, Q04467, Lactobacillus delbrueckii, Q74IS8, Q835U8, Lactobacillus delbrueckii, P18311, B1MZH4, Lactobacillus gasseri, Lactobacillus B8DG02, A0AIC6, johnsonii, Enterococcus faecalis, Q92C29, Q71ZZ7, Enterococcus faecium, Leuconostoc C1L2N1, Q8Y7F6, citreum, Listeria monocytogenes, B8ZM93, B5E266, Listeria welshimeri, Listeria innocua, B2IME4, C1CCT8, Listeria monocytogenes, Listeria Q8DQV2, Q04LW0, monocytogenes, Listeria C1CQ48, C1C5S8, monocytogenes, Streptococcus C1CJ39, Q97S57, pneumoniae, Streptococcus B1IA80 pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1562 PVVTIMGHVDHG Lactobacillus salivarius Q1WUF4 P46199 KTTLLDK 1563 PWGKGRPGWHIE Lactobacillus reuteri, Lactobacillus B2G555, A5VI99, P49589 CS reuteri, Lactobacillus casei, Q035S0, B3WA35, Lactobacillus casei, Lactobacillus Q38UZ6, Q045X8, sakei, Lactobacillus gasseri, A8YTD3, Q74L26, Lactobacillus helveticus, Lactobacillus Q5FM34, Q048S9, johnsonii, Lactobacillus acidophilus, Q1G8Z0, Q97ED6, Lactobacillus delbrueckii, Q839V5, B1MW68, Lactobacillus delbrueckii, Clostridium A4XVG1, Q8E7F2, acetobutylicum, Enterococcus Q8E1Z4, Q3K3G5 faecalis, Leuconostoc citreum, Pseudomonas mendocina, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae 1564 PWGKGRPGWHIE Bacillus subtilis, Bacillus Q06752, A7Z0L6, P49589 CSAM methylotrophicus, Bacillus Q9KGF4, B8G1U2, halodurans, Desulfitobacterium Q250Q6, A5G949, hafniense, Desulfitobacterium B3E1P0, B9LZV4, hafniense, Geobacter uraniireducens, B8F392, B1GYT2 Geobacter lovleyi, Geobacter daltonii, Haemophilus parasuis, Uncultured termite 1565 PWGKGRPGWHIE Bacillus cytotoxicus, Bacillus A7GK01, A9VNA2, P49589 CSAMA weihenstephanensis, Bacillus Q65PC8, A3DH43 licheniformis, Clostridium thermocellum 1566 PWTIPANEA Lactobacillus helveticus, Lactobacillus A8YUP7, Q5FKU5 Q9NSE4 acidophilus 1567 PWTIRQYAGFST Escherichia coli, Streptomyces P27253, Q05065 P22033 cinnamonensis 1568 PWVRNIFIVT Neisseria meningitidis Q51151 Q3T906 1569 PYPSGKLHMGHV Ralstonia solanacearum, Ralstonia Q8XVT3, B2UCA1 Q15031 R pickettii 1570 PYVSGFLAFRE Bacillus methylotrophicus, Bacillus A7Z9I5, P96724 Q8N8Q3 subtilis 1571 QAHGLCFSV Bacteroides vulgatus, Bacteroides A6L7T5, Q64PM3, P13051 fragilis, Bacteroides fragilis, Q5L9D9, Q8A5V6 Bacteroides thetaiotaomicron 1572 QAHGLCFSVQ Pseudomonas aeruginosa, B7UYZ2, A6VAM7, P13051 Pseudomonas aeruginosa, Q9I5H9, Q02HQ1 Pseudomonas aeruginosa, Pseudomonas aeruginosa 1573 QCGTIQLDF Haemophilus parasuis B8F5H9 Q9BW92 1574 QDDAHIFCT Acinetobacter baumannii, B2HTH0, B7H005, A2RTX5 Acinetobacter baumannii, B0V5P2, A3M299, Acinetobacter baumannii, B7I688, A0KKP9, Acinetobacter baumannii, A4SMA4, C5B846, Acinetobacter baumannii, Aeromonas A4W9M3, Q1RB76, hydrophila, Aeromonas salmonicida, B1LE12, B7N556, Edwardsiella ictaluri, Enterobacter P0A8M3, P0A8M4, sp., Escherichia coli, Escherichia coli, Q0THB0, A1ABQ2, Escherichia coli, Escherichia coli, B1XGI1, C4ZYI1, Escherichia coli, Escherichia coli, B7MVJ7, B7NT58, Escherichia coli, Escherichia coli, B7MAS9, B7USA2, Escherichia coli, Escherichia coli, B7LQ71, B5YQ07, Escherichia coli, Escherichia coli, Q8XE27, B7M1C7, Escherichia coli, Escherichia B6IBD7, B1IPK9, fergusonii, Escherichia coli, A8A0R2, B7L6J2, Escherichia coli, Escherichia coli, A7ZMI6, Q7VKR9, Escherichia coli, Escherichia coli, Q0I3M2, A5UBX5, Escherichia coli, Escherichia coli, Q4QK77, P43014, Escherichia coli, Haemophilus A5UEK1, B5XQC6, ducreyi, Haemophilus somnus, Q5F9U4, Q9K095, Haemophilus influenzae, A9M375, Q9JVA3, Haemophilus influenzae, B4ETK6, Q48JS3, Haemophilus influenzae, Q4ZUG7, Q883H9, Haemophilus influenzae, Klebsiella A6V485, B7V188, pneumoniae, Neisseria gonorrhoeae, Q9I099, Q02NP1, Neisseria meningitidis, Neisseria Q3KEY2, A4VM22, meningitidis, Neisseria meningitidis, B1J6U4, A4XTS1, Proteus mirabilis, Pseudomonas C3JZN7, Q88K27, savastanoi, Pseudomonas syringae, B0KKR8, A5W5E1, Pseudomonas syringae, Q1IC15, Q8XZ29, Pseudomonas aeruginosa, Q1MGA7 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas stutzeri, Pseudomonas putida, Pseudomonas mendocina, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Ralstonia solanacearum, Rhizobium leguminosarum 1575 QDFTGVPAVVD Escherichia coli, Pseudomonas P25516, Q9I3F5 P21399 aeruginosa 1576 QDPLAELVKI Escherichia coli P46837 Q8N5C6 1577 QDPLAELVKIEPK Haemophilus influenzae P71353 Q8N5C6 1578 QEEIFGPVL Staphylococcus aureus, Q7A1Y7, Q7A825, P30838 Staphylococcus aureus, Q99X54, Q6GCV9, Staphylococcus aureus, Q2G1J0, Q5HJK3, Staphylococcus aureus, Q2FK94, Q6GKD8, Staphylococcus aureus, Q2YV11 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1579 QGARLTAFEL Clostridium phytofermentans, A9KIE9, A1VHH2, Q9BV20 Desulfovibrio vulgaris, Desulfovibrio Q72FX9 vulgaris 1580 QGFFDIPVDNL Enterococcus faecalis, Streptococcus Q832Z5, Q99ZR0, P11908 pyogenes, Streptococcus pyogenes, Q5XC85, P0DCQ0, Streptococcus pyogenes, P0DC01, Q8P137, Streptococcus pyogenes, Q8E568, Q8DZK4, Streptococcus pyogenes, P65241, P65242, Streptococcus agalactiae, Q8DU94 Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus mutans 1581 QGMNAAVRAVVR Paenibacillus macquariensis Q59214 Q01813 1582 QGMRQGNDH Escherichia coli Q0T9G6 Q9UJ68 1583 QGMRQGNDHGT Escherichia coli, Escherichia B1LRA3, B7LMP0, Q9UJ68 QYRSAIYP fergusonii, Escherichia coli, B7NGF6, B7NUD2, Escherichia coli, Escherichia coli, B7MTA1, B7UQN3, Escherichia coli, Escherichia coli, P0A744, B1ISY2, Escherichia coli, Escherichia coli, A8A7X5, B1XDW8, Escherichia coli, Escherichia coli, C4ZR95, B7M9I1, Escherichia coli, Escherichia coli, B7LCT1, B7MLN1, Escherichia coli, Escherichia coli, A7ZV98, B5Z3H5, Escherichia coli, Escherichia coli, Q8XCG3, Q8FAG4, Escherichia coli, Klebsiella B5Y2Y3 pneumoniae 1584 QGNDHGTQYRSA Enterobacter sp. A4W5V5 Q9UJ68 IYP 1585 QGVLLLNAVLTV Leuconostoc mesenteroides Q03W63 P13051 1586 QGVLLLNAVLTVR Streptomyces avermitilis Q827B3 P13051 1587 QGVLLLNAVLTVR Streptomyces coelicolor Q9K3Z0 P13051 A 1588 QHLFWFFGHPEV Corynebacterium diphtheriae, Q6NFM3, Q8FMT1, P00395 Y Corynebacterium efficiens, Q79VD7 Corynebacterium glutamicum 1589 QHLFWFFGHPEV Streptomyces avermitilis, Q82AK9, Q828X4, P00395 Y1 Streptomyces avermitilis, Q9X813, Q9K451 Streptomyces coelicolor, Streptomyces coelicolor 1590 QILTEPRNA Streptococcus pyogenes, P0DA37, Q48U22, O76031 Streptococcus pyogenes, Q1J741, Q1JHC2, Streptococcus pyogenes, P63795, P0DA36, Streptococcus pyogenes, P63793 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 1591 QIQGFFDIP Bacillus subtilis, Bacillus caldolyticus, P14193, P42816, P11908 Bacillus cereus, Bacillus anthracis, Q81J97, Q81VZ0, Fusobacterium nucleatum, Q8RHM2, O33924, Corynebacterium ammoniagenes, Q4L3F7, Q8CQU7, Staphylococcus haemolyticus, Q5HRQ5, Q5HIH5, Staphylococcus epidermidis, Q6GJH1, P65237, Staphylococcus epidermidis, P65238, Q6GBY8, Staphylococcus aureus, P65236 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1592 QIQGFFDIPVD Bacillus halodurans, Lactobacillus Q9KGJ5, Q88VA5, P11908 plantarum, Clostridium Q97E93, P0DB99, acetobutylicum, Streptococcus P65245, Q5XEL0, pyogenes, Streptococcus pyogenes, P0DB98, P65243, Streptococcus pyogenes, P65240, P65239, Streptococcus pyogenes, Q8E2H0, Q8E7X8, Streptococcus pyogenes, Q8DWM2 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus mutans 1593 QIQGFFDIPVDN Pseudomonas aeruginosa, Ralstonia Q9HVC5, Q8Y2E1 P11908 solanacearum 1594 QIQGFFDIPVDNLY Helicobacter hepaticus Q7VFY9 P11908 1595 QIQNALGSDI Listeria innocua, Listeria welshimeri, Q92B14, A0AIX9, Q9BXR0 Listeria monocytogenes, Listeria B8DHL8, Q8Y700, monocytogenes, Listeria Q71ZE0, C1KVH7 monocytogenes, Listeria monocytogenes 1596 Q1YRIDHYLGKE Aggregatibacter P77809 P11413 actinomycetemcomitans 1597 QKEVAERLAA Lactobacillus delbrueckii, Q04C60, Q1GBR1, Q8WVM0 Lactobacillus delbrueckii, A6LF39 Parabacteroides distasonis 1598 QKEVAERLAAN Lactobacillus salivarius Q1WV73 Q8WVM0 1599 QKGTGRARH Rhizobium loti, Rhizobium Q98N56, B5ZYT6, Q9BYD3 leguminosarum, Rhizobium etli, Q2K9L5, Q1MIE0, Rhizobium leguminosarum, B3PWS2, Q92QG9, Rhizobium etli, Rhizobium meliloti, C3MAY1 Rhizobium sp. 1600 QLDTPERGFS Clostridium novyi, Clostridium A0Q055, A9KM86 A6NJ78 phytofermentans 1601 QLKGAGPTPFSR Rhizobium leguminosarum, B5ZUP2, B3PTN1, Q9BVL4 Rhizobium etli, Rhizobium Q1MJK8 leguminosarum 1602 QLKQFTTVVADTG Pseudomonas stutzeri, Pseudomonas A4VK43, Q88KX1, P37837 D putida, Pseudomonas putida, B1J623, B0KHA7, Pseudomonas putida, Pseudomonas Q1I7G7, A4XTM7 entomophila, Pseudomonas mendocina 1603 QLKQFTTVVADTG Pseudomonas fluorescens Q3K9H0 P37837 DF 1604 QLSGGQKQR Bacillus subtilis, Bacillus anthracis, O34900, Q81ZF5, Q2M3G0 Bacillus cereus, Bacillus thuringiensis, Q81IN8, Q6HP89, Bacillus halodurans, Bifidobacterium Q9K789, Q8G5P8, longum, Corynebacterium Q8N5N2, Q4JTG9, glutamicum, Corynebacterium Q8FRX8, Q831K6, jeikeium, Corynebacterium efficiens, Q92EZ6, Q724C0, Enterococcus faecalis, Listeria Q8YA75, Q6A6X6 innocua, Listeria monocytogenes, Listeria monocytogenes, Propionibacterium acnes 1605 QLSGGQKQRV Bacillus licheniformis, Bacillus clausii, Q65F80, Q5WDP1, Q9NP78 Bacillus cereus, Bacillus subtilis, Q73EL7, O32169, Bacillus cereus, Fusobacterium Q63GR8, Q8RFN2, nucleatum, Desulfitobacterium Q240I5 hafniense 1606 QLSGGQKQRVA Leuconostoc mesenteroides, Q03Z27, Q03EE4 Q9NP78 Pediococcus ntosaceus 1607 QLYQRSGDM Lactobacillus gasseri, Lactobacillus Q044A1, Q5FKL6, P04818 acidophilus, Lactobacillus delbrueckii, Q041329, Q1GAP2, Lactobacillus delbrueckii, Q74IU3 Lactobacillus johnsonii 1608 QMQYNLRLR Ralstonia solanacearum Q8Y270 Q6PI48 1609 QPPKGVLLYGPP Corynebacterium aurimucosum, C3PGA0, C4LIL2 Q8NBU5 GCGKTLIAKA Corynebacterium kropnstedtii 1610 QREDDKPETV Streptococcus mutans, Streptococcus Q8D533, A3CK85, Q9UIJ7 sanguinis, Streptococcus Q5LXT2, Q5M2D4, thermophilus, Streptococcus Q03IH2, C1CAN3, thermophilus, Streptococcus Q97SU1, B2IS63, thermophilus, Streptococcus B5E6H6, C1CPA9, pneumoniae, Streptococcus C1CIB8, B1I8L9, pneumoniae, Streptococcus C1CC27, Q04ML5, pneumoniae, Streptococcus Q8DRD4, B8ZKQ1, pneumoniae, Streptococcus C0ME26, C0M6X3, pneumoniae, Streptococcus A8AZK4, P69882, pneumoniae, Streptococcus Q1J8Z2, P0DB92, pneumoniae, Streptococcus P0DB93, P65204, pneumoniae, Streptococcus P65203, B9DSX1, pneumoniae, Streptococcus Q1JJ40, Q48V58, pneumoniae, Streptococcus B5XJ57, Q1JE38, pneumoniae, Streptococcus equi, Q1JNZ6, Q8P2Z4, Streptococcus equi, Streptococcus Q5XEB4, A2RC35, gordonii, Streptococcus pyogenes, Q3K3U8 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus uberis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae 1611 QRIAIARAL Escherichia coli, Escherichia coli, Q47258, Q8FDZ8, Q9NRK6 Escherichia coli, Escherichia coli, P10089, P08716, Escherichia coli, Proteus vulgaris Q46717, P11599 1612 QRIAIARALV Clostridium novyi, ptoclostridium A0PY57, Q18AM3 Q2M3G0 difficile 1613 QRLAIARAL Haemophilus influenzae, Q40PI4, Q7VL52, Q9NUT2 Haemophilus ducreyi, Haemophilus P44407, Q0I4C5, influenzae, Haemophilus somnus, P45082, Q9HUG8, Haemophilus influenzae, Q3KJ31, Q88D92, Pseudomonas aeruginosa, Q4KJB2, Q48P40, Pseudomonas fluorescens, Q4ZZ16, Q87VF3 Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas syringae 1614 QRQATKDAG Bacillus clausii, Bacillus halodurans, Q5WHG1, Q9KD72, P11021 Lactobacillus acidophilus, Q84BU4, Q03QU1, Lactobacillus brevis, Bifidobacterium A1A3P5, A3DF25, adolescentis, Clostridium P30721, B9E041, thermocellum, Clostridium A5N6M2, A6LRN4, acetobutylicum, Clostridium kluyveri, Q892R0, B1KZN7, Clostridium kluyveri, Clostridium A7GHH6, C1FVU0, beijerinckii, Clostridium tetani, A5I640, A7FXL5, Clostridium botulinum, Clostridium B1ILM3, C3L3G7, botulinum, Clostridium botulinum, B1VHX4, Q74H59, Clostridium botulinum, Clostridium Q39PT7, B3E7W9, botulinum, Clostridium botulinum, B9M357, A5GDC8, Clostridium botulinum, C6E643, B5EC42, Corynebacterium urealyticum, A1KSG3, Q9K0N4, Geobacter sulfurreducens, Geobacter Q5F6W5, A9M296, metallireducens, Geobacter lovleyi, Q9JVQ9, Q3KIA0, Geobacter daltonii, Geobacter A4XYF6, B7V1H3, uraniireducens, Geobacter sp., Q9HV43, Q02FR1, Geobacter bemidjiensis, Neisseria A6VCL8, Q88DU2, meningitidis, Neisseria meningitidis, A5W9A3, Q4ZNP7, Neisseria gonorrhoeae, Neisseria Q1IF59, B1J254, meningitidis, Neisseria meningitidis, Q48E62, Q87WP0, Pseudomonas fluorescens, Q4KIH1, B0KIS5, Pseudomonas mendocina, A4VPQ5, B2UBP3, Pseudomonas aeruginosa, Q8XW40, B2FMY5, Pseudomonas aeruginosa, B4SSQ6 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas putida, Pseudomonas syringae, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas stutzeri, Ralstonia pickettii, Ralstonia solanacearum, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1615 QRRQALRQLDG Methylobacterium radiotolerans B1M0E0 Q969Y2 1616 QRVAIARAI Lactobacillus gasseri, Lactobacillus Q042G7, Q74K65, O75027 johnsonii, Lactobacillus delbrueckii, Q1GB17, Q5FL41, Lactobacillus acidophilus, Q04BG2, Q1WV17, Lactobacillus delbrueckii, Q830W6, Q8Y8T6, Lactobacillus salivarius, Enterococcus Q72261, A0AGP9, faecalis, Listeria monocytogenes, Q92DL6, Q8DUF7 Listeria monocytogenes, Listeria welshimeri, Listeria innocua, Streptococcus mutans 1617 QRVTRASVTV Citrobacter koseri, Enterobacter sp., A8AL53, A4WGB6, Q8TEA8 Escherichia coli, Escherichia B7N2M8, B7LVG2, fergusonii, Escherichia coli, Q1R431, B1LMS1, Escherichia coli, Escherichia coli, B6I4M4, B7NFI6, Escherichia coli, Escherichia coli, P0A6M4, A8A6Y8, Escherichia coli, Escherichia coli, B1IVJ1, Q0TAH5, Escherichia coli, Escherichia coli, P0A6M5, A1A164, Escherichia coli, Escherichia coli, C5A055, B1X1355, Escherichia coli, Escherichia coli, B7M686, B5YZ24, Escherichia coli, Escherichia coli, B7MI18, P0A6M6, Escherichia coli, Escherichia coli, B7L9D6, B7UNK4, Escherichia coli, Escherichia coli, A7ZU92, B7NUY4 Escherichia coli 1618 QSLAIIEYL Rhizobium meliloti Q9X4F7 O43708 1619 QSPDIAQGV Streptomyces griseus, Streptomyces B1W470, Q9L0Y3 P31153 coelicolor 1620 QSSNDTFPTA Corynebacterium glutamicum, Q8NRN8, Q8FQP8 P07954 Corynebacterium efficiens 1621 QTLLFSATMP Bacillus licheniformis, Bacillus subtilis, Q65N62, P96614, Q9UJV9 Bacillus cereus, Bacillus thuringiensis, Q73EU1, Q6HPE6, Bacillus thuringiensis, Bacillus A0R8U6, Q81VG0, anthracis, Bacillus cereus, Bacillus Q63GX5, Q81IT9 cereus 1622 QTREQHIRR Pseudomonas aeruginosa, Q9II37, C3JYR1, P23378 Pseudomonas fluorescens, Q3K7X5, Q88P65 Pseudomonas fluorescens, Pseudomonas putida 1623 QVDTTNILF Leuconostoc citreum, Rhizobium B1MXT8, Q1MIM6, O76Q31 leguminosarum, Rhizobium meliloti, Q92QQ2, B5ZY09, Rhizobium leguminosarum, Q2K9U6, B3PVY5, Rhizobium etli, Rhizobium etli, C3MA45 Rhizobium sp. 1624 QVEHPVTEMITG Escherichia coli, Escherichia coli, P24182, Q8X9B6, Q96R03 Haemophilus influenzae P43873 1625 QVVAPSDMMDGR Pseudomonas aeruginosa Q59643 P13716 1626 QVVGDEGKGK Arcobacter butzleri, Lactobacillus A8ER43, Q88SV6, Q8N142 plantarum, Lactobacillus salivarius, Q1WRH2, B2G550, Lactobacillus reuteri, Lactobacillus A5VHM0, A8YTK4, reuteri, Lactobacillus helveticus, A7ZAP4, Q74KY3, Bacillus methylotrophicus, Q65CR5, Q5WAI0, Lactobacillus johnsonii, Bacillus A7GVN0, Q03TS9, licheniformis, Bacillus clausii, Bacillus Q045S7, A8FJC0, cytotoxicus, Lactobacillus brevis, Q9K5R0, B2GEZ1, Lactobacillus gasseri, Bacillus Q81JI9, A0RLP6, pumilus, Bacillus halodurans, Q6HAG9, Q72WW1, Lactobacillus fermentum, Bacillus Q630D5, Q814H1, anthracis, Bacillus thuringiensis, P29726, O68581, Bacillus thuringiensis, Bacillus cereus, P58793, A7I328, Bacillus cereus, Bacillus cereus, A0RMY9, B9KF91, Bacillus subtilis, Fusobacterium A7ZFJ4, A7H0A8, nucleatum, Fusobacterium nucleatum, A8AMM3, A3DK09, Campylobacter hominis, A5N4D3, B815L3, Campylobacter fetus, Campylobacter C6BRT2, A4W5R8, lari, Campylobacter concisus, Q839Y4, BILQJ7, Campylobacter curvus, Citrobacter Q1R383, B1IT29, koseri, Clostridium thermocellum, B1XDS8, B7NGB1, Clostridium kluyveri, Clostridium A1AJ82, B7MSJ5, cellulolyticum, Desulfovibrio B7LLV9, Q0T9L6, salexigens, Enterobacter sp., P0A7D4, B7M8T7, Enterococcus faecalis, Escherichia P0A7D5, B6I281, coli, Escherichia coli, Escherichia coli, B7NTN3, A8A7S2, Escherichia coli, Escherichia coli, B7UQI6, B7LC36, Escherichia coli, Escherichia coli, C4ZR54, B5Z2I3, Escherichia fergusonii, Escherichia P0A7D6, B7MKY1, coli, Escherichia coli, Escherichia coli, A7ZV47, B6JKI4, Escherichia coli, Escherichia coli, Q1CUP8, B5ZA21, Escherichia coli, Escherichia coli, Q9ZMI1, P56137, Escherichia coli, Escherichia coli, B2US87, Q17W85, Escherichia coli, Escherichia coli, A6TH93, B5Y325, Escherichia coli, Escherichia coli, Q03W69, B1N002, Escherichia coli, Helicobacter pylori, B8DAL0, Q725A8, Helicobacter pylori, Helicobacter C1KV62, Q8YAR1, pylori, Helicobacter pylori, A0AEN2, Q92FQ5, Helicobacter pylori, Helicobacter Q03ET4, Q7MWW8, pylori, Helicobacter acinonychis, Q6A6A3, B4F271, Klebsiella pneumoniae, Klebsiella Q4KJ68, A4XPZ3, pneumoniae, Leuconostoc B1JA10, Q88DD8, mesenteroides, Leuconostoc citreum, A5W9S5, B0KKZ0, Listeria monocytogenes, Listeria Q3KIY4, B7V201, monocytogenes, Listeria Q02F80, Q9HUM6, monocytogenes, Listeria Q1I454, C3KDW8, monocytogenes, Listeria welshimeri, A6VD51, Q4ZYX5, Listeria innocua, Pediococcus Q48NZ7, Q87VJ9, ntosaceus, Porphyromonas gingivalis, Q98F97, Q92MA5, Propionibacterium acnes, Proteus Q2K4X9, B3PY13, mirabilis, Pseudomonas fluorescens, C3MI14, Q1MCS2, Pseudomonas mendocina, B5ZMS8, Q5HK16, Pseudomonas putida, Pseudomonas Q8CQK1, Q4LAK0, putida, Pseudomonas putida, Q9A1P8, Q1J8S0, Pseudomonas putida, Pseudomonas Q48VK8, Q1JIX0, fluorescens, Pseudomonas P0DD55, P0DD54, aeruginosa, Pseudomonas Q5M2A7, Q5LXQ5, aeruginosa, Pseudomonas C0MFY0, B9DT31, aeruginosa, Pseudomonas Q03IE5, Q8P2U1, entomophila, Pseudomonas Q5XE45, C0MAE4, fluorescens, Pseudomonas A2RCA2, Q1JNS3, aeruginosa, Pseudomonas syringae, B5XJH8, A8AZM9, Pseudomonas savastanoi, Q8DW14, Q04N48, Pseudomonas syringae, Rhizobium P65887, B8ZJJ5, loti, Rhizobium meliloti, Rhizobium P65888, A3CQU5, etli, Rhizobium etli, Rhizobium sp., P65885, P65886, Rhizobium leguminosarum, Q3JZ68, A4W440 Rhizobium leguminosarum, **** Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus equi, Streptococcus uberis, Streptococcus thermophilus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus equi, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus gordonii, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus suis 1627 QWGDEGKGKV Desulfitobacterium hafniense, B8G0I5, Q24MC6, Q8N142 Desulfitobacterium hafniense, Q18107, B1H0H8 ptoclostridium difficile, Uncultured termite 1628 QWGDEGKGKVVD Parabacteroides distasonis, A6LIF5, Q64QR7, Q8N142 Bacteroides fragilis, Bacteroides Q5LAD5, A6L1X1, fragilis, Bacteroides vulgatus, Q8A6N4, Q5H5T3, Bacteroides thetaiotaomicron, A7H5L7, A1W1A5, Campylobacter jejuni, Campylobacter A8FNG4, Q9PMG4, jejuni, Campylobacter jejuni, Q7VHL2 Campylobacter jejuni, Campylobacter jejuni, Helicobacter hepaticus 1629 QWGDEGKGKVVD Edwardsiella ictaluri O31047 Q8N142 LL 1630 QYHPEFLSRP Lactobacillus helveticus, Lactobacillus A8YXF8, Q1GBQ2 P17812 delbrueckii 1631 QYLAAAGVG Haemophilus influenzae P45211 O95396 1632 RAAVPSGASTG Clostridium kluyveri, Clostridium A5N2N5, B9E6B1, P06733 kluyveri, Clostridium beijerinckii, A6LR09, B2TPW4, Clostridium botulinum, Clostridium B2UY16, AlVGV5, botulinum, Desulfovibrio vulgaris, Q72F92, A5GEW5, Desulfovibrio vulgaris, Geobacter B9M3M1, C6E471, uraniireducens, Geobacter daltonii, B5EGF2, Q39T27, Geobacter sp., Geobacter Q74AR6, B3E258, bemidjiensis, Geobacter B2FK88, B45R86 metallireducens, Geobacter sulfurreducens, Geobacter lovleyi, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1633 RAAVPSGASTGI Clostridium tetani Q898R0 P06733 1634 RAAVPSGASTGIY Clostridium perfringens, Clostridium Q0STE0, Q0TQZ2, P06733 EA perfringens, Clostridium perfringens Q8XKU4 1635 RAGGKHNDL Aeromonas hydrophila, Aeromonas A0KPG1, A4SS99, P49588 salmonicida, Arcobacter butzleri, A8EWI6, A8ANQ1, Citrobacter koseri, Enterobacter sp., A4WDQ6, A8A3H4, Escherichia coli, Escherichia coli, B1LQ15, Q1R804, Escherichia coli, Escherichia coli, A1AEN7, A7ZQC5, Escherichia coli, Escherichia coli, Q8X3W8, Q0TEI3, Escherichia coli, Escherichia coli, P00957, B1XCM5, Escherichia coli, Escherichia coli, B1IUY2, A5GD98, Geobacter uraniireducens, Q0I426, A5UHW6, Haemophilus somnus, Haemophilus Q4QM86, A5UDR0, influenzae, Haemophilus influenzae, Q7VLK0, Q1CS22, Haemophilus influenzae, Q9ZJY5, Q17ZF3, Haemophilus ducreyi, Helicobacter P56452, B2UV04, pylori, Helicobacter pylori, A6TCV9, A9M198, Helicobacter acinonychis, A1KV20, Q5F7C4, Helicobacter pylori, Helicobacter Q9JTG4, Q9JYG6, pylori, Klebsiella pneumoniae, A4VJB3, Q02I63, Neisseria meningitidis, Neisseria Q9IS53, A6VA71, meningitidis, Neisseria gonorrhoeae, A4XWE2, Q885J0, Neisseria meningitidis, Neisseria Q4K843, Q4ZQI4, meningitidis, Pseudomonas stutzeri, Q1I6Z8, Q3K892, Pseudomonas aeruginosa, Q48G25, B0KR43, Pseudomonas aeruginosa, Q88EI8, A5W0D9, Pseudomonas aeruginosa, B1JCG9, Q8Y193 Pseudomonas mendocina, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas syringae, Pseudomonas entomophila, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Ralstonia solanacearum 1636 RAGGKHNDLD Acinetobacter baumannii, B0VAI3, A3M3W2, P49588 Acinetobacter baumannii, B2HWK7, Q6FCT2, Acinetobacter baumannii, B0UGC4, A9W5Y4, Acinetobacter baylyi, B1M0N0, B1ZC90, Methylobacterium sp., P27866, Q2K7T4, Methylobacterium extorquens, Q1MFZ9, Q98NQ5, Methylobacterium radiotolerans, A5V3L0, B2FL33 Methylobacterium populi, Rhizobium meliloti, Rhizobium etli, Rhizobium leguminosarum, Rhizobium loti, Sphingomonas wittichii, Stenotrophomonas maltophilia 1637 RALFGTIDSWL Sphingomonas wittichii A5VE44 Q14409 1638 RASGAGGQH Acinetobacter baumannii, B2HU82, A3M6N7, Q9UGC7 Acinetobacter baumannii, B0VM26, B0V7E0, Acinetobacter baumannii, B7IBA1, B7H0L9, Acinetobacter baumannii, Q6F9S2, Q38WJ4, Acinetobacter baumannii, Q9JY93, AlKV95, Acinetobacter baumannii, Q9JT75, A9M1Q8, Acinetobacter baylyi, Lactobacillus Q5F750, B4RN52, sakei, Neisseria meningitidis, B2UDM7, Q8XVD0, Neisseria meningitidis, Neisseria B1GZI5 meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria gonorrhoeae, Ralstonia pickettii, Ralstonia solanacearum, Uncultured termite 1639 RASGAGGQHVN Aeromonas salmonicida, Aeromonas A4SK64, A0KMZ8, Q9UGC7 hydrophila, Desulfovibrio B8J4R4, A1VAK8, desulfuricans, Desulfovibrio vulgaris, Q727E1, B8DLL6, Desulfovibrio vulgaris, Desulfovibrio Q39YQ1, Q74861, vulgaris, Geobacter metallireducens, Q1IEX1, B1JEP6, Geobacter sulfurreducens, Q88PW5, B0KNE4, Pseudomonas entomophila, A5VYG5 Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 1640 RAVLHVALR Ralstonia pickettii B2UF65 P06744 1641 RAVLHVALRNR Desulfovibrio maeticus, Neisseria C4XST3, Q9JYX3, P06744 meningitidis, Neisseria meningitidis, Q9JTW1, Q5F8P8 Neisseria gonorrhoeae 1642 RAVLHVALRNRSN Citrobacter koseri, Enterobacter sp., A8ANA6, A4W5E0, P06744 TPI Klebsiella pneumoniae, Klebsiella A6TGT4, B5XY03 pneumoniae 1643 RAVLHVALRNRSN Escherichia fergusonii, Escherichia B7LKZ8, B1LPI9, P06744 TPILVDGKDVMPE coli, Escherichia coli, Escherichia coli, C5A0W2, B1IUM7, VN Escherichia coli, Escherichia coli, P0A6T1, P0A6T2, Escherichia coli, Escherichia coli, B7LAX0, B1XC24, Escherichia coli, Escherichia coli, B5Z0C4, Q8FB44, Escherichia coli, Escherichia coli, Q0TA36, Q1R3R3, Escherichia coli, Escherichia coli, B7MRF7, A1AIK3, Escherichia coli, Escherichia coli, B7NRZ0, B7UPI6, Escherichia coli, Escherichia coli, B7MJ15, B615N7, Escherichia coli, Escherichia coli, A8A7C4, A7ZUP3, Escherichia coli, Escherichia coli B7M7T4, B7NFW8 1644 RDCSIQRRHQK Bacillus halodurans Q9KDS9 O00763 1645 RDCSVQRRHQK Bacillus subtilis, Bacillus subtilis O34544, Q9KWU4 Q13085 1646 RDGFVMGEGA Bacillus subtilis, Staphylococcus O34340, Q8NXE1, Q9NWU1 aureus, Staphylococcus aureus, Q6GAU2, Q5HHA1, Staphylococcus aureus, Q7A6F8, Q99VA6, Staphylococcus aureus, Q6GIA3, Q5TKS0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1647 RDGFVMGEGAAV Streptomyces cyaneus Q02578 Q9NWU1 LVLEE 1648 RDGKLYGRGS Acinetobacter baumannii, B0VRY3, B7GXA3, Q96KP4 Acinetobacter baumannii, B0V4V8, B7I842, Acinetobacter baumannii, A3M8H2, B2HY23 Acinetobacter baumannii, Acinetobacter baumannii, Acinetobacter baumannii 1649 RDHRKIGKE Parabacteroides distasonis, A6L952, Q64VP2, A2RTX5 Bacteroides fragilis, Bacteroides Q5LEQ6, A6L7J7, fragilis, Bacteroides vulgatus, Q8AAP2, Q97GK4, Bacteroides thetaiotaomicron, B2RJD6, Q7MVQ5, Clostridium acetobutylicum, Q2FXP7, Q8NW68, Porphyromonas gingivalis, A8Z2J8, Q6G8P3, Porphyromonas gingivalis, Q6GG23, A6QHL6, Staphylococcus aureus, Q5HF90, A5ITK7, Staphylococcus aureus, Q2FG54, A6U2F0, Staphylococcus aureus, Q2YTA7, B9DNC9, Staphylococcus aureus, P67584, P67585, Staphylococcus aureus, A7X3A6, Q49YB4 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus carnosus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus 1650 RDMKPENVL Streptomyces toyocaensis Q9KIG4 Q8WTQ7 1651 RDPRGFAVKFYTE Pseudomonas putida Q59714 P04040 1652 REGNDLYHEM Clostridium botulinum, Clostridium B2TKQ0, B2UZK0 P06576 botulinurn 1653 REILDSRGNPTVE Porphyromonas gingivalis, Q7MTV8, B2RLL7 P09104 VD Porphyromonas gingivalis 1654 REKLDGLYECILC Escherichia coli P07014 P21912 ACCSTSCPS 1655 RELLAVPDNY Ralstonia solanacearum Q8Y0Z0 Q9Y617 1656 REQHIRRDKATSN Bacillus subtilis, Bacillus cereus, P54376, Q730W2, P23378 IC Bacillus thuringiensis, Bacillus cereus, Q6HDT7, Q818M4, Bacillus cereus, Bacillus cereus, B7HB99, B7IXL3, Bacillus cereus, Bacillus cereus, B9IXL8, B7HNZ0, Bacillus cereus, Bacillus cereus, Q634V7, C1ERU9, Bacillus cereus, Bacillus thuringiensis, B7JMV0, A0RIL0, Bacillus anthracis, Bacillus anthracis, Q81M07, C3LKQ3, Bacillus anthracis, Bacillus C3P8D4, A9VH11, weihenstephanensis, Bacillus A7GSN7, Q65HG0, cytotoxicus, Bacillus licheniformis, A7Z6M3, A8FF40, Bacillus methylotrophicus, Bacillus Q92C05, Q71ZX3, pumilus, Listeria innocua, Listeria C1L2Q5, B8DFX9, monocytogenes, Listeria Q8Y7D4, A0AIF0, monocytogenes, Listeria B9DNN6, Q6GGG3, monocytogenes, Listeria P64218, P64217, monocytogenes, Listeria welshimeri, A5IT64, A6U207, Staphylococcus carnosus, A7X250, Q5HFM3, Staphylococcus aureus, Q8NWC9, Q2FY34, Staphylococcus aureus, Q2FGI6, Q6G930, Staphylococcus aureus, Q49XY0, Q4L6N6, Staphylococcus aureus, Q5HP13, Q8CMM0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 1657 RERIPERVVHA Streptomyces venezuelae, P33569, Q9Z598 P04040 Streptomyces coelicolor 1658 RERIPERVVHAKG Rhizobium meliloti P95631 P04040 1659 RERIPERVVHAKG Lactobacillus sakei P30265 P04040 AGA 1660 RETDTMDTFV Geobacter sulfurreducens, Geobacter Q74AZ0, Q39T99, O15031 metallireducens, Geobacter A5G677, C6E100, uraniireducens, Geobacter sp., B5EE39, B9M9F3 Geobacter bemidjiensis, Geobacter daltonii 1661 RETDTMDTFVDS Rhizobium etli, Rhizobium sp., Q2K257, C3MB60, Q15031 Rhizobium leguminosarum, Q1MA25, B3P546, Rhizobium etli, Rhizobium B5ZV40, Q92KW8, leguminosarum, Rhizobium meliloti, Q98EU7 Rhizobium loti 1662 REVDALDGL Methylobacterium sp., B0UJI8, B1M186, Q9Y2Z2 Methylobacterium radiotolerans, B1ZGG2 Methylobacterium populi 1663 RFAPSPTGFLH Aeromonas hydrophila, Aeromonas A0KNT0, A4SJD4, Q5JPH6 salmonicida, Methylobacterium sp., B0UQ09, B1Z9T1, Methylobacterium populi, A9W910 Methylobacterium extorquens 1664 RGANLSGGQ Haemophilus influenzae P71355 O15440 1665 RGERAYDIYSRLL Lactobacillus fermentum, B2GAL4, B3WCR2, Q16740 Lactobacillus casei, Lactobacillus Q03AL0, A7Z939, casei, Bacillus methylotrophicus, Q88YH9, P80244, Lactobacillus plantarum, Bacillus Q65EI5, Q74K84, subtilis, Bacillus licheniformis, Q042E8, Q1GB31, Lactobacillus johnsonii, Lactobacillus Q04BH7, Q631K2, gasseri, Lactobacillus delbrueckii, Q6HBD8, Q815J6, Lactobacillus delbrueckii, Bacillus Q72XW9, Q5FL55, cereus, Bacillus thuringiensis, Bacillus A8FHN9, Q81X63, cereus, Bacillus cereus, Lactobacillus A8YUD9, Q9K709, acidophilus, Bacillus pumilus, Bacillus Q38Y96, B2G613, anthracis, Lactobacillus helveticus, A5VI14, Q03SM3, Bacillus halodurans, Lactobacillus Q5WDK0, Q837R0, sakei, Lactobacillus reuteri, Q928C4, Q9RQI6, Lactobacillus reuteri, Lactobacillus Q71WV9, Q03GX1, brevis, Bacillus clausii, Enterococcus Q88KJ0, A5W635, faecalis, Listeria innocua, Listeria B1J692, B0KJG6, monocytogenes, Listeria Q1ICA8, Q4ZVM7, monocytogenes, Pediococcus Q87YR6, Q48KZ0, ntosaceus, Pseudomonas putida, Q3K9W9, Q4K9J6, Pseudomonas putida, Pseudomonas C3JYK0, A4XTZ5, putida, Pseudomonas putida, Q9I2U1, Q49VZ2, Pseudomonas entomophila, Q4L4J5, P63785, Pseudomonas syringae, P99089, P63786, Pseudomonas syringae, A8Z045, Q6GB62, Pseudomonas savastanoi, Q6GIM3, Q2G036, Pseudomonas fluorescens, A6QF76, Q5HHQ0, Pseudomonas fluorescens, Q2YSF8, A5IQX2, Pseudomonas fluorescens, A7WZR9, Q2F1M5, Pseudomonas mendocina, A6TZP7, B9DJL4, Pseudomonas aeruginosa, Q5HQW0, Q8CTE0, Staphylococcus saprophyticus, B2FQR2 Staphylococcus haemolyticus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus carnosus, Staphylococcus epidermidis, Staphylococcus epidermidis, Stenotrophomonas maltophilia 1666 RGFAVKFYT Pseudomonas putida P95539 P04040 1667 RGITIQSAAT Bifidobacterium adolescentis, A1A0T0, B1MW21, 096RP9 Leuconostoc citreum, Leuconostoc Q03ZQ2, B2FQ42, mesenteroides, Stenotrophomonas B4SKW0 maltophilia, Stenotrophomonas maltophilia 1668 RGKGLMIGIE Bacillus cereus Q818W2 Q9BYV1 1669 RGLDYYTGVI Lactobacillus helveticus, Lactobacillus A8YUZ9, Q5FKI5, P12081 acidophilus, Lactobacillus gasseri, Q043X4, Q1GAG8, Lactobacillus delbrueckii, Q04AV4 Lactobacillus delbrueckii 1670 RGRSINLAL Pseudomonas fluorescens Q84HF5 O15229 1671 RGSGGFGSTG Helicobacter pylori, Helicobacter B6JM89, Q1CT07, P33316 pylori, Helicobacter pylori, O25536, B2USW5, Helicobacter pylori, Helicobacter Q9ZKY3, Q17WJ4 pylori, Helicobacter acinonychis 1672 RHPFPGPGL Acinetobacter baylyi, Aeromonas Q6FFN2, A0KJS0, P49915 hydrophila, Aeromonas salmonicida, A4SM23, Q8RDR4, Fusobacterium nucleatum, Citrobacter A8AD80, Q18CT8, koseri, ptoclostridium difficile, C5BER5, A4WQ82, Edwardsiella ictaluri, Enterobacter B7UGU5, B7LKD4, sp., Escherichia coli, Escherichia P64294, Q0TEY1, fergusonii, Escherichia coli, B1LNF9, B7MYD5, Escherichia coli, Escherichia coli, A8A313, A1AE43, Escherichia coli, Escherichia coli, B6IS79, B1IWF4, Escherichia coli, Escherichia coli, B7M7L1, Q1R8M9, Escherichia coli, Escherichia coli, B7LCP7, B7NQV3, Escherichia coli, Escherichia coli, B7MHY8, B5Z0X6, Escherichia coli, Escherichia coli, P64295, B1XAY2, Escherichia coli, Escherichia coli, C4ZX82, P04079, Escherichia coli, Escherichia coli, A7ZPV1, B7N691, Escherichia coli, Escherichia coli, A5UG27, A5UAR3, Escherichia coli, Haemophilus A6TCC2, B5XNM4, influenzae, Haemophilus influenzae, A1KRY5, Q9JW60, Klebsiella pneumoniae, Klebsiella Q4ZX09, Q48LY0, pneumoniae, Neisseria meningitidis, Q886X5, Q4K6W4, Neisseria meningitidis, Pseudomonas Q3K7D0, B1JDH6, syringae, Pseudomonas savastanoi, C3K1K0, B2FNS1, Pseudomonas syringae, B4SSX7 Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas putida, Pseudomonas fluorescens, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1673 RHPFPGPGLA Helicobacter acinonychis, Q17YH9, O25165, P49915 Helicobacter pylori, Helicobacter B6JMN5, Q1CSM2 pylori, Helicobacter pylori 1674 RHPFPGPGLAIR Campylobacter jejuni, Campylobacter Q5HTL3, A8FMV3, P49915 jejuni, Helicobacter pylori, Q9ZKG4, B2UUF1, Helicobacter pylori, Rhizobium etli, Q2KDG7, B3PYH7, Rhizobium etli, Rhizobium B5ZYE9, Q1MMJ7, leguminosarum, Rhizobium Q987R3 leguminosarum, Rhizobium loti 1675 RHPFPGPGLAIRVI Desulfovibrio vulgaris B8DNB9 P49915 1676 RIDHYLGKE Rhizobium meliloti Q9Z3S2 P11413 1677 RIDHYLGKEM Streptococcus pneumoniae O54537 P11413 1678 RIDHYLGKEMVQN Leuconostoc mesenteroides P11411 P11413 1679 RIINEPTAA Clostridium novyi, Desulfovibrio A0Q1R4, Q313S2 P11021 alaskensis 1680 RIINEPTAAA Bacillus licheniformis, Clostridium Q65H54, B2V2I5, P11142 botulinum, Clostridium botulinum, B2TLZ7, Q5HNW6, Staphylococcus epidermidis, Q8CP17, Q49Y22 Staphylococcus epidermidis, Staphylococcus saprophyticus 1681 RIIVEKPFG Haemophilus influenzae P44311 P11413 1682 RI LLDAPCS Pseudomonas aeruginosa, Q9I7A9, Q88641, Q8TEA1 Pseudomonas syringae, Q88RR3 Pseudomonas putida 1683 RIRFTSPHP Arcobacter butzleri A8ERE9 Q965Z6 1684 RKICAIGVR Bacteroides thetaiotaomicron, Q8A858, Q64UP8, A6NK58 Bacteroides fragilis, Bacteroides Q5LDM3 fragilis 1685 RKLALKYHPD Campylobacter hominis, Clostridium A7I2G3, A5N6M3 Q8WW22 kluyveri 1686 RLAIARALL Escherichia coli P23886 Q2M3G0 1687 RLDILVNNAG Pseudomonas aeruginosa Q9RPT1 P15428 1688 RLEFLGDAIL Pseudomonas aeruginosa, A6VAK6, Q9XCX9, Q9UPY3 Pseudomonas aeruginosa, Q02HS2, B7UYX2, Pseudomonas aeruginosa, Q1I5V8, B0KV27, Pseudomonas aeruginosa, Q88MY5, A5W8F2, Pseudomonas entomophila, Q4KHT1, B1J4E0, Pseudomonas putida, Pseudomonas Q87XG1, Q4ZPE1, putida, Pseudomonas putida, Q48EV3, A4XSC4, Pseudomonas fluorescens, C3K6Y7, Q3KHL9 Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi, Pseudomonas mendocina, Pseudomonas fluorescens, Pseudomonas fluorescens 1689 RLEFLGDAILD Bacteroides vulgatus, Bacteroides A6KZ76, Q5LIS2, Q9UPY3 fragilis, Bacteroides fragilis Q64ZV9 1690 RLEYRGYDSAG Corynebacterium glutamicum Q8NND3 Q06210 1691 RLEYRGYDSAGV Corynebacterium diphtheriae, Q6NG33, Q8FNH2, Q06210 Corynebacterium efficiens, Q9HT25 Pseudomonas aeruginosa 1692 RLGFEGGQTP Bacillus cereus, Bacillus B7IT38, A9VP96, Q9P015 weihenstephanensis, Bacillus Q6HPN9, B9IZL3, thuringiensis, Bacillus cereus, Bacillus Q63H71, B7JKD8, cereus, Bacillus cereus, Bacillus C3LJA1, A0R8J9, anthracis, Bacillus thuringiensis, B7HQW3, C1ET58, Bacillus cereus, Bacillus cereus, Q81VR1, C3P9S4, Bacillus anthracis, Bacillus anthracis, Q73F77, Q81J23, Bacillus cereus, Bacillus cereus, B7HJ67, A7GK39, Bacillus cereus, Bacillus cytotoxicus, Q839E5, B5XJ55, Enterococcus faecalis, Streptococcus P0DE07, Q48VT0, pyogenes, Streptococcus pyogenes, Q1J8Z4, A2RC33, Streptococcus pyogenes, Q1JNZ8, Q1JE40, Streptococcus pyogenes, Q1JJ43, Q7CNP1, Streptococcus pyogenes, P0DE06, Q5XEB6, Streptococcus pyogenes, Q9A1V5, A8AZK6, Streptococcus pyogenes, C0ME24, B4U519, Streptococcus pyogenes, C0MBW6, A3CK83, Streptococcus pyogenes, C1CIB6, C1CPA7, Streptococcus pyogenes, C1CC25, B2IS59, Streptococcus pyogenes, Q8CVVV0, Q97SU3, Streptococcus pyogenes, B8ZKP9, B1I8L7, Streptococcus gordonii, C1CAN1, B5E6H4, Streptococcus equi, Streptococcus Q04ML7, Q8E2B5, equi, Streptococcus equi, Q3K3V0, Q8E752, Streptococcus sanguinis, B9DSW9 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus uberis 1693 RLKTGTPPR Haemophilus ducreyi Q7VPP9 Q9Y2Z2 1694 RLKTGTPPRI Aeromonas salmonicida, Aeromonas A4STQ4, A0KQY9, Q9Y2Z2 hydrophila, Citrobacter koseri, A8ACP7, A4WGE6, Enterobacter sp., Haemophilus P44763, Q4QMT9, influenzae, Haemophilus influenzae, A5UHB8, Q0I5W4, Haemophilus influenzae, A5U9Q7, A6TG45 Haemophilus somnus, Haemophilus influenzae, Klebsiella pneumoniae 1695 RLLYVSCNP Pseudomonas syringae Q885Y8 Q8IZ69 1696 RLVLEVAQHLGE Rhizobium meliloti, Rhizobium sp., Q92LK8, C3M9S1, P06576 Rhizobium leguminosarum, Q1MAZ2, B3PQ68, Rhizobium etli, Rhizobium B5ZSN7, Q2K3H0, leguminosarum, Rhizobium etli, A5V3X5 Sphingomonas wittichii 1697 RMTGGGFGGC Haemophilus influenzae, P31767, A5UDQ5, P51570 Haemophilus influenzae, A5UHX0, B8F7C7 Haemophilus influenzae, Haemophilus parasuis 1698 RNIGIMAHIDAGKT Porphyromonas gingivalis, Q7MTL1, B2RLZ4 Q969S9 TT Porphyromonas gingivalis 1699 RNIGIMAHIDAGKT Micrococcus luteus P09952 Q969S9 TTTER 1700 RNIGIMAHIDAGKT Bacillus clausii, Bacillus halodurans, Q5WLR5, Q9Z9L7, Q969S9 TTTERIL Bifidobacterium longum, Q8G5B6, B3DT30, Bifidobacterium longum, B8DTV6, B8I5N7, Bifidobacterium animalis, Clostridium A1VEB9, Q72CI3 cellulolyticum, Desulfovibrio vulgaris, Desulfovibrio vulgaris 1701 RNIGIMAHIDAGKT Desulfovibrio vulgaris, Pediococcus B8DN94, Q03EB4, Q969S9 TTTERILYY ntosaceus, Staphylococcus Q4L3K8, Q5U859, haemolyticus, Staphylococcus B9DKV7, Q8CQ82, intermedius, Staphylococcus Q5HRK5, Q49V57, Scarnosus, Staphylococcus A6QEJ9, P68791, epidermidis, Staphylococcus P68790, Q6GBU0, epidermidis, Staphylococcus Q6GJC1, P68789, saprophyticus, Staphylococcus P68788, Q5HIC8, aureus, Staphylococcus aureus, Q2YSB4, A5IQA1, Staphylococcus aureus, Q2G0N1, Q2FJ93, Staphylococcus aureus, A6TZ24, A7WYX4 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1702 RNIGISAHID Acinetobacter baumannii, B0VTG3, B0V8Y3, Q96RP9 Acinetobacter baumannii, A3M306, B2HUQ4, Acinetobacter baumannii, B7I7S1, B7GYM8, Acinetobacter baumannii, Q6FDS6, A0KQ96, Acinetobacter baumannii, A8AQM8, C5BGM8, Acinetobacter baumannii, B7LS46, Q1R5U3, Acinetobacter baylyi, Aeromonas B6I240, B1LHE0, hydrophila, Citrobacter koseri, P0A6M8, B1IPV9, Edwardsiella ictaluri, Escherichia P0A6M9, Q0TCB9, fergusonii, Escherichia coli, A1AGM7, A8A5E7, Escherichia coli, Escherichia coli, C4ZUJ5, B1X6J0, Escherichia coli, Escherichia coli, B7M1P1, B7UK50, Escherichia coli, Escherichia coli, B7N0X6, B7NLP5, Escherichia coli, Escherichia coli, B5YTP7, P0A6N0, Escherichia coli, Escherichia coli, B7L4L1, B7MCV5, Escherichia coli, Escherichia coli, A7ZSL5, B7NDU8, Escherichia coli, Escherichia coli, P43925, A5U9R0, Escherichia coli, Escherichia coli, Q4QMT6, Q0I537, Escherichia coli, Escherichia coli, Q7VNA2, B8F7Z4, Escherichia coli, Escherichia coli, B4EYV7, Q8XV10, Haemophilus influenzae, Q8XRM7 Haemophilus influenzae, Haemophilus influenzae, Haemophilus somnus, Haemophilus ducreyi, Haemophilus parasuis, Proteus mirabilis, Ralstonia solanacearum, Ralstonia solanacearum 1703 RPRFGLLRGREF Bacillus pumilus, Bacillus clausii, A8FDC1, Q5WFT6, Q7L3T8 Bacillus licheniformis, Bacillus Q65JJ1, Q9KA71, halodurans, Bacillus subtilis, Bacillus O31755, A7Z4S8, methylotrophicus, Bacillus cereus, Q819Y4, B7HLF2, Bacillus cereus, Bacillus cereus, Q732Q0, B7HDU2, Bacillus cereus, Bacillus A9VT57, C1EP43, weihenstephanensis, Bacillus cereus, B7JJ97, C3L7A8, Bacillus cereus, Bacillus anthracis, C3P5M1, Q81WL6, Bacillus anthracis, Bacillus anthracis, A0RHJ2, Q6HEZ6, Bacillus thuringiensis, Bacillus Q636K7, B9IVA8, thuringiensis, Bacillus cereus, Bacillus B7IUH7, A7GRE9, cereus, Bacillus cereus, Bacillus Q044C3, Q74IS2, cytotoxicus, Lactobacillus gasseri, Q5FJN0, A8YVR3, Lactobacillus johnsonii, Lactobacillus A7I1R8, B8DG08, acidophilus, Lactobacillus helveticus, Q720A3, C1L2M5, Campylobacter hominis, Listeria Q8Y7G2, A0AIC0, monocytogenes, Listeria Q92C35, Q2YXK5, monocytogenes, Listeria Q6GHH2, Q5HGG8, monocytogenes, Listeria A8Z3U3, A6QGG3, monocytogenes, Listeria welshimeri, Q2FHH5, Q2G1Z4, Listeria innocua, Staphylococcus Q6G9V0, Q7A120, aureus, Staphylococcus aureus, Q7A5Y3, Q99UK9, Staphylococcus aureus, A7X1P3, A5ISE7, Staphylococcus aureus, A6U182, Q8C5T7, Staphylococcus aureus, Q5HPS8, Q4L5W5, Staphylococcus aureus, Q49X48 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus 1704 RPRGGDFLYS Rhizobium loti Q98L96 Q9NTM9 1705 RPWTIRQYAGFST Porphyromonas gingivalis Q59677 P22033 1706 RQPEFTQID Clostridium tetani Q892B2 Q6PI48 1707 RQTLLFSAT Escherichia coli, Pseudomonas P21693, Q88NB7, Q9UJV9 putida, Pseudomonas aeruginosa, Q9HXE5, B7UUT0, Pseudomonas aeruginosa, Q02S21, Q887N8 Pseudomonas aeruginosa, Pseudomonas syringae 1708 RQTLLFSATMP Lactobacillus reuteri, Listeria Q9Z6C9, Q8Y8N0, Q9UJV9 monocytogenes, Streptococcus P0A4D7, P0A4D8 pneumoniae, Streptococcus pneumoniae 1709 RRGRYVEFNL Aeromonas salmonicida, Aeromonas A45T50, A0KEX7, P36551 hydrophila, Enterobacter sp., A4WD41, B7M6U5, Escherichia coli, Escherichia coli, A7ZPN6, B1LMN0, Escherichia coli, Escherichia coli, B7N626, P36553, Escherichia coli, Escherichia coli, B1IWM6, A8A2T4, Escherichia coli, Escherichia coli, B1XAA7, C4ZX09, Escherichia coli, Escherichia coli, A1ADV0, Q8FFA3, Escherichia coli, Escherichia coli, Q0TF33, B7MY86, Escherichia coli, Escherichia coli, B7MHT7, B7UGD5, Escherichia coli, Escherichia coli, B7NPX2, B7LCI0, Escherichia coli, Escherichia B7LKJ9, B5YZY1, fergusonii, Escherichia coli, Q8XBI4, B6IS12, Escherichia coli, Escherichia coli, B5XVR1, A6TC68, Klebsiella pneumoniae, Klebsiella B4EZS7, Q3KKE0, pneumoniae, Proteus mirabilis, B0KF35, A5WVK4, Pseudomonas fluorescens, Q88RQ6, B1J4A2, Pseudomonas putida, Pseudomonas Q4KKQ4, A6UX86, putida, Pseudomonas putida, Q480H6, Q500S4, Pseudomonas putida, Pseudomonas B7VQ09, P43898, fluorescens, Pseudomonas Q02V57, Q1I2G6, aeruginosa, Pseudomonas Q88649, C3K4I0, savastanoi, Pseudomonas syringae, A4XNB8, Q8XXC3, Pseudomonas aeruginosa, B2U8Z4, B4SNL7, Pseudomonas aeruginosa, B2FND0 Pseudomonas aeruginosa, Pseudomonas entomophila, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas mendocina, Ralstonia solanacearum, Ralstonia pickettii, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1710 RRGRYVEFNLLYD Rhizobium leguminosarum, B5ZY73, B3PV29, P36551 RGT Rhizobium etli, Rhizobium Q1MDJ5, Q92PD8, leguminosarum, Rhizobium meliloti, Q2K5S3 Rhizobium etli 1711 RRLLYVSCNP Pseudomonas syringae, Q4ZQ44, Q48FH7 Q8IZ69 Pseudomonas savastanoi 1712 RRLQVQERLT Porphyromonas gingivalis, Q7MWI5, B2RIJ1 P30793 Porphyromonas gingivalis 1713 RRVLRPGGVL Pseudomonas aeruginosa A6UYW3 Q6UX53 1714 RRVVITGIG Rhizobium leguminosarum, P04684, P72331, Q9NWU1 Rhizobium sp., Streptomyces rimosus P43678 1715 RSAVSIARR Bacillus subtilis O31489 Q8N5C6 1716 RSPLWRGGG Desulfovibrio salexigens C6C186 Q9BYD3 1717 RTDAGVHAL Akkermansia muciniphila, B2UNB6, B2G8U7, Q8N0Z8 Lactobacillus reuteri, Lactobacillus A5VLH4, B2GDT8, reuteri, Lactobacillus fermentum, Q45557, Q03PY8, Bacillus sp., Lactobacillus brevis, B9M6W5, A5GB00, Geobacter daltonii, Geobacter B2U6Z1, Q8XXX8 uraniireducens, Ralstonia pickettii, Ralstonia solanacearum 1718 RTNTCGELR Porphyromonas gingivalis, B2RHE0, Q7MXM0 Q6PI48 Porphyromonas gingivalis 1719 RTSHYPYAEE Escherichia coli P05804 P08236 1720 RTTLLPGLL Geobacter metallireducens, Q39VS4, Q74CZ9, Q9NSD9 Geobacter sulfurreducens, Q828C6 Streptomyces avermitilis 1721 RVALIGDAAH Pseudomonas putida Q53552 Q9Y2Z9 1722 RVDFNVPMK Bacillus megaterium, Bacillus clausii, P24269, Q5WDK6, P07205 Bacillus licheniformis, Bacillus Q65EM9, A8FHJ3, pumilus, Bacillus cereus, Bacillus P62409, A7GUS0, cytotoxicus, Bacillus cereus, Bacillus Q631L9, P40924, subtilis, Bacillus cereus, Bacillus B7HW55, Q81X75, anthracis, Bacillus anthracis, Bacillus C3P0A6, C3LDI3, anthracis, Bacillus cereus, Bacillus B9J4M7, B7JFG6, cereus, Bacillus thuringiensis, Bacillus A0RKS6, C1EZA3, cereus, Bacillus thuringiensis, Bacillus Q6HBF0, B7IP23, cereus, Bacillus cereus, Bacillus B7HED5, A9VQ51, weihenstephanensis, Bacillus Q9K714, Q8Y4I2, halodurans, Listeria monocytogenes, B8DD98, Q928I0, Listeria monocytogenes, Listeria Q71WW8, C1KY97, innocua, Listeria monocytogenes, A0ALE2 Listeria monocytogenes, Listeria welshimeri 1723 RVEAFSDGV Streptomyces collinus S5VBU1 Q9BSA9 1724 RVEEMRQSL Pseudomonas fluorescens C3JY83 O75306 1725 RVGIGRPAH Bacillus clausii Q5WAD6 Q86Y79 1726 RVILQDFTGVP Streptococcus mutans Q59938 P21399 1727 RVILQDFTGVPAV Bacillus subtilis, Staphylococcus P09339, Q8CPC2, P21399 VD epidermidis, Staphylococcus Q5HPJ0, P63434, epidermidis, Staphylococcus aureus, Q6G9K9, P99148, Staphylococcus aureus, Q5HG69, P63433, Staphylococcus aureus, Q6GH55 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1728 RVLRLPAVA Haemophilus somnus, Neisseria Q0I5H4, Q9JWC5, O15067 meningitidis, Neisseria meningitidis, Q9JXK5, Q5F7J4 Neisseria gonorrhoeae 1729 RVRFAPSPTG Bacillus clausii, Geobacter lovleyi, Q5WLT5, B3E399, Q5JPH6 Porphyromonas gingivalis, B2RI67, Q7MUF7, Porphyromonas gingivalis, Uncultured B1H0J3 termite 1730 RVRIALALKG Pseudomonas aeruginosa P57109 O43708 1731 RVTVLGHVQRGG ptoclostridium difficile, Listeria Q180P4, A0AJ20, P17858 welshimeri, Listeria monocytogenes, Q8Y6W0, Q71Z96, Listeria monocytogenes, Listeria C1KVL8, B8DHH7, monocytogenes, Listeria Q92BE4 monocytogenes, Listeria innocua 1732 RVVDASIMP Klebsiella pneumoniae B5Y008 Q8NE62 1733 RYCINSAAL Lactobacillus salivarius, Bacillus Q1WVT3, A7Z5S1, Q8IXL7 methylotrophicus, Bacillus subtilis, P54155, Q9ZMK8, Helicobacter pylori, Helicobacter O25011, Q8XYL1, pylori, Ralstonia solanacearum, Q99ZV6, P0DC42, Streptococcus pyogenes, P0DC43, C0MDV8, Streptococcus pyogenes, Q8P172, Q5XCD0, Streptococcus pyogenes, C0M8H8, Q8E026, Streptococcus equi, Streptococcus Q3K1F5, Q8E5Q9, pyogenes, Streptococcus pyogenes, Q9LAM9 Streptococcus equi, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus gordonii 1734 RYLGDLSGGQV Corynebacterium diphtheriae P71119 P09601 1735 RYRQRYLDLI Arcobacter butzleri, Bacillus A8ESJ5, Q9KGG4, Q15046 halodurans, Bacillus clausii, Bacillus Q5WLU5, P37477, subtilis, Bacillus weihenstephanensis, A9VN90, B7ISY7, Bacillus cereus, Bacillus cereus, B7JK84, Q6HPU0, Bacillus thuringiensis, Bacillus cereus, Q63HC2, Q81VW3, Bacillus anthracis, Bacillus A0R8E9, Q81J70, thuringiensis, Bacillus cereus, Bacillus B7HJ16, B7HPY8, cereus, Bacillus cereus, Bacillus Q73FD1, A7GJY9, cereus, Bacillus cytotoxicus, A8AP96, A4WE42, Citrobacter koseri, Enterobacter sp., Q839A8, P0A8N6, Enterococcus faecalis, Escherichia P0A8N5, Q8FAT5, coli, Escherichia coli, Escherichia coli, P0A8N4, P0A8N3, Escherichia coli, Escherichia coli, Q8XD57, Q7VLU5, Escherichia coli, Haemophilus A5UIX4, Q4QL88, ducreyi, Haemophilus influenzae, A5UCQ0, P43825, Haemophilus influenzae, P56126, B2USI3, Haemophilus influenzae, B6JPT1, B5Z9V6, Haemophilus influenzae, Helicobacter Q17YS1, Q1CUX6, pylori, Helicobacter pylori, Q9ZMP8, Q92F47, Helicobacter pylori, Helicobacter Q8YAB8, Q724I4, pylori, Helicobacter acinonychis, A0AF28, Q8CQV5, Helicobacter pylori, Helicobacter Q5HRN7, Q4L3H5, pylori, Listeria innocua, Listeria Q53638, Q6GJF4, monocytogenes, Listeria P67609, P67610, monocytogenes, Listeria welshimeri, Q5HIF7, Q2YVW8, Staphylococcus epidermidis, Q2FJC3, Q2G0Q3, Staphylococcus epidermidis, A7WYS8, Q49V26, Staphylococcus haemolyticus, Q8NXZ0, Q6GBX1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus aureus, Staphylococcus aureus 1736 SAHGTNPASA Bacillus halodurans, Bacillus clausii, Q9K936, Q5WF32, P23378 Bacillus cereus, Bacillus P62029, A7Z6M2, methylotrophicus, Bacillus A7GSN6, A0RIK9, cytotoxicus, Bacillus thuringiensis, Q634V8, Q6HDT8, Bacillus cereus, Bacillus thuringiensis, C1ERU8, Q81M08, Bacillus cereus, Bacillus anthracis, C3P8D3, C3LKQ2, Bacillus anthracis, Bacillus anthracis, B7JMU9, B7HNY9, Bacillus cereus, Bacillus cereus, B9IXL7, B7IXL2, Bacillus cereus, Bacillus cereus, A9VH10, B7HB98, Bacillus weihenstephanensis, Bacillus P54377, Q818M5, cereus, Bacillus subtilis, Bacillus Q65HG1, A0AIF1, cereus, Bacillus licheniformis, Listeria Q8Y7D3, B8DFX8, welshimeri, Listeria monocytogenes, Q71ZX2, C1L2Q6, Listeria monocytogenes, Listeria Q92C04, Q49XX9, monocytogenes, Listeria Q4L6N5, Q2YSZ4, monocytogenes, Listeria innocua, Q8NWD0, A8Z474, Staphylococcus saprophyticus, Q6G931, Q2FY35, Staphylococcus haemolyticus, Q2FGI7, P99168, Staphylococcus aureus, P64219, A5IT63, Staphylococcus aureus, A7X2R9, A6U206, Staphylococcus aureus, Q6GGG4, A6QH79, Staphylococcus aureus, Q5HFM4, Q8CMM1, Staphylococcus aureus, Q5HP14 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1737 SCNIFSTQDH Desulfovibrio alaskensis, Q30WL8, A1VFZ7, P23526 Desulfovibrio vulgaris, Desulfovibrio Q72EH1, B8DR41, vulgaris, Desulfovibrio vulgaris, C6C1F4, P61617, Desulfovibrio salexigens, Geobacter Q98CM3 sulfurreducens, Rhizobium loti 1738 SCTTNCLAPLAKVI Enterobacter aerogenes P24163 O14556 1739 SDAFFPFRD Aeromonas salmonicida, Aeromonas A45R98, A0KGJ2, P31939 hydrophila, Citrobacter koseri, A8AKS0, Q0SV48, Clostridium perfringens, Clostridium Q0TTB0, Q8XMK2, perfringens, Clostridium perfringens, B2V3C3, B2TN76, Clostridium botulinum, Clostridium B7NRT9, B1XC09, botulinum, Escherichia coli, P15639, B1IUP1, Escherichia coli, Escherichia coli, C5A0U7, B7LAV3, Escherichia coli, Escherichia coli, B7LUJ6, B7NFU7, Escherichia coli, Escherichia B7MRD0, Q0TA59, fergusonii, Escherichia coli, B5Z0A3, Q8X611, Escherichia coli, Escherichia coli, B1LPG6, Q1R5X1, Escherichia coli, Escherichia coli, B7MIZ2, A1AIH7, Escherichia coli, Escherichia coli, B6I5L8, B7M7R5, Escherichia coli, Escherichia coli, A7ZUM3, A8A7A6, Escherichia coli, Escherichia coli, Q8FB68, B7UPG1, Escherichia coli, Escherichia coli, Q74FJ9, Q39RK1, Escherichia coli, Escherichia coli, A5G879, C6E5Z3, Geobacter sulfurreducens, Geobacter B5EBF9, B3E7F6, metallireducens, Geobacter B9M4Q6, Q0I557, uraniireducens, Geobacter sp., P43852, B5XYD2, Geobacter bemidjiensis, Geobacter A6TGR3, B4RP71, lovleyi, Geobacter daltonii, Q5F6T1, A9M4I2, Haemophilus somnus, Haemophilus Q9JZM7, B4EYT2, influenzae, Klebsiella pneumoniae, A4VPK9, Q87VR9, Klebsiella pneumoniae, Neisseria C3K6E0, A4XQ60, gonorrhoeae, Neisseria gonorrhoeae, Q9HUV9, B7V1R6, Neisseria meningitidis, Neisseria A6VCVV0, B1J5T3, meningitidis, Proteus mirabilis, Q02FG6, Q4KIX5, Pseudomonas stutzeri, Pseudomonas Q1I4C1, A5W9K7, syringae, Pseudomonas fluorescens, Q88DK3, B0KJZ6, Pseudomonas mendocina, Q8Y232, B2UFL5 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Ralstonia solanacearum, Ralstonia pickettii 1740 SDAYSTGSS Campylobacter concisus, A7ZC90, A7GXA8 P04424 Campylobactercurvus 1741 SDELNHASIIDGIR Bacillus methylotrophicus, Bacillus A7Z4X1, O31777, O75600 L subtilis, Bacillus pumilus A8FDG9 1742 SDELNHASL Corynebacterium kropnstedtii C4LK80 O15270 1743 SDGIMVARGDLG Methylobacterium extorquens O05118 P30613 1744 SDHIETLYE Geobacter bemidjiensis, Geobacter B5EJ44, C6E7U2, P22830 sp., Geobacter daltonii, Geobacter B9M326, A5GDG7 uraniireducens 1745 SDVANAVLDGAD Corynebacterium glutamicum Q46078 P30613 1746 SEDMLGRVF Clostridium novyi A0PZC7 P15313 1747 SEKETGDRN Clostridium perfringens Q8XIW8 Q9UI32 1748 SERIRTYNF Bacillus halodurans, Bacillus clausii, Q9K6F4, Q5WB55, O75570 Streptococcus pyogenes, P0DD95, P0DD94, Streptococcus pyogenes, B5XLI8, Q48TL0, Streptococcus pyogenes, Q99ZP5, Q8DU64, Streptococcus pyogenes, Q03L79, Q5M0B7, Streptococcus pyogenes, Q5M4W4, Q5XC69, Streptococcus mutans, Streptococcus Q3K1I9, A2REH9, thermophilus, Streptococcus Q1J6M1, Q1JGV2, thermophilus, Streptococcus Q1JLQ2, Q1JBR9, thermophilus, Streptococcus Q8DZM4, Q8E5C3, pyogenes, Streptococcus agalactiae, A3CN05, P47850, Streptococcus pyogenes, Q8P125 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus sanguinis, Streptococcus gordonii, Streptococcus pyogenes 1749 SEVMLQQTQVAT Escherichia coli, Haemophilus P17802, P44320 Q9UIF7 VI influenzae 1750 SFHSLEDRI Geobacter daltonii B9M164 A6NJ78 1751 SFHSLEDRIVK Geobacter sulfurreducens, Geobacter P60396, Q39YM7, A6NJ78 metallireducens, Geobacter A5G8K8, C6DZJ8, uraniireducens, Geobacter sp., B5EBP3, A4XQR6, Geobacter bemidjiensis, Q02H20, Q9HVZ5, Pseudomonas mendocina, B7UZJ8, A6VB93, Pseudomonas aeruginosa, Q1I5130, B0KFT4, Pseudomonas aeruginosa, A5W8Q8, Q88N84, Pseudomonas aeruginosa, B1J1Y2 Pseudomonas aeruginosa, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida 1752 SFITPVPGGVGPM Campylobacter hominis, A7I254, A7GXK2 P11586 T Campylobacter curvus 1753 SFTGSTQVG Pseudomonas putida P43503 P49419 1754 SFTKGCYIGQE Haemophilus influenzae P44000 Q5T440 1755 SGAGGQHVN Lactobacillus reuteri, Lactobacillus B2G676, B3WDK7, Q9UGC7 casei, Lactobacillus casei, Q03A29, Q4K695, Pseudomonas fluorescens, Q48MV4, Q4ZXW7, Pseudomonas savastanoi, P42806, B7V0L1, Pseudomonas syringae, Q02G09, C3KDC6, Pseudomonas aeruginosa, A6VC61, B4SKS8, Pseudomonas aeruginosa, B2FQ14 Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1756 SGAGGQHVNTTD Citrobacter koseri, Edwardsiella A8AG02, C5B814, Q9UGC7 SA ictaluri, Enterobacter sp., Escherichia A4WBC6, B7UQ99, coli, Escherichia fergusonii, B7LSH9, B619S6, Escherichia coli, Escherichia coli, B1LH89, Q1RCM7, Escherichia coli, Escherichia coli, B1IU82, B7N422, Escherichia coli, Escherichia coli, P0A7I0, A1AAD8, Escherichia coli, Escherichia coli, P0A7I1, A7ZZE7, Escherichia coli, Escherichia coli, Q0TIF9, P0A7I2, Escherichia coli, Escherichia coli, B1XAQ2, C4ZTQ2, Escherichia coli, Escherichia coli, B7LXC6, B5YXM9, Escherichia coli, Escherichia coli, B7NUX7, A7ZKY5, Escherichia coli, Escherichia coli, B7LGX2, B7MKB3, Escherichia coli, Escherichia coli, B7MTZ5, A6TAN9, Klebsiella pneumoniae, Proteus B4EVR7, A4XR61, mirabilis, Pseudomonas mendocina, Q3K6W9 Pseudomonas fluorescens 1757 SGAGGQHVNTTD Geobacter lovleyi, Geobacter B3E628, A5G8T7, Q9UGC7 SAVRI uraniireducens, Staphylococcus Q4L7Z9, Q5HMA4, haemolyticus, Staphylococcus Q8CNI7, Q6GEV7, epidermidis, Staphylococcus Q2YUN5, A8YY83, epidermidis, Staphylococcus aureus, P66020, Q6G7J2, Staphylococcus aureus, P66019, P66018, Staphylococcus aureus, A6QIW2, Q5HE82, Staphylococcus aureus, Q2FF10, A5IUR3, Staphylococcus aureus, Q2FWE0, A6U3K3, Staphylococcus aureus, A7X4W4, Q49Z65 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus 1758 SGAGKSSLI Acinetobacter baylyi Q6FAN3 Q6NXR0 1759 SGAGKSSLL Escherichia coli, Escherichia coli, P0AAF7, P0AAF6, Q8N139 Escherichia coli, Pseudomonas P0AAF8, Q1IGN4, entomophila, Pseudomonas putida Q88RB3 1760 SGAGKSTLLN Haemophilus ducreyi Q7VP69 Q94911 1761 SGAGKSTLM Fusobacterium nucleatum Q8REG7 P45844 1762 SGAHLNPAV Pseudomonas aeruginosa Q51389 P29972 1763 SGAHLNPAVT Escherichia coli, Escherichia coli, P0AER0, P0AER1, P29972 Escherichia coli, Haemophilus P0AER2, P44826, influenzae, Streptomyces coelicolor P19255 1764 SGDLAPLSH Streptomyces avermitilis, Q82I33, P24221, P42357 Streptomyces griseus, Streptomyces Q9EWW1 coelicolor 1765 SGEPMDKAG Clostridium perfringens, Clostridium Q0SR36, Q0TNG7, O95671 perfringens, Clostridium perfringens, Q8XIH4, Q9K0J8, Neisseria meningitidis, Neisseria Q9JVK3 meningitidis 1766 SGFPKNRVIG Bacillus clausii, Bacillus halodurans, Q5WEG2, Q9K849, P00338 Fusobacterium nucleatum Q8RED8 1767 SGGGSGHEPAH Citrobacter freundii P45510 Q3LXA3 1768 SGGPNSVYA Streptococcus equi, Streptococcus C0MAM2, P64299, P49915 pyogenes, Streptococcus pyogenes, B5XLN9, Q1J6G5, Streptococcus pyogenes, P64300, Q48TF6, Streptococcus pyogenes, Q1JGP6, Q5XC20, Streptococcus pyogenes, C0MFC7, P0DB55, Streptococcus pyogenes, P0DB54, Q1JBM8, Streptococcus pyogenes, Q1JLL1, A2RED2, Streptococcus equi, Streptococcus Q8DZX7, Q8E5M8, pyogenes, Streptococcus pyogenes, Q3K1C0, B9DUB2 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus uberis 1769 SGGPNSVYAEDA Streptococcus thermophilus, Q5M4P4, Q5M029 P49915 Streptococcus thermophilus 1770 SGGQKQRIA Leuconostoc mesenteroides Q10418 Q9NRK6 1771 SGGQKQRISLAR Escherichia coli Q9X2W0 Q96J66 1772 SGHKIYGPKG Edwardsiella ictaluri C5BEU5 Q9Y697 1773 SGHWEHYQEDMF Streptococcus uberis, Streptococcus B9DU13, A3CP56, Q9BW92 sanguinis, Streptococcus equi C0MCN7 1774 SGIGRAVSV Bacillus subtilis, Bacillus subtilis P80873, P40397 Q92506 1775 SGILVQLPLP Helicobacter pylori Q9ZLQ4 Q9H903 1776 SGKGGVGKS Bacillus subtilis, Escherichia coli, P40742, P0AF09, P53384 Escherichia coli, Haemophilus P0AF08, P45135, influenzae, Helicobacter pylori O25678 1777 SGKGGVGKST Bacillus subtilis, Clostridium P50863, P53381, P53384 perfringens, Helicobacter pylori, O24999, Q9ZMM5, Helicobacter pylori, Helicobacter O25098, Q9ZMA8, pylori, Helicobacter pylori, P72190 Pseudomonas fragi 1778 SGLRGRGGAGFP Desulfovibrio fructosivorans, Q46507, Q9XAQ9 P49821 TG Streptomyces coelicolor 1779 SGLRGRGGAGFP Rhizobium meliloti P56912 P49821 TGLKWSFM 1780 SGLRLGTPA Staphylococcus carnosus, B9DMF3, B4SJB0, P34896 Stenotrophomonas maltophilia, B2FNK2 Stenotrophomonas maltophilia 1781 SGLRLGTPALT Campylobacter jejuni, Campylobacter A7H4X6, Q5HW65, P34896 jejuni, Campylobacter jejuni, A8FKI9, P24531, Campylobacter jejuni, Campylobacter A1VYC2 jejuni 1782 SGPLVRSSY Corynebacterium urealyticum, B1VHG8, Q4JWE0, O43766 Corynebacterium jeikeium, C3PHK6, Q8FNP4, Corynebacterium aurimucosum, Q9S2P2 Corynebacterium efficiens, Streptomyces coelicolor 1783 SGPSGAGKST Fusobacterium nucleatum Q8RHI9 Q16774 1784 SGPSGAGKSTLLK Campylobacter jejuni, Campylobacter Q5HTT7, Q9PNB8 Q16774 jejuni 1785 SGSGKTTLL Bacillus subtilis, Bacillus subtilis, O34697, P42423, Q9H222 Bacillus halodurans, Haemophilus Q9K619, Q57213, influenzae, Pseudomonas Q3KCC5, Q92VJ2, fluorescens, Rhizobium meliloti, Q98K23, Q92XW1 Rhizobium loti, Rhizobium meliloti 1786 SGTDGVGTK Finegoldia magna B0S0R2 P22102 1787 SGTDGVGTKL Acinetobacter baumannii, B0VT70, B2HWV2, P22102 Acinetobacter baumannii, A3M7X8, B0VDJ1, Acinetobacter baumannii, B7GY98, B7I5C6, Acinetobacter baumannii, Q6F973, A0KM24, Acinetobacter baumannii, A4SL28, Q1G9G0, Acinetobacter baumannii, Q049L9, Q1WU57, Acinetobacter baylyi, Aeromonas Q9KF55, Q5FIV3, hydrophila, Aeromonas salmonicida, Q5WJ84, A8YW83, Lactobacillus delbrueckii, B2GF76, Q6HPA2, Lactobacillus delbrueckii, A0R8Z8, C1EV65, Lactobacillus salivarius, Bacillus B7JM87, Q81ZH0, halodurans, Lactobacillus acidophilus, C3L534, C3PBN2, Bacillus clausii, Lactobacillus A9VRF3, B9J1K7, helveticus, Lactobacillus fermentum, Q73EN3, A7GKI0, Bacillus thuringiensis, Bacillus B7HS34, B7IUV5, thuringiensis, Bacillus cereus, Bacillus Q63GT1, B7H4T8, cereus, Bacillus anthracis, Bacillus Q81IQ1, A5VHU0, anthracis, Bacillus anthracis, Bacillus B2G5C0, B3DT56, weihenstephanensis, Bacillus cereus, Q8G595, B7GU81, Bacillus cereus, Bacillus cytotoxicus, A1A0R8, B8DTT6, Bacillus cereus, Bacillus cereus, C3L2V1, Q97J93, Bacillus cereus, Bacillus cereus, A7GH98, B1IL59, Bacillus cereus, Lactobacillus reuteri, C1FV78, A7FXD5, Lactobacillus reuteri, Bifidobacterium B1KZ57, C5BHQ4, longum, Bifidobacterium longum, A4WD72, Q833Z1, Bifidobacterium longum, B7LKE3, B6I571, Bifidobacterium adolescentis, Q1R8N9, B7MHY0, Bifidobacterium animalis, Clostridium B7MYC7, Q8XAC5, botulinum, Clostridium B5Z036, B1IWG1, acetobutylicum, Clostridium A8A2Z1, Q8FF72, botulinum, Clostridium botulinum, B7M7K3, B7N681, Clostridium botulinum, Clostridium B1LNF0, B7LCN9, botulinum, Clostridium botulinum, Q0TEY9, P08178, Edwardsiella ictaluri, Enterobacter C4ZX74, B1XAX4, sp., Enterococcus faecalis, A7ZPU2, B7UGN7, Escherichia fergusonii, Escherichia B7NQN8, A5UC39, coli, Escherichia coli, Escherichia coli, A5UEU3, P43848, Escherichia coli, Escherichia coli, Q4QKF3, Q0I5D1, Escherichia coli, Escherichia coli, B8F5E6, A6TCB3, Escherichia coli, Escherichia coli, B5XNQ0, A0AJM1, Escherichia coli, Escherichia coli, Q71YQ1, C1KW66, Escherichia coli, Escherichia coli, B8DDZ0, Q92AP1, Escherichia coli, Escherichia coli, Q8Y6C3, B4EY89, Escherichia coli, Escherichia coli, A4XWN5, Q48FI4, Escherichia coli, Escherichia coli, Q4K8A5, B0KT52, Escherichia coli, Haemophilus A5W7R7, Q88MA9, influenzae, Haemophilus influenzae, Q4ZQ51, Q885Y1, Haemophilus influenzae, B1J1M3, C3K102, Haemophilus influenzae, Q1IDL2, Q3KFT0, Haemophilus somnus, Haemophilus Q9I513, B7UXY9, parasuis, Klebsiella pneumoniae, Q02IA6, Q9F1T6, Klebsiella pneumoniae, Listeria C1CNS6, B2IR37, welshimeri, Listeria monocytogenes, Q97TA2, C1CBM4, Listeria monocytogenes, Listeria B8ZJN0, C1C9V1, monocytogenes, Listeria innocua, B1I7V5, Q9A1Z0, Listeria monocytogenes, Proteus Q8E7W9, Q8DRM4, mirabilis, Pseudomonas mendocina, Q04N22, C1CHV9, Pseudomonas savastanoi, Q8E2G1, A2RBZ5, Pseudomonas fluorescens, Q3K400, Q5XEF4, Pseudomonas putida, Pseudomonas Q1J936, Q8P312, putida, Pseudomonas putida, B5XJ18, P0DD63, Pseudomonas syringae, P0DD62, B5E5J6, Pseudomonas syringae, Q1JJ82, Q1JE80, Pseudomonas putida, Pseudomonas Q48VX3, A8AU99, fluorescens, Pseudomonas A3CJZ4, B9DSR4, entomophila, Pseudomonas Q1JP36, Q8DWL1, fluorescens, Pseudomonas Q5M203, Q5M6J5, aeruginosa, Pseudomonas Q03MZ8 aeruginosa, Pseudomonas aeruginosa, Streptococcus suis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus gordonii, Streptococcus sanguinis, Streptococcus uberis, Streptococcus pyogenes, Streptococcus mutans, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus 1788 SGTDGVGTKLK Bacillus subtilis, Bacillus pumilus, P12043, A8FAM9, P22102 Bacillus methylotrophicus, Bacillus A7Z251, Q65MS6, licheniformis, Desulfitobacterium B8FP03, Q24QH4, hafniense, Desulfitobacterium A9KHX3, B3E3K3, hafniense, Clostridium B5EFU7, C6E6M9, phytofermentans, Geobacter lovleyi, Q9JUA2, A9LZD2, Geobacter bemidjiensis, Geobacter A1KU60, Q5F973, sp., Neisseria meningitidis, Neisseria Q9JZ80, Q8XW52, meningitidis, Neisseria meningitidis, Q49WJ5, Q4L580, Neisseria gonorrhoeae, Neisseria Q5HQ99, Q8CT29, meningitidis, Ralstonia solanacearum, Q2YX52, Q5HH13, Staphylococcus saprophyticus, A8Z1L3, Q2FI07, Staphylococcus haemolyticus, Q2FZI8, A6QFS9, Staphylococcus epidermidis, A6U0N9, P67721, Staphylococcus epidermidis, P99163, A5IRV8, Staphylococcus aureus, A7X0W4, Q8NX90, Staphylococcus aureus, Q6GAE2, Q6GI13, Staphylococcus aureus, B9DQ40, B45N29, Staphylococcus aureus, B2FRX8 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus carnosus, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1789 SGTDGVGTKLKIA Clostridium kluyveri, Clostridium B9E4K8, A5N0Q2, P22102 kluyveri, Clostridium cellulolyticum, B8I492, A0Q1J2, Clostridium novyi, Clostridium A3DEV1, Q74CB6, thermocellum, Geobacter B9M1P4, A5G3H3, sulfurreducens, Geobacter daltonii, Q39UK1 Geobacter uraniireducens, Geobacter metallireducens 1790 SGVGKSSLV Bacteroides thetaiotaomicron Q8A8H7 Q5HYI8 1791 SGWDFSSRW Citrobacter koseri, Escherichia coli, A8AFT6, Q0TIH3, O43280 Escherichia coli, Escherichia coli, B7UQ86, B1LHA4, Escherichia coli, Escherichia coli, B7NUW3, B619Q8, Escherichia coli, Escherichia coli, P13482, B1IU96, Escherichia coli, Escherichia coli, A7ZZD1, B1XAN8, Escherichia coli, Escherichia coli, C4ZTN8, B7N408, Escherichia coli, Escherichia coli, Q8CVV46, B7LGV7, Escherichia coli, Escherichia coli, Q1RCP3, B7MK99, Escherichia coli, Escherichia coli, A7ZKW9, A1AAC5, Escherichia coli, Escherichia coli Q8XDH7, B7LXB1 1792 SIPVIANGDI Escherichia coli, Escherichia coli, P0ABT5, P0ABT6, O95620 Escherichia coli, Klebsiella P0ABT7, O52536 pneumoniae 1793 SIRDVIAFPK Bifidobacterium longum, Q8G863, B7GPT0, Q6PI48 Bifidobacterium longum, B3DPM0 Bifidobacterium longum 1794 SIWAPSQTL Bacillus subtilis, Bacillus halodurans P18185, Q9K8V7 P27708 1795 SKAGVIGLT Clostridium scindens P07914 Q92506 1796 SKKARDGKL Escherichia coli P06959 O00330 1797 SKPGEPSWP Edwardsiella ictaluri C5B8V6 P49589 1798 SKPLKGARI Bacteroides fragilis, Bacteroides Q64MT2, Q8A407 P23526 thetaiotaomicron 1799 SLKKLQLDY Escherichia coli, Escherichia coli Q46857, Q8XBT6 P17516 1800 SLLGGGGVDG Citrobacter koseri, Klebsiella variicola, A8AI35, D3RKJ0, Q9BQ69 Klebsiella pneumoniae B5XXK9 1801 SLNVSVAAG Acinetobacter baylyi Q6FF50 Q6IN84 1802 SLPNSRIMIHQP Helicobacter hepaticus Q7VIN7 Q16740 1803 SLWPMTFGLACC Bacillus weihenstephanensis, Bacillus A9VS97, Q6HAY6, O75251 A thuringiensis, Bacillus cereus, Bacillus Q630U9, A0RL90, thuringiensis, Bacillus cereus, Bacillus B9IRT1, Q81K01, anthracis, Bacillus cereus, Bacillus Q814W7, C3P1E8, anthracis, Bacillus cereus, Bacillus C1F0M2, B7HY57, cereus, Bacillus cereus, Bacillus B7HFJ5, C3LFH3, anthracis, Bacillus cereus, Bacillus Q72XF4, B7JGM4, cereus, Bacillus cereus, Bacillus B7IQV2, A7GV50, cytotoxicus, Desulfovibrio vulgaris B8DS03 1804 SLWPMTFGLACC Ralstonia solanacearum, Ralstonia Q8XXQ2, B2U7R0 O75251 AVEMMH pickettii 1805 SMCEHHLVPF Bacillus methylotrophicus, Bacillus A7Z630, A8FEL2, P30793 pumilus, Bacillus subtilis, Bacillus P19465, A7GN48, cytotoxicus, Bacillus A9VMC0, B9IVN3, weihenstephanensis, Bacillus cereus, Q6HL44, Q63DM1, Bacillus thuringiensis, Bacillus cereus, Q81FQ8, C1EN08, Bacillus cereus, Bacillus cereus, B7HL21, Q73AY4, Bacillus cereus, Bacillus cereus, B7HHR5, B7IP89, Bacillus cereus, Bacillus cereus, B7JGZ6, Q81SW2, Bacillus cereus, Bacillus anthracis, C3L8S8, C3P598, Bacillus anthracis, Bacillus anthracis, A0RBW5, Q8XLM2, Bacillus thuringiensis, Clostridium Q0STY9, Q0TRM0, perfringens, Clostridium perfringens, Q8NM84, A4QH94, Clostridium perfringens, Q71Y82, C1KWN3, Corynebacterium glutamicum, Q8Y5X1, Q92A75, Corynebacterium glutamicum, Listeria B8DBZ3, A0AK45, monocytogenes, Listeria Q5LYM8, Q5M391, monocytogenes, Listeria Q8DZI5, Q3K0Y1, monocytogenes, Listeria innocua, Q8E549, A4W1S9, Listeria monocytogenes, Listeria A4WH1, Q8DUG2 welshimeri, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus suis, Streptococcus suis, Streptococcus mutans 1806 SMRIMTRMG Corynebacterium diphtheriae, Q6NET5, C4LGT5, P35558 Corynebacterium kropnstedtii, Q8FM16, Q4JY04, Corynebacterium efficiens, A4QHQ4, Q9AEM1 Corynebacterium jeikeium, Corynebacterium glutamicum, Corynebacterium glutamicum 1807 SNASCTTNC Staphylococcus epidermidis, Q8CNY0, Q5HNL7, O14556 Staphylococcus epidermidis, Q6GG19, Q6G8N9, Staphylococcus aureus, P64181, P99067, Staphylococcus aureus, P64180, Q5HF86 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1808 SNASDALDK Desulfovibrio vulgaris, Desulfovibrio Q728G0, Q313E8, P14625 alaskensis, Streptomyces coelicolor P58481 1809 SNHGGRQLD Pseudomonas putida P20932 Q9NYQ3 1810 SNPVDILTY Corynebacterium glutamicum, Q8NLN0, A4QHW5, Q9BYZ2 Corynebacterium glutamicum, P62050, Q92F65, Corynebacterium diphtheriae, Listeria Q724K3, P33380 innocua, Listeria monocytogenes, Listeria monocytogenes 1811 SPAEKAGLQ Haemophilus influenzae P44936 Q5T2W1 1812 SPCGACRQV Bacillus subtilis P19079 P32320 1813 SPDKDVDGFH Neisseria meningitidis, Neisseria P0C277, Q9JWI9, P13995 meningitidis, Neisseria meningitidis, A9M068, A1KWF4, Neisseria meningitidis, Neisseria B4RQN5, Q5F5D0 gonorrhoeae, Neisseria gonorrhoeae 1814 SPNGKLRLL Geobacter lovleyi, Geobacter B3E2M3, Q39UC4, P09467 metallireducens, Geobacter A5G439 uraniireducens 1815 SPRFRGEHALRR Methylobacterium sp., B0ULL2, B8IUV4, O00217 YP Methylobacterium nodulans, Q92QP4, Q98KR4 Rhizobium meliloti, Rhizobium loti 1816 SPRQSDVMI Rhizobium etli, Rhizobium etli, B3PY57, Q2K3U4, O75251 Rhizobium meliloti P56897 1817 SQGRLESLLN Pseudomonas savastanoi, Q48ME3, Q4ZXH2, P23378 Pseudomonas syringae, Q887L5 Pseudomonas syringae 1818 SQSGETADTL Bacteroides thetaiotaomicron, Q8AAB1, Q890U2, Q06210 Clostridium tetani, Geobacter Q74GH6, Q98LX5, sulfurreducens, Rhizobium loti, P08633, Q92ZK3, Rhizobium leguminosarum, Q92P54, P25195 Rhizobium meliloti, Rhizobium meliloti, Rhizobium meliloti 1819 SQSSNDTFPTAM Campylobacter jejuni O69294 P07954 1820 SQWGHDFRP Bacillus subtilis O34748 P46063 1821 SRHPFPGPGLAIR Arcobacter butzleri A8ETA7 P49915 1822 SRQRYWGTPIPI Sphingomonas wittichii A5VA89 Q15031 1823 SRTDAGVHAL Bacillus cereus, Bacillus cereus, Q63GF1, Q73E17, Q8N0Z8 Bacillus anthracis, Bacillus Q6I3T8, Q6HNW5, thuringiensis, Bacillus cereus Q813Z9 1824 SRTRVKTLA Propionibacterium acnes Q6AAI8 P46926 1825 SRVALVTGA Streptomyces cinnamonensis P41177 O75828 1826 SSGSACTSA Acinetobacter baumannii, B0VD51, B7H3H0, Q9Y697 Acinetobacter baumannii, B2HZI5, B715Q3, Acinetobacter baumannii, B0VNW2 Acinetobacter baumannii, Acinetobacter baumannii 1827 SSGSACTSASLEP Haemophilus parasuis, Haemophilus B8F356, Q0I1L2, Q9Y697 SYVLRA somnus,, Haemophilus influenzae, Q57337, A5UGI1, Haemophilus influenzae, A5UAA8, A9M029, Haemophilus influenzae, Neisseria A1KUK1, Q9JTX0, meningitidis, Neisseria meningitidis, B4RMB8, Q5F8X4, Neisseria meningitidis, Neisseria A4VNY2, B7UWH7, gonorrhoeae, Neisseria gonorrhoeae, Q9HXI8, Q02RW8, Pseudomonas stutzeri, Pseudomonas A4XY43, A6V0U8, aeruginosa, Pseudomonas Q3K7A5, C3K1M5, aeruginosa, Pseudomonas Q4K6T8 aeruginosa, Pseudomonas mendocina, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas fluorescens 1828 SSGSACTSASLEP Haemophilus ducreyi Q7VMA9 Q9Y697 SYVLRAIG 1829 SSPNTAGLR Stenotrophomonas maltophilia, B2FPI7, B4STK4 Q02127 Stenotrophomonas maltophilia 1830 SSRTDAGVHA Clostridium kluyveri, Clostridium A5N4T0, A6LPU5 Q8N0Z8 beijerinckii 1831 SSRTDAGVHAL Clostridium tetani Q890R5 Q8N0Z8 1832 STGGGASLE Bifidobacterium longum, B7GQU7, B3DRV9, P07205 Bifidobacterium longum, Q8G6D6, Q4JVJ3, Bifidobacterium longum, A4QEG1, Q01655, Corynebacterium jeikeium, B1VDQ4, C3PG40, Corynebacterium glutamicum, Q8FT66, C5CBP5 Corynebacterium glutamicum, Corynebacterium urealyticum, Corynebacterium aurimucosum, Corynebacterium efficiens, Micrococcus luteus 1833 STGGGASLEL Arcobacter butzleri, Campylobacter A8EWM4, A7GWT1, P07205 curvus, Campylobacter concisus, A7ZEZ5, Q5HT15, Campylobacter jejuni, Campylobacter A8FN77, Q9PMQ5, jejuni, Campylobacter jejuni, A1W116, A0RQT4, Campylobacter jejuni, Campylobacter A7I1G1, A7H5C5, fetus, Campylobacter hominis, C4LIR6 Campylobacter jejuni, Corynebacterium kropnstedtii 1834 STGGGASLELLEG Corynebacterium diphtheriae, P62411, B8J4D3 P07205 K Desulfovibrio desulfuricans 1835 STGGGASLELLEG Helicobacter hepaticus, Helicobacter Q7VJB6, P56154, P07205 KILP pylori, Helicobacter pylori Q9ZJP1 836 STGVPHILEH Clostridium perfringens Q46205 Q5JRX3 1837 STNHKDIGTLYL Rhizobium leguminosarum Q08855 P00395 1838 SVAFDLATHRGYD Rhizobium meliloti O86028 P22033 SD 1839 SVFAGVGERTRE Acinetobacter baylyi, Acinetobacter Q6FFK0, A3M144, P06576 GND baumannii, Acinetobacter baumannii, B0VNK4, B0VBP3, Acinetobacter baumannii, B7H294, B7I1W4, Acinetobacter baumannii, B2II02, A1KW11, Acinetobacter baumannii, A9M123, Q9JW70, Acinetobacter baumannii, Neisseria Q9JXQ2, B2FHY8, meningitidis, Neisseria meningitidis, B4SJR9 Neisseria meningitidis, Neisseria meningitidis, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1840 SVFAGVGERTRE Desulfitobacterium hafniense, Q24MP1, B8FZ34 P06576 GNDL Desulfitobacterium hafniense 1841 SVLEMSHRS Streptococcus suis, Streptococcus A4VU42, A4W0D4, Q9Y617 suis, Streptococcus uberis, B9DTW4, Q03JH6, Streptococcus thermophilus, Q5LYP0, Q5M3A4 Streptococcus thermophilus, Streptococcus thermophilus 1842 SVLFVCLGNICRS Bacillus subtilis Q35016 P24666 P 1843 SVSDKTGLV Lactobacillus casei, Lactobacillus B3WF93, Q037V3, P31939 casei, Leuconostoc citreum B1MY42 1844 SVSDKTGLVE Stenotrophomonas maltophilia, B45L92, B2FJP9 P31939 Stenotrophomonas maltophilia 1845 SVVGTSSLRR Enterobacter sp., Klebsiella A4WG12, A6TGI8, P08397 pneumoniae, Klebsiella pneumoniae, B5XYL1, B4F1X3, Proteus mirabilis, Proteus mirabilis, Q59684, Q1I316, Pseudomonas entomophila, Q4K3X3, Q02EA3, Pseudomonas fluorescens, B7V5F0, Q60169, Pseudomonas aeruginosa, A6VE37 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa 1846 SYAAVPLYR Rhizobium etli, Rhizobium Q2KBM0, B5ZSV4, Q9Y6N1 leguminosarum, Rhizobium Q1MKI3, B3PSB4 leguminosarum, Rhizobium etli 1847 SYEARAFGV Rhizobium loti, Rhizobium loti, Q98NW7, Q98JM5, Q9Y253 Streptococcus pneumoniae, Q975C7, Q8DQZ7, Streptococcus pneumoniae, Q04M21 Streptococcus pneumoniae 1848 TAARGRGKS Citrobacter koseri, Escherichia coli A8ADB3, P76562 Q9H0A0 1849 TAMTGDGVND Streptococcus pneumoniae P35597 O14983 1850 TAVLIETLV Acinetobacter baylyi, Q6FA43, P61456, P23526 Corynebacterium diphtheriae, Q4ZZ92, Q4K4H7, Pseudomonas syringae, Q3K5D7, B0KMQ0, Pseudomonas fluorescens, Q48PB5, Q87V73, Pseudomonas fluorescens, Q1I3W5, A5WA09, Pseudomonas putida, Pseudomonas B1J2Y8, C3K3G6, savastanoi, Pseudomonas syringae, B5ZV80, Q1MNC6, Pseudomonas entomophila, Q2KE72, B3PVW2, Pseudomonas putida, Pseudomonas Q8GGL7, Q82DC9, putida, Pseudomonas fluorescens, B1VUW6, Q9KZM1, Rhizobium leguminosarum, Q936D6 Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli, Streptomyces atroolivaceus, Streptomyces avermitilis, Streptomyces griseus, Streptomyces coelicolor, Streptomyces argillaceus 1851 TDGERILGLGD Acinetobacter baylyi Q6FFL8 P48163 1852 TDGVGTKLK Desulfovibrio vulgaris, Desulfovibrio B8DNV5, Q311C7 P22102 alaskensis 1853 TDKTGTLTQ Escherichia coli, Escherichia coli P0ABB8, P0ABB9 O43861 1854 TDTVVISMGQ Sphingomonas wittichii A5V656 P00480 1855 TDTVVISMGQE Campylobacter hominis A7I3W8 P00480 1856 TDVTNASRT Corynebacterium efficiens, Q8FLY8, B1LWN6 Q14409 Methylobacterium radiotolerans 1857 TDVTNASRTML Streptomyces avermitilis, Q828K5, Q9ADA7 Q14409 Streptomyces coelicolor 1858 TDVTNASRTMLFN Parabacteroides distasonis A6LCZ1 Q14409 I 1859 TDVTNASRTMLFN Lactobacillus reuteri, Lactobacillus B2G7U6, A5VKE8 Q14409 IH reuteri 1860 TEGCRGEGG Escherichia coli, Escherichia coli, P0AC41, P0AC42, P31040 Escherichia coli P0AC43 1861 TEGCRGEGGIL Escherichia coli, Haemophilus P00363, P44894, P31040 influenzae, Proteus vulgaris P20922 1862 TEPGAGSDV Citrobacter koseri, Escherichia A8ALR4, B7LWN0, P11310 fergusonii, Escherichia coli, Q1RGF9, B1LFX2, Escherichia coli, Escherichia coli, B6HYZ0, P60584, Escherichia coli, Escherichia coli, B7N7R4, A7ZVY9, Escherichia coli, Escherichia coli, A1A789, C4ZPW5, Escherichia coli, Escherichia coli, B1XBG4, B7NHE3, Escherichia coli, Escherichia coli, B7MNP6, B5YYD3, Escherichia coli, Escherichia coli, B7L4G2, B7UI85, Escherichia coli, Escherichia coli, P60586, B7MAG2, Escherichia coli, Escherichia coli, A7ZHD0, B7M0D6, Escherichia coli, Escherichia coli, Q0TLV0, Q8GB20, Proteus sp., Proteus mirabilis B4EY23 1863 TERVLYYTG Rhizobium loti Q98N59 Q96RP9 1864 TFDSGGISIK Aeromonas hydrophila, Aeromonas A0KPF3, A4SSA7, P28838 salmonicida, Citrobacter koseri, A8AMA5, A4WF25, Enterobacter sp., Escherichia coli, B6I2H3, Q1R2Z4, Escherichia coli, Escherichia coli, B1LRE5, B7NGJ2, Escherichia coli, Escherichia coli, P68767, P68766, Escherichia coli, Escherichia coli, B1ISB1, A1AJG3, Escherichia coli, Escherichia coli, A8A816, Q0T9D1, Escherichia coli, Escherichia coli, B7M9L9, B1XEN9, Escherichia coli, Escherichia coli, C4ZRD1, B7NUH4, Escherichia coli, Escherichia coli, B7MSZ3, B7LCX0, Escherichia coli, Escherichia coli, B5Z3L7, B7MLR5, Escherichia coli, Escherichia coli, P68768, A7ZVE0, Escherichia coli, Escherichia coli, B7UQR7, B7LMT2, Escherichia fergusonii, Klebsiella B5Y2T8, A6THI2, pneumoniae, Klebsiella pneumoniae, B4F2N1 Proteus mirabilis 1865 TFGCGSAIASSS Klebsiella pneumoniae P05343 Q9H1K1 1866 TFGFRGEAL Clostridium novyi A0QQM7 P54278 1867 TFGGNPMACA Neisseria meningitidis, Neisseria Q9JTX9, Q9JYY4 Q9BYV1 meningitidis 1868 TFGLACCAVEMM Neisseria meningitidis, Neisseria Q9K1C2, A1KRS3, O75251 H meningitidis, Neisseria gonorrhoeae, B4RPI3, Q5F616, Neisseria gonorrhoeae, Neisseria A1INN9 meningitidis 1869 TFGPTFRAE Fusobacterium nucleatum, Q8RH70, A5N4F7, Q96159 Clostridium kluyveri, Clostridium Q97E56 acetobutylicum 1870 TFGPTFRAENS Aeromonas hydrophila, Bacillus A0KIC3, Q6HCVV9, Q96159 thuringiensis, Bacillus cereus, Bacillus Q633N6, Q81L32, anthracis, Bacillus cereus, Bacillus Q72ZI3, A7GTK8, cytotoxicus, Bacillus cereus, Q817I8, Q24MK1, Desulfitobacterium hafniense, A6LIA1, Q5L8W2, Parabacteroides distasonis, A6L0U5, Q64P24, Bacteroides fragilis, Bacteroides Q8A0Z8, A0PY64, vulgatus, Bacteroides fragilis, A3DBI2, Q0TMF3, Bacteroides thetaiotaomicron, P58693, Q0SQ51, Clostridium novyi, Clostridium Q899M9, A5HZE1, thermocellum, Clostridium A7FRK8, B2UXS0, perfringens, Clostridium perfringens, A7GB01, B2TI01, Clostridium perfringens, Clostridium A6LPI6, Q317J6, tetani, Clostridium botulinum, Q72G53, AlV9B8, Clostridium botulinum, Clostridium Q1RDS7, P0A8M0, botulinum, Clostridium botulinum, B1IW01, P0A8M1, Clostridium botulinum, Clostridium Q0TJC3, A7ZYN3, beijerinckii, Desulfovibrio alaskensis, A7ZK21, P58694, Desulfovibrio vulgaris, Desulfovibrio Q74E08, Q39SY7, vulgaris, Escherichia coli, Escherichia A5G5R2, A5UF16, coli, Escherichia coli, Escherichia coli, A5UCB9, P43829, Escherichia coli, Escherichia coli, Q0I2M9, B8F3Y5, Escherichia coli, Escherichia coli, A6T726, Q7MVE5, Geobacter sulfurreducens, Geobacter B2RK42 metallireducens, Geobacter uraniireducens, Haemophilus influenzae, Haemophilus influenzae, Haemophilus influenzae, Haemophilus somnus, Haemophilus parasuis, Klebsiella pneumoniae, Porphyromonas gingivalis, Porphyromonas gingivalis 1871 TFNDDIQGT Bacillus subtilis P45868 P48163 1872 TFNMDEYVG Proteus mirabilis B4ESJ0 P46926 1873 TFNMDEYVGL Enterobacter sp., Haemophilus A4W844, Q7VKN1, P46926 ducreyi, Porphyromonas gingivalis, B2RJ01, Q7MW43 Porphyromonas gingivalis 1874 TFNMDEYVGLP Aeromonas hydrophila, Aeromonas A0KIG3, A4SPM2, P46926 salmonicida, Parabacteroides A6LHV2, Q64XP2, distasonis, Bacteroides fragilis, Q5LGU0, Q8A094, Bacteroides fragilis, Bacteroides A6L7Q8, A8AJE0, thetaiotaomicron, Bacteroides C6C0A2, Q8FJX7, vulgatus, Citrobacter koseri, B7LKT5, Q1REP9, Desulfovibrio salexigens, Escherichia B1LLC0, B6HYN6, coli, Escherichia fergusonii, B7N9S4, P0A759, Escherichia coli, Escherichia coli, B1IY50, Q0TK13, Escherichia coli, Escherichia coli, A7ZXT7, A1A8T7, Escherichia coli, Escherichia coli, B1X6L1, B7M5J6, Escherichia coli, Escherichia coli, C4ZWF4, B7NMM9, Escherichia coli, Escherichia coli, B7MPI3, P0A760, Escherichia coli, Escherichia coli, B5YQM0, B7UKV0, Escherichia coli, Escherichia coli, B7L9L4, B7MFT4, Escherichia coli, Escherichia coli, A7ZJ60, Q0I4B9, Escherichia coli, Escherichia coli, B8F877, B5XZG9, Escherichia coli, Escherichia coli, A6T6C1 Haemophilus somnus, Haemophilus parasuis, Klebsiella pneumoniae, Klebsiella pneumoniae 1875 TFVAELKGL Haemophilus somnus, Haemophilus Q0I491, P44427, P40926 influenzae, Haemophilus influenzae, A5UCQ1, A5UIX3, Haemophilus influenzae, Q4QL89 Haemophilus influenzae 1876 TGAAQGIGR Pseudomonas putida P23102 P15428 1877 TGAGISTASG Enterococcus faecalis Q839C6 Q8N6T7 1878 TGARGLRSI Lactobacillus reuteri, Lactobacillus A5VJ94, Q88VE2, O76031 plantarum, Lactobacillus salivarius, Q1WU81, Q03QN7, Lactobacillus brevis, Enterococcus Q833M7, Q03W09, faecalis, Leuconostoc mesenteroides, Q03F27 Pediococcus ntosaceus 1879 TGASSGIGE Listeria innocua Q92EK7 Q9Y394 1880 TGASSGIGEE Staphylococcus saprophyticus Q49WS9 Q9Y394 1881 TGEISPGMI Desulfovibrio alaskensis Q3QZW0 P60174 1882 TGGIASGKS Streptococcus pyogenes, P58102, Q48UU5, Q8WVC6 Streptococcus pyogenes, P0DA44, Q5XDE3, Streptococcus pyogenes, P0DA45, P63834, Streptococcus pyogenes, Q8DSZ0 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans 1883 TGHAEWRV Ralstonia solanacearum Q8Y1C6 Q9UJ68 1884 TGIKWDLL Clostridium phytofermentans, A9KK92, B8DRD2, P06576 Desulfovibrio vulgaris, Desulfovibrio Q72E04, A1VFJ5, vulgaris, Desulfovibrio vulgaris, Q313W0, B8J439 Desulfovibrio alaskensis, Desulfovibrio desulfuricans 1885 TGIKVVDLLAPY Arcobacter butzleri, Bacillus A8EV70, P41009, P06576 caldotenax, Bacillus halodurans, Q9K6H5, A7GV56, Bacillus cytotoxicus, Bacillus sp., P07677, P12698, Bacillus megaterium, Bacillus P22478, B9IRT7, pseudofirmus, Bacillus cereus, B7HY64, Q72XE8, Bacillus cereus, Bacillus cereus, A0RL95, Q6HAY0, Bacillus thuringiensis, Bacillus Q81JZ5, Q630U3, thuringiensis, Bacillus anthracis, C1F0M8, C3LFH9, Bacillus cereus, Bacillus cereus, C3P1F4, Q65DX4, Bacillus anthracis, Bacillus anthracis, B7JGN0, A9VSA3, Bacillus licheniformis, Bacillus cereus, Q5W378, Q814W2, Bacillus weihenstephanensis, Bacillus B7HFK1, B7IQV8, clausii, Bacillus cereus, Bacillus A8FIB2, P37809, cereus, Bacillus cereus, Bacillus Q180W5, A6LQH6 pumilus, Bacillus subtilis, ptoclostridium difficile, Clostridium beijerinckii 1886 TGIKVVDLLAPYA Campylobacter jejuni, Campylobacter Q0PC30, A1VXJ0, P06576 jejuni, Campylobacter jejuni, Q5HX59, A8FJR2, Campylobacter jejuni, Campylobacter A7ZC37, A7H1I1, concisus, Campylobacter jejuni, A7H017, B9KES3, Campylobacter curvus, A0RR26, A7I177, Campylobacter lari, Campylobacter B81579 fetus, Campylobacter hominis, Clostridium cellulolyticum 1887 TGLSGAGKTT Pseudomonas aeruginosa P29811 O43252 1888 TGPCGPCSEI Clostridium thermocellum A3DKB6 P49588 1889 TGPNMGGKS Neisseria gonorrhoeae, Neisseria Q5F5J4, A9M4L8, P20585 meningitidis, Neisseria meningitidis, A1KWM6, B4RPP9, Neisseria gonorrhoeae, Neisseria Q9JWT7, Q9JX94, meningitidis, Neisseria meningitidis, Q2KD76, Q1MMA5, Rhizobium etli, Rhizobium P56883, Q98C21 leguminosarum, Rhizobium meliloti, Rhizobium loti 1890 TGPNMGGKSTY Haemophilus ducreyi Q7VKA1 P43246 1891 TGPNMSGKSTY Streptococcus pneumoniae, C1CH06, C1CN23, O15457 Streptococcus pneumoniae, B8ZPK0, C1CAQ5, Streptococcus pneumoniae, Q04I96, P0A3R3, Streptococcus pneumoniae, P0A3R4, B1I9E5 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1892 TGQDGSYLAEFLL Escherichia coli, Escherichia coli, P0AC90, P0AC88, O60547 EKGYEVHGI Escherichia coli P0AC89 1893 TGRKIIVDTY Lactobacillus casei, Lactobacillus B3WCC9, Q03AU4, Q00266 casei, Clostridium botulinum, B2UZL0, B2TK10, Clostridium botulinum, Clostridium A0Q2Y4, B0S2I6, novyi, Finegoldia magna, Q03VI4, B1N092 Leuconostoc mesenteroides, Leuconostoc citreum 1894 TGRTHQIRVH Bacillus subtilis, Bacillus subtilis, Q45480, O31613, Q8IZ73 Escherichia coli, Escherichia coli, Q8X8J3, P0AA39, Escherichia coli, Escherichia coli, Q8FIP7, P65834, Escherichia coli, Escherichia coli, Q8X9F0, P33643, Haemophilus ducreyi, Haemophilus P59835, P44433, influenzae, Haemophilus influenzae, P44445, Q9L7A7, Haemophilus ducreyi, Neisseria Q9JVB6, Q9K0B0, meningitidis, Neisseria meningitidis, Q9HZM9, P33640, Pseudomonas aeruginosa, Q8XYX8 Pseudomonas aeruginosa, Ralstonia solanacearum 1895 TGRTHQIRVHL Bacillus subtilis, Helicobacter pylori, P54604, Q9ZKP5, Q8IZ73 Helicobacter pylori O25610 1896 TGSFKIRGA Escherichia coli, Escherichia coli, P0AGF7, P0AGF6, Q9GZT4 Escherichia coli P0AGF8 1897 TGSGKSSLL Haemophilus influenzae P45081 Q96J66 1898 TGSGKSTLL Bacillus licheniformis Q65P76 P13569 1899 TGTDEHGLK Rhizobium loti Q98MV8 Q96GW9 1900 TGTDEHGLKI Lactobacillus plantarum Q88Z97 Q96GW9 1901 TGTPWGGLT Proteus mirabilis, Proteus mirabilis B4F1A3, Q7X3P1 P05089 1902 THGSLEVGK Pseudomonas fluorescens, Q3KJE5, Q4KJN0 Q96NU7 Pseudomonas fluorescens 1903 THIRLNIFPDGGIA Acinetobacter baumannii B2I1L5 Q8N6M5 RLRV 1904 THLGLPVFNTV Escherichia coli, Escherichia coli, P0AGF0, P0AGE9, P53597 Escherichia coli, Haemophilus P0AGF1, P45102 influenzae 1905 THLGLPVFNTVKE Pseudomonas aeruginosa Q51567 P53597 A 1906 TIAFGIRNV Geobacter daltonii, Geobacter B9LZA9, A5GA37, Q5HYK3 uraniireducens, Geobacter Q74EU2 sulfurreducens 1907 TIGKGFQGV Rhizobium loti Q98N57 P09001 1908 TIIEPTSGNTGIGL Bacillus subtilis P37887 P35520 A 1909 TIMENIRFG Bacillus subtilis O31708 Q9NUT2 1910 TIMGHVDHGKT Campylobacter lari B9KEV0 P46199 1911 TITMVGDLK Parabacteroides distasonis A6LA97 P27708 1912 TKDGVTVAK Acinetobacter baylyi, Q6F8P6, B1ZAU5, P10809 Methylobacterium populi, B1LVA0, B8DJC4, Methylobacterium radiotolerans, A5G9I2, Q747C7, Desulfovibrio vulgaris, Geobacter B5E9Y2, C6DY43, uraniireducens, Geobacter B9LZ35, Q39ZP5, sulfurreducens, Geobacter A9M0Q6, A1KW52, bemidjiensis, Geobacter sp., P57006, P42385, Geobacter daltonii, Geobacter B4RRA1, Q5F541, metallireducens, Neisseria P29842, Q981J9, meningitidis, Neisseria meningitidis, Q98IH9, Q6W1D5, Neisseria meningitidis, Neisseria Q983S4, Q98AX9, meningitidis, Neisseria gonorrhoeae, Q6W163, Q92ZQ4, Neisseria gonorrhoeae, Neisseria Q98IV5, A5VBQ6 gonorrhoeae, Rhizobium loti, Rhizobium loti, Rhizobium sp., Rhizobium loti, Rhizobium loti, Rhizobium sp., Rhizobium meliloti, Rhizobium loti, Sphingomonas wittichii 1913 TKTRAEVRGGGR Corynebacterium efficiens Q8FS79 Q9BYD3 KP 1914 TLAIIKPDA Haemophilus parasuis B8F3E4 Q86XW9 1915 TLAIIKPDAV Haemophilus somnus Q0I2G6 Q86XW9 1916 TLGGTCLNVGC Pseudomonas putida P31046 P09622 1917 TLLFANAGM Campylobacter jejuni A1VYL8 P49588 1918 TLLGQNVNS Clostridium botulinum, Clostridium B1IM69, A7GE46, Q96SZ6 botulinum, Clostridium botulinum, BlKSA4, A5I2S3, Clostridium botulinum, Clostridium A7FUL1, Q895H1, botulinum, Clostridium tetani, Q8XLE9, Q0TRE5, Clostridium perfringens, Clostridium A000M5, Q0STS9, perfringens, Clostridium novyi, Q97I18, A3DDI9, Clostridium perfringens, Clostridium B2V276, B2TIA8, acetobutylicum, Clostridium B0S1C0, Q6A8Z7 thermocellum, Clostridium botulinum, Clostridium botulinum, Finegoldia magna, Propionibacterium acnes 1919 TLLGQNVNSF Desulfovibrio vulgaris, Desulfovibrio A1VF04, Q72DE5 Q96SZ6 vulgaris 1920 TLNFGPQHP Clostridium beijerinckii A6LXQ2 O75306 1921 TLNFGPQHPAAH Ralstonia pickettii B2U7Q8 O75306 GVLRLV 1922 TLVFDVELL Escherichia coli, Escherichia coli, P65765, P65764, P62942 Escherichia coli P45523 1923 TLVFEVELL Escherichia coli P0A9L3 P26885 1924 TLYHWDLPQ Bacillus circulans, Paenibacillus Q03506, P22505, Q9UEF7 polymyxa, Bacillus subtilis P42403 1925 TMLRVKDPK Pseudomonas aeruginosa Q9HU72 Q04760 1926 TMSTVGYGD Escherichia coli P31069 Q12791 1927 TMYGQMTAGS Bacillus clausii, Streptomyces Q5WCP7, Q9KZ75, Q96N76 coelicolor, Streptomyces avermitilis, Q82HL2, B1VUR5 Streptomyces griseus 1928 TNAGKSTLFN Haemophilus somnus Q0I442 Q8NC60 1929 TNASRTMLF Clostridium phytofermentans A9KQC2 Q14409 1930 TNASRTMLFNIH Citrobacter koseri, Enterobacter sp., A8AL00, A4WG72, Q14409 Escherichia coli, Escherichia coli, B7NU81, B1LNM9, Escherichia coli, Escherichia coli, B7NFM3, P0A6F3, Escherichia coli, Escherichia coli, B1IVF3, Q0TAD8, Escherichia coli, Escherichia coli, A8A731, B1X1392, Escherichia coli, Escherichia coli, C5A093, P0A6F4, Escherichia coli, Escherichia coli, B5YZ64, B7MI58, Escherichia coli, Escherichia coli, B7LA23, A7ZUE0, Escherichia fergusonii, Escherichia B7LUS9, B7M6X7, coli, Escherichia coli, Escherichia coli, B7UNP6, B7N2R7, Haemophilus influenzae, P44400, A5UE44, Haemophilus influenzae, A5UHH7, Q4QMM7, Haemophilus influenzae, A6TFR2, B5XTD4, Haemophilus influenzae, Klebsiella Q87XL0, Q4ZPI7, pneumoniae, Klebsiella pneumoniae, Q48F01 Pseudomonas syringae, Pseudomonas syringae, Pseudomonas savastanoi 1931 TNASRTMLFNIHS Escherichia coli Q8FBC3 Q14409 L 1932 TNGSQFFITT Streptomyces anulatus Q06118 P30414 1933 TNGSQFFLT Streptomyces anulatus P77949 Q9UNP9 1934 TNPVDILTY Bacillus methylotrophicus, Bacillus A7Z152, P13714, Q6ZMR3 subtilis, Bacillus P14561, P20619, psychrosaccharolyticus, Bacillus A8F9Q8, Q65NP0, psychrosaccharolyticus, Bacillus Q8FLV6 pumilus, Bacillus licheniformis, Corynebacterium efficiens 1935 TNVPGVFAAGD Bacillus sp. P26829 Q96NN9 1936 TPFYPRSPYG Pseudomonas aeruginosa Q51366 O60547 1937 TPGVAADLSHI Proteus mirabilis B4F2A1 P40926 1938 TPIINPPQSAILGM Escherichia coli, Escherichia coli, P0AFG6, P0AFG7, P36957 H Haemophilus influenzae P45302 1939 TPIPHNGCRP Acinetobacter baumannii, B2HZ85, B0V6U5, P82912 Acinetobacter baumannii, B0VQU1, B7IA16, Acinetobacter baumannii, A3M961, B7GW25, Acinetobacter baumannii, Q6F7T5, A4SSY3, Acinetobacter baumannii, A0KF43, A5N4S3, Acinetobacter baumannii, B9DYD5, A6LPT8, Acinetobacter baylyi, Aeromonas B1KSJ8, A7GJ47, salmonicida, Aeromonas hydrophila, C1FMS4, A3DJJ9, Clostridium kluyveri, Clostridium A4WFA5, B7LRR4, kluyveri, Clostridium beijerinckii, Q1R635, B1LHB1, Clostridium botulinum, Clostridium B6I211, B7NDR9, botulinum, Clostridium botulinum, P0A7R9, 611Q02, Clostridium thermocellum, P0A7S0, Q0TCG4, Enterobacter sp., Escherichia A1AGI8, B7LHZ9, fergusonii, Escherichia coli, A8A5A2, B1X6E9, Escherichia coli, Escherichia coli, C4ZUF2, B7UK21, Escherichia coli, Escherichia coli, B7M103, B7N182, Escherichia coli, Escherichia coli, B7NLL7, B5YT16, Escherichia coli, Escherichia coli, P0A7S1, B7MCR3, Escherichia coli, Escherichia coli, A7ZSI6, Q39XY1, Escherichia coli, Escherichia coli, Q7VKF6, B8F6P8, Escherichia coli, Escherichia coli, Q0I139, A5UDS4, Escherichia coli, Escherichia coli, Q4QM99, P44379, Escherichia coli, Escherichia coli, A6TEV0, B4F1K7, Escherichia coli, Escherichia coli, B7V666, Q02T57, Geobacter metallireducens, A6UZL1, Q9HWF8, Haemophilus ducreyi, Haemophilus A4XZ67, A4VHQ3, parasuis, Haemophilus somnus, P59374, B1JAI9, Haemophilus influenzae, A5VXS0, Q1IFU3, Haemophilus influenzae, B0KK89, Q889U8, Haemophilus influenzae, Klebsiella Q4ZMR6, Q3K610, pneumoniae, Proteus mirabilis, C3K2V3, Q48D59, Pseudomonas aeruginosa, Q4K555, B2FQK6, Pseudomonas aeruginosa, B4SLH3 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas stutzeri, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida, Pseudomonas syringae, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas fluorescens, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 1940 TPIPHNGCRPRK Methylobacterium sp., B0UHU6, B8IT34, P82912 Methylobacterium nodulans, C3MB02, Q925W7, Rhizobium sp., Rhizobium meliloti, Q98N34, Q2K9J3, Rhizobium loti, Rhizobium etli, B5ZZ56, Q1M1B8, Rhizobium leguminosarum, B3PWU4 Rhizobium leguminosarum, Rhizobium etli 1941 TPTPLGEGK Propionibacterium acnes Q6ABS5 P11586 1942 TPVFMPVGT Acinetobacter baumannii, A3M8S3, B0V625, Q9BXR0 Acinetobacter baumannii, B7I976, B7GWL4, Acinetobacter baumannii, B2HYN7, Q6FEJ4, Acinetobacter baumannii, O32053, A7Z766, Acinetobacter baumannii, Q65GP9, A8FFQ9, Acinetobacter baylyi, Bacillus subtilis, A7ZD89, A1VZZ8, Bacillus methylotrophicus, Bacillus Q5HUF2, A8FM59, licheniformis, Bacillus pumilus, Q9PNT0, A7H331, Campylobacter concisus, B8I6M0, Q9JVA4, Campylobacter jejuni, Campylobacter Q5F9U5, A1KSY1, jejuni, Campylobacter jejuni, B4RJY2, A9M374, Campylobacter jejuni, Campylobacter Q9K096 jejuni, Clostridium cellulolyticum, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis 1943 TPVFMPVGTQ Arcobacter butzleri, Desulfovibrio A8ERD1, C4XSI9, Q9BXR0 maeticus, Helicobacter pylori, Q9ZMF4, Q7VHX2 Helicobacter hepaticus 1944 TPVFMPVGTQAT Desulfitobacterium hafniense, B8FQV2, Q8RDN0 Q9BXR0 Fusobacterium nucleatum 1945 TPVPGGVGPMT Arcobacter butzleri, Bacillus A8ESH8, Q9K966, P13995 halodurans, Desulfovibrio maeticus, C4XLR8, C6BSL6, Desulfovibrio salexigens, B8DMA9, Q6W210 Desulfovibrio vulgaris, Rhizobium sp. 1946 TQGKGLMPD Haemophilus influenzae P44557 P11766 1947 TQGKGLMPDGT Escherichia coli, Escherichia coli, B1J085, A7ZX04, P11766 Escherichia coli, Escherichia coli, Q8X5J4, A7ZIA4, Escherichia coli, Escherichia coli, Q1RFI7, P25437, Escherichia coli, Escherichia coli, Q0TKS7, A1A835, Escherichia coli, Escherichia coli Q8FKG1, B1LIP1 1948 TQIPILTMP Enterococcus hirae, Enterococcus Q08637, Q834X8 P15313 faecalis 1949 TQKCIRAGGKHND Akkermansia muciniphila B2UKT4 P49588 L 1950 TQNVDALHT Pseudomonas syringae Q882K4 Q9Y6E7 1951 TRLTESGLS Rhizobium meliloti, Rhizobium sp., Q92QR8, C3MA28, Q7KZN9 Rhizobium loti, Sphingomonas Q982X5, A5VF68 wittichii 1952 TRVGGIPEV Bacillus anthracis Q81ST7 P37287 1953 TSGATESNN Pseudomonas syringae, Q4ZX34, Q48M05, Q9Y697 Pseudomonas savastanoi, Q887A1 Pseudomonas syringae 1954 TSGSTGKPK Bacillus subtilis O07619 Q9NR19 1955 TSGSTGKPKGV Bacillus licheniformis O68006 Q9NR19 1956 TSGSTGLPK Escherichia coli P37353 O95573 1957 TSGSTGRPKGVM Escherichia coli, Escherichia coli P11454, Q8XBV9 O60488 1958 TSGTTGFPK Bacillus subtilis O31826 P0C7M7 1959 TSGTTGLPK Staphylococcus haemolyticus, Q4L3Q0, Q9KWK5, Q9H6R3 Staphylococcus aureus, Q5HIA1, Q7A1Q0, Staphylococcus aureus, Q7A769, Q6GBR2, Staphylococcus aureus, Q99W34, Q6GJ94, Staphylococcus aureus, Q8CQ67, Q5HRH4 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 1960 TSGTTGLPKGV Streptococcus agalactiae, Q8VM67, P59591, Q9H6R3 Streptococcus agalactiae, Q3JZ94 Streptococcus agalactiae 1961 TSGTTGNPK Bacillus subtilis P96575 Q96GR2 1962 TSVLKRAIRTL Desulfovibrio alaskensis Q30WZ8 P15259 1963 TTRSPREGEV Bacillus subtilis O34328 Q96QZ7 1964 TTTTHKTLRG Lactobacillus salivarius, Eubacterium Q1WTR3, C4ZH69, P34897 rectale, Methylobacterium B1LZ88, C1C6Z9, radiotolerans, Streptococcus Q97R16, B1IB13, pneumoniae, Streptococcus C1CRE4, Q8DPZ0, pneumoniae, Streptococcus Q04KR0, C1CKA2, pneumoniae, Streptococcus A4VUM9, A4W0W9, pneumoniae, Streptococcus C1QE16, B2IPI0, pneumoniae, Streptococcus B8ZPH5, B5E4E3 pneumoniae, Streptococcus pneumoniae, Streptococcus suis, Streptococcus suis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 1965 TTVVADTGD Aeromonas salmonicida, Edwardsiella A45K74, C5B7L0, P37837 ictaluri, Escherichia coli, Escherichia Q8FLD1, KOBE10, coli, Escherichia coli, Escherichia coli, P0A870, P0A871, Proteus mirabilis, Rhizobium etli, B4F2V2, Q2K414, Rhizobium etli, Rhizobium B3Q0T5, B5ZQY2 leguminosarum 1966 TTVVADTGDF Pseudomonas fluorescens, Q4KF90, B7UWP0, P37837 Pseudomonas aeruginosa, Q9I047, Q02NV3, Pseudomonas aeruginosa, A6V3U3 Pseudomonas aeruginosa, Pseudomonas aeruginosa 1967 TVIGGGDTA Campylobacter lari B9KFD9 P07205 1968 TVLIMELINN Fusobacterium nucleatum Q8RGE2 P06576 1969 TVPAYFNDA Bacillus methylotrophicus, Bacillus A7Z6W1, P17820, P11021 subtilis, Clostridium perfringens, Q0SRE3, P26823, Clostridium perfringens, Clostridium Q0TNS7, O33528, perfringens, Rhizobium Q4L6T0, B9DNK0, leguminosarum, Staphylococcus A8Z4B9, P64408, haemolyticus, Staphylococcus Q5HFI0, Q6G8Y7, carnosus, Staphylococcus aureus, Q6GGC0, P99110, Staphylococcus aureus, P64407, A6QHC3, Staphylococcus aureus, Q2FXZ2, A5ITA8, Staphylococcus aureus, A6U252, Q2FGE3, Staphylococcus aureus, A7X2Y1, P45554, Staphylococcus aureus, Q2YT47 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1970 TVPAYFNDAQR Akkermansia muciniphila, Arcobacter B2UKV6, A8EWT6, P11021 butzleri, Campylobacter jejuni, O69298, Q5HV33, Campylobacter jejuni, Campylobacter A8FLH2, B9KCH0, jejuni, Campylobacter lari, A7H484 Campylobacter jejuni 1971 TVPAYFNDAQRQ Porphyromonas gingivalis, P0C937, B2RJ90 P11021 ATK Porphyromonas gingivalis 1972 TVPAYFNDAQRQ Acinetobacter baumannii, A3M8W9, B2HZZ7, P11021 ATKDAG Acinetobacter baumannii, B0V5U4, B7IBK5, Acinetobacter baumannii, B7H317, Q6F6N3, Acinetobacter baumannii, A0KMI6, A4SQ25, Acinetobacter baumannii, P71331, B2GBQ5, Acinetobacter baylyi, Aeromonas B0UR84, A8ALU3, hydrophila, Aeromonas salmonicida, A9KKU0, C4XQ63, Aggregatibacter B8DRD6, A1VFG6, actinomycetemcomitans, Q72DW8, B8J402, Lactobacillus fermentum, C5B7L7, A4W6D5, Methylobacterium sp., Citrobacter A7ZW7, Q1RG18, koseri, Clostridium phytofermentans, P0A6Y8, B1IRG0, Desulfovibrio maeticus, Desulfovibrio P0A6Y9, Q0TLX5, vulgaris, Desulfovibrio vulgaris, A1A766, P0A6Z0, Desulfovibrio vulgaris, Desulfovibrio A7ZHA4, Q0I3V2, desulfuricans, Edwardsiella ictaluri, P48209, A6T4F4, Enterobacter sp., Escherichia coli, B5Y242, B8IHL3, Escherichia coli, Escherichia coli, B7KSZ4, A9W6R7, Escherichia coli, Escherichia coli, B1ZGR1, B1LZ51, Escherichia coli, Escherichia coli, B4F2V5, P42374, Escherichia coli, Escherichia coli, B3PXH3, Q2KDW6, Haemophilus somnus, Haemophilus Q1MN11, B5ZWQ2, ducreyi, Klebsiella pneumoniae, A5V5P9 Klebsiella pneumoniae, Methylobacterium nodulans, Methylobacterium extorquens, Methylobacterium extorquens, Methylobacterium populi, Methylobacterium radiotolerans, Proteus mirabilis, Rhizobium meliloti, Rhizobium etli, Rhizobium etli, Rhizobium leguminosarum, Rhizobium leguminosarum, Sphingomonas wittichii 1973 TWRLNERHYG Lactobacillus johnsonii, Lactobacillus Q74LL9, Q88T35, P15259 plantarum, Lactobacillus acidophilus, Q5FMJ3, Q88YY8, Lactobacillus plantarum, Lactobacillus Q74L45, A9M1A2, johnsonii, Neisseria meningitidis, B4RIY7, Q5F7CQ3 Neisseria gonorrhoeae, Neisseria Q9JYF7, A1KV25, gonorrhoeae, Neisseria meningitidis, Q9JTF2 Neisseria meningitidis, Neisseria meningitidis 1974 TYGCQMNVN Fusobacterium nucleatum Q8RG43 Q96SZ6 1975 TYGGNPLGC Pseudomonas putida P59319 P04181 1976 TYGTGCFLL Clostridium tetani Q893Q3 Q14409 1977 TYNKDLQEDKE Streptococcus suis, Streptococcus A4VXZ3, A4W487 P04424 suis 1978 TYPLIGNYG Akkermansia muciniphila, B2URJ0, Q8KZA0, P27708 Desulfovibrio vulgaris, Desulfovibrio B8IZ56 desulfuricans 1979 TYPLIGNYGI Bacillus halodurans, Bacillus cereus, Q9K8V6, Q819S2, P27708 Bacillus thuringiensis, Bacillus Q6HES7, Q81WF1, anthracis, Bacillus cereus, Bacillus Q636D9, Q732I2, cereus, Bacillus caldolyticus, P52557, P77885, Lactobacillus plantarum, Bacillus P36838, O08317, subtilis, Lactobacillus plantarum, Q8XHB2, C6C0A9, Clostridium perfringens, Desulfovibrio Q5HPY9, Q49WY3, salexigens, Staphylococcus Q4L5Q4, Q8CPJ5, epidermidis, Staphylococcus P99147, P63730, saprophyticus, Staphylococcus Q5HGN0, P63729, haemolyticus, Staphylococcus Q6GA11, Q6GHN3, epidermidis, Staphylococcus aureus, P0DA13, P63735, Staphylococcus aureus, Q5XCR8, P0DA12, Staphylococcus aureus, P58894, P63731, Staphylococcus aureus, P63732 Staphylococcus aureus, Staphylococcus aureus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus agalactiae, Streptococcus agalactiae 1980 VAAGGRYDGL Geobacter metallireducens, Q39UD2, P60915 P12081 Geobacter sulfurreducens 1981 VAAGGRYDGLV Geobacter lovleyi B3EB83 P12081 1982 VAGETGSGK Escherichia coli P43329 Q7Z478 1983 VAGGMENMS Escherichia coli P76461 Q9BWD1 1984 VALLSGGGSGHE Escherichia coli P76015 Q3LXA3 P 1985 VAMVGDGIND Escherichia coli, Escherichia coli, Q8XD24, Q59385, Q04656 Haemophilus influenzae, Listeria P77868, Q60048 monocytogenes 1986 VAPGNAGTA Escherichia coli, Escherichia coli, P15640, Q8X612, P22102 Escherichia coli, Haemophilus Q8FB69, P43845, influenzae, Neisseria meningitidis, Q9JXA3, Q9JWU6 Neisseria meningitidis 1987 VASEIMAVL Bacillus licheniformis, Eubacterium Q65IA6, C4Z1V6 P11586 eligens 1988 VASYPFTTL Akkermansia muciniphila B2UQ30 Q9H4K7 1989 VATPVFMPVGTQ Helicobacter pylori, Helicobacter B2USB2, O08314, Q9BXR0 pylori, Helicobacter pylori, B5ZA47, Q1CUM2, Helicobacter pylori, Helicobacter B6JKL0 pylori 1990 VAVYNHYKRI Kocuria rhizophila B2GGB7 O76031 1991 VDAIVNAAN Lactobacillus plantarum, Citrobacter Q885K6, D2TT52, A1Z1Q3 rodentium, Pseudomonas aeruginosa, Q9HXU7, Q985D2, Rhizobium loti, Streptococcus Q8P0X2, P0DC29, pyogenes, Streptococcus pyogenes, P0DC28, Q5XC09, Streptococcus pyogenes, Q99ZI6 Streptococcus pyogenes, Streptococcus pyogenes 1992 VDDLLATGGT Desulfitobacterium hafniense, Q24UQ1, B8FQU0, P07741 Desulfitobacterium hafniense, A3DF48, A7GHS8, Clostridium thermocellum, Clostridium A7FY09, A5I6E1, botulinum, Clostridium botulinum, B1IME3, B1L0A2, Clostridium botulinum, Clostridium Q0TP22, Q8XJ22, botulinum, Clostridium botulinum, Q0SRP2, B2TMZ9, Clostridium perfringens, Clostridium B2V345, A5N1Z4, perfringens, Clostridium perfringens, B9E5P8, B8I3F7, Clostridium botulinum, Clostridium Q97GU0, C5BCZ7, botulinum, Clostridium kluyveri, B0S0M3, Q9ZLQ9, Clostridium kluyveri, Clostridium Q03W57, B1MZQ2, cellulolyticum, Clostridium B4EU76, C1CSJ8, acetobutylicum, Edwardsiella ictaluri, A4W292, A4VVY4, Finegoldia magna, Helicobacter A3CNR3, A8AWY0, pylori, Leuconostoc mesenteroides, P63544, P63545, Leuconostoc citreum, Proteus C1CLS6, B1ICZ7, mirabilis, Streptococcus pneumoniae, B8ZLT9, C1C8G8, Streptococcus suis, Streptococcus Q04JH1, B5E6M0, suis, Streptococcus sanguinis, B9DUP2, A2REX9, Streptococcus gordonii, P0CZ63, Q48TY5, Streptococcus pneumoniae, B5XL39, Q1J702, Streptococcus pneumoniae, P63546, Q1JM38, Streptococcus pneumoniae, P0CZ62, Q1JC56, Streptococcus pneumoniae, Q5XCH4, Q1JH84, Streptococcus pneumoniae, P63548, Q03K92, Streptococcus pneumoniae, Q5M3Y6, Q5LZD4, Streptococcus pneumoniae, Q8DT95 Streptococcus pneumoniae, Streptococcus uberis, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus thermophilus, Streptococcus mutans 1993 VDDLLATGGTM ptoclostridium difficile Q183I0 P07741 1994 VDDLLATGGTMN Clostridium novyi A0PZW4 P07741 1995 VDGKDVMPEVN Haemophilus somnus Q0I3C7 P06744 1996 VDILVNNAG Escherichia coli, Escherichia coli, P0AET8, P0AET9, Q6IAN0 Streptomyces violaceoruber P16542 1997 VDILVNNAGI Escherichia coli, Rhizobium meliloti, P76633, P06234, Q6IAN0 Rhizobium meliloti P50205 1998 VDKHSTGGVGD Aeromonas hydrophila, Aeromonas A0KPE3, A4SRU3, P19971 salmonicida, Bacillus subtilis, P39142, A4W699, Enterobacter sp., Escherichia coli, B7UR10, B1IS37, Escherichia coli, Escherichia coli, B6I6M9, B1LEI7, Escherichia coli, Escherichia coli, B7NH50, Q8FA52, Escherichia coli, Escherichia coli, B7LXU4, B7NW62, Escherichia coli, Escherichia coli, B5Z4R4, Q8X1335, Escherichia coli, Escherichia coli, A7ZVS5, A8A8B1, Escherichia coli, Escherichia coli, B7LEM8, P07650, Escherichia coli, Escherichia coli, B1XFJ2, B7MNI9, Escherichia coli, Escherichia B7LNS2, B7MTC8, fergusonii, Escherichia coli, Klebsiella A6THZ7, B5Y276, pneumoniae, Klebsiella pneumoniae, B4EWA3, C3MBH0, Proteus mirabilis, Rhizobium sp., Q92T50, Q5HM85, Rhizobium meliloti, Staphylococcus Q4L818, Q8CNH8, epidermidis, Staphylococcus Q5HE64, Q2FWC1, haemolyticus, Staphylococcus Q2FEZ3, Q6GET9, epidermidis, Staphylococcus aureus, Q6G7H4, Q8NVF6, Staphylococcus aureus, Q7A4D0, Q99SC3, Staphylococcus aureus, Q2YUL7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 1999 VDPLDGTKE Escherichia coli, Escherichia coli, Q8XCG6, Q8FAG5, Q95861 Escherichia coli P22255 2000 VDQETGEDL Methylobacterium extorquens, A9W8P8, B7KN55 Q14562 Methylobacterium extorquens 2001 VDQHAAHER Rhizobium etli, Rhizobium meliloti, Q2KBX7, Q92RP4, Q9UHC1 Rhizobium leguminosarum, B5ZSQ0, Q1MKU7, Rhizobium leguminosarum, B3PRD9, Q983L2, Rhizobium etli, Rhizobium loti, C3MGW0 Rhizobium sp. 2002 VDTWWQTETGGI Aeromonas hydrophila, Aeromonas A0KNI2, A4SJM6 Q9NUB1 salmonicida 2003 VDVLVNNAG Streptomyces coelicolor P16544 Q9NYR8 2004 VDVNVHPTK Lactobacillus salivarius, Lactobacillus Q1WT16, Q03R34, P40692 brevis, Lactobacillus plantarum, Q88UZ8, Q97I20, Clostridium acetobutylicum, Neisseria Q9JT52, A1KUP6, meningitidis, Neisseria meningitidis, A9M0G1, Q5F8M6, Neisseria meningitidis, Neisseria B4RLX4, Q9JYT2, gonorrhoeae, Neisseria gonorrhoeae, Q03EQ8 Neisseria meningitidis, Pediococcus ntosaceus 2005 VDVNVHPTKHEV Geobacter bemidjiensis, Geobacter B5EGD4, C6E4L2, P40692 sp., Geobacter sulfurreducens, Q74BP0, B3E5Z2, Geobacter lovleyi, Geobacter daltonii, B9M3N0, A5GEV5 Geobacter uraniireducens 2006 VEFSRNVLG Staphylococcus aureus, Q2FWD1, Q6GEU8, P17812 Staphylococcus aureus, Q2YUM6, A8YY92, Staphylococcus aureus, Q5HE73, Q6G7I3, Staphylococcus aureus, A6Q1X1, P65923, Staphylococcus aureus, A5IU52, P65924, Staphylococcus aureus, A6U3L2, P99072, Staphylococcus aureus, Q2FF01, A7X4X7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 2007 VEGDSAFGFSGM Oxalobacter formigenes P40149 Q9UJ83 E 2008 VEIAGPGFIN Geobacter sulfurreducens, Listeria Q74C63, A0ALP7, P54136 welshimeri, Listeria monocytogenes, B8DBE8, Q71WL8, Listeria monocytogenes, Listeria Q8Y493, Q927T2, monocytogenes, Listeria innocua, C1KYX7 Listeria monocytogenes 2009 VEIAGPGFINV Desulfovibrio alaskensis Q30Z04 P54136 2010 VELCGALKN Lactobacillus delbrueckii Q1G8H5 Q8N335 2011 VELNRKVLADLA Desulfovibrio vulgaris, Desulfovibrio Q728R8, A1VBB7 Q9BYC9 vulgaris 2012 VEPIQGEAG Staphylococcus aureus, P60299, Q6GAW9, P04181 Staphylococcus aureus, P60297, P60298, Staphylococcus aureus, Q5HHC8, Q6GID1, Staphylococcus aureus, Q8CT82, Q5HQK4, Staphylococcus aureus, B9DIU0 Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus carnosus 2013 VEVGPRDGLQNE Pseudomonas aeruginosa Q9I2A0 Q8TB92 K 2014 VEVNCETDFV Clostridium kluyveri, Clostridium A5N829, B9EI19, P43897 kluyveri, Clostridium tetani Q895L1 2015 VFDLGGGTFD Bacteroides vulgatus, Bacteroides A6L2X7, Q64X01, P11021 fragilis, Bacteroides fragilis, Q5LG30, A6LDG8, Parabacteroides distasonis, Q89YW6, Q93GF1 Bacteroides thetaiotaomicron, Prevotella loescheii 2016 VFTFGPTFRAE Lactobacillus plantarum, Bacillus Q88WA8, Q5WGB1, Q96I59 clausii, Enterococcus faecalis Q831X4 2017 VGAGSAGCVLA Pseudomonas putida, Pseudomonas Q9WWW2, Q00593 Q8NE62 oleovorans 2018 VGASGDLAPL Methylobacterium sp., Citrobacter B0UQ15, A8AJ15, P42357 koseri, Enterobacter sp., Klebsiella A4W8B5, B5XZ79, pneumoniae, Klebsiella pneumoniae, A6T6L1, B8II08, Methylobacterium nodulans, Q87UM1, Q3KJE6, Pseudomonas syringae, Q8VMR3, P21310, Pseudomonas fluorescens, Q88CZ7, Q02ER8, Pseudomonas fluorescens, Q9HU85, B7V3J1, Pseudomonas putida, Pseudomonas Q8XW29, O31197 putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Ralstonia solanacearum, Rhizobium meliloti 2019 VGASGDLAPLSH Rhizobium loti Q983I0 P42357 2020 VGDEGGFAPN Acinetobacter baylyi, Acinetobacter Q6FAT9, B0V677, P06733 baumannii, Acinetobacter baumannii, B212A5, B71918, Acinetobacter baumannii, A3M5Y1, B7H227, Acinetobacter baumannii, B0VQI4, Q97L52 Acinetobacter baumannii, Acinetobacter baumannii, Clostridium acetobutylicum 2021 VGDVRGKGL Bacillus subtilis P33189 Q9BYV1 2022 VGFPSVGKST Streptococcus thermophilus, Q03JJ8, Q5M3C8, Q9Y295 Streptococcus thermophilus, Q5LYR4 Streptococcus thermophilus 2023 VGFPSVGKSTLLS Bacillus halodurans, Bacillus Q9KDK0, Q65GM7, 09Y295 licheniformis, Bacillus pumilus, A8FFS8, Q5WHS8, Bacillus clausii, Lactobacillus sakei, Q38WI4, A7Z781, Bacillus methylotrophicus, Bacillus A9VIR5, B7IIV2, weihenstephanensis, Bacillus cereus, P20964, Q72ZY5, Bacillus subtilis, Bacillus cereus, Q6HD85, Q634A3, Bacillus thuringiensis, Bacillus cereus, C1ETN7, AQRJ47, Bacillus cereus, Bacillus thuringiensis, B7HQJ8, Q817U6, Bacillus cereus, Bacillus cereus, B9IZ16, B7JQ26, Bacillus cereus, Bacillus cereus, Q81LF0, B7HE73, Bacillus anthracis, Bacillus cereus, Q88VG4, A8YV14, Lactobacillus plantarum, Lactobacillus Q03QP2, Q043W1, helveticus, Lactobacillus brevis, Q5FKH5, Q74JN7, Lactobacillus gasseri, Lactobacillus Q1WT46, B3WE52, acidophilus, Lactobacillus johnsonii, Q039J3, Q834V4, Lactobacillus salivarius, Lactobacillus A0A1Y6, Q92BH7, casei, Lactobacillus casei, B8DHL1, Q71ZD3, Enterococcus faecalis, Listeria Q8Y6Z3, B9DNE7, welshimeri, Listeria innocua, Listeria Q8CNZ7, Q5HNQ7, monocytogenes, Listeria Q5HFB9, Q7A003, monocytogenes, Listeria A6QHI6, A8Z2H2, monocytogenes, Staphylococcus Q6G8S5, Q7A584, carnosus, Staphylococcus Q99TK9, A5ITG8, epidermidis, Staphylococcus Q2FXT1, Q2FG83, epidermidis, Staphylococcus aureus, A7X361, A6U2B2, Staphylococcus aureus, Q6GG60, Q2YT86, Staphylococcus aureus, Q49Y82, Q4L6Y9, Staphylococcus aureus, A4VUC8, A4W0M2, Staphylococcus aureus, Q8DYL0, Q8E465, Staphylococcus aureus, Q3K046, P0DB53, Staphylococcus aureus, P0DB52, Q1JLA1, Staphylococcus aureus, Q1JBB7, Q99Z94, Staphylococcus aureus, Q48SX8, Q8P0I6, Staphylococcus aureus, Q5XBM1, B5XLZ0, Staphylococcus aureus, Q1JGD5, Q1J652, Staphylococcus aureus, A2RE30, Q8DPV8, Staphylococcus aureus, Q04KK7, Q97QW8, Staphylococcus aureus, B5E4J4, B2IQ29, Staphylococcus saprophyticus, B1IBL9, B9DSH7, Staphylococcus haemolyticus, B8ZPS8, B4U3Q7, Streptococcus suis, Streptococcus A3CM33, C0MDB4, suis, Streptococcus agalactiae, C0MBS1, A8AWM9, Streptococcus agalactiae, Q8DUU2 Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus uberis, Streptococcus pneumoniae, Streptococcus equi, Streptococcus sanguinis, Streptococcus equi, Streptococcus equi, Streptococcus gordonii, Streptococcus mutans 2024 VGGIRASLYNA Stenotrophomonas maltophilia, B45P45, B2FKF0 Q9Y617 Stenotrophomonas maltophilia 2025 VGGRYSLWS Sphingomonas wittichii A5V9W3 P06744 2026 VGICGSDVH Escherichia coli P77280 Q00796 2027 VGICGSDVHY Morganella morganii Q59545 Q00796 2028 VGINGFGRIGR Bacillus subtilis, Bacillus coagulans, P09124, P15115, O14556 Bacteroides fragilis, Corynebacterium Q59199, Q01651, glutamicum, Escherichia fergusonii, B7LQ20, P0A9B3, Escherichia coli, Escherichia coli, P0A9B2, P0A9B4, Escherichia coli, Streptomyces Q829W3, Q9Z518, avermitilis, Streptomyces coelicolor, Q82IZ2 Streptomyces avermitilis 2029 VGINGFGRIGRL Streptococcus pyogenes, P0COG6, Q5XDW3, O14556 Streptococcus pyogenes, P68777, P0COG7, Streptococcus pyogenes, P0DB19, P0DB18, Streptococcus pyogenes, Q59906 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus dysgalactiae 2030 VGINGFGRIGRLV Escherichia coli P33898 O14556 L 2031 VGINGFGRIGRLV Escherichia coli P58072 O14556 LR 2032 VGKGITFDSGG Citrobacter koseri, Escherichia A8AD60, B7LKB6, P28838 fergusonii, Escherichia coli, B5Z0Z6, P58473, Escherichia coli, Escherichia coli, B1IWD8, A8A329, Escherichia coli, Escherichia coli, P37095, B1XAZ8, Escherichia coli, Escherichia coli, C4ZX98, Q8FF47, Escherichia coli, Escherichia coli, Q0TEW2, B7MYF7, Escherichia coli, Escherichia coli, B7UGW9, Q1R8K9, Escherichia coli, Escherichia coli, A1AE61, B7MI07, Escherichia coli, Escherichia coli, A7ZPW6, B6I595, Escherichia coli, Escherichia coli, B7M7M6, B7LDB5, Escherichia coli, Escherichia coli, B1LNH8, B7N6B0, Escherichia coli, Escherichia coli, B7NRH2, Q4QM33, Haemophilus influenzae, P58474, A6TCE4, Haemophilus influenzae, Klebsiella B5XNK4, Q6A9W5 pneumoniae, Klebsiella pneumoniae, Propionibacterium acnes 2033 VGKGITFDSGGIS Geobacter sulfurreducens Q74GB4 P28838 2034 VGKGITFDSGGISI Geobacter sp. C6E543 P28838 K 2035 VGKSSFINKV Fusobacterium nucleatum Q8RHS8 Q9BZE4 2036 VGLGNIWRFPY Haemophilus influenzae P44849 Q9H1V8 2037 VGLPAKSGV Citrobacter koseri, Enterobacter sp., A8AGR2, A4WAF3, O94925 Escherichia coli, Escherichia coli, P0A6W0, P0A6W1, Escherichia coli, Klebsiella P0A6W2, A6T8Z6, pneumoniae, Klebsiella pneumoniae, B5XQU9, Q8XQS6 Ralstonia solanacearum 2038 VGLTGGIASGK Haemophilus ducreyi Q7VM70 Q8WVC6 2039 VGLTGGIASGKS Propionibacterium acnes Q6A9M5 Q8WVC6 2040 VGRLKTGTP Arcobacter butzleri, Geobacter A8EWV0, Q74604, 09Y2Z2 sulfurreducens, Geobacter A5G9V2, Q39PR0 uraniireducens, Geobacter metallireducens 2041 VGRLKTGTPPRI Acinetobacter baumannii, B0V7I0, B7IC15, Q9Y2Z2 Acinetobacter baumannii, B7H0I9, A3M6R5, Acinetobacter baumannii, B2HUB2, B0VLL2, Acinetobacter baumannii, Q6F9Q1, B7UMK6, Acinetobacter baumannii, B6I3X8, B7NF57, Acinetobacter baumannii, P0A6U3, B1IWZ7, Acinetobacter baylyi, Escherichia coli, P0A6U4, B7NR43, Escherichia coli, Escherichia coli, Q0TAW8, A8A6K4, Escherichia coli, Escherichia coli, B1X9W9, B7N2I0, Escherichia coli, Escherichia coli, C4ZZ19, B7M597, Escherichia coli, Escherichia coli, B7L889, A7ZTV2, Escherichia coli, Escherichia coli, Q1R4J1, A1AHS1, Escherichia coli, Escherichia coli, B7MGG1, B5YXE5, Escherichia coli, Escherichia coli, Q8XAY0, B1LL68, Escherichia coli, Escherichia coli, B4F0D8, Q88RW8, Escherichia coli, Escherichia coli, Q87TS3, Q9F5X1, Escherichia coli, Escherichia coli, P25756, Q48BF4, Proteus mirabilis, Pseudomonas A5WBB4, A4VS73, putida, Pseudomonas syringae, B0KRB9, B1JFV2, Pseudomonas syringae, Q4K399, A6VF43, Pseudomonas putida, Pseudomonas Q9HT09, B7V7A2, savastanoi, Pseudomonas putida, Q02DE3, A4Y198, Pseudomonas stutzeri, Pseudomonas Q3K430, Q1I2H6 putida, Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas mendocina, Pseudomonas fluorescens, Pseudomonas entomophila 2042 VGRNIIHGSDS Staphylococcus aureus, A7X2H3, P99068, O60361 Staphylococcus aureus, A60H18, Q2FGX3, Staphylococcus aureus, A5ISZ7, Q2FYG7, Staphylococcus aureus, A6U1T7, Q5HFV4, Staphylococcus aureus, Q6GGU2, P68870, Staphylococcus aureus, Q2YY87, P68869, Staphylococcus aureus, A8Z448, Q6G994, Staphylococcus aureus, Q8NWN1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 2043 VGTDSHTTM Corynebacterium jeikeium Q4JVM4 P21399 2044 VGTGGTITG Neisseria meningitidis Q7DDL5 P35520 2045 VGTSSLRRA Fusobacterium nucleatum Q8RFP5 P08397 2046 VGTSSLRRAAQL Listeria welshimeri A0AJO5 P08397 2047 VHAENGELV Pseudomonas aeruginosa, Q9I676, Q59699 Q9BPU6 Pseudomonas putida 2048 VHRDIKPGN Corynebacterium glutamicum, Q8NU97, Q8FUI4, Q14164 Corynebacterium efficiens, Q9S2C0 Streptomyces coelicolor 2049 VHRDLKPAN Streptomyces coelicolor P54739 Q8IZL9 2050 VHRDLKPQNIL Streptococcus pneumoniae, Q8DNS0, Q04J43, 000534 Streptococcus pneumoniae, Q97PA9, Q8KY50 Streptococcus pneumoniae, Streptococcus pneumoniae 2051 VHRDLKPSN Streptomyces coelicolor, P54741, P54742 Q15418 Streptomyces griseus 2052 VHSLKDLPT Streptomyces coelicolor, Q9WX16, Q82E76 P08397 Streptomyces avermitilis 2053 VHSLKDLPTVLPP Desulfitobacterium hafniense, Q24VC8, B8G2M2 P08397 G Desulfitobacterium hafniense 2054 VIAHRLSTI Bacillus subtilis, Escherichia coli, Q07549, P0AAG5, Q9NRK6 Escherichia coli, Escherichia coli P0AAG6, P0AAG7 2055 VIAHRLSTV Bacillus subtilis O06967 Q9NUT2 2056 VIGAWDVQF Rhizobium loti Q98EV8 P06576 2057 VIGKGGETI Enterococcus faecalis, Streptococcus Q82ZJ2, Q8DW32, Q96AE4 mutans, Streptococcus equi, C0M913, C0MFB1, Streptococcus equi, Streptococcus B4U573, Q5M6F9, equi, Streptococcus thermophilus, Q5M1W9, B9DTE3, Streptococcus thermophilus, Q03MV9, A8AV53, Streptococcus uberis, Streptococcus A3CQG6, C1C076, thermophilus, Streptococcus gordonii, B8ZMC0, C1C5V9, Streptococcus sanguinis, Q8DQT0, Q04LT4, Streptococcus pneumoniae, B2IMQ9, B5E2A0, Streptococcus pneumoniae, C1CCVV4, B1IAA9, Streptococcus pneumoniae, Q97S28, A4VXQ4, Streptococcus pneumoniae, A4W401, Q8E1Z8, Streptococcus pneumoniae, Q3K3G9, Q8E7F6, Streptococcus pneumoniae, Q1J9S6, Q5X9W0, Streptococcus pneumoniae, Q1JJX5, Q48RA2, Streptococcus pneumoniae, Q1JEW6, P0DD13, Streptococcus pneumoniae, P0DD12, A2RGH2, Streptococcus pneumoniae, Q1J4N2, B5XIK4, Streptococcus suis, Streptococcus Q8NZC6, Q99XZ5 suis, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes 2058 VIHFAGLKAVGES Bifidobacterium longum, Neisseria E8MF10, P56985, Q14376 V meningitidis, Neisseria meningitidis, P56997, Q05026, Neisseria gonorrhoeae, Neisseria P56986 meningitidis 2059 VIHFAGLKAVGES Escherichia coli P09147 Q14376 VQKPL 2060 VILDEPTAG Staphylococcus saprophyticus Q49ZD9 O95477 2061 VILGQDPYH Campylobacter jejuni A7H1G3 P13051 2062 VILGQDPYHG Neisseria meningitidis, Neisseria A1KU26, Q9JZA1, P13051 meningitidis, Neisseria meningitidis, A9LZA2, Q9JUC4 Neisseria meningitidis 2063 VILGQDPYHGP Bacillus methylotrophicus A7ZA24 P13051 2064 VILTTGTFL Campylobacter jejuni, Campylobacter A8FMP4, Q5HTS6, Q9Y2Z2 jejuni, Campylobacter jejuni, A1W0H2, Q9PNA7, Campylobacter jejuni, Campylobacter A7H2I7 jejuni 2065 VILVGENPAS Streptococcus suis, Streptococcus A4VTM4, A4VZV9 P13995 suis 2066 VIWGNPANTN Corynebacterium jeikeium Q4JWV0 P40925 2067 VKAQKVRRLI Acinetobacter baylyi, Acinetobacter Q6FDY3, B0VS13, Q9H0R6 baumannii, Acinetobacter baumannii, A3M8F1, B0VEN3, Acinetobacter baumannii, B7GXC5, B2HY00, Acinetobacter baumannii, B7I7N2 Acinetobacter baumannii, Acinetobacter baumannii 2068 VKELVENSLDA Lactobacillus reuteri, Lactobacillus B2G6E6, A5VIX0 Q13670 reuteri 2069 VKELVENSLDAGA Akkermansia muciniphila, Clostridium B2ULE2, Q0STR3, Q13670 perfringens, Clostridium perfringens, Q0TRD5, Q8XL86 Clostridium perfringens 2070 VKLSDYKGKY Bacillus subtilis Q796Y8 P32119 2071 VKMVHNGIEY Staphylococcus aureus, Q931R3, P63335, P52209 Staphylococcus aureus, Q6GGI7, Q6G954, Staphylococcus aureus, P63334, Q5HFR2, Staphylococcus aureus, Q8CP47, Q5HP42 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus epidermidis 2072 VKMVHNGIEYGD Bacillus subtilis P80859 P52209 MQLI 2073 VKRTGAIVDVPVG Methylobacterium sp., B0UE41, B1LVH1, P25705 Methylobacterium radiotolerans, B1ZEE9, B8IN03, Methylobacterium populi, C3M9S3, Q92LK6, Methylobacterium nodulans, Q1MAZ0, B5ZSN9, Rhizobium sp., Rhizobium meliloti, Q2K3G8, Q98EV6, Rhizobium leguminosarum, B3PQ70 Rhizobium leguminosarum, Rhizobium etli, Rhizobium loti, Rhizobium etli 2074 VKSTLGPKG Lactobacillus plantarum Q88YM5 P78371 2075 VKVVILGQDPY Bacteroides fragilis, Bacteroides Q64QI5, Q5LA67 P13051 fragilis 2076 VKVVILGQDPYH Lactobacillus brevis, Campylobacter Q035K6, A7I0A8, P13051 hominis, Campylobacter fetus, A0RM89, B2RHL6, Porphyromonas gingivalis, Q7MXF6 Porphyromonas gingivalis 2077 VKVBVILGQDPYHG Neisseria gonorrhoeae, Neisseria B4RLL6, Q5F8I7, P13051 gonorrhoeae, Pediococcus ntosaceus Q03GV8 2078 VKVVILGQDPYHG Bacillus licheniformis, Bacillus Q65DN9, A8FIM7, P13051 P pumilus, Lactobacillus sakei, Q38VY5, B2GAM7, Lactobacillus fermentum, Citrobacter A8AD07, A6M317, koseri, Clostridium beijerinckii, A4WDE9, Q92EQ0, Enterobacter sp., Listeria innocua, Q8Y9X7, Q723S4, Listeria monocytogenes, Listeria Q3KGL4, Q1BT6, monocytogenes, Pseudomonas Q4KGS0, A5W8H2, fluorescens, Pseudomonas C3KDS6, Q88N05, entomophila, Pseudomonas B0KV50, B1J4J3, fluorescens, Pseudomonas putida, B1IBW9, A4W30, Pseudomonas fluorescens, A4W1D5, C1CRP5, Pseudomonas putida, Pseudomonas C1QED4, P23379, putida, Pseudomonas putida, B8Z048, Q8DPQ4, Streptococcus pneumoniae, B5E4R3, Q04KE2, Streptococcus suis, Streptococcus C1CKR8 suis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 2079 VKVVILGQDPYHG Acinetobacter baumannii, B0VMZ7, A3M500, P13051 PNQA Acinetobacter baumannii, B2HZE0, B0VD25, Acinetobacter baumannii, B7I526, B7H3L4, Acinetobacter baumannii, Q6F9Y2, A7GVX1 Acinetobacter baumannii, Acinetobacter baumannii, Acinetobacter baylyi, Campylobacter curvus 2080 VKVVILGQDPYHG Lactobacillus reuteri, Lactobacillus A5VIJ2, B2G626 P13051 PNQAHG reuteri 2081 VKVVILGQDPYHG Bacillus clausii, Enterococcus Q5WAZ9, Q836Z5, P13051 PNQAHGL faecalis, Haemophilus ducreyi, Q7VMC0, Q49VD1 Staphylococcus saprophyticus 2082 VKVVILGQDPYHG Aeromonas hydrophila, Aeromonas A0KMZ1, A4SK71 P13051 PNQAHGLCFSV salmonicida 2083 VKVVILGQDPYHG Pseudomonas syringae, Q4ZPC2, Q48ET5, P13051 PNQAHGLCFSVQ Pseudomonas savastanoi, Q87XE2 Pseudomonas syringae 2084 VKYSPDCIIIV Bacillus licheniformis Q65G89 P07195 2085 VLASASPRR Desulfitobacterium hafniense, Q24SM2, Q97JN3, O95671 Clostridium acetobutylicum, Q74A46, Q39X87, Geobacter sulfurreducens, Geobacter B5EHR3, C6E559 metallireducens, Geobacter bemidjiensis, Geobacter sp. 2086 VLATNIAET Escherichia coli P37024 Q7Z478 2087 VLAYEPVWAIGTG Bacteroides fragilis, Bacteroides Q64P83, Q5L923 P60174 KTA fragilis 2088 VLAYSGGLDT Corynebacterium glutamicum, O85176, A4QDZ4 P00966 Corynebacterium glutamicum 2089 VLAYSGGLDTS Aeromonas salmonicida, Aeromonas A4SIM5, A0KFV3, P00966 hydrophila, Lactobacillus reuteri, B2G6Y6, A5VJH1, Lactobacillus reuteri, Lactobacillus Q033U7, A1A1W7, casei, Bifidobacterium adolescentis, Q8G5F2, B3DSY7, Bifidobacterium longum, B7GTP0, C5BC58, Bifidobacterium longum, P61523, Q39Z72, Bifidobacterium longum, Edwardsiella B9M374, C6E6Y6, ictaluri, Geobacter sulfurreducens, A5GDA4, B5ED13, Geobacter metallireducens, Q03W70, B1MZP4, Geobacter daltonii, Geobacter sp., C1KX43, B8DH28, Geobacter uraniireducens, Geobacter Q71XS4, A0AKJ7, bemidjiensis, Leuconostoc Q929S9, Q8Y5H2, mesenteroides, Leuconostoc citreum, B9DIU4, Q49WA0, Listeria monocytogenes, Listeria Q8CPU3, Q5HQK0, monocytogenes, Listeria Q4L4X7, Q6GIC7, monocytogenes, Listeria welshimeri, A8Z067, P63644, Listeria innocua, Listeria P63645, A6QFH2, monocytogenes, Staphylococcus A5IRD9, Q5HHC4, carnosus, Staphylococcus Q2FZU1, Q2FIB4, saprophyticus, Staphylococcus A7X0H5, A6U068, epidermidis, Staphylococcus Q2YWS4, Q8NXF2, epidermidis, Staphylococcus Q6GAW5, B9DW9 haemolyticus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Streptococcus uberis 2090 VLDGGMGTMIQ Escherichia coli P13009 Q99707 2091 VLDVGCGSG Haemophilus somnus Q0I1M1 Q86X55 2092 VLDVGCGSGILS Eubacterium rectale, Eubacterium C4ZAZ2, C4Z0Q0 Q86X55 eligens 2093 VLEARDRVGGRT Kocuria rosea P40974 P21397 2094 VLFIADEIQ Staphylococcus saprophyticus Q49W96 P04181 2095 VLFIADEIQTGL Bacillus subtilis P38021 P04181 2096 VLGAQWGDEGKG Clostridium botulinum, Clostridium B2V1S6, B2TRE4, Q8N142 K botulinum, Clostridium botulinum, C1FNL8, A7GJL2, Clostridium botulinum, Clostridium B1IHP2, A5I7Y9, botulinum, Clostridium botulinum, A7FZF9, C3KWG8, Clostridium botulinum, Clostridium B1KU85, Q97D87, botulinum, Clostridium botulinum, A6M3K0 Clostridium acetobutylicum, Clostridium beijerinckii 2097 VLGEHGDSS Lactobacillus plantarum P59390 P00338 2098 VLGFPCNQF Escherichia coli P06610 P18283 2099 VLGIETSCD Aeromonas hydrophila, Aeromonas A0KGI3, A4SRB1, Q9H4B0 salmonicida, Bacillus subtilis, Bacillus O05518, Q65N07, licheniformis, Citrobacter koseri, A8APV4, A4WEJ9, Enterobacter sp., Escherichia coli, Q1R6R7, A1AFY6, Escherichia coli, Escherichia coli, Q0TD42, Q8FDG6, Escherichia coli, Escherichia coli, B7N068, B7MB00, Escherichia coli, Escherichia coli, Q8XBK3, B7UIX2, Escherichia coli, Escherichia B7LQD8, B6I436, fergusonii, Escherichia coli, B1IRQ2, A8A4M1, Escherichia coli, Escherichia coli, B7LZL4, B7NJS7, Escherichia coli, Escherichia coli, B7LGZ9, B5YRA4, Escherichia coli, Escherichia coli, A7ZRU6, P05852, Escherichia coli, Escherichia coli, B1LF56, B7ND53, Escherichia coli, Escherichia coli, C4ZQY1, B1XG69, Escherichia coli, Escherichia coli, A6TE46, B5XU22, Klebsiella pneumoniae, Klebsiella B4EW57, Q98Ei6 pneumoniae, Proteus mirabilis, Rhizobium loti 2100 VLIIGSGGREH Pseudomonas aeruginosa, Q9HUV8, Q87VR8, P22102 Pseudomonas syringae, Q88DK2 Pseudomonas putida 2101 VLILDEATS Streptococcus pneumoniae, P59653, Q03727 Q9NUT2 Streptococcus pneumoniae 2102 VLITGCSSGIGL Escherichia coli, Escherichia coli P0AFP5, P0AFP4 P14061 2103 VLIVEDIID Escherichia coli, Escherichia coli P0A9M3, P0A9M2 P00492 2104 VLIVEDIIDTG Haemophilus influenzae P45078 P00492 2105 VLLGPPGAGKGT Clostridium perfringens, Clostridium Q8XHU4, Q0SQG5, P54819 QA perfringens, Clostridium perfringens, Q0TMR7, A6LPT2, Clostridium beijerinckii, Clostridium B2TIJ6, B2UYD1, botulinum, Clostridium botulinum, B1VEX6 Corynebacterium urealyticum 2106 VLNGNEIGGGSIRI Stenotrophomonas maltophilia, B2FRP1, B45T40 Q6PI48 H Stenotrophomonas maltophilia 2107 VLPIIVFFS Haemophilus influenzae P44742 O00377 2108 VLRSSIREFL Pseudomonas putida, Pseudomonas B0KN22, B1J2K5, Q9BVL4 putida, Pseudomonas putida, A5WAA1, Q88CVV2, Pseudomonas putida, Pseudomonas A4XPR2, Q11G73, mendocina, Pseudomonas Q87VB1, Q4KJF3, entomophila, Pseudomonas syringae, Q9HUE6, B7V3B6, Pseudomonas fluorescens, A4VRA3, A6VDE4, Pseudomonas aeruginosa, Q4ZZ58, C3KBV5, Pseudomonas aeruginosa, Q48P81, Q02EZ4, Pseudomonas stutzeri, Pseudomonas Q3KJ68 aeruginosa, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas aeruginosa, Pseudomonas fluorescens 2109 VLRSSIREFLCSEA Ralstonia solanacearum Q8XYL0 Q9BVL4 M 2110 VLSGGEKQRI Plesiomonas shigelloides Q93SS1 P33897 2111 VLSGPSGAGK Desulfitobacterium hafniense Q24TX4 Q16774 2112 VLTSVDRDD Pseudomonas mendocina A4XYX3 O43766 2113 VLTVRAHQANSH Eubacterium rectale, Clostridium C4Z8Z2, A9KP29 P13051 phytofermentans 2114 VLVEVNCETDFV Geobacter uraniireducens, Geobacter A5G7W7, B9M5C5, P43897 daltonii, Geobacter sulfurreducens, P61333, Q39W87, Geobacter metallireducens, C6E513, B5EHW0 Geobacter sp., Geobacter bemidjiensis 2115 VLVKIAPDL Corynebacterium diphtheriae Q6NH79 Q02127 2116 VMEGFLRLR Pseudomonas aeruginosa Q9RPF2 P49279 2117 VMENGKVIE Staphylococcus saprophyticus, Q49W48, Q5HQQ9, Q96J65 Staphylococcus epidermidis, Q8CTB2 Staphylococcus epidermidis 2118 VMITGDNPLTA Streptomyces coelicolor Q9X8Z9 Q9HD20 2119 VMQEEIFGP Staphylococcus haemolyticus Q4L966 P51648 2120 VNAANSSLLGGG Streptomyces nogalater Q9EYI6 Q9BQ69 GVDG 2121 VNCNPETVSTD Bifidobacterium longum, Q8G815, B3Dq32, P31327 Bifidobacterium longum, B7GPW2, A1A0T4, Bifidobacterium longum, B8DTW3, P58939, Bifidobacterium adolescentis, Q8FT42, B2GI87, Bifidobacterium animalis, C5CCF1, Q9KXR6, Corynebacterium glutamicum, B1W463, Q827Q7 Corynebacterium efficiens, Kocuria rhizophila, Micrococcus luteus, Streptomyces coelicolor, Streptomyces griseus, Streptomyces avermitilis 2122 VNDAFGTAHR Lactobacillus reuteri, Lactobacillus B2G616, Q03SL7, P07205 brevis, Lactobacillus acidophilus, Q5FL50, A8YUE3, Lactobacillus helveticus, Lactobacillus P62413, B3WCVV5, johnsonii, Lactobacillus casei, Q03AK6, Q1WTB5, Lactobacillus casei, Lactobacillus Q042F2, Q8GIZ5, salivarius, Lactobacillus gasseri, Q1GB26, O32756, Lactobacillus delbrueckii, Q04BH1, Q2YSF1, Lactobacillus delbrueckii, A8Z1A1, Q2G031, Lactobacillus delbrueckii, P68820, Q2FIM0, Lactobacillus delbrueckii, P68821, A6QF82, Staphylococcus aureus, Q6GB57, A7WZS6, Staphylococcus aureus, P68819, A6TZQ2, Staphylococcus aureus, Q6GIL7, P99135, Staphylococcus aureus, Q5HHP4, A5IQX7, Staphylococcus aureus, B9DJJ6, Q5HQV3, Staphylococcus aureus, Q8CTD6, Q4L4K4, Staphylococcus aureus, Q49W00, A4VSN8, Staphylococcus aureus, A4VYY1, B4U0W3 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus carnosus, Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus saprophyticus, Streptococcus suis, Streptococcus suis, Streptococcus equi 2123 VNDAFGTAHRA Neisseria meningitidis, Neisseria A1KWN6, A9LZI3, P07205 meningitidis, Neisseria meningitidis, Q9JW58, Q9K1R0, Neisseria meningitidis, Neisseria B4RPR1, Q5F5K5 gonorrhoeae, Neisseria gonorrhoeae 2124 VNDAFGTAHRAH Akkermansia muciniphila, B2UKW8, Q38Y20, P07205 Lactobacillus sakei, Clostridium novyi, A0PYP1, Q898R3, Clostridium tetani, Clostridium B9E6B4, A5N2N8, kluyveri, Clostridium kluyveri, Q8XKU0, Q0TQY7, Clostridium perfringens, Clostridium Q0STD5, B2UY23, perfringens, Clostridium perfringens, C1FQW3, A5HYC0, Clostridium botulinum, Clostridium A7FQN7, A7G9Y0, botulinum, Clostridium botulinum, C3KYR4, B1IDB6, Clostridium botulinum, Clostridium B2TPX4, B1KTJ5, botulinum, Clostridium botulinum, Q181T8, A6LR05, Clostridium botulinum, Clostridium Q833I9, Q03GW7, botulinum, Clostridium botulinum, B5XIF1, A3CKQ4, ptoclostridium difficile, Clostridium Q8NZG3, Q1J9Y4, beijerinckii, Enterococcus faecalis, Q1JK32, Q5XA18, Pediococcus ntosaceus, P68897, Q8DXT0, Streptococcus pyogenes, Q3JZB8, Q8E3F0, Streptococcus sanguinis, A2RCM1, Q8VVB6, Streptococcus pyogenes, Q03IS8, P0DD05, Streptococcus pyogenes, Q48RF9, P0DD04, Streptococcus pyogenes, Q1J4X9, Q8DW2, Streptococcus pyogenes, Q5LY23, A8AUR9, Streptococcus pyogenes, B9DVS0, C1C5M3, Streptococcus agalactiae, Q8D0X8, B2IMA2, Streptococcus agalactiae, C1CCP3, C1CIZ1, Streptococcus agalactiae, C1CQ04, Q04LZ5, Streptococcus pyogenes, B8ZLX5, B1IA36, Streptococcus thermophilus, Q97S89, C0M940, Streptococcus thermophilus, C0MF22, B5E1U9 Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus mutans, Streptococcus thermophilus, Streptococcus gordonii, Streptococcus uberis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus equi, Streptococcus equi, Streptococcus pneumoniae 2125 VNGAGLAMAT Acinetobacter baylyi, Acinetobacter Q6F8L4, B0VEF2, Q96199 baumannii, Acinetobacter baumannii, A3M887, B7I6T2, Acinetobacter baumannii, B2HXG0, B7GXK7, Acinetobacter baumannii, B0VSL0, B2UMH5, Acinetobacter baumannii, A7GRG6, B7HDV9, Acinetobacter baumannii, B7IUJ5, Q9KA20, Akkermansia muciniphila, Bacillus Q6HEX9, B9IVC5, cytotoxicus, Bacillus cereus, Bacillus Q636J0, B7HLG9, cereus, Bacillus halodurans, Bacillus C1EP60, Q732N4, thuringiensis, Bacillus cereus, Bacillus A0RHK9, Q819X0, cereus, Bacillus cereus, Bacillus Q81WK0, C3L791, cereus, Bacillus cereus, Bacillus C3P5N7, Q5WFP4, thuringiensis, Bacillus cereus, Bacillus A9VT74, Q8A9M7, anthracis, Bacillus anthracis, Bacillus A8FKV6, Q5HVN3, anthracis, Bacillus clausii, Bacillus Q9PHY1, A1VYP2, weihenstephanensis, Bacteroides A7H4K9, A7GYI5, thetaiotaomicron, Campylobacter B3E7B3, B4RL77, jejuni, Campylobacter jejuni, Q9JUT0, Q9JZP4, Campylobacter jejuni, Campylobacter Q5F878, A1KTM6, jejuni, Campylobacter jejuni, A9M4F8, B2UGE2, Campylobacter curvus, Geobacter Q8Y1Y3, Q9EYG9, lovleyi, Neisseria gonorrhoeae, Q1MAW1, Q98EC5, Neisseria meningitidis, Neisseria B5ZSR9, Q2K3F0, meningitidis, Neisseria gonorrhoeae, B3PQ90, A5VB78, Neisseria meningitidis, Neisseria Q49X32, Q8CPH5, meningitidis, Ralstonia pickettii, Q5HPU5, B2FRS3, Ralstonia solanacearum, Rhizobium B4ST72 meliloti, Rhizobium leguminosarum, Rhizobium loti, Rhizobium leguminosarum, Rhizobium etli, Rhizobium etli, Sphingomonas wittichii, Staphylococcus saprophyticus, Staphylococcus epidermidis, Staphylococcus epidermidis, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 2126 VNGVAKIHSDI Bacillus subtilis P39123 P06737 2127 VNKSQSSND Escherichia coli, Escherichia coli, Q8X769, P05042, P07954 Escherichia coli Q8FHA7 2128 VNKSQSSNDT Haemophilus ducreyi Q7VKC9 P07954 2129 VNKSQSSNDTFPT Staphylococcus epidermidis, Q8CNR1, Q5HN85 P07954 AMH Staphylococcus epidermidis 2130 VNKSQSSNDTFPT Haemophilus influenzae P71384 P07954 AMHIAA 2131 VNLTNHSYFNL Acinetobacter calcoaceticus P05149 Q96C23 2132 VNQGHCHPKI Staphylococcus saprophyticus Q4A0N2 P04181 2133 VNRIAAGEV Sphingomonas wittichii A5V3J3 P40692 2134 VNTTDSAVR Eubacterium eligens, ptoclostridium C4Z154, Q180Y2, Q9UGC7 difficile, Clostridium phytofermentans, A9KHD4, C4XIQ1 Desulfovibrio maeticus 2135 VNTTDSAVRI Campylobacter curvus, A7GW12, A7ZB10, Q9UGC7 Campylobacter concisus, Q5HSH9, A1W1L4, Campylobacter jejuni, Campylobacter A8FNS3, Q9PM63, jejuni, Campylobacter jejuni, A7H5W3, A713Q0, Campylobacter jejuni, Campylobacter B9KE98, Q0SQY1, jejuni, Campylobacter hominis, Q0TNB0, Q8XIB9, Campylobacter lari, Clostridium A5N3J7, Q97F68, perfringens, Clostridium perfringens, Q7VFA0, B6JP10, Clostridium perfringens, Clostridium B5Z680, Q17VT1, kluyveri, Clostridium acetobutylicum, P55998, Q1CV77, Helicobacter hepaticus, Helicobacter Q9ZMZ0 pylori, Helicobacter pylori, Helicobacter acinonychis, Helicobacter pylori, Helicobacter pylori, Helicobacter pylori 2136 VNVQGTRNV Escherichia coli Q8X7P7 Q9H2F3 2137 VPAGVEDGQ Lactobacillus sakei, Lactobacillus O87778, Q38W94, Q96EY1 sakei, Pediococcus ntosaceus Q03FR6 2138 VPEEYGGLG Bacillus subtilis O32176 Q9H845 2139 VPESPRWLI Bacillus subtilis P94493 O75751 2140 VPETKGKTLE Escherichia coli, Escherichia coli P0AGF4, P0AGF5 Q9NY64 2141 VPETKGRSLEQ Bacillus subtilis P54723 Q9UGQ3 2142 VPGGFGIRG Lactobacillus delbrueckii Q04C51 Q9NRF8 2143 VPIGRGQRELIIGD Clostridium phytofermentans A9KK94 P25705 2144 VPIGRGQRELIIGD Fusobacterium nucleatum, Q8RGE0, A3DIM7, P25705 RQTGKT Clostridium thermocellum, Geobacter B3EA03, B9LZ86, lovleyi, Geobacter daltonii, Geobacter Q74GY2, A5G9D6, sulfurreducens, Geobacter C6E9F3, B5EFI9 uraniireducens, Geobacter sp., Geobacter bemidjiensis 2145 VPLIGFAGAP Bacillus pumilus, Listeria innocua, A8FBM5, Q929G1, P06132 Listeria monocytogenes, Listeria Q8Y564, A0AKW5, welshimeri, Listeria monocytogenes, Q71XF3, B8DF98, Listeria monocytogenes, Listeria C1KXG7 monocytogenes 2146 VPVGEELLGRVV Bacillus halodurans, Bacillus Q9K6H3, P22477 P25705 pseudofirmus 2147 VQSLGGTGALRI Haemophilus influenzae P44425 P17174 2148 VRENTEGEYSSL Escherichia coli, Pseudomonas putida P76251, Q51945 P51553 2149 VRFAPSPTG Desulfitobacterium hafniense Q250Q8 Q5JPH6 2150 VRFSTVAGE Bacteroides fragilis, Desulfovibrio P45737, Q9ZN99 P04040 vulgaris 2151 VRGGGRKPW Lactobacillus sakei, Enterococcus Q38UR3, Q839G3, Q9BYD3 faecalis, Pediococcus ntosaceus, Q03EB7, B9DM18, Staphylococcus carnosus, Q49ZG7, Q8CRG1, Staphylococcus saprophyticus, Q5HM00, Q4L8B3 Staphylococcus epidermidis, Staphylococcus epidermidis, Staphylococcus haemolyticus 2152 VRGKDVFIIQ Pseudomonas syringae, Q888C6, Q88PX6 O60256 Pseudomonas putida 2153 VRGVAMNPV Geobacter lovleyi, Geobacter B3E7T8, Q39Y03, P62917 metallireducens, Geobacter A5GAW8, Q8XV15 uraniireducens, Ralstonia solanacearum 2154 VRVRFAPSPTG Bacillus halodurans, Parabacteroides Q9KGF6, A6LEA1, Q5JPH6 distasonis, Bacteroides Q8A455, Q64NI3, thetaiotaomicron, Bacteroides fragilis, Q5L883, A6L0E8 Bacteroides fragilis, Bacteroides vulgatus 2155 VRVRFAPSPTGF ptoclostridium difficile Q18CD6 Q5JPH6 2156 VRVRFAPSPTGFL Finegoldia magna B0S0W2 Q5JPH6 H 2157 VSEAGASIYS Neisseria meningitidis, Neisseria P57072, Q51152, Q8N5C6 meningitidis, Neisseria gonorrhoeae Q51062 2158 VSEDMLGRVF Clostridium botulinum, Clostridium B2TP90, B2UWY3, P15313 botulinum, Clostridium tetani, Q896K3, Q0TPW8, Clostridium perfringens, Clostridium Q0SSI3, Q8XJW6, perfringens, Clostridium perfringens, A7GGL3, B1IJM7, Clostridium botulinum, Clostridium B1KXT5, C1FTN6, botulinum, Clostridium botulinum, A51556, A7FWQ6, Clostridium botulinum, Clostridium C3L1B0 botulinum, Clostridium botulinum, Clostridium botulinum 2159 VSGGTDNHL Aeromonas salmonicida, Aeromonas A4SJN4, A0KNH4 P34897 hydrophila 2160 VSHGATGKGNDQ Sphingomonas wittichii A5VAK5 P00966 VRFEL 2161 VSNHGGRQLD Acinetobacter baylyi, Acinetobacter Q6FFS1, B0VND0, Q9NYQ3 baumannii, Acinetobacter baumannii, B7IBS4, B0V6L1, Acinetobacter baumannii, A3M0X0, B2I061, Acinetobacter baumannii, B7H2H0, A8ARJ1, Acinetobacter baumannii, A4W540, B7NER0, Acinetobacter baumannii, Citrobacter P33232, B1IZ15, koseri, Enterobacter sp., Escherichia A8A670, B1X8M0, coli, Escherichia coli, Escherichia coli, C4ZXJ7, B1LK44, Escherichia coli, Escherichia coli, B6BI4, B7M492, Escherichia coli, Escherichia coli, B5YWA7, Q8XDF7, Escherichia coli, Escherichia coli, B7L725, A7ZTF9, Escherichia coli, Escherichia coli, B7N251, B7ULG1, Escherichia coli, Escherichia coli, Q1R4Z0, B7MFG9, Escherichia coli, Escherichia coli, Q8FCB1, Q0TBK1, Escherichia coli, Escherichia coli, B7NPB4, A1AHE2, Escherichia coli, Escherichia coli, B7LTL2, P46454, Escherichia coli, Escherichia coli, A5UFG9, A5UBE3, Escherichia fergusonii, Haemophilus Q4QJK8, Q7VPI9, influenzae, Haemophilus influenzae, A6TFK0, B5XMV0, Haemophilus influenzae, Q1IF69, B1J244, Haemophilus influenzae, A6VCM8, A5W9B2, Haemophilus ducreyi, Klebsiella Q88DT3, Q02FQ1, pneumoniae, Klebsiella pneumoniae, B0KIT4, Q9HV37, Pseudomonas entomophila, B7V113, Q4ZY06, Pseudomonas putida, Pseudomonas C3K053, B4SMK1, aeruginosa, Pseudomonas putida, B2FIJ0 Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas putida, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas syringae, Pseudomonas fluorescens, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 2162 VSNPVDILTY Clostridium acetobutylicum, Q97MD1, Q0SWR1, Q9BYZ2 Clostridium perfringens, Clostridium Q0TUX8, Q8XP62 perfringens, Clostridium perfringens 2163 VSNPVDILTYV Clostridium tetani Q892U0 Q9BYZ2 2164 VSSDRGLCG Geobacter uraniireducens, A5G9D7, Q88BX3, P36542 Pseudomonas putida, Pseudomonas A5WBA4, B0KRA9, putida, Pseudomonas putida, Q1I2I6, Q3K440, Pseudomonas entomophila, Q4ZL23, Q48BG4, Pseudomonas fluorescens, Q87TT3, B1JFU2, Pseudomonas syringae, C3K1E7, Q4K3A8, Pseudomonas savastanoi, B7V792, Q9HT19, Pseudomonas syringae, Q02DF3, A6VF33 Pseudomonas putida, Pseudomonas fluorescens, Pseudomonas fluorescens, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa 2165 VTAGLAIYDTMQYI Eubacterium rectale C4ZGF4 Q16740 2166 VTFHRAFDM Citrobacter koseri, Edwardsiella A8AFG8, C5B835, Q9NTM9 ictaluri, Enterobacter sp., Escherichia A4WBM9, B1LCZ7, coli, Escherichia coli, Escherichia coli, B7NS44, B5YR19, Escherichia coli, Escherichia coli, Q8XCH4, A8A176, Escherichia coli, Escherichia coli, B1J0L4, Q8FGQ2, Escherichia coli, Escherichia coli, Q0TGV9, B7USQ1, Escherichia coli, Escherichia coli, B7MW68, B7L7S7, Escherichia coli, Escherichia coli, B7NBM5, B6IIF2, Escherichia coli, Escherichia coli, P67826, B1XHE2, Escherichia coli, Escherichia coli, B7M2G5, C4ZQF8, Escherichia coli, Escherichia coli, A7ZNQ0, Q1RAR0, Escherichia coli, Escherichia coli B7MBT3, A1AC35 2167 VTGAAGQIAYSLL Akkermansia muciniphila, B2UKY5, P61974, P40925 Corynebacterium diphtheriae, Q8FN62 Corynebacterium efficiens 2168 VTGAAQGIGR Acinetobacter baylyi P07772 P15428 2169 VTGAGKGIG Escherichia coli P15047 Q7Z4W1 2170 VTGAGSGIG Staphylococcus aureus, Q8NUV9, Q6G6J1, Q92506 Staphylococcus aureus, Q99RF5, Q7A3L9, Staphylococcus aureus, Q6GDV6, Q2FVD5, Staphylococcus aureus, Q5HD73, Q2FE21 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 2171 VTGASRGIG Pseudomonas aeruginosa O54438 Q96LJ7 2172 VTGASRGIGR Bacillus subtilis, Escherichia coli P51831, P0AEK2 Q96LJ7 2173 VTGASSGIG Rhizobium sp., Staphylococcus P55434, Q4A054 Q9Y394 saprophyticus 2174 VTGASSGIGE Staphylococcus epidermidis, Q5HLD8, Q8CN40 Q9Y394 Staphylococcus epidermidis 2175 VTGSTSGIG Bacillus subtilis Q32229 Q13268 2176 VTILGHVQRGGTP Finegoldia magna B0S230 Q01813 2177 VTIMGHVDHGKT Rhizobium meliloti Q92SW4 P46199 2178 VTLELGGKNP Escherichia coli P80668 P43353 2179 VTLELGGKSP Bacillus subtilis, Bacillus subtilis, P46329, O34660, P51648 Pseudomonas oleovorans P12693 2180 VTLYHWDLPQ Bifidobacterium breve P94248 Q9UEF7 2181 VTTTTHKTLRG Lactobacillus sakei, Lactobacillus Q38WJ7, A5VIP9, P34897 reuteri, Lactobacillus reuteri, B2G679, A6LUK9, Clostridium beijerinckii, Clostridium A7GGI2, B1IJJ8, botulinum, Clostridium botulinum, B1KXQ5, C3L181, Clostridium botulinum, Clostridium C1FTF1, Q183G0, botulinum, Clostridium botulinum, A5I526, A7FWM6, ptoclostridium difficile, Clostridium Q9HVI7, P66804, botulinum, Clostridium botulinum, Q6G7J7, Q6GEW2, Pseudomonas aeruginosa, P66803, P99091, Staphylococcus aureus, A6QIV7, Q5HE87, Staphylococcus aureus, Q2FWE5, A5IUQ8, Staphylococcus aureus, A7X4V7, A6U3J8, Staphylococcus aureus, Q49Z60, Q2YUJ1, Staphylococcus aureus, A8YY80, Q2FF15, Staphylococcus aureus, Q4L7Z4, Q8CRN3, Staphylococcus aureus, Q5HMB0 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 2182 VVAGETGSGK Haemophilus influenzae P45018 Q7Z478 2183 VVAHRLSTV Streptomyces coelicolor Q9ZNB0 Q9NP58 2184 VVAIGECGLDF Citrobacter koseri, Citrobacter A8ACY8, D2TUZ4, Q6P1N9 rodentium, Enterobacter sp., A4WFX9, E3G381, Enterobacter liolyticus, Escherichia P27859, B7LTZ5, coli, Escherichia fergusonii, Klebsiella B5XYH5 pneumoniae 2185 VVDDLLATGGT Aeromonas hydrophila, Aeromonas A0KKD3, A4SMN3, P07741 salmonicida, Fusobacterium Q8RDM9, A8AJX4, nucleatum, Citrobacter koseri, A6LTN5, A4W7F3, Clostridium beijerinckii, Enterobacter Q8XD48, B5Z3X9, sp., Escherichia coli, Escherichia coli, B7LLQ1, Q1RF67, Escherichia fergusonii, Escherichia P69504, B1XFQ6, coli, Escherichia coli, Escherichia coli, Q0TKH2, B7M3W1, Escherichia coli, Escherichia coli, B1LJM6, B6I0C1, Escherichia coli, Escherichia coli, B7N922, C4ZUS3, Escherichia coli, Escherichia coli, B1IZC5, A1A8D5, Escherichia coli, Escherichia coli, B7NIG1, B7MDZ1, Escherichia coli, Escherichia coli, A7ZXC7, B7L794, Escherichia coli, Escherichia coli, P69503, B7UKE9, Escherichia coli, Escherichia coli, A7ZIM8, B7MQI4, Escherichia coli, Escherichia coli, Q7VKQ4, B5Y0N8, Haemophilus ducreyi, Klebsiella A6T5N2 pneumoniae, Klebsiella pneumoniae 2186 VVGNPANTN Acinetobacter baylyi, Acinetobacter Q6F7X1, B0V6R7, P40925 baumannii, Acinetobacter baumannii, A3M928, B2HZ52, Acinetobacter baumannii, B7I9D2, B7GW58, Acinetobacter baumannii, B0VQX5, Q8NN33, Acinetobacter baumannii, A4QGA0, Q8XXW5, Acinetobacter baumannii, B2U705, B2FQL8, Corynebacterium glutamicum, B4SLI5, Q9K3J3, Corynebacterium glutamicum, Q82HS2, B1W3N4 Ralstonia solanacearum, Ralstonia pickettii, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia, Streptomyces coelicolor, Streptomyces avermitilis, Streptomyces griseus 2187 VVGPEAPLAAGIV Ralstonia solanacearum Q8XXC4 P22102 2188 VVGTSSLRR Bacillus licheniformis, Desulfovibrio Q65GK1, C6BYB7, P08397 salexigens, Desulfovibrio alaskensis, Q30Y29, Q9JVS4, Neisseria meningitidis, Neisseria Q9K0P6, Q8XWW3 2189 VVIGADTIV meningitidis, Ralstonia solanacearum Bacillus pumilus A8FFU1 O95671 2190 VVILGQDPYHG Haemophilus somnus, Pseudomonas Q0I271, P29950, P13051 denitrificans, Ralstonia pickettii, B2UDL1, Q92LU5 Rhizobium meliloti 2191 VVILGQDPYHGPN Streptococcus thermophilus Q03KM6 P13051 QA 2192 VVILGQDPYHGPN Proteus mirabilis B4F058 P13051 QAHGL 2193 VVIVRDDLLG Pseudomonas stutzeri Q9R102 Q9Y617 2194 VVKHEVTGL Bacillus subtilis O34413 Q96MS3 2195 VVKRLPKTRSGK Pseudomonas aeruginosa P28812 Q9NUB1 2196 VVLAYSGGLDT Eubacterium rectale, C4Z9C9, B1VH30, P00966 Corynebacterium urealyticum, Q4JVZ8 Corynebacterium jeikeium 2197 VVLAYSGGLDTS Arcobacter butzleri, Lactobacillus A8EUB2, Q1WV65, P00966 salivarius, Bacillus halodurans, Q9K820, A8FG70, Bacillus pumilus, Bacillus Q65G67, Q5WED8, licheniformis, Bacillus clausii, Bacillus O34347, A7GTR5, subtilis, Bacillus cytotoxicus, Bacillus Q633G4, C1EUX9, cereus, Bacillus cereus, Bacillus A0RJM4, Q81KV7, thuringiensis, Bacillus anthracis, C3L9T6, C3PB97, Bacillus anthracis, Bacillus anthracis, A7Z7M0, Q6HCP7, Bacillus methylotrophicus, Bacillus B7JS06, B9J0E1, thuringiensis, Bacillus cereus, Bacillus P61520, A9VKE1, cereus, Bacillus cereus, Bacillus B7HRS7, Q817C6, weihenstephanensis, Bacillus cereus, B7H6Y5, B7IK29, Bacillus cereus, Bacillus cereus, B8FWX2, Q24ZG8, Bacillus cereus, Desulfitobacterium A0RP84, A7GYN4, hafniense, Desulfitobacterium A7I281, A7ZDF2, hafniense, Campylobacter fetus, Q9PHK7, B9KG97, Campylobacter curvus, A8FL83, A1VZ24, Campylobacter hominis, Q5HVA9, A7H4E9, Campylobacter concisus, A0Q1Z2, P59602, Campylobacter jejuni, Campylobacter A5N6U2, B9E0B1, lari, Campylobacter jejuni, Q186Z6, C1FU68, Campylobacter jejuni, Campylobacter A7GGQ9, A5I5A4, jejuni, Campylobacter jejuni, A7FWU6, C3L1U3, Clostridium novyi, Clostridium tetani, Q97KE6, B1KXY1, Clostridium kluyveri, Clostridium B1IK08, A6M1Z4, kluyveri, ptoclostridium difficile, P61521, Q8FTM9, Clostridium botulinum, Clostridium C4LIE1, Q30Y138, botulinum, Clostridium botulinum, B8DN64, P61522, Clostridium botulinum, Clostridium A1VEQ0, Q7VGU9, botulinum, Clostridium B2GKD7, Q4K749, acetobutylicum, Clostridium Q3K7K0, B7UW5, botulinum, Clostridium botulinum, Q9HY84, Q02QZ6, Clostridium beijerinckii, A6V1S1, Q48F14, Corynebacterium diphtheriae, Q87XM3, C3KBZ2, Corynebacterium efficiens, A4VIU7, Q4ZPK0, Corynebacterium kropnstedtii, A4XS43, B1J4I4, Desulfovibrio alaskensis, P59604, A5VZI0, Desulfovibrio vulgaris, Desulfovibrio Q11E03, B0KUE7, vulgaris, Desulfovibrio vulgaris, Q92L73, Q1MAN9, Helicobacter hepaticus, Kocuria Q2K3B7, Q98E81, rhizophila, Pseudomonas fluorescens, Q827Z1, B1W3B3, Pseudomonas fluorescens, P50986 Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas fluorescens, Pseudomonas stutzeri, Pseudomonas syringae, Pseudomonas mendocina, Pseudomonas putida, Pseudomonas putida, Pseudomonas putida, Pseudomonas entomophila, Pseudomonas putida, Rhizobium meliloti, Rhizobium leguminosarum, Rhizobium etli, Rhizobium loti, Streptomyces avermitilis, Streptomyces griseus, Streptomyces clavuligerus 2198 VVLGAQWGDEGK Clostridium novyi, Clostridium A0PXA8, Q8XH63, Q8N142 GK perfringens, Haemophilus somnus, Q0I4O5, B4SS80 Stenotrophomonas maltophilia 2199 VVLGHSERR Clostridium botulinum, Clostridium B2UY22, B2TPX3, P60174 botulinum, Clostridium beijerinckii A6LRO6 2200 VVLVGGSTR Corynebacterium glutamicum, A4QHJ0, Q8NLY6 P48723 Corynebacterium glutamicum 2201 VVPESPRWL Bacillus subtilis P96710 O75751 2202 VVTEAGFGAD Leuconostoc mesenteroides Q03YB1 P11586 2203 VVTIMGHVDHGKT Bacillus cereus, Bacillus cereus, B9IVA1, B7HLE6, P46199 TLLD Bacillus cereus, Bacillus anthracis, Q73209, Q81WM3, Bacillus anthracis, Bacillus anthracis, C3P5L5, C3L7B4, Bacillus thuringiensis, Bacillus cereus, Q6HF02, Q636L3, Bacillus thuringiensis, Bacillus cereus, A0RHI4, C1EP35, Bacillus cereus, Bacillus cereus, Q812X7, B7HDT6, Bacillus cereus, Bacillus cytotoxicus, B7IUH1, A7GRE3, Bacillus weihenstephanensis, A9VT50, B9DPF5, Staphylococcus carnosus, Q8C5T4, Q5HPS2, Staphylococcus epidermidis, Q49X54, P65134, Staphylococcus epidermidis, P65133, Q2YXP7, Staphylococcus saprophyticus, A5ISF3, A7X1Q1, Staphylococcus aureus, A6U188, Q6GHG6, Staphylococcus aureus, A8Z3U9, A6QGG8, Staphylococcus aureus, Q5HGG2, Q2G2D0, Staphylococcus aureus, Q2FHG9, Q8NWZ1, Staphylococcus aureus, Q6G9U4, Q4L5X1 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus 2204 VVVGPEAPL Streptomyces coelicolor Q9RKL4 P22102 2205 VVYGITTGFGKF Bacillus cereus, Bacillus cereus, Q733H8, Q637H8, P42357 Bacillus cereus, Bacillus anthracis, B7J180, Q81Y45, Bacillus anthracis, Bacillus anthracis, C3L982, C3P4M2, Bacillus cereus, Bacillus cytotoxicus, Q81AC6, A7GRO0, Bacillus weihenstephanensis, Bacillus A9VPT8, B7HCD0, cereus, Bacillus cereus, Bacillus B9IUH0, B7HKJ1, cereus, Bacillus thuringiensis, Bacillus Q6HFE9, B7I5J2, cereus, Bacillus thuringiensis, Bacillus A0RH39, C1EN93 cereus 2206 VWCSNDYLGM Rhizobium radiobacter, Rhizobium P26505, P08080 P22557 mel iloti 2207 VWQTGSGTQ Bacillus halodurans Q9KCX4 P07954 2208 VWVDLEMTGLD Corynebacterium glutamicum, Q8NMU1, A4QGM5, Q9Y3B8 Corynebacterium glutamicum, Q8FMX9 Corynebacterium efficiens 2209 VWVSEVMLQQT Bacillus subtilis O31584 Q9UIF7 2210 VYDQMPEPRYV Desulfovibrio desulfuricans B8J1D6 O75251 2211 VYGITTGFG Staphylococcus aureus, A8YYT1, A60D47, P42357 Staphylococcus aureus, Q5HJY8, Q2G2P7, Staphylococcus aureus, Q2FKP8, Q2YUR3, Staphylococcus aureus, Q8NYY3, Q6GD82, Staphylococcus aureus, P64416, P64415, Staphylococcus aureus, A5INP9, A6TXF8, Staphylococcus aureus, Q6GKT7 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 2212 WAHLDIAGV Desulfovibrio desulfuricans, B8J457, B7KYK4, P28838 Methylobacterium extorquens, A9VXD6, B1ZAK8, Methylobacterium extorquens, B1LVC3 Methylobacterium populi, Methylobacterium radiotolerans 2213 WAIGTGKTA Acinetobacter baumannii, B7H1F6, B2I2M3, P60174 Acinetobacter baumannii, B0VLU6, A3M1K0, Acinetobacter baumannii, B0VE65, B7I3R5, Acinetobacter baumannii, A8YUE4, Q5FL49, Acinetobacter baumannii, Q04BH0, Q1GB25, Acinetobacter baumannii, O32757, Q93GB7, Lactobacillus helveticus, Lactobacillus Q042F3, Q74K79, acidophilus, Lactobacillus delbrueckii, Q38Y19, B0S1G9, Lactobacillus delbrueckii, Q03GW6, P96985 Lactobacillus delbrueckii, Lactobacillus delbrueckii, Lactobacillus gasseri, Lactobacillus johnsonii, Lactobacillus sakei, Finegoldia magna, Pediococcus ntosaceus, Rhizobium etli 2214 WAIGTGKTAT Lactobacillus casei, Lactobacillus B3WCVV6, Q03AK5, P60174 casei, Lactobacillus salivarius, Q1WSX9, Q88YH4, Lactobacillus plantarum, Clostridium Q898R2, A5N2N7, tetani, Clostridium kluyveri, A0PYP2, A3DBQ1, Clostridium novyi, Clostridium B1KTJ6, A7FQN8, thermocellum, Clostridium botulinum, A7G9Y1, B1IDB7, Clostridium botulinum, Clostridium O52633, Q8XKU1, botulinum, Clostridium botulinum, Q0TQY8, Q0STD6 Clostridium acetobutylicum, Clostridium perfringens, Clostridium perfringens, Clostridium perfringens 2215 WAKQGVLLLN Campylobacter jejuni, Campylobacter Q5HX80, Q9PJ40, P13051 jejuni, Campylobacter jejuni, A1VXG9, A8FJP1, Campylobacter jejuni, Campylobacter B9KEK7 lari 2216 WAKQGVLLLNAVL Leuconostoc citreum B1MXY4 P13051 TV 2217 WCISRQLWWGH Campylobacter jejuni, Campylobacter Q5HV17, Q9PPE4, P26640 jejuni, Neisseria meningitidis, Q9JX22, Q5F5W0, Neisseria gonorrhoeae, Neisseria Q9K1H7 meningitidis 2218 WCISRQLWWGHR Helicobacter hepaticus Q7VHN2 P26640 IP 2219 WCISRQLWWGHR Bacillus cereus, Bacillus cereus, Q817R6, Q633Y6, P26640 IPA Bacillus cereus, Bacillus anthracis, Q72ZW8, Q81LD3, Bacillus thuringiensis, Q6HD68, B2FMS2, Stenotrophomonas maltophilia, B4SJ70 Stenotrophomonas maltophilia 2220 WCISRQLWWGHR Porphyromonas gingivalis, B2RK53, Q7MVD7 P26640 IPAY Porphyromonas gingivalis 2221 WCISRQLWWGHR Parabacteroides distasonis, A6LIG7, Q64XH6, P26640 IPAYF Bacteroides fragilis, Bacteroides Q5LGN1, Q89ZM4, fragilis, Bacteroides thetaiotaomicron, A6L3G7 Bacteroides vulgatus 2222 WDLRKTQPY Propionibacterium acnes Q6A6G1 O75306 2223 WDWVGGRYSLW Acinetobacter baumannii, A3M0W5, B2IQ56, P06744 S Acinetobacter baumannii, B0VMS2, B7H2H4, Acinetobacter baumannii, B0V6J2 Acinetobacter baumannii, Acinetobacter baumannii 2224 WDWVGGRYSLW Pseudomonas mendocina, A4XYC6, B0KHW6, P06744 SAIGL Pseudomonas putida, Pseudomonas B1J2C0, Q88DW7, putida, Pseudomonas putida, A5W976, Q88LW9, Pseudomonas putida, Pseudomonas Q1I4P0, A4VPM9, putida, Pseudomonas entomophila, Q3K6Q4, Q4K5Y1, Pseudomonas stutzeri, Pseudomonas C3K249, Q9HV67, fluorescens, Pseudomonas B7V1E4, Q02FU0, fluorescens, Pseudomonas A6VCI8, Q84814, fluorescens, Pseudomonas Q48N88, Q4ZY88, aeruginosa, Pseudomonas Q88807 aeruginosa, Pseudomonas aeruginosa, Pseudomonas aeruginosa, Pseudomonas fluorescens, Pseudomonas savastanoi, Pseudomonas syringae, Pseudomonas syringae 2225 WDYAHCLPYF Staphylococcus xylosus, Q9X2M2, Q4A0Q1 Q8NE62 Staphylococcus saprophyticus 2226 WIIDPIDGT Bacillus subtilis, Corynebacterium P29218 glutamicum Q45499, Q8NS80 2227 WKKNGWKTS Clostridium thermocellum A3DD79 O60930 2228 WLEVLGCGV Campylobacter lari B9KD77 O95363 2229 WLFDCGEGTQ Citrobacter koseri, Enterobacter sp., A8ADW5, A4WCQ3, Q9H777 Enterococcus faecalis, Escherichia Q834G2, B7MXV1, coli, Escherichia coli, Escherichia coli, B7NNU8, A1ADC0, Escherichia coli, Escherichia coli, Q1R9E5, Q8FFK8, Escherichia coli, Escherichia coli, B7MG36, Q0TFH3, Escherichia coli, Escherichia coli, B7N5N4, B617L2, Escherichia coli, Escherichia coli, A8A2D6, B1IXR8, Escherichia coli, Escherichia coli, P0A8V0, C4ZUB1, Escherichia coli, Escherichia coli, B7UFT1, B7M5V1, Escherichia coli, Escherichia coli, B7LAT4, A7ZP87, Escherichia coli, Klebsiella Q8XCZ0, B5XNW7, pneumoniae, Klebsiella pneumoniae, A6TBW1, A4WZ0, Streptococcus suis, Streptococcus A4W299, C1CQF2, suis, Streptococcus pneumoniae, C1CJE0, B2IMY3, Streptococcus pneumoniae, B1IAL2, C1C636, Streptococcus pneumoniae, C1CD41, Q8DQN1, Streptococcus pneumoniae, Q97RW2, B8ZMQ6, Streptococcus pneumoniae, Q04LL3, B5E2R6 Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae 2230 WLHVDAAWGG Haemophilus influenzae P71362 Q9Y600 2231 WLTGLSGAGK Pseudomonas aeruginosa P57702 Q43252 2232 WNDMNEPSVFN Bacillus thermoamyloliquefaciens Q9F234 Q14697 2233 WPMTFGLACCA Geobacter uraniireducens, Geobacter A5G9B8, B5EFG2, bemidjiensis, Geobacter daltonii, B9LZL8, C6E8N4, O75251 Geobacter sp., Geobacter Q74GA7, Q39QA8, sulfurreducens, Geobacter B3E9W8 metallireducens, Geobacter lovleyi 2234 WPMTFGLACCAV Stenotrophomonas maltophilia, B2FNX8, B45QT5 O75251 EMMH Stenotrophomonas maltophilia 2235 WQTGSGTQTNMN Helicobacter pylori, Helicobacter Q9ZJQ9, O25883 P07954 pylori 2236 WRLNERHYG Lactobacillus sakei, Lactobacillus Q38Z74, Q38ZH8, sakei, Fusobacterium nucleatum, Q8RFG9, B3DQI6, P15259 Bifidobacterium longum, B7GUR7, P59159, Bifidobacterium longum, Q4JSW4, Q6NJL2, Bifidobacterium longum, C4LLD4, Q8FSH0, Corynebacterium jeikeium, A40B41, Q8NTA5, Corynebacterium diphtheriae, A1VAI9, Q727C0, Corynebacterium kropnstedtii, Q839H4, Q74CR0, Corynebacterium efficiens, C6E639, B5EC38, Corynebacterium glutamicum, B8F5J4, P44865, Corynebacterium glutamicum, Q40ME2, A5UDW8, Desulfovibrio vulgaris, Desulfovibrio A5UHR1, Q0I4D8, vulgaris, Enterococcus faecalis, Q7VL28, Q929G8, Geobacter sulfurreducens, Geobacter A0AKV8, B8DFA5, sp., Geobacter bemidjiensis, Q8Y571, Q71XG0, Haemophilus parasuis, Haemophilus C1KXG0, Q6AAU8, influenzae, Haemophilus influenzae, Q4L8T0, A2RDV4, Haemophilus influenzae, P0DD06, Q1JAX0, Haemophilus influenzae, B5XM69, Q1JL20, Haemophilus somnus, Haemophilus Q1JG44, P65711, ducreyi, Listeria innocua, Listeria P0DD07, Q5X1388, welshimeri, Listeria monocytogenes, Q1J5W1, Q485P2, Listeria monocytogenes, Listeria Q99Z29, B1VS80, monocytogenes, Listeria P33158, Q82GB8 monocytogenes, Propionibacterium acnes, Staphylococcus haemolyticus, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptococcus pyogenes, Streptomyces griseus, Streptomyces coelicolor, Streptomyces avermitilis 2237 WRLNERHYGGL Desulfovibrio maeticus, Desulfovibrio C4XIQ5, B8DLN4, P15259 vulgaris, Staphylococcus Q49ZZ2, B9DL85, saprophyticus, Staphylococcus Q8CN61, Q5HLI0, carnosus, Staphylococcus Q6GE17, A5IVJ6, epidermidis, Staphylococcus A8YYG4, Q5HDD9, epidermidis, Staphylococcus aureus, P65709, A6U4E6, Staphylococcus aureus, Q2FE81, A7X656, Staphylococcus aureus, Q6G605, A6QJQ5, Staphylococcus aureus, Q2FVK8, P65708, Staphylococcus aureus, P99153, Q2YVZ6, Staphylococcus aureus, B2FHH6, B4SPL6 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 2238 WRLNERHYGGLT Streptococcus agalactiae, Q3K1U2, Q8E643, P15259 G Streptococcus agalactiae, Q8E0G9, P59161, Streptococcus agalactiae, B9DUS6, B4U1Y5, Streptococcus mutans, Streptococcus C0MCW5, C0M8R8 uberis, Streptococcus equi, Streptococcus equi, Streptococcus equi 2239 WRLNERHYGGLT Streptococcus suis A4W369 P15259 GLNKAE 2240 WRLNERHYGGLT Sphingomonas wittichii A5VB15 P15259 GLNKAETAA 2241 WSLLDNFEW Clostridium thermocellum P26208 Q9H227 2242 WSSCNIFSTQD Pseudomonas aeruginosa, Q9I685, B7V419, P23526 Pseudomonas aeruginosa, Q02TY0, A4VRF7, Pseudomonas aeruginosa, A4XPF3 Pseudomonas stutzeri, Pseudomonas mendocina 2243 WTTTPWTLP Acinetobacter baylyi, Aeromonas Q6FG02, A0KG39, P41252 hydrophila, Aeromonas salmonicida, A4S1X5, A8E562, Arcobacter butzleri, Bacillus cereus, Q81E30, Q739A1, Bacillus cereus, Bacillus thuringiensis, A0RDG3, Q6HJF2, Bacillus thuringiensis, Bacillus Q81R75, Q63BZ8, anthracis, Bacillus cereus, Bacillus Q6HER9, C1EPQ9, thuringiensis, Bacillus cereus, Bacillus B7JJY2, Q636D1, cereus, Bacillus cereus, Bacillus B7H6N1, Q819R4, cereus, Bacillus cereus, Bacillus Q732H4, B9IVX2, cereus, Bacillus cereus, Bacillus B7HLM9, B7IUQ5, cereus, Bacillus cereus, Bacillus C3L730, C3P665, anthracis, Bacillus anthracis, Bacillus Q81WE4, A9VTD5, anthracis, Bacillus A7GRM0, B8FT35, weihenstephanensis, Bacillus Q24TH1, Q8RH47, cytotoxicus, Desulfitobacterium A7GX26, A8Z6P6, hafniense, Desulfitobacterium A8ALT6, Q72AR5, hafniense, Fusobacterium nucleatum, A1VCU3, B8DPD6, Campylobacter curvus, B8J3R3, C5B7M4, Campylobacter concisus, Citrobacter Q836V1, Q0TLW5, koseri, Desulfovibrio vulgaris, B7UI71, Q1RGH6, Desulfovibrio vulgaris, Desulfovibrio Q8FLB7, A1A774, vulgaris, Desulfovibrio desulfuricans, B7MNN1, B7MAE6, Edwardsiella ictaluri, Enterococcus B1LFV6, B7NHD0, faecalis, Escherichia coli, Escherichia B7N7Q0, B1IRE9, coli, Escherichia coli, Escherichia coli, B7LVN2, A7ZHB5, Escherichia coli, Escherichia coli, B6HZ21, P00956, Escherichia coli, Escherichia coli, B1XBF1, C4ZPV2, Escherichia coli, Escherichia coli, B7M0C2, B7L4E8, Escherichia coli, Escherichia B5YYB8, Q8XA49, fergusonii, Escherichia coli, A7ZVX4, Q7VGX8, Escherichia coli, Escherichia coli, B5Y235, A9M1J7, Escherichia coli, Escherichia coli, Q9JVY4, Q5FAF5, Escherichia coli, Escherichia coli, A1KS62, Q9JXY7, Escherichia coli, Escherichia coli, B4RPY6, B4F2T5, Escherichia coli, Helicobacter P41368, B4SP18, hepaticus, Klebsiella pneumoniae, B2FTJ0 Neisseria meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria meningitidis, Neisseria meningitidis, Neisseria gonorrhoeae, Proteus mirabilis, Staphylococcus aureus, Stenotrophomonas maltophilia, Stenotrophomonas maltophilia 2244 WTTTPWTLPSN Haemophilus somnus, Haemophilus Q0I1V8, B8F5E2, P41252 parasuis, Staphylococcus Q49WX5, B9DPP7 saprophyticus, Staphylococcus carnosus 2245 WVEPELRGV Rhizobium leguminosarum Q1MHI4 O14782 2246 WVGGRYSLWS Acinetobacter baumannii B7IBR9 P06744 2247 WVLGEHGDSS Lactobacillus delbrueckii Q04CN9 P00338 2248 WVQIFENKGA Haemophilus influenzae P31764 P07902 2249 WYDNEFGYS Pseudomonas aeruginosa Q02PG5 P04406 2250 YAEALREVSAA ptoclostridium difficile Q184E3 P15313 2251 YAEALREVSAAR Fusobacterium nucleatum, Q8RI79, A3DHP1 P15313 Clostridium thermocellum 2252 YARGAQDMK Campylobacter fetus A0RNM0 Q03154 2253 YATRDLAAA Clostridium perfringens, Clostridium Q8XJU2, A6L573, Q5T160 beijerinckii, Clostridium botulinum, B2UW74, B1KYT1, Clostridium botulinum, Clostridium Q97K78 acetobutylicum 2254 YATRDLAAAI Clostridium kluyveri, Clostridium A5N8F9, B9E1W5, Q5T160 kluyveri, Clostridium botulinum, B1I1E6, A7GCB9, Clostridium botulinum, Clostridium C1FK28, C3KSZ0, botulinum, Clostridium botulinum, A5IQR5, A7FSW7 Clostridium botulinum, Clostridium botulinurn 2255 YCGFDPTADS Bacillus caldotenax, Bacillus P04077, Q6HCM0, Q9Y2Z4 thuringiensis, Bacillus cereus, Bacillus Q633D2, Q81KS9, anthracis, Bacillus cereus, Bacillus Q72Z73, Q817A2, cereus, Desulfitobacterium hafniense, Q251G4, B8G0N6, Desulfitobacterium hafniense, A8AH18, A4W9W0, Citrobacter koseri, Enterobacter sp., B7LQN3, B1LEP9, Escherichia fergusonii, Escherichia B6IB76, B7NB91, coli, Escherichia coli, Escherichia coli, P0AGJ9, B1IQB7, Escherichia coli, Escherichia coli, C4ZYA0, A8A010, Escherichia coli, Escherichia coli, B1XFU9, B7NTZ5, Escherichia coli, Escherichia coli, B5Z471, P0AGK0, Escherichia coli, Escherichia coli, A7ZM99, B7M0J4, Escherichia coli, Escherichia coli, Q8FH88, B7MVB5, Escherichia coli, Escherichia coli, B7L5J0, B7M9Z1, Escherichia coli, Escherichia coli, B7URX8, Q1RBF8, Escherichia coli, Escherichia coli, A1ABI2, B5XWP0, Escherichia coli, Klebsiella A6T9Y5, A9M1J5, pneumoniae, Klebsiella pneumoniae, A1KS60, Q9JXY5, Neisseria meningitidis, Neisseria Q9JVY6, B4RP13, meningitidis, Neisseria meningitidis, Q5FAF7 Neisseria meningitidis, Neisseria gonorrhoeae, Neisseria gonorrhoeae 2256 YCIVPFTRG Staphylococcus haemolyticus, Q4L5Z6, Q8CSS3, Q965Z6 Staphylococcus epidermidis, Q5HPP8, Q6GHE3, Staphylococcus epidermidis, Q2YXS2, Q7A110, Staphylococcus aureus, Q6G951, Q7A5W3, Staphylococcus aureus, Q99UI1, A5ISH6, Staphylococcus aureus, A6U1B1, A7X1T3, Staphylococcus aureus, A8Z1W3, Q2FZ02, Staphylococcus aureus, A6QGJ1, Q5HGD9, Staphylococcus aureus, Q2FHE6, Q49X85 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus saprophyticus 2257 YCLGPTHEE Desulfovibrio alaskensis, Q30Z93, C6BYX7, Q7L3T8 Desulfovibrio salexigens, A1VE74, Q72CD8, Desulfovibrio vulgaris, Desulfovibrio B8DNM5 vulgaris, Desulfovibrio vulgaris 2258 YCTGGIRCE Bacillus clausii, Bacillus cereus, Q5WEM1, B9IX93, Q5T7W7 Bacillus cereus, Bacillus B7HMP7, A9VQI6, weihenstephanensis, Bacillus cereus, C1EQF9, A0RCP2, Bacillus thuringiensis, Bacillus A7GNS3, Q73A25, cytotoxicus, Bacillus cereus, Bacillus B7HIR1, Q81F03, cereus, Bacillus cereus, Bacillus C3L6L9, C3P778, anthracis, Bacillus anthracis, Bacillus B7JJJ3, Q81S00, cereus, Bacillus anthracis, Bacillus Q6HK75, Q63CS8, thuringiensis, Bacillus cereus, Bacillus B7IS63, Q65EW5, cereus, Bacillus licheniformis, Q6NEH3, Q8FLN8, Corynebacterium diphtheriae, C3PKD8, Q8NLF0, Corynebacterium efficiens, A4QI35, C4LG97, Corynebacterium aurimucosum, Q837T2, B2GKC1, Corynebacterium glutamicum, Q8Y7A4, B8DFU3, Corynebacterium glutamicum, Q71ZT6, C1L2U0, Corynebacterium kropnstedtii, A0AII6, Q92BX1, Enterococcus faecalis, Kocuria Q4A0W6, B9DJ55, rhizophila, Listeria monocytogenes, A6U574, A5IW36, Listeria monocytogenes, Listeria P67326, A7X781, monocytogenes, Listeria P67327, Q5HCK8, monocytogenes, Listeria welshimeri, Q8NUH3, Q6G5Y5, Listeria innocua, Staphylococcus Q6GDB5, Q2YZA3, saprophyticus, Staphylococcus Q2FUS7, A8Z5J0, carnosus, Staphylococcus aureus, Q2FDH2, A6QKH7, Staphylococcus aureus, Q4L9R7, Q8CTV8, Staphylococcus aureus, Q5HKM8 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus epidermidis, Staphylococcus epidermidis 2259 YDLTSKPPGT Eubacterium rectale, Eubacterium C4ZCQ4, C4Z3X1 P49915 eligens 2260 YDLVLNGNE Desulfovibrio alaskensis Q317R3 Q6PI48 2261 YGITTGFGKF Bacillus methylotrophicus, Bacillus A7ZAE4, Q9KBE6 P42357 halodurans 2262 YGITTGFGKFA Fusobacterium nucleatum Q8RFC2 P42357 2263 YGPPGTGKT Micrococcus luteus C5CBU4 Q6PL18 2264 YGPPGVGKT Bacillus subtilis P42425 P36776 2265 YGPPGVGKTS Parabacteroides distasonis, A6LD45, O69300, P36776 Campylobacter jejuni, Porphyromonas B2RI16 gingivalis 2266 YICGEETALI Escherichia coli P31979 P49821 2267 YIEAHGTGT Bacillus subtilis, Bacillus subtilis Q05470, O31782 P49327 2268 YIGVLIDDL Bacillus cytotoxicus, Bacillus cereus, A7GVP6, Q814F7, Q9Y2Z2 Bacillus cereus, Bacillus Q72WU4, A9VTL9, weihenstephanensis, Bacillus Q6HAF3, Q63069, thuringiensis, Bacillus cereus, Bacillus Q81JH3, A0RLR1, anthracis, Bacillus thuringiensis, Q040F4, Q74H95, Lactobacillus gasseri, Lactobacillus A0AMD1, Q8Y3M5, johnsonii, Listeria welshimeri, Listeria Q71VV1, Q926U8, monocytogenes, Listeria Q4L2Z3, Q49UI5, monocytogenes, Listeria innocua, Q8CMN6, Q5HS35, Staphylococcus haemolyticus, Q2YZB9, P64231, Staphylococcus saprophyticus, Q6G5W5, Q6GD93, Staphylococcus epidermidis, P64230, P64229, Staphylococcus epidermidis, A7X7A7, A5IW06, Staphylococcus aureus, A6U594, A8YYS0, Staphylococcus aureus, A6QKK1, Q5HCI4, Staphylococcus aureus, Q2FUQ3, Q2FDE9 Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus, Staphylococcus aureus 2269 YINSPGGWT Arcobacter butzleri, Campylobacter A8EVH5, B9KDZ6, Q16740 lari, Campylobacter hominis, A7HZE8, Q982V6, Rhizobium loti, Rhizobium loti Q98M38 2270 YINSPGGWTAG Rhizobium etli, Rhizobium Q2K9U7, Q1MIM7, Q16740 leguminosarum, Rhizobium meliloti P58278 2271 YINSPGGWTAGL Haemophilus ducreyi Q7VP78 Q16740 AIYDTM 2272 YITPVPGGVGPMT Bacteroides vulgatus, A6L2G2, A6L8J2, P13995 Parabacteroides distasonis, Q0PA35, A8FLR4, Campylobacter jejuni, Campylobacter A1VZJ8, Q5HUU1, jejuni, Campylobacter jejuni, Q7MVE9 Campylobacter jejuni, Porphyromonas gingivalis 2273 YLDLYLIHWP Bacillus subtilis, Bacillus subtilis O34678, O32210 Q96JD6 2274 YLRPETAQGIF Eubacterium rectale, Bifidobacterium C4ZAV7, Q8G7W9, P41250 longum, Clostridium kluyveri, A5N4L2, B9DY74, Clostridium kluyveri, Clostridium Q97EB8, Q8XHL9, acetobutylicum, Clostridium A9KJ36, A6LPL6, perfringens, Clostridium B8I2Z6, A3DF15, phytofermentans, Clostridium Q8FNG6, Q8NNC6, eijerinckii, Clostridium cellulolyticum, C4Z1I4, Q6A964, Clostridium thermocellum, Q9L2H9, Q82BR9 Corynebacterium efficiens, Corynebacterium glutamicum, Eubacterium eligens, Propionibacterium acnes, Streptomyces coelicolor, Streptomyces avermitilis 2275 YLVMEYVPG Bacillus anthracis Q81WH6 P22612 2276 YNKDLQEDKE Lactobacillus plantarum, Lactobacillus P59617, B2GE78, P04424 fermentum, Lactobacillus salivarius, Q1WV66, C1KX44, Listeria monocytogenes, Listeria Q71XS3, B8DH27, monocytogenes, Listeria Q8Y5H1, Q929S8, monocytogenes, Listeria A0AKJ8, Q8DVX5, monocytogenes, Listeria innocua, B9DW8, Q03IP9, Listeria welshimeri, Streptococcus Q5M2K3, Q5LXZ9, mutans, Streptococcus uberis, A3CQQ3, A8AUN7, Streptococcus thermophilus, C1CAC7, C1CBS9, Streptococcus thermophilus, Q8DRI4, B1I815, Streptococcus thermophilus, Q04MW6, Q8E271, Streptococcus sanguinis, Q3K3Q3, Q8E7N0 Streptococcus gordonii, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus agalactiae, Streptococcus agalactiae, Streptococcus agalactiae 2277 YPLNPNGSP Ralstonia solanacearum Q8XYN6 O15067 2278 YQDQKPGTSGLR Rhizobium radiobacter P39671 P36871 K 2279 YQIYPRSFKD Streptococcus dysgalactiae Q59905 Q07837 2280 YQIYPRSFKDSN Bacillus subtilis O05242 Q07837 2281 YQRLEFLGD Leuconostoc mesenteroides, Q03VW5, B1N016, Q9UPY3 Leuconostoc citreum, Rhizobium sp., C3M854, Q92R47 Rhizobium meliloti 2282 YQWYLDLRR Lactobacillus sakei Q38X65 Q96159 2283 YRDDGLLVW Pseudomonas aeruginosa, Q9I4G8, Q8RNT4 P09917 Pseudomonas aeruginosa 2284 YRIDHYLGKE Escherichia coli, Escherichia coli, O8XCJ6, P0AC53, P11413 Escherichia coli P0AC54 2285 YRKLALKYHPD Helicobacter pylori, Helicobacter O25890, Q9ZJQ2 Q8WW22 pylori 2286 YRLALQTREQHIR Ralstonia pickettii, Ralstonia B2UG82, Q8XU98 P23378 R solanacearum 2287 YRLALQTREQHIR Rhizobium loti Q98LT6 P23378 RDKATSNICTAQA LLANMA 2288 YRQRYLDLI Lactobacillus plantarum, Lactobacillus Q88Z28, B2GA78, Q15046 fermentum, Lactobacillus sakei, Q38V83, Q03E09 Pediococcus ntosaceus 2289 YSALKKDGQ Pseudomonas aeruginosa, A6VCJ9, P72154, Q8WWH5 Pseudomonas aeruginosa, Q02FT0, A4XYD8 Pseudomonas aeruginosa, Pseudomonas mendocina 2290 YSAVNQGHCHPKI Bacillus halodurans Q9K5Z2 P04181 2291 YTAIEAPKGE Geobacter uraniireducens A5GCZ4 O75306 2292 YTHFTSPIRR Bacillus subtilis, Helicobacter pylori, O32231, P56123, Q8IYB7 Helicobacter pylori Q9ZJX9 2293 YTPYQPEVSQGR Citrobacter koseri, Edwardsiella A8APB1, C5BAT0, P23378 LE ictaluri, Enterobacter sp., Escherichia A4WE55, Q1R7C8, coli, Escherichia coli, Escherichia coli, B7MZ55, B7MM89, Escherichia coli, Escherichia coli, B7UHV1, Q0TDU9, Escherichia coli, Escherichia coli, B7LYG7, A7ZR12, Escherichia coli, Escherichia coli, Q8FE67, B7N7E6, Escherichia coli, Escherichia coli, B7NHW4, B1LDA3, Escherichia coli, Escherichia coli, A1AF92, Q8XD33, Escherichia coli, Escherichia B5YQ95, B7LPB7, fergusonii, Escherichia coli, P33195, C5A0H5, Escherichia coli, Escherichia coli, B1XEJ0, B61736, Escherichia coli, Escherichia coli, A8A444, B7LF89, Escherichia coli, Escherichia coli B1IT99 2294 YTPYQPEVSQGR Klebsiella pneumoniae, Klebsiella A6TDR5, B5XUD5, P23378 LESLLN pneumoniae, Proteus mirabilis B4F0N7 2295 YTRREPLGVC Rhizobium meliloti Q92YD2 P49189 2296 YTSGSTGKPKGV Aneurinibacillus migulanus, Bacillus P00063, P39847, Q9NR19 subtilis, Bacillus subtilis, Bacillus Q9R9I9, Q04747, subtilis, Bacillus subtilis, Bacillus Q9R9J0, P40806 subtilis 2297 YTSGSTGMPKG Bacillus licheniformis, Bacillus subtilis O68008, P94459 Q9NUB1 2298 YTSGSTGRPKGV Bacillus subtilis, Streptomyces niveus P45745, Q9L9G0 O60488 2299 YTSGTTGLPKG Pseudomonas sp. A5JTM6 Q9H6R3 2300 YTSGTTGNPKG Aneurinibacillus migulanus P00061 Q96GR2 2301 YTSGTTGNPKGV Pseudomonas oleovorans Q00594 Q96GR2 2302 YTSGTTGNPKGV Bacillus licheniformis Q68007 Q96GR2 M 2303 YTSVLKRAI Citrobacter koseri, Edwardsiella A8AJ40, C5BEL3, P15259 ictaluri, Enterobacter sp., Escherichia A4W897, P62708, coli, Escherichia coli, Escherichia coli, B7N9Z7, B7NNH7, Escherichia coli, Escherichia coli, B1LM46, B7M6B8, Escherichia coli, Escherichia P62707, B7LK04, fergusonii, Escherichia coli, B617Q9, Q0TJU6, Escherichia coli, Escherichia coli, B1X786, B5YRF2, Escherichia coli, Escherichia coli, B7MPN9, A7ZY11, Escherichia coli, Escherichia coli, B1IXY1, B7LAF6, Escherichia coli, Escherichia coli, P62709, C4ZXS6, Escherichia coli, Escherichia coli, A1A8Z8, B7MGL2, Escherichia coli, Escherichia coli, B7ULM8, A7ZJD0, Escherichia coli, Geobacter Q39V40, B5XZB2, metallireducens, Klebsiella A6T6I3, B4EST0, pneumoniae, Klebsiella pneumoniae, Q03KA9, Q8VVB5, Proteus mirabilis, Streptococcus Q5LZF1, C1C8P5, thermophilus, Streptococcus C1CFM7, P0A3Y4, thermophilus, Streptococcus P0A3Y3, B1I720, thermophilus, Streptococcus B5E706, Q04JB4, pneumoniae, Streptococcus A3CLS0, C1CLZ5, pneumoniae, Streptococcus B8ZM52, C1CSS1, pneumoniae, Streptococcus B2IRR1, A8AW46, pneumoniae, Streptococcus B1GZZ1 pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus sanguinis, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus pneumoniae, Streptococcus gordonii, Uncultured termite 2304 YTSVLKRAIRTL Clostridium acetobutylicum Q97FJ6 P15259 2305 YTSVLKRAIRTLW Bacillus cereus, Bacillus cereus, Q737X5, Q81DD2, P15259 Bacillus cereus, Bacillus cereus, B7IX37, B9J102, Bacillus cereus, Bacillus cereus, B7H546, B7H7P4, Bacillus anthracis, Bacillus anthracis, Q6KSL4, C3PAW8, Bacillus anthracis, Bacillus cereus, C3LIE5, B7JPK2, Bacillus cereus, Bacillus thuringiensis, Q63692, A0RE96, Bacillus cereus, Bacillus thuringiensis, C1EUQ5, Q6HIL9, Bacillus cytotoxicus, Bacillus A7GPN5, A9VFW9, weihenstephanensis, Clostridium A6LUA1, Q8Y2I3 beijerinckii, Ralstonia solanacearum 2306 YVEGESLLM Pseudomonas putida, Pseudomonas B1JDR3, Q1IEJ2, Q9Y697 entomophila, Pseudomonas putida, Q88PK8, A5VYS4, Pseudomonas putida, Pseudomonas B0KPH6 putida 2307 YVGCGERGNEM Enterococcus faecalis Q834X9 P38606 2308 YVHRIGRTGR Aeromonas hydrophila, Aeromonas A0KEG9, A4STJ7, Q9UJV9 salmonicida, Citrobacter koseri, A8ACT3, A4WG30, Enterobacter sp., Escherichia coli, P25888, B5YY28, Escherichia coli, Escherichia coli, Q8XAT4, B7LU75, Escherichia fergusonii, Escherichia B7NTG2, P0A8J8, coli, Escherichia coli, Escherichia coli, Q1R4F9, B6I4B6, Escherichia coli, Escherichia coli, C4ZZ48, B1IWC0, Escherichia coli, Escherichia coli, Q0TAU3, P0A8J9, Escherichia coli, Escherichia coli, A1AHV0, A8A6N4, Escherichia coli, Escherichia coli, B1X9Z4, B7M5C7, Escherichia coli, Escherichia coli, B7MR01, B7L8B6, Escherichia coli, Escherichia coli, A7ZTY2, B7MGJ1, Escherichia coli, Escherichia coli, B7UMN5, B7NF85, Escherichia coli, Escherichia coli, B1LLV3, Q8XA87, Escherichia coli, Escherichia coli, P0A9P6, P0A9P7, Escherichia coli, Haemophilus Q0I1X0, P44586, somnus, Haemophilus influenzae, A5UI36, P44922, Haemophilus influenzae, A5UDI1, A6TGG9, Haemophilus influenzae, B5XYY9, P33906, Haemophilus influenzae, Klebsiella B4F1V3 pneumoniae, Klebsiella pneumoniae, Klebsiella pneumoniae, Proteus mirabilis 2309 YVHRVGRTARAG Bacillus subtilis P54475 Q8N8A6 2310 YVNDAFGTAHRA Bacteroides thetaiotaomicron, Q8A753, Q7MU77 P07205 H Porphyromonas gingivalis 2311 YVYIIYGMY Clostridium perfringens, Clostridium Q8XHA9, Q0SPY0, P29372 perfringens, Clostridium perfringens Q0TM75 2312 YWHFVDWW Corynebacterium diphtheriae, Q6NGA0, Q9AEL8, P00414 Corynebacterium glutamicum, Q8FN09, Q9X809, Corynebacterium efficiens, Q82AK5 Streptomyces coelicolor, Streptomyces avermitilis 2313 YWLSGLTCTEQN Haemophilus influenzae P44556 P10768 FI

TABLE 2 Nucleic acid sequences encoding drug-metabolizing gene products (identified by start nucleotide and end nucleotide in the listed contigs in the mentioned bacterial species, as disclosed in Zimmermann et al. (2019) Nature 570(7762): 462-467). NCBI_NUCCORE_ID SPECIES START END CVOZ01000027.1 Bacteroides thetaiotaomicron 37953 39176 CVOZ01000054.1 Bacteroides thetaiotaomicron 11293 10091 CVOZ01000070.1 Bacteroides thetaiotaomicron 209 1357 JGCP01002329.1 Bacteroides fragilis 4469 5122 JGCP01002329.1 Bacteroides fragilis 3779 5098 NC_000913.3 Escherichia coli 4581453 4580197 NC_009614.1 Bacteroides vulgatus 4257974 4256682 NC_009614.1 Bacteroides vulgatus 4556425 4555544 NC_012781.1 Eubacterium rectale 2288771 2288262 NC_012781.1 Eubacterium rectale 784939 786126 NC_012781.1 Eubacterium rectale 1283259 1283786 NZ_AAVM02000005.1 Bacteroides caccae 114685 114182 NZ_ACEP01000037.1 Eubacterium hallii 7170 8357 NZ_DS264584.1 Bacteroides ovatus 814601 813570 NZ_DS544184.1 Anaerotruncus colihominis 120271 119024 NZ_DS544185.1 Anaerotruncus colihominis 210646 210155 NZ_DS981517.1 Clostridium sporogenes 1624155 1624691 NZ_DS981517.1 Clostridium sporogenes 2067986 2066751 NZ_DS990240.1 Bifidobacterium longum 215669 216163 NZ_DS995528.1 Bacteroides dorei 145200 143932 NZ_DS995531.1 Bacteroides dorei 422777 421590 NZ_DS996451.1 Parabacteroides johnsonii 204827 205366 NZ_DS996841.1 Holdemanella biformis 520281 520754 NZ_DS996921.1 Bacteroides pectinophilus 1435212 1434652 NZ_GG667612.1 Hungatella hathewayi 20416 21654 NZ_GG703853.1 Prevotella copri 461595 462476 NZ_GG739634.1 Edwardsiella tarda 123662 122379 NZ_JH370372.1 Alistipes indistinctus 576953 575652 NZ_JH724294.1 Bacteroides xylanisolvens 756855 758042 NZ_MTWC01000003.1 Clostridioides difficile 3445824 3444499 NZ_MTWF01000021.1 Clostridioides difficile 518815 517457 NZ_PPUH01000002.1 Eggerthella lenta 280904 279747 NZ_PUEP01000005.1 Bacteroides ovatus 2631144 2632175 NZ_PUEQ01000002.1 Bacteroides caccae 481569 481066 QEKH01000037.1 Victivallis vadensis 16258 17517 QEKH01000037.1 Victivallis vadensis 16252 16887 CVOZ01000028.1 Bacteroides thetaiotaomicron 3250 2549 CVOZ01000054.1 Bacteroides thetaiotaomicron 13292 11376 JGCP01000504.1 Bacteroides fragilis 6097 5297 JGCP01002329.1 Bacteroides fragilis 1730 3721 NC_000913.3 Escherichia coli 4582670 4581897 NC_009614.1 Bacteroides vulgatus 4260288 4258765 NC_009614.1 Bacteroides vulgatus 4559064 4558243 NC_009614.1 Bacteroides vulgatus 5131510 5130809 NC_009614.1 Bacteroides vulgatus 4258359 4258033 NC_010655.1 Akkermansia muciniphila 2326675 2325422 NC_012781.1 Eubacterium rectale 1280802 1282049 NC_012781.1 Eubacterium rectale 783803 784687 NC_012781.1 Eubacterium rectale 2289989 2289360 NZ_AAVM02000001.1 Bacteroides caccae 205035 205766 NZ_AAVM02000001.1 Bacteroides caccae 203504 204244 NZ_AAVM02000004.1 Bacteroides caccae 19818 20552 NZ_AAVM02000004.1 Bacteroides caccae 18226 19026 NZ_AAVM02000005.1 Bacteroides caccae 117790 117089 NZ_AAVN02000002.1 Collinsella aerofaciens 214688 215971 NZ_AAVN02000005.1 Collinsella aerofaciens 3193 3990 NZ_ABJL02000008.1 Bacteroides intestinalis 2255438 2256781 NZ_ACEP01000015.1 Eubacterium hallii 5220 6134 NZ_ACEP01000037.1 Eubacterium hallii 5395 6828 NZ_ACEP01000037.1 Eubacterium hallii 6874 7077 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 568907 569809 NZ_ATFI01000010.1 Bacteroides cellulosilyticus 71257 72078 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 54384 55085 NZ_CVOY01000006.1 Bacteroides thetaiotaomicron 52086 51364 NZ_DS264518.1 Parabacteroides merdae 16658 15375 NZ_DS264540.1 Parabacteroides merdae 361593 360295 NZ_DS264579.1 Bacteroides ovatus 224414 223701 NZ_DS264583.1 Bacteroides ovatus 46086 45352 NZ_DS264583.1 Bacteroides ovatus 47678 46878 NZ_DS264584.1 Bacteroides ovatus 815730 814999 NZ_DS362241.1 Bacteroides uniformis 196137 195403 NZ_DS362241.1 Bacteroides uniformis 197729 196929 NZ_DS480690.1 Clostridium bolteae 323991 322990 NZ_DS480691.1 Clostridium bolteae 78208 77450 NZ_DS499657.1 Erysipelatoclostridium ramosum 178202 178987 NZ_DS499711.1 Clostridium scindens 60639 59893 NZ_DS499717.1 Clostridium scindens 8080 8883 NZ_DS544184.1 Anaerotruncus colihominis 122241 120328 NZ_DS544185.1 Anaerotruncus colihominis 208987 208256 NZ_DS562851.1 Clostridium spiroforme 122136 120808 NZ_DS607662.1 Providencia stuartii 136152 134944 NZ_DS607663.1 Providencia stuartii 2255207 2254365 NZ_DS981517.1 Clostridium sporogenes 2070130 2068076 NZ_DS981517.1 Clostridium sporogenes 1625390 1626655 NZ_DS990167.1 Ruminococcus lactaris 53930 53016 NZ_DS990240.1 Bifidobacterium longum 218706 219962 NZ_DS995528.1 Bacteroides dorei 147185 145257 NZ_DS995531.1 Bacteroides dorei 416684 417385 NZ_DS995533.1 Bacteroides dorei 155441 156262 NZ_DS995537.1 Bacteroides dorei 1437808 1436660 NZ_DS996451.1 Parabacteroides johnsonii 207952 208764 NZ_DS996456.1 Parabacteroides johnsonii 108659 107847 NZ_DS996456.1 Parabacteroides johnsonii 110251 109451 NZ_DS996841.1 Holdemanella biformis 530223 529429 NZ_DS996842.1 Holdemanella biformis 261013 259934 NZ_DS996921.1 Bacteroides pectinophilus 1430841 1431722 NZ_EQ973491.1 Bacteroides cellulosilyticus 1154297 1153236 NZ_EQ973628.1 Bacteroides coprophilus 87118 88245 NZ_EQ973632.1 Bacteroides coprophilus 313579 314352 NZ_GG661996.1 Proteus penneri 1167486 1168580 NZ_GG688317.1 Bacteroides finegoldii 348015 347215 NZ_GG688317.1 Bacteroides finegoldii 346423 345689 NZ_GG688319.1 Bacteroides finegoldii 253543 252737 NZ_GG688335.1 Bacteroides finegoldii 35726 34782 NZ_GG693680.1 Lactobacillus reuteri 26256 25393 NZ_GG698591.1 Blautia hansenii 55695 54289 NZ_GG703853.1 Prevotella copri 460179 461117 NZ_GG703856.1 Prevotella copri 196695 195994 NZ_GG704769.1 Subdoligranulum variabile 1915102 1914251 NZ_GG704769.1 Subdoligranulum variabile 716466 715603 NZ_GG704770.1 Subdoligranulum variabile 46083 47042 NZ_GG704863.1 Enterobacter cancerogenus 307779 308621 NZ_GG705268.1 Providencia rettgeri 11845 12723 NZ_GG729831.1 Bifidobacterium breve 488254 489387 NZ_GG739634.1 Edwardsiella tarda 126001 124481 NZ_JDUD01000001.1 Bifidobacterium breve 1961 828 NZ_JH370372.1 Alistipes indistinctus 579365 577842 NZ_JH724294.1 Bacteroides xylanisolvens 755593 756279 NZ_KB946519.1 Enterococcus faecalis 1804247 1803225 NZ_MTWC01000003.1 Clostridioides difficile 3447851 3445902 NZ_MTWF01000021.1 Clostridioides difficile 520833 518884 NZ_PPUH01000002.1 Eggerthella lenta 282952 281126 NZ_PPUH01000003.1 Eggerthella lenta 250182 248503 NZ_PUEM01000006.1 Clostridium bolteae 1494991 1494233 NZ_PUEM01000006.1 Clostridium bolteae 4993617 4992616 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1484088 1484909 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1462828 1463529 NZ_PUEP01000005.1 Bacteroides ovatus 2630015 2630746 NZ_PUEP01000005.1 Bacteroides ovatus 458680 459414 NZ_PUEP01000005.1 Bacteroides ovatus 457088 457888 NZ_PUEP01000005.1 Bacteroides ovatus 4797484 4798197 NZ_PUEQ01000002.1 Bacteroides caccae 484674 483973 NZ_PUEQ01000003.1 Bacteroides caccae 2030655 2029921 NZ_PUEQ01000003.1 Bacteroides caccae 2032247 2031447 NZ_PUEQ01000003.1 Bacteroides caccae 3827059 3827790 NZ_PUEQ01000003.1 Bacteroides caccae 3825528 3826268 NZ_UFTH01000001.1 Bacteroides fragilis 4093184 4094062 NZ_UFTH01000001.1 Bacteroides fragilis 3280562 3281596 NZ_UFTH01000001.1 Bacteroides fragilis 1493809 1494609 QEKH01000037.1 Victivallis vadensis 13374 15320 QEKH01000048.1 Victivallis vadensis 3497 2508 CVOZ01000035.1 Bacteroides thetaiotaomicron 106949 108160 CVOZ01000043.1 Bacteroides thetaiotaomicron 27888 26839 JGCP01002172.1 Bacteroides fragilis 2 874 JGCP01002354.1 Bacteroides fragilis 7402 8451 JGCP01002545.1 Bacteroides fragilis 3274 4485 NC_000913.3 Escherichia coli 425011 426039 NC_009614.1 Bacteroides vulgatus 486915 488129 NC_009614.1 Bacteroides vulgatus 1587181 1588227 NC_009615.1 Parabacteroides distasonis 4582216 4581011 NC_009615.1 Parabacteroides distasonis 2819035 2817989 NC_010655.1 Akkermansia muciniphila 843027 842053 NC_012781.1 Eubacterium rectale 1870731 1869694 NZ_AAVM02000002.1 Bacteroides caccae 264921 265970 NZ_AAVM02000003.1 Bacteroides caccae 71289 70078 NZ_AAVN02000005.1 Collinsella aerofaciens 180699 181904 NZ_AAXA02000015.1 Dorea formicigenerans 155473 154451 NZ_AAYG02000031.1 Ruminococcus gnavus 76269 75247 NZ_ABJL02000001.1 Bacteroides intestinalis 248746 247526 NZ_ABJL02000007.1 Bacteroides intestinalis 194759 193713 NZ_ABXA01000019.1 Anaerococcus hydrogenalis 158102 157086 NZ_ABXW01000004.1 Providencia alcalifaciens 121941 122987 NZ_ACCL02000019.1 Marvinbryantia formatexigens 57650 56628 NZ_ACEP01000009.1 Eubacterium hallii 16113 17132 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1098277 1099323 NZ_ATFI01000006.1 Bacteroides cellulosilyticus 233208 231988 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 140399 141610 NZ_CVOY01000046.1 Bacteroides thetaiotaomicron 28312 27263 NZ_DS264284.1 Eubacterium ventriosum 217372 216347 NZ_DS264382.1 Ruminococcus torques 70803 71837 NZ_DS264476.1 Parabacteroides merdae 37736 38782 NZ_DS264542.1 Parabacteroides merdae 311126 312331 NZ_DS264579.1 Bacteroides ovatus 416778 417827 NZ_DS264584.1 Bacteroides ovatus 16717 15506 NZ_DS362235.1 Bacteroides uniformis 56952 57998 NZ_DS362247.1 Bacteroides uniformis 304752 303532 NZ_DS480669.1 Clostridium bolteae 257651 256632 NZ_DS499656.1 Erysipelatoclostridium ramosum 69655 68633 NZ_DS499674.1 Bacteroides stercoris 260486 259440 NZ_DS499677.1 Bacteroides stercoris 230155 231375 NZ_DS499718.1 Clostridium scindens 28492 29511 NZ_DS544183.1 Anaerotruncus colihominis 144332 145372 NZ_DS562852.1 Clostridium spiroforme 49724 48702 NZ_DS607683.1 Providencia stuartii 179065 180096 NZ_DS981517.1 Clostridium sporogenes 618670 619701 NZ_DS990170.1 Ruminococcus lactaris 184161 183127 NZ_DS995508.1 Bacteroides eggerthii 169795 168575 NZ_DS995511.1 Bacteroides eggerthii 462444 461398 NZ_DS995528.1 Bacteroides dorei 148712 147498 NZ_DS995534.1 Bacteroides dorei 439390 440436 NZ_DS996452.1 Parabacteroides johnsonii 143947 142901 NZ_DS996453.1 Parabacteroides johnsonii 157487 156282 NZ_DS996921.1 Bacteroides pectinophilus 1049700 1050290 NZ_DS996921.1 Bacteroides pectinophilus 1050286 1050726 NZ_EQ973489.1 Bacteroides cellulosilyticus 174147 172927 NZ_EQ973490.1 Bacteroides cellulosilyticus 1290447 1291493 NZ_EQ973631.1 Bacteroides coprophilus 94724 93663 NZ_EQ973650.1 Bacteroides coprophilus 219067 217853 NZ_GG657592.1 Clostridium asparagiforme 3244881 3245795 NZ_GG661996.1 Proteus penneri 808745 807888 NZ_GG662010.1 Coprococcus comes 66418 65384 NZ_GG667675.1 Hungatella hathewayi 10370 9345 NZ_GG688318.1 Bacteroides finegoldii 209328 210539 NZ_GG688332.1 Bacteroides finegoldii 112379 113428 NZ_GG692710.1 Collinsella intestinalis 58740 59960 NZ_GG692730.1 Roseburia intestinalis 17297 16278 NZ_GG698588.1 Blautia hansenii 858259 857240 NZ_GG703852.1 Prevotella copri 471774 470506 NZ_GG703861.1 Prevotella copri 82450 83631 NZ_GG704769.1 Subdoligranulum variabile 943449 944462 NZ_GG704864.1 Enterobacter cancerogenus 124853 125881 NZ_GG705265.1 Providencia rettgeri 180250 179204 NZ_GG739633.1 Edwardsiella tarda 362637 363656 NZ_JGDE01000005.1 Bacteroides fragilis 6231 7280 NZ_JGDE01000133.1 Bacteroides fragilis 92211 93422 NZ_JH370371.1 Alistipes indistinctus 1466197 1467243 NZ_JH370372.1 Alistipes indistinctus 467211 466027 NZ_JH724294.1 Bacteroides xylanisolvens 201312 200101 NZ_JH724295.1 Bacteroides xylanisolvens 740942 741991 NZ_KB946519.1 Enterococcus faecalis 432320 433351 NZ_MTWC01000003.1 Clostridioides difficile 3052895 3051876 NZ_MTWD01000001.1 Clostridioides difficile 3067290 3066271 NZ_MTWE01000004.1 Clostridioides difficile 2778929 2777910 NZ_MTWF01000021.1 Clostridioides difficile 126336 125317 NZ_NSBZ01000002.1 Salmonella enterica 338306 337332 NZ_PPUH01000003.1 Eggerthella lenta 25535 26617 NZ_PUEL01000004.1 Ruminococcus gnavus 1103873 1102851 NZ_PUEM01000006.1 Clostridium bolteae 5515992 5514973 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1074907 1075956 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 699930 698719 NZ_PUEP01000005.1 Bacteroides ovatus 3429039 3430250 NZ_PUEP01000005.1 Bacteroides ovatus 4605120 4604071 NZ_PUEQ01000003.1 Bacteroides caccae 2633686 2634897 NZ_PUEQ01000003.1 Bacteroides caccae 3356989 3355940 NZ_UFTH01000001.1 Bacteroides fragilis 1051923 1053134 NZ_UFTH01000001.1 Bacteroides fragilis 2014558 2015607 QEKH01000016.1 Victivallis vadensis 92415 91372 BACDOR_03988 41 204 BT_1148 7 170 CVOZ01000016.1 Bacteroides thetaiotaomicron 104209 104940 JGCP01000803.1 Bacteroides fragilis 3204 3473 JGCP01002532.1 Bacteroides fragilis 1981 1532 JGCP01002542.1 Bacteroides fragilis 44107 43376 NC_000913.3 Escherichia coli 891196 891777 NC_008618.1 Bifidobacterium adolescentis 1983240 1983764 NC_009614.1 Bacteroides vulgatus 2241 1504 NC_009614.1 Bacteroides vulgatus 2553354 2553839 NC_009614.1 Bacteroides vulgatus 3238578 3238018 NC_009615.1 Parabacteroides distasonis 2501051 2500311 NC_009615.1 Parabacteroides distasonis 185234 184725 NC_009615.1 Parabacteroides distasonis 2044489 2044971 NZ_AAVM02000007.1 Bacteroides caccae 111194 111931 NZ_AAVN02000007.1 Collinsella aerofaciens 68266 68859 NZ_ABJL02000002.1 Bacteroides intestinalis 102975 102244 NZ_ABJL02000008.1 Bacteroides intestinalis 2984894 2985385 NZ_ACCL02000001.1 Marvinbryantia formatexigens 116314 117015 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 389871 390449 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 572171 572635 NZ_ATFI01000006.1 Bacteroides cellulosilyticus 367144 367875 NZ_CVOY01000001.1 Bacteroides thetaiotaomicron 257803 258534 NZ_DS264285.1 Eubacterium ventriosum 123016 122507 NZ_DS264518.1 Parabacteroides merdae 27196 27927 NZ_DS264580.1 Bacteroides ovatus 292879 293613 NZ_DS362242.1 Bacteroides uniformis 188956 188219 NZ_DS480690.1 Clostridium bolteae 89580 90023 NZ_DS499655.1 Erysipelatoclostridium ramosum 354524 355015 NZ_DS499676.1 Bacteroides stercoris 475435 474704 NZ_DS499697.1 Clostridium scindens 281706 282383 NZ_DS499697.1 Clostridium scindens 325343 325786 NZ_DS562853.1 Clostridium spiroforme 140563 141048 NZ_DS981517.1 Clostridium sporogenes 1671563 1672027 NZ_DS981518.1 Clostridium sporogenes 524044 524577 NZ_DS990198.1 Ruminococcus lactaris 16800 16285 NZ_DS990242.1 Bifidobacterium longum 122060 122794 NZ_DS995508.1 Bacteroides eggerthii 209488 210219 NZ_DS995531.1 Bacteroides dorei 345468 346205 NZ_DS995536.1 Bacteroides dorei 38613 38128 NZ_DS995537.1 Bacteroides dorei 674814 674254 NZ_DS996446.1 Parabacteroides johnsonii 59128 59640 NZ_DS996456.1 Parabacteroides johnsonii 45966 45229 NZ_DS996844.1 Holdemanella biformis 9201 9803 NZ_DS996847.1 Holdemanella biformis 35961 36455 NZ_EQ973489.1 Bacteroides cellulosilyticus 369930 370583 NZ_EQ973491.1 Bacteroides cellulosilyticus 190366 189788 NZ_EQ973651.1 Bacteroides coprophilus 153905 154642 NZ_GG657595.1 Clostridium asparagiforme 13750 13313 NZ_GG662012.1 Coprococcus comes 43441 42917 NZ_GG688321.1 Bacteroides finegoldii 291692 290958 NZ_GG688334.1 Bacteroides finegoldii 50704 51141 NZ_GG692710.1 Collinsella intestinalis 1194654 1194136 NZ_GG692723.1 Roseburia intestinalis 45135 44680 NZ_GG693679.1 Lactobacillus reuteri 97 633 NZ_GG698590.1 Blautia hansenii 424867 424271 NZ_GG703854.1 Prevotella copri 357269 358000 NZ_GG704774.1 Subdoligranulum variabile 1827 2453 NZ_GG704863.1 Enterobacter cancerogenus 397917 398492 NZ_GG729831.1 Bifidobacterium breve 6677 5940 NZ_GG739633.1 Edwardsiella tarda 1759109 1758594 NZ_JGDE01000133.1 Bacteroides fragilis 56983 56252 NZ_JH370371.1 Alistipes indistinctus 1207458 1206736 NZ_JH370372.1 Alistipes indistinctus 265973 265428 NZ_JH724296.1 Bacteroides xylanisolvens 301016 300282 NZ_KB946519.1 Enterococcus faecalis 784642 784046 NZ_KE136402.1 Enterococcus faecalis 2316901 2317497 NZ_MTWC01000003.1 Clostridioides difficile 183069 182566 NZ_MTWD01000001.1 Clostridioides difficile 272104 271601 NZ_PUEL01000004.1 Ruminococcus gnavus 423569 423006 NZ_PUEM01000006.1 Clostridium bolteae 4759212 4759655 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 338541 339272 NZ_PUEP01000005.1 Bacteroides ovatus 562285 561656 NZ_PUEP01000015.1 Bacteroides ovatus 146479 147213 NZ_PUEQ01000003.1 Bacteroides caccae 349059 349796 NZ_UFTH01000001.1 Bacteroides fragilis 1012777 1012046 NZ_UFTH01000001.1 Bacteroides fragilis 627434 626985 QEKH01000020.1 Victivallis vadensis 35006 35443 BT_0569 32 234 BT_4075 37 107 BT_4096 1 225 CVOZ01000053.1 Bacteroides thetaiotaomicron 57242 56634 JGCP01000996.1 Bacteroides fragilis 438 7 JGCP01001374.1 Bacteroides fragilis 8889 9464 JGCP01002361.1 Bacteroides fragilis 711 136 JGCP01002366.1 Bacteroides fragilis 7394 6798 JGCP01002441.1 Bacteroides fragilis 9814 10422 JGCP01002459.1 Bacteroides fragilis 103650 103045 JGCP01002552.1 Bacteroides fragilis 31137 31757 NC_009614.1 Bacteroides vulgatus 5100333 5099671 NC_009615.1 Parabacteroides distasonis 1135108 1135623 NC_010655.1 Akkermansia muciniphila 28365 28967 NZ_AAVM02000001.1 Bacteroides caccae 1240830 1240231 NZ_AAVM02000003.1 Bacteroides caccae 380349 379744 NZ_AAYG02000020.1 Ruminococcus gnavus 146583 146029 NZ_ABJL02000006.1 Bacteroides intestinalis 363926 364525 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 142507 143106 NZ_CVOY01000005.1 Bacteroides thetaiotaomicron 209440 210048 NZ_DS264582.1 Bacteroides ovatus 46715 46128 NZ_DS362220.1 Bacteroides uniformis 323248 322721 NZ_DS362220.1 Bacteroides uniformis 17094 16558 NZ_DS362233.1 Bacteroides uniformis 68137 68724 NZ_DS362246.1 Bacteroides uniformis 117769 117260 NZ_DS480679.1 Clostridium bolteae 119727 120254 NZ_DS499674.1 Bacteroides stercoris 577837 577238 NZ_DS562848.1 Clostridium spiroforme 372214 372744 NZ_DS995510.1 Bacteroides eggerthii 656723 657343 NZ_DS995511.1 Bacteroides eggerthii 728361 727798 NZ_DS995531.1 Bacteroides dorei 447813 448475 NZ_DS996921.1 Bacteroides pectinophilus 466835 467326 NZ_EQ973490.1 Bacteroides cellulosilyticus 257404 258003 NZ_EQ973490.1 Bacteroides cellulosilyticus 916552 917088 NZ_GG657592.1 Clostridium asparagiforme 3235183 3234566 NZ_GG688322.1 Bacteroides finegoldii 129579 130202 NZ_GG692731.1 Roseburia intestinalis 64242 63706 NZ_GG704769.1 Subdoligranulum variabile 1963367 1962822 NZ_JGDE01000016.1 Bacteroides fragilis 30454 29879 NZ_JGDE01000017.1 Bacteroides fragilis 7455 6859 NZ_JGDE01000072.1 Bacteroides fragilis 9293 9901 NZ_JGDE01000091.1 Bacteroides fragilis 22097 21492 NZ_JGDE01000136.1 Bacteroides fragilis 27267 27887 NZ_JH370372.1 Alistipes indistinctus 98423 97824 NZ_JH724294.1 Bacteroides xylanisolvens 2429518 2428898 NZ_PUEL01000004.1 Ruminococcus gnavus 1632318 1631764 NZ_PUEM01000006.1 Clostridium bolteae 5989960 5990487 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2506964 2507572 NZ_PUEP01000005.1 Bacteroides ovatus 917658 918245 NZ_PUEQ01000003.1 Bacteroides caccae 1529639 1529040 NZ_PUEQ01000003.1 Bacteroides caccae 2324622 2325227 NZ_UFTH01000001.1 Bacteroides fragilis 4050588 4051196 NZ_UFTH01000001.1 Bacteroides fragilis 2389564 2388968 NZ_UFTH01000001.1 Bacteroides fragilis 1188676 1189296 NZ_UFTH01000001.1 Bacteroides fragilis 4569605 4569000 NZ_UFTH01000001.1 Bacteroides fragilis 2353159 2352584 NZ_UFTH01000005.1 Bacteroides fragilis 8645 9220 QEKH01000033.1 Victivallis vadensis 30085 29582 NZ_CVOY01000074.1 Bacteroides thetaiotaomicron 35629 37335 NZ_DS544177.1 Anaerotruncus colihominis 189303 188698 NZ_DS995508.1 Bacteroides eggerthii 515682 513877 NZ_DS995532.1 Bacteroides dorei 23809 25614 NZ_EQ973637.1 Bacteroides coprophilus 53028 51301 NZ_EQ973637.1 Bacteroides coprophilus 245618 243906 NZ_EQ973651.1 Bacteroides coprophilus 5698 4001 NZ_UFTH01000001.1 Bacteroides fragilis 4306248 4304464 CVOZ01000037.1 Bacteroides thetaiotaomicron 13492 12218 JGCP01002370.1 Bacteroides fragilis 62642 63922 NC_009614.1 Bacteroides vulgatus 1946317 1945031 NC_009615.1 Parabacteroides distasonis 3695035 3696270 NZ_ABJL02000007.1 Bacteroides intestinalis 1302828 1301614 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 489104 490372 NZ_CVOY01000020.1 Bacteroides thetaiotaomicron 109540 110814 NZ_DS264542.1 Parabacteroides merdae 110435 109170 NZ_DS362243.1 Bacteroides uniformis 74012 72777 NZ_DS499676.1 Bacteroides stercoris 78183 79397 NZ_DS995534.1 Bacteroides dorei 879429 878143 NZ_DS996444.1 Parabacteroides johnsonii 721304 720039 NZ_EQ973492.1 Bacteroides cellulosilyticus 1012038 1013306 NZ_JGDE01000020.1 Bacteroides fragilis 8680 9897 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 20242 18968 NZ_UFTH01000001.1 Bacteroides fragilis 2558717 2559997 BT_2068 1 253 CVOZ01000016.1 Bacteroides thetaiotaomicron 213809 214567 JGCP01001391.1 Bacteroides fragilis 1827 1213 JGCP01002541.1 Bacteroides fragilis 59029 58271 NC_009614.1 Bacteroides vulgatus 2545071 2545832 NZ_AAVM02000007.1 Bacteroides caccae 240333 241091 NZ_ABJL02000002.1 Bacteroides intestinalis 14878 14120 NZ_ATFI01000018.1 Bacteroides cellulosilyticus 73581 72838 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 107627 108385 NZ_DS264546.1 Parabacteroides merdae 161605 162363 NZ_DS264580.1 Bacteroides ovatus 422161 422919 NZ_DS362242.1 Bacteroides uniformis 128891 128124 NZ_DS499676.1 Bacteroides stercoris 354507 353740 NZ_DS995508.1 Bacteroides eggerthii 374349 375116 NZ_DS995536.1 Bacteroides dorei 46897 46136 NZ_DS996453.1 Parabacteroides johnsonii 310455 311213 NZ_EQ973489.1 Bacteroides cellulosilyticus 471401 472159 NZ_EQ973643.1 Bacteroides coprophilus 27626 28387 NZ_GG688318.1 Bacteroides finegoldii 85948 85178 NZ_GG688321.1 Bacteroides finegoldii 185788 185030 NZ_JGDE01000131.1 Bacteroides fragilis 10637 9879 NZ_JH370372.1 Alistipes indistinctus 247945 248700 NZ_JH724296.1 Bacteroides xylanisolvens 113928 113170 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 447878 448636 NZ_PUEP01000015.1 Bacteroides ovatus 275761 276519 NZ_PUEQ01000003.1 Bacteroides caccae 478198 478956 NZ_UFTH01000001.1 Bacteroides fragilis 906258 905500 NZ_DS995536.1 Bacteroides dorei 48870 47308 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 751938 753500 BT_2961 1 285 BT_4075 177 235 BT_4096 158 231 COLAER_00815 96 240 CVOZ01000004.1 Bacteroides thetaiotaomicron 1448 2302 CVOZ01000011.1 Bacteroides thetaiotaomicron 76261 77025 JGCP01002268.1 Bacteroides fragilis 1309 668 NC_009614.1 Bacteroides vulgatus 2618474 2619322 NZ_AAVM02000002.1 Bacteroides caccae 22009 21158 NZ_CVOY01000037.1 Bacteroides thetaiotaomicron 89304 90158 NZ_DS264554.1 Bacteroides ovatus 556078 555293 NZ_DS995537.1 Bacteroides dorei 24054 24902 NZ_DS996456.1 Parabacteroides johnsonii 449203 448439 NZ_JH724295.1 Bacteroides xylanisolvens 331780 330995 NZ_JH724300.1 Bacteroides xylanisolvens 14631 13909 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 699564 698710 NZ_PUEP01000005.1 Bacteroides ovatus 5040250 5041035 NZ_PUEQ01000003.1 Bacteroides caccae 3599902 3600753 CVOZ01000032.1 Bacteroides thetaiotaomicron 278437 277562 CVOZ01000032.1 Bacteroides thetaiotaomicron 327847 326954 CVOZ01000032.1 Bacteroides thetaiotaomicron 335851 336507 CVOZ01000032.1 Bacteroides thetaiotaomicron 289144 289842 CVOZ01000032.1 Bacteroides thetaiotaomicron 289870 290580 CVOZ01000033.1 Bacteroides thetaiotaomicron 38815 37955 JGCP01000713.1 Bacteroides fragilis 233 931 JGCP01000713.1 Bacteroides fragilis 959 1468 JGCP01001256.1 Bacteroides fragilis 1150 194 JGCP01001408.1 Bacteroides fragilis 564 1220 NC_009614.1 Bacteroides vulgatus 2779799 2781439 NC_009614.1 Bacteroides vulgatus 2620046 2620657 NC_009614.1 Bacteroides vulgatus 2619532 2620038 NC_009614.1 Bacteroides vulgatus 2352196 2353167 NC_009614.1 Bacteroides vulgatus 2620668 2621141 NC_009614.1 Bacteroides vulgatus 288953 289606 NC_009614.1 Bacteroides vulgatus 244590 243868 NC_009614.1 Bacteroides vulgatus 245316 244618 NC_009614.1 Bacteroides vulgatus 2620777 2620842 NC_009614.1 Bacteroides vulgatus 2620841 2620945 NZ_AAVM02000003.1 Bacteroides caccae 187381 188355 NZ_AAYG02000020.1 Ruminococcus gnavus 156048 155356 NZ_ABJL02000002.1 Bacteroides intestinalis 153696 152815 NZ_ABJL02000002.1 Bacteroides intestinalis 242190 241192 NZ_ABJL02000008.1 Bacteroides intestinalis 2826397 2825381 NZ_ABJL02000008.1 Bacteroides intestinalis 2603612 2602923 NZ_ABJL02000008.1 Bacteroides intestinalis 3206175 3206885 NZ_ABJL02000008.1 Bacteroides intestinalis 3205449 3206435 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 193354 192338 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 698860 699570 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 698128 699120 NZ_ATFI01000006.1 Bacteroides cellulosilyticus 337473 338303 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 425892 425203 NZ_CVOY01000002.1 Bacteroides thetaiotaomicron 10928 11803 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 33471 34445 NZ_CVOY01000030.1 Bacteroides thetaiotaomicron 60870 61763 NZ_CVOY01000030.1 Bacteroides thetaiotaomicron 51365 50709 NZ_CVOY01000108.1 Bacteroides thetaiotaomicron 179 877 NZ_CVOY01000108.1 Bacteroides thetaiotaomicron 905 1615 NZ_DS264554.1 Bacteroides ovatus 198660 199562 NZ_DS264554.1 Bacteroides ovatus 197946 198665 NZ_DS264579.1 Bacteroides ovatus 101730 101050 NZ_DS264579.1 Bacteroides ovatus 102462 101758 NZ_DS264584.1 Bacteroides ovatus 301586 302560 NZ_DS264584.1 Bacteroides ovatus 428271 429146 NZ_DS264584.1 Bacteroides ovatus 377614 376958 NZ_DS264584.1 Bacteroides ovatus 434485 435183 NZ_DS264584.1 Bacteroides ovatus 417597 416878 NZ_DS264584.1 Bacteroides ovatus 418350 417574 NZ_DS362249.1 Bacteroides uniformis 289634 288054 NZ_DS499676.1 Bacteroides stercoris 561250 560255 NZ_DS981517.1 Clostridium sporogenes 457008 457370 NZ_DS990171.1 Ruminococcus lactaris 5187 5534 NZ_DS995509.1 Bacteroides eggerthii 327513 328508 NZ_DS995531.1 Bacteroides dorei 93535 94410 NZ_DS995531.1 Bacteroides dorei 50130 49477 NZ_DS995531.1 Bacteroides dorei 106361 107083 NZ_DS995531.1 Bacteroides dorei 105635 106333 NZ_DS995536.1 Bacteroides dorei 242505 241396 NZ_DS995537.1 Bacteroides dorei 25114 27072 NZ_DS995537.1 Bacteroides dorei 1373127 1374776 NZ_DS996921.1 Bacteroides pectinophilus 1405526 1406158 NZ_EQ973486.1 Bacteroides cellulosilyticus 92459 91749 NZ_EQ973486.1 Bacteroides cellulosilyticus 93191 92199 NZ_EQ973489.1 Bacteroides cellulosilyticus 322372 323022 NZ_EQ973491.1 Bacteroides cellulosilyticus 393142 394158 NZ_EQ973491.1 Bacteroides cellulosilyticus 671842 672531 NZ_EQ973492.1 Bacteroides cellulosilyticus 492581 491853 NZ_GG688320.1 Bacteroides finegoldii 264894 263914 NZ_GG688320.1 Bacteroides finegoldii 202708 203607 NZ_GG688320.1 Bacteroides finegoldii 231551 232207 NZ_GG688320.1 Bacteroides finegoldii 195186 194512 NZ_GG688320.1 Bacteroides finegoldii 209971 210669 NZ_GG688320.1 Bacteroides finegoldii 210700 211410 NZ_GG692716.1 Roseburia intestinalis 57615 58253 NZ_GG703858.1 Prevotella copri 109675 108758 NZ_JH370372.1 Alistipes indistinctus 102822 102526 NZ_JH724294.1 Bacteroides xylanisolvens 390497 391471 NZ_PUEL01000004.1 Ruminococcus gnavus 1641783 1641091 NZ_PUEL01000004.1 Ruminococcus gnavus 2394471 2394827 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 899572 900546 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1031435 1032310 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 982003 982896 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 973993 973337 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1020728 1020030 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1020002 1019292 NZ_PUEP01000005.1 Bacteroides ovatus 3144163 3143189 NZ_PUEP01000005.1 Bacteroides ovatus 5398858 5397956 NZ_PUEP01000005.1 Bacteroides ovatus 3017478 3016603 NZ_PUEP01000005.1 Bacteroides ovatus 5399572 5398853 NZ_PUEP01000005.1 Bacteroides ovatus 3068135 3068791 NZ_PUEP01000005.1 Bacteroides ovatus 3011264 3010566 NZ_PUEP01000005.1 Bacteroides ovatus 3028152 3028871 NZ_PUEP01000005.1 Bacteroides ovatus 3027399 3028175 NZ_PUEP01000005.1 Bacteroides ovatus 4920170 4920850 NZ_PUEP01000005.1 Bacteroides ovatus 4919438 4920142 NZ_PUEQ01000003.1 Bacteroides caccae 2517594 2516620 QEKH01000014.1 Victivallis vadensis 69266 69907 BT_1192 363 462 BT_3124 260 347 COLAER_00815 69 229 CVOZ01000032.1 Bacteroides thetaiotaomicron 320584 319970 CVOZ01000032.1 Bacteroides thetaiotaomicron 279286 278453 NC_009614.1 Bacteroides vulgatus 3010156 3011628 NZ_ABJL02000002.1 Bacteroides intestinalis 241062 240220 NZ_ABJL02000008.1 Bacteroides intestinalis 2609905 2610504 NZ_CVOY01000002.1 Bacteroides thetaiotaomicron 10079 10912 NZ_CVOY01000030.1 Bacteroides thetaiotaomicron 76891 77505 NZ_DS264584.1 Bacteroides ovatus 442833 441991 NZ_DS995537.1 Bacteroides dorei 355341 356813 NZ_DS996921.1 Bacteroides pectinophilus 215285 215857 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 989267 989881 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1030586 1031419 NZ_PUEP01000005.1 Bacteroides ovatus 3002916 3003758 CVOZ01000025.1 Bacteroides thetaiotaomicron 228497 228021 JGCP01002418.1 Bacteroides fragilis 53739 53263 NC_009614.1 Bacteroides vulgatus 3013253 3012750 NC_009615.1 Parabacteroides distasonis 2483154 2482669 NC_012781.1 Eubacterium rectale 275468 275845 NZ_AAVM02000006.1 Bacteroides caccae 294260 293784 NZ_AAXA02000015.1 Dorea formicigenerans 81674 81237 NZ_AAYG02000020.1 Ruminococcus gnavus 14089 13706 NZ_ABJL02000008.1 Bacteroides intestinalis 1575489 1575968 NZ_ABXA01000014.1 Anaerococcus hydrogenalis 10995 11324 NZ_ACCL02000004.1 Marvinbryantia formatexigens 228462 228866 NZ_ATFI01000017.1 Bacteroides cellulosilyticus 48893 49372 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 68589 68113 NZ_DS264284.1 Eubacterium ventriosum 34205 33930 NZ_DS264346.1 Ruminococcus torques 54583 54975 NZ_DS264518.1 Parabacteroides merdae 43023 43499 NZ_DS264583.1 Bacteroides ovatus 165036 165512 NZ_DS362249.1 Bacteroides uniformis 38171 38653 NZ_DS480678.1 Clostridium bolteae 117255 116866 NZ_DS499655.1 Erysipelatoclostridium ramosum 390371 390754 NZ_DS499671.1 Bacteroides stercoris 73424 73900 NZ_DS499697.1 Clostridium scindens 310825 310430 NZ_DS544181.1 Anaerotruncus colihominis 168009 167620 NZ_DS562853.1 Clostridium spiroforme 159590 159871 NZ_DS981517.1 Clostridium sporogenes 734347 734709 NZ_DS990204.1 Ruminococcus lactaris 1040 633 NZ_DS995509.1 Bacteroides eggerthii 1263753 1263277 NZ_DS995537.1 Bacteroides dorei 357809 357306 NZ_DS996456.1 Parabacteroides johnsonii 29766 29311 NZ_DS996922.1 Bacteroides pectinophilus 5548 5931 NZ_EQ973488.1 Bacteroides cellulosilyticus 349840 350319 NZ_EQ973651.1 Bacteroides coprophilus 150422 149964 NZ_GG657592.1 Clostridium asparagiforme 1177311 1177730 NZ_GG667608.1 Hungatella hathewayi 147420 147797 NZ_GG688318.1 Bacteroides finegoldii 355312 354836 NZ_GG692711.1 Collinsella intestinalis 96648 97034 NZ_GG692730.1 Roseburia intestinalis 30330 29962 NZ_GG698588.1 Blautia hansenii 167573 167190 NZ_GG703872.1 Prevotella copri 670 194 NZ_GG704769.1 Subdoligranulum variabile 1484289 1483900 NZ_JGDE01000051.1 Bacteroides fragilis 16766 16290 NZ_JH370372.1 Alistipes indistinctus 1077514 1077068 NZ_JH724297.1 Bacteroides xylanisolvens 316915 317391 NZ_KE136402.1 Enterococcus faecalis 75167 74802 NZ_MTWC01000003.1 Clostridioides difficile 2570171 2569785 NZ_MTWD01000001.1 Clostridioides difficile 2608785 2608399 NZ_MTWE01000004.1 Clostridioides difficile 2328222 2327836 NZ_PUEL01000004.1 Ruminococcus gnavus 1499825 1499442 NZ_PUEM01000006.1 Clostridium bolteae 4150728 4151117 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3701254 3701730 NZ_PUEP01000005.1 Bacteroides ovatus 339730 339254 NZ_PUEQ01000002.1 Bacteroides caccae 341319 340843 NZ_UFTH01000001.1 Bacteroides fragilis 3641424 3640948 CVOZ01000042.1 Bacteroides thetaiotaomicron 34688 34368 JGCP01002359.1 Bacteroides fragilis 41007 41324 NC_000913.3 Escherichia coli 904593 904904 NC_009614.1 Bacteroides vulgatus 3013445 3013765 NC_009615.1 Parabacteroides distasonis 3249031 3249348 NZ_AAVM02000009.1 Bacteroides caccae 17283 17603 NZ_ABJL02000007.1 Bacteroides intestinalis 704388 704705 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 421004 420687 NZ_CVOY01000010.1 Bacteroides thetaiotaomicron 7919 7599 NZ_DS264359.1 Ruminococcus torques 17253 17570 NZ_DS264364.1 Ruminococcus torques 42135 42452 NZ_DS264544.1 Parabacteroides merdae 742 425 NZ_DS362223.1 Bacteroides uniformis 11655 11972 NZ_DS362246.1 Bacteroides uniformis 3066 3389 NZ_DS499674.1 Bacteroides stercoris 462363 462680 NZ_DS544185.1 Anaerotruncus colihominis 14445 14128 NZ_DS562844.1 Clostridium spiroforme 291249 291566 NZ_DS981517.1 Clostridium sporogenes 935496 935179 NZ_DS990238.1 Bifidobacterium longum 668976 668662 NZ_DS995511.1 Bacteroides eggerthii 638934 639251 NZ_DS995537.1 Bacteroides dorei 358000 358320 NZ_DS996456.1 Parabacteroides johnsonii 1015093 1015410 NZ_EQ973490.1 Bacteroides cellulosilyticus 533321 533004 NZ_EQ973647.1 Bacteroides coprophilus 14447 14764 NZ_GG692710.1 Collinsella intestinalis 1023607 1023903 NZ_GG703853.1 Prevotella copri 386355 386041 NZ_GG704863.1 Enterobacter cancerogenus 413348 413659 NZ_GG729830.1 Bifidobacterium breve 191349 191663 NZ_JGDE01000013.1 Bacteroides fragilis 22693 23010 NZ_JH724295.1 Bacteroides xylanisolvens 1124087 1124407 NZ_MTWC01000003.1 Clostridioides difficile 1788196 1788510 NZ_MTWD01000001.1 Clostridioides difficile 1830939 1831253 NZ_MTWE01000004.1 Clostridioides difficile 1523761 1524075 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1360437 1360757 NZ_PUEQ01000003.1 Bacteroides caccae 3090859 3090539 NZ_UFTH01000001.1 Bacteroides fragilis 2193266 2193583 BACDOR_03648 2 191 CVOZ01000037.1 Bacteroides thetaiotaomicron 90333 89671 CVOZ01000037.1 Bacteroides thetaiotaomicron 90656 90387 JGCP01002370.1 Bacteroides fragilis 19946 20590 JGCP01002370.1 Bacteroides fragilis 19647 19904 NC_009614.1 Bacteroides vulgatus 3014449 3013841 NC_009614.1 Bacteroides vulgatus 3015154 3014498 NZ_AAVM02000001.1 Bacteroides caccae 401183 401740 NZ_AAVM02000001.1 Bacteroides caccae 400813 401082 NZ_ABJL02000008.1 Bacteroides intestinalis 189847 189212 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 182016 182639 NZ_CVOY01000020.1 Bacteroides thetaiotaomicron 75232 75894 NZ_CVOY01000020.1 Bacteroides thetaiotaomicron 74909 75178 NZ_DS264554.1 Bacteroides ovatus 96010 95354 NZ_DS264554.1 Bacteroides ovatus 96327 96058 NZ_DS362237.1 Bacteroides uniformis 68919 68383 NZ_DS995537.1 Bacteroides dorei 359004 358396 NZ_DS995537.1 Bacteroides dorei 359709 359053 NZ_EQ973492.1 Bacteroides cellulosilyticus 702548 703171 NZ_GG703853.1 Prevotella copri 10442 9792 NZ_JGDE01000019.1 Bacteroides fragilis 85207 85851 NZ_JGDE01000019.1 Bacteroides fragilis 84908 85165 NZ_JH724299.1 Bacteroides xylanisolvens 71964 72233 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 97086 96424 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 97409 97140 NZ_PUEP01000005.1 Bacteroides ovatus 5502584 5503240 NZ_PUEP01000005.1 Bacteroides ovatus 5502267 5502536 NZ_PUEQ01000003.1 Bacteroides caccae 74218 74775 NZ_PUEQ01000003.1 Bacteroides caccae 73848 74117 NZ_UFTH01000001.1 Bacteroides fragilis 2516016 2516660 NZ_UFTH01000001.1 Bacteroides fragilis 2515717 2515974 BACDOR_03647 31 202 CVOZ01000037.1 Bacteroides thetaiotaomicron 90246 89671 JGCP01002370.1 Bacteroides fragilis 20039 20590 NC_009614.1 Bacteroides vulgatus 3015070 3014486 NC_009614.1 Bacteroides vulgatus 3014359 3013844 NZ_AAVM02000001.1 Bacteroides caccae 401216 401779 NZ_AAVM02000001.1 Bacteroides caccae 400750 401082 NZ_ABJL02000008.1 Bacteroides intestinalis 189775 189191 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 182088 182639 NZ_CVOY01000020.1 Bacteroides thetaiotaomicron 75319 75894 NZ_DS264554.1 Bacteroides ovatus 95923 95354 NZ_DS264554.1 Bacteroides ovatus 96381 96097 NZ_DS362237.1 Bacteroides uniformis 68919 68383 NZ_DS995537.1 Bacteroides dorei 359625 359041 NZ_DS995537.1 Bacteroides dorei 358914 358399 NZ_EQ973492.1 Bacteroides cellulosilyticus 702620 703171 NZ_GG688330.1 Bacteroides finegoldii 122724 123047 NZ_GG703853.1 Prevotella copri 10352 9831 NZ_JGDE01000019.1 Bacteroides fragilis 85300 85851 NZ_JH724299.1 Bacteroides xylanisolvens 71928 72194 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 96999 96424 NZ_PUEP01000005.1 Bacteroides ovatus 5502671 5503240 NZ_PUEP01000005.1 Bacteroides ovatus 5502213 5502497 NZ_PUEQ01000003.1 Bacteroides caccae 74251 74814 NZ_PUEQ01000003.1 Bacteroides caccae 73785 74117 NZ_UFTH01000001.1 Bacteroides fragilis 2516109 2516660 BT_2367 1 382 CVOZ01000011.1 Bacteroides thetaiotaomicron 219307 218162 CVOZ01000025.1 Bacteroides thetaiotaomicron 65956 64922 JGCP01000352.1 Bacteroides fragilis 1001 3 JGCP01002360.1 Bacteroides fragilis 22362 21214 NC_009614.1 Bacteroides vulgatus 3184401 3185549 NC_009615.1 Parabacteroides distasonis 4010282 4011415 NC_010655.1 Akkermansia muciniphila 2181545 2180451 NC_010655.1 Akkermansia muciniphila 910779 911906 NZ_AAVM02000006.1 Bacteroides caccae 286961 285936 NZ_AAVM02000010.1 Bacteroides caccae 85750 86895 NZ_ABJL02000007.1 Bacteroides intestinalis 1352596 1353708 NZ_ABJL02000008.1 Bacteroides intestinalis 11440 12579 NZ_ACEP01000056.1 Eubacterium hallii 19442 19756 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 320605 319457 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 180818 179655 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 433197 432085 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 454543 453536 NZ_CVOY01000001.1 Bacteroides thetaiotaomicron 78559 77414 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 61418 60384 NZ_DS264546.1 Parabacteroides merdae 79517 80632 NZ_DS264553.1 Bacteroides ovatus 176886 178034 NZ_DS264583.1 Bacteroides ovatus 172699 173733 NZ_DS362220.1 Bacteroides uniformis 32930 34078 NZ_DS362243.1 Bacteroides uniformis 130985 132106 NZ_DS499676.1 Bacteroides stercoris 625044 623935 NZ_DS499676.1 Bacteroides stercoris 38390 37269 NZ_DS995510.1 Bacteroides eggerthii 1115618 1114497 NZ_DS995537.1 Bacteroides dorei 622799 623947 NZ_DS996453.1 Parabacteroides johnsonii 228018 229163 NZ_DS996453.1 Parabacteroides johnsonii 441885 442970 NZ_EQ973492.1 Bacteroides cellulosilyticus 841963 840815 NZ_EQ973492.1 Bacteroides cellulosilyticus 701350 700187 NZ_EQ973495.1 Bacteroides cellulosilyticus 221652 222659 NZ_EQ973543.1 Bacteroides cellulosilyticus 701 3 NZ_EQ973643.1 Bacteroides coprophilus 523657 524796 NZ_GG688326.1 Bacteroides finegoldii 160819 161967 NZ_JH370372.1 Alistipes indistinctus 793551 792436 NZ_JH724294.1 Bacteroides xylanisolvens 2266288 2265140 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 85095 83950 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3708426 3709460 NZ_PUEP01000005.1 Bacteroides ovatus 1142186 1143334 NZ_PUEP01000005.1 Bacteroides ovatus 332067 331033 NZ_PUEQ01000002.1 Bacteroides caccae 334020 332995 NZ_PUEQ01000003.1 Bacteroides caccae 2119148 2118003 NZ_UFTH01000001.1 Bacteroides fragilis 2311470 2310322 BT_0152 21 272 COLAER_01894 110 150 CVOZ01000033.1 Bacteroides thetaiotaomicron 95414 94584 CVOZ01000058.1 Bacteroides thetaiotaomicron 56650 57405 JGCP01002414.1 Bacteroides fragilis 51703 52458 NC_000913.3 Escherichia coli 3900190 3899414 NC_009614.1 Bacteroides vulgatus 3187980 3188795 NC_009615.1 Parabacteroides distasonis 3801163 3801933 NC_009615.1 Parabacteroides distasonis 2376805 2377557 NZ_AAVM02000004.1 Bacteroides caccae 216505 217236 NZ_ABJL02000007.1 Bacteroides intestinalis 250198 250920 NZ_ABJL02000008.1 Bacteroides intestinalis 1128333 1127566 NZ_ABJL02000008.1 Bacteroides intestinalis 2507036 2506242 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 437624 437184 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 397686 398429 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 325780 324986 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 23231 22401 NZ_CVOY01000040.1 Bacteroides thetaiotaomicron 78733 78002 NZ_DS264541.1 Parabacteroides merdae 313243 313983 NZ_DS264541.1 Parabacteroides merdae 27216 26359 NZ_DS264554.1 Bacteroides ovatus 368631 369470 NZ_DS264554.1 Bacteroides ovatus 367127 367921 NZ_DS362233.1 Bacteroides uniformis 74461 73730 NZ_DS362239.1 Bacteroides uniformis 7728 6928 NZ_DS362239.1 Bacteroides uniformis 5156 4731 NZ_DS362240.1 Bacteroides uniformis 212934 213686 NZ_DS499653.1 Erysipelatoclostridium ramosum 194977 194246 NZ_DS499673.1 Bacteroides stercoris 206561 207376 NZ_DS607663.1 Providencia stuartii 1086310 1087089 NZ_DS995510.1 Bacteroides eggerthii 209097 209912 NZ_DS995537.1 Bacteroides dorei 626379 627194 NZ_DS995537.1 Bacteroides dorei 1307678 1306917 NZ_DS996440.1 Parabacteroides johnsonii 32520 31849 NZ_DS996532.1 Parabacteroides johnsonii 838 98 NZ_DS996921.1 Bacteroides pectinophilus 1565854 1566558 NZ_EQ973490.1 Bacteroides cellulosilyticus 1229269 1228547 NZ_EO973490.1 Bacteroides cellulosilyticus 549879 549439 NZ_EQ973491.1 Bacteroides cellulosilyticus 776889 777764 NZ_EQ973495.1 Bacteroides cellulosilyticus 279325 278582 NZ_EQ973651.1 Bacteroides coprophilus 37033 36287 NZ_GG667608.1 Hungatella hathewayi 95800 95153 NZ_GG667608.1 Hungatella hathewayi 94944 94324 NZ_GG688325.1 Bacteroides finegoldii 120247 120978 NZ_GG704769.1 Subdoligranulum variabile 177713 178351 NZ_GG705264.1 Providencia rettgeri 106827 106045 NZ_JGDE01000048.1 Bacteroides fragilis 11590 12345 NZ_JH370371.1 Alistipes indistinctus 55343 54528 NZ_JH370371.1 Alistipes indistinctus 53836 52994 NZ_JH724294.1 Bacteroides xylanisolvens 1276334 1277065 NZ_KB946519.1 Enterococcus faecalis 364107 364835 NZ_MTWC01000003.1 Clostridioides difficile 2304297 2303677 NZ_MTWD01000001.1 Clostridioides difficile 2346475 2345855 NZ_MTWE01000004.1 Clostridioides difficile 2075454 2074834 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1959081 1959812 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 843093 843923 NZ_PUEP01000005.1 Bacteroides ovatus 2224557 2223826 NZ_PUEP01000005.1 Bacteroides ovatus 5227698 5226859 NZ_PUEP01000005.1 Bacteroides ovatus 5229202 5228408 NZ_PUEQ01000003.1 Bacteroides caccae 1833970 1833239 NZ_UFTH01000001.1 Bacteroides fragilis 3547965 3548720 NZ_UFTH01000001.1 Bacteroides fragilis 1289092 1288223 QEKH01000010.1 Victivallis vadensis 10295 9546 BACDOR_00571 1 175 BT_0217 24 198 BT_1006 10 78 BT_1148 4 168 COLAER_01707 4 116 CVOZ01000022.1 Bacteroides thetaiotaomicron 96972 97520 CVOZ01000044.1 Bacteroides thetaiotaomicron 270175 270669 CVOZ01000058.1 Bacteroides thetaiotaomicron 90345 90884 CVOZ01000063.1 Bacteroides thetaiotaomicron 213261 213785 JGCP01001429.1 Bacteroides fragilis 413 3 JGCP01002513.1 Bacteroides fragilis 8425 7883 JGCP01002532.1 Bacteroides fragilis 1963 1505 NC_000913.3 Escherichia coli 891154 891663 NC_009614.1 Bacteroides vulgatus 3238698 3238072 NC_009614.1 Bacteroides vulgatus 2553354 2553818 NC_009614.1 Bacteroides vulgatus 3195978 3196472 NC_009614.1 Bacteroides vulgatus 1289396 1288881 NC_009615.1 Parabacteroides distasonis 2044441 2044980 NC_009615.1 Parabacteroides distasonis 185216 184800 NC_009615.1 Parabacteroides distasonis 178476 179009 NZ_AAVM02000001.1 Bacteroides caccae 1119730 1119206 NZ_AAVM02000004.1 Bacteroides caccae 244889 245428 NZ_AAVM02000005.1 Bacteroides caccae 238680 239204 NZ_AAVM02000006.1 Bacteroides caccae 117389 117928 NZ_AAXA02000015.1 Dorea formicigenerans 812473 812982 NZ_AAXA02000015.1 Dorea formicigenerans 428131 428625 NZ_ABJL02000007.1 Bacteroides intestinalis 959684 959124 NZ_ABJL02000008.1 Bacteroides intestinalis 2984882 2985400 NZ_ABJL02000008.1 Bacteroides intestinalis 1297560 1297051 NZ_ABJL02000008.1 Bacteroides intestinalis 1656565 1656050 NZ_ACCL02000001.1 Marvinbryantia formatexigens 116305 116820 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1579965 1579402 NZ_ATFI01000002.1 Bacteroides cellulosilyticus 1183 659 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 389835 390377 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 572189 572641 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 229474 229983 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 48939 48499 NZ_CVOY01000018.1 Bacteroides thetaiotaomicron 29429 29977 NZ_CVOY01000040.1 Bacteroides thetaiotaomicron 40363 39824 NZ_CVOY01000042.1 Bacteroides thetaiotaomicron 62949 62425 NZ_CVOY01000048.1 Bacteroides thetaiotaomicron 31365 31859 NZ_DS264519.1 Parabacteroides merdae 6745 7230 NZ_DS264542.1 Parabacteroides merdae 249165 248725 NZ_DS264546.1 Parabacteroides merdae 3190 2678 NZ_DS264582.1 Bacteroides ovatus 368678 369202 NZ_DS264583.1 Bacteroides ovatus 339955 339416 NZ_DS362240.1 Bacteroides uniformis 130419 130928 NZ_DS362244.1 Bacteroides uniformis 170466 170960 NZ_DS362248.1 Bacteroides uniformis 308142 308660 NZ_DS480690.1 Clostridium bolteae 89583 90038 NZ_DS480690.1 Clostridium bolteae 244847 244362 NZ_DS480692.1 Clostridium bolteae 142221 141733 NZ_DS499655.1 Erysipelatoclostridium ramosum 354515 355036 NZ_DS499657.1 Erysipelatoclostridium ramosum 40323 39829 NZ_DS499672.1 Bacteroides stercoris 113142 113645 NZ_DS499673.1 Bacteroides stercoris 148946 149485 NZ_DS499674.1 Bacteroides stercoris 145503 146033 NZ_DS499697.1 Clostridium scindens 325349 325756 NZ_DS499701.1 Clostridium scindens 43469 43026 NZ_DS562853.1 Clostridium spiroforme 140554 141075 NZ_DS981517.1 Clostridium sporogenes 1671572 1672060 NZ_DS981517.1 Clostridium sporogenes 2367337 2367867 NZ_DS981517.1 Clostridium sporogenes 557173 557640 NZ_DS981518.1 Clostridium sporogenes 1128355 1127867 NZ_DS981518.1 Clostridium sporogenes 1189238 1189765 NZ_DS981518.1 Clostridium sporogenes 524044 524577 NZ_DS995509.1 Bacteroides eggerthii 1232496 1232957 NZ_DS995510.1 Bacteroides eggerthii 106112 106669 NZ_DS995510.1 Bacteroides eggerthii 730874 731398 NZ_DS995534.1 Bacteroides dorei 71649 71125 NZ_DS995536.1 Bacteroides dorei 38613 38149 NZ_DS995537.1 Bacteroides dorei 674934 674308 NZ_DS995537.1 Bacteroides dorei 634373 634867 NZ_DS996441.1 Parabacteroides johnsonii 40022 40534 NZ_DS996445.1 Parabacteroides johnsonii 6103 6588 NZ_DS996446.1 Parabacteroides johnsonii 59146 59586 NZ_DS996844.1 Holdemanella biformis 9192 9704 NZ_DS996847.1 Holdemanella biformis 35958 36458 NZ_EQ973488.1 Bacteroides cellulosilyticus 47287 46763 NZ_EQ973490.1 Bacteroides cellulosilyticus 1771328 1770765 NZ_EQ973491.1 Bacteroides cellulosilyticus 190402 189860 NZ_EQ973492.1 Bacteroides cellulosilyticus 269760 270200 NZ_EQ973495.1 Bacteroides cellulosilyticus 467156 466647 NZ_EQ973650.1 Bacteroides coprophilus 309687 310124 NZ_EQ973651.1 Bacteroides coprophilus 186888 186394 NZ_GG657592.1 Clostridium asparagiforme 256642 256139 NZ_GG657595.1 Clostridium asparagiforme 13750 13259 NZ_GG662014.1 Coprococcus comes 272777 273259 NZ_GG667651.1 Hungatella hathewayi 1953 2384 NZ_GG688331.1 Bacteroides finegoldii 31959 32501 NZ_GG688334.1 Bacteroides finegoldii 50722 51141 NZ_GG688343.1 Bacteroides finegoldii 10025 9501 NZ_GG692723.1 Roseburia intestinalis 45117 44662 NZ_GG698588.1 Blautia hansenii 717359 717898 NZ_GG698590.1 Blautia hansenii 424894 424328 NZ_GG698591.1 Blautia hansenii 291854 291342 NZ_GG703857.1 Prevotella copri 74622 74996 NZ_JGDE01000109.1 Bacteroides fragilis 17572 17084 NZ_JGDE01000119.1 Bacteroides fragilis 36868 36326 NZ_JGDE01000120.1 Bacteroides fragilis 100596 100087 NZ_JGDE01000126.1 Bacteroides fragilis 19672 19214 NZ_JH370371.1 Alistipes indistinctus 1207476 1206925 NZ_JH724294.1 Bacteroides xylanisolvens 1305623 1306168 NZ_JH724294.1 Bacteroides xylanisolvens 1743280 1743804 NZ_JH724297.1 Bacteroides xylanisolvens 31681 31157 NZ_JH724298.1 Bacteroides xylanisolvens 164880 165410 NZ_KE993038.1 Clostridium symbiosum 28562 29077 NZ_MTWC01000003.1 Clostridioides difficile 183069 182578 NZ_MTWC01000003.1 Clostridioides difficile 3694880 3694437 NZ_MTWC01000003.1 Clostridioides difficile 851750 852229 NZ_MTWC01000003.1 Clostridioides difficile 764218 764397 NZ_MTWD01000001.1 Clostridioides difficile 272104 271613 NZ_MTWD01000001.1 Clostridioides difficile 3699847 3699404 NZ_MTWD01000001.1 Clostridioides difficile 951766 952245 NZ_MTWD01000001.1 Clostridioides difficile 864276 864455 NZ_MTWE01000004.1 Clostridioides difficile 644539 645069 NZ_MTWE01000004.1 Clostridioides difficile 3362776 3362321 NZ_MTWE01000004.1 Clostridioides difficile 562108 562287 NZ_MTWF01000010.1 Clostridioides difficile 538767 539246 NZ_MTWF01000010.1 Clostridioides difficile 451166 451345 NZ_MTWF01000021.1 Clostridioides difficile 734552 734109 NZ_PUEM01000006.1 Clostridium bolteae 4759215 4759670 NZ_PUEM01000006.1 Clostridium bolteae 4326854 4327342 NZ_PUEM01000006.1 Clostridium bolteae 4914475 4913990 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1992590 1993129 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3444721 3444197 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3875031 3874483 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3235794 3235300 NZ_PUEP01000005.1 Bacteroides ovatus 2195846 2195307 NZ_PUEP01000005.1 Bacteroides ovatus 164812 165351 NZ_PUEP01000005.1 Bacteroides ovatus 1680431 1679907 NZ_PUEP01000005.1 Bacteroides ovatus 683462 683986 NZ_PUEQ01000002.1 Bacteroides caccae 164447 164986 NZ_PUEQ01000002.1 Bacteroides caccae 605566 606090 NZ_PUEQ01000003.1 Bacteroides caccae 1805586 1805047 NZ_PUEQ01000003.1 Bacteroides caccae 1408541 1408017 NZ_UFTH01000001.1 Bacteroides fragilis 276153 275611 NZ_UFTH01000001.1 Bacteroides fragilis 384961 384452 NZ_UFTH01000001.1 Bacteroides fragilis 627416 626958 NZ_UFTH01000002.1 Bacteroides fragilis 31630 32118 QEKH01000020.1 Victivallis vadensis 34973 35503 BACDOR_03937 21 270 CVOZ01000033.1 Bacteroides thetaiotaomicron 95366 94584 CVOZ01000058.1 Bacteroides thetaiotaomicron 56629 57405 CVOZ01000324.1 Bacteroides thetaiotaomicron 70 687 JGCP01002414.1 Bacteroides fragilis 51709 52458 NC_000913.3 Escherichia coli 3900130 3899411 NC_009614.1 Bacteroides vulgatus 3188040 3188789 NC_009615.1 Parabacteroides distasonis 3801181 3801927 NC_009615.1 Parabacteroides distasonis 2376805 2377560 NC_009615.1 Parabacteroides distasonis 3194728 3195453 NZ_AAVM02000004.1 Bacteroides caccae 216499 217236 NZ_ABJL02000001.1 Bacteroides intestinalis 92931 93386 NZ_ABJL02000007.1 Bacteroides intestinalis 250216 250953 NZ_ABJL02000007.1 Bacteroides intestinalis 251344 252009 NZ_ABJL02000007.1 Bacteroides intestinalis 167594 168043 NZ_ABJL02000008.1 Bacteroides intestinalis 1128321 1127566 NZ_ABJL02000008.1 Bacteroides intestinalis 2507054 2506242 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 437645 436902 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1152160 1151711 NZ_ATFI01000006.1 Bacteroides cellulosilyticus 51099 51554 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 397689 398429 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 325798 324986 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 23183 22401 NZ_CVOY01000040.1 Bacteroides thetaiotaomicron 78754 77978 NZ_DS264269.1 Eubacterium ventriosum 37509 38012 NZ_DS264541.1 Parabacteroides merdae 313249 313983 NZ_DS264541.1 Parabacteroides merdae 27165 26368 NZ_DS264554.1 Bacteroides ovatus 368625 369458 NZ_DS264554.1 Bacteroides ovatus 367145 367924 NZ_DS362233.1 Bacteroides uniformis 74458 73727 NZ_DS362239.1 Bacteroides uniformis 7728 6928 NZ_DS362239.1 Bacteroides uniformis 5192 4449 NZ_DS362239.1 Bacteroides uniformis 6443 5691 NZ_DS362240.1 Bacteroides uniformis 212961 213686 NZ_DS499653.1 Erysipelatoclostridium ramosum 194977 194246 NZ_DS499673.1 Bacteroides stercoris 206600 207376 NZ_DS607663.1 Providencia stuartii 1086289 1086999 NZ_DS995510.1 Bacteroides eggerthii 209136 209912 NZ_DS995510.1 Bacteroides eggerthii 640756 640298 NZ_DS995511.1 Bacteroides eggerthii 708500 707925 NZ_DS995511.1 Bacteroides eggerthii 707389 706949 NZ_DS995537.1 Bacteroides dorei 626439 627188 NZ_DS995537.1 Bacteroides dorei 1307660 1306917 NZ_DS996440.1 Parabacteroides johnsonii 32532 31852 NZ_DS996532.1 Parabacteroides johnsonii 832 98 NZ_DS996921.1 Bacteroides pectinophilus 1565959 1566558 NZ_EQ973489.1 Bacteroides cellulosilyticus 600373 600828 NZ_EQ973490.1 Bacteroides cellulosilyticus 549900 549157 NZ_EQ973490.1 Bacteroides cellulosilyticus 1229254 1228514 NZ_EQ973490.1 Bacteroides cellulosilyticus 1339191 1338574 NZ_EQ973490.1 Bacteroides cellulosilyticus 1228123 1227458 NZ_EQ973490.1 Bacteroides cellulosilyticus 1340362 1339898 NZ_EQ973490.1 Bacteroides cellulosilyticus 1351952 1351503 NZ_EQ973491.1 Bacteroides cellulosilyticus 776952 777764 NZ_EQ973495.1 Bacteroides cellulosilyticus 279328 278582 NZ_EQ973651.1 Bacteroides coprophilus 37045 36284 NZ_GG667608.1 Hungatella hathewayi 95881 95153 NZ_GG667608.1 Hungatella hathewayi 95064 94324 NZ_GG667610.1 Hungatella hathewayi 17497 18186 NZ_GG688325.1 Bacteroides finegoldii 120232 120978 NZ_GG692718.1 Roseburia intestinalis 47376 46933 NZ_GG704769.1 Subdoligranulum variabile 177725 178351 NZ_GG705264.1 Providencia rettgeri 106848 106150 NZ_JGDE01000048.1 Bacteroides fragilis 11596 12345 NZ_JH370371.1 Alistipes indistinctus 55352 54528 NZ_JH370371.1 Alistipes indistinctus 53842 52994 NZ_JH724294.1 Bacteroides xylanisolvens 1276319 1277065 NZ_KB946519.1 Enterococcus faecalis 364107 364844 NZ_MTWC01000003.1 Clostridioides difficile 2304288 2303677 NZ_MTWD01000001.1 Clostridioides difficile 2346466 2345855 NZ_MTWE01000004.1 Clostridioides difficile 2075445 2074834 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1959060 1959836 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 843141 843923 NZ_PUEP01000005.1 Bacteroides ovatus 2224578 2223826 NZ_PUEP01000005.1 Bacteroides ovatus 5227704 5226871 NZ_PUEP01000005.1 Bacteroides ovatus 5229184 5228405 NZ_PUEQ01000003.1 Bacteroides caccae 1833976 1833239 NZ_UFTH01000001.1 Bacteroides fragilis 3547971 3548720 QEKH01000010.1 Victivallis vadensis 10220 9546 BACDOR_03988 38 188 CVOZ01000058.1 Bacteroides thetaiotaomicron 139616 140215 JGCP01002512.1 Bacteroides fragilis 11361 10762 NC_009615.1 Parabacteroides distasonis 4480120 4479551 NC_010655.1 Akkermansia muciniphila 306289 306831 NC_010655.1 Akkermansia muciniphila 905733 906320 NZ_AAVM02000004.1 Bacteroides caccae 286126 286725 NZ_ABJL02000008.1 Bacteroides intestinalis 1732043 1731456 NZ_ATFI01000002.1 Bacteroides cellulosilyticus 82757 82170 NZ_CVOY01000066.1 Bacteroides thetaiotaomicron 9741 10340 NZ_DS264527.1 Parabacteroides merdae 217241 217831 NZ_DS264563.1 Bacteroides ovatus 4980 5579 NZ_DS996456.1 Parabacteroides johnsonii 597619 598122 NZ_EQ973488.1 Bacteroides cellulosilyticus 180842 180255 NZ_GG688325.1 Bacteroides finegoldii 190680 191279 NZ_JGDE01000119.1 Bacteroides fragilis 11369 10770 NZ_JH370372.1 Alistipes indistinctus 150396 149821 NZ_JH724294.1 Bacteroides xylanisolvens 1356697 1357296 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2041862 2042461 NZ_PUEP01000005.1 Bacteroides ovatus 2145744 2145145 NZ_PUEQ01000003.1 Bacteroides caccae 1764349 1763750 NZ_UFTH01000001.1 Bacteroides fragilis 250655 250056 QEKH01000037.1 Victivallis vadensis 41431 42000 BT_1192 225 462 COLAER_00815 63 152 CVOZ01000044.1 Bacteroides thetaiotaomicron 36179 35082 NZ_ABJL02000008.1 Bacteroides intestinalis 751517 750519 NZ_ACCL02000009.1 Marvinbryantia formatexigens 60051 59242 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 225054 224056 NZ_CVOY01000094.1 Bacteroides thetaiotaomicron 5257 4160 NZ_EQ973492.1 Bacteroides cellulosilyticus 68742 69740 NZ_GG693664.1 Lactobacillus reuteri 69369 68959 NZ_GG703857.1 Prevotella copri 120565 119489 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2345451 2344354 BACDOR_00665 17 220 BT_4075 18 237 BT_4096 15 233 CVOZ01000033.1 Bacteroides thetaiotaomicron 61351 60695 CVOZ01000033.1 Bacteroides thetaiotaomicron 99554 98895 CVOZ01000053.1 Bacteroides thetaiotaomicron 57335 56628 JGCP01002366.1 Bacteroides fragilis 7385 6810 JGCP01002441.1 Bacteroides fragilis 9886 10419 JGCP01002552.1 Bacteroides fragilis 31062 31763 NC_009614.1 Bacteroides vulgatus 5100285 5099674 NC_009615.1 Parabacteroides distasonis 1134973 1135647 NC_009615.1 Parabacteroides distasonis 3795095 3795700 NZ_AAVM02000001.1 Bacteroides caccae 1240752 1240264 NZ_AAYG02000020.1 Ruminococcus gnavus 146634 146014 NZ_ABJL02000006.1 Bacteroides intestinalis 363959 364528 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 142540 143115 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 11055 11711 NZ_CVOY01000005.1 Bacteroides thetaiotaomicron 209350 210054 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 27372 26713 NZ_DS264582.1 Bacteroides ovatus 46805 46104 NZ_DS362220.1 Bacteroides uniformis 17220 16552 NZ_DS362220.1 Bacteroides uniformis 323305 322706 NZ_DS362233.1 Bacteroides uniformis 68158 68733 NZ_DS995510.1 Bacteroides eggerthii 656648 657349 NZ_DS995531.1 Bacteroides dorei 447861 448472 NZ_EQ973490.1 Bacteroides cellulosilyticus 916393 917094 NZ_EQ973490.1 Bacteroides cellulosilyticus 257437 258012 NZ_GG688322.1 Bacteroides finegoldii 129507 130208 NZ_JGDE01000017.1 Bacteroides fragilis 7446 6871 NZ_JGDE01000072.1 Bacteroides fragilis 9365 9898 NZ_JGDE01000136.1 Bacteroides fragilis 27192 27893 NZ_JH370372.1 Alistipes indistinctus 98423 97836 NZ_JH724294.1 Bacteroides xylanisolvens 2429590 2428892 NZ_JH724294.1 Bacteroides xylanisolvens 357558 358211 NZ_MTWC01000003.1 Clostridioides difficile 1624066 1624641 NZ_MTWD01000001.1 Clostridioides difficile 1671881 1672456 NZ_MTWE01000004.1 Clostridioides difficile 1376453 1377028 NZ_PUEL01000004.1 Ruminococcus gnavus 1632369 1631749 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2506871 2507578 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 877155 877811 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 838952 839611 NZ_PUEP01000005.1 Bacteroides ovatus 917568 918269 NZ_PUEQ01000003.1 Bacteroides caccae 1529561 1529073 NZ_UFTH01000001.1 Bacteroides fragilis 1188601 1189302 NZ_UFTH01000001.1 Bacteroides fragilis 4050588 4051193 NZ_UFTH01000001.1 Bacteroides fragilis 2389555 2388980 QEKH01000001.1 Victivallis vadensis 111269 110676 QEKH01000033.1 Victivallis vadensis 30181 29585 BACDOR_03988 47 114 BT_1148 1 64 COLAER_01707 1 61 CVOZ01000045.1 Bacteroides thetaiotaomicron 71534 72259 JGCP01002519.1 Bacteroides fragilis 4300 3575 NC_009614.1 Bacteroides vulgatus 2641382 2642107 NC_009615.1 Parabacteroides distasonis 3958482 3959207 NZ_ABJL02000008.1 Bacteroides intestinalis 196383 195658 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 165083 165808 NZ_CVOY01000055.1 Bacteroides thetaiotaomicron 66645 67370 NZ_EQ973492.1 Bacteroides cellulosilyticus 685757 686482 NZ_JGDE01000121.1 Bacteroides fragilis 3841 3116 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3056168 3055443 NZ_UFTH01000001.1 Bacteroides fragilis 475905 475180 BACDOR_00571 1 161 BACDOR_03988 38 188 BT_1006 1 62 COLAER_01707 2 173 CVOZ01000022.1 Bacteroides thetaiotaomicron 97011 97409 CVOZ01000044.1 Bacteroides thetaiotaomicron 270166 270732 CVOZ01000058.1 Bacteroides thetaiotaomicron 90387 90851 JGCP01000803.1 Bacteroides fragilis 3189 3539 JGCP01001429.1 Bacteroides fragilis 368 33 JGCP01002451.1 Bacteroides fragilis 27266 27829 JGCP01002513.1 Bacteroides fragilis 8383 8045 JGCP01002532.1 Bacteroides fragilis 1981 1547 NC_000913.3 Escherichia coli 1848673 1848173 NC_009614.1 Bacteroides vulgatus 1289411 1288926 NC_009614.1 Bacteroides vulgatus 3238587 3238135 NC_009614.1 Bacteroides vulgatus 2553354 2553794 NC_009614.1 Bacteroides vulgatus 3195969 3196346 NC_009615.1 Parabacteroides distasonis 185234 184872 NC_009615.1 Parabacteroides distasonis 2044480 2044818 NC_009615.1 Parabacteroides distasonis 178506 178946 NC_012781.1 Eubacterium rectale 1600351 1600812 NZ_AAVM02000001.1 Bacteroides caccae 1119739 1119173 NZ_AAVM02000004.1 Bacteroides caccae 244931 245413 NZ_AAVM02000006.1 Bacteroides caccae 117419 117811 NZ_AAVN02000007.1 Collinsella aerofaciens 43331 42861 NZ_AAXA02000015.1 Dorea formicigenerans 428149 428610 NZ_AAXA02000015.1 Dorea formicigenerans 92548 92081 NZ_AAXA02000015.1 Dorea formicigenerans 812479 812928 NZ_AAYG02000005.1 Ruminococcus gnavus 169541 170062 NZ_ABJL02000007.1 Bacteroides intestinalis 959657 959169 NZ_ABJL02000008.1 Bacteroides intestinalis 574722 574159 NZ_ABJL02000008.1 Bacteroides intestinalis 1297560 1297120 NZ_ABJL02000008.1 Bacteroides intestinalis 1656580 1656089 NZ_ABXA01000011.1 Anaerococcus hydrogenalis 17304 16843 NZ_ABXA01000037.1 Anaerococcus hydrogenalis 15306 14824 NZ_ABXW01000046.1 Providencia alcalifaciens 53440 52970 NZ_ACCL02000007.1 Marvinbryantia formatexigens 30293 30754 NZ_ACEP01000002.1 Eubacterium hallii 34252 34719 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1579908 1579426 NZ_ATFI01000002.1 Bacteroides cellulosilyticus 1189 698 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 572171 572605 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 389868 390314 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 229474 229914 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 48939 48385 NZ_CVOY01000018.1 Bacteroides thetaiotaomicron 29468 29866 NZ_CVOY01000040.1 Bacteroides thetaiotaomicron 40321 39857 NZ_CVOY01000048.1 Bacteroides thetaiotaomicron 31356 31922 NZ_DS264270.1 Eubacterium ventriosum 212229 212735 NZ_DS264519.1 Parabacteroides merdae 6745 7185 NZ_DS264542.1 Parabacteroides merdae 249186 248728 NZ_DS264546.1 Parabacteroides merdae 3190 2741 NZ_DS264582.1 Bacteroides ovatus 368669 369235 NZ_DS264583.1 Bacteroides ovatus 339925 339533 NZ_DS362240.1 Bacteroides uniformis 130419 130859 NZ_DS362244.1 Bacteroides uniformis 170466 171023 NZ_DS362248.1 Bacteroides uniformis 308148 308636 NZ_DS480690.1 Clostridium bolteae 244847 244389 NZ_DS480690.1 Clostridium bolteae 89559 89996 NZ_DS480692.1 Clostridium bolteae 142191 141730 NZ_DS480699.1 Clostridium bolteae 65753 65265 NZ_DS480702.1 Clostridium bolteae 207090 207605 NZ_DS499655.1 Erysipelatoclostridium ramosum 354515 355066 NZ_DS499657.1 Erysipelatoclostridium ramosum 40329 39883 NZ_DS499659.1 Erysipelatoclostridium ramosum 548777 548307 NZ_DS499671.1 Bacteroides stercoris 218970 218503 NZ_DS499672.1 Bacteroides stercoris 113148 113708 NZ_DS499673.1 Bacteroides stercoris 148976 149359 NZ_DS499674.1 Bacteroides stercoris 145533 146009 NZ_DS499697.1 Clostridium scindens 325331 325762 NZ_DS499701.1 Clostridium scindens 43475 43014 NZ_DS544193.1 Anaerotruncus colihominis 200255 200710 NZ_DS562846.1 Clostridium spiroforme 146415 145894 NZ_DS562853.1 Clostridium spiroforme 140554 141045 NZ_DS981517.1 Clostridium sporogenes 2367337 2367828 NZ_DS981517.1 Clostridium sporogenes 1671572 1672009 NZ_DS981517.1 Clostridium sporogenes 557155 557655 NZ_DS981518.1 Clostridium sporogenes 1189250 1189702 NZ_DS990201.1 Ruminococcus lactaris 50102 50560 NZ_DS995509.1 Bacteroides eggerthii 1232487 1232954 NZ_DS995510.1 Bacteroides eggerthii 730874 731431 NZ_DS995510.1 Bacteroides eggerthii 106160 106552 NZ_DS995511.1 Bacteroides eggerthii 244985 245470 NZ_DS995534.1 Bacteroides dorei 71655 71170 NZ_DS995536.1 Bacteroides dorei 38613 38173 NZ_DS995537.1 Bacteroides dorei 674823 674371 NZ_DS995537.1 Bacteroides dorei 634364 634741 NZ_DS996445.1 Parabacteroides johnsonii 6103 6543 NZ_DS996446.1 Parabacteroides johnsonii 59125 59583 NZ_DS996841.1 Holdemanella biformis 240826 240371 NZ_DS996847.1 Holdemanella biformis 35961 36428 NZ_DS996921.1 Bacteroides pectinophilus 1377567 1378028 NZ_EQ973488.1 Bacteroides cellulosilyticus 47293 46802 NZ_EQ973490.1 Bacteroides cellulosilyticus 1771271 1770789 NZ_EQ973491.1 Bacteroides cellulosilyticus 190369 189923 NZ_EQ973492.1 Bacteroides cellulosilyticus 269760 270314 NZ_EQ973495.1 Bacteroides cellulosilyticus 467156 466716 NZ_EQ973631.1 Bacteroides coprophilus 166054 166542 NZ_EQ973635.1 Bacteroides coprophilus 157971 157459 NZ_EQ973650.1 Bacteroides coprophilus 309687 310166 NZ_EQ973651.1 Bacteroides coprophilus 186897 186505 NZ_GG657592.1 Clostridium asparagiforme 256642 256181 NZ_GG657592.1 Clostridium asparagiforme 2004031 2003507 NZ_GG662012.1 Coprococcus comes 43447 42971 NZ_GG662014.1 Coprococcus comes 263238 263699 NZ_GG662014.1 Coprococcus comes 272789 273202 NZ_GG667651.1 Hungatella hathewayi 1938 2414 NZ_GG667669.1 Hungatella hathewayi 6018 5659 NZ_GG688323.1 Bacteroides finegoldii 185586 185020 NZ_GG688331.1 Bacteroides finegoldii 31992 32390 NZ_GG688334.1 Bacteroides finegoldii 50704 51138 NZ_GG688343.1 Bacteroides finegoldii 10043 9534 NZ_GG692721.1 Roseburia intestinalis 15570 16028 NZ_GG692723.1 Roseburia intestinalis 45141 44704 NZ_GG698588.1 Blautia hansenii 717392 717745 NZ_GG698590.1 Blautia hansenii 424876 424454 NZ_GG698591.1 Blautia hansenii 291860 291414 NZ_GG703859.1 Prevotella copri 138304 138762 NZ_GG704769.1 Subdoligranulum variabile 1245795 1245319 NZ_GG704863.1 Enterobacter cancerogenus 743021 743521 NZ_GG705262.1 Providencia rettgeri 266718 267200 NZ_JGDE01000083.1 Bacteroides fragilis 52773 53336 NZ_JGDE01000119.1 Bacteroides fragilis 36826 36488 NZ_JGDE01000120.1 Bacteroides fragilis 100596 100204 NZ_JGDE01000126.1 Bacteroides fragilis 19690 19256 NZ_JH370371.1 Alistipes indistinctus 1289797 1289312 NZ_JH724294.1 Bacteroides xylanisolvens 1743271 1743837 NZ_JH724294.1 Bacteroides xylanisolvens 1305671 1306153 NZ_JH724298.1 Bacteroides xylanisolvens 164868 165341 NZ_KE993038.1 Clostridium symbiosum 28568 29044 NZ_MTWC01000003.1 Clostridioides difficile 764209 764835 NZ_MTWC01000003.1 Clostridioides difficile 851741 852184 NZ_MTWC01000003.1 Clostridioides difficile 2732784 2732185 NZ_MTWC01000003.1 Clostridioides difficile 699115 699672 NZ_MTWC01000003.1 Clostridioides difficile 183072 182623 NZ_MTWC01000003.1 Clostridioides difficile 3541722 3542282 NZ_MTWD01000001.1 Clostridioides difficile 864267 864893 NZ_MTWD01000001.1 Clostridioides difficile 951757 952200 NZ_MTWD01000001.1 Clostridioides difficile 2768710 2768111 NZ_MTWD01000001.1 Clostridioides difficile 797509 798066 NZ_MTWD01000001.1 Clostridioides difficile 272107 271658 NZ_MTWD01000001.1 Clostridioides difficile 3546771 3547331 NZ_MTWE01000004.1 Clostridioides difficile 3086150 3086647 NZ_MTWE01000004.1 Clostridioides difficile 644551 645006 NZ_MTWE01000004.1 Clostridioides difficile 562099 562725 NZ_MTWE01000004.1 Clostridioides difficile 2485446 2484847 NZ_MTWE01000004.1 Clostridioides difficile 496166 496723 NZ_MTWE01000004.1 Clostridioides difficile 3212349 3212909 NZ_MTWF01000010.1 Clostridioides difficile 451157 451783 NZ_MTWF01000010.1 Clostridioides difficile 538758 539201 NZ_MTWF01000010.1 Clostridioides difficile 384824 385381 NZ_MTWF01000021.1 Clostridioides difficile 587932 588492 NZ_PPUH01000002.1 Eggerthella lenta 235526 235999 NZ_PUEL01000004.1 Ruminococcus gnavus 215279 214758 NZ_PUEM01000006.1 Clostridium bolteae 4914475 4914017 NZ_PUEM01000006.1 Clostridium bolteae 4326884 4327345 NZ_PUEM01000006.1 Clostridium bolteae 105784 105296 NZ_PUEM01000006.1 Clostridium bolteae 4759191 4759628 NZ_PUEM01000006.1 Clostridium bolteae 3928704 3928189 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3235803 3235237 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3874992 3874594 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1992632 1993096 NZ_PUEP01000005.1 Bacteroides ovatus 1680440 1679874 NZ_PUEP01000005.1 Bacteroides ovatus 2195804 2195322 NZ_PUEP01000005.1 Bacteroides ovatus 164842 165234 NZ_PUEP01000005.1 Bacteroides ovatus 562300 561950 NZ_PUEQ01000002.1 Bacteroides caccae 164477 164869 NZ_PUEQ01000003.1 Bacteroides caccae 1408550 1407984 NZ_PUEQ01000003.1 Bacteroides caccae 1805544 1805062 NZ_UFTH01000001.1 Bacteroides fragilis 4377465 4378028 NZ_UFTH01000001.1 Bacteroides fragilis 384961 384569 NZ_UFTH01000001.1 Bacteroides fragilis 276111 275773 NZ_UFTH01000001.1 Bacteroides fragilis 627434 627000 QEKH01000007.1 Victivallis vadensis 148157 147966 QEKH01000020.1 Victivallis vadensis 34991 35440 BACDOR_03642 199 294 BT_0445 108 355 BT_3112 198 273 BT_4096 25 227 COLAER_00311 4 141 COLAER_01894 100 223 CVOZ01000002.1 Bacteroides thetaiotaomicron 27517 28095 CVOZ01000022.1 Bacteroides thetaiotaomicron 18764 19381 CVOZ01000033.1 Bacteroides thetaiotaomicron 94159 93596 CVOZ01000044.1 Bacteroides thetaiotaomicron 154575 155963 CVOZ01000044.1 Bacteroides thetaiotaomicron 288279 287539 CVOZ01000044.1 Bacteroides thetaiotaomicron 54111 54704 CVOZ01000045.1 Bacteroides thetaiotaomicron 69771 70430 JGCP01000579.1 Bacteroides fragilis 101 835 JGCP01001396.1 Bacteroides fragilis 73 648 JGCP01001597.1 Bacteroides fragilis 35746 35105 JGCP01001863.1 Bacteroides fragilis 3013 2438 JGCP01002141.1 Bacteroides fragilis 80 562 JGCP01002441.1 Bacteroides fragilis 10488 11063 JGCP01002451.1 Bacteroides fragilis 42494 41802 JGCP01002459.1 Bacteroides fragilis 73942 74622 NC_008618.1 Bifidobacterium adolescentis 551869 551261 NC_008618.1 Bifidobacterium adolescentis 1949407 1950006 NC_009614.1 Bacteroides vulgatus 768330 769709 NC_009614.1 Bacteroides vulgatus 3519215 3518526 NC_009614.1 Bacteroides vulgatus 5099605 5099030 NC_009615.1 Parabacteroides distasonis 2089648 2090340 NC_009615.1 Parabacteroides distasonis 3529426 3530001 NC_009615.1 Parabacteroides distasonis 421342 422067 NC_010655.1 Akkermansia muciniphila 236748 237500 NC_010655.1 Akkermansia muciniphila 1519934 1520518 NC_010655.1 Akkermansia muciniphila 543429 544073 NZ_AAVM02000001.1 Bacteroides caccae 1170612 1169452 NZ_AAVM02000001.1 Bacteroides caccae 1240152 1239577 NZ_AAVM02000001.1 Bacteroides caccae 1169494 1169237 NZ_AAVN02000002.1 Collinsella aerofaciens 333786 333019 NZ_AAVN02000003.1 Collinsella aerofaciens 209264 210085 NZ_AAXA02000013.1 Dorea formicigenerans 16343 17014 NZ_ABJL02000007.1 Bacteroides intestinalis 1098860 1099444 NZ_ABJL02000008.1 Bacteroides intestinalis 382787 383479 NZ_ACCL02000033.1 Marvinbryantia formatexigens 12876 12274 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1683794 1684420 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1683052 1683747 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1782879 1783463 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1678134 1678772 NZ_ATFI01000003.1 Bacteroides cellulosilyticus 171894 171202 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 21976 21413 NZ_CVOY01000035.1 Bacteroides thetaiotaomicron 60758 62146 NZ_CVOY01000041.1 Bacteroides thetaiotaomicron 67133 66540 NZ_CVOY01000048.1 Bacteroides thetaiotaomicron 49341 48601 NZ_CVOY01000055.1 Bacteroides thetaiotaomicron 64881 65540 NZ_CVOY01000056.1 Bacteroides thetaiotaomicron 28539 27919 NZ_DS264285.1 Eubacterium ventriosum 234482 233679 NZ_DS264345.1 Ruminococcus torques 463019 463708 NZ_DS264358.1 Ruminococcus torques 67993 67382 NZ_DS264461.1 Parabacteroides merdae 326010 326663 NZ_DS264517.1 Parabacteroides merdae 22263 22925 NZ_DS264542.1 Parabacteroides merdae 81508 82206 NZ_DS264546.1 Parabacteroides merdae 423018 422293 NZ_DS264582.1 Bacteroides ovatus 312464 313840 NZ_DS264582.1 Bacteroides ovatus 385872 385138 NZ_DS264584.1 Bacteroides ovatus 360662 360078 NZ_DS362246.1 Bacteroides uniformis 266126 266818 NZ_DS480676.1 Clostridium bolteae 34484 35167 NZ_DS499671.1 Bacteroides stercoris 178076 178768 NZ_DS499699.1 Clostridium scindens 152903 153694 NZ_DS990204.1 Ruminococcus lactaris 12440 11805 NZ_DS990238.1 Bifidobacterium longum 835334 835945 NZ_DS995510.1 Bacteroides eggerthii 1068518 1069210 NZ_DS995531.1 Bacteroides dorei 448541 449116 NZ_DS995532.1 Bacteroides dorei 204439 203063 NZ_DS995537.1 Bacteroides dorei 1066363 1065647 NZ_DS996444.1 Parabacteroides johnsonii 692206 692904 NZ_DS996444.1 Parabacteroides johnsonii 534772 535347 NZ_DS996445.1 Parabacteroides johnsonii 312362 312937 NZ_DS996445.1 Parabacteroides johnsonii 311498 312121 NZ_DS996453.1 Parabacteroides johnsonii 2533 1928 NZ_DS996454.1 Parabacteroides johnsonii 206111 205386 NZ_DS996921.1 Bacteroides pectinophilus 286605 285892 NZ_DS996921.1 Bacteroides pectinophilus 2101527 2100832 NZ_EQ973490.1 Bacteroides cellulosilyticus 1876241 1876867 NZ_EQ973490.1 Bacteroides cellulosilyticus 1875499 1876194 NZ_EQ973490.1 Bacteroides cellulosilyticus 1993710 1994294 NZ_EQ973490.1 Bacteroides cellulosilyticus 1870581 1871219 NZ_EQ973492.1 Bacteroides cellulosilyticus 515707 515015 NZ_EQ973635.1 Bacteroides coprophilus 234153 233497 NZ_EQ973643.1 Bacteroides coprophilus 430594 431154 NZ_EQ973645.1 Bacteroides coprophilus 64093 64677 NZ_GG657587.1 Clostridium asparagiforme 608304 607693 NZ_GG688324.1 Bacteroides finegoldii 240097 241473 NZ_GG692719.1 Roseburia intestinalis 133882 133238 NZ_GG692722.1 Roseburia intestinalis 102286 101618 NZ_GG698591.1 Blautia hansenii 190916 190320 NZ_GG703852.1 Prevotella copri 38955 39719 NZ_GG704769.1 Subdoligranulum variabile 1468443 1469039 NZ_JGDE01000072.1 Bacteroides fragilis 9967 10542 NZ_JGDE01000083.1 Bacteroides fragilis 68003 67311 NZ_JGDE01000090.1 Bacteroides fragilis 28577 29257 NZ_JGDE01000151.1 Bacteroides fragilis 44141 43500 NZ_JH370371.1 Alistipes indistinctus 1345780 1345082 NZ_JH370371.1 Alistipes indistinctus 1448027 1447329 NZ_JH370371.1 Alistipes indistinctus 1079496 1078762 NZ_JH370372.1 Alistipes indistinctus 982398 983033 NZ_JH724294.1 Bacteroides xylanisolvens 1686417 1687793 NZ_JH724294.1 Bacteroides xylanisolvens 1760534 1759800 NZ_JH724300.1 Bacteroides xylanisolvens 30471 31202 NZ_PUEL01000004.1 Ruminococcus gnavus 1481589 1480987 NZ_PUEM01000006.1 Clostridium bolteae 1700445 1699762 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 234534 233911 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 909823 909245 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3291162 3289774 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3176085 3176825 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3057931 3057272 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 844348 844911 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2363382 2363975 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3953243 3952623 NZ_PUEP01000005.1 Bacteroides ovatus 1736646 1735270 NZ_PUEP01000005.1 Bacteroides ovatus 1663236 1663970 NZ_PUEP01000005.1 Bacteroides ovatus 3085087 3085671 NZ_PUEQ01000003.1 Bacteroides caccae 1459423 1458263 NZ_PUEQ01000003.1 Bacteroides caccae 1528961 1528386 NZ_PUEQ01000003.1 Bacteroides caccae 1458305 1458048 NZ_UFTH01000001.1 Bacteroides fragilis 4392695 4392003 NZ_UFTH01000001.1 Bacteroides fragilis 1560134 1559493 NZ_UFTH01000001.1 Bacteroides fragilis 4539896 4540576 NZ_UFTH01000001.1 Bacteroides fragilis 4051262 4051837 QEKH01000002.1 Victivallis vadensis 212329 213045 QEKH01000007.1 Victivallis vadensis 28585 27923 QEKH01000045.1 Victivallis vadensis 12920 13444 QEKH01000049.1 Victivallis vadensis 19550 18807 CVOZ01000063.1 Bacteroides thetaiotaomicron 94029 94442 CVOZ01000063.1 Bacteroides thetaiotaomicron 147334 147705 JGCP01000058.1 Bacteroides fragilis 518 925 JGCP01002489.1 Bacteroides fragilis 518 925 JGCP01002505.1 Bacteroides fragilis 555 148 NC_009614.1 Bacteroides vulgatus 910468 910875 NC_009615.1 Parabacteroides distasonis 2405517 2405906 NZ_AAVM02000005.1 Bacteroides caccae 97107 97520 NZ_AAVM02000005.1 Bacteroides caccae 155081 155452 NZ_ABJL02000008.1 Bacteroides intestinalis 642857 643258 NZ_ABJL02000008.1 Bacteroides intestinalis 2029709 2030089 NZ_ABJL02000008.1 Bacteroides intestinalis 1716117 1715746 NZ_ATFI01000002.1 Bacteroides cellulosilyticus 74483 74112 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 122628 123029 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 191727 192140 NZ_CVOY01000058.1 Bacteroides thetaiotaomicron 28964 28593 NZ_DS264541.1 Parabacteroides merdae 67177 66776 NZ_DS362236.1 Bacteroides uniformis 38489 38878 NZ_DS362245.1 Bacteroides uniformis 24062 24184 NZ_DS362245.1 Bacteroides uniformis 24267 24356 NZ_DS362245.1 Bacteroides uniformis 24193 24264 NZ_DS480694.1 Clostridium bolteae 252033 252386 NZ_DS499718.1 Clostridium scindens 309983 309654 NZ_DS995528.1 Bacteroides dorei 127411 127812 NZ_DS995533.1 Bacteroides dorei 131728 131327 NZ_DS996447.1 Parabacteroides johnsonii 92123 91722 NZ_DS996455.1 Parabacteroides johnsonii 41510 41118 NZ_DS996455.1 Parabacteroides johnsonii 41091 40711 NZ_EQ973488.1 Bacteroides cellulosilyticus 155148 154777 NZ_EQ973492.1 Bacteroides cellulosilyticus 200913 200512 NZ_GG657592.1 Clostridium asparagiforme 560671 561042 NZ_GG667665.1 Hungatella hathewayi 3412 3059 NZ_GG688317.1 Bacteroides finegoldii 373129 372716 NZ_GG688317.1 Bacteroides finegoldii 351401 351003 NZ_JGDE01000115.1 Bacteroides fragilis 2024 1617 NZ_JH370371.1 Alistipes indistinctus 1113682 1114062 NZ_JH724297.1 Bacteroides xylanisolvens 171556 171143 NZ_JH724297.1 Bacteroides xylanisolvens 107227 106856 NZ_PUEM01000006.1 Clostridium bolteae 5784734 5784381 NZ_AAVN02000003.1 Collinsella aerofaciens 209264 210085 NZ_AAXA02000013.1 Dorea formicigenerans 16343 17014 NZ_ABJL02000007.1 Bacteroides intestinalis 1098860 1099444 NZ_ABJL02000008.1 Bacteroides intestinalis 382787 383479 NZ_ACCL02000033.1 Marvinbryantia formatexigens 12876 12274 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1683794 1684420 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1683052 1683747 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1782879 1783463 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1678134 1678772 NZ_ATFI01000003.1 Bacteroides cellulosilyticus 171894 171202 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 21976 21413 NZ_CVOY01000035.1 Bacteroides thetaiotaomicron 60758 62146 NZ_CVOY01000041.1 Bacteroides thetaiotaomicron 67133 66540 NZ_CVOY01000048.1 Bacteroides thetaiotaomicron 49341 48601 NZ_CVOY01000055.1 Bacteroides thetaiotaomicron 64881 65540 NZ_CVOY01000056.1 Bacteroides thetaiotaomicron 28539 27919 NZ_DS264285.1 Eubacterium ventriosum 234482 233679 NZ_DS264345.1 Ruminococcus torques 463019 463708 NZ_DS264358.1 Ruminococcus torques 67993 67382 NZ_DS264461.1 Parabacteroides merdae 326010 326663 NZ_DS264517.1 Parabacteroides merdae 22263 22925 NZ_DS264542.1 Parabacteroides merdae 81508 82206 NZ_DS264546.1 Parabacteroides merdae 423018 422293 NZ_DS264582.1 Bacteroides ovatus 312464 313840 NZ_DS264582.1 Bacteroides ovatus 385872 385138 NZ_DS264584.1 Bacteroides ovatus 360662 360078 NZ_DS362246.1 Bacteroides uniformis 266126 266818 NZ_DS480676.1 Clostridium bolteae 34484 35167 NZ_DS499671.1 Bacteroides stercoris 178076 178768 NZ_DS499699.1 Clostridium scindens 152903 153694 NZ_DS990204.1 Ruminococcus lactaris 12440 11805 NZ_DS990238.1 Bifidobacterium longum 835334 835945 NZ_DS995510.1 Bacteroides eggerthii 1068518 1069210 NZ_DS995531.1 Bacteroides dorei 448541 449116 NZ_DS995532.1 Bacteroides dorei 204439 203063 NZ_DS995537.1 Bacteroides dorei 1066363 1065647 NZ_DS996444.1 Parabacteroides johnsonii 692206 692904 NZ_DS996444.1 Parabacteroides johnsonii 534772 535347 NZ_DS996445.1 Parabacteroides johnsonii 312362 312937 NZ_DS996445.1 Parabacteroides johnsonii 311498 312121 NZ_DS996453.1 Parabacteroides johnsonii 2533 1928 NZ_DS996454.1 Parabacteroides johnsonii 206111 205386 NZ_DS996921.1 Bacteroides pectinophilus 286605 285892 NZ_DS996921.1 Bacteroides pectinophilus 2101527 2100832 NZ_EQ973490.1 Bacteroides cellulosilyticus 1876241 1876867 NZ_EQ973490.1 Bacteroides cellulosilyticus 1875499 1876194 NZ_EQ973490.1 Bacteroides cellulosilyticus 1993710 1994294 NZ_EQ973490.1 Bacteroides cellulosilyticus 1870581 1871219 NZ_EQ973492.1 Bacteroides cellulosilyticus 515707 515015 NZ_EQ973635.1 Bacteroides coprophilus 234153 233497 NZ_EQ973643.1 Bacteroides coprophilus 430594 431154 NZ_EQ973645.1 Bacteroides coprophilus 64093 64677 NZ_GG657587.1 Clostridium asparagiforme 608304 607693 NZ_GG688324.1 Bacteroides finegoldii 240097 241473 NZ_GG692719.1 Roseburia intestinalis 133882 133238 NZ_GG692722.1 Roseburia intestinalis 102286 101618 NZ_GG698591.1 Blautia hansenii 190916 190320 NZ_GG703852.1 Prevotella copri 38955 39719 NZ_GG704769.1 Subdoligranulum variabile 1468443 1469039 NZ_JGDE01000072.1 Bacteroides fragilis 9967 10542 NZ_JGDE01000083.1 Bacteroides fragilis 68003 67311 NZ_JGDE01000090.1 Bacteroides fragilis 28577 29257 NZ_JGDE01000151.1 Bacteroides fragilis 44141 43500 NZ_JH370371.1 Alistipes indistinctus 1345780 1345082 NZ_JH370371.1 Alistipes indistinctus 1448027 1447329 NZ_JH370371.1 Alistipes indistinctus 1079496 1078762 NZ_JH370372.1 Alistipes indistinctus 982398 983033 NZ_JH724294.1 Bacteroides xylanisolvens 1686417 1687793 NZ_JH724294.1 Bacteroides xylanisolvens 1760534 1759800 NZ_JH724300.1 Bacteroides xylanisolvens 30471 31202 NZ_PUEL01000004.1 Ruminococcus gnavus 1481589 1480987 NZ_PUEM01000006.1 Clostridium bolteae 1700445 1699762 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 234534 233911 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 909823 909245 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3291162 3289774 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3176085 3176825 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3057931 3057272 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 844348 844911 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2363382 2363975 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3953243 3952623 NZ_PUEP01000005.1 Bacteroides ovatus 1736646 1735270 NZ_PUEP01000005.1 Bacteroides ovatus 1663236 1663970 NZ_PUEP01000005.1 Bacteroides ovatus 3085087 3085671 NZ_PUEQ01000003.1 Bacteroides caccae 1459423 1458263 NZ_PUEQ01000003.1 Bacteroides caccae 1528961 1528386 NZ_PUEQ01000003.1 Bacteroides caccae 1458305 1458048 NZ_UFTH01000001.1 Bacteroides fragilis 4392695 4392003 NZ_UFTH01000001.1 Bacteroides fragilis 1560134 1559493 NZ_UFTH01000001.1 Bacteroides fragilis 4539896 4540576 NZ_UFTH01000001.1 Bacteroides fragilis 4051262 4051837 QEKH01000002.1 Victivallis vadensis 212329 213045 QEKH01000007.1 Victivallis vadensis 28585 27923 QEKH01000045.1 Victivallis vadensis 12920 13444 QEKH01000049.1 Victivallis vadensis 19550 18807 CVOZ01000063.1 Bacteroides thetaiotaomicron 94029 94442 CVOZ01000063.1 Bacteroides thetaiotaomicron 147334 147705 JGCP01000058.1 Bacteroides fragilis 518 925 JGCP01002489.1 Bacteroides fragilis 518 925 JGCP01002505.1 Bacteroides fragilis 555 148 NC_009614.1 Bacteroides vulgatus 910468 910875 NC_009615.1 Parabacteroides distasonis 2405517 2405906 NZ_AAVM02000005.1 Bacteroides caccae 97107 97520 NZ_AAVM02000005.1 Bacteroides caccae 155081 155452 NZ_ABJL02000008.1 Bacteroides intestinalis 642857 643258 NZ_ABJL02000008.1 Bacteroides intestinalis 2029709 2030089 NZ_ABJL02000008.1 Bacteroides intestinalis 1716117 1715746 NZ_ATFI01000002.1 Bacteroides cellulosilyticus 74483 74112 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 122628 123029 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 191727 192140 NZ_CVOY01000058.1 Bacteroides thetaiotaomicron 28964 28593 NZ_DS264541.1 Parabacteroides merdae 67177 66776 NZ_DS362236.1 Bacteroides uniformis 38489 38878 NZ_DS362245.1 Bacteroides uniformis 24062 24184 NZ_DS362245.1 Bacteroides uniformis 24267 24356 NZ_DS362245.1 Bacteroides uniformis 24193 24264 NZ_DS480694.1 Clostridium bolteae 252033 252386 NZ_DS499718.1 Clostridium scindens 309983 309654 NZ_DS995528.1 Bacteroides dorei 127411 127812 NZ_DS995533.1 Bacteroides dorei 131728 131327 NZ_DS996447.1 Parabacteroides johnsonii 92123 91722 NZ_DS996455.1 Parabacteroides johnsonii 41510 41118 NZ_DS996455.1 Parabacteroides johnsonii 41091 40711 NZ_EQ973488.1 Bacteroides cellulosilyticus 155148 154777 NZ_EQ973492.1 Bacteroides cellulosilyticus 200913 200512 NZ_GG657592.1 Clostridium asparagiforme 560671 561042 NZ_GG667665.1 Hungatella hathewayi 3412 3059 NZ_GG688317.1 Bacteroides finegoldii 373129 372716 NZ_GG688317.1 Bacteroides finegoldii 351401 351003 NZ_JGDE01000115.1 Bacteroides fragilis 2024 1617 NZ_JH370371.1 Alistipes indistinctus 1113682 1114062 NZ_JH724297.1 Bacteroides xylanisolvens 171556 171143 NZ_JH724297.1 Bacteroides xylanisolvens 107227 106856 NZ_PUEM01000006.1 Clostridium bolteae 5784734 5784381 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3563261 3562848 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3514703 3514332 NZ_PUEP01000005.1 Bacteroides ovatus 528515 528928 NZ_PUEQ01000002.1 Bacteroides caccae 463991 464404 NZ_PUEQ01000002.1 Bacteroides caccae 521965 522336 NZ_UFTH01000001.1 Bacteroides fragilis 100554 100147 NZ_UFTH01000001.1 Bacteroides fragilis 3470508 3470128 BACDOR_03091 1 254 CVOZ01000016.1 Bacteroides thetaiotaomicron 213809 214567 JGCP01001391.1 Bacteroides fragilis 1827 1213 JGCP01002541.1 Bacteroides fragilis 59029 58271 NC_009614.1 Bacteroides vulgatus 2545071 2545832 NZ_AAVM02000007.1 Bacteroides caccae 240333 241091 NZ_ABJL02000002.1 Bacteroides intestinalis 14878 14120 NZ_ATFI01000018.1 Bacteroides cellulosilyticus 73581 72838 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 107627 108385 NZ_DS264546.1 Parabacteroides merdae 161605 162363 NZ_DS264580.1 Bacteroides ovatus 422161 422919 NZ_DS362242.1 Bacteroides uniformis 128891 128124 NZ_DS499676.1 Bacteroides stercoris 354507 353740 NZ_DS995508.1 Bacteroides eggerthii 374349 375116 NZ_DS995536.1 Bacteroides dorei 46897 46136 NZ_DS996453.1 Parabacteroides johnsonii 310455 311213 NZ_EQ973489.1 Bacteroides cellulosilyticus 471401 472159 NZ_EQ973643.1 Bacteroides coprophilus 27626 28387 NZ_GG688318.1 Bacteroides finegoldii 85948 85178 NZ_GG688321.1 Bacteroides finegoldii 185788 185030 NZ_JGDE01000131.1 Bacteroides fragilis 10637 9879 NZ_JH370372.1 Alistipes indistinctus 247942 248700 NZ_JH724296.1 Bacteroides xylanisolvens 113928 113170 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 447878 448636 NZ_PUEP01000015.1 Bacteroides ovatus 275761 276519 NZ_PUEQ01000003.1 Bacteroides caccae 478198 478956 NZ_UFTH01000001.1 Bacteroides fragilis 906258 905500 CVOZ01000011.1 Bacteroides thetaiotaomicron 219980 219420 CVOZ01000016.1 Bacteroides thetaiotaomicron 167582 167028 CVOZ01000025.1 Bacteroides thetaiotaomicron 66610 66056 CVOZ01000044.1 Bacteroides thetaiotaomicron 108057 107521 CVOZ01000063.1 Bacteroides thetaiotaomicron 143061 143615 CVOZ01000063.1 Bacteroides thetaiotaomicron 145810 146208 JGCP01000973.1 Bacteroides fragilis 643 92 JGCP01001566.1 Bacteroides fragilis 1249 839 JGCP01002360.1 Bacteroides fragilis 23022 22462 JGCP01002412.1 Bacteroides fragilis 4210 3653 JGCP01002443.1 Bacteroides fragilis 42592 42056 JGCP01002542.1 Bacteroides fragilis 18080 18631 JGCP01002566.1 Bacteroides fragilis 42801 43268 NC_009614.1 Bacteroides vulgatus 3183720 3184280 NC_009614.1 Bacteroides vulgatus 499623 499123 NC_009614.1 Bacteroides vulgatus 4349638 4350111 NC_009614.1 Bacteroides vulgatus 4776064 4775543 NC_009615.1 Parabacteroides distasonis 4127877 4128401 NC_009615.1 Parabacteroides distasonis 2031801 2032322 NC_009615.1 Parabacteroides distasonis 1603192 1602650 NC_009615.1 Parabacteroides distasonis 682204 682719 NC_009615.1 Parabacteroides distasonis 3533129 3533686 NZ_AAVM02000001.1 Bacteroides caccae 189463 188936 NZ_AAVM02000001.1 Bacteroides caccae 1211906 1212442 NZ_AAVM02000005.1 Bacteroides caccae 151298 151846 NZ_AAVM02000006.1 Bacteroides caccae 287613 287059 NZ_AAVM02000010.1 Bacteroides caccae 85074 85634 NZ_ABJL02000008.1 Bacteroides intestinalis 2132288 2132833 NZ_ABJL02000008.1 Bacteroides intestinalis 2131519 2132073 NZ_ABJL02000008.1 Bacteroides intestinalis 679330 679866 NZ_ATFI01000005.1 Bacteroides cellulosilyticus 230282 230836 NZ_ATFI01000005.1 Bacteroides cellulosilyticus 231097 231633 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 321265 320705 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 160096 160632 NZ_CVOY01000001.1 Bacteroides thetaiotaomicron 79232 78672 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 62072 61518 NZ_CVOY01000030.1 Bacteroides thetaiotaomicron 4322 3768 NZ_CVOY01000035.1 Bacteroides thetaiotaomicron 14717 14181 NZ_CVOY01000058.1 Bacteroides thetaiotaomicron 33237 32683 NZ_CVOY01000058.1 Bacteroides thetaiotaomicron 30488 30090 NZ_DS264546.1 Parabacteroides merdae 78860 79414 NZ_DS264550.1 Parabacteroides merdae 128183 127710 NZ_DS264553.1 Bacteroides ovatus 176225 176785 NZ_DS264580.1 Bacteroides ovatus 123123 122575 NZ_DS264580.1 Bacteroides ovatus 354346 353792 NZ_DS264583.1 Bacteroides ovatus 172043 172597 NZ_DS362220.1 Bacteroides uniformis 32266 32826 NZ_DS362220.1 Bacteroides uniformis 254449 253925 NZ_DS362244.1 Bacteroides uniformis 102221 101685 NZ_DS362249.1 Bacteroides uniformis 419154 418600 NZ_DS362249.1 Bacteroides uniformis 362515 363072 NZ_DS499662.1 Bacteroides stercoris 200073 200540 NZ_DS499670.1 Bacteroides stercoris 42083 41586 NZ_DS499673.1 Bacteroides stercoris 90740 91294 NZ_DS499673.1 Bacteroides stercoris 541813 541277 NZ_DS995510.1 Bacteroides eggerthii 371763 371206 NZ_DS995510.1 Bacteroides eggerthii 628791 628255 NZ_DS995511.1 Bacteroides eggerthii 217868 218320 NZ_DS995528.1 Bacteroides dorei 122323 122823 NZ_DS995531.1 Bacteroides dorei 766509 767030 NZ_DS995537.1 Bacteroides dorei 622118 622678 NZ_DS995537.1 Bacteroides dorei 760012 760485 NZ_DS996445.1 Parabacteroides johnsonii 218590 219132 NZ_DS996453.1 Parabacteroides johnsonii 227358 227912 NZ_EQ973491.1 Bacteroides cellulosilyticus 1248851 1248297 NZ_EQ973491.1 Bacteroides cellulosilyticus 1248036 1247500 NZ_EQ973492.1 Bacteroides cellulosilyticus 842623 842063 NZ_EQ973492.1 Bacteroides cellulosilyticus 135050 134514 NZ_EQ973635.1 Bacteroides coprophilus 258217 257702 NZ_EQ973643.1 Bacteroides coprophilus 609437 609997 NZ_EQ973643.1 Bacteroides coprophilus 520140 520700 NZ_GG688324.1 Bacteroides finegoldii 201991 201455 NZ_GG688326.1 Bacteroides finegoldii 160158 160718 NZ_GG703852.1 Prevotella copri 780182 779757 NZ_JGDE01000045.1 Bacteroides fragilis 38908 38351 NZ_JGDE01000073.1 Bacteroides fragilis 41461 40925 NZ_JGDE01000133.1 Bacteroides fragilis 26430 26981 NZ_JGDE01000148.1 Bacteroides fragilis 50583 51050 NZ_JH724294.1 Bacteroides xylanisolvens 2266949 2266389 NZ_JH724294.1 Bacteroides xylanisolvens 1638830 1638294 NZ_JH724296.1 Bacteroides xylanisolvens 516372 516920 NZ_JH724296.1 Bacteroides xylanisolvens 205601 206155 NZ_JH724297.1 Bacteroides xylanisolvens 108883 108359 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 85768 85208 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 401651 401097 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3707772 3708326 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3518976 3518422 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3337890 3338426 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3516227 3515829 NZ_PUEP01000005.1 Bacteroides ovatus 1141525 1142085 NZ_PUEP01000005.1 Bacteroides ovatus 332723 332169 NZ_PUEP01000005.1 Bacteroides ovatus 5888755 5888207 NZ_PUEP01000005.1 Bacteroides ovatus 1851269 1851805 NZ_PUEP01000015.1 Bacteroides ovatus 207946 207392 NZ_PUEQ01000002.1 Bacteroides caccae 334672 334118 NZ_PUEQ01000002.1 Bacteroides caccae 518182 518730 NZ_PUEQ01000003.1 Bacteroides caccae 2119824 2119264 NZ_PUEQ01000003.1 Bacteroides caccae 3811487 3810960 NZ_PUEQ01000003.1 Bacteroides caccae 1500715 1501251 NZ_UFTH01000001.1 Bacteroides fragilis 2312130 2311570 NZ_UFTH01000001.1 Bacteroides fragilis 1453837 1454397 NZ_UFTH01000001.1 Bacteroides fragilis 986751 987302 NZ_UFTH01000001.1 Bacteroides fragilis 3476837 3476280 NZ_UFTH01000001.1 Bacteroides fragilis 4140659 4140123 NZ_UFTH01000001.1 Bacteroides fragilis 619273 618815 BACDOR_03934 1 383 CVOZ01000011.1 Bacteroides thetaiotaomicron 219307 218162 CVOZ01000025.1 Bacteroides thetaiotaomicron 65950 64922 JGCP01000352.1 Bacteroides fragilis 1001 3 JGCP01002360.1 Bacteroides fragilis 22362 21214 NC_009614.1 Bacteroides vulgatus 3184401 3185549 NC_009615.1 Parabacteroides distasonis 4010282 4011415 NC_010655.1 Akkermansia muciniphila 2181548 2180451 NC_010655.1 Akkermansia muciniphila 910779 911906 NZ_AAVM02000006.1 Bacteroides caccae 286955 285927 NZ_AAVM02000010.1 Bacteroides caccae 85750 86895 NZ_ABJL02000007.1 Bacteroides intestinalis 1352596 1353708 NZ_ABJL02000008.1 Bacteroides intestinalis 11440 12579 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 320605 319457 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 433197 432070 NZ_ATFI01000007.1 Bacteroides cellulosilyticus 180818 179655 NZ_CVOY01000001.1 Bacteroides thetaiotaomicron 78559 77414 NZ_CVOY01000013.1 Bacteroides thetaiotaomicron 61412 60384 NZ_DS264546.1 Parabacteroides merdae 79514 80632 NZ_DS264553.1 Bacteroides ovatus 176886 178034 NZ_DS264583.1 Bacteroides ovatus 172705 173733 NZ_DS362220.1 Bacteroides uniformis 32930 34078 NZ_DS362243.1 Bacteroides uniformis 130985 132106 NZ_DS499676.1 Bacteroides stercoris 625044 623935 NZ_DS499676.1 Bacteroides stercoris 38390 37269 NZ_DS995510.1 Bacteroides eggerthii 1115618 1114497 NZ_DS995537.1 Bacteroides dorei 622799 623947 NZ_DS995538.1 Bacteroides dorei 80104 79073 NZ_DS996453.1 Parabacteroides johnsonii 228018 229163 NZ_DS996453.1 Parabacteroides johnsonii 441885 442970 NZ_EQ973492.1 Bacteroides cellulosilyticus 841963 840815 NZ_EQ973492.1 Bacteroides cellulosilyticus 701350 700187 NZ_EQ973543.1 Bacteroides cellulosilyticus 698 3 NZ_EQ973643.1 Bacteroides coprophilus 523657 524796 NZ_GG688326.1 Bacteroides finegoldii 160819 161967 NZ_JH370372.1 Alistipes indistinctus 793551 792436 NZ_JH724294.1 Bacteroides xylanisolvens 2266288 2265140 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 85095 83950 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3708432 3709460 NZ_PUEP01000005.1 Bacteroides ovatus 1142186 1143334 NZ_PUEP01000005.1 Bacteroides ovatus 332061 331033 NZ_PUEQ01000002.1 Bacteroides caccae 334014 332986 NZ_PUEQ01000003.1 Bacteroides caccae 2119148 2118003 NZ_UFTH01000001.1 Bacteroides fragilis 2311470 2310322 BACDOR_03379 1 283 BT_4075 177 231 BT_4096 6 227 COLAER_00815 98 240 CVOZ01000004.1 Bacteroides thetaiotaomicron 1448 2302 CVOZ01000011.1 Bacteroides thetaiotaomicron 76210 77025 JGCP01002268.1 Bacteroides fragilis 1309 668 NC_009614.1 Bacteroides vulgatus 2618474 2619322 NZ_AAVM02000002.1 Bacteroides caccae 22009 21158 NZ_CVOY01000037.1 Bacteroides thetaiotaomicron 89304 90158 NZ_DS264554.1 Bacteroides ovatus 556147 555293 NZ_DS995537.1 Bacteroides dorei 24054 24902 NZ_DS996456.1 Parabacteroides johnsonii 449191 448439 NZ_JH724295.1 Bacteroides xylanisolvens 331849 330995 NZ_JH724300.1 Bacteroides xylanisolvens 14748 13909 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 699564 698710 NZ_PUEP01000005.1 Bacteroides ovatus 5040181 5041035 NZ_PUEQ01000003.1 Bacteroides caccae 3599902 3600753 BT_1192 73 143 CVOZ01000002.1 Bacteroides thetaiotaomicron 8661 7258 JGCP01000335.1 Bacteroides fragilis 8259 9164 JGCP01001024.1 Bacteroides fragilis 1280 3 JGCP01001257.1 Bacteroides fragilis 120 1442 JGCP01002379.1 Bacteroides fragilis 49119 48214 NC_009614.1 Bacteroides vulgatus 2668633 2669520 NC_009615.1 Parabacteroides distasonis 249678 250460 NZ_AAVM02000002.1 Bacteroides caccae 123305 124627 NZ_ABJL02000008.1 Bacteroides intestinalis 1704766 1706073 NZ_ABJL02000008.1 Bacteroides intestinalis 2748789 2747893 NZ_ACCL02000002.1 Marvinbryantia formatexigens 191124 192041 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 85812 84916 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 36384 35062 NZ_DS264579.1 Bacteroides ovatus 280554 281876 NZ_DS362220.1 Bacteroides uniformis 135151 134237 NZ_DS499676.1 Bacteroides stercoris 263901 264647 NZ_DS995508.1 Bacteroides eggerthii 458353 457493 NZ_DS995537.1 Bacteroides dorei 83077 83964 NZ_DS996455.1 Parabacteroides johnsonii 32570 31281 NZ_DS996841.1 Holdemanella biformis 28041 27679 NZ_EQ973491.1 Bacteroides cellulosilyticus 494795 495691 NZ_EQ973651.1 Bacteroides coprophilus 164919 166163 NZ_GG657587.1 Clostridium asparagiforme 221025 221390 NZ_GG692736.1 Roseburia intestinalis 18048 17698 NZ_JGDE01000029.1 Bacteroides fragilis 59138 58233 NZ_JH370371.1 Alistipes indistinctus 1369167 1369943 NZ_JH370371.1 Alistipes indistinctus 1341685 1342116 NZ_JH724295.1 Bacteroides xylanisolvens 574839 576158 NZ_JH724295.1 Bacteroides xylanisolvens 582861 584183 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 928679 930082 NZ_PUEP01000005.1 Bacteroides ovatus 4741344 4740022 NZ_PUEQ01000003.1 Bacteroides caccae 3498606 3497284 NZ_UFTH01000001.1 Bacteroides fragilis 2926029 2925124 BACDOR_03642 180 274 BT_4091 419 654 BT_4091 5 222 CVOZ01000011.1 Bacteroides thetaiotaomicron 74671 76059 CVOZ01000011.1 Bacteroides thetaiotaomicron 33113 34528 CVOZ01000021.1 Bacteroides thetaiotaomicron 107438 108184 CVOZ01000021.1 Bacteroides thetaiotaomicron 106535 107161 CVOZ01000033.1 Bacteroides thetaiotaomicron 69509 68802 CVOZ01000033.1 Bacteroides thetaiotaomicron 70706 70098 CVOZ01000041.1 Bacteroides thetaiotaomicron 304006 305376 CVOZ01000043.1 Bacteroides thetaiotaomicron 114574 116010 CVOZ01000043.1 Bacteroides thetaiotaomicron 64290 65657 CVOZ01000043.1 Bacteroides thetaiotaomicron 101489 102028 CVOZ01000043.1 Bacteroides thetaiotaomicron 102635 103321 CVOZ01000044.1 Bacteroides thetaiotaomicron 30432 31790 CVOZ01000044.1 Bacteroides thetaiotaomicron 11573 12922 CVOZ01000044.1 Bacteroides thetaiotaomicron 54744 56120 CVOZ01000045.1 Bacteroides thetaiotaomicron 113209 114579 JGCP01000263.1 Bacteroides fragilis 828 1 JGCP01000476.1 Bacteroides fragilis 1146 52 JGCP01001016.1 Bacteroides fragilis 5 166 JGCP01001396.1 Bacteroides fragilis 664 2091 JGCP01001637.1 Bacteroides fragilis 489 19 JGCP01001863.1 Bacteroides fragilis 2422 1022 JGCP01002441.1 Bacteroides fragilis 11079 12482 JGCP01002533.1 Bacteroides fragilis 3492 4082 JGCP01002533.1 Bacteroides fragilis 4677 5375 NC_008618.1 Bifidobacterium adolescentis 113104 114804 NC_008618.1 Bifidobacterium adolescentis 1901066 1902565 NC_008618.1 Bifidobacterium adolescentis 539816 540412 NC_008618.1 Bifidobacterium adolescentis 541031 541483 NC_009614.1 Bacteroides vulgatus 3437190 3438560 NC_009614.1 Bacteroides vulgatus 5099014 5097611 NC_009614.1 Bacteroides vulgatus 1019138 1018545 NC_009614.1 Bacteroides vulgatus 1017941 1017240 NC_009614.1 Bacteroides vulgatus 4737637 4738329 NC_009614.1 Bacteroides vulgatus 4736464 4737261 NC_009614.1 Bacteroides vulgatus 34966 34268 NC_009614.1 Bacteroides vulgatus 36130 35552 NC_009615.1 Parabacteroides distasonis 58665 57307 NC_009615.1 Parabacteroides distasonis 3530017 3531420 NC_010655.1 Akkermansia muciniphila 541896 543332 NZ_AAVM02000001.1 Bacteroides caccae 1239561 1238158 NZ_AAVM02000005.1 Bacteroides caccae 56513 57871 NZ_ABJL02000002.1 Bacteroides intestinalis 240119 238749 NZ_ABJL02000006.1 Bacteroides intestinalis 172382 172182 NZ_ABJL02000007.1 Bacteroides intestinalis 719924 721378 NZ_ABJL02000007.1 Bacteroides intestinalis 507938 508528 NZ_ABJL02000007.1 Bacteroides intestinalis 509108 509818 NZ_ABJL02000008.1 Bacteroides intestinalis 3173906 3175297 NZ_ABJL02000008.1 Bacteroides intestinalis 3169283 3167952 NZ_ABJL02000008.1 Bacteroides intestinalis 944085 945464 NZ_ABJL02000008.1 Bacteroides intestinalis 2525240 2524545 NZ_ABJL02000008.1 Bacteroides intestinalis 2526407 2525829 NZ_ABJL02000008.1 Bacteroides intestinalis 2484193 2484876 NZ_ABJL02000008.1 Bacteroides intestinalis 2485399 2485773 NZ_ACCL02000028.1 Marvinbryantia formatexigens 17836 18624 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1754879 1755607 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 716683 715988 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 717868 717170 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 340148 339480 NZ_DS995537.1 Bacteroides dorei 622799 623947 NZ_DS995538.1 Bacteroides dorei 80104 79073 NZ_DS996453.1 Parabacteroides johnsonii 228018 229163 NZ_DS996453.1 Parabacteroides johnsonii 441885 442970 NZ_EQ973492.1 Bacteroides cellulosilyticus 841963 840815 NZ_EQ973492.1 Bacteroides cellulosilyticus 701350 700187 NZ_EQ973543.1 Bacteroides cellulosilyticus 698 3 NZ_EQ973643.1 Bacteroides coprophilus 523657 524796 NZ_GG688326.1 Bacteroides finegoldii 160819 161967 NZ_JH370372.1 Alistipes indistinctus 793551 792436 NZ_JH724294.1 Bacteroides xylanisolvens 2266288 2265140 NZ_PUEO01000011.1 Bacteroides thetaiotaomicron 85095 83950 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3708432 3709460 NZ_PUEP01000005.1 Bacteroides ovatus 1142186 1143334 NZ_PUEP01000005.1 Bacteroides ovatus 332061 331033 NZ_PUEQ01000002.1 Bacteroides caccae 334014 332986 NZ_PUEQ01000003.1 Bacteroides caccae 2119148 2118003 NZ_UFTH01000001.1 Bacteroides fragilis 2311470 2310322 BACDOR_03379 1 283 BT_4075 177 231 BT_4096 6 227 COLAER_00815 98 240 CVOZ01000004.1 Bacteroides thetaiotaomicron 1448 2302 CVOZ01000011.1 Bacteroides thetaiotaomicron 76210 77025 JGCP01002268.1 Bacteroides fragilis 1309 668 NC_009614.1 Bacteroides vulgatus 2618474 2619322 NZ_AAVM02000002.1 Bacteroides caccae 22009 21158 NZ_CVOY01000037.1 Bacteroides thetaiotaomicron 89304 90158 NZ_DS264554.1 Bacteroides ovatus 556147 555293 NZ_DS995537.1 Bacteroides dorei 24054 24902 NZ_DS996456.1 Parabacteroides johnsonii 449191 448439 NZ_JH724295.1 Bacteroides xylanisolvens 331849 330995 NZ_JH724300.1 Bacteroides xylanisolvens 14748 13909 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 699564 698710 NZ_PUEP01000005.1 Bacteroides ovatus 5040181 5041035 NZ_PUEQ01000003.1 Bacteroides caccae 3599902 3600753 BT_1192 73 143 CVOZ01000002.1 Bacteroides thetaiotaomicron 8661 7258 JGCP01000335.1 Bacteroides fragilis 8259 9164 JGCP01001024.1 Bacteroides fragilis 1280 3 JGCP01001257.1 Bacteroides fragilis 120 1442 JGCP01002379.1 Bacteroides fragilis 49119 48214 NC_009614.1 Bacteroides vulgatus 2668633 2669520 NC_009615.1 Parabacteroides distasonis 249678 250460 NZ_AAVM02000002.1 Bacteroides caccae 123305 124627 NZ_ABJL02000008.1 Bacteroides intestinalis 1704766 1706073 NZ_ABJL02000008.1 Bacteroides intestinalis 2748789 2747893 NZ_ACCL02000002.1 Marvinbryantia formatexigens 191124 192041 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 85812 84916 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 36384 35062 NZ_DS264579.1 Bacteroides ovatus 280554 281876 NZ_DS362220.1 Bacteroides uniformis 135151 134237 NZ_DS499676.1 Bacteroides stercoris 263901 264647 NZ_DS995508.1 Bacteroides eggerthii 458353 457493 NZ_DS995537.1 Bacteroides dorei 83077 83964 NZ_DS996455.1 Parabacteroides johnsonii 32570 31281 NZ_DS996841.1 Holdemanella biformis 28041 27679 NZ_EQ973491.1 Bacteroides cellulosilyticus 494795 495691 NZ_EQ973651.1 Bacteroides coprophilus 164919 166163 NZ_GG657587.1 Clostridium asparagiforme 221025 221390 NZ_GG692736.1 Roseburia intestinalis 18048 17698 NZ_JGDE01000029.1 Bacteroides fragilis 59138 58233 NZ_JH370371.1 Alistipes indistinctus 1369167 1369943 NZ_JH370371.1 Alistipes indistinctus 1341685 1342116 NZ_JH724295.1 Bacteroides xylanisolvens 574839 576158 NZ_JH724295.1 Bacteroides xylanisolvens 582861 584183 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 928679 930082 NZ_PUEP01000005.1 Bacteroides ovatus 4741344 4740022 NZ_PUEQ01000003.1 Bacteroides caccae 3498606 3497284 NZ_UFTH01000001.1 Bacteroides fragilis 2926029 2925124 BACDOR_03642 180 274 BT_4091 419 654 BT_4091 5 222 CVOZ01000011.1 Bacteroides thetaiotaomicron 74671 76059 CVOZ01000011.1 Bacteroides thetaiotaomicron 33113 34528 CVOZ01000021.1 Bacteroides thetaiotaomicron 107438 108184 CVOZ01000021.1 Bacteroides thetaiotaomicron 106535 107161 CVOZ01000033.1 Bacteroides thetaiotaomicron 69509 68802 CVOZ01000033.1 Bacteroides thetaiotaomicron 70706 70098 CVOZ01000041.1 Bacteroides thetaiotaomicron 304006 305376 CVOZ01000043.1 Bacteroides thetaiotaomicron 114574 116010 CVOZ01000043.1 Bacteroides thetaiotaomicron 64290 65657 CVOZ01000043.1 Bacteroides thetaiotaomicron 101489 102028 CVOZ01000043.1 Bacteroides thetaiotaomicron 102635 103321 CVOZ01000044.1 Bacteroides thetaiotaomicron 30432 31790 CVOZ01000044.1 Bacteroides thetaiotaomicron 11573 12922 CVOZ01000044.1 Bacteroides thetaiotaomicron 54744 56120 CVOZ01000045.1 Bacteroides thetaiotaomicron 113209 114579 JGCP01000263.1 Bacteroides fragilis 828 1 JGCP01000476.1 Bacteroides fragilis 1146 52 JGCP01001016.1 Bacteroides fragilis 5 166 JGCP01001396.1 Bacteroides fragilis 664 2091 JGCP01001637.1 Bacteroides fragilis 489 19 JGCP01001863.1 Bacteroides fragilis 2422 1022 JGCP01002441.1 Bacteroides fragilis 11079 12482 JGCP01002533.1 Bacteroides fragilis 3492 4082 JGCP01002533.1 Bacteroides fragilis 4677 5375 NC_008618.1 Bifidobacterium adolescentis 113104 114804 NC_008618.1 Bifidobacterium adolescentis 1901066 1902565 NC_008618.1 Bifidobacterium adolescentis 539816 540412 NC_008618.1 Bifidobacterium adolescentis 541031 541483 NC_009614.1 Bacteroides vulgatus 3437190 3438560 NC_009614.1 Bacteroides vulgatus 5099014 5097611 NC_009614.1 Bacteroides vulgatus 1019138 1018545 NC_009614.1 Bacteroides vulgatus 1017941 1017240 NC_009614.1 Bacteroides vulgatus 4737637 4738329 NC_009614.1 Bacteroides vulgatus 4736464 4737261 NC_009614.1 Bacteroides vulgatus 34966 34268 NC_009614.1 Bacteroides vulgatus 36130 35552 NC_009615.1 Parabacteroides distasonis 58665 57307 NC_009615.1 Parabacteroides distasonis 3530017 3531420 NC_010655.1 Akkermansia muciniphila 541896 543332 NZ_AAVM02000001.1 Bacteroides caccae 1239561 1238158 NZ_AAVM02000005.1 Bacteroides caccae 56513 57871 NZ_ABJL02000002.1 Bacteroides intestinalis 240119 238749 NZ_ABJL02000006.1 Bacteroides intestinalis 172382 172182 NZ_ABJL02000007.1 Bacteroides intestinalis 719924 721378 NZ_ABJL02000007.1 Bacteroides intestinalis 507938 508528 NZ_ABJL02000007.1 Bacteroides intestinalis 509108 509818 NZ_ABJL02000008.1 Bacteroides intestinalis 3173906 3175297 NZ_ABJL02000008.1 Bacteroides intestinalis 3169283 3167952 NZ_ABJL02000008.1 Bacteroides intestinalis 944085 945464 NZ_ABJL02000008.1 Bacteroides intestinalis 2525240 2524545 NZ_ABJL02000008.1 Bacteroides intestinalis 2526407 2525829 NZ_ABJL02000008.1 Bacteroides intestinalis 2484193 2484876 NZ_ABJL02000008.1 Bacteroides intestinalis 2485399 2485773 NZ_ACCL02000028.1 Marvinbryantia formatexigens 17836 18624 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1754879 1755607 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 716683 715988 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 717868 717170 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 340148 339480 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1753760 1754329 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 341297 340749 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 667727 669118 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 665971 664640 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 634679 636016 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 636101 637438 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 748203 746851 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 344620 343925 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 345787 345209 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 291205 291885 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 292408 292782 NZ_ATFI01000010.1 Bacteroides cellulosilyticus 116498 115128 NZ_ATFI01000013.1 Bacteroides cellulosilyticus 166257 164884 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 2896 3603 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 1699 2307 NZ_CVOY01000015.1 Bacteroides thetaiotaomicron 29835 31205 NZ_CVOY01000028.1 Bacteroides thetaiotaomicron 92641 94011 NZ_CVOY01000029.1 Bacteroides thetaiotaomicron 122519 123865 NZ_CVOY01000041.1 Bacteroides thetaiotaomicron 66500 65124 NZ_CVOY01000043.1 Bacteroides thetaiotaomicron 51552 52919 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 19916 21352 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 6767 7363 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 7970 8656 NZ_CVOY01000089.1 Bacteroides thetaiotaomicron 11279 12025 NZ_CVOY01000089.1 Bacteroides thetaiotaomicron 10376 11002 NZ_CVOY01000094.1 Bacteroides thetaiotaomicron 1 846 NZ_CVOY01000102.1 Bacteroides thetaiotaomicron 4048 2699 NZ_CVOY01000120.1 Bacteroides thetaiotaomicron 2031 2558 NZ_DS264461.1 Parabacteroides merdae 326679 328088 NZ_DS264553.1 Bacteroides ovatus 485184 483814 NZ_DS264563.1 Bacteroides ovatus 240601 239249 NZ_DS264563.1 Bacteroides ovatus 230088 231446 NZ_DS264579.1 Bacteroides ovatus 190274 188934 NZ_DS264579.1 Bacteroides ovatus 345939 344572 NZ_DS264579.1 Bacteroides ovatus 26411 27115 NZ_DS264579.1 Bacteroides ovatus 25214 25867 NZ_DS264581.1 Bacteroides ovatus 193952 193377 NZ_DS264581.1 Bacteroides ovatus 192791 192096 NZ_DS264583.1 Bacteroides ovatus 293997 293422 NZ_DS264583.1 Bacteroides ovatus 292812 292450 NZ_DS264584.1 Bacteroides ovatus 458625 459983 NZ_DS362248.1 Bacteroides uniformis 463612 462248 NZ_DS362248.1 Bacteroides uniformis 44198 45535 NZ_DS499654.1 Erysipelatoclostridium ramosum 458831 460294 NZ_DS499669.1 Bacteroides stercoris 56028 54667 NZ_DS499673.1 Bacteroides stercoris 494276 495676 NZ_DS995509.1 Bacteroides eggerthii 43221 44582 NZ_DS995509.1 Bacteroides eggerthii 775569 776297 NZ_DS995509.1 Bacteroides eggerthii 772156 771578 NZ_DS995509.1 Bacteroides eggerthii 774495 775103 NZ_DS995509.1 Bacteroides eggerthii 770989 770606 NZ_DS995510.1 Bacteroides eggerthii 502400 501018 NZ_DS995510.1 Bacteroides eggerthii 528488 529825 NZ_DS995510.1 Bacteroides eggerthii 204435 205853 NZ_DS995511.1 Bacteroides eggerthii 320527 319190 NZ_DS995511.1 Bacteroides eggerthii 378660 377212 NZ_DS995511.1 Bacteroides eggerthii 445669 444224 NZ_DS995531.1 Bacteroides dorei 371558 372925 NZ_DS995531.1 Bacteroides dorei 449132 450535 NZ_DS995531.1 Bacteroides dorei 312254 312832 NZ_DS995531.1 Bacteroides dorei 313421 314116 NZ_DS995533.1 Bacteroides dorei 1775 1083 NZ_DS995533.1 Bacteroides dorei 2948 2379 NZ_DS995537.1 Bacteroides dorei 920220 921590 NZ_DS995538.1 Bacteroides dorei 45726 45025 NZ_DS995538.1 Bacteroides dorei 46932 46330 NZ_DS996444.1 Parabacteroides johnsonii 535363 536772 NZ_DS996444.1 Parabacteroides johnsonii 269736 269134 NZ_DS996444.1 Parabacteroides johnsonii 268632 268198 NZ_EQ973486.1 Bacteroides cellulosilyticus 124072 122681 NZ_EQ973486.1 Bacteroides cellulosilyticus 126082 127413 NZ_EQ973486.1 Bacteroides cellulosilyticus 157708 156371 NZ_EQ973486.1 Bacteroides cellulosilyticus 156286 154949 NZ_EQ973486.1 Bacteroides cellulosilyticus 42916 44025 NZ_EQ973486.1 Bacteroides cellulosilyticus 43994 44269 NZ_EQ973490.1 Bacteroides cellulosilyticus 50726 49353 NZ_EQ973490.1 Bacteroides cellulosilyticus 1964751 1965479 NZ_EQ973490.1 Bacteroides cellulosilyticus 811729 811031 NZ_EQ973490.1 Bacteroides cellulosilyticus 445831 445163 NZ_EQ973490.1 Bacteroides cellulosilyticus 810544 810017 NZ_EQ973490.1 Bacteroides cellulosilyticus 1963632 1964201 NZ_EQ973490.1 Bacteroides cellulosilyticus 446980 446432 NZ_EQ973491.1 Bacteroides cellulosilyticus 107522 108793 NZ_EQ973491.1 Bacteroides cellulosilyticus 756794 757489 NZ_EQ973491.1 Bacteroides cellulosilyticus 755627 756205 NZ_EQ973491.1 Bacteroides cellulosilyticus 811215 810535 NZ_EQ973491.1 Bacteroides cellulosilyticus 810012 809638 NZ_EQ973495.1 Bacteroides cellulosilyticus 70783 72162 NZ_EQ973645.1 Bacteroides coprophilus 64693 66096 NZ_GG667711.1 Hungatella hathewayi 24610 23903 NZ_GG667711.1 Hungatella hathewayi 25807 25196 NZ_GG688320.1 Bacteroides finegoldii 174406 173048 NZ_GG688323.1 Bacteroides finegoldii 51406 50036 NZ_GG688332.1 Bacteroides finegoldii 82694 82395 NZ_GG703863.1 Prevotella copri 25172 26572 NZ_JGDE01000072.1 Bacteroides fragilis 10558 11961 NZ_JGDE01000126.1 Bacteroides fragilis 27194 27784 NZ_JGDE01000126.1 Bacteroides fragilis 28379 29077 NZ_JH724294.1 Bacteroides xylanisolvens 1911484 1912854 NZ_JH724294.1 Bacteroides xylanisolvens 1590639 1589281 NZ_JH724294.1 Bacteroides xylanisolvens 361730 362440 NZ_JH724294.1 Bacteroides xylanisolvens 360536 361126 NZ_JH724295.1 Bacteroides xylanisolvens 1623208 1624584 NZ_JH724295.1 Bacteroides xylanisolvens 661738 660371 NZ_JH724296.1 Bacteroides xylanisolvens 499153 497783 NZ_JH724296.1 Bacteroides xylanisolvens 239797 241236 NZ_JH724298.1 Bacteroides xylanisolvens 184281 184970 NZ_JH724298.1 Bacteroides xylanisolvens 185469 185849 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 951107 949671 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1015372 1014005 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 964257 963661 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 963054 962368 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2339682 2341040 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3014588 3013218 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 184534 183164 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2364015 2365391 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 868998 869705 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 4023284 4022538 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 867801 868409 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 4024187 4023561 NZ_PUEP01000005.1 Bacteroides ovatus 4831625 4832965 NZ_PUEP01000005.1 Bacteroides ovatus 1909400 1910752 NZ_PUEP01000005.1 Bacteroides ovatus 1450439 1449069 NZ_PUEP01000005.1 Bacteroides ovatus 1919913 1918555 NZ_PUEP01000005.1 Bacteroides ovatus 4675959 4677326 NZ_PUEP01000005.1 Bacteroides ovatus 2987124 2985766 NZ_PUEP01000005.1 Bacteroides ovatus 4995491 4994787 NZ_PUEP01000005.1 Bacteroides ovatus 4996688 4996035 NZ_PUEP01000005.1 Bacteroides ovatus 210770 211345 NZ_PUEP01000005.1 Bacteroides ovatus 3955317 3955892 NZ_PUEP01000005.1 Bacteroides ovatus 3956478 3957173 NZ_PUEP01000005.1 Bacteroides ovatus 211955 212317 NZ_PUEQ01000002.1 Bacteroides caccae 423398 424756 NZ_PUEQ01000003.1 Bacteroides caccae 1528370 1526967 NZ_UFTH01000001.1 Bacteroides fragilis 4051853 4053256 NZ_UFTH01000001.1 Bacteroides fragilis 634929 635519 NZ_UFTH01000001.1 Bacteroides fragilis 636114 636812 QEKH01000001.1 Victivallis vadensis 296578 297354 QEKH01000001.1 Victivallis vadensis 259902 259210 QEKH01000001.1 Victivallis vadensis 295345 295962 QEKH01000001.1 Victivallis vadensis 261147 260575 QEKH01000003.1 Victivallis vadensis 120748 122115 QEKH01000011.1 Victivallis vadensis 39979 38537 QEKH01000018.1 Victivallis vadensis 24528 23029 QEKH01000033.1 Victivallis vadensis 47019 45649 QEKH01000042.1 Victivallis vadensis 3416 4150 QEKH01000042.1 Victivallis vadensis 2183 2791 BACDOR_00665 45 104 BACDOR_03379 212 273 BT_0569 40 231 BT_2961 214 271 BT_4096 3 460 CVOZ01000033.1 Bacteroides thetaiotaomicron 99605 98205 CVOZ01000033.1 Bacteroides thetaiotaomicron 61396 60014 NC_009615.1 Parabacteroides distasonis 264706 266067 NC_009615.1 Parabacteroides distasonis 3795050 3796402 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 11010 12392 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 27423 26023 NZ_DS264584.1 Bacteroides ovatus 251782 253182 NZ_DS264584.1 Bacteroides ovatus 279314 280687 NZ_JH724294.1 Bacteroides xylanisolvens 336113 337513 NZ_JH724294.1 Bacteroides xylanisolvens 368251 369624 NZ_JH724294.1 Bacteroides xylanisolvens 357519 358895 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 838901 840301 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 877110 878492 NZ_PUEP01000005.1 Bacteroides ovatus 3193968 3192568 NZ_PUEP01000005.1 Bacteroides ovatus 3166436 3165063 QEKH01000001.1 Victivallis vadensis 132621 131368 QEKH01000002.1 Victivallis vadensis 100395 99751 QEKH01000021.1 Victivallis vadensis 86373 87041 QEKH01000042.1 Victivallis vadensis 14734 15321 BT_3124 241 479 BT_3124 3 228 CVOZ01000011.1 Bacteroides thetaiotaomicron 74620 75276 CVOZ01000011.1 Bacteroides thetaiotaomicron 33827 34531 CVOZ01000011.1 Bacteroides thetaiotaomicron 75238 76062 CVOZ01000011.1 Bacteroides thetaiotaomicron 33134 33793 CVOZ01000021.1 Bacteroides thetaiotaomicron 107432 108184 CVOZ01000021.1 Bacteroides thetaiotaomicron 106475 107299 CVOZ01000033.1 Bacteroides thetaiotaomicron 70763 68778 CVOZ01000041.1 Bacteroides thetaiotaomicron 303958 304608 CVOZ01000041.1 Bacteroides thetaiotaomicron 304672 305376 CVOZ01000043.1 Bacteroides thetaiotaomicron 101498 103327 CVOZ01000043.1 Bacteroides thetaiotaomicron 115294 116010 CVOZ01000043.1 Bacteroides thetaiotaomicron 64239 64898 CVOZ01000043.1 Bacteroides thetaiotaomicron 114580 115257 CVOZ01000043.1 Bacteroides thetaiotaomicron 64962 65666 CVOZ01000044.1 Bacteroides thetaiotaomicron 11540 12187 CVOZ01000044.1 Bacteroides thetaiotaomicron 30408 31103 CVOZ01000044.1 Bacteroides thetaiotaomicron 31080 31790 CVOZ01000044.1 Bacteroides thetaiotaomicron 55437 56120 CVOZ01000044.1 Bacteroides thetaiotaomicron 12212 12922 CVOZ01000044.1 Bacteroides thetaiotaomicron 54720 55550 CVOZ01000045.1 Bacteroides thetaiotaomicron 113179 113826 CVOZ01000045.1 Bacteroides thetaiotaomicron 113845 114579 JGCP01000263.1 Bacteroides fragilis 858 211 JGCP01000263.1 Bacteroides fragilis 171 1 JGCP01000476.1 Bacteroides fragilis 900 43 JGCP01000476.1 Bacteroides fragilis 1149 802 JGCP01001016.1 Bacteroides fragilis 8 328 JGCP01001396.1 Bacteroides fragilis 1381 2091 JGCP01001396.1 Bacteroides fragilis 664 1266 JGCP01001637.1 Bacteroides fragilis 489 7 JGCP01001863.1 Bacteroides fragilis 1705 1019 JGCP01001863.1 Bacteroides fragilis 2422 1820 JGCP01002441.1 Bacteroides fragilis 11796 12482 JGCP01002441.1 Bacteroides fragilis 11079 11681 JGCP01002533.1 Bacteroides fragilis 3435 5387 NC_008618.1 Bifidobacterium adolescentis 539801 541717 NC_008618.1 Bifidobacterium adolescentis 113920 114804 NC_008618.1 Bifidobacterium adolescentis 113092 114030 NC_008618.1 Bifidobacterium adolescentis 393068 393487 NC_008618.1 Bifidobacterium adolescentis 1901057 1901710 NC_009614.1 Bacteroides vulgatus 1019192 1017240 NC_009614.1 Bacteroides vulgatus 4736413 4738329 NC_009614.1 Bacteroides vulgatus 36139 34268 NC_009614.1 Bacteroides vulgatus 3437145 3437807 NC_009614.1 Bacteroides vulgatus 5098297 5097611 NC_009614.1 Bacteroides vulgatus 3437826 3438560 NC_009614.1 Bacteroides vulgatus 5099014 5098412 NC_009615.1 Parabacteroides distasonis 3530692 3531420 NC_009615.1 Parabacteroides distasonis 58080 57307 NC_009615.1 Parabacteroides distasonis 58722 58066 NC_009615.1 Parabacteroides distasonis 3530017 3530631 NC_010655.1 Akkermansia muciniphila 542610 543332 NC_010655.1 Akkermansia muciniphila 541896 542486 NZ_AAVM02000001.1 Bacteroides caccae 1238844 1238158 NZ_AAVM02000001.1 Bacteroides caccae 1239561 1238959 NZ_AAVM02000005.1 Bacteroides caccae 57149 57871 NZ_AAVM02000005.1 Bacteroides caccae 56462 57106 NZ_ABJL02000002.1 Bacteroides intestinalis 239465 238749 NZ_ABJL02000002.1 Bacteroides intestinalis 240158 239496 NZ_ABJL02000006.1 Bacteroides intestinalis 172436 172182 NZ_ABJL02000007.1 Bacteroides intestinalis 507881 509830 NZ_ABJL02000007.1 Bacteroides intestinalis 720668 721381 NZ_ABJL02000007.1 Bacteroides intestinalis 719873 720490 NZ_ABJL02000008.1 Bacteroides intestinalis 2526443 2524545 NZ_ABJL02000008.1 Bacteroides intestinalis 2484163 2485770 NZ_ABJL02000008.1 Bacteroides intestinalis 944772 945464 NZ_ABJL02000008.1 Bacteroides intestinalis 3168665 3167952 NZ_ABJL02000008.1 Bacteroides intestinalis 3174590 3175297 NZ_ABJL02000008.1 Bacteroides intestinalis 3169325 3168690 NZ_ABJL02000008.1 Bacteroides intestinalis 944064 944690 NZ_ABJL02000008.1 Bacteroides intestinalis 3173903 3174544 NZ_ACCL02000028.1 Marvinbryantia formatexigens 16369 18624 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 717919 715976 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1753709 1755610 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 341321 339480 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 176816 176448 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 665353 664640 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 634622 635347 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 666022 665381 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 635333 636016 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 636062 636697 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 747630 746851 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 668414 669118 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 667739 668365 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 748281 747637 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 636749 637447 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 345823 343925 NZ_ATFI01000009.1 Bacteroides cellulosilyticus 291172 292779 NZ_ATFI01000010.1 Bacteroides cellulosilyticus 116525 115881 NZ_ATFI01000010.1 Bacteroides cellulosilyticus 115862 115128 NZ_ATFI01000013.1 Bacteroides cellulosilyticus 165564 164869 NZ_ATFI01000013.1 Bacteroides cellulosilyticus 166287 165634 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 1642 3627 NZ_CVOY01000015.1 Bacteroides thetaiotaomicron 29805 30452 NZ_CVOY01000015.1 Bacteroides thetaiotaomicron 30471 31205 NZ_CVOY01000028.1 Bacteroides thetaiotaomicron 92593 93243 NZ_CVOY01000028.1 Bacteroides thetaiotaomicron 93307 94011 NZ_CVOY01000029.1 Bacteroides thetaiotaomicron 122462 123130 NZ_CVOY01000029.1 Bacteroides thetaiotaomicron 123170 123865 NZ_CVOY01000041.1 Bacteroides thetaiotaomicron 65807 65124 NZ_CVOY01000041.1 Bacteroides thetaiotaomicron 66524 65694 NZ_CVOY01000043.1 Bacteroides thetaiotaomicron 51501 52160 NZ_CVOY01000043.1 Bacteroides thetaiotaomicron 52224 52928 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 6722 8662 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 20636 21352 NZ_CVOY01000050.1 Bacteroides thetaiotaomicron 19922 20599 NZ_CVOY01000089.1 Bacteroides thetaiotaomicron 11273 12025 NZ_CVOY01000089.1 Bacteroides thetaiotaomicron 10316 11140 NZ_CVOY01000094.1 Bacteroides thetaiotaomicron 136 846 NZ_CVOY01000102.1 Bacteroides thetaiotaomicron 4081 3434 NZ_CVOY01000102.1 Bacteroides thetaiotaomicron 3409 2699 NZ_CVOY01000120.1 Bacteroides thetaiotaomicron 2007 2552 NZ_DS264461.1 Parabacteroides merdae 327354 328088 NZ_DS264461.1 Parabacteroides merdae 326694 327290 NZ_DS264553.1 Bacteroides ovatus 485214 484567 NZ_DS264553.1 Bacteroides ovatus 484548 483814 NZ_DS264563.1 Bacteroides ovatus 230064 230708 NZ_DS264563.1 Bacteroides ovatus 240646 239993 NZ_DS264563.1 Bacteroides ovatus 240010 239249 NZ_DS264563.1 Bacteroides ovatus 230733 231446 NZ_DS264579.1 Bacteroides ovatus 25214 27115 NZ_DS264579.1 Bacteroides ovatus 189683 188934 NZ_DS264579.1 Bacteroides ovatus 345420 344563 NZ_DS264579.1 Bacteroides ovatus 190319 189654 NZ_DS264579.1 Bacteroides ovatus 345930 345322 NZ_DS264581.1 Bacteroides ovatus 194006 192096 NZ_DS264583.1 Bacteroides ovatus 294027 292444 NZ_DS264584.1 Bacteroides ovatus 459309 460004 NZ_DS264584.1 Bacteroides ovatus 458592 459305 NZ_DS264584.1 Bacteroides ovatus 273310 273522 NZ_DS362248.1 Bacteroides uniformis 463033 462248 NZ_DS362248.1 Bacteroides uniformis 463663 463004 NZ_DS362248.1 Bacteroides uniformis 44192 44803 NZ_DS362248.1 Bacteroides uniformis 44831 45532 NZ_DS499654.1 Erysipelatoclostridium ramosum 459551 460294 NZ_DS499654.1 Erysipelatoclostridium ramosum 458840 459829 NZ_DS499669.1 Bacteroides stercoris 55347 54652 NZ_DS499669.1 Bacteroides stercoris 56085 55366 NZ_DS499673.1 Bacteroides stercoris 494828 495712 NZ_DS499673.1 Bacteroides stercoris 494264 494887 NZ_DS995509.1 Bacteroides eggerthii 774444 776297 NZ_DS995509.1 Bacteroides eggerthii 772192 770606 NZ_DS995509.1 Bacteroides eggerthii 43167 43862 NZ_DS995509.1 Bacteroides eggerthii 43842 44582 NZ_DS995510.1 Bacteroides eggerthii 529121 529825 NZ_DS995510.1 Bacteroides eggerthii 501722 501018 NZ_DS995510.1 Bacteroides eggerthii 528449 529084 NZ_DS995510.1 Bacteroides eggerthii 502442 501771 NZ_DS995510.1 Bacteroides eggerthii 205068 205853 NZ_DS995510.1 Bacteroides eggerthii 204429 205115 NZ_DS995511.1 Bacteroides eggerthii 377907 377200 NZ_DS995511.1 Bacteroides eggerthii 444934 444194 NZ_DS995511.1 Bacteroides eggerthii 320605 319916 NZ_DS995511.1 Bacteroides eggerthii 319891 319190 NZ_DS995511.1 Bacteroides eggerthii 445651 445079 NZ_DS995511.1 Bacteroides eggerthii 378660 378064 NZ_DS995531.1 Bacteroides dorei 312233 314116 NZ_DS995531.1 Bacteroides dorei 449795 450535 NZ_DS995531.1 Bacteroides dorei 372209 372925 NZ_DS995531.1 Bacteroides dorei 371504 372148 NZ_DS995531.1 Bacteroides dorei 449132 449734 NZ_DS995533.1 Bacteroides dorei 2999 1083 NZ_DS995537.1 Bacteroides dorei 920175 920837 NZ_DS995537.1 Bacteroides dorei 920856 921590 NZ_DS995538.1 Bacteroides dorei 46977 45025 NZ_DS996444.1 Parabacteroides johnsonii 269793 268207 NZ_DS996444.1 Parabacteroides johnsonii 536038 536772 NZ_DS996444.1 Parabacteroides johnsonii 535381 535974 NZ_EQ973486.1 Bacteroides cellulosilyticus 126700 127413 NZ_EQ973486.1 Bacteroides cellulosilyticus 157765 157040 NZ_EQ973486.1 Bacteroides cellulosilyticus 157054 156371 NZ_EQ973486.1 Bacteroides cellulosilyticus 156325 155690 NZ_EQ973486.1 Bacteroides cellulosilyticus 126031 126672 NZ_EQ973486.1 Bacteroides cellulosilyticus 123385 122681 NZ_EQ973486.1 Bacteroides cellulosilyticus 43489 43956 NZ_EQ973486.1 Bacteroides cellulosilyticus 43994 44269 NZ_EQ973486.1 Bacteroides cellulosilyticus 124060 123434 NZ_EQ973486.1 Bacteroides cellulosilyticus 42838 43482 NZ_EQ973486.1 Bacteroides cellulosilyticus 155638 154940 NZ_EQ973490.1 Bacteroides cellulosilyticus 811780 810014 NZ_EQ973490.1 Bacteroides cellulosilyticus 1963581 1965482 NZ_EQ973490.1 Bacteroides cellulosilyticus 447004 445163 NZ_EQ973490.1 Bacteroides cellulosilyticus 50033 49338 NZ_EQ973490.1 Bacteroides cellulosilyticus 50756 50103 NZ_EQ973490.1 Bacteroides cellulosilyticus 791221 791045 NZ_EQ973490.1 Bacteroides cellulosilyticus 276595 276227 NZ_EQ973491.1 Bacteroides cellulosilyticus 755591 757489 NZ_EQ973491.1 Bacteroides cellulosilyticus 811248 809641 NZ_EQ973491.1 Bacteroides cellulosilyticus 107495 108139 NZ_EQ973491.1 Bacteroides cellulosilyticus 108158 108793 NZ_EQ973495.1 Bacteroides cellulosilyticus 71470 72162 NZ_EQ973495.1 Bacteroides cellulosilyticus 70762 71388 NZ_EQ973645.1 Bacteroides coprophilus 65398 66096 NZ_EQ973645.1 Bacteroides coprophilus 64693 65487 NZ_GG667711.1 Hungatella hathewayi 25792 23903 NZ_GG688320.1 Bacteroides finegoldii 173722 173027 NZ_GG688320.1 Bacteroides finegoldii 174439 173726 NZ_GG688323.1 Bacteroides finegoldii 51433 50789 NZ_GG688323.1 Bacteroides finegoldii 50770 50036 NZ_GG703863.1 Prevotella copri 25121 25768 NZ_GG703863.1 Prevotella copri 25823 26572 NZ_JGDE01000072.1 Bacteroides fragilis 11275 11961 NZ_JGDE01000072.1 Bacteroides fragilis 10558 11160 NZ_JGDE01000126.1 Bacteroides fragilis 27137 29089 NZ_JH724294.1 Bacteroides xylanisolvens 360479 362464 NZ_JH724294.1 Bacteroides xylanisolvens 1911454 1912101 NZ_JH724294.1 Bacteroides xylanisolvens 1590663 1590019 NZ_JH724294.1 Bacteroides xylanisolvens 1912120 1912854 NZ_JH724294.1 Bacteroides xylanisolvens 1589994 1589281 NZ_JH724295.1 Bacteroides xylanisolvens 1623178 1623825 NZ_JH724295.1 Bacteroides xylanisolvens 661219 660362 NZ_JH724295.1 Bacteroides xylanisolvens 661729 661121 NZ_JH724295.1 Bacteroides xylanisolvens 1623793 1624593 NZ_JH724296.1 Bacteroides xylanisolvens 240529 241266 NZ_JH724296.1 Bacteroides xylanisolvens 499186 498554 NZ_JH724296.1 Bacteroides xylanisolvens 498484 497780 NZ_JH724296.1 Bacteroides xylanisolvens 239746 240348 NZ_JH724298.1 Bacteroides xylanisolvens 184254 185849 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 964302 962362 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 950387 949671 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1015423 1014764 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 951101 950424 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1014700 1013996 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 867744 869729 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 4023290 4022538 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3014618 3013971 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3013952 3013218 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2339658 2340353 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2340330 2341040 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 184582 183932 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2364708 2365391 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 183868 183164 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 4024199 4023423 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2363991 2364821 NZ_PUEP01000005.1 Bacteroides ovatus 4996688 4994787 NZ_PUEP01000005.1 Bacteroides ovatus 3955263 3957173 NZ_PUEP01000005.1 Bacteroides ovatus 210740 212323 NZ_PUEP01000005.1 Bacteroides ovatus 2986440 2985745 NZ_PUEP01000005.1 Bacteroides ovatus 1450469 1449822 NZ_PUEP01000005.1 Bacteroides ovatus 4832216 4832965 NZ_PUEP01000005.1 Bacteroides ovatus 1919937 1919293 NZ_PUEP01000005.1 Bacteroides ovatus 1909355 1910008 NZ_PUEP01000005.1 Bacteroides ovatus 1449803 1449069 NZ_PUEP01000005.1 Bacteroides ovatus 2987157 2986444 NZ_PUEP01000005.1 Bacteroides ovatus 1909991 1910752 NZ_PUEP01000005.1 Bacteroides ovatus 1919268 1918555 NZ_PUEP01000005.1 Bacteroides ovatus 4676478 4677335 NZ_PUEP01000005.1 Bacteroides ovatus 4831580 4832245 NZ_PUEP01000005.1 Bacteroides ovatus 4675968 4676576 NZ_PUEP01000005.1 Bacteroides ovatus 3172440 3172228 NZ_PUEQ01000002.1 Bacteroides caccae 424034 424756 NZ_PUEQ01000002.1 Bacteroides caccae 423347 423991 NZ_PUEQ01000003.1 Bacteroides caccae 1527653 1526967 NZ_PUEQ01000003.1 Bacteroides caccae 1528370 1527768 NZ_UFTH01000001.1 Bacteroides fragilis 634872 636824 NZ_UFTH01000001.1 Bacteroides fragilis 4052570 4053256 NZ_UFTH01000001.1 Bacteroides fragilis 4051853 4052455 QEKH01000001.1 Victivallis vadensis 261147 259213 QEKH01000001.1 Victivallis vadensis 295375 297354 QEKH01000001.1 Victivallis vadensis 174465 174815 QEKH01000003.1 Victivallis vadensis 121426 122112 QEKH01000003.1 Victivallis vadensis 120697 121353 QEKH01000005.1 Victivallis vadensis 102693 102322 QEKH01000011.1 Victivallis vadensis 39211 38537 QEKH01000011.1 Victivallis vadensis 39979 39317 QEKH01000017.1 Victivallis vadensis 5676 5230 QEKH01000018.1 Victivallis vadensis 24540 23800 QEKH01000018.1 Victivallis vadensis 23730 23017 QEKH01000026.1 Victivallis vadensis 59633 60028 QEKH01000033.1 Victivallis vadensis 46335 45649 QEKH01000033.1 Victivallis vadensis 47037 46432 QEKH01000042.1 Victivallis vadensis 2180 4150 BACDOR_00665 24 209 BT_0569 39 231 BT_1192 267 452 BT_2961 11 271 BT_4075 8 466 CVOZ01000033.1 Bacteroides thetaiotaomicron 61393 60014 CVOZ01000033.1 Bacteroides thetaiotaomicron 99584 98208 NC_009615.1 Parabacteroides distasonis 3795026 3796402 NC_009615.1 Parabacteroides distasonis 264697 266070 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 11013 12392 NZ_CVOY01000007.1 Bacteroides thetaiotaomicron 27402 26026 NZ_DS264584.1 Bacteroides ovatus 279308 280687 NZ_DS264584.1 Bacteroides ovatus 251803 253182 NZ_DS362240.1 Bacteroides uniformis 192340 193038 NZ_DS996453.1 Parabacteroides johnsonii 23050 22433 NZ_JH724294.1 Bacteroides xylanisolvens 368245 369624 NZ_JH724294.1 Bacteroides xylanisolvens 357525 358895 NZ_JH724294.1 Bacteroides xylanisolvens 336134 337513 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 877113 878492 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 838922 840298 NZ_PUEP01000005.1 Bacteroides ovatus 3166442 3165063 NZ_PUEP01000005.1 Bacteroides ovatus 3193947 3192568 QEKH01000001.1 Victivallis vadensis 132621 131698 QEKH01000001.1 Victivallis vadensis 111338 110643 QEKH01000042.1 Victivallis vadensis 14734 15336 BT_1192 274 391 NZ_AAVN02000001.1 Collinsella aerofaciens 309869 309213 NZ_ACCL02000001.1 Marvinbryantia formatexigens 196740 197378 NZ_ACEP01000075.1 Eubacterium hallii 1967 2593 NZ_DS480699.1 Clostridium bolteae 56611 57216 NZ_DS544183.1 Anaerotruncus colihominis 164934 165578 NZ_DS990202.1 Ruminococcus lactaris 95396 94794 NZ_DS996840.1 Holdemanella biformis 66548 65937 NZ_GG657592.1 Clostridium asparagiforme 526631 526026 NZ_GG662012.1 Coprococcus comes 180676 180056 NZ_GG667621.1 Hungatella hathewayi 56888 57523 NZ_GG692722.1 Roseburia intestinalis 63578 62997 NZ_PUEM01000006.1 Clostridium bolteae 96643 97248 CVOZ01000005.1 Bacteroides thetaiotaomicron 57756 58391 CVOZ01000006.1 Bacteroides thetaiotaomicron 30425 31405 CVOZ01000006.1 Bacteroides thetaiotaomicron 3549 4445 CVOZ01000032.1 Bacteroides thetaiotaomicron 285470 284589 CVOZ01000033.1 Bacteroides thetaiotaomicron 41117 40113 CVOZ01000045.1 Bacteroides thetaiotaomicron 65855 64761 JGCP01000292.1 Bacteroides fragilis 188 1129 JGCP01000923.1 Bacteroides fragilis 469 2 JGCP01001315.1 Bacteroides fragilis 1656 1096 JGCP01001936.1 Bacteroides fragilis 2158 2640 NC_009614.1 Bacteroides vulgatus 3354933 3356018 NC_009614.1 Bacteroides vulgatus 2447171 2446089 NC_009614.1 Bacteroides vulgatus 2316235 2317242 NC_009614.1 Bacteroides vulgatus 1754976 1755668 NC_009614.1 Bacteroides vulgatus 229513 228737 NZ_AAVM02000003.1 Bacteroides caccae 185072 186076 NZ_AAVN02000002.1 Collinsella aerofaciens 330089 328836 NZ_AAYG02000009.1 Ruminococcus gnavus 76928 78010 NZ_AAYG02000020.1 Ruminococcus gnavus 155246 154575 NZ_ABJL02000006.1 Bacteroides intestinalis 172076 171060 NZ_ABJL02000006.1 Bacteroides intestinalis 163000 161969 NZ_ABJL02000007.1 Bacteroides intestinalis 472617 473339 NZ_ABJL02000007.1 Bacteroides intestinalis 480076 480798 NZ_ABJL02000008.1 Bacteroides intestinalis 2829172 2828048 NZ_ABJL02000008.1 Bacteroides intestinalis 1177965 1176991 NZ_ABJL02000008.1 Bacteroides intestinalis 1188047 1187424 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 967512 968423 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 822055 822963 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 746022 745300 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 196151 195027 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 349394 350368 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 448433 449446 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 339279 339935 NZ_ATFI01000010.1 Bacteroides cellulosilyticus 52643 53737 NZ_ATFI01000013.1 Bacteroides cellulosilyticus 164808 163792 NZ_ATFI01000013.1 Bacteroides cellulosilyticus 152238 151207 NZ_ATFI01000018.1 Bacteroides cellulosilyticus 141668 142606 NZ_ATFI01000018.1 Bacteroides cellulosilyticus 132297 133130 NZ_CVOY01000002.1 Bacteroides thetaiotaomicron 3895 4776 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 31282 32286 NZ_CVOY01000033.1 Bacteroides thetaiotaomicron 54890 55870 NZ_CVOY01000047.1 Bacteroides thetaiotaomicron 51696 52331 NZ_CVOY01000055.1 Bacteroides thetaiotaomicron 60965 59871 NZ_DS264461.1 Parabacteroides merdae 153316 152396 NZ_DS264554.1 Bacteroides ovatus 520925 520290 NZ_DS264582.1 Bacteroides ovatus 485007 483871 NZ_DS264584.1 Bacteroides ovatus 299154 300158 NZ_DS264584.1 Bacteroides ovatus 459996 461081 NZ_DS264584.1 Bacteroides ovatus 422114 422995 NZ_DS480676.1 Clostridium bolteae 33135 34307 NZ_DS480689.1 Clostridium bolteae 189055 188054 NZ_DS480702.1 Clostridium bolteae 114722 114084 NZ_DS499669.1 Bacteroides stercoris 54603 53575 NZ_DS499669.1 Bacteroides stercoris 41098 40067 NZ_DS499676.1 Bacteroides stercoris 563727 562723 NZ_DS995509.1 Bacteroides eggerthii 324943 326016 NZ_DS995509.1 Bacteroides eggerthii 32959 31790 NZ_DS995531.1 Bacteroides dorei 131233 132258 NZ_DS995534.1 Bacteroides dorei 665227 665934 NZ_DS995536.1 Bacteroides dorei 158689 159771 NZ_DS995536.1 Bacteroides dorei 286827 285820 NZ_DS995537.1 Bacteroides dorei 839046 840131 NZ_DS996445.1 Parabacteroides johnsonii 309779 310801 NZ_DS996453.1 Parabacteroides johnsonii 946 44 NZ_DS996453.1 Parabacteroides johnsonii 541071 541673 NZ_DS996921.1 Bacteroides pectinophilus 1792409 1793536 NZ_DS996921.1 Bacteroides pectinophilus 1408311 1409351 NZ_EQ973488.1 Bacteroides cellulosilyticus 305101 305769 NZ_EQ973488.1 Bacteroides cellulosilyticus 318355 318765 NZ_EQ973489.1 Bacteroides cellulosilyticus 401883 400945 NZ_EQ973489.1 Bacteroides cellulosilyticus 411254 410421 NZ_EQ973490.1 Bacteroides cellulosilyticus 49277 48261 NZ_EQ973490.1 Bacteroides cellulosilyticus 1172225 1173136 NZ_EQ973490.1 Bacteroides cellulosilyticus 36535 35504 NZ_EQ973490.1 Bacteroides cellulosilyticus 840046 839324 NZ_EQ973491.1 Bacteroides cellulosilyticus 390345 391469 NZ_EQ973495.1 Bacteroides cellulosilyticus 334170 333598 NZ_EQ973495.1 Bacteroides cellulosilyticus 227993 226980 NZ_EQ973495.1 Bacteroides cellulosilyticus 344769 344113 NZ_GG657591.1 Clostridium asparagiforme 931520 932323 NZ_GG657591.1 Clostridium asparagiforme 935934 936779 NZ_GG657595.1 Clostridium asparagiforme 537115 538233 NZ_GG667607.1 Hungatella hathewayi 113320 112511 NZ_GG667617.1 Hungatella hathewayi 14231 14869 NZ_GG667628.1 Hungatella hathewayi 38593 38027 NZ_GG688320.1 Bacteroides finegoldii 267192 266188 NZ_GG688320.1 Bacteroides finegoldii 173035 171950 NZ_GG688323.1 Bacteroides finegoldii 83014 84108 NZ_GG692716.1 Roseburia intestinalis 72286 72888 NZ_GG692716.1 Roseburia intestinalis 71753 72295 NZ_GG703852.1 Prevotella copri 90990 89896 NZ_GG704863.1 Enterobacter cancerogenus 1562280 1561468 NZ_JH724294.1 Bacteroides xylanisolvens 1862842 1861706 NZ_JH724294.1 Bacteroides xylanisolvens 388065 389069 NZ_JH724295.1 Bacteroides xylanisolvens 302144 301509 NZ_JH724295.1 Bacteroides xylanisolvens 278743 278141 NZ_PUEL01000004.1 Ruminococcus gnavus 2996334 2997416 NZ_PUEL01000004.1 Ruminococcus gnavus 1640981 1640310 NZ_PUEM01000006.1 Clostridium bolteae 1701794 1700622 NZ_PUEM01000006.1 Clostridium bolteae 3657608 3658609 NZ_PUEM01000006.1 Clostridium bolteae 4021074 4021712 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3061847 3062941 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 897383 898387 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 1024402 1025283 NZ_PUEP01000005.1 Bacteroides ovatus 1564102 1565238 NZ_PUEP01000005.1 Bacteroides ovatus 3146595 3145591 NZ_PUEP01000005.1 Bacteroides ovatus 2985753 2984668 NZ_PUEP01000005.1 Bacteroides ovatus 5075403 5076038 NZ_PUEP01000005.1 Bacteroides ovatus 3023635 3022754 NZ_PUEP01000005.1 Bacteroides ovatus 5098803 5099405 NZ_PUEQ01000003.1 Bacteroides caccae 2519904 2518900 BACDOR_03379 104 279 BACDOR_03642 343 492 BT_0445 202 292 BT_2961 108 281 CVOZ01000011.1 Bacteroides thetaiotaomicron 76510 77013 NC_012781.1 Eubacterium rectale 1183363 1183959 NZ_AAVN02000002.1 Collinsella aerofaciens 330907 330182 NZ_DS996456.1 Parabacteroides johnsonii 448969 448454 NZ_DS996921.1 Bacteroides pectinophilus 215363 215845 NZ_JH724300.1 Bacteroides xylanisolvens 14445 13921 NZ_AAVN02000002.1 Collinsella aerofaciens 331231 331860 NZ_DS996921.1 Bacteroides pectinophilus 2180486 2181052 CVOZ01000033.1 Bacteroides thetaiotaomicron 39992 39123 CVOZ01000033.1 Bacteroides thetaiotaomicron 38164 37274 JGCP01001040.1 Bacteroides fragilis 1038 415 JGCP01001049.1 Bacteroides fragilis 113 619 JGCP01001118.1 Bacteroides fragilis 510 25 NC_000913.3 Escherichia coli 806660 806118 NC_009614.1 Bacteroides vulgatus 2317377 2318246 NC_009614.1 Bacteroides vulgatus 2352958 2353836 NZ_AAVM02000003.1 Bacteroides caccae 186200 186913 NZ_AAVM02000003.1 Bacteroides caccae 188146 189024 NZ_AAVN02000002.1 Collinsella aerofaciens 333085 331844 NZ_ABJL02000008.1 Bacteroides intestinalis 2827911 2827084 NZ_ABJL02000008.1 Bacteroides intestinalis 2825593 2824715 NZ_ABJL02000008.1 Bacteroides intestinalis 2763149 2762139 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 194890 194012 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 192550 191672 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 116394 115324 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 32407 33276 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 34236 35126 NZ_DS264581.1 Bacteroides ovatus 361113 361889 NZ_DS264581.1 Bacteroides ovatus 372065 372856 NZ_DS264584.1 Bacteroides ovatus 300282 301151 NZ_DS264584.1 Bacteroides ovatus 302363 303262 NZ_DS264584.1 Bacteroides ovatus 314236 313235 NZ_DS480674.1 Clostridium bolteae 63437 62442 NZ_DS499676.1 Bacteroides stercoris 560446 559568 NZ_DS499676.1 Bacteroides stercoris 562585 561713 NZ_DS499676.1 Bacteroides stercoris 526258 525236 NZ_DS990238.1 Bifidobacterium longum 757614 756904 NZ_DS995509.1 Bacteroides eggerthii 326173 327018 NZ_DS995509.1 Bacteroides eggerthii 328317 329195 NZ_DS995536.1 Bacteroides dorei 285685 284816 NZ_DS995536.1 Bacteroides dorei 241608 240730 NZ_DS996923.1 Bacteroides pectinophilus 73704 72955 NZ_EQ973491.1 Bacteroides cellulosilyticus 391606 392484 NZ_EQ973491.1 Bacteroides cellulosilyticus 393946 394824 NZ_EQ973491.1 Bacteroides cellulosilyticus 464286 465356 NZ_GG688320.1 Bacteroides finegoldii 266145 265276 NZ_GG688320.1 Bacteroides finegoldii 264126 263248 NZ_GG688320.1 Bacteroides finegoldii 254019 255143 NZ_GG688326.1 Bacteroides finegoldii 33875 33099 NZ_GG688326.1 Bacteroides finegoldii 22923 22132 NZ_GG692728.1 Roseburia intestinalis 82828 83886 NZ_GG703853.1 Prevotella copri 101373 100462 NZ_GG704864.1 Enterobacter cancerogenus 507462 506914 NZ_JH724294.1 Bacteroides xylanisolvens 389193 390062 NZ_JH724294.1 Bacteroides xylanisolvens 391274 392140 NZ_JH724295.1 Bacteroides xylanisolvens 1554618 1555394 NZ_JH724295.1 Bacteroides xylanisolvens 1565570 1566361 NZ_PUEM01000006.1 Clostridium bolteae 5178002 5177007 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 898508 899377 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 900337 901227 NZ_PUEP01000005.1 Bacteroides ovatus 3145467 3144598 NZ_PUEP01000005.1 Bacteroides ovatus 3143386 3142487 NZ_PUEP01000005.1 Bacteroides ovatus 3789254 3788478 NZ_PUEP01000005.1 Bacteroides ovatus 3778302 3777511 NZ_PUEP01000005.1 Bacteroides ovatus 3131513 3132514 NZ_PUEQ01000003.1 Bacteroides caccae 2518776 2517907 NZ_PUEQ01000003.1 Bacteroides caccae 2516829 2515951 BACDOR_00571 1 57 BACDOR_03988 41 155 BT_1006 1 62 BT_1148 5 170 CVOZ01000044.1 Bacteroides thetaiotaomicron 270178 270675 CVOZ01000063.1 Bacteroides thetaiotaomicron 213252 213776 JGCP01002451.1 Bacteroides fragilis 27278 27826 JGCP01002532.1 Bacteroides fragilis 1990 1631 NC_009614.1 Bacteroides vulgatus 2553345 2553821 NC_009614.1 Bacteroides vulgatus 1289396 1288902 NC_009614.1 Bacteroides vulgatus 3238578 3238234 NC_009615.1 Parabacteroides distasonis 2044483 2044857 NC_012781.1 Eubacterium rectale 1600354 1600857 NZ_AAVM02000001.1 Bacteroides caccae 1119727 1119179 NZ_AAVN02000007.1 Collinsella aerofaciens 43328 42810 NZ_AAXA02000015.1 Dorea formicigenerans 428152 428658 NZ_AAXA02000015.1 Dorea formicigenerans 812485 812937 NZ_AAYG02000005.1 Ruminococcus gnavus 169559 170014 NZ_ABJL02000007.1 Bacteroides intestinalis 959642 959145 NZ_ABJL02000008.1 Bacteroides intestinalis 574710 574237 NZ_ABXA01000037.1 Anaerococcus hydrogenalis 15300 14881 NZ_ACCL02000007.1 Marvinbryantia formatexigens 30299 30799 NZ_ACEP01000002.1 Eubacterium hallii 34255 34773 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 1579899 1579402 NZ_ATFI01000012.1 Bacteroides cellulosilyticus 48936 48463 NZ_CVOY01000042.1 Bacteroides thetaiotaomicron 62958 62434 NZ_CVOY01000048.1 Bacteroides thetaiotaomicron 31368 31865 NZ_DS264270.1 Eubacterium ventriosum 212238 212747 NZ_DS264542.1 Parabacteroides merdae 249192 248833 NZ_DS264582.1 Bacteroides ovatus 368681 369235 NZ_DS362244.1 Bacteroides uniformis 170469 171023 NZ_DS362248.1 Bacteroides uniformis 308163 308660 NZ_DS480690.1 Clostridium bolteae 244844 244341 NZ_DS480692.1 Clostridium bolteae 142185 141841 NZ_DS499659.1 Erysipelatoclostridium ramosum 548774 548271 NZ_DS499672.1 Bacteroides stercoris 113154 113663 NZ_DS499674.1 Bacteroides stercoris 145536 146033 NZ_DS499701.1 Clostridium scindens 43478 43023 NZ_DS544193.1 Anaerotruncus colihominis 200258 200770 NZ_DS562846.1 Clostridium spiroforme 146418 145852 NZ_DS981517.1 Clostridium sporogenes 2367346 2367882 NZ_DS981518.1 Clostridium sporogenes 524044 524544 NZ_DS990201.1 Ruminococcus lactaris 50105 50611 NZ_DS995510.1 Bacteroides eggerthii 730877 731395 NZ_DS995511.1 Bacteroides eggerthii 244997 245494 NZ_DS995534.1 Bacteroides dorei 71640 71146 NZ_DS995536.1 Bacteroides dorei 38622 38146 NZ_DS995537.1 Bacteroides dorei 674814 674470 NZ_DS996446.1 Parabacteroides johnsonii 59119 59580 NZ_DS996841.1 Holdemanella biformis 240823 240320 NZ_DS996844.1 Holdemanella biformis 9201 9716 NZ_DS996847.1 Holdemanella biformis 35952 36299 NZ_DS996921.1 Bacteroides pectinophilus 1377570 1378040 NZ_EQ973490.1 Bacteroides cellulosilyticus 1771262 1770765 NZ_EQ973492.1 Bacteroides cellulosilyticus 269763 270236 NZ_EQ973631.1 Bacteroides coprophilus 166069 166566 NZ_EQ973635.1 Bacteroides coprophilus 157971 157465 NZ_EQ973650.1 Bacteroides coprophilus 309678 310139 NZ_EQ973651.1 Bacteroides coprophilus 186918 186481 NZ_GG657587.1 Clostridium asparagiforme 626172 625822 NZ_GG657592.1 Clostridium asparagiforme 256639 256139 NZ_GG657592.1 Clostridium asparagiforme 2004022 2003468 NZ_GG662014.1 Coprococcus comes 263241 263747 NZ_GG662014.1 Coprococcus comes 272780 273106 NZ_GG688323.1 Bacteroides finegoldii 185574 185020 NZ_GG688343.1 Bacteroides finegoldii 10025 9510 NZ_GG692710.1 Collinsella intestinalis 212696 213166 NZ_GG692721.1 Roseburia intestinalis 15573 16079 NZ_GG698591.1 Blautia hansenii 291863 291519 NZ_GG703859.1 Prevotella copri 138307 138801 NZ_GG704769.1 Subdoligranulum variabile 1245783 1245277 NZ_GG704774.1 Subdoligranulum variabile 1821 2216 NZ_JGDE01000083.1 Bacteroides fragilis 52785 53333 NZ_JGDE01000126.1 Bacteroides fragilis 19699 19340 NZ_JH370371.1 Alistipes indistinctus 1289779 1289264 NZ_JH724294.1 Bacteroides xylanisolvens 1743283 1743837 NZ_KE993038.1 Clostridium symbiosum 28571 29017 NZ_MTWC01000003.1 Clostridioides difficile 851741 852091 NZ_MTWC01000003.1 Clostridioides difficile 764221 764625 NZ_MTWC01000003.1 Clostridioides difficile 3694907 3694437 NZ_MTWD01000001.1 Clostridioides difficile 951757 952107 NZ_MTWD01000001.1 Clostridioides difficile 864279 864683 NZ_MTWD01000001.1 Clostridioides difficile 3699874 3699404 NZ_MTWE01000004.1 Clostridioides difficile 3086150 3086656 NZ_MTWE01000004.1 Clostridioides difficile 644554 644913 NZ_MTWE01000004.1 Clostridioides difficile 562111 562515 NZ_MTWE01000004.1 Clostridioides difficile 3362803 3362396 NZ_MTWF01000010.1 Clostridioides difficile 538758 539108 NZ_MTWF01000010.1 Clostridioides difficile 451169 451573 NZ_MTWF01000021.1 Clostridioides difficile 734579 734109 NZ_PPUH01000002.1 Eggerthella lenta 235541 236044 NZ_PUEL01000004.1 Ruminococcus gnavus 215261 214806 NZ_PUEM01000006.1 Clostridium bolteae 4914472 4913969 NZ_PUEM01000006.1 Clostridium bolteae 4326890 4327234 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 3235791 3235294 NZ_PUEP01000005.1 Bacteroides ovatus 1680428 1679874 NZ_PUEQ01000003.1 Bacteroides caccae 1408538 1407990 NZ_UFTH01000001.1 Bacteroides fragilis 4377477 4378025 NZ_UFTH01000001.1 Bacteroides fragilis 627443 627084 NZ_UFTH01000002.1 Bacteroides fragilis 31675 32046 JGCP01000859.1 Bacteroides fragilis 247 660 JGCP01002352.1 Bacteroides fragilis 14649 15062 NC_000913.3 Escherichia coli 3231665 3233218 NC_008618.1 Bifidobacterium adolescentis 1689422 1688412 NC_009614.1 Bacteroides vulgatus 1477586 1477173 NC_012781.1 Eubacterium rectale 2728515 2729615 NZ_AAVM02000002.1 Bacteroides caccae 251699 252112 NZ_AAVN02000002.1 Collinsella aerofaciens 326185 324458 NZ_AAVN02000008.1 Collinsella aerofaciens 49145 47112 NZ_AAYG02000005.1 Ruminococcus gnavus 53408 52044 NZ_AAYG02000005.1 Ruminococcus gnavus 53906 53610 NZ_AAYG02000018.1 Ruminococcus gnavus 115281 114544 NZ_AAYG02000018.1 Ruminococcus gnavus 114545 113859 NZ_AAYG02000020.1 Ruminococcus gnavus 33742 31967 NZ_ABXW01000007.1 Providencia alcalifaciens 83384 82374 NZ_ABXW01000014.1 Providencia alcalifaciens 201354 200305 NZ_ABXW01000019.1 Providencia alcalifaciens 39201 39665 NZ_ABXW01000047.1 Providencia alcalifaciens 151003 149450 NZ_ACCL02000002.1 Marvinbryantia formatexigens 238233 239315 NZ_ACEP01000036.1 Eubacterium hallii 20427 18634 NZ_ACEP01000036.1 Eubacterium hallii 6263 6859 NZ_ACEP01000054.1 Eubacterium hallii 38370 37309 NZ_AHVA01000007.1 Salmonella enterica 585091 586644 NZ_DS264365.1 Ruminococcus torques 38444 36861 NZ_DS264366.1 Ruminococcus torques 14189 12285 NZ_DS264366.1 Ruminococcus torques 12251 10338 NZ_DS264374.1 Ruminococcus torques 22043 20577 NZ_DS264376.1 Ruminococcus torques 81045 82469 NZ_DS264579.1 Bacteroides ovatus 391612 392025 NZ_DS480725.1 Clostridium bolteae 73291 75168 NZ_DS499653.1 Erysipelatoclostridium ramosum 163876 161984 NZ_DS499655.1 Erysipelatoclostridium ramosum 92494 94494 NZ_DS499659.1 Erysipelatoclostridium ramosum 820298 822214 NZ_DS499659.1 Erysipelatoclostridium ramosum 187711 189624 NZ_DS499659.1 Erysipelatoclostridium ramosum 830720 828918 NZ_DS499659.1 Erysipelatoclostridium ramosum 818839 819687 NZ_DS499659.1 Erysipelatoclostridium ramosum 811198 809723 NZ_DS499659.1 Erysipelatoclostridium ramosum 818320 818655 NZ_DS499674.1 Bacteroides stercoris 281199 280756 NZ_DS499678.1 Clostridium scindens 34299 33472 NZ_DS499684.1 Clostridium scindens 29932 31860 NZ_DS499697.1 Clostridium scindens 295175 293268 NZ_DS499710.1 Clostridium scindens 88907 87510 NZ_DS499710.1 Clostridium scindens 82861 81515 NZ_DS499710.1 Clostridium scindens 83371 83048 NZ_DS499710.1 Clostridium scindens 89399 89103 NZ_DS607663.1 Providencia stuartii 624169 623150 NZ_DS607678.1 Providencia stuartii 131768 133240 NZ_DS981517.1 Clostridium sporogenes 1504597 1506570 NZ_DS990176.1 Ruminococcus lactaris 30347 30943 NZ_DS990176.1 Ruminococcus lactaris 29846 30169 NZ_DS990190.1 Ruminococcus lactaris 3899 2472 NZ_DS990238.1 Bifidobacterium longum 255030 254731 NZ_DS990238.1 Bifidobacterium longum 255196 255005 NZ_DS995534.1 Bacteroides dorei 335106 334693 NZ_DS996444.1 Parabacteroides johnsonii 867248 867835 NZ_DS996841.1 Holdemanella biformis 213342 211348 NZ_DS996841.1 Holdemanella biformis 215261 213360 NZ_DS996841.1 Holdemanella biformis 167745 166951 NZ_DS996841.1 Holdemanella biformis 168255 167947 NZ_DS996842.1 Holdemanella biformis 294507 293134 NZ_DS996844.1 Holdemanella biformis 11340 9940 NZ_GG657591.1 Clostridium asparagiforme 187173 186097 NZ_GG657592.1 Clostridium asparagiforme 3032918 3034684 NZ_GG657592.1 Clostridium asparagiforme 1876564 1874570 NZ_GG657592.1 Clostridium asparagiforme 3069663 3067939 NZ_GG657592.1 Clostridium asparagiforme 2542323 2540860 NZ_GG661994.1 Proteus penneri 222623 221616 NZ_GG661996.1 Proteus penneri 924601 925488 NZ_GG661996.1 Proteus penneri 924431 924589 NZ_GG661996.1 Proteus penneri 923938 924240 NZ_GG662014.1 Coprococcus comes 645523 644906 NZ_GG662014.1 Coprococcus comes 646024 645701 NZ_GG667620.1 Hungatella hathewayi 7252 6188 NZ_GG667622.1 Hungatella hathewayi 37613 39523 NZ_GG667690.1 Hungatella hathewayi 16181 14763 NZ_GG667690.1 Hungatella hathewayi 14690 13062 NZ_GG667690.1 Hungatella hathewayi 16682 16383 NZ_GG688332.1 Bacteroides finegoldii 98265 98678 NZ_GG692710.1 Collinsella intestinalis 1185313 1183391 NZ_GG692717.1 Roseburia intestinalis 224174 223578 NZ_GG692717.1 Roseburia intestinalis 224675 224352 NZ_GG692736.1 Roseburia intestinalis 17269 15341 NZ_GG704769.1 Subdoligranulum variabile 78938 80308 NZ_GG704769.1 Subdoligranulum variabile 2209221 2208253 NZ_GG704771.1 Subdoligranulum variabile 256941 258851 NZ_GG704865.1 Enterobacter cancerogenus 770824 771876 NZ_GG704865.1 Enterobacter cancerogenus 770338 770634 NZ_GG705262.1 Providencia rettgeri 1574659 1576197 NZ_GG705262.1 Providencia rettgeri 701537 702553 NZ_GG705263.1 Providencia rettgeri 326238 325780 NZ_GG729830.1 Bifidobacterium breve 608625 609662 NZ_GG739633.1 Edwardsiella tarda 1475528 1475019 NZ_JGDE01000165.1 Bacteroides fragilis 75469 75882 NZ_JH724295.1 Bacteroides xylanisolvens 710795 711208 NZ_KE992800.1 Clostridium symbiosum 26653 24728 NZ_KE992800.1 Clostridium symbiosum 28977 30416 NZ_MTWC01000003.1 Clostridioides difficile 3079200 3078121 NZ_MTWC01000003.1 Clostridioides difficile 2889511 2888225 NZ_MTWC01000003.1 Clostridioides difficile 2890009 2889704 NZ_MTWD01000001.1 Clostridioides difficile 3091419 3090340 NZ_MTWD01000001.1 Clostridioides difficile 2930504 2929218 NZ_MTWD01000001.1 Clostridioides difficile 2931002 2930697 NZ_MTWE01000004.1 Clostridioides difficile 3102040 3100103 NZ_MTWE01000004.1 Clostridioides difficile 2802748 2801669 NZ_MTWE01000004.1 Clostridioides difficile 2648868 2647582 NZ_MTWE01000004.1 Clostridioides difficile 2649366 2649061 NZ_MTWF01000021.1 Clostridioides difficile 150497 149418 NZ_PPUH01000004.1 Eggerthella lenta 75047 76951 NZ_PPUH01000004.1 Eggerthella lenta 77693 78493 NZ_PPUH01000004.1 Eggerthella lenta 174728 175240 NZ_PUEL01000004.1 Ruminococcus gnavus 2242708 2240789 NZ_PUEL01000004.1 Ruminococcus gnavus 820113 822041 NZ_PUEL01000004.1 Ruminococcus gnavus 1519478 1517703 NZ_PUEL01000004.1 Ruminococcus gnavus 331413 332777 NZ_PUEL01000004.1 Ruminococcus gnavus 657923 656505 NZ_PUEL01000004.1 Ruminococcus gnavus 2201457 2200561 NZ_PUEL01000004.1 Ruminococcus gnavus 330915 331211 NZ_PUEM01000006.1 Clostridium bolteae 2793257 2795134 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 1043585 1044007 NZ_PUEP01000005.1 Bacteroides ovatus 4630286 4629873 NZ_PUEQ01000003.1 Bacteroides caccae 3370211 3369798 NZ_UFTH01000001.1 Bacteroides fragilis 1975000 1975413 QEKH01000021.1 Victivallis vadensis 49835 50419 BACDOR_03937 52 92 BT_1192 37 160 CVOZ01000002.1 Bacteroides thetaiotaomicron 27472 28101 CVOZ01000011.1 Bacteroides thetaiotaomicron 27140 27421 NC_000913.3 Escherichia coli 499727 499083 NC_012781.1 Eubacterium rectale 2291176 2290535 NZ_AAVN02000008.1 Collinsella aerofaciens 95394 94330 NZ_AAXA02000008.1 Dorea formicigenerans 69701 70546 NZ_AAXA02000008.1 Dorea formicigenerans 71748 72386 NZ_AAXA02000009.1 Dorea formicigenerans 62902 62264 NZ_AAYG02000031.1 Ruminococcus gnavus 40641 39991 NZ_ABXWO1000046.1 Providencia alcalifaciens 144717 144040 NZ_ACCL02000001.1 Marvinbryantia formatexigens 132276 132626 NZ_ATFI01000001.1 Bacteroides cellulosilyticus 965679 965404 NZ_DS264269.1 Eubacterium ventriosum 21943 23007 NZ_DS264517.1 Parabacteroides merdae 22275 22898 NZ_DS480686.1 Clostridium bolteae 99911 99264 NZ_DS499709.1 Clostridium scindens 27922 27179 NZ_DS544180.1 Anaerotruncus colihominis 47523 48269 NZ_DS981517.1 Clostridium sporogenes 1498487 1499116 NZ_DS990176.1 Ruminococcus lactaris 24402 24085 NZ_DS996453.1 Parabacteroides johnsonii 2536 1919 NZ_DS996921.1 Bacteroides pectinophilus 1518411 1519052 NZ_EQ973490.1 Bacteroides cellulosilyticus 1170390 1170115 NZ_GG657590.1 Clostridium asparagiforme 216404 215709 NZ_GG657591.1 Clostridium asparagiforme 525486 524806 NZ_GG657592.1 Clostridium asparagiforme 1824491 1824808 NZ_GG657592.1 Clostridium asparagiforme 958061 957219 NZ_GG657592.1 Clostridium asparagiforme 1368813 1368559 NZ_GG657595.1 Clostridium asparagiforme 413311 412655 NZ_GG661997.1 Proteus penneri 158305 158997 NZ_GG662010.1 Coprococcus comes 133481 132858 NZ_GG667612.1 Hungatella hathewayi 83476 84156 NZ_GG667653.1 Hungatella hathewayi 9768 10541 NZ_GG667663.1 Hungatella hathewayi 28932 29255 NZ_GG688324.1 Bacteroides finegoldii 191844 191179 NZ_GG692718.1 Roseburia intestinalis 13388 12747 NZ_GG692729.1 Roseburia intestinalis 23802 23545 NZ_GG703854.1 Prevotella copri 344197 344454 NZ_GG703864.1 Prevotella copri 76937 77305 NZ_GG704769.1 Subdoligranulum variabile 569661 570269 NZ_GG704770.1 Subdoligranulum variabile 279973 280239 NZ_GG704867.1 Enterobacter cancerogenus 32796 32065 NZ_GG705262.1 Providencia rettgeri 737987 738844 NZ_GG739633.1 Edwardsiella tarda 2215417 2214740 NZ_KE992946.1 Clostridium symbiosum 16142 16942 NZ_PUEL01000004.1 Ruminococcus gnavus 1068338 1067598 NZ_PUEM01000006.1 Clostridium bolteae 3409802 3410449 NZ_PUEO01000004.1 Bacteroides thetaiotaomicron 909868 909239 QEKH01000003.1 Victivallis vadensis 74432 75064 QEKH01000014.1 Victivallis vadensis 38351 38740 QEKH01000019.1 Victivallis vadensis 58559 57939 NC_012781.1 Eubacterium rectale 3213966 3213511 NC_012781.1 Eubacterium rectale 3389503 3389354 NZ_AAVN02000015.1 Collinsella aerofaciens 28383 27748 NZ_DS996455.1 Parabacteroides johnsonii 38505 38065 NZ_DS996923.1 Bacteroides pectinophilus 151384 150950 NZ_GG662014.1 Coprococcus comes 572680 573108 NZ_GG692710.1 Collinsella intestinalis 1019998 1020606 NZ_GG704769.1 Subdoligranulum variabile 1665742 1666170 NZ_MTWE01000004.1 Clostridioides difficile 130482 130892 NZ_DS499679.1 Clostridium scindens 6626 6823 NZ_DS499680.1 Clostridium scindens 39909 40277 NZ_DS499698.1 Clostridium scindens 86368 86784 NZ_GG692724.1 Roseburia intestinalis 114328 114747 NZ_GG692735.1 Roseburia intestinalis 3089 3505 NZ_GG692775.1 Roseburia intestinalis 9058 9255 NZ_GG692775.1 Roseburia intestinalis 9246 9338 NZ_GG692783.1 Roseburia intestinalis 258 347 NZ_DS264270.1 Eubacterium ventriosum 117297 117686 NZ_DS264270.1 Eubacterium ventriosum 117008 117298 NZ_DS499698.1 Clostridium scindens 87519 86782 NZ_DS499700.1 Clostridium scindens 21096 20401 NZ_GG662007.1 Coprococcus comes 543307 543696 NZ_GG662007.1 Coprococcus comes 543102 543311 NZ_GG703852.1 Prevotella copri 145367 145672 NZ_GG703860.1 Prevotella copri 53657 53133 NZ_GG703860.1 Prevotella copri 54778 54395 NC_008618.1 Bifidobacterium adolescentis 964374 964060 NC_012781.1 Eubacterium rectale 992985 993416 NC_012781.1 Eubacterium rectale 1393674 1394102 NZ_AAVN02000001.1 Collinsella aerofaciens 457597 458028 NZ_AAVN02000002.1 Collinsella aerofaciens 91743 90853 NZ_AAXA02000006.1 Dorea formicigenerans 4930 4118 NZ_AAXA02000007.1 Dorea formicigenerans 75838 76302 NZ_AAXA02000012.1 Dorea formicigenerans 143739 143305 NZ_AAXA02000014.1 Dorea formicigenerans 8125 8556 NZ_AAXA02000014.1 Dorea formicigenerans 9822 10076 NZ_AAXA02000015.1 Dorea formicigenerans 114251 113727 NZ_AAXA02000016.1 Dorea formicigenerans 118699 118268 NZ_ABXA01000032.1 Anaerococcus hydrogenalis 34181 34612 NZ_ABXA01000043.1 Anaerococcus hydrogenalis 135344 135775 NZ_ABXW01000049.1 Providencia alcalifaciens 145285 145707 NZ_ACCL02000001.1 Marvinbryantia formatexigens 57072 56389 NZ_ACCL02000014.1 Marvinbryantia formatexigens 117997 118428 NZ_ACCL02000014.1 Marvinbryantia formatexigens 75359 75772 NZ_ACCL02000033.1 Marvinbryantia formatexigens 13896 13381 NZ_ACEP01000042.1 Eubacterium hallii 5704 5186 NZ_ACEP01000171.1 Eubacterium hallii 13836 13606 NZ_AHVA01000007.1 Salmonella enterica 612224 611889 NZ_AHVA01000007.1 Salmonella enterica 380642 380214 NZ_DS264265.1 Eubacterium ventriosum 210966 210535 NZ_DS264270.1 Eubacterium ventriosum 218825 219256 NZ_DS264344.1 Ruminococcus torques 61376 60936 NZ_DS480671.1 Clostridium bolteae 257033 256143 NZ_DS480671.1 Clostridium bolteae 83250 82915 NZ_DS480680.1 Clostridium bolteae 299464 299204 NZ_DS480690.1 Clostridium bolteae 111366 111980 NZ_DS480694.1 Clostridium bolteae 234643 233795 NZ_DS480694.1 Clostridium bolteae 405777 405625 NZ_DS480694.1 Clostridium bolteae 311382 311744 NZ_DS480694.1 Clostridium bolteae 371292 371077 NZ_DS480723.1 Clostridium bolteae 101986 101747 NZ_DS499654.1 Erysipelatoclostridium ramosum 170533 170264 NZ_DS499654.1 Erysipelatoclostridium ramosum 200127 200339 NZ_DS499655.1 Erysipelatoclostridium ramosum 450584 451015 NZ_DS499655.1 Erysipelatoclostridium ramosum 542015 542440 NZ_DS499656.1 Erysipelatoclostridium ramosum 185343 185780 NZ_DS499660.1 Erysipelatoclostridium ramosum 11106 11321 NZ_DS499680.1 Clostridium scindens 6317 6895 NZ_DS499691.1 Clostridium scindens 857 36 NZ_DS499694.1 Clostridium scindens 1192 683 NZ_DS499698.1 Clostridium scindens 88546 87611 NZ_DS499705.1 Clostridium scindens 87758 87324 NZ_DS499710.1 Clostridium scindens 106171 105356 NZ_DS499714.1 Clostridium scindens 7330 7908 NZ_DS499718.1 Clostridium scindens 379001 378474 NZ_DS544185.1 Anaerotruncus colihominis 244252 243629 NZ_DS544185.1 Anaerotruncus colihominis 232765 232478 NZ_DS544188.1 Anaerotruncus colihominis 264851 264282 NZ_DS544193.1 Anaerotruncus colihominis 198228 198013 NZ_DS562853.1 Clostridium spiroforme 198492 198923 NZ_DS562853.1 Clostridium spiroforme 337920 338357 NZ_DS607663.1 Providencia stuartii 885247 885516 NZ_DS607670.1 Providencia stuartii 93145 93360 NZ_DS981517.1 Clostridium sporogenes 2147870 2148421 NZ_DS981518.1 Clostridium sporogenes 505394 504957 NZ_DS981518.1 Clostridium sporogenes 896212 896361 NZ_DS990163.1 Ruminococcus lactaris 69898 69683 NZ_DS990202.1 Ruminococcus lactaris 150898 151329 NZ_DS990239.1 Bifidobacterium longum 417566 416994 NZ_DS996841.1 Holdemanella biformis 302699 303286 NZ_DS996843.1 Holdemanella biformis 156961 157398 NZ_DS996846.1 Holdemanella biformis 91009 90554 NZ_DS996921.1 Bacteroides pectinophilus 1770364 1769933 NZ_GG657587.1 Clostridium asparagiforme 197966 198217 NZ_GG657587.1 Clostridium asparagiforme 484513 484328 NZ_GG657587.1 Clostridium asparagiforme 462837 462550 NZ_GG657587.1 Clostridium asparagiforme 568461 568700 NZ_GG657589.1 Clostridium asparagiforme 86677 87105 NZ_GG657590.1 Clostridium asparagiforme 174026 174313 NZ_GG657590.1 Clostridium asparagiforme 132367 131576 NZ_GG657591.1 Clostridium asparagiforme 926075 926557 NZ_GG657592.1 Clostridium asparagiforme 2125178 2125744 NZ_GG657592.1 Clostridium asparagiforme 2150188 2149304 NZ_GG657592.1 Clostridium asparagiforme 35707 35865 NZ_GG657592.1 Clostridium asparagiforme 54324 54085 NZ_GG657592.1 Clostridium asparagiforme 2149209 2148745 NZ_GG657592.1 Clostridium asparagiforme 1241014 1241166 NZ_GG657592.1 Clostridium asparagiforme 53378 53037 NZ_GG657592.1 Clostridium asparagiforme 2939085 2939318 NZ_GG657592.1 Clostridium asparagiforme 253538 253311 NZ_GG657592.1 Clostridium asparagiforme 1931348 1931782 NZ_GG657592.1 Clostridium asparagiforme 1199059 1198841 NZ_GG657592.1 Clostridium asparagiforme 1304859 1305089 NZ_GG657592.1 Clostridium asparagiforme 2964883 2964650 NZ_GG657592.1 Clostridium asparagiforme 1583120 1583629 NZ_GG657676.1 Clostridium asparagiforme 122 361 NZ_GG662007.1 Coprococcus comes 232709 232482 NZ_GG662010.1 Coprococcus comes 47027 46236 NZ_GG662010.1 Coprococcus comes 147979 147725 NZ_GG662012.1 Coprococcus comes 9623 10057 NZ_GG662014.1 Coprococcus comes 261751 261320 NZ_GG667610.1 Hungatella hathewayi 84423 83608 NZ_GG667612.1 Hungatella hathewayi 35585 35040 NZ_GG667612.1 Hungatella hathewayi 51608 51405 NZ_GG667615.1 Hungatella hathewayi 61630 62061 NZ_GG667627.1 Hungatella hathewayi 29759 30193 NZ_GG667675.1 Hungatella hathewayi 6837 6418 NZ_GG692710.1 Collinsella intestinalis 133099 132209 NZ_GG692719.1 Roseburia intestinalis 139466 139038 NZ_GG692742.1 Roseburia intestinalis 31102 30953 NZ_GG698588.1 Blautia hansenii 886407 886556 NZ_GG704770.1 Subdoligranulum variabile 299826 299407 NZ_GG704865.1 Enterobacter cancerogenus 800444 800235 NZ_GG705267.1 Providencia rettgeri 240910 241179 NZ_GG729830.1 Bifidobacterium breve 1203629 1203057 NZ_GG739633.1 Edwardsiella tarda 295285 296013 NZ_GG739633.1 Edwardsiella tarda 756703 756912 NZ_KB946519.1 Enterococcus faecalis 1294830 1294402 NZ_KE136402.1 Enterococcus faecalis 1806226 1806654 NZ_KE992790.1 Clostridium symbiosum 1050 787 NZ_KE992799.1 Clostridium symbiosum 48485 48258 NZ_KE992855.1 Clostridium symbiosum 65420 64728 NZ_KE993024.1 Clostridium symbiosum 34019 34249 NZ_MTWC01000003.1 Clostridioides difficile 1879743 1879994 NZ_MTWD01000001.1 Clostridioides difficile 1922488 1922739 NZ_MTWE01000004.1 Clostridioides difficile 1625560 1625811 NZ_MTWE01000004.1 Clostridioides difficile 3637126 3636857 NZ_PUEL01000004.1 Ruminococcus gnavus 2325881 2326312 NZ_PUEM01000006.1 Clostridium bolteae 5802124 5802972 NZ_PUEM01000006.1 Clostridium bolteae 2707890 2708324 NZ_PUEM01000006.1 Clostridium bolteae 3193896 3193006 NZ_PUEM01000006.1 Clostridium bolteae 5630991 5631143 NZ_PUEM01000006.1 Clostridium bolteae 199448 199687 NZ_PUEM01000006.1 Clostridium bolteae 5725385 5725023 NZ_PUEM01000006.1 Clostridium bolteae 5665475 5665690 NZ_PUEM01000006.1 Clostridium bolteae 3020114 3019779 NZ_PUEM01000006.1 Clostridium bolteae 627804 627544 NZ_PUEM01000006.1 Clostridium bolteae 4780997 4781611 CVOZ01000058.1 Bacteroides thetaiotaomicron 302431 301628 CVOZ01000085.1 Bacteroides thetaiotaomicron 880 71 JGCP01000704.1 Bacteroides fragilis 2340 1621 JGCP01002431.1 Bacteroides fragilis 3248 2439 NC_000913.3 Escherichia coli 3081620 3080886 NC_000913.3 Escherichia coli 2579708 2580382 NC_008618.1 Bifidobacterium adolescentis 1034957 1035538 NC_009614.1 Bacteroides vulgatus 519272 518451 NC_009614.1 Bacteroides vulgatus 2993131 2992328 NC_009615.1 Parabacteroides distasonis 1971560 1972303 NC_010655.1 Akkermansia muciniphila 622533 623279 NC_012781.1 Eubacterium rectale 2329440 2328679 NC_012781.1 Eubacterium rectale 301575 302372 NZ_AAVM02000004.1 Bacteroides caccae 384982 384179 NZ_AAVN02000005.1 Collinsella aerofaciens 62689 63486 NZ_AAVN02000007.1 Collinsella aerofaciens 30286 31083 NZ_AAXA02000015.1 Dorea formicigenerans 777173 777955 NZ_ABJL02000008.1 Bacteroides intestinalis 710350 709553 NZ_ABJL02000008.1 Bacteroides intestinalis 872763 873572 NZ_ABXA01000019.1 Anaerococcus hydrogenalis 83461 84240 NZ_ABXA01000044.1 Anaerococcus hydrogenalis 26244 26918 NZ_ABXWO1000004.1 Providencia alcalifaciens 192888 193562 NZ_ACCL02000033.1 Marvinbryantia formatexigens 24594 25394 NZ_ACEP01000106.1 Eubacterium hallii 34351 35028 NZ_ACEP01000106.1 Eubacterium hallii 8467 9270 NZ_AHVA01000007.1 Salmonella enterica 437205 436471 NZ_ATFI01000008.1 Bacteroides cellulosilyticus 669051 668242 NZ_CVOY01000079.1 Bacteroides thetaiotaomicron 7940 7137 NZ_DS264265.1 Eubacterium ventriosum 121947 121150 NZ_DS264270.1 Eubacterium ventriosum 131247 130783 NZ_DS264282.1 Eubacterium ventriosum 44941 44159 NZ_DS264382.1 Ruminococcus torques 15883 16695 NZ_DS264541.1 Parabacteroides merdae 51592 50846 NZ_DS264563.1 Bacteroides ovatus 129699 128896 NZ_DS362241.1 Bacteroides uniformis 26081 26899 NZ_DS362248.1 Bacteroides uniformis 10119 9310 NZ_DS480669.1 Clostridium bolteae 172089 171322 NZ_DS480671.1 Clostridium bolteae 270573 271247 NZ_DS480676.1 Clostridium bolteae 208866 208069 NZ_DS480683.1 Clostridium bolteae 59202 58459 NZ_DS480723.1 Clostridium bolteae 62571 63365 NZ_DS499654.1 Erysipelatoclostridium ramosum 493613 494332 NZ_DS499659.1 Erysipelatoclostridium ramosum 506177 505422 NZ_DS499673.1 Bacteroides stercoris 364819 364016 NZ_DS499698.1 Clostridium scindens 88763 89650 NZ_DS499698.1 Clostridium scindens 61808 61131 NZ_DS499703.1 Clostridium scindens 55717 56514 NZ_DS499718.1 Clostridium scindens 274306 273629 NZ_DS544176.1 Anaerotruncus colihominis 236326 237081 NZ_DS544185.1 Anaerotruncus colihominis 120251 119532 NZ_DS544186.1 Anaerotruncus colihominis 57092 56349 NZ_DS544190.1 Anaerotruncus colihominis 45026 45862 NZ_DS544190.1 Anaerotruncus colihominis 194039 194773 NZ_DS562849.1 Clostridium spiroforme 87327 88040 NZ_DS607683.1 Providencia stuartii 286938 287612 NZ_DS981517.1 Clostridium sporogenes 154420 155220 NZ_DS990163.1 Ruminococcus lactaris 134129 134908 NZ_DS990241.1 Bifidobacterium longum 301034 300396 NZ_DS995509.1 Bacteroides eggerthii 1008704 1007901 NZ_DS995528.1 Bacteroides dorei 103973 104794 NZ_DS995535.1 Bacteroides dorei 358028 357237 NZ_DS995537.1 Bacteroides dorei 338316 337513 NZ_DS996445.1 Parabacteroides johnsonii 267454 266708 NZ_DS996843.1 Holdemanella biformis 245401 244601 NZ_DS996843.1 Holdemanella biformis 234112 233342 NZ_DS996850.1 Holdemanella biformis 117033 116224 NZ_DS996923.1 Bacteroides pectinophilus 107404 106727 NZ_EQ973495.1 Bacteroides cellulosilyticus 691462 692142 NZ_EQ973646.1 Bacteroides coprophilus 145177 144512 NZ_GG657587.1 Clostridium asparagiforme 820313 821107 NZ_GG657587.1 Clostridium asparagiforme 605673 604999 NZ_GG657589.1 Clostridium asparagiforme 122006 121344 NZ_GG657592.1 Clostridium asparagiforme 2356902 2356078 NZ_GG657592.1 Clostridium asparagiforme 2681628 2680816 NZ_GG657595.1 Clostridium asparagiforme 403564 402791 NZ_GG657595.1 Clostridium asparagiforme 346373 345594 NZ_GG661996.1 Proteus penneri 638905 638231 NZ_GG662008.1 Coprococcus comes 8233 7436 NZ_GG667643.1 Hungatella hathewayi 42915 43706 NZ_GG667648.1 Hungatella hathewayi 3211 2381 NZ_GG667661.1 Hungatella hathewayi 10879 11589 NZ_GG667677.1 Hungatella hathewayi 17130 17855 NZ_GG667681.1 Hungatella hathewayi 22622 21810 NZ_GG667686.1 Hungatella hathewayi 4731 4012 NZ_GG688324.1 Bacteroides finegoldii 86190 85387 NZ_GG692711.1 Collinsella intestinalis 24582 23785 NZ_GG692731.1 Roseburia intestinalis 6046 5264 NZ_GG692741.1 Roseburia intestinalis 5968 5225 NZ_GG698590.1 Blautia hansenii 337693 338493 NZ_GG703852.1 Prevotella copri 583896 584642 NZ_GG704769.1 Subdoligranulum variabile 60450 61163 NZ_GG704769.1 Subdoligranulum variabile 15116 14370 NZ_GG704770.1 Subdoligranulum variabile 5362 6141 NZ_GG704770.1 Subdoligranulum variabile 214747 215493 NZ_GG704772.1 Subdoligranulum variabile 45873 45049 NZ_GG704863.1 Enterobacter cancerogenus 2013656 2012844 NZ_GG704863.1 Enterobacter cancerogenus 2101556 2102290 NZ_GG704865.1 Enterobacter cancerogenus 539453 538719 NZ_GG705265.1 Providencia rettgeri 100618 99944 NZ_GG705267.1 Providencia rettgeri 66251 65577 NZ_GG729830.1 Bifidobacterium breve 1233732 1233157 NZ_GG739632.1 Edwardsiella tarda 145991 145257 NZ_JGDE01000063.1 Bacteroides fragilis 109546 108737 NZ_JH370371.1 Alistipes indistinctus 595517 596176 NZ_JH724294.1 Bacteroides xylanisolvens 1474036 1473233 NZ_KB946519.1 Enterococcus faecalis 1168242 1168913 NZ_KE136402.1 Enterococcus faecalis 1933289 1932618 NZ_KE992967.1 Clostridium symbiosum 16072 15284 NZ_MTWC01000003.1 Clostridioides difficile 2436150 2435359 NZ_MTWC01000003.1 Clostridioides difficile 3800319 3799558 NZ_MTWD01000001.1 Clostridioides difficile 2478316 2477525 NZ_MTWD01000001.1 Clostridioides difficile 3805291 3804530 NZ_MTWE01000004.1 Clostridioides difficile 2193127 2192336 NZ_MTWE01000004.1 Clostridioides difficile 3465381 3464620 NZ_PUEL01000004.1 Ruminococcus gnavus 2090336 2089539 NZ_PUEL01000004.1 Ruminococcus gnavus 2665987 2666715 NZ_PUEM01000006.1 Clostridium bolteae 2861084 2861881 NZ_PUEM01000006.1 Clostridium bolteae 6480829 6480086 NZ_PUEM01000006.1 Clostridium bolteae 5430429 5429662 NZ_PUEM01000006.1 Clostridium bolteae 238864 238070 NZ_PUEM01000006.1 Clostridium bolteae 3207435 3208109 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 2219764 2218961 NZ_PUEP01000005.1 Bacteroides ovatus 2020302 2021105 NZ_PUEQ01000003.1 Bacteroides caccae 1665493 1666296 NZ_UFTH01000001.1 Bacteroides fragilis 3881025 3880216 QEKH01000003.1 Victivallis vadensis 96465 97208 CVOZ01000033.1 Bacteroides thetaiotaomicron 56026 56922 JGCP01000335.1 Bacteroides fragilis 10772 11557 JGCP01000867.1 Bacteroides fragilis 965 1840 JGCP01001597.1 Bacteroides fragilis 61154 60237 JGCP01002379.1 Bacteroides fragilis 46606 45821 NC_000913.3 Escherichia coli 439100 438342 NC_009614.1 Bacteroides vulgatus 518419 517508 NC_009614.1 Bacteroides vulgatus 2260819 2259929 NC_009615.1 Parabacteroides distasonis 3159114 3158230 NC_010655.1 Akkermansia muciniphila 372524 373408 NC_010655.1 Akkermansia muciniphila 1056059 1055319 NC_012781.1 Eubacterium rectale 302528 303298 NC_012781.1 Eubacterium rectale 2328598 2327729 NC_012781.1 Eubacterium rectale 2064027 2063158 NZ_AAVM02000003.1 Bacteroides caccae 171018 170122 NZ_AAVN02000003.1 Collinsella aerofaciens 103150 102221 NZ_AAVN02000005.1 Collinsella aerofaciens 63590 64447 NZ_AAVN02000007.1 Collinsella aerofaciens 31218 32021 NZ_AAXA02000003.1 Dorea formicigenerans 25120 25917 NZ_AAXA02000014.1 Dorea formicigenerans 48489 49244 NZ_AAXA02000015.1 Dorea formicigenerans 778056 778868 NZ_ABJL02000008.1 Bacteroides intestinalis 709463 708594 NZ_ABJL02000008.1 Bacteroides intestinalis 2841895 2842785 NZ_ABXA01000019.1 Anaerococcus hydrogenalis 84625 85167 NZ_ABXW01000004.1 Providencia alcalifaciens 141254 140499 NZ_ACCL02000030.1 Marvinbryantia formatexigens 4571 5425 NZ_ACCL02000033.1 Marvinbryantia formatexigens 25451 26320 NZ_ACEP01000011.1 Eubacterium hallii 19574 20422 NZ_ACEP01000106.1 Eubacterium hallii 9431 10198 NZ_ACEP01000106.1 Eubacterium hallii 35117 36001 NZ_ATFI01000004.1 Bacteroides cellulosilyticus 209297 210172 NZ_CVOY01000004.1 Bacteroides thetaiotaomicron 16373 15477 NZ_DS264265.1 Eubacterium ventriosum 120994 120227 NZ_DS264270.1 Eubacterium ventriosum 130607 129840 NZ_DS264282.1 Eubacterium ventriosum 44042 43233 NZ_DS264284.1 Eubacterium ventriosum 144020 143178 NZ_DS264344.1 Ruminococcus torques 6063 6932 NZ_DS264382.1 Ruminococcus torques 16851 17627 NZ_DS264543.1 Parabacteroides merdae 27784 28650 NZ_DS264584.1 Bacteroides ovatus 284623 283748 NZ_DS362220.1 Bacteroides uniformis 227049 227918 NZ_DS362248.1 Bacteroides uniformis 9278 8370 NZ_DS480669.1 Clostridium bolteae 171259 170429 NZ_DS480676.1 Clostridium bolteae 208042 207137 NZ_DS480683.1 Clostridium bolteae 58433 57519 NZ_DS480686.1 Clostridium bolteae 79885 79166 NZ_DS480723.1 Clostridium bolteae 63515 64309 NZ_DS480723.1 Clostridium bolteae 15660 16472 NZ_DS499654.1 Erysipelatoclostridium ramosum 494370 495266 NZ_DS499659.1 Erysipelatoclostridium ramosum 270170 269349 NZ_DS499659.1 Erysipelatoclostridium ramosum 466874 467341 NZ_DS499676.1 Bacteroides stercoris 578064 578954 NZ_DS499697.1 Clostridium scindens 60279 61052 NZ_DS499698.1 Clostridium scindens 89655 90635 NZ_DS499698.1 Clostridium scindens 61039 60128 NZ_DS499703.1 Clostridium scindens 56487 57446 NZ_DS544176.1 Anaerotruncus colihominis 237039 237902 NZ_DS544183.1 Anaerotruncus colihominis 240611 240078 NZ_DS544185.1 Anaerotruncus colihominis 119250 118453 NZ_DS544186.1 Anaerotruncus colihominis 56292 55369 NZ_DS544190.1 Anaerotruncus colihominis 45937 46782 NZ_DS544190.1 Anaerotruncus colihominis 195009 195800 NZ_DS562849.1 Clostridium spiroforme 120673 120311 NZ_DS607683.1 Providencia stuartii 189914 189132 NZ_DS981517.1 Clostridium sporogenes 155283 156140 NZ_DS981517.1 Clostridium sporogenes 1854924 1855802 NZ_DS990163.1 Ruminococcus lactaris 134998 135867 NZ_DS990181.1 Ruminococcus lactaris 125472 124558 NZ_DS990181.1 Ruminococcus lactaris 82189 81734 NZ_DS995509.1 Bacteroides eggerthii 308482 307574 NZ_DS995528.1 Bacteroides dorei 104826 105737 NZ_DS995535.1 Bacteroides dorei 357120 356392 NZ_DS995536.1 Bacteroides dorei 378895 379785 NZ_DS996456.1 Parabacteroides johnsonii 290834 289962 NZ_DS996842.1 Holdemanella biformis 160953 161444 NZ_DS996843.1 Holdemanella biformis 233309 232410 NZ_DS996843.1 Holdemanella biformis 244454 243681 NZ_DS996843.1 Holdemanella biformis 154069 154917 NZ_DS996850.1 Holdemanella biformis 116083 115316 NZ_DS996926.1 Bacteroides pectinophilus 25856 26650 NZ_EQ973491.1 Bacteroides cellulosilyticus 377200 376325 NZ_EQ973643.1 Bacteroides coprophilus 652762 653538 NZ_GG657587.1 Clostridium asparagiforme 821211 822050 NZ_GG657589.1 Clostridium asparagiforme 120718 120140 NZ_GG657591.1 Clostridium asparagiforme 587188 587907 NZ_GG657592.1 Clostridium asparagiforme 2680669 2679878 NZ_GG657592.1 Clostridium asparagiforme 2356058 2355147 NZ_GG657595.1 Clostridium asparagiforme 345552 344704 NZ_GG657595.1 Clostridium asparagiforme 402646 401852 NZ_GG661996.1 Proteus penneri 791418 792179 NZ_GG662007.1 Coprococcus comes 99625 98906 NZ_GG662008.1 Coprococcus comes 7280 6615 NZ_GG667622.1 Hungatella hathewayi 66639 67460 NZ_GG667643.1 Hungatella hathewayi 43732 44676 NZ_GG667648.1 Hungatella hathewayi 2203 1409 NZ_GG667661.1 Hungatella hathewayi 11831 12583 NZ_GG667677.1 Hungatella hathewayi 17929 18831 NZ_GG667681.1 Hungatella hathewayi 21744 21016 NZ_GG667686.1 Hungatella hathewayi 3887 2979 NZ_GG688317.1 Bacteroides finegoldii 362276 363025 NZ_GG688320.1 Bacteroides finegoldii 281488 282357 NZ_GG692711.1 Collinsella intestinalis 23654 22830 NZ_GG692711.1 Collinsella intestinalis 69274 68498 NZ_GG692726.1 Roseburia intestinalis 50658 51503 NZ_GG692731.1 Roseburia intestinalis 5084 4749 NZ_GG692731.1 Roseburia intestinalis 4582 4208 NZ_GG692741.1 Roseburia intestinalis 5015 4245 NZ_GG693674.1 Lactobacillus reuteri 15204 14458 NZ_GG698589.1 Blautia hansenii 218497 219342 NZ_GG698590.1 Blautia hansenii 338622 339425 NZ_GG703865.1 Prevotella copri 41671 42546 NZ_GG704769.1 Subdoligranulum variabile 14262 13399 NZ_GG704769.1 Subdoligranulum variabile 61204 62076 NZ_GG704769.1 Subdoligranulum variabile 963668 963213 NZ_GG704770.1 Subdoligranulum variabile 6326 7123 NZ_GG704770.1 Subdoligranulum variabile 215601 216464 NZ_GG704772.1 Subdoligranulum variabile 44998 44135 NZ_GG704863.1 Enterobacter cancerogenus 2012671 2011880 NZ_GG704864.1 Enterobacter cancerogenus 137859 137101 NZ_GG705265.1 Providencia rettgeri 155499 156254 NZ_GG705267.1 Providencia rettgeri 65114 64578 NZ_GG729830.1 Bifidobacterium breve 720986 720603 NZ_GG739633.1 Edwardsiella tarda 373885 373130 NZ_JDUD01000004.1 Bifidobacterium breve 259935 260318 NZ_JGDE01000029.1 Bacteroides fragilis 56625 55840 NZ_JGDE01000151.1 Bacteroides fragilis 69580 68663 NZ_JH370371.1 Alistipes indistinctus 1294336 1295106 NZ_JH724294.1 Bacteroides xylanisolvens 373560 372685 NZ_KB946519.1 Enterococcus faecalis 955995 956768 NZ_KE136402.1 Enterococcus faecalis 2137928 2137155 NZ_KE992967.1 Clostridium symbiosum 15212 14295 NZ_MTWC01000003.1 Clostridioides difficile 2435248 2434466 NZ_MTWC01000003.1 Clostridioides difficile 3799403 3798573 NZ_MTWC01000003.1 Clostridioides difficile 1160536 1161309 NZ_MTWD01000001.1 Clostridioides difficile 2477414 2476632 NZ_MTWD01000001.1 Clostridioides difficile 3804375 3803584 NZ_MTWD01000001.1 Clostridioides difficile 1257043 1257816 NZ_MTWD01000001.1 Clostridioides difficile 73882 74589 NZ_MTWE01000004.1 Clostridioides difficile 2192225 2191443 NZ_MTWE01000004.1 Clostridioides difficile 3464465 3463635 NZ_MTWE01000004.1 Clostridioides difficile 960760 961533 NZ_PUEL01000004.1 Ruminococcus gnavus 2089383 2088613 NZ_PUEL01000004.1 Ruminococcus gnavus 2666757 2667680 NZ_PUEL01000004.1 Ruminococcus gnavus 794583 793762 NZ_PUEM01000006.1 Clostridium bolteae 5429599 5428769 NZ_PUEM01000006.1 Clostridium bolteae 2861908 2862813 NZ_PUEM01000006.1 Clostridium bolteae 237920 237126 NZ_PUEM01000006.1 Clostridium bolteae 6480060 6479146 NZ_PUEM01000006.1 Clostridium bolteae 3429828 3430547 NZ_PUEM01000006.1 Clostridium bolteae 285775 284963 NZ_PUEO01000014.1 Bacteroides thetaiotaomicron 882473 881577 NZ_PUEP01000005.1 Bacteroides ovatus 3161127 3162002 NZ_PUEQ01000003.1 Bacteroides caccae 2533958 2534854 NZ_UFTH01000001.1 Bacteroides fragilis 2923509 2922724 NZ_UFTH01000001.1 Bacteroides fragilis 1585432 1584515 QEKH01000019.1 Victivallis vadensis 59802 59029 CVOZ01000028.1 Bacteroides thetaiotaomicron 11708 11028 CVOZ01000041.1 Bacteroides thetaiotaomicron 276698 276060 JGCP01000929.1 Bacteroides fragilis 984 1961 JGCP01001512.1 Bacteroides fragilis 86 724 JGCP01002412.1 Bacteroides fragilis 4520 5224 NC_000913.3 Escherichia coli 1858800 1858150 NC_000913.3 Escherichia coli 1653876 1653256 NC_000913.3 Escherichia coli 3791303 3790323 NC_000913.3 Escherichia coli 2172858 2172232 NC_000913.3 Escherichia coli 1861305 1860268 NC_000913.3 Escherichia coli 4494313 4493675 NC_000913.3 Escherichia coli 2675722 2674703 NC_000913.3 Escherichia coli 4596053 4596487 NC_000913.3 Escherichia coli 4496182 4495505 NC_000913.3 Escherichia coli 379529 378861 NC_008618.1 Bifidobacterium adolescentis 412571 413026 NC_008618.1 Bifidobacterium adolescentis 417228 418223 NC_009614.1 Bacteroides vulgatus 341339 342010 NC_009614.1 Bacteroides vulgatus 4657957 4657250 NC_009615.1 Parabacteroides distasonis 1570183 1569347 NC_009615.1 Parabacteroides distasonis 2557870 2557166 NC_010655.1 Akkermansia muciniphila 292548 291571 NC_010655.1 Akkermansia muciniphila 2578712 2579362 NC_012781.1 Eubacterium rectale 1291708 1292388 NZ_AAVM02000004.1 Bacteroides caccae 12927 13637 NZ_AAYG02000009.1 Ruminococcus gnavus 126809 127438 NZ_AAYG02000009.1 Ruminococcus gnavus 97702 98343 NZ_ABJL02000008.1 Bacteroides intestinalis 1955633 1955031 NZ_ABJL02000008.1 Bacteroides intestinalis 2224108 2223404 NZ_ABXW01000004.1 Providencia alcalifaciens 273231 272242 NZ_ABXW01000070.1 Providencia alcalifaciens 85714 84734 NZ_ACCL02000009.1 Marvinbryantia formatexigens 148973 147954 NZ_ACCL02000012.1 Marvinbryantia formatexigens 119480 120445 NZ_ACCL02000023.1 Marvinbryantia formatexigens 25242 24913 NZ_ACCL02000041.1 Marvinbryantia formatexigens 6824 5856 NZ_AHVA01000007.1 Salmonella enterica 629177 629791 NZ_AHVA01000007.1 Salmonella enterica 443202 442726 NZ_ATFI01000005.1 Bacteroides cellulosilyticus 148491 147889 NZ_ATFI01000005.1 Bacteroides cellulosilyticus 281258 280554 NZ_CVOY01000006.1 Bacteroides thetaiotaomicron 74981 74301 NZ_CVOY01000028.1 Bacteroides thetaiotaomicron 60888 60250 NZ_DS264270.1 Eubacterium ventriosum 132077 133096 NZ_DS264356.1 Ruminococcus torques 135544 134918 NZ_DS264356.1 Ruminococcus torques 138887 137853 NZ_DS264581.1 Bacteroides ovatus 127382 127984 NZ_DS264584.1 Bacteroides ovatus 820339 821043 NZ_DS362249.1 Bacteroides uniformis 410760 410056 NZ_DS480663.1 Clostridium bolteae 23590 22595 NZ_DS480674.1 Clostridium bolteae 133468 132818 NZ_DS480677.1 Clostridium bolteae 49418 50098 NZ_DS480679.1 Clostridium bolteae 3487 2807 NZ_DS480681.1 Clostridium bolteae 101114 100101 NZ_DS480681.1 Clostridium bolteae 102205 101171 NZ_DS480683.1 Clostridium bolteae 55885 54905 NZ_DS480685.1 Clostridium bolteae 12651 11935 NZ_DS499659.1 Erysipelatoclostridium ramosum 699981 700592 NZ_DS499667.1 Bacteroides stercoris 9893 10597 NZ_DS499698.1 Clostridium scindens 90702 91751 NZ_DS499700.1 Clostridium scindens 26495 25524 NZ_DS499701.1 Clostridium scindens 129720 128749 NZ_DS499706.1 Clostridium scindens 53386 54207 NZ_DS499706.1 Clostridium scindens 60521 61132 NZ_DS499706.1 Clostridium scindens 79791 80414 NZ_DS499706.1 Clostridium scindens 26668 27222 NZ_DS499706.1 Clostridium scindens 49864 50862 NZ_DS499718.1 Clostridium scindens 277445 276753 NZ_DS544175.1 Anaerotruncus colihominis 165749 166231 NZ_DS544175.1 Anaerotruncus colihominis 34216 34839 NZ_DS544185.1 Anaerotruncus colihominis 127019 126309 NZ_DS544190.1 Anaerotruncus colihominis 38245 39264 NZ_DS607671.1 Providencia stuartii 138632 139612 NZ_DS981517.1 Clostridium sporogenes 1442433 1443440 NZ_DS981517.1 Clostridium sporogenes 128139 128786 NZ_DS981517.1 Clostridium sporogenes 1549649 1550068 NZ_DS990194.1 Ruminococcus lactaris 63868 63188 NZ_DS995508.1 Bacteroides eggerthii 161989 161351 NZ_DS995531.1 Bacteroides dorei 1763 1143 NZ_DS995533.1 Bacteroides dorei 81701 82408 NZ_DS995533.1 Bacteroides dorei 169186 169599 NZ_DS996842.1 Holdemanella biformis 209702 208998 NZ_EQ973491.1 Bacteroides cellulosilyticus 1310769 1311371 NZ_EQ973491.1 Bacteroides cellulosilyticus 1172397 1173101 NZ_EQ973637.1 Bacteroides coprophilus 197189 197566 NZ_GG657587.1 Clostridium asparagiforme 63925 64557 NZ_GG657587.1 Clostridium asparagiforme 528913 529482 NZ_GG657591.1 Clostridium asparagiforme 956107 956775 NZ_GG657591.1 Clostridium asparagiforme 483157 483576 NZ_GG657591.1 Clostridium asparagiforme 577856 578869 NZ_GG657591.1 Clostridium asparagiforme 710248 710910 NZ_GG657592.1 Clostridium asparagiforme 1127425 1126616 NZ_GG657592.1 Clostridium asparagiforme 1430381 1431352 NZ_GG657592.1 Clostridium asparagiforme 2752837 2753874

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We claim:
 1. A method of modifying a naturally occurring bacteria in situ in a subject comprising: administering to the subject a vector in a delivery vehicle, wherein the vector encodes a DNA base editor or a prime editor targeting a specific nucleotide sequence in the bacteria, genetically modifying a DNA sequence to generate at least one change in the targeted nucleotide sequence in the naturally occurring bacteria in situ without introducing a double strand break in the DNA sequence, wherein said genetic modification does not lead to the death of bacteria.
 2. The method of claim 1, wherein the vector encodes the DNA base editor.
 3. The method of claim 1, wherein the vector encodes the prime editor.
 4. The method of claim 1, wherein said vector is a phagemid.
 5. The method of claim 1, wherein said naturally occurring bacteria is involved in a microbiome associated disorder or disease.
 6. The method of claim 1, wherein the bacteria with the genetic modification does not have a reduced in vivo growth rate as compared to the same bacteria without the genetic modification.
 7. The method of claim 4, wherein the phagemid comprises a nucleic acid sequence encoding a dCas9 (dead-Cas9).
 8. The method of claim 4, wherein the phagemid comprises a nucleic acid sequence encoding an nCas9 (nickase Cas9).
 9. The method of claim 7, wherein the phagemid comprises a nucleic acid sequence encoding a fusion protein of the dCas9 and a deaminase domain.
 10. The method of claim 8, wherein the phagemid comprises a nucleic acid sequence encoding a fusion protein of the nCas9 and a deaminase domain.
 11. The method of claim 1, wherein the vector is a packaged phagemid.
 12. The method of claim 1, wherein the vector further comprises a conditional origin of replication which is inactive in the targeted naturally occurring bacteria.
 13. The method of claim 1, wherein said genetic modification is a point mutation.
 14. The method of claim 1, wherein said genetic modification is a point mutation leading to gene disruption.
 15. The method of claim 1, wherein the genetic modification is in a bacterial toxin gene.
 16. The method of claim 1, wherein the genetic modification is in a DNA sequence coding for an immunogenic component expressed or secreted by the bacteria.
 17. The method of claim 1, wherein the genetic modification is a point mutation that results in a change of amino acid in a mimic peptide, wherein said mimic peptide is a bacterial antigen that mimics a human protein.
 18. The method of claim 1, wherein the naturally occurring bacteria is Bacteroides faecis or Bacteroides thetaiotaomicron and the genetic modification is in the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase gene.
 19. The method of claim 18, wherein the genetic modification in the beta-galactosidase gene results in a change in the amino acid sequence of the beta-galactosidase protein and results in lower identity with human MYH6 cardiac peptide (SEQ ID NO: 2324) as compared to the Bacteroides faecis or Bacteroides thetaiotaomicron beta-galactosidase protein without the genetic modification, wherein the changed amino acid corresponds to Leu9, Leu11, Met12, Ala13, Leu15, Thr18, Ala20, Ser21, and Ala22 of SEQ ID NO:
 2322. 